Group12 Weeks.A.Plaque 2...1 Group12 Weeks.A.Plaque 2...2 Group12 Weeks.A.Plaque 2...3 Group12 Weeks.A.Plaque 2...4 Group12 Weeks.A.Plaque 2...5 Group12 Weeks.A.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.668524286016739 0.285568507682175 -2.34102944838994 0.0192306502057823 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.357141644717145 0.574161665847471 -0.622022795948941 0.533926878624044 1 FALSE TannerellaTannerella forsythia (SP101) -0.267762123403251 0.366690925199119 -0.730212025993966 0.465260592721284 1 FALSE PrevotellaPrevotella oralis (SP104) 0.128903743358219 0.32902755758826 0.391771875593251 0.695226777292394 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.177793424465597 0.418514511811044 -0.42482021399026 0.670967740824549 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.299997431754551 0.445300169444063 -0.673697097688248 0.5005039074333 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.214470415716133 0.378615617611419 -0.56645950600022 0.571081452936337 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) 0.00979193317025398 0.483226397847747 0.0202636553256745 0.98383304867853 1 FALSE PrevotellaPrevotella salivae (SP111) -0.0600980800629178 0.371504857805253 -0.161769298032765 0.871487531166409 1 FALSE CatonellaCatonella morbi (SP118) -0.340026884900313 0.355174200367181 -0.957352433112516 0.338389398631046 1 FALSE PrevotellaPrevotella oris (SP12) -0.193254767434721 0.484657648786932 -0.398744903579725 0.690081177694495 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -1.07136053490435 0.381436277486554 -2.80875364546864 0.00497336878325893 0.631617835473885 FALSE CampylobacterCampylobacter showae (SP122) -0.344375902834507 0.353873541179564 -0.973160925472419 0.330473327648874 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.896811521285455 0.314733550938418 -2.8494309507566 0.00437975114093392 0.560608146039541 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.359933823513603 0.39858348677515 -0.903032452311931 0.366508671669474 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.334667495352794 0.464850630179686 -0.719946308824901 0.471558053989324 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.27859404551776 0.385912204009144 -0.721910430982792 0.470349547707226 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.471343438435561 0.426114940904275 -1.10614154348896 0.268665259847191 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.244762211269825 0.320936147450989 0.762650805195456 0.445671676686151 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.252150759727477 0.518569124574524 0.4862432948247 0.626794678316663 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.0720024083561802 0.445773386003121 0.161522447541712 0.871681932899054 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.406526590661741 0.302822670724451 -1.34245758314328 0.179447674754568 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) -0.415815949132844 0.329678757344334 -1.26127613584318 0.207209376066718 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.345503748933797 0.513637439891581 0.672660756596571 0.501163139285307 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.0193303520777771 0.4654450555247 0.0415309000457332 0.966872659423524 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) 0.123478669685989 0.302096249316806 0.408739499299436 0.682730843359605 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.735443355627698 0.434478436049295 -1.69270392868072 0.0905118370970895 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.210448802770918 0.365406786350651 -0.575930197883536 0.56466236324474 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.0986996294173652 0.490947332422818 0.201039139840691 0.840667969627227 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 1.40237885785564 0.54494800530471 2.57341772830509 0.0100699585083196 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.11855945182569 0.336799085177628 -0.352018330938048 0.724824515158422 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.032268437282361 0.390457888469614 0.0826425543836136 0.934135763481286 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.238957288262658 0.421236478443902 0.567275866386015 0.570526770896485 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.402475073919144 0.470066646920553 -0.856208532461923 0.39188244384861 1 FALSE KingellaKingella oralis (SP176) 0.945714096028175 0.432993110235302 2.18413197271025 0.0289525518832978 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.17260437956087 0.436555780633263 -0.395377606294645 0.692564233197169 1 FALSE GemellaGemella haemolysans (SP183) -0.109600489126819 0.414381057259635 -0.264492035064594 0.791400801456234 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.0399671356947049 0.394353919205404 0.101348392264583 0.919273902450597 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 0.455439654582809 0.492312932563082 0.925101951337531 0.354912878145461 1 FALSE RothiaRothia dentocariosa (SP193) 0.935392015578093 0.569911014120573 1.64129485551616 0.100736223488161 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.237983375581257 0.336002635333277 0.708278300690123 0.478772449632809 1 FALSE EikenellaEikenella corrodens (SP200) 0.21060252530724 0.334689166599225 