SubgroupOSS 12 Weeks P2...1 SubgroupOSS 12 Weeks P2...2 SubgroupOSS 12 Weeks P2...3 SubgroupOSS 12 Weeks P2...4 SubgroupOSS 12 Weeks P2...5 SubgroupOSS 12 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.174976684053207 0.257611188827521 -0.679227811686235 0 0 TRUE StreptococcusStreptococcus mutans (SP100) 1.96347611972328 1.17936721098199 1.66485561192464 0.0959415657786051 1 FALSE TannerellaTannerella forsythia (SP101) -0.0955673258854282 0.466290020331584 -0.204952543949942 0.837609202329164 1 FALSE PrevotellaPrevotella oralis (SP104) 0.855752919369478 0.519334080953113 1.6477888718548 0.0993960033784995 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.365997603370132 0.621236686155687 0.589143576878862 0.555764963190994 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 1.02135565632329 0.757810954718062 1.3477710370435 0.177732036070826 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 0.680581712472795 0.590922224207394 1.1517280694353 0.249432834034171 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.610062117313805 0.468257117493791 -1.30283575950534 0.192630839529024 1 FALSE PrevotellaPrevotella salivae (SP111) 0.693376794177344 0.642174546264299 1.07973260262479 0.2802612712937 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) -0.0706865813162074 0.250046605327531 -0.282693625148866 0 0 TRUE VeillonellaVeillonella atypica (SP116) 0.489359831309616 0.518037836209769 0.944641099750597 0.344842136812768 1 FALSE CatonellaCatonella morbi (SP118) -0.372412773607678 0.326068612871641 -1.14213008828998 0.253399950426224 1 FALSE PrevotellaPrevotella oris (SP12) -0.189651853470961 0.839637966113314 -0.225873365813673 0.821299913523194 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.658878801469762 0.657661036601071 1.00185166035529 0.31641524229895 1 FALSE CampylobacterCampylobacter showae (SP122) -0.0133391510031241 0.468633235752648 -0.0284639457585649 0.977292123487015 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.545584152602599 0.286053950243434 -1.90727711376928 0 0 TRUE PrevotellaPrevotella sp._HMT_300 (SP126) -0.499370794496216 0.459714873883182 -1.08626199165162 0.277363097661705 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) -0.0466984805350691 0.241076229393518 -0.193708357943667 0 0 TRUE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.429857943999632 0.816594916189111 0.526402914685895 0.598608290990854 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.139398840666646 0.588273476063438 0.236962648051828 0.812685767583054 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.488999837512323 0.540976251037919 -0.90392108077596 0.366037250107429 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.805976690714135 0.467581998848372 1.72371197501018 0.0847598521310144 1 FALSE BergeyellaBergeyella sp._HMT_900 (SP14) 0.52677672286379 0.43217114453202 1.21890767009494 0.222879238170788 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 1.80921212757491 0.938102844784203 1.92858612212299 0.0537822632612501 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.138521727332435 0.635554026657889 -0.217954291094437 0.827464725637961 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.319645423362262 0.450836590389949 0.709005058985531 0.478321337439165 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.0408316338474086 0.301341982274641 0.135499320536741 0.892217101436475 1 FALSE ActinomycesActinomyces viscosus (SP147) 1.79761026723124 0.808594165430623 2.22313039604226 0.0262070085593112 1 FALSE StreptococcusStreptococcus cristatus (SP15) 1.81311159984891 0.788354275134388 2.2998690525777 0.0214556398657691 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.199285836736432 0.611075349217062 -0.32612318103122 0.744331159050889 1 FALSE SelenomonasSelenomonas infelix (SP156) -0.0990389242560354 0.255811128850402 -0.38715643334639 0 0 TRUE BergeyellaBergeyella sp._HMT_322 (SP158) 0.303273250014079 0.596140800827296 0.50872755160058 0.610943207552242 1 FALSE TreponemaTreponema lecithinolyticum (SP162) 0.498638126073851 0.418398813989951 1.19177710213544 0.233348656446042 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.587929140253392 0.760722239798899 0.772856516471523 0.439607301506879 1 FALSE BulleidiaBulleidia extructa (SP168) -0.0492245905413993 0.245702803931104 -0.200341997542698 0 0 TRUE StreptococcusStreptococcus sanguinis (SP17) 2.28536971659518 0.868101362797664 2.63260699099703 0.00847323308600069 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.341560078853235 0.433621303752832 0.787692108061018 0.430876822915897 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.403844709094451 