SubgroupOSS 12 Weeks P1...1 SubgroupOSS 12 Weeks P1...2 SubgroupOSS 12 Weeks P1...3 SubgroupOSS 12 Weeks P1...4 SubgroupOSS 12 Weeks P1...5 SubgroupOSS 12 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.245756227194037 0.466334722553838 0.526995343276555 0.598196822274328 1 FALSE StreptococcusStreptococcus mutans (SP100) 2.2865788265903 1.15742919535432 1.97556691654933 0.0482038487297158 1 FALSE PrevotellaPrevotella oralis (SP104) 0.0340282451208388 0.528760931306006 0.0643546886809341 0.948687808390559 1 FALSE StomatobaculumStomatobaculum longum (SP105) -1.3091599601454 0.471286450140277 -2.77784341085073 0 0 TRUE GranulicatellaGranulicatella adiacens (SP107) 0.250373415739819 0.794988724716725 0.314939580846299 0.752807528476324 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 1.67369025972369 0.724286185452599 2.31081345100876 0.0208431612171155 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 0.987856515697053 0.723313070966369 1.36573850985058 0.172021052540064 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) 0.587502280178 0.818430921952416 0.717839788819902 0.472856076874692 1 FALSE PrevotellaPrevotella salivae (SP111) -0.211714186614449 0.353602397844953 -0.598735155374375 0 0 TRUE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) 0.549457275145631 0.553862335310789 0.992046651515514 0.321174768731751 1 FALSE CatonellaCatonella morbi (SP118) -0.0218383175419468 0.5078805027659 -0.0429989287303136 0.965702387814736 1 FALSE PrevotellaPrevotella oris (SP12) -0.162224858023625 0.789044468046927 -0.205596597648255 0.837106035435712 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 1.29877928009107 0.672284959332536 1.93188805143065 0.0533733248768273 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.108762431007671 0.597743306940221 0.181955079621742 0.855617978606695 1 FALSE CampylobacterCampylobacter showae (SP122) 0.260934759328686 0.473810918004212 0.550714956987053 0.581829089810404 1 FALSE SelenomonasSelenomonas sp._HMT_138 (SP123) -0.0994645771224584 0.321759848285039 -0.309126752926441 0 0 TRUE FretibacteriumFretibacterium fastidiosum (SP124) 0.879125191440851 0.570855706175903 1.54001296987992 0.123557191981157 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.517552705896756 0.407951805866586 -1.26866139199299 0 0 TRUE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) 0.68974280467101 0.664879425920224 1.03739531978505 0.299551658622064 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.598220249764449 0.737720220026829 0.810903962673943 0.417420824461122 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.772721148237007 0.632068194468303 1.22252813066638 0.221507972629343 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.00614338367990974 0.690050699028383 -0.00890280045880665 0.99289668680073 1 FALSE PeptococcusPeptococcus sp._Oral_Taxon_167 (SP133) 0.295125006292954 0.390752770455564 0.755272972086364 0.45008521228086 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.555431122008253 0.539753978085214 1.02904498078672 0.30345853838473 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 1.64414543034633 0.947444727290603 1.73534706879216 0.0826793494194139 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.318512254264352 0.685302786715352 0.464775950774952 0.64209191167188 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.727548146846073 0.560576021770586 1.29785812912244 0.194336090375409 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.595208496753475 0.854766235157795 -0.696340674527927 0.486215506282095 1 FALSE StreptococcusStreptococcus cristatus (SP15) 2.10164938294221 0.789774288647578 2.66107597215035 0.00778913799871336 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.0479127368594576 0.504879941343525 -0.0948992679961857 0.924394837951103 1 FALSE SelenomonasSelenomonas infelix (SP156) 0.417164073736351 0.425396128849953 0.980648495472074 0.326766110701011 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.926861142405436 0.63501250231435 1.45959510880088 0.144401384320318 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.465636870626724 0.447323219878057 -1.04094053233736 0 0 TRUE ScardoviaScardovia wiggsiae (SP166) -0.208418889136053 0.654069715058874 -0.318649349354592 0.749992427187122 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.747547475692214 0.973590418363042 0.767825423907841 0.442590907946346 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.448071480310988 0.55231471382284 -0.811261168853653 