SubgroupOSS 24 Weeks P2...1 SubgroupOSS 24 Weeks P2...2 SubgroupOSS 24 Weeks P2...3 SubgroupOSS 24 Weeks P2...4 SubgroupOSS 24 Weeks P2...5 SubgroupOSS 24 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) -0.608090836096154 1.6064790438187 -0.378523976665569 0.705041385657069 1 FALSE TannerellaTannerella forsythia (SP101) 1.18200277044648 0.794197499710177 1.48829827703792 0.136672249152949 1 FALSE PrevotellaPrevotella oralis (SP104) -0.0910703315547151 0.772376641705239 -0.117909225418381 0.906139583415602 1 FALSE StomatobaculumStomatobaculum longum (SP105) -1.22649572607207 0.726811075779937 -1.68750280085636 0.0915067118158222 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.09759061477583 1.02513852534647 -1.07067541374945 0.284315401414527 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -1.63293348859752 0.596914445937708 -2.7356240072768 0 0 TRUE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.0555993697528631 0.854651498910026 -0.0650550192959017 0.948130193926712 1 FALSE PrevotellaPrevotella salivae (SP111) -0.878057962577249 0.787133936413109 -1.11551277610831 0.264630746643324 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) 1.18987462382483 0.633757547113863 1.87749184091538 0 0 TRUE VeillonellaVeillonella atypica (SP116) -0.157200654302197 0.694394251452317 -0.226385304851551 0.820901756304093 1 FALSE CatonellaCatonella morbi (SP118) 0.498606383092357 0.690171597347242 0.722438282028428 0.470025057656754 1 FALSE PrevotellaPrevotella oris (SP12) 0.402358858670249 1.04726329450729 0.384200287339917 0.700830005363108 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.425183241070721 0.875836810132649 -0.485459432798132 0.627350482404571 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.329638623085509 0.785082138721435 0.419877878794122 0.674574668620301 1 FALSE CampylobacterCampylobacter showae (SP122) 1.03139933936018 0.87124137470914 1.18382731732008 0.236481426284463 1 FALSE SelenomonasSelenomonas sp._HMT_138 (SP123) 0.70302394726964 0.583295482082689 1.20526211648246 0 0 TRUE FretibacteriumFretibacterium fastidiosum (SP124) 1.24962867570943 0.664845110415035 1.87957865092718 0 0 TRUE PrevotellaPrevotella sp._HMT_300 (SP126) 0.113193937562322 0.733747746942424 0.154268190987992 0.877398276960009 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.123157368173788 1.14845640161324 -0.10723730391575 0.914600721803859 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.714565874339299 0.880652298432946 0.811405222709138 0.417133000871647 1 FALSE PeptococcusPeptococcus sp._Oral_Taxon_167 (SP133) 0.164944347384448 0.632221595329301 0.260896414489818 0.79417238994058 1 FALSE BergeyellaBergeyella sp._HMT_900 (SP14) 0.544466517514497 0.680993205983068 0.799518281138379 0.423989950711989 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -1.0531948366478 1.41384346245924 -0.744916155580529 0.456322407940473 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.475963511487053 0.850546111994335 0.559597539480873 0.575753983558041 1 FALSE NeisseriaNeisseria subflava (SP143) -1.23160380399825 0.467359463204693 -2.63523882784595 0 0 TRUE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.0145831554470674 0.789734681299341 -0.018465892143769 0.985267187050077 1 FALSE ActinomycesActinomyces viscosus (SP147) -1.65642747168676 1.17351044865664 -1.41151488986139 0.158092848319917 1 FALSE StreptococcusStreptococcus cristatus (SP15) -2.11324103222609 1.07373121427715 -1.96812852614028 0.0490532513894762 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.573272798054616 0.807808900649953 -0.709663879159251 0.477912596496391 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.858280105530621 0.696489415602544 1.23229454217636 0 0 TRUE PorphyromonasPorphyromonas endodontalis (SP155) 0.400729332988672 0.863682275562073 0.463977719964072 0.642663708364799 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.324785922473387 0.818731139978675 -0.396694234058139 0.691592952619975 1 FALSE PrevotellaPrevotella sp._HMT_306 (SP159) -0.933029445456801 0.559248131669735 -1.6683639919745 0.0952434917685728 1 FALSE TreponemaTreponema lecithinolyticum (SP162) -0.0773726906678591 0.704863245937872 -0.109769790258973 0.912591950109529 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.68699177894871 0.924244147492023 -0.743301194617129 0.457299348492544 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.10750602157542 1.19500868284623 -0.0899625443050052 0.928316979409785 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.919662320383503 0.967521854779466 0.950533898371866 0.341841037982951 1 FALSE ActinomycesActinomyces naeslundii (SP172) 1.62867737694098 0.852453911059591 1.9105752883655 0 0 TRUE