SubgroupOSS 24 Weeks P2...1 SubgroupOSS 24 Weeks P2...2 SubgroupOSS 24 Weeks P2...3 SubgroupOSS 24 Weeks P2...4 SubgroupOSS 24 Weeks P2...5 SubgroupOSS 24 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) 0.151971035471529 1.62449799975337 0.093549536838212 0.925466997498921 1 FALSE TannerellaTannerella forsythia (SP101) 1.32876120701996 0.848105696262383 1.56674010430048 0.11717545261657 1 FALSE PrevotellaPrevotella oralis (SP104) 0.442446898941334 0.785318337367124 0.563398150646388 0.573163796213035 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.787307566949863 0.741802507697949 -1.06134390053915 0.288533641656871 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.06952764925998 1.04752723973349 -1.02100223143799 0.307253381502933 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -1.23356220656928 0.59453193078488 -2.0748460136376 0 0 TRUE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.312394589500289 0.698668765455625 -0.447128317374494 0.654782414230319 1 FALSE PrevotellaPrevotella salivae (SP111) -0.403303824297472 0.803902510072588 -0.501682504090024 0.615890873483174 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) 1.27079754731107 0.656538564400553 1.9356022878433 0 0 TRUE VeillonellaVeillonella atypica (SP116) 0.324138780090872 0.709004147746993 0.457174730388941 0.647545459806334 1 FALSE CatonellaCatonella morbi (SP118) 1.02973498964572 0.713684706408267 1.44284300952451 0.14906470031302 1 FALSE PrevotellaPrevotella oris (SP12) 0.650418569339625 1.09391780301359 0.594577186282017 0.552126133484605 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.208014840702537 0.92135536677321 -0.22577047706473 0.821379940130763 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.436691504596458 0.810670102830281 0.538679671387711 0.590107902989959 1 FALSE CampylobacterCampylobacter showae (SP122) 1.16128485041139 0.927161874629087 1.25251574961057 0.210381993038145 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 1.42153595477748 0.720303760126695 1.97352288502208 0 0 TRUE PrevotellaPrevotella sp._HMT_300 (SP126) 0.646633227202823 0.74864855805963 0.863734018106955 0.387734021596627 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.486861897581026 1.17102716626724 0.415756279278256 0.677588354358338 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.733870646630133 0.889957590259299 0.824613054220159 0.409591307687163 1 FALSE PeptococcusPeptococcus sp._Oral_Taxon_167 (SP133) 0.215161210648269 0.619091493615139 0.347543477607568 0.728183061186123 1 FALSE BergeyellaBergeyella sp._HMT_900 (SP14) 0.799154941630568 0.728345781860437 1.09721915267946 0.272545602646882 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.381660613996732 1.45809371838252 -0.26175314328911 0.793511766025885 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.711452986846066 0.90063821850603 0.789943145013563 0.429560972814797 1 FALSE NeisseriaNeisseria subflava (SP143) -0.832232521969997 0.465834997920534 -1.78653928039981 0 0 TRUE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.480054254639346 0.827719551579256 0.579972109784553 0.561933425991805 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.996952148149893 1.19653602529333 -0.833198605871889 0.404732728734133 1 FALSE StreptococcusStreptococcus cristatus (SP15) -1.41030389676347 1.04704903830969 -1.34693203963035 0.178002121472248 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.0969504582806956 0.843914673080163 -0.114881825584145 0.908538790789815 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.672615305894925 0.924261854983793 0.727732408589684 0.466777407440086 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.188630647518093 0.84783622168564 -0.22248477087127 0.823936527290195 1 FALSE PrevotellaPrevotella sp._HMT_306 (SP159) -0.510553257409888 0.564381024555877 -0.904625129471093 0.365664017722236 1 FALSE TreponemaTreponema lecithinolyticum (SP162) 0.407532248807865 0.741781906860979 0.549396318565427 0.582733499974604 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.17391881972904 0.941145110063237 -0.184794903431368 0.853389905486567 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.236217252749594 1.26128714785514 0.187282692249175 0.851438992478583 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 1.56121358292215 0.974401415476113 1.60222836104904 