0.629248109364193 0.529186637160509 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.0767022557842818 0.478641272529471 -0.160249982996523 0.87268415737076 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.104832404511643 0.390517892148856 0.268444562001487 0.788357142271369 1 FALSE PrevotellaPrevotella multiformis (SP204) -0.436144329726163 0.282660542158221 -1.54299686258306 0.122831537153461 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.00808442267125864 0.429627236081266 0.0188172955350751 0.984986856423925 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.207586767680934 0.42189525749934 0.492033897018287 0.622695380915452 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -1.17720686324587 0.451019876272092 -2.61009974322215 0.00905158266541144 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.496614241792482 0.480834376359959 1.03281767321209 0.301689231460157 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.367968054224523 0.355869488359115 -1.0339971991451 0.301137472617397 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.0302610311988357 0.302240884826761 0.10012222938065 0.920247287511178 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.832642143593027 0.400240274937121 -2.08035571563566 0.037492917933964 1 FALSE FilifactorFilifactor alocis (SP234) -0.412997713386911 0.340876096103356 -1.2115772214831 0.225674258360492 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.343352197954703 0.499018674134895 0.688054807868548 0.491418267833182 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) -0.0647705473232149 0.302521125124503 -0.214102559933818 0.830467079546178 1 FALSE LautropiaLautropia mirabilis (SP245) 0.159100407171176 0.424173373596632 0.375083437751265 0.707598414119758 1 FALSE ActinomycesActinomyces oris (SP249) -0.112918462792 0.439743676449582 -0.256782459508424 0.797346711446945 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.0713138755613568 0.305391750664722 -0.233516050797487 0.815360707302382 1 FALSE ArachniaArachnia propionica (SP260) 0.300619379969376 0.355845904016364 0.844802136476333 0.398221321556607 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.620737427940223 0.446693516728192 1.3896271261934 0.164642134157403 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.537761684108755 0.416557881579353 -1.29096509246174 0.196715782209977 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.566504315778318 0.452979524111713 -1.25061793221057 0.211073904997898 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) 0.106763645102175 0.323163846621714 0.330370015762157 0.741120394783193 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.0682585618010029 0.364962788856765 0.187028825636775 0.851638032115775 1 FALSE DialisterDialister invisus (SP28) 0.019224143883587 0.471974396125266 0.0407313278885677 0.967510086268558 1 FALSE ActinomycesActinomyces dentalis (SP286) 0.603572363931303 0.425108987581455 1.41980617103668 0.155664117907987 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.484663481087556 0.360713213785433 1.34362552455828 0.179069511350127 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.454275846421619 0.455377914301466 -0.997579882894546 0.318483120054887 1 FALSE ActinomycesActinomyces israelii (SP293) 0.731170242619367 0.385188131484132 1.89821591802988 0.0576676447587649 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.172630914564504 0.361867468606259 -0.477055633736283 0.633322506130042 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.145707519885709 0.43153237357905 0.337651422713059 0.735625885890186 1 FALSE ParvimonasParvimonas micra (SP31) -0.137364739553098 0.468193005913143 -0.29339340361394 0.76922146687994 1 FALSE TreponemaTreponema denticola (SP311) -0.582207445639968 0.31163193304484 -1.86825348721948 0.0617267465515985 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.154713984591932 0.36760086564547 0.420874919106269 0.67384642061453 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) -0.256077095804864 0.377585079350252 -0.678197073479497 0.497646747860653 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.59709037964673 0.356820679552822 -1.673362598813 0.0942559360124318 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.238286888853582 0.336440504592583 0.708258624038562 0.478784666521005 1 FALSE GemellaGemella morbillorum (SP332) -0.504528133433054 0.366321368960328 -1.37728283464592 0.168424820167855 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) -0.462186809653169 0.38222148423862 -1.20921201112972 0.22658140438416 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.260870409254154 0.396783419636573 -0.657462979408499 0.510883267562237 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.079987573471769 0.32258585175795 0.247957475617335 0.804167309002973 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.318672650215445 0.574799675792528 -0.554406454346139 0.579300709889126 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.0631981064155379 0.359777272540288 -0.175658973590281 0.86056186837639 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.235621776363764 0.337117616857611 -0.698930475838303 0.484595480660928 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.65691776655648 0.350513944007104 -1.87415587250693 0.0609089442391336 