FusobacteriumFusobacterium periodonticum (SP173) 0.152445814425907 0.728036493101307 0.209393094811105 0.834141382833415 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.0452302836817001 0.92831681384838 -0.0487228961136617 0.961140129082632 1 FALSE KingellaKingella oralis (SP176) 0.220575289596225 1.06856996927072 0.206421007457998 0.836462062593285 1 FALSE HaemophilusHaemophilus sp._HMT_036 (SP177) -0.506196587830486 0.751678376067045 -0.673421777115665 0.500678998045689 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.0171275964033585 1.28749705805871 0.0133030178951893 0.989386040469508 1 FALSE GemellaGemella haemolysans (SP183) -1.88639274941055 0.926182146020555 -2.03674056719366 0.0416760469354324 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.842921225029351 0.85936928811987 -0.980860308463543 0.326661633088045 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 1.99984432602487 0.934176191056935 2.14075711324031 0.0322936301028584 1 FALSE LactobacillusLactobacillus salivarius (SP190) -1.16189983526565 0.930086823403744 -1.2492380345886 0.211578024475417 1 FALSE LeptotrichiaLeptotrichia sp._HMT_221 (SP191) -0.754529807604333 0.732759966443782 -1.02970937572668 0.303146453030182 1 FALSE RothiaRothia dentocariosa (SP193) -1.04570290305995 1.14355806995862 -0.91442921048844 0.360491358832619 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.427067192586036 0.845918560557039 -0.504856155780305 0.613659870611934 1 FALSE EikenellaEikenella corrodens (SP200) 0.171631164085309 0.827777716156132 0.207339676745945 0.835744589768153 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.208631122805552 1.11041229706308 0.187886178275726 0.85096587791816 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.0883623410997754 0.838619107597211 0.105366477223431 0.916085015259867 1 FALSE CampylobacterCampylobacter gracilis (SP205) 1.72846371366772 0.734085192947933 2.35458190721239 0.0185435564869533 1 FALSE SelenomonasSelenomonas sputigena (SP21) 1.03863600389348 0.974366118184324 1.06596071487884 0.286441400995343 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.460330780788578 0.822768256491802 -0.559490205360353 0.575827213952917 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.447718771811487 1.00655984442565 0.444800946800094 0.656463610090124 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.204717264219681 0.663594785417606 -0.308497397385138 0.757703880325923 1 FALSE LeptotrichiaLeptotrichia hofstadii (SP22) -0.221537934234322 0.688689084771378 -0.321680623568856 0.747694658402732 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.0929457480414191 0.917166265799823 -0.101340129382501 0.919280461507087 1 FALSE FilifactorFilifactor alocis (SP234) 1.05875792968958 0.817267952085449 1.29548445768357 0.19515315954284 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.457196600373386 1.28657283004353 0.355360061783612 0.722319864902367 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) -0.441461153558474 0.740430298458226 -0.596222432385215 0.551026641668265 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.128759281634532 0.862189184346947 0.149339940667499 0.881285400530152 1 FALSE LautropiaLautropia mirabilis (SP245) -0.599634838961693 0.887155420990986 -0.675907315419296 0.499099492836294 1 FALSE ActinomycesActinomyces oris (SP249) -1.06622676171803 1.0540924805864 -1.0115115906385 0.311771636468542 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) 0.630859791271372 0.577501605360868 1.09239487027428 0 0 TRUE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -1.17604726309434 0.680955313711367 -1.72705497616959 0.0841577905511299 1 FALSE ArachniaArachnia propionica (SP260) 0.429965975241545 0.952207880226158 0.451546331605053 0.651595840388867 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.392640506285681 0.992297332138942 -0.395688362317095 0.692334941820101 1 FALSE MogibacteriumMogibacterium neglectum (SP265) -1.06124332659311 0.508619230529642 -2.0865182889133 0.0369317002988974 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.482901380107728 1.03377760288318 -0.46712308214158 0.640411820805383 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_338 (SP269) -0.0777161446726718 0.59473087328765 -0.130674475066445 0.896032825119232 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.328918117939405 0.935738802146098 -0.35150633615389 0.725208519825333 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.00449907297689123 0.613270041803248 -0.00733620211361089 0.99414661010344 1 FALSE SolobacteriumSolobacterium moorei (SP279) 1.38016234338858 0.602914820196966 2.28914980550269 0 0 TRUE DialisterDialister invisus (SP28) 1.43944395024135 0.851090488770253 