0.109105120686026 1 FALSE ActinomycesActinomyces naeslundii (SP172) 1.6654003206323 0.904329032487195 1.84158670218948 0 0 TRUE StreptococcusStreptococcus anginosus (SP175) 0.0640305659451925 0.969587356085627 0.0660389861143546 0.94734678675342 1 FALSE KingellaKingella oralis (SP176) 0.584336039672221 1.12844910712505 0.517822235830319 0.604582302678813 1 FALSE HaemophilusHaemophilus sp._HMT_036 (SP177) -0.0292173466898126 0.765623019409834 -0.0381615311309921 0.969558892249923 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.747511762217901 1.29147281080211 0.578805651939073 0.56272031706032 1 FALSE GemellaGemella haemolysans (SP183) -1.77212265906331 0.942573621258678 -1.88008938410231 0.0600958970429272 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.773883881932213 0.85497555090946 -0.905153230532747 0.365384215193108 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 2.09103513431448 0.9949393624236 2.10167092919197 0.0355821118285203 1 FALSE LactobacillusLactobacillus salivarius (SP190) -0.720232303351064 0.946662066287499 -0.760812468355874 0.446769086091684 1 FALSE LeptotrichiaLeptotrichia sp._HMT_221 (SP191) -0.303032437995761 0.749949184362904 -0.404070628136215 0.686160783031727 1 FALSE RothiaRothia dentocariosa (SP193) -0.569420925855826 1.19525604833855 -0.476400790146466 0.63378887185903 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.0596309022721411 0.879443267348477 0.0678052860100099 0.945940635821746 1 FALSE EikenellaEikenella corrodens (SP200) 0.255783302546729 0.848006750511792 0.301628851883971 0.762935011163075 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.85013929627868 1.1166505433485 0.761329765469297 0.446460126215764 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.59719308755153 0.883145635628945 0.676211333056332 0.498906478154669 1 FALSE CampylobacterCampylobacter gracilis (SP205) 2.03930163664625 0.742825078874544 2.74533223856146 0.00604496651735774 0.858385245464799 FALSE SelenomonasSelenomonas sputigena (SP21) 1.20664713195551 1.02980171819034 1.17172763517616 0.241306424188565 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.0314002856484121 0.843493244162388 0.0372264814990824 0.970304424059486 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.47735700943696 1.02699290869302 0.464810424099673 0.642067222170147 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.209846029170052 0.62379641185127 -0.336401468785757 0.736568142030278 1 FALSE LeptotrichiaLeptotrichia hofstadii (SP22) -0.201487698323093 0.666724801712193 -0.302205194415536 0.762495644693642 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.105744366043326 0.921438070372584 -0.114760144434414 0.908635240411231 1 FALSE FilifactorFilifactor alocis (SP234) 1.11552284653762 0.857892463824806 1.30030614975238 0.193496061146619 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 1.30502860847552 1.22615754851035 1.0643237568133 0.287182059477645 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) 0.0486710886600699 0.754840125718761 0.064478671710417 0.948589089276128 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.233796316804986 0.887862342284369 0.263324961168479 0.792300122154458 1 FALSE LautropiaLautropia mirabilis (SP245) -0.111573836099209 0.912226032140257 -0.122309419122184 0.902653972626491 1 FALSE ActinomycesActinomyces oris (SP249) -0.56914193876001 1.08827670287406 -0.522975395188508 0.600991375733748 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.728703890915691 0.689807786280669 -1.05638687386343 0.290791500428023 1 FALSE ArachniaArachnia propionica (SP260) 0.543096710833802 1.00274670646262 0.541609069701837 0.588087842468662 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.152664058649612 1.01594504453065 0.150268028247669 0.880553156305238 1 FALSE MogibacteriumMogibacterium neglectum (SP265) -0.646468773885749 0.50535510606667 -1.27923665186132 0.200813732699686 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.158827809876652 1.02229160979156 0.155364485392809 0.876533980704662 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_338 (SP269) 0.400608316572035 0.609450922200689 0.657326622996095 0.510970921525018 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.408045365614158 0.909982194522717 -0.448410274475949 0.653857128029322 1 FALSE SolobacteriumSolobacterium moorei (SP279) 1.50154467236001 