0.544684674597064 0.741428440947415 0.458433705206931 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.151153911088629 0.273440213852003 -0.552785959897033 0 0 TRUE StreptococcusStreptococcus anginosus (SP175) -0.155819429479523 0.641806611303234 -0.242782524728315 0.808173873856841 1 FALSE KingellaKingella oralis (SP176) 2.1485504786036 0.788614190579663 2.72446337419357 0.00644060734615335 0.966091101923002 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 1.60611997628416 0.830165008206617 1.93469968067411 0.0530271595932897 1 FALSE GemellaGemella haemolysans (SP183) 1.75686210201699 0.776755402342926 2.26179579403989 0.0237100228408821 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 1.66706378675293 0.726652171524276 2.29417024001453 0.0217807220146253 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.89895864979784 0.426847082665428 -2.10604379485115 0.0352005483198839 1 FALSE RothiaRothia dentocariosa (SP193) 2.1862511810743 0.884554367675262 2.47158485783083 0.0134515622426753 1 FALSE Ruminococcaceae_[G-2]Ruminococcaceae_[G-2] bacterium_HMT_085 (SP195) -0.0740342323638529 0.250630444455539 -0.295392016419562 0 0 TRUE TannerellaTannerella sp._HMT_808 (SP196) -0.0660911252648332 0.246428892588261 -0.26819552111229 0 0 TRUE EikenellaEikenella corrodens (SP200) 0.925531820300866 0.547569540705955 1.69025439053389 0.090979296736985 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.558245012590143 0.817061369497101 0.683235107460461 0.494458291804298 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.364251946559647 0.4975553471106 0.732083272092096 0.464117743217193 1 FALSE PrevotellaPrevotella multiformis (SP204) 0.258081669295182 0.357528786285896 0.721848643227312 0.47038753906959 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.205918264250875 0.744026593595618 -0.276761967950292 0.781962885997038 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.0253251309740845 0.648397857716559 0.0390580114858355 0.968844137385939 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.893408869197747 0.636673018739722 -1.40324600368055 0.160543493670948 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.129538666305285 0.755868607959275 0.17137722739276 0.863927159778601 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.171795274821942 0.478955825061639 0.358687097708504 0.719829181524802 1 FALSE LeptotrichiaLeptotrichia hofstadii (SP22) 0.736606241321337 0.442409180579374 1.66498859801391 0.0959150306258855 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.265880679533211 0.622593157703322 0.427053648507825 0.66934025255798 1 FALSE FilifactorFilifactor alocis (SP234) -0.136399504940519 0.435802328062606 -0.312984801037879 0.75429220947325 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 1.29757474670712 0.932469902508206 1.3915459825747 0.164059926047594 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 1.208450361745 0.568652494185821 2.1251122154581 0.0335772505342805 1 FALSE LautropiaLautropia mirabilis (SP245) 0.617420880826853 0.696212707639588 0.886827939294778 0.375171542965099 1 FALSE ActinomycesActinomyces oris (SP249) 0.990585658660467 0.834521818093798 1.18700989858258 0.235223716085035 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 1.05076235629827 0.551796986809811 1.9042553355958 0.0568769381212232 1 FALSE ArachniaArachnia propionica (SP260) 1.14484371745527 0.60887691934997 1.8802547461932 0.0600733676071096 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.896759425678279 0.715426118945094 1.25346196054536 0.2100376344049 1 FALSE Bacteroidetes_[G-5]Bacteroidetes_[G-5] bacterium_HMT_511 (SP264) -0.125874695484631 0.253887494694875 -0.49578926932147 0 0 TRUE MogibacteriumMogibacterium neglectum (SP265) 0.862386148375329 0.452490409291344 1.90586613697721 0.0566675754925908 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 1.21989636896306 0.762267243289359 1.60035260560184 0.109520382846636 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.0636020992547774 0.641264218065146 0.0991823611282738 0.92099347957803 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.354683409618909 0.268364316659532 -1.32164892126433 0 0 TRUE DialisterDialister invisus (SP28) -0.678088093469427 0.685899466124895 -0.988611490398732 0.322853262177364 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.165338884459525 0.278990851896645 -0.592631920851571 0 0 TRUE AnaeroglobusAnaeroglobus geminatus (SP287) 0.0119126257876212 0.249115996696776 0.0478195938662311 0 0 TRUE PrevotellaPrevotella sp._HMT_317 (SP29) -0.365561089270723 0.605851056484514 -0.603384421563795 0.54625298330156 