SubgroupOSS 24 Weeks P1...1 SubgroupOSS 24 Weeks P1...2 SubgroupOSS 24 Weeks P1...3 SubgroupOSS 24 Weeks P1...4 SubgroupOSS 24 Weeks P1...5 SubgroupOSS 24 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) 0.747955588658672 1.49388018259598 0.500679771625938 0.61659651078323 1 FALSE PhocaeicolaPhocaeicola abscessus (SP103) -0.529980543929627 0.536545460081485 -0.987764473580931 0.323268010320901 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.8647544548294 0.766789716724304 -2.4318980995149 0.0150199323060075 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -1.7415928762537 0.820396809802802 -2.12286646589024 0.0337650432264653 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -1.02571745537428 0.841178169816112 -1.21938192428188 0.222699267288818 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -1.94136633708643 0.731190012049613 -2.65507775693564 0.00792901292935929 0.959410564452474 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) -0.672349247997801 0.61306082509786 -1.09670887532322 0.272768675416461 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP115) 0.0721792194140293 0.803374137736986 0.0898450871437684 0.92841031868548 1 FALSE CatonellaCatonella morbi (SP118) 0.733000101954782 0.707075514600398 1.03666452425387 0.299892230714695 1 FALSE PrevotellaPrevotella oris (SP12) -0.467386923891344 0.864756288577388 -0.540483983828834 0.588863303383405 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.0406139286422882 0.94666412536739 -0.0429021524677788 0.965779532910941 1 FALSE CampylobacterCampylobacter showae (SP122) 0.358799264268832 0.650622503181778 0.551470726134086 0.581311028839772 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.922987260466144 0.643942816568538 -1.43333730374474 0.151761466228737 1 FALSE LeptotrichiaLeptotrichia sp._HMT_212 (SP125) 0.146292519047831 0.682251595276826 0.214426056400018 0.830214824103241 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) 0.666120780932731 0.893972938468841 0.745124099699968 0.456196701350764 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0990439953503905 1.00974760130557 0.098087873863062 0.921862516347154 1 FALSE PrevotellaPrevotella veroralis (SP129) -1.05372883498897 0.681495767648565 -1.54620011599597 0.122056245522095 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.576890523853344 0.820196093582111 -0.703356829381913 0.481833403092428 1 FALSE PrevotellaPrevotella saccharolytica (SP137) 0.116766435334789 0.597708933259169 0.195356684227703 0.845113724208604 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.281570923973372 0.679840545254374 -0.414172008331774 0.678748140086899 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.36309061854374 1.22021712430151 -0.297562303718352 0.766037249168002 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.222646195475859 0.838138018643414 -0.265643832547087 0.790513524546399 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.115335702243642 0.839678216686758 0.137357025526683 0.890748597675819 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.234804909121494 0.999209684943401 0.234990625751185 0.814216009092899 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.49710767426788 0.876215266221455 -0.567335098384649 0.570486535271155 1 FALSE AggregatibacterAggregatibacter aphrophilus (SP150) -0.0995647140357398 0.690351043344717 -0.14422331217659 0.885324132934253 1 FALSE CardiobacteriumCardiobacterium valvarum (SP151) 0.850753965217764 0.636411393566742 1.33679876541768 0 0 TRUE PorphyromonasPorphyromonas endodontalis (SP155) 0.509940900142944 0.754365135476045 0.675986834705906 0.499049003809868 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -1.12676239024241 0.670870292482646 -1.67955326516647 0.0930442671063941 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.483675408532075 0.807320214679923 0.599112223052457 0.549098051270147 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.104466825012275 1.22676343784879 0.0851564546099162 0.932137008965216 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.309279063621085 0.768052417097985 0.402679630629466 0.687183920599597 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 1.41502820736529 1.12766508678909 1.25483020086615 0.209540406614436 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.556018626311908 0.960022251134724 -0.579172644857665 0.562472686742738 1 FALSE FusobacteriumFusobacterium periodonticum (SP173) -0.870374831499041 0.772363916046928 -1.12689732574995 0.259785894176823 1 FALSE StreptococcusStreptococcus anginosus (SP175) 0.237823306575664 0.989254383976439 0.240406623845023 0.810015043677242 1 FALSE KingellaKingella oralis (SP176) 0.546748006866209 0.970374180384218 0.563440390231452 0.573135040230718 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.627701719395937 1.10496133921812 0.568075729998032 0.569983546791302 1 FALSE GemellaGemella haemolysans (SP183) -1.47476769459049 0.708950476778824 -2.08021257181633 0.0375060396352375 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.113989183007125 