1.69129366293496 0.0907807297599114 1 FALSE ActinomycesActinomyces dentalis (SP286) 2.15823596327021 0.810670439849845 2.66228526066642 0 0 TRUE PrevotellaPrevotella sp._HMT_317 (SP29) -0.344978459891718 0.823859274622799 -0.418734692341317 0.675410038417928 1 FALSE ActinomycesActinomyces israelii (SP293) 0.464384341251065 1.05505957908433 0.44014987443088 0.659828561381844 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.392512642275911 0.751599543438352 0.522236403285023 0.601505742792513 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.117801747087258 0.659653142774723 0.178581347451396 0.858266441614359 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -1.0100122921592 0.872312958904566 -1.15785542545138 0.24692304043763 1 FALSE ParvimonasParvimonas micra (SP31) 1.18394280080035 1.05592427988867 1.12123835330804 0.2621864182406 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.715831003635316 0.904212369265824 -0.791662476611038 0.428557507155643 1 FALSE TreponemaTreponema denticola (SP311) 0.698670025771741 0.654065653785414 1.06819555762969 0 0 TRUE SchaaliaSchaalia meyeri (SP312) 0.948357614700586 0.73556303859918 1.28929481898201 0 0 TRUE RothiaRothia mucilaginosa (SP318) -0.0930215871028057 0.76106550372208 -0.122225467647493 0.902720457398752 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.874857334620628 0.79686969212277 -1.09786749736975 0.272262352488188 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.239551817555332 0.995290530029231 0.240685317832067 0.809799019178467 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.885700340845467 0.790292116317413 1.12072526418793 0.262404824760381 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) -0.690050289860822 0.690771665122069 -0.998955696509179 0.31781615349341 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.910673531570642 0.835581622009899 1.08986783287564 0.27577136807868 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.0929409743042511 0.9385613856522 -0.0990249287100886 0.921118477130317 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.662158158447094 1.54226142511588 -0.429342358995551 0.667674094758102 1 FALSE TreponemaTreponema sp._HMT_257 (SP367) -0.0878191835497545 0.580089047184084 -0.151389142711888 0.879668753614023 1 FALSE NeisseriaNeisseria elongata (SP369) -0.550226988953021 0.584077639889538 -0.942044261542149 0.346169979440993 1 FALSE SelenomonasSelenomonas sp._HMT_134 (SP371) 0.501958790101149 0.495383653107936 1.01327281784928 0 0 TRUE StreptococcusStreptococcus salivarius (SP374) -1.75808225653442 0.763371291857621 -2.3030500036964 0.0212760298351615 1 FALSE PorphyromonasPorphyromonas sp._Oral_Taxon_B94 (SP378) -0.842572232097636 0.506898768543181 -1.66221005925735 0.0964706637869186 1 FALSE MycoplasmaMycoplasma salivarium (SP379) -0.682953296507235 0.507167572527654 -1.34660284588679 0.178108177110145 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 1.11766981101023 0.765053595148469 1.46090393940745 0.144041805377861 1 FALSE Clostridiales_[F-1][G-1]Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP403) 0.185612715430816 0.611455502308116 0.303558827633682 0.761464022950536 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.138627525738667 1.11384030203975 0.124459067861705 0.900951807450187 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) -0.431709344173929 0.841045037982068 -0.513301101222517 0.607740713785442 1 FALSE GemellaGemella bergeri (SP450) -0.583988007440826 0.542669238695364 -1.07613987637257 0.281864704015654 1 FALSE PrevotellaPrevotella dentalis (SP461) -0.260224658179963 0.535949821340557 -0.485539219938669 0.627293898974098 1 FALSE RothiaRothia aeria (SP465) -1.92838897724992 0.744163975768648 -2.59134954128636 0.00956003351093332 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) -0.452064961547472 0.758300388679723 -0.59615551870488 0.55107133800006 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.611059512435271 0.965955169543052 0.632596140796404 0.526997407906231 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.548852454515749 1.07523661388939 -0.510448070151197 0.609737586999574 1 FALSE AtopobiumAtopobium rimae (SP504) -0.531718512569598 0.667933399955106 -0.796065165487063 0.425994159895355 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 1.21160634323206 1.24398183434789 0.973974305555037 0.330069297217008 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.318152678125485 1.24392928526046 -0.255764280088372 0.798132857046264 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.413259188712135 0.898496272969716 0.459945356641523 0.645555442935274 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.432839562292838 0.767295108417883 