Group24 Weeks.A.Plaque 2...1 Group24 Weeks.A.Plaque 2...2 Group24 Weeks.A.Plaque 2...3 Group24 Weeks.A.Plaque 2...4 Group24 Weeks.A.Plaque 2...5 Group24 Weeks.A.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.154923141571412 0.337993754575167 -0.458360959261329 0.646693135206087 1 FALSE StreptococcusStreptococcus mutans (SP100) 0.820545437875976 0.665005445235557 1.23389281058492 0.217242848874676 1 FALSE TannerellaTannerella forsythia (SP101) 0.0157717977205887 0.366044022078011 0.0430871610224724 0.965632053815299 1 FALSE PrevotellaPrevotella oralis (SP104) 0.179023563681217 0.325790830141325 0.549504611911754 0.582659200457321 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.67828834818059 0.377827990477277 -1.79523054214106 0.0726169762150755 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 0.547955507290959 0.480626675540281 1.14008550747832 0.254250679114176 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.0949709337265224 0.402589512938332 -0.235900167973501 0.813510137904692 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.479516619062166 0.492330257218981 -0.973973490418412 0.33006970195981 1 FALSE PrevotellaPrevotella salivae (SP111) -0.31775643317416 0.350252974023808 -0.90721980037366 0.364290574991823 1 FALSE VeillonellaVeillonella atypica (SP116) -0.0581598707272649 0.332748728016579 -0.174786154928193 0.861247667635175 1 FALSE CatonellaCatonella morbi (SP118) 0.115853388648571 0.38989131553051 0.297142778086589 0.766357506232119 1 FALSE PrevotellaPrevotella oris (SP12) -0.268120667344118 0.46328058037903 -0.578743592327477 0.56276219729611 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.00172809429303957 0.442177529723299 -0.00390814588457482 0.996881758675132 1 FALSE CampylobacterCampylobacter showae (SP122) 0.702349679196046 0.409005814811559 1.71721196560406 0.0859404500558607 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.0214160229505564 0.378732979735584 -0.0565464960709475 0.954906456244838 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.524337393113832 0.406564665605041 -1.28967772527286 0.197162576593705 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0239472062977153 0.509304951875527 0.0470193863411875 0.962497776549916 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.648870012743872 0.329732053352281 -1.96787059719253 0.0490829286664713 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.462300147559969 0.440555478344078 -1.04935739148591 0.294013660870836 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.230394132840748 0.267564702140568 -0.861078202758253 0.389194973379297 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.354875959946781 0.567430452883409 0.62540873184277 0.53170283269161 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.335329287123337 0.422044981606245 -0.794534473190796 0.426884348275511 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.0379161193775593 0.332855497772767 -0.113911651245862 0.90930782933137 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) -0.239556807199384 0.376410261196944 -0.636424752177634 0.524499612006381 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.176055884072994 0.542241187761964 -0.324681872285734 0.745421855809005 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.352276852008514 0.490415077092196 -0.718323861691322 0.472557620627979 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.254233230061602 0.320370469488266 0.793560125774682 0.427451553397755 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.361496428465693 0.427682302445488 -0.84524523553735 0.397973930703018 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.0726923965934047 0.39597624948613 0.183577668326673 0.854344783456269 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.347921895548604 0.431829707744824 -0.805692358141783 0.420420256879703 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 1.39400969333537 0.565109248359032 2.46679681386086 0.013632769070512 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.424110722295874 0.39492416590871 1.07390420467182 0.282865618639802 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.83070992186425 0.486507619814088 1.70749622006269 0.0877298597726224 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.228958286826429 0.417203760037009 0.548792481654812 0.58314787045447 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.350727321196383 0.491979930683814 -0.712889488619788 0.475914144088361 1 FALSE KingellaKingella oralis (SP176) 1.50080166525424 0.448476892135405 3.34644145901974 0.000818559616887831 0.109686988662969 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.0852147911863032 0.483787871020892 -0.176140817682102 0.860183314330592 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.143485390662833 0.314192218983236 0.456680280393857 0.647900866692189 1 FALSE GemellaGemella haemolysans (SP183) 0.318548070361949 0.426703094436002 0.746533302700773 0.455345321862972 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.0278091328695893 0.364925972843752 -0.0762048605444046 0.939256115781134 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 1.1358939463066 0.517101960180587 2.19665372359044 0.0280451862202759 1 FALSE RothiaRothia dentocariosa (SP193) 1.79926920902004 0.531047992794819 3.3881480269811 0.000703662770738841 0.0949944740497436 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.46333269335003 0.385869117997931 1.20075090682047 0.229847840557838 1 FALSE EikenellaEikenella corrodens (SP200) 0.841027239519621 0.380869474791284 2.20817706638344 0.0272319324258885 