0.917225560060435 -0.124276064657002 0.901096698005277 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.514839693995278 1.02801515304441 -0.500809440863402 0.61650524071013 1 FALSE RothiaRothia dentocariosa (SP193) -0.212849475965194 1.15603357113377 -0.184120497258953 0.853918926876946 1 FALSE EikenellaEikenella corrodens (SP200) 0.343193645293419 0.618895385840604 0.554526101091031 0.579218847813289 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.709021421413059 1.24513089850956 -0.569435247540452 0.569060802311255 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.30940533131374 0.938622036338601 0.329637830069146 0.741673634556304 1 FALSE CampylobacterCampylobacter gracilis (SP205) 1.81140731235162 0.888720885367348 2.03821845775897 0.0415280903914932 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.736827140398034 0.867113116440564 0.849747427904972 0.395465523768509 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.093032293807528 0.802497145179801 0.115928504377027 0.907709204772546 1 FALSE NeisseriaNeisseria sicca (SP215) -1.63914466612737 0.613411278256634 -2.67217888589521 0 0 TRUE TannerellaTannerella sp._HMT_286 (SP218) 0.522618781215803 0.765622391541289 0.682606448021602 0.494855558535323 1 FALSE StreptococcusStreptococcus australis (SP219) -0.247453449661549 0.785362752872323 -0.315081723390284 0.752699604918768 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) -0.126214715095498 0.808223544991008 -0.156163125756132 0.875904441471533 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.219580138026663 0.655457130450265 0.335003050277023 0.737622785253836 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 1.56678969862877 0.842303743541167 1.86012434426774 0.0628679356709256 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) -0.811829109423676 1.11156689511748 -0.730346606209313 0.465178346690944 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.0569695835341024 0.861286643532461 0.0661447428238857 0.947262589201803 1 FALSE LautropiaLautropia mirabilis (SP245) -1.40561828161758 1.06026608144241 -1.32572219956838 0.184931731356502 1 FALSE TreponemaTreponema sp._ovinefootrot (SP248) -0.532367059441246 0.621913616125463 -0.856014477955806 0.391989771280313 1 FALSE ActinomycesActinomyces oris (SP249) -0.308946421117672 0.985831697405433 -0.313386576969248 0.753986981011245 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.613637411991522 0.760568749588499 0.806813864392308 0.419773730166808 1 FALSE ActinomycesActinomyces johnsonii (SP26) -0.0637731981383511 0.900637387648412 -0.0708089615343025 0.943549799457188 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -2.39866150659527 0.903739762667893 -2.65415068107026 0.00795083137931111 0.959410564452474 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 1.37722826808313 0.973412160250365 1.41484596589476 0.157113663595675 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.0989125924346079 0.81383299702565 -0.121539176705919 0.903263986162689 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) -0.0927588206076831 0.658333457901602 -0.140899447680126 0.887949378482373 1 FALSE DialisterDialister invisus (SP28) 0.226953111345393 0.912393708079254 0.248744713313695 0.803558259395722 1 FALSE ActinomycesActinomyces dentalis (SP286) 1.50914972742394 1.05993204859509 1.4238174319045 0.154499328208103 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.325294953236326 0.786821672701956 -0.413429071061628 0.679292279124662 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.326413379520468 0.805795602315271 0.405082105911962 0.685417159219588 1 FALSE ParvimonasParvimonas micra (SP31) -0.544778807974893 0.997937701421579 -0.545904626309685 0.585131498106224 1 FALSE RothiaRothia mucilaginosa (SP318) -0.881818096588417 1.11666635395512 -0.789688068835514 0.429709960929826 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.726088937820945 0.609666831160552 -1.19096021090531 0.233669205389336 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.256952668704497 0.771756195844629 0.332945391417664 0.739175504833508 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.714535857021313 0.458411747260408 -1.5587206507939 0.119062511882742 1 FALSE SelenomonasSelenomonas sp._HMT_136 (SP328) 0.0551639049975826 0.537054644015891 0.102715627938878 0.918188669950139 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) -0.628552535340912 0.849306852537901 -0.740077079871274 0.459253225249598 1 FALSE GemellaGemella morbillorum (SP332) 0.327302430421864 0.675343565934833 0.484645811304652 0.627927611435509 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) -0.927859341431484 0.658565957632774 -1.40890875192925 0.158862151329238 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.356099209629117 0.775683497908672 0.459077975216954 0.64617817225971 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.485511534883857 1.61002902744684 0.301554522686945 0.762991680524969 1 FALSE TreponemaTreponema sp._HMT_257 (SP367) -0.375334339319331 0.693707601779741 -0.541055537457557 0.588469303352365 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.840231483612538 1.05649517216146 -0.795300826499312 0.426438532902256 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.487363368741738 0.669969756945213 0.727440848918188 0.466955938427358 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 1.13229205199383 0.845374697079291 1.33939666742548 0 0 TRUE NeisseriaNeisseria mucosa (SP44) -1.52680066111353 0.661530978110506 -2.30798059597215 0 0 TRUE RothiaRothia aeria (SP465) -1.26591311705339 0.987970251284885 -1.2813271608199 0.200078776636059 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 1.13748562418269 1.16503126358334 0.976356308829058 0.328887924841233 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -1.01290774159892 1.27087921312856 -0.797013383439814 0.425443258625476 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP50) 0.0057740516000902 0.470239587442254 0.0122789568430354 0.990203056098209 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 2.35197281320005 0.901784515500932 2.60813173521121 0.00910379111036084 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.712284019231213 1.08152447693368 -0.658592601852775 0.510157414887876 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.261018042309283 0.570799388718502 -0.457285076803065 0.647466154607046 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.0188277265633199 1.04085841020053 -0.0180886529606775 0.985568130097693 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP563) -1.36993155532387 0.658706441068347 -2.07973001311782 0 0 TRUE SelenomonasSelenomonas flueggei (SP57) 0.249757464865389 0.607283531113196 0.411269945699935 0.680874604690748 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.57089051397726 1.13870686973767 0.501349846171367 0.616124930347932 1 FALSE PrevotellaPrevotella denticola (SP60) 0.193623986552822 0.960609950374003 0.201563586216692 0.840257914871526 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.409896875295777 0.895983176805655 0.457482780823112 0.647324076112844 1 FALSE TreponemaTreponema socranskii (SP63) -0.0369532628043343 0.837830131910733 -0.0441059128776613 0.964819979578368 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.503858579735446 1.20184085124997 -0.419239019219066 0.675041458238665 1 FALSE CampylobacterCampylobacter concisus (SP67) -1.11506646591041 0.776218102315834 -1.43653756925229 0.150849433904753 1 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.0434238194914642 1.03615359317128 -0.0419086704689796 0.966571504437375 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.431821533202574 0.913940734779108 0.472483079886949 0.63658201613697 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.152774784102513 0.663256316491995 0.230340488742797 0.817827200861639 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.18485972002343 0.691742509146188 0.267237761998465 0.789286103177986 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.871959507858653 1.03765608773207 0.840316476882459 0.400730965437226 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.611610063691226 0.933448963775793 0.655215322343139 0.512329130535229 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.182810409619273 1.13806538682445 0.160632606646064 0.872382771982736 1 FALSE StreptococcusStreptococcus infantis (SP87) -0.942159934203871 0.943749997423569 -0.99831516479572 0.318126556327694 1 FALSE VeillonellaVeillonella parvula (SP88) 0.951859780773226 0.802727666035793 1.18578170536206 0.235708518111879 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.183535597199881 0.892246005093447 0.205700665682061 0.837024738540745 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.15877502483713 1.00789528677879 0.15753127028163 0.87482616542729 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.717118781475113 0.771159149410863 -0.929923196817369 0.352410851610502 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0517571105860533 0.642589897955481 -0.0805445444298583 0.935804169958939 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.149424039475915 0.591167958066258 0.252760721275708 0.800453122137541 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.216468697378243 0.742780867841518 -0.291430092979225 0.770722402008453 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -1.06470919002388 0.858960493033091 -1.23953220044413 0.215148471492418 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -1.1097596164737 1.06579302194903 -1.04125246986912 0.297758389627038 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -1.0548364202873 0.893596775028998 -1.18043892923972 0.237825686441637 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 1.14111021835076 0.865491678235293 1.31845313715488 0.187352002821005 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 2.33384129005139 0.925726917420845 2.52109044917228 0.0116991775484374 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.274650935437567 0.801094454198122 0.342844634609893 0.7317153451484 1 FALSE