Group12 Weeks.B.Plaque 1...1 Group12 Weeks.B.Plaque 1...2 Group12 Weeks.B.Plaque 1...3 Group12 Weeks.B.Plaque 1...4 Group12 Weeks.B.Plaque 1...5 Group12 Weeks.B.Plaque 1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.0252789687838703 0.290385768825066 0.0870530566499588 0.930629339030849 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.488028140180894 0.558111116966055 -0.874428273054048 0.381885065858947 1 FALSE TannerellaTannerella forsythia (SP101) -0.146507236911642 0.363772752524648 -0.402743844597637 0.687136675873288 1 FALSE PrevotellaPrevotella oralis (SP104) -0.226782279980922 0.289340793028865 -0.783789515494615 0.433163626861533 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.454932713587305 0.365315130161636 1.2453158274228 0.213015680001782 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.429691820896086 0.435178174597495 -0.987392856485777 0.323450084985403 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.418061135634861 0.378938568522826 -1.10324250514943 0.269921867266396 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 0.031888276243902 0.438970503643938 0.0726433233649965 0.942089950709401 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.464592810906957 0.46886645916857 -0.990885148259079 0.321741665197482 1 FALSE PrevotellaPrevotella salivae (SP111) 0.409004381459698 0.321455642072356 1.27235091853711 0.203248464563776 1 FALSE VeillonellaVeillonella atypica (SP116) 0.19372874588488 0.325150886663221 0.595811833309061 0.551300937632835 1 FALSE CatonellaCatonella morbi (SP118) 0.456071147088849 0.372943662401779 1.22289555519385 0.221369147586624 1 FALSE PrevotellaPrevotella oris (SP12) 0.0930428209372045 0.475777224697627 0.195559636122424 0.844954855889293 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.481397154689706 0.405007854683376 1.18861189757924 0.234592423886309 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.456327229168511 0.368580971675534 -1.23806507724501 0.215691931660693 1 FALSE CampylobacterCampylobacter showae (SP122) 0.586507496753567 0.326866138772591 1.79433543944304 0.0727596447764626 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.0436584608330345 0.370549210628022 -0.117820952199683 0.906209527723229 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) 0.0409490484872019 0.374495125456134 0.109344676882846 0.912929111981372 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.384886464392918 0.396221620757777 -0.971391878254446 0.331353171390279 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.135812107851896 0.337039898502999 0.402955580200211 0.686980902371739 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.489335103726684 0.387826897345447 -1.26173585967355 0.207043848805468 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.138207434260802 0.295266302810309 -0.468077233823703 0.639729359166585 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.953843416457536 0.528890227961452 1.80348088512435 0.0713127247647826 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.684352981248874 0.398791682304336 1.71606633642527 0.0861499017283709 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.0930081908599467 0.342124033906311 -0.271855180116976 0.785733374771195 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.412354106040636 0.496042279121934 -0.831288225613676 0.405810824558488 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.287747317221769 0.485854606780408 -0.592249848423938 0.553683293663286 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.256462989868182 0.359854085207788 -0.712686059184501 0.476040044930578 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.0136045690969955 0.290840485687174 0.0467767376500276 0.962691169399987 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.212279972259142 0.466768306482769 0.454786602498211 0.649262769654592 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.0907447494321385 0.375233235772177 0.241835585926707 0.808907563596106 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) 0.374173634855034 0.280711044156474 1.33294946046534 0.182548389713977 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.0709152517728663 0.486385175822453 0.145800602686856 0.884078800113587 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.414197867869595 0.557874604988101 0.742456932375384 0.45781053634596 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.493803097971743 0.329581984292874 -1.49827090528388 0.134062880038657 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.00762353561535928 0.428620454543263 0.0177862151340465 0.98580940175136 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.0787919117987955 0.374721424287046 0.210267966259754 0.833458535609396 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.335072356672834 0.478622747456672 -0.700076121440857 0.48387976727407 1 FALSE KingellaKingella oralis (SP176) 0.381730343499529 0.439771884716207 0.868018981581478 0.385383941462065 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.112015822357262 0.416290164520106 0.269081116740753 0.787867261364432 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.029238043568845 0.359148875866309 0.0814092582033548 0.935116486569935 1 FALSE GemellaGemella haemolysans (SP183) -0.528905140230758 0.36414351672211 -1.45246342703496 0.14637279128833 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.101960873176145 0.352128615855761 0.289555771911223 0.772156106915934 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.651260217500638 0.485431988785001 -1.34160960247118 0.179722611054012 1 FALSE RothiaRothia dentocariosa (SP193) -0.0247836579481757 0.557909933084644 -0.0444223278319291 0.964567764178045 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.409231472673763 0.34376734024497 -1.19043150632676 0.233876835910916 1 FALSE EikenellaEikenella corrodens (SP200) 0.322978076804794 0.345044359637881 0.936047982768809 0.349248483343078 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.327876821469119 0.55616815504103 -0.589528218214742 0.55550698848322 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.474689787536606 0.394884190742142 -1.20209873847945 0.229325275086342 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.459733928021913 0.442622031512501 1.03866029092799 0.298962755095 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.0492603572028783 0.441682501609609 -0.111528885621143 0.911196961067387 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.614415992181181 0.503325107247812 -1.22071397459351 0.222194334764119 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.387304805421285 0.445749394983303 0.868884646351102 0.384910228252884 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.368248680585388 0.326826655571281 1.1267400449382 0.259852406104181 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.0213369034731719 0.432754649754568 0.049304850878605 0.960676353779415 1 FALSE FilifactorFilifactor alocis (SP234) 0.0640373370933436 0.350242855959562 0.182836954426665 0.854925951889237 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) -0.749755078268593 0.509771477578227 -1.47076702256952 0.141354133655001 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.193680030879116 0.323826166427556 0.598098767050823 0.549774032901549 1 FALSE LautropiaLautropia mirabilis (SP245) 0.879568745006997 0.438614041073215 2.00533649778935 0.0449270854835927 1 FALSE ActinomycesActinomyces oris (SP249) -0.0519517796074774 0.469564851592963 -0.110638135352838 0.911903305474455 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) -0.155345979871277 0.291773488003432 -0.532419792265191 0.594435280058785 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.148952370243361 0.299540152073597 0.497270129604405 0.618998572914144 1 FALSE ArachniaArachnia propionica (SP260) -0.239057526618816 0.350514182275819 -0.682019555005345 0.495226585845334 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.497556789958426 0.442193592938098 -1.12520126456938 0.260503757405116 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.133768441353143 0.309293117179498 -0.432497310554475 0.665380006480876 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.375554107498755 0.429186757127473 -0.875036569190346 0.381554008361325 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) -0.486053253266517 0.280110129093344 -1.73522198158191 0.0827014944613927 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.0655412532887408 0.293769379791187 -0.22310444109365 0.823454221973295 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.439088055001968 0.276086924907592 -1.59039786164786 0.111745152038841 1 FALSE DialisterDialister invisus (SP28) 0.351451469215445 0.426080611632457 0.824847363668854 0.409458252849049 1 FALSE ActinomycesActinomyces dentalis (SP286) 0.0365697620246468 0.459243174983764 0.0796304964705022 0.936531139550465 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.368603381620793 0.367726876662051 1.00238357600265 0.316158371377832 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.0750207813972892 0.394495646852804 0.190168844690145 0.849176823937677 1 FALSE ActinomycesActinomyces israelii (SP293) 0.0943819954024882 0.483702284060108 0.195124146634709 0.845295759602028 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.333171698371703 0.339128371498182 -0.982435344173171 0.325885421118184 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.0304062541624981 0.332596165269579 0.0914209402800927 0.927158123483526 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.270243286530405 0.309990478292614 -0.871779314057869 0.38332878163757 1 FALSE ParvimonasParvimonas micra (SP31) -0.187065447418546 0.463522224564197 -0.403573847175127 0.686526120554322 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.0750767516587913 0.353573579573081 -0.212336995737753 0.831844134990729 1 FALSE TreponemaTreponema denticola (SP311) 0.370934533995395 0.343578260603719 1.07962166565372 0.280310689529521 1 FALSE RothiaRothia mucilaginosa (SP318) -0.197325060384353 0.413285265607673 -0.477454864243021 0.633038254087854 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.259848406726493 0.300015432087631 -0.866116802453663 0.386426111780747 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.155739434545395 0.369227254835385 0.421798316635183 0.673172234518716 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.280800627770189 0.35433153785891 0.79247991716165 0.428080897213182 1 FALSE GemellaGemella morbillorum (SP332) 0.268107065436577 0.347428637647493 0.771689597184568 0.440298293512458 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.550569394871382 0.399461331875376 1.37827957536363 0.168116986735154 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.119877354649939 0.397594046723108 0.301506915503249 0.763027977410075 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.567671508069476 0.588650046962836 -0.96436161179023 0.334864661321953 1 FALSE NeisseriaNeisseria elongata (SP369) 0.480244013870061 0.332774195779177 1.44315280439816 0.148977431116658 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.160620412941282 0.359061113502555 -0.447334470097494 0.654633582259934 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.0321095042750509 0.401765056675793 -0.0799210975208376 0.936300010105714 1 FALSE OlsenellaOlsenella uli (SP417) -0.317690618036153 0.310395159224463 -1.02350377766818 0.306069714689615 1 FALSE AlloprevotellaAlloprevotella rava (SP42) 0.174897918106825 0.341336231593633 0.512391893735569 0.608376763153831 