0.632341566276284 2.37457847536777 0 0 TRUE DialisterDialister invisus (SP28) 1.61779925679156 0.888522009825458 1.82077566892166 0.0686409643012063 1 FALSE ActinomycesActinomyces dentalis (SP286) 2.14417951719911 0.823133264777405 2.60489960611536 0 0 TRUE PrevotellaPrevotella sp._HMT_317 (SP29) -0.467436210562624 0.740969625488786 -0.630843957003334 0.528142558729974 1 FALSE ActinomycesActinomyces israelii (SP293) 0.525057923438273 1.10022778560452 0.477226561906705 0.633200798676292 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.474855072537399 0.78567541349422 0.604390902886376 0.545583782508396 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.552166674698675 0.911635046230541 -0.605688292680051 0.544721759623041 1 FALSE ParvimonasParvimonas micra (SP31) 1.38586235663527 1.10566378795633 1.25342113193094 0.210052484911245 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.246656757752668 0.947593568458351 -0.260298049673296 0.794633876903313 1 FALSE TreponemaTreponema denticola (SP311) 1.22982519194875 0.683261183785608 1.79993422886239 0 0 TRUE RothiaRothia mucilaginosa (SP318) 0.400398862990749 0.786963543094346 0.508789595787853 0.610899712906974 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.828247280965224 0.779733224293307 -1.06221878863234 0.288136372183665 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.77338915184219 1.04354811769469 0.741114989072752 0.458623722029146 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.992201627200962 0.831213849432458 1.19367793002778 0.232603976852396 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) -0.681903733546145 0.658738075813127 -1.03516672040617 0.300591057759023 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 1.0377958111813 0.876319825081201 1.18426604246359 0.236307766434492 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.488611342574901 0.972670753244015 0.502339914041111 0.615428437189053 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.0599029680907285 1.58029732712392 0.0379061377011564 0.969762519389974 1 FALSE NeisseriaNeisseria elongata (SP369) -0.103337194491261 0.604443350682506 -0.170962579660407 0.864253189450241 1 FALSE StreptococcusStreptococcus salivarius (SP374) -1.31546852674939 0.77703566829087 -1.69293197266327 0.0904684166326595 1 FALSE PorphyromonasPorphyromonas sp._Oral_Taxon_B94 (SP378) -0.41470151276426 0.521322053491976 -0.795480471210572 0.426334066388376 1 FALSE MycoplasmaMycoplasma salivarium (SP379) -0.241041554517997 0.512538727631994 -0.470289446480748 0.638148236407115 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 1.21601906997967 0.79810712895648 1.52362887870656 0.127601444931904 1 FALSE Clostridiales_[F-1][G-1]Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP403) 0.294512632310836 0.6368832910337 0.462427946308379 0.64377446232495 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.37008604368824 1.19200776171349 0.310472847220598 0.756201404771929 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.0428033768202292 0.894826900739525 0.047834253513003 0.961848337435994 1 FALSE GemellaGemella bergeri (SP450) -0.146108548714803 0.558836023235484 -0.261451557594445 0.7937443020028 1 FALSE PrevotellaPrevotella dentalis (SP461) 0.193813078579709 0.557771462087098 0.347477581327824 0.728232558027156 1 FALSE RothiaRothia aeria (SP465) -1.4908622818385 0.748310207035097 -1.99230515342761 0.0463375866161436 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) 0.0323504224860955 0.78181367509816 0.0413786858896191 0.966994004438003 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.721332399280762 1.00120129143438 0.720466908554761 0.471237567110447 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.0317643458834505 1.09210686941668 0.0290853823677683 0.976796494047416 1 FALSE AtopobiumAtopobium rimae (SP504) -0.390658546044479 0.679449774513555 -0.574963096167287 0.565316255687198 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 1.32195530380239 1.31582835124312 1.00465634636424 0.315062355140376 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.243687109532368 1.28687311989379 -0.189363742054447 0.849807739958921 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.987801369132285 0.93347012734028 1.05820351417866 0.289962669495045 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.434293324996687 