0.564110936645129 0.572678635465851 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.654961973364507 1.22024551437698 -0.536746061057157 0.591443034593477 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.12712809116703 1.15296210051131 0.110262159624025 0.912201466476006 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.724165289967385 0.594165650904312 1.21879359546486 0 0 TRUE PrevotellaPrevotella denticola (SP60) 0.39696504594821 1.07181714108142 0.370366390621155 0.711109512488221 1 FALSE GemellaGemella sanguinis (SP61) -0.917789068296703 0.676479538440886 -1.35671371585307 0.174872192655875 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -1.09661014863729 0.974910207587439 -1.12483194872994 0.260660253284157 1 FALSE TreponemaTreponema socranskii (SP63) 1.30313986270653 0.869788815729142 1.49822559124782 0.13407464883407 1 FALSE StreptococcusStreptococcus gordonii (SP64) -1.05060075079433 1.38310945420131 -0.759593355105082 0.447497692308836 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.88076249267283 0.753446799025416 1.16897768205014 0.242412623346705 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.500911640172857 1.0064623337463 0.497695366609838 0.618698774357072 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) 0.0400268868305867 0.728745194929941 0.0549257643262193 0.956197605893082 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) 0.028476985236588 0.803862020181945 0.0354252154245856 0.971740678326448 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -1.69937208259006 0.665183867204775 -2.55474037536589 0 0 TRUE SelenomonasSelenomonas noxia (SP8) -0.104842892920627 0.882595335958919 -0.118789312212621 0.905442276345628 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.622496136910757 0.785548768722443 -0.792434743323622 0.428107227831372 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 2.24740876803238 1.03903327345214 2.16298055649889 0.030542675112433 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.318142418680307 0.882600803536343 0.3604601507336 0.718503051597543 1 FALSE StreptococcusStreptococcus infantis (SP87) -0.802392558302958 0.757413024988835 -1.05938574044827 0.289424141096236 1 FALSE VeillonellaVeillonella parvula (SP88) -1.66294535552293 0.866713017980815 -1.91868048710876 0.0550247824601428 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.347893300070587 0.841094236753936 0.413619883323923 0.679152509235119 1 FALSE SchaaliaSchaalia georgiae (SP91) -0.714379947178416 0.690434787611772 -1.03468127619912 0.300817783062875 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.108774975338718 0.774076514727831 0.14052225234732 0.888247372093562 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.592394261330695 1.3054519351082 -0.453784812293066 0.649983716020338 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 1.10170309991277 0.814181771874829 1.35314144576814 0.176010447201782 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0747701291436873 0.685565376368954 -0.109063455829263 0.913152159961908 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.547253365840948 0.7049490145081 -0.776302051039551 0.437570662342924 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 1.23657347901361 0.896257345624371 1.37970805489148 0.167676551837163 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.250835465699254 0.793640407188944 -0.316056822998349 0.751959378392088 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -2.07287734579543 1.00940465575276 -2.05356428066956 0.040017882267216 1 FALSE CapnocytophagaCapnocytophaga gingivalis_nov_97.665% (SPN399) -0.899661870236224 0.642304016643418 -1.40067919073232 0.161310028135461 1 FALSE PrevotellaPrevotella sp._HMT_305_nov_93.898% (SPN590) -0.134194653043201 0.655158228709155 -0.204827852513738 0.837706625183303 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.747334307435109 0.906696269908215 0.824238868337643 0.409803845995935 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -2.40798167714735 1.07455656673831 -2.24090732092075 0.0250320789411722 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.75724141855636 0.939835830865551 -0.805716694009177 0.42040622151714 1 FALSE PrevotellaPrevotella sp._HMT_292_sp._HMT_300 (SPP5) -0.230856713975114 0.667934763030053 -0.34562763723787 0.729622573089595 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) -0.837288709350909 0.547460724451679 -1.52940415988656 0.12616428183533 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 1.134178993491 0.862185378720698 1.31546999228157 0.188351995929887 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -0.0380998372133429 1.04604235451397 -0.0364228437299228 0.970945199599736 1 FALSE