1 FALSE ActinomycesActinomyces israelii (SP293) 1.5960982706404 0.718384733857958 2.22178756788001 0.0262976652930923 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.473360922916865 0.439926899593035 1.07599904291999 0.281927684437349 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.0938477117287522 0.32215638805085 -0.291311037774421 0.770813446429891 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP301) 0.187654708679898 0.224028042668156 0.837639370700855 0 0 TRUE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.742734428056665 0.643755267535142 1.15375277766736 0.248601539348517 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_348 (SP304) 0.496555825253209 0.449466405478944 1.10476738461485 0.269260396455968 1 FALSE ParvimonasParvimonas micra (SP31) -0.1551282415944 0.835862788785036 -0.185590558254048 0.852765858353018 1 FALSE TreponemaTreponema denticola (SP311) -0.343309766522574 0.267822862092293 -1.28185384862428 0 0 TRUE Ruminococcaceae_[G-1]Ruminococcaceae_[G-1] bacterium_HMT_075 (SP319) 0.0971352938253729 0.241587849831435 0.402070277512499 0 0 TRUE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 1.15331385239932 0.672308108671442 1.71545432447394 0.0862619627694612 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.171217232536843 0.546044503306052 0.313559117434934 0.753855914118316 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.251986400240691 0.461028530951202 -0.546574416383273 0.584671149442409 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 1.12383606723637 0.501149083950341 2.24251845055299 0.0249278842063449 1 FALSE GemellaGemella morbillorum (SP332) -0.136546554577725 0.521411025186939 -0.261878916980649 0.79341479434143 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.110492663985902 0.49253292455299 0.224335589516543 0.822496185399342 1 FALSE MycoplasmaMycoplasma faucium (SP343) 0.0961541025503041 0.229053510500514 0.419788818517533 0 0 TRUE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.237210702505516 0.552966568194531 0.42897837979613 0.66793895864325 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 1.5443692924714 1.03369929956614 1.49402180413549 0.135169920371846 1 FALSE SelenomonasSelenomonas sp._HMT_134 (SP371) -0.180782532600854 0.260895728094075 -0.692930213620312 0 0 TRUE StreptococcusStreptococcus salivarius (SP374) 1.53695039304423 0.636396972467062 2.4150812457295 0.0157317001797695 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.0965873609142073 0.45679368112382 0.21144635949556 0.832538984758319 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.417437709108729 0.290528441442688 -1.43682218180032 0 0 TRUE AlloprevotellaAlloprevotella rava (SP42) -0.0490736080997239 0.244057456049108 -0.201073996648763 0 0 TRUE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.386601740979538 0.753724553655227 0.512921781710165 0.608006036229854 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.475536429284068 0.487254746617849 0.975950326979632 0.329089080584422 1 FALSE GemellaGemella moribillum (SP45) 0.419198802084491 0.359228981223717 1.16694037506797 0.243234449328842 1 FALSE RothiaRothia aeria (SP465) 1.93571273672004 0.663267242641847 2.91845068212617 0.00351775516046323 0.53469878439041 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) 0.553636546936282 0.509907797570612 1.08575814995183 0.277586006266463 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.335806975606193 0.706260390863024 -0.475471908025098 0.634450651583759 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.163737178572283 0.837999111256966 0.195390635112588 0.845087147422501 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP50) 0.277351418625582 0.331038562729369 0.83782208434829 0.402130633580593 1 FALSE AtopobiumAtopobium rimae (SP504) 0.82478655762125 0.55339641358544 1.49040820896811 0.136116935387325 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.0921814865436197 0.852040726918571 -0.108189061427846 0.913845721740363 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.675842715587743 0.952921620530857 -0.709232219131771 0.478180382637568 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.666267665203546 0.432077675665162 1.54200900145526 0.123071406211935 1 FALSE TreponemaTreponema sp._HMT_238 (SP54) 0.432015241047082 0.326365415317554 1.32371636445219 0.185597261516202 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.239398397104029 0.504554541377041 -0.474474764315188 0.635161389452509 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.43599981558257 0.783231318568049 0.556668005027801 0.577754280871207 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP563) 