Group24 Weeks.B.Plaque 2...1 Group24 Weeks.B.Plaque 2...2 Group24 Weeks.B.Plaque 2...3 Group24 Weeks.B.Plaque 2...4 Group24 Weeks.B.Plaque 2...5 Group24 Weeks.B.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.382029514545457 0.338820126398131 -1.12752898892598 0.259518891094243 1 FALSE StreptococcusStreptococcus mutans (SP100) 0.632536355890109 0.594561310059248 1.06387069792193 0.287387278808518 1 FALSE TannerellaTannerella forsythia (SP101) 0.467736057100272 0.446467487702479 1.04763744277829 0.294805679561569 1 FALSE PrevotellaPrevotella oralis (SP104) 0.433003727423353 0.335393295035349 1.29103274821793 0.196692322089463 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.349208645984969 0.40162171524806 -0.869496425932252 0.384575662106987 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 0.151318356219901 0.455422827999466 0.332259050088896 0.739693658358715 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.0971316269373943 0.469561394465663 -0.206856074801305 0.836122261737486 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 0.0356980703593512 0.421831023073279 0.0846264698581684 0.932558354646056 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.315256946277579 0.504714356355537 -0.624624487708255 0.532217543969724 1 FALSE PrevotellaPrevotella salivae (SP111) -0.343102317073448 0.376092466315148 -0.912281813127159 0.361620385662584 1 FALSE CatonellaCatonella morbi (SP118) -0.335435003281465 0.415864654014055 -0.806596569445712 0.419898950847308 1 FALSE PrevotellaPrevotella oris (SP12) -0.400939801504268 0.50992630817509 -0.786270084669959 0.431709274490818 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.114510742541154 0.463055092232121 -0.247293992576919 0.804680707669297 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.154772017257344 0.30499007906485 -0.50746574358058 0.611828066635533 1 FALSE CampylobacterCampylobacter showae (SP122) -0.347595039160166 0.405209555672556 -0.857815503840322 0.390994347378896 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.567279694374702 0.36522378181242 -1.55323865154558 0.120366130501077 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.370146263456326 0.425665405223643 -0.869570932742003 0.384534928447511 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.13520187119637 0.500963140236842 0.269883870363098 0.787249596474758 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.665073783250102 0.408452298244728 -1.62827773551079 0.103466008222449 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.0980160496074741 0.458290254131945 -0.213873301305802 0.830645860971892 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.0389305356990099 0.375858463759594 0.103577648111473 0.917504526461231 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.271298286782453 0.606793242186742 0.44710169448288 0.65480163562886 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.568856637453874 0.420042866589581 1.35428234282978 0.175646317228176 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.210569133498313 0.405090355923151 0.519807816748567 0.603197530634844 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.031282059356163 0.387115540717163 0.080808069079868 0.935594590861131 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.18206993957409 0.580194394497499 0.313808511941552 0.753666479132321 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.607165883668404 0.50455536027545 -1.20336821580279 0.228833861893521 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.214155779010068 0.344302953917931 -0.621998087942967 0.53394312528604 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.2451589027227 0.343606554462649 0.713487270654932 0.475544287250747 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.360822584261866 0.491894149489004 -0.73353705189765 0.463230937924548 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.32296368289291 0.421882682680963 -0.76552960372906 0.443956245251038 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.00141343219411854 0.323733422425005 -0.00436603728935641 0.996516417322442 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.0706562979010929 0.338244036936573 -0.208891481254235 0.834532954441314 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.316335532461583 0.490613662940282 -0.644775220008676 0.519072862548838 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.0707067764020268 0.653532634920276 -0.108191653521101 0.91384366561807 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.734953868191752 0.462933598572544 1.58760105219838 0.11237658013381 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.064745364318331 0.409907605758703 0.157951117297502 0.87449531781118 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.129177767082349 0.418601058418213 0.308593981034064 0.757630399985959 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.3879607942569 0.510525258607957 -0.759924778873327 0.447299549198594 1 FALSE KingellaKingella oralis (SP176) 0.074144386159146 0.492516401683872 0.150541963487211 0.880337045872584 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.294724225698462 0.424268473900856 0.694664449113262 0.487265612342317 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.245049471793133 0.392144787847681 0.624895394219334 0.53203971541021 1 FALSE GemellaGemella haemolysans (SP183) 0.0810828977069742 0.362359383611963 0.22376375878209 0.822941131225137 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.320386037282128 0.331318567146078 -0.96700296648594 0.333542550702415 