0.753794109365923 0.576143166417162 0.564518416422432 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.333703221102909 1.31193335562595 -0.25435988777318 0.799217536957236 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.491366766402113 1.21488210235139 0.404456338150901 0.685877178722264 1 FALSE PrevotellaPrevotella denticola (SP60) 0.63675754488747 1.1198942320995 0.568587217110426 0.569636301751459 1 FALSE GemellaGemella sanguinis (SP61) -0.480626704249985 0.698429441528494 -0.68815355664009 0.491356087178838 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.569116632034626 0.992725690047417 -0.573286898626994 0.56645045468367 1 FALSE TreponemaTreponema socranskii (SP63) 1.40778709920698 0.913871870000892 1.54046441894048 0.123447189427019 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.389073816642503 1.42882454234007 -0.272303425027467 0.785388722904886 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.96944307782748 0.783795089583023 1.23685780979212 0.216139875581989 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.68853627216949 1.06234794436343 0.648126892721639 0.516902881510817 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) 0.161661087191197 0.770168268817364 0.209903593456839 0.8337429175375 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) 0.5352326633121 0.846577335510051 0.632231269207827 0.527235767534527 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -1.30000080056181 0.666872306479975 -1.94939988949871 0 0 TRUE SelenomonasSelenomonas noxia (SP8) 0.0568724130877624 0.91172095890802 0.0623791879873852 0.95026086825824 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.482824514347177 0.802265696325156 -0.601826198675569 0.547289834058425 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 2.43139671300745 1.08451074406439 2.24192957636858 0.0249659241590466 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.429509664987001 0.925156844451223 0.464256052974211 0.642464306007847 1 FALSE StreptococcusStreptococcus infantis (SP87) -0.299088819603002 0.768807529366336 -0.389029514122365 0.697254313632386 1 FALSE VeillonellaVeillonella parvula (SP88) -1.28433092214629 0.947611866987467 -1.3553343588122 0.175311052840415 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.416589896714009 0.862548404656702 0.48297567355633 0.629113009038361 1 FALSE SchaaliaSchaalia georgiae (SP91) -0.262384237945785 0.715258426253369 -0.36683837381713 0.713739581910877 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.0995767573867253 1.3289873798612 0.0749267892951137 0.9402729616875 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 1.26929855563294 0.859478189414414 1.47682462599516 0.139722653585223 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.0490933184342345 0.706331415897577 0.0695046508328512 0.944587930779196 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.0717578068405468 0.72588490865288 -0.0988556257130586 0.921252901811154 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 1.48586522797101 0.940121053942219 1.58050415075837 0.113991457087873 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.248509617201478 0.822829333907089 0.302018422242514 0.762638019408879 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -1.58745047706145 1.03436169353374 -1.53471506822547 0.124853832892836 1 FALSE PrevotellaPrevotella sp._HMT_305_nov_93.898% (SPN590) 0.348273682602469 0.669349884983655 0.520316340400915 0.602843108708733 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.683400345551421 0.913785603791118 0.747878214228947 0.454533619355528 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -1.92720522163198 1.0974841212392 -1.75602105245579 0.079084813937759 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.258056927647395 0.976477967618398 -0.264273169702731 0.791569433033663 1 FALSE PrevotellaPrevotella sp._HMT_292_sp._HMT_300 (SPP5) 0.24691651565425 0.679141971513176 0.363571279660573 0.716178176613621 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) -0.399409250624886 0.548150616223557 -0.728648730483213 0.466216561869021 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 1.28228673488917 0.897222953279141 1.42917290535503 0.152954543174539 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.0705136151651826 1.08568107773996 0.0649487373510918 0.948214815686754 1 FALSE