0.606841540295896 0.541772455503812 1.12010408453042 0.262669410266563 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.154719269289104 0.844226360126413 -0.183267517571871 0.85458811994305 1 FALSE MogibacteriumMogibacterium vescum (SP59) 0.12033654290205 0.233382720657793 0.515618905130933 0 0 TRUE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.0407211169760185 0.248598745453507 0.163802584368368 0 0 TRUE PrevotellaPrevotella denticola (SP60) 0.895663604903134 0.838777110995328 1.06782075137971 0.285601375586748 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.626044709482212 0.761676130180218 0.821930325339309 0.411116552497774 1 FALSE TreponemaTreponema socranskii (SP63) -0.273848050730291 0.569856683373935 -0.480556004202542 0.63083209064473 1 FALSE StreptococcusStreptococcus gordonii (SP64) 1.19731782638435 0.913390427681945 1.31084998276473 0.189908451989408 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.399868007136452 0.274746906969613 -1.45540494539827 0 0 TRUE CampylobacterCampylobacter concisus (SP67) -0.026988943299729 0.423178903598971 -0.0637766747590643 0.949148051285391 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 1.72369686902677 0.743960865648324 2.31691873674653 0.0205081588999685 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.0292882264721803 0.342391421680546 0.0855401876846858 0.931831947382614 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) 0.652833809484749 0.439337259051667 1.48595138708227 0.137291979896953 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.624850029703583 0.282630185954543 -2.21083967939674 0 0 TRUE PrevotellaPrevotella melaninogenica (SP79) 0.791543280685083 0.646131061163439 1.22505065653369 0.22055613492068 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.318757536526056 0.696773319416469 0.457476668011639 0.647328468845949 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.453798084186971 0.646584509213916 0.701838781660072 0.482779710200903 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -1.16608125325184 0.824705623191052 -1.413936343419 0.157380593785876 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.657082605427237 0.554524705300733 1.18494739575378 0.2360382463079 1 FALSE StreptococcusStreptococcus infantis (SP87) 1.44715501557933 0.560727768994933 2.58085134284193 0.00985570114437194 1 FALSE VeillonellaVeillonella parvula (SP88) 0.781355660525272 0.428123677677448 1.82506995353327 0.0679904736657446 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.367025373036867 0.589566508336875 0.622534299094124 0.533590597637609 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.477466021029238 0.490139554766861 0.974143009650279 0.329985536864289 1 FALSE StreptococcusStreptococcus intermedius (SP94) 1.47588379172608 0.930709085857517 1.58576274171242 0.112793140486117 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.30226240649738 0.534584304821827 0.565415788999121 0.57179098775195 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.600746889630277 0.466534398481988 1.28767973290928 0.197857471389406 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.316797390928954 0.511920702417963 0.618840749031285 0.536021274757882 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.178031550930309 0.706669097371446 0.251930573436029 0.801094727402579 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.689847312757533 0.528080361278223 1.30633017877762 0.191440298505871 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 2.25142619065534 0.809880956952451 2.77994706669899 0.00543677598115071 0.820953173153757 FALSE PrevotellaPrevotella veroralis_nov_97.348% (SPN464) 0.0106218300315165 0.252741317169425 0.0420264883892971 0 0 TRUE FusobacteriumFusobacterium nucleatum_ss_animalis_nov_97.416% (SPN547) 0.373690221355023 0.391490013255246 0.954533215924927 0.339813804126223 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.0263248781095393 0.41888433668915 -0.0628452195601545 0.949889757009732 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 1.86664738666353 0.914247065929464 2.0417318865178 0.041178133977253 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.378960609844412 0.682233429899811 0.555470595892764 0.578572816986958 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) 0.906264461883521 0.435963836859996 2.07876063393431 0.0376393568133672 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.233756336371357 0.64074443587402 0.364819923956885 0.71524583148893 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.206050883345727 0.7884799038165 0.261326740666912 0.793840546768285 1 FALSE