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 0.201394273671999 0.552279649811157 0.364659957579212 0.715365252443902 1 FALSE RothiaRothia dentocariosa (SP193) 0.640886263778293 0.583039286854247 1.09921625905547 0.271673748439323 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.241461408159892 0.444072456195202 0.543743267098178 0.586618154002106 1 FALSE EikenellaEikenella corrodens (SP200) 0.117615552089603 0.37314223287716 0.315203002304815 0.752607526161867 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.00279523429576248 0.581226646769746 -0.0048091984620757 0.996162829588541 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.453091242424471 0.459811541409678 0.985384666586218 0.324435158523353 1 FALSE PrevotellaPrevotella multiformis (SP204) 0.228677065605861 0.35254535420521 0.64864580649885 0.516567340579977 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.43870904359235 0.428198630238086 1.02454564917319 0.305577620942287 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.344438594074859 0.467757597668722 -0.736361302930241 0.46151084802597 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.389593241267991 0.509345941186678 -0.764889262414292 0.444337488355296 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.485912020603359 0.489604686688954 -0.99245786205486 0.320974225123378 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.374391898245733 0.363244986847417 1.03068703437605 0.302687606838841 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.524560843412081 0.369984948228346 1.41778968556401 0.156252176417171 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.652240122841658 0.461935208362828 -1.41197317509808 0.157957859787843 1 FALSE FilifactorFilifactor alocis (SP234) -0.180307708528735 0.409651094171569 -0.440149461564037 0.65982886038912 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.700519560032661 0.555884096797079 1.26018996418309 0.207600842322277 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.184913862648789 0.368717496906177 0.501505527132177 0.61601538894637 1 FALSE LautropiaLautropia mirabilis (SP245) 0.149880757692507 0.519234697254429 0.288657053322968 0.772843830723987 1 FALSE ActinomycesActinomyces oris (SP249) 0.288134053359146 0.511394489623582 0.563428154204849 0.573143370236566 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.10341645088629 0.350806147175061 -0.294796575599008 0.768149282527564 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.709054630958469 0.362333844189075 1.95690974588746 0.0503580805277419 1 FALSE ArachniaArachnia propionica (SP260) -0.0875659540636515 0.363445481165105 -0.24093284578182 0.80960716460754 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.609630561077604 0.502081913617681 1.21420538072164 0.224669306318833 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.0494539089246733 0.386343833725837 0.12800491326016 0.898145084811389 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.519106806342926 0.476258238404289 -1.08996918999701 0.275726716145522 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) 0.31914983005245 0.318850653027432 1.00093829829789 0.316856639456891 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) 0.258207564076272 0.380454391107124 0.678682044712078 0.497339345318997 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.318299197151535 0.312017381159123 -1.02013290403591 0.307665433430878 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.0411209948064251 0.386917329404593 0.106278503652716 0.915361386583786 1 FALSE DialisterDialister invisus (SP28) -0.453587059813056 0.501421739396078 -0.904601903298737 0.365676326659457 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.0374994293936738 0.497347267122179 -0.0753988849896739 0.939897346335478 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.167366176497815 0.40559064961973 0.412648015073159 0.679864517155527 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.624966302214064 0.457454654321533 -1.36618197303288 0.17188185421073 1 FALSE ActinomycesActinomyces israelii (SP293) 0.205931692956748 0.479307005677347 0.42964465471505 0.667454148760683 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.426896161030067 0.370974956038783 1.15074118638197 0.249838727051891 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.0301455459230582 0.425740965441219 -0.0708072475285921 0.943551163611801 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.157607409540306 0.492978016245098 0.319704742091273 0.749192164645138 1 FALSE ParvimonasParvimonas micra (SP31) -0.338948007698865 0.490284208926273 -0.691329644169377 0.489358406610092 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.0372166591229604 0.361893324073862 -0.102838755642158 0.918090945759855 1 FALSE TreponemaTreponema denticola (SP311) -0.35308920645149 0.367549956784436 -0.960656367750774 0.33672497655175 1 FALSE RothiaRothia mucilaginosa (SP318) -0.295395413592782 0.537019150421718 -0.550064952731779 0.582274824092011 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.0277002208541627 0.343288447295883 -0.0806908041105377 0.935687850225942 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.588536556449808 0.39538366479574 1.48852016118029 0.136613769258386 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.488799107482309 0.411382248496051 -1.18818716478234 0.234759679319783 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.00408608436246673 0.442711747110323 0.00922967232999237 0.992635891500981 1 FALSE GemellaGemella morbillorum (SP332) -0.180603493084242 