0.417215704634071 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.232932475986891 0.73525406005041 0.316805426373193 0.751391246496859 1 FALSE ActinomycesActinomyces naeslundii (SP172) 1.22760682658343 0.738642498830226 1.66197697604398 0.0965173910015501 1 FALSE FusobacteriumFusobacterium periodonticum (SP173) 1.06569780527806 0.637145392855034 1.67261321705975 0.0944034632701764 1 FALSE PrevotellaPrevotella histicola (SP174) 0.366918652772829 0.502630802340835 0.729996353315452 0.465392413658269 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.579125970600207 0.782047996516696 -0.740524843973363 0.458981592105129 1 FALSE KingellaKingella oralis (SP176) 2.25261915268292 0.723798820106935 3.11221722128548 0.00185687813216745 0.26924732916428 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 1.88212593916772 0.752368819365069 2.50160013376958 0.0123633474747515 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) -0.25979824894477 0.520222807080159 -0.499398037550358 0.617499001432819 1 FALSE GemellaGemella haemolysans (SP183) 0.67525491936237 0.70389573724056 0.959310993996826 0.337402098539296 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 1.14207471358186 0.649970761701575 1.75711705953048 0.0788978585070498 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 1.37621263218567 0.776385464981449 1.77258938279911 0.0762967723079547 1 FALSE RothiaRothia dentocariosa (SP193) 0.903908918816715 0.90697007832479 0.99662485060838 0.31894663898677 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.686652960843508 0.434301419218684 -1.58105161636084 0 0 TRUE EikenellaEikenella corrodens (SP200) 0.238680297775609 0.435827034218166 0.54764913379864 0.583932845192058 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 1.73734257042301 0.984428712366645 1.76482313914463 0.0775934944907729 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.286111545250153 0.713129047188697 0.40120584959772 0.688268574355711 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.16981099954183 0.724597462608148 -0.234352186289204 0.814711574900283 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.856480040408629 0.629058643958006 -1.36152654229453 0.173347351519592 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.760237585477543 0.650476114965124 -1.16874020119602 0.242508319685586 1 FALSE NeisseriaNeisseria sicca (SP215) 1.49249827749173 0.632506279926361 2.35965764271225 0.0182918072650649 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.884357094482739 0.607605529311379 -1.45547901034576 0.145536696928677 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.301202202355033 0.509218919139721 0.591498451911187 0.55418649211041 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.857399694273411 0.58471438252703 1.46635642955777 0.142551209711086 1 FALSE PrevotellaPrevotella baroniae (SP221) 0.178910745198677 0.421347851961949 0.424615301503505 0.67111713660861 1 FALSE TreponemaTreponema maltophilum (SP227) 0.230815972690666 0.439450084283685 0.525238203257835 0.599417610360808 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.0847694379801954 0.460511456416093 -0.184076719046056 0.853953269896054 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 2.27803661180489 0.836998303718942 2.72167410815905 0.00649521602440567 0.92881589149001 FALSE NeisseriaNeisseria flavescens|subflava (SP240) 2.58889297606705 0.761972042858302 3.39762199982511 0 0 TRUE CardiobacteriumCardiobacterium hominis (SP242) 0.630803948188217 0.650387496735724 0.969889414163407 0.332101617180382 1 FALSE LautropiaLautropia mirabilis (SP245) 2.03603523917781 0.851963935309197 2.38981388154522 0.0168569128275418 1 FALSE ActinomycesActinomyces oris (SP249) 1.2731483378739 0.749926586954759 1.6976972946696 0.0895649086382817 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_132 (SP250) 0.165199149720803 0.477917075297265 0.345664882590873 0.729594578810697 1 FALSE ArachniaArachnia propionica (SP260) -0.564538573788638 0.570285757808956 -0.989922273278578 0.322212111804813 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 2.52204096793585 0.796017576483124 3.16832321602551 0.0015332096241989 0.223848605133039 FALSE Bacteroidetes_[G-5]Bacteroidetes_[G-5] bacterium_HMT_511 (SP264) -0.457790898413188 0.384019761929121 -1.19210244835703 0 0 TRUE MogibacteriumMogibacterium neglectum (SP265) 0.0873030164788089 0.536315427622718 0.162782966855512 0.870689319857836 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 