Group24 Weeks.B.Plaque 1...1 Group24 Weeks.B.Plaque 1...2 Group24 Weeks.B.Plaque 1...3 Group24 Weeks.B.Plaque 1...4 Group24 Weeks.B.Plaque 1...5 Group24 Weeks.B.Plaque 1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.157104642832508 0.284552070716053 -0.552112105307005 0.580871548682518 1 FALSE StreptococcusStreptococcus mutans (SP100) 0.0463861330406009 0.620903206481214 0.0747075108590284 0.940447431575005 1 FALSE TannerellaTannerella forsythia (SP101) 0.164764660383418 0.392111705528255 0.420198270187946 0.674340618330503 1 FALSE PrevotellaPrevotella oralis (SP104) -0.165243224243731 0.337121690795051 -0.490158980438279 0.62402140472552 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.00932998717947242 0.347645037350335 -0.0268376826276114 0.978589197642948 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.221727832257151 0.465083964586859 -0.476747961960192 0.63354160531675 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.150473875854208 0.420984051259452 -0.357433673328094 0.720767171779468 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.0501863814323448 0.47655018360381 -0.105311849956328 0.916128360358556 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.200261830588473 0.477067944386518 -0.419776329440869 0.674648858382698 1 FALSE PrevotellaPrevotella salivae (SP111) 0.0899129870870524 0.30867171953191 0.291290006170317 0.770829530139176 1 FALSE VeillonellaVeillonella atypica (SP116) 0.320343153260923 0.373222371055494 0.858317127011904 0.390717374683889 1 FALSE CatonellaCatonella morbi (SP118) 0.200291355872696 0.361697020377965 0.553754508852178 0.579746865147884 1 FALSE PrevotellaPrevotella oris (SP12) 0.476117003536781 0.476901703293163 0.998354588060887 0.318107446007507 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.311321372677117 0.404556768181568 0.769536928220156 0.441574630975811 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.509100689652245 0.382225299186881 -1.33193875637031 0.182880314209549 1 FALSE CampylobacterCampylobacter showae (SP122) 0.542723314132561 0.349447816315512 1.55308829757443 0.120402041462505 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 0.0964513660320526 0.385064175721314 0.250481275884408 0.802215182958492 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.232386984476995 0.394710094298333 -0.588753588605592 0.556026583721438 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.650571891453102 0.409909717805147 -1.58711019328006 0.112487689664437 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.266788050582581 0.326271737694711 -0.81768666960732 0.413536124131734 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.403918463642696 0.414386649682564 -0.974738119464305 0.329690179097712 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.519463936568785 0.271036505315248 -1.91658291920709 0.0552909397033965 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 1.17538113834193 0.577740043723873 2.03444637620392 0.0419066100166427 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.746565104628198 0.414828724533059 1.79969481493488 0.071908840281788 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.206972290293587 0.368876497558189 -0.56108830913235 0.574737337512542 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.238428312284318 0.525593224055217 0.45363657933929 0.650090420911458 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.121611591932881 0.515357134419702 -0.235975372825327 0.813451780218295 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.567703221469996 0.37346146450296 -1.52011191362287 0.128482850860592 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.139971849504977 0.309688064374759 0.451976894193747 0.651285628038824 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.0965457524869253 0.447766641623088 -0.215616223970953 0.82928690835716 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.0717668771358236 0.404982894272405 -0.177209650458844 0.859343715662783 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) 0.0639732224300703 0.292793409198577 0.21849269969968 0.827045245721392 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.045507949361304 0.505847998804879 0.0899636836931676 0.928316073980967 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.660152974317969 0.602650295566554 1.09541632879704 0.273334283637941 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.123759989822128 0.396329588947035 -0.312265329850675 0.754838886340766 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.444468412789148 0.510828135623254 0.870093837425102 0.384249125193035 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.0117590720022348 0.395009895226737 0.0297690567865018 0.976251236931592 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.38047868640511 0.489080960822521 -0.77794622339261 0.436600716684031 1 FALSE KingellaKingella oralis (SP176) 0.655083448654395 0.453266611534302 1.44524973158059 0.148387752010717 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.042264930454803 0.456479912546263 0.0925888068525239 0.926230236385702 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) -0.455523857544082 0.328192507455003 -1.38797762653536 0.165143858081149 1 FALSE GemellaGemella haemolysans (SP183) -0.729597671584607 0.344592078983964 -2.11727928783459 0.0342361516706094 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.204647599658142 0.333334495902474 -0.613940657729038 0.539254541868758 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 0.591265767571322 0.519262419042437 1.13866466335396 0.254843046666449 1 FALSE RothiaRothia dentocariosa (SP193) 0.257708539022927 0.56237160816299 0.458253111078531 0.646770606735084 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.13799186596869 0.389307336561771 -0.354454830436506 0.722998049496118 1 FALSE EikenellaEikenella corrodens (SP200) 0.587460324414344 0.360171265422653 1.6310582792466 