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.717234500567701 0.388394636789391 -1.8466642755333 0.064795812340276 1 FALSE NeisseriaNeisseria mucosa (SP44) -0.260721507686292 0.33391360681766 -0.780805281255471 0.43491702740699 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.156878547593296 0.347142287127498 0.451914253637668 0.651330755645261 1 FALSE GemellaGemella moribillum (SP45) -0.233277491729495 0.31951828992849 -0.730091200042737 0.465334439991807 1 FALSE RothiaRothia aeria (SP465) 0.0587827688470223 0.400109902771569 0.146916555775883 0.883197884103314 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.112810146209043 0.47103185825134 0.239495788305784 0.810721161899688 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.465257780146837 0.535626384653911 -0.868623715105928 0.385052978799478 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.372480097675936 0.488133953737874 0.763069429658968 0.445421990439947 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.024394228681552 0.540102773272985 -0.0451659015444871 0.96397507312606 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.172535457123294 0.31960193983238 0.539844837030034 0.589304042884402 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.172116670635073 0.299984492673426 0.573751893310183 0.566135706669381 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.511164521952553 0.55548618534144 -0.920211042941339 0.35746248467624 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.399707970579729 0.521241353845682 -0.766838562655691 0.443177505444146 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) -0.311348682712331 0.275386899791518 -1.13058639662249 0.258229215748814 1 FALSE PrevotellaPrevotella denticola (SP60) 0.777405082693445 0.486419374047507 1.59821981642022 0.109994065044058 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.000912496023481502 0.506878830517164 -0.00180022515943404 0.998563628915153 1 FALSE TreponemaTreponema socranskii (SP63) -0.120405919780273 0.443796128435268 -0.271309081052147 0.786153322650097 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.812807726048197 0.470255736074733 -1.7284376642224 0.0839097877899512 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.0647918274463158 0.290825462925006 -0.222785951390451 0.823702102407191 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.512354361931168 0.366686471371746 -1.39725460831562 0.162337020467162 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.0748089737161905 0.345492189998905 0.216528696976993 0.828575658728893 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.0358600481634569 0.379590333249346 0.0944703935331805 0.924735499779708 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.623851429831484 0.324556469402409 1.92216605936142 0.0545848660428816 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.626219134482142 0.328114276302128 1.90853973664199 0.0563214923840685 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.710825643320453 0.441817673165741 -1.60886647704062 0.107645541049884 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) -0.110949772489624 0.369826116253478 -0.300005239255681 0.764173159248678 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.071050411267199 0.363095378831268 -0.195679745349269 0.84486083879052 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.12179589351647 0.353996004947872 0.344060079249777 0.730801104269944 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.308004014393615 0.453076064827167 0.679806412883692 0.49662704559077 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.251273900400044 0.519224635342596 0.483940636280187 0.628427999888036 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.255474450454736 0.4059790629437 -0.629279866312131 0.5291658500398 1 FALSE VeillonellaVeillonella parvula (SP88) -0.350544411706041 0.462275134494825 -0.758302546575681 0.448269883124378 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.520311493244534 0.370065782735312 1.40599730512422 0.159724925002167 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.389088565638235 0.323786426556791 1.20168275667353 0.229486464392603 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.692575953909957 0.49122602862272 1.40989262285586 0.158571391308879 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.0113077954459464 0.392515544361479 0.0288085290083001 0.977017298539516 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.502504046680782 0.313688926328168 1.60191834809968 0.109173666559414 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.0407991713679185 0.283745834302813 -0.14378773689547 0.885668086782663 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.34005532000465 0.446066839838398 0.762341626039375 0.445856136071991 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 0.123155953262517 0.395669468891611 0.311259682500936 0.75560321465032 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.404769965742117 0.392403549760477 1.03151453647448 0.302299594989999 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.081439692929634 0.352674165419844 -0.230920495218819 0.817376568118409 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.105298446931751 0.41715510282228 -0.252420373667611 0.80071615398625 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.105056741148821 0.419428591702657 -0.250475869378256 0.802219363504913 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.244397213684147 0.352558102408176 0.693211167222573 0.488177041081794 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.361997675710853 0.37884176359946 0.955537932965554 0.339305732009953 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.51116745951807 0.505177809096291 1.01185651925704 0.311606661488417 1 FALSE