SubgroupOSS 24 Weeks P1...1 SubgroupOSS 24 Weeks P1...2 SubgroupOSS 24 Weeks P1...3 SubgroupOSS 24 Weeks P1...4 SubgroupOSS 24 Weeks P1...5 SubgroupOSS 24 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) 1.36462261580805 1.46975635069435 0.928468596283573 0.353164550338312 1 FALSE PhocaeicolaPhocaeicola abscessus (SP103) -0.379989748847052 0.571605983626722 -0.664775666685808 0.50619398857659 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.71524682765727 0.788028598133634 -2.17663017778753 0.0295081716721744 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -1.58378286683901 0.850435624559151 -1.86231952319732 0.062558065180337 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.861706213773407 0.878235583370225 -0.981178888774483 0.326504532935284 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -1.81424652125365 0.740445093156667 -2.45021074218907 0.0142772624937572 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) -0.528517461089733 0.639319426368371 -0.826687629518715 0.408414134683908 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP115) 0.273378688736318 0.847075547090781 0.322732358023104 0.746897944189616 1 FALSE CatonellaCatonella morbi (SP118) 0.579177499058041 0.721452507083103 0.802793660527576 0.422094006936969 1 FALSE PrevotellaPrevotella oris (SP12) -0.58147174814228 0.892216413984398 -0.65171603999705 0.514584373157696 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.289295808172317 0.975035075356609 0.296702975599631 0.766693285087733 1 FALSE CampylobacterCampylobacter showae (SP122) 0.197050813774577 0.65464381166814 0.301004623067404 0.763410969221988 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.772533435423562 0.675214357039079 -1.14413064143251 0.252569461848434 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) 0.583897981514672 0.93777235101108 0.622643630818428 0.533518732825803 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.409648158161267 1.05032130444155 0.390021754703982 0.696520460363635 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.901211486104223 0.708368399513131 -1.27223558634693 0.203289427192733 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.368790214675902 0.864013654774176 -0.426833780505808 0.669500400104089 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.554046782378859 0.617024981934834 -0.897932496414503 0.369221538620496 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.0819286088146908 1.2319959377327 0.0665007134402306 0.946979189725583 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.0228685118125459 0.877038382412321 0.0260746989768513 0.97919775749135 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.0957735095264988 0.848813831462781 -0.112832173530266 0.910163610424099 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.54762612759221 1.03286778510273 0.530199639770682 0.595973520784538 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.0218133533841865 0.779300578331637 0.0279909369897884 0.977669379550651 1 FALSE AggregatibacterAggregatibacter aphrophilus (SP150) 0.0806720248355459 0.717311517812344 0.112464421429589 0.910455178318929 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.75344132944537 0.802499171380651 0.938868669669926 0.347798176735282 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.979734135862659 0.69102642750935 -1.41779546607775 0.15625048826707 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.453002719185039 0.860969488164778 0.526154208031981 0.598781067376286 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.716914088491299 1.16081187930451 0.61759713289705 0.536840935011851 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.518106905347189 0.819389518492683 0.632308436530014 0.527185351859283 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 1.33478503843258 1.21262639707794 1.10073889340444 0.271010313646362 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.335826023127868 1.00380664849528 -0.33455249935959 0.73796268192243 1 FALSE FusobacteriumFusobacterium periodonticum (SP173) -0.70942698858045 0.806889585900118 -0.879211977669851 0.379286351276643 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.1658017460997 0.922486159785122 -0.179733586613723 0.857361724493945 1 FALSE KingellaKingella oralis (SP176) 1.09416651445695 0.896256821446183 1.22081806048787 0.222154914094896 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 1.06430419917179 1.1132458275656 0.956036998134695 0.339053542584482 1 FALSE GemellaGemella haemolysans (SP183) -1.33372829021888 0.729695422276165 -1.82778766249969 0.0675814255533118 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.145432335331045 0.955783237182166 0.152160374521536 0.879060446531827 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.237970731298444 1.07542627719328 -0.221280376298332 0.824874128718541 1 FALSE RothiaRothia dentocariosa (SP193) 0.530923339669957 1.00116370118358 0.530306221692112 0.595899633668726 1 FALSE EikenellaEikenella corrodens (SP200) 0.237667105505843 0.638979324112457 0.371948037342152 0.709931538208061 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.334542466084522 1.27954115534803 -0.261455026035117 0.793741627576595 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.14273382086718 0.970601554184173 0.147057070176601 0.883086974435702 1 FALSE CampylobacterCampylobacter gracilis (SP205) 1.76841215063006 0.941187508225706 1.87891587507766 0.0602559808433848 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.534860268367941 0.888799700848677 0.601778182257741 0.547321799926138 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.326570610441194 0.84443614001104 0.386732157670234 0.698954506646563 1 FALSE NeisseriaNeisseria sicca (SP215) -1.53193328884158 0.619005719217349 -2.47482897375892 0 0 TRUE TannerellaTannerella sp._HMT_286 (SP218) 0.319616525568038 0.772730794230936 0.413619501065876 0.679152789227927 1 FALSE StreptococcusStreptococcus australis (SP219) -0.0526985955724509 0.820242646193599 -0.0642475684689194 0.948773101443619 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) -0.521908360215023 0.691867275929224 -0.754347514867018 0.450640578242479 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 1.59181441450724 0.870603872389714 1.82840263521673 0.0674891461790976 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) -0.529600581956226 1.15694663787408 -0.457757138159269 0.647126932584349 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.295221694159955 0.898748653212304 0.328480819531439 0.742548144279466 1 FALSE LautropiaLautropia mirabilis (SP245) -1.1559974757081 1.09604387519584 -1.05470000049181 0.29156255157161 1 FALSE TreponemaTreponema sp._ovinefootrot (SP248) -0.372928122535533 0.66437975931445 -0.561317706187113 0.574580973202768 1 FALSE ActinomycesActinomyces oris (SP249) -0.00202942441784576 1.0206994033422 -0.00198826844730248 0.9984135923484 