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.275642414676512 0.520979800783397 0.529084648314634 0.596746730436846 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.41007234527295 0.416220110611595 0.985229533167893 0.324511337011637 1 FALSE PrevotellaPrevotella multiformis (SP204) -0.281345624207586 0.309864506587522 -0.907963378271334 0.363897570544249 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.547803905320108 0.406484427792357 1.34766270948008 0.177766891115966 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.10273750229032 0.451085441177808 0.227756191869254 0.819835785433777 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.848912640533047 0.488398114055455 -1.73815708149245 0.0821831391796182 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.158165273641504 0.446323601179972 0.354373537996543 0.723058963126348 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.436310443087263 0.357431834765422 -1.22068154162487 0.222206619193973 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.542991054974678 0.365271831253685 1.48653963573108 0.137136441047623 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.185765744416096 0.43017082781883 -0.431841799589285 0.665856397221747 1 FALSE FilifactorFilifactor alocis (SP234) -0.227027397212101 0.357725123361093 -0.634642026478349 0.525661911899544 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.902399618501447 0.560820013573016 1.60907171046234 0.107600662235126 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.650746635431483 0.370578074276888 1.75603113244433 0.0790830928664445 1 FALSE LautropiaLautropia mirabilis (SP245) 0.422316714426436 0.450462709829385 0.937517590715535 0.348492379607709 1 FALSE ActinomycesActinomyces oris (SP249) -0.200327317772262 0.441253952844702 -0.453995519996545 0.649832051286553 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.0255725613368388 0.315288127560485 -0.0811085451732809 0.935355630015033 1 FALSE ArachniaArachnia propionica (SP260) 0.469252019852951 0.373481530882602 1.25642630505457 0.20896144938184 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.676886103903919 0.443081437923594 1.52767876505051 0.126592314925308 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.012208514903681 0.451146375619252 -0.0270610949426855 0.978411005126078 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.285623335801237 0.463319080664261 -0.616472206134352 0.537582910298127 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) 0.320424099438581 0.323624676309836 0.990110219938264 0.322120248582156 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.25726587277419 0.358874044472107 0.716869544445937 0.473454595557842 1 FALSE DialisterDialister invisus (SP28) -0.380032148017219 0.447648189702334 -0.848952719478043 0.395907601688003 1 FALSE ActinomycesActinomyces dentalis (SP286) 1.3913149853186 0.471576546693747 2.95034813557459 0.00317416046034263 0.42216334122557 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.194860198402935 0.338709599466687 0.575301670545361 0.565087291910288 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.469579702770371 0.450376878005485 -1.04263723495293 0.297116337236138 1 FALSE ActinomycesActinomyces israelii (SP293) 0.838955894199865 0.402836341559756 2.08262216599298 0.0372856771297314 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.16762298194003 0.280161040715495 -0.598309392026609 0.54963351094205 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.148591314566441 0.373401430677339 -0.397939864067743 0.690674514173728 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.207521818402595 0.471727326455124 0.439919009912048 0.65999576703826 1 FALSE ParvimonasParvimonas micra (SP31) -0.139472949670103 0.4747580709733 -0.293776890162541 0.768928395244891 1 FALSE TreponemaTreponema denticola (SP311) -0.152669418979589 0.353599517510664 -0.431757995752879 0.665917311150167 1 FALSE RothiaRothia mucilaginosa (SP318) 0.437649910494499 0.37328717402451 1.17242150534152 0.241027869581127 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.234649804209658 0.358816955060366 0.65395405902762 0.513141404095122 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.0715405979463817 0.421456774704542 0.169745991143539 0.865209903185344 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.40169089484584 0.364438041929181 -1.10221998976687 0.270366043535696 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.648781407836344 0.351835337642463 1.84399160182039 0.0651843641050299 1 FALSE GemellaGemella morbillorum (SP332) -0.0402874433826573 0.382675331191638 -0.105278391625621 0.916154908664016 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.862273365118928 0.447581853486381 1.92651547063931 0.054040042011365 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.315341305566067 0.414325906426511 -0.761094830602873 0.446600427883872 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.0875459643235083 0.324145325477952 0.270082452043452 0.787096821865128 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.186328188917557 0.63672330375179 -0.292636044290586 0.769800359857109 1 FALSE NeisseriaNeisseria elongata (SP369) 0.151762476167063 0.279971334462632 0.542064338330748 0.5877741846092 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.239451559241244 0.328432848294429 -0.729073113376844 0.465956940156209 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.0415609688804882 0.352807408255556 0.117800726141169 0.906225554177502 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.546820551760573 0.361004128897694 -1.51472104607296 0.12984306231028 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.108010660258387 0.31691615995652 -0.340817774244161 0.733240768818544 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.0288612243083291 0.526920066226588 0.0547734393852408 0.956318960927206 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.147116597972872 0.390889067039405 0.376364064329386 0.706646257848864 1 FALSE GemellaGemella moribillum (SP45) 0.132051971498905 0.321901658853153 0.410224575944621 0.681641214453516 1 FALSE RothiaRothia aeria (SP465) 0.659982052586053 0.41918615430539 1.57443666926374 0.115386531968829 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.224365994271607 0.521418842768513 -0.430298976309176 0.666978171673701 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.909061577800171 0.509168216077034 -1.7853855545112 0.074198800124995 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.749339117207694 0.496341105350478 1.50972609185485 0.131113330651355 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.879870411349427 0.541693205670018 -1.62429656148469 0.104312530759585 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.298536911791239 0.392994967265323 0.759645635842679 0.447466432733013 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.455113896046827 0.363073813031243 -1.25350240009643 0.210022926160911 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.0881120115771085 0.569565892044278 -0.154700295098181 0.877057597340265 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.391276521231449 0.509631217802435 -0.767764037137795 0.442627383731265 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.28234162237585 0.308647295213562 0.914771089053251 0.360311815330548 1 FALSE PrevotellaPrevotella denticola (SP60) 0.307549460040239 0.492544830591872 0.624409070887351 0.532358969444104 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.339783745930724 0.425031777383438 -0.799431393159555 0.424040313286444 1 FALSE TreponemaTreponema socranskii (SP63) -0.178048535235128 0.440707293705213 -0.404006327506402 0.686208066206896 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.997786322070493 0.589103393867458 1.69373718171955 0.0903152357222911 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.413610166056156 0.345376829429379 -1.19756199841058 0.231087577732194 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.534179915711143 0.405474581321153 1.31741899571271 0.187698217062869 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 1.11430431817317 0.415793006769207 2.67994963847885 0.00736332373801502 0.971958733417982 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.112469180122447 0.425185799432301 0.264517724422155 0.791381008937293 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.410486514662659 0.358494519194521 -1.14502870388355 0.252197267204164 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.706096344324872 0.369977963803918 1.90848216219464 0.0563289265059922 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) 0.0578827679166724 0.343163392753691 0.168674075204223 0.866053011559053 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.397068902788399 0.34305088813461 -1.15746356159438 0.247083018288561 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.393370371785756 0.401647790520469 -0.979391350008457 0.327386649446465 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.401127248270589 0.447256849862202 0.896861050633823 0.369793065986029 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.371713794720027 0.515507119842806 0.721064327556473 0.470869937545296 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.356865880436042 0.423184193082832 0.843287358718029 0.399067751015036 1 FALSE VeillonellaVeillonella parvula (SP88) -0.734820875519654 0.381173691789988 -1.92778486906833 0.0538818905278275 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.0772000757292937 0.371686411817084 0.207702173861782 0.835461520199561 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.0076056110540928 0.315137082133503 -0.0241342942017557 0.980745488465825 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.271890237261952 0.535660316504994 0.507579577736776 0.611748215696035 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.52782697640976 0.408310281689551 1.29271047063929 0.196111215005734 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.238269337869988 0.357732656162363 0.666054199317619 0.505376457913209 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.212911980349928 0.362149811839527 -0.587911337765022 0.556591805942085 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.605229117363888 0.435722180124785 1.38902526649104 0.164825067051573 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.444660608562069 0.397600012919974 1.11836165521344 0.263412564160598 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.549890097630843 0.459040391030893 1.19791222815039 0.230951188760164 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.237914109881999 0.393913186860456 -0.60397599729577 0.545859600396977 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.247681786137951 0.460111209738089 0.538308523886953 0.590364067602724 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.145270087616766 0.464146567260396 0.312983220955864 0.754293409934557 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.248281654781467 0.471871646216929 0.526163537843356 0.598774585552851 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.368900346298102 0.483672786066969 0.762706434856198 0.445638492088763 1 FALSE