1 FALSE AlloprevotellaAlloprevotella rava (SP42) 0.0951648513990103 0.325612554311931 0.29226407317159 0.770084725628751 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.104873148147768 0.535480195627987 0.195848789561259 0.84472852092339 1 FALSE GemellaGemella moribillum (SP45) -0.0131257117890719 0.327726097991201 -0.0400508591458721 0.968052579059133 1 FALSE RothiaRothia aeria (SP465) 0.681635875622329 0.372717157213917 1.82882881141721 0.0674252573958329 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.23956395881777 0.47855405098002 -0.500599583949133 0.616652955316895 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.557784856658082 0.524525460592167 -1.06340854460786 0.287596719522516 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.237570431338327 0.505217766880923 -0.470233722786556 0.638188043340954 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.55728772815511 0.526808305927612 -1.05785676095943 0.290120750581232 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.213724181859947 0.335509119669262 0.637014523094431 0.524115383718686 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.553547034694686 0.353959070910022 -1.56387300167651 0.117847396010523 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.113024998420452 0.530220869776615 0.213165880226612 0.831197580267276 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.413119469497366 0.501203735185573 -0.824254570537881 0.409794925797743 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) -0.169030088612908 0.312615910951584 -0.540695731379734 0.588717321180491 1 FALSE PrevotellaPrevotella denticola (SP60) 0.694561030450227 0.494623597582264 1.40422137933828 0.160252937407863 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.493962450005599 0.431978581543667 -1.14348829111026 0.252835913400378 1 FALSE TreponemaTreponema socranskii (SP63) 0.0104148949960795 0.430096945812026 0.0242152265843601 0.980680932633878 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.855635758434521 0.539685783392465 1.58543319977042 0.112867943025059 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.801936467364422 0.315550983767469 -2.54138477969498 0.0110414331878995 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.735290403103472 0.289069982047695 -2.54364150125472 0.010970361313965 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.243818380089465 0.357593391234551 0.681831337116464 0.495345606585462 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.0968050424538681 0.36884281596248 0.262456087700283 0.792969835924759 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.774899274429748 0.339563593177303 -2.28204463022376 0.0224867054564115 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.37681673026363 0.316802503387463 1.18943735050846 0.234267610402504 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.37605717001431 0.358873526975673 -1.04788216947471 0.294692898277376 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.500624089615489 0.412155015987481 -1.21464999865656 0.224499610644012 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.0217235297151052 0.416148816111034 -0.0522013493108414 0.958368257806747 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.128391421890142 0.519235877178802 0.247269935559421 0.804699324409824 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.186784805903586 0.425160935860034 0.43932729973357 0.660424395860455 1 FALSE VeillonellaVeillonella parvula (SP88) -0.429006695540361 0.326959632806385 -1.31210905718874 0.189483340452133 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.080720664368296 0.39903904931911 0.202287632015041 0.839691868333 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.0346651203879285 0.333897105607613 -0.103819769041862 0.917312377819622 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.260153756468158 0.510367959276056 0.509737634856975 0.61023528284851 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.0714168734135786 0.405990218327015 0.175907867208895 0.860366324593041 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.0133116454278241 0.340280412784678 0.0391196346533393 0.968795006760577 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.353974667045582 0.342838646378034 -1.03248181261126 0.301846463409167 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.160478779777343 0.454951729698711 0.352738036370625 0.724284841056089 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.00986430961681939 0.368615189775315 -0.02676045342253 0.97865079550985 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.422735385003818 0.422749588541221 0.999966402007743 0.317326767597114 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.0323782519872211 0.375840158490999 -0.0861489951399021 0.931347975874565 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.275447739060908 0.475141338000561 0.579717479897703 0.562105153629369 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.117610007566822 0.432422731465303 0.27197924394097 0.785637978899444 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.0499077426692612 0.440432750402348 -0.113315239667507 0.90978063555137 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.659638676940943 0.477791455126319 1.38059956883605 0.16740211600144 1 FALSE