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.43027639986279 0.772940983850409 0.556674324240599 0.577749962570812 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.151697276929483 0.955414200760213 0.158776451939671 0.873845002066165 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -2.24221883154454 0.934639505234849 -2.39901996329712 0.0164390184282791 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 1.8428321028436 0.947354796989236 1.94523963851796 0.051746143171701 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.469590832994916 0.722402153749357 -0.650040743314068 0.515665904031654 1 FALSE DialisterDialister invisus (SP28) -0.116721379445834 0.875080262851686 -0.133383627080636 0.893889993399734 1 FALSE ActinomycesActinomyces dentalis (SP286) 1.50153854923363 1.12817932014298 1.33093961431888 0.183208881115914 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.691569580092955 0.681858696637761 -1.01424178279617 0.310467395734708 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.106853370590035 0.811425390533099 0.131686008148985 0.895232653010814 1 FALSE ParvimonasParvimonas micra (SP31) -0.81993067123894 0.99821697629426 -0.821395238420826 0.411421174898153 1 FALSE RothiaRothia mucilaginosa (SP318) -0.688853428069136 1.17422526993023 -0.586645037974756 0.557442127978787 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.586161571877743 0.629601595834415 -0.931003948776368 0.351851521550106 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.470902886109834 0.824226743466671 0.571326870721558 0.56777809034924 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) -0.416707499330466 0.890554568503847 -0.467919108012151 0.639842438370679 1 FALSE GemellaGemella morbillorum (SP332) 0.149296595017036 0.674880503082287 0.221219303765888 0.824921679352226 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) -0.776325919183862 0.688441846316691 -1.1276564946442 0.259465017677292 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.580100329634185 0.835193834774785 0.694569698051726 0.487325007651612 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.973054603405141 1.65854036831105 0.586693349162215 0.557409675350522 1 FALSE TreponemaTreponema sp._HMT_257 (SP367) -0.513739647120484 0.701977680908953 -0.731846127152177 0.464262491173933 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.599840950936603 1.09238784532775 -0.549109872928538 0.582930050186992 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.304482948597475 0.670465279398697 0.454136788217503 0.649730376335521 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 1.4007696034976 0.909624522024299 1.53994265719695 0 0 TRUE NeisseriaNeisseria mucosa (SP44) -1.41958928382773 0.66842116352014 -2.12379463922368 0 0 TRUE RothiaRothia aeria (SP465) -1.05707105765277 1.02995470074152 -1.02632771799743 0.304737136294303 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.872532917902564 1.20490437604458 0.724151173528711 0.468972930650113 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.680844974672957 1.31684539891299 -0.517027264730522 0.605137126266675 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 2.30172707566217 0.956285628137604 2.4069451719617 0.0160865847492245 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.737095414246115 1.14855232549283 -0.641760412552243 0.521028757080775 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.445765204188736 0.548916975780077 -0.812081287074881 0.416744989994919 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.20798794423778 1.08571823226066 0.191567147034745 0.848081278711554 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP563) -1.26272017803807 0.668138359145772 -1.88990822148347 0 0 TRUE StreptococcusStreptococcus oralis (SP58) 0.564907510829455 1.20384937520258 0.469250989754754 0.638890242575373 1 FALSE PrevotellaPrevotella denticola (SP60) -0.0594437082159826 0.961323963121573 -0.0618352506505292 0.950694031228682 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.13567403386653 0.890732364201585 0.152317395571612 0.878936605321815 1 FALSE TreponemaTreponema socranskii (SP63) 0.216744079983672 0.881884262093466 0.245773838246248 0.805857310035193 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.158736997783887 1.24700547397741 -0.127294547695597 0.898707275511863 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.951674579676301 0.813088559800649 -1.17044394267413 0.241822360681148 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.230710882429893 1.08462935713866 0.212709420883211 0.831553618119642 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.663384217875802 0.979882798831828 0.677003636217167 0.498403647276909 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.354285496368813 0.708159081460282 0.500290832447206 0.616870308302481 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.383105805326028 0.732399765295246 0.523082916570283 0.60091655323493 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.800990282938683 1.08881352902506 0.735654234252491 0.461941148060869 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.280216026442837 0.912651976530202 0.307034919825831 0.758816792898906 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.104053533822681 1.15525627356755 -0.0900696548492682 0.928231863104142 1 FALSE StreptococcusStreptococcus infantis (SP87) -0.763669701816168 0.990853523477616 -0.770719065655539 0.440873468580455 1 FALSE VeillonellaVeillonella parvula (SP88) 1.04037054053831 0.812708801817115 1.2801270740666 0.200500448247297 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.115752329690579 0.938303597220588 0.123363408211859 0.901819331714194 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.506494675697018 1.02758274285963 0.492899164779185 0.622083837475533 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.130646968091581 0.674749218049567 0.19362300036335 0.846471087312394 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.334366151831766 0.633868361048733 0.527500932967467 0.59784576871837 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.411643073911238 0.742535728348857 -0.554374770391978 0.579322388899891 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.902355094624088 0.893047975303889 -1.01042174617442 0.3122932735593 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.854488215012491 1.10627562428818 -0.772400834161287 0.439877059972685 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.851075438419762 0.91759330490693 -0.927508334976447 0.353662666241961 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 1.10373825537171 0.931750149704247 1.18458607784722 0.236181144257688 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 2.22606148518885 0.990936174296634 2.24642266871417 0.0246769476878853 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.205167142812097 0.840572124074298 0.244080355434154 0.807168586597194 1 FALSE