0.102878022862461 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.378192450593653 0.595248748592205 -0.635351945700177 0.525198901627287 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.234073265880226 0.427222241011967 -0.547895786805886 0.583763461953494 1 FALSE CampylobacterCampylobacter gracilis (SP205) 1.356594544673 0.403633027127654 3.36096021261401 0.000776720134694665 0.111070979261337 FALSE SelenomonasSelenomonas sputigena (SP21) -0.415686992015141 0.431047783661248 -0.964364063038127 0.33486343280459 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.694590220717161 0.494518683701141 -1.40457831748362 0.160146707924667 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.557720478164335 0.457466181837953 1.2191512734856 0.22278678209488 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.138948986662427 0.286533925399854 -0.484930314860714 0.627725777619748 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) -0.0414880304434375 0.310756670012736 -0.133506484162471 0.8937928365579 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.251734033948702 0.441992171149213 -0.569544101412869 0.56898695085225 1 FALSE FilifactorFilifactor alocis (SP234) -0.145856141126966 0.331067549753683 -0.440563085193592 0.659529332278743 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.306386041363684 0.525184759272989 0.583387152719004 0.559632704434309 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.241211367788976 0.328898659113907 0.733391155922705 0.463319891776553 1 FALSE LautropiaLautropia mirabilis (SP245) 0.737583875688474 0.45863595589549 1.60821206058373 0.107788742634335 1 FALSE ActinomycesActinomyces oris (SP249) -0.0451894892438441 0.515163368179217 -0.0877187549331408 0.930100212802451 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) -0.424802417575474 0.291564959907491 -1.45697349129421 0.145123697777079 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.114673253685592 0.294067097525455 -0.389956083664429 0.696569021376215 1 FALSE ArachniaArachnia propionica (SP260) -0.179397769612828 0.371713159913712 -0.482624208554985 0.629362586887902 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.38196177548188 0.469922300761892 -0.812819001912869 0.416321839298233 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.201039600818192 0.359265823728425 0.559584540304511 0.575762852216854 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.331295263932717 0.446742455745882 -0.741579985675607 0.458341853516595 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) -0.587581963340625 0.31112717177891 -1.88855881657989 0.0589509697723833 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.0468975363238738 0.321289184103237 -0.145966744740478 0.883947641052919 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.0374929613159716 0.33260293448978 0.112725888523763 0.910247875990661 1 FALSE DialisterDialister invisus (SP28) 0.547387782009436 0.458402900044118 1.19411936956933 0.232431277414603 1 FALSE ActinomycesActinomyces dentalis (SP286) 0.149840254805248 0.495490064233934 0.302408192658539 0.762340910107583 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.095605709948591 0.36149270100407 0.2644748004124 0.791414080072314 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.0865147234795287 0.41055409497639 -0.210726733792544 0.8331005124451 1 FALSE ActinomycesActinomyces israelii (SP293) 0.199150847905109 0.479603489138094 0.415240615248667 0.677965769067181 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.294255357211299 0.340774382163608 -0.863490252239752 0.387867976592345 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.164483094534175 0.334273908208152 -0.492060823460236 0.622676346244163 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.200424275741099 0.395893017833815 0.506258677755292 0.612675067493696 1 FALSE ParvimonasParvimonas micra (SP31) -0.107995627037816 0.452212105216658 -0.23881631162013 0.811248021311962 1 FALSE ActinomycesActinomyces massiliensis (SP310) 0.362544507575855 0.417912392769005 0.867513177041022 0.385660895058843 1 FALSE TreponemaTreponema denticola (SP311) 0.0251565273913718 0.31398822726519 0.080119333168899 0.93614234653035 1 FALSE RothiaRothia mucilaginosa (SP318) -0.2210195501255 0.430860171141211 -0.512972804007595 0.607970344681273 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.256330858394662 0.339588261191861 -0.754828383922964 0.450351960778688 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.442582443893815 0.326378429408408 1.35604073068198 0.175086208997033 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.0337471862481012 0.367327168751899 0.0918722847612039 0.926799511867879 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.099888667843746 0.346578924456297 0.288213335535185 0.773183441422217 1 FALSE GemellaGemella morbillorum (SP332) -0.0525239078897392 0.319074132103456 -0.164613494498855 0.869248209049196 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.588480496173002 0.404285312632886 1.45560691369309 0.145501315719299 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.203224056195644 0.43248832803749 0.469894892002791 0.638430113896839 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.0945847006372646 0.671242784860377 -0.140909820962826 0.887941183556892 1 FALSE NeisseriaNeisseria elongata (SP369) 0.584909506433226 0.343170518580983 1.70442819171017 0.0883011208174045 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.0153775095791533 0.39354885108349 -0.0390739536827946 0.968831427055763 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.754330584734839 0.32497752616656 2.32117769383297 0.0202772555469844 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.117734760922321 0.413271031635217 -0.284885104229232 0.775732168423997 1 FALSE OlsenellaOlsenella uli (SP417) -0.260947760142757 0.347307764969447 -0.75134444565532 0.452445387272816 