1.51061256829857 0.679250946408362 2.22393884953146 0.0261525587800447 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.629405096256784 0.678980644864974 -0.926985328693649 0.353934151755053 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.161882032531644 0.342827687824989 -0.4721964948592 0 0 TRUE SolobacteriumSolobacterium moorei (SP279) -0.352636066925654 0.380717703100623 -0.926240266879453 0 0 TRUE DialisterDialister invisus (SP28) -0.848240915282034 0.681563012928302 -1.24455244664409 0.213296309452782 1 FALSE ColibacterColibacter massiliensis (SP283) -0.231760194501033 0.382796437171852 -0.605439789913685 0 0 TRUE ActinomycesActinomyces dentalis (SP286) 0.789677232407169 0.836821470974124 0.943662728309211 0.345342026085565 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.197696828557522 0.358421642460316 -0.551576147021901 0 0 TRUE PrevotellaPrevotella sp._HMT_317 (SP29) 0.203016595117134 0.665889884819089 0.304880130702527 0.760457449178908 1 FALSE ActinomycesActinomyces israelii (SP293) -0.292327226110349 0.391309722917732 -0.747048205014338 0 0 TRUE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.369945629575108 0.567314827693708 0.652099348573419 0.514337084287035 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP301) 0.214145160462403 0.405342437916964 0.528306785647428 0.597286422669154 1 FALSE ParvimonasParvimonas micra (SP31) -0.244593595407437 0.799427815901066 -0.305960826659185 0.759634472152592 1 FALSE TreponemaTreponema denticola (SP311) -0.344235589752622 0.378082770379495 -0.910476796938143 0 0 TRUE RothiaRothia mucilaginosa (SP318) 0.730973846789817 0.880636143323996 0.830052062172611 0.406509348914274 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.783821862421993 0.560110557654736 1.39940562039032 0.161691382438266 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.462333518714155 0.475838065058577 0.971619449270499 0.331239903087184 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 1.39218419403993 0.622220854255597 2.23744380233847 0.0252573484130436 1 FALSE GemellaGemella morbillorum (SP332) -0.344874571609685 0.522676811623676 -0.659823745649524 0.509366943203756 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.683092375453007 0.594240223982021 1.14952227716189 0.250340686242617 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.172184771680827 0.493006061754509 -0.349254877451317 0.726897970608377 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.212067234379601 0.546520752292303 0.388031439776285 0.697992767339481 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 1.016466681753 1.17783786829922 0.862993718499443 0.388140920612444 1 FALSE TreponemaTreponema sp._HMT_257 (SP367) 0.93536797166887 0.536662577021798 1.74293496829923 0.0813449750144311 1 FALSE StreptococcusStreptococcus salivarius (SP374) 1.2601379337515 0.886906959705587 1.42082314267756 0.15536818098324 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.198275337574112 0.487984910426737 -0.406314485012913 0.684511543695533 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.0272101393694556 0.452918030281575 -0.0600774037468531 0.952093986647108 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.429752896092836 0.493046801894802 -0.8716269823499 0 0 TRUE NeisseriaNeisseria mucosa (SP44) 1.41281947108363 0.671411640106787 2.10425227489193 0.0353564467427441 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) -0.515086346595002 0.545484841949334 -0.944272520487093 0.345030404553 1 FALSE RothiaRothia aeria (SP465) 1.67866737708352 0.774835323591144 2.16648276862672 0.0302743152016993 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.152558778182919 0.784521680403615 0.194460882335886 0.845815022405138 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 1.04571997982058 1.0643688776432 0.982478914768807 0.325863965636855 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -1.71888674629348 0.757157035937147 -2.27018526502363 0.0231963446522612 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.68174455551015 0.895023851315072 -0.761705461266147 0.4462358151282 1 FALSE StreptococcusStreptococcus constellatus (SP53) -0.214899822559088 0.366548946779659 -0.586278652406741 0 0 TRUE PrevotellaPrevotella maculosa (SP55) -0.0171957925480258 0.466956626905233 -0.0368252457663818 0.970624344486742 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.0120995921515278 0.919649838119664 0.0131567381953406 0.989502744569685 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP563) 