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.0662730801800282 0.346983305444153 -0.190997892809845 0.848527244062223 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.0313832496483356 0.462577022832539 -0.0678443763941488 0.945909517864678 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.0377329297917971 0.389785742630522 0.0968042841617328 0.922881821647485 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) -0.00596931534012968 0.387290450213549 -0.015413019703528 0.987702676439574 1 FALSE GemellaGemella moribillum (SP45) 0.111441764992136 0.357532574366036 0.311696815848851 0.755270948075537 1 FALSE RothiaRothia aeria (SP465) 0.437164227593755 0.462952299842217 0.944296480960887 0.345018163716875 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.385941973004487 0.493614791420478 0.781868735930419 0.434291720310482 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.326545954462423 0.574751972001711 -0.568151081457187 0.569932384870744 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.649111987809199 0.485624035496881 1.33665539668983 0.181335147548265 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.181693869745006 0.512042888593003 0.354841115446924 0.722708624403666 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.190070289246778 0.346749198986577 0.548149180451707 0.58358947357337 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.0500042977628119 0.293315172894261 -0.170479751420286 0.864632857288127 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.486530394728738 0.559156746564451 0.870114503165809 0.384237832619453 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.097440102531478 0.528625444538833 0.184327303080319 0.853756696125253 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.391019176292766 0.338928600025116 1.15369188750607 0.24862651103503 1 FALSE PrevotellaPrevotella denticola (SP60) 0.277818647812946 0.495045247367853 0.561198495067074 0.574662228771605 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.24570274103526 0.502823860045123 0.488645747664422 0.625092519027181 1 FALSE TreponemaTreponema socranskii (SP63) 0.358665415665479 0.428323294845501 0.837370789732209 0.402384179545091 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.28806739676938 0.498375421466044 0.578012848069409 0.563255445003104 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.295733606187695 0.288658623091673 -1.02450986227345 0.305594515000642 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.490335917242924 0.376381827083002 -1.30276193471688 0.192656050034504 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.365503223460824 0.401439467974913 0.910481536119574 0.362568614792437 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.64464622065124 0.466256354333055 1.38260039709991 0.166787427247694 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.0195625826453083 0.281367510614898 0.0695268000294575 0.944570300926263 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.189211994632938 0.304037513715069 0.622331081191049 0.533724187748346 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.399558984376896 0.455834052161747 -0.876544835740172 0.380733913319558 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) -0.0232832680400777 0.399179985298055 -0.0583277441194673 0.953487568518068 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.335952294228135 0.374558412818825 -0.896928977512078 0.369756816321713 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.580817530307141 0.388154546397401 1.49635637582482 0.134560811244238 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.075882721422925 0.444034768894151 0.170893647837325 0.864307391481345 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.906312694846666 0.507731058680974 1.78502512176655 0.0742572421354032 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.381443710576154 0.437926610647661 0.871021996155994 0.383742143010625 1 FALSE VeillonellaVeillonella parvula (SP88) 0.194698382338047 0.402678636381329 0.48350809987762 0.628735009943149 1 FALSE PrevotellaPrevotella oulorum (SP9) -0.185674550151111 0.328634905390936 -0.564987306902891 0.572082397749537 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.222674723557514 0.28051909602381 -0.793795241442719 0.427314643351809 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.655489447982971 0.500247011440615 1.31033156219222 0.190083694606613 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.118783706650481 0.399613361905914 0.297246583757746 0.766278259441705 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.137238977544378 0.258850201760117 -0.530186867196498 0.595982375555758 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.419872264861221 0.268912680137855 -1.56137027322765 0.118436411586453 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.418982185062905 0.429451345634202 0.975622010088624 0.329251813222495 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 0.164039622604551 0.454000448586041 0.36132039762393 0.717859947145846 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.0104185787120362 0.36494955478301 0.0285479967724056 0.977225087722614 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.558209392215833 0.337439555514217 -1.65425002224529 0.0980767229961273 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.234054710269259 0.403114846414004 -0.58061545574752 0.561499653222763 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.495784961671952 0.465025473003965 1.06614581448471 0.286357732044055 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.508683171603762 0.398540292524274 1.27636573050586 0.201826264503421 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.416513379958503 0.402953595238653 1.03365098333921 0.301299355773916 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.171905343418683 0.491824243636042 0.349525965104509 0.726694481186309 1 FALSE