1.1413589164014 0.651227116837563 1.75262805692732 0.0796658720478913 1 FALSE SelenomonasSelenomonas flueggei (SP57) 0.175482331472441 0.395323459830478 0.443895567310097 0.657118089493065 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.548935594967913 0.930873305395731 -0.589699577575222 0.555392078479353 1 FALSE PrevotellaPrevotella denticola (SP60) -0.346912032790897 0.787419807970628 -0.440568079795926 0.659525715739973 1 FALSE GemellaGemella sanguinis (SP61) 0.388140463326736 0.551568293592108 0.703703363365863 0.481617525350429 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.733484982402699 0.650029457673778 -1.12838729651973 0.259156390394014 1 FALSE TreponemaTreponema socranskii (SP63) 0.0263217773278104 0.632984136489091 0.0415836287364273 0.966830624328424 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.189189506698247 0.961595023774651 0.196745513465328 0.844026691530288 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.374789889666127 0.395316420391353 -0.948075694136597 0 0 TRUE CampylobacterCampylobacter concisus (SP67) 0.698748652450284 0.651765351056889 1.07208622139426 0.283681307008592 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 1.23502768774048 0.71413695454012 1.72939893376025 0.0837377207225223 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) -0.079555639425369 0.558406419355401 -0.14246906315512 0.88670951410367 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.0716053844295624 0.470272293838791 0.152263668023166 0.878978979463938 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) 0.18073518383809 0.712535858034306 0.253650650420162 0.79976546256826 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.0481591882558326 0.510571296267465 0.0943241200747099 0.924851690281218 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.808758190280106 0.802251959767527 1.00810995901395 0.313401677133718 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.0813977261484541 0.586311672022146 0.138830130854669 0.889584383559433 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -1.12705321375957 0.840574177443892 -1.34081351057777 0.179981008547549 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.222042801297295 0.52798441340922 -0.420548023119763 0.674085155007854 1 FALSE StreptococcusStreptococcus infantis (SP87) 1.5512104443794 0.690477431141301 2.2465766068782 0.0246670985952806 1 FALSE VeillonellaVeillonella parvula (SP88) -0.109077282589582 0.841995310302655 -0.129546187793343 0.89692548025524 1 FALSE PrevotellaPrevotella oulorum (SP9) -0.0461364183782066 0.710074653433517 -0.0649740392156193 0.94819467027121 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.151875513213939 0.830104183898179 0.182959580447758 0.854829733354929 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.436353041028544 0.681119401267193 0.640641039172763 0.521755929602907 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.429431797773405 0.493089889377214 0.870899620991598 0.383808963764991 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.585668013665614 0.479146614764391 -1.22231483145008 0.221588592686036 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.631564984258689 0.633925744871988 -0.996275966653199 0.319116077701962 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 1.282035529299 0.724787770703149 1.7688426614252 0.0769201351231494 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.492179890690214 0.42167017765801 1.16721531843637 0.243123426211759 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 1.5493879116428 0.875582989647779 1.76955003690292 0.0768021283005281 1 FALSE ActinomycesActinomyces sp._str._ChDCB197_nov_96.023% (SPN246) -0.171516359509672 0.349731721106105 -0.490422655878091 0 0 TRUE PrevotellaPrevotella veroralis_nov_97.348% (SPN464) -0.0851789159183702 0.325948365979849 -0.261326408746704 0 0 TRUE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.354080054256339 0.42015448866149 -0.84273776387431 0 0 TRUE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.0338382134305749 0.85236992490516 -0.0396989762799761 0.968333117845312 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.284863590746346 0.571569609588746 0.498388273217168 0.618210400589682 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.527357674364584 0.584931398137629 -0.901571835677902 0.367284357847725 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.0755977440467183 0.673270066144395 0.112284427673493 0.910597888633347 1 FALSE