0.375914688456656 -0.480437446660364 0.630916372662173 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.166639020828538 0.474553016851935 0.351149428854081 0.725476247168356 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.953582416923316 0.455880567246126 2.09173736595902 0.0364620159926308 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.437820775123681 0.372582172552789 -1.17509856181229 0.239955285988052 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.164968510599092 0.668584766712072 0.246742849691842 0.805107242350891 1 FALSE NeisseriaNeisseria elongata (SP369) 0.321196463463371 0.394126934557086 0.814956896626023 0.415096983217489 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.270099486883307 0.339738251489547 -0.795022302313867 0.426600529055059 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.172604771127196 0.339783775053158 -0.507984146977566 0.611464460939857 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.193591809548672 0.444042549096424 0.435975808945808 0.662854281235781 1 FALSE AlloprevotellaAlloprevotella rava (SP42) 0.0270517839468575 0.36232069461716 0.0746625416343975 0.940483211897075 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.536452126221058 0.39854046725961 1.34604179572965 0.178289037800878 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.29787361348877 0.463219811131239 0.643050245975721 0.520191497074434 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) -0.149395304546827 0.455034299042846 -0.328316579345945 0.742672309821985 1 FALSE GemellaGemella moribillum (SP45) 0.125468537265073 0.378642771132826 0.331363878649249 0.740369645765133 1 FALSE RothiaRothia aeria (SP465) 0.650024261139095 0.452819087087448 1.43550543622196 0.151143120342361 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.633238285708693 0.54750098943929 -1.15659751840304 0.247436836623945 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.550476650007663 0.589010546863732 -0.934578596153756 0.35000551379928 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.476868198396879 0.53063953962271 -0.898666915654151 0.36883010439347 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.548546489290757 0.582683671999177 -0.941413867680047 0.346492809687318 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.0849438166721502 0.41660535797316 0.203895161323448 0.838435426359752 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.381226028205227 0.353837179349411 1.07740523171187 0.281299267880626 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.0538309986246934 0.634324093652975 0.0848635566003633 0.932369864852206 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.46876728310735 0.504623355032591 0.928944882222256 0.352917651441624 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.245238985125263 0.371016221620602 0.660992621977705 0.50861704513147 1 FALSE PrevotellaPrevotella denticola (SP60) -1.03524110446204 0.533003123433495 -1.94227962078952 0.0521032587397068 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.00202821149735978 0.537937037007214 0.00377035109655886 0.996991702198684 1 FALSE TreponemaTreponema socranskii (SP63) -0.133669622237677 0.441145888707032 -0.303005481088023 0.761885684540703 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.0907168482399552 0.580328923091218 -0.156319708755402 0.875781021965286 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.0227240202118499 0.314787490613285 -0.0721884474112293 0.942451938817688 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.141860319987749 0.430865761472466 -0.329244819785512 0.741970648363581 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.40301774219347 0.411802433359053 0.978667704573949 0.327744194286122 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.697460213873193 0.492498611430927 1.41616686359127 0.15672665520552 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.32862906648096 0.362621019048401 -0.906260390926475 0.364798045083233 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.259880857020591 0.334300581331201 -0.77738679360273 0.436930601673055 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) 0.187565661274629 0.399057292818287 0.470021885704613 0.638339381389636 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) -0.144888904333113 0.424061307886144 -0.341669710578768 0.732599469198187 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.129774000709198 0.464128118338446 0.279608141764352 0.779778159944046 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.408321572635219 0.422069611870277 -0.967427081106035 0.333330577482644 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.445532436800205 0.478411828595145 0.931273873617442 0.351711913009883 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.583125892775232 0.553706655512638 1.05313144960368 0.292280750760106 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.132091408197626 0.465885403559088 -0.283527681246345 0.776772365276651 1 FALSE VeillonellaVeillonella parvula (SP88) 0.0689446441780894 0.414885697370678 0.166177442642693 0.868017310779787 1 FALSE PrevotellaPrevotella oulorum (SP9) -0.13559201195856 0.434702925138295 -0.311918793542563 0.755102239387185 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.36071898127292 0.36201953413018 -0.996407506406014 0.31905218728837 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.190858030727648 0.575138947985769 -0.331846819618223 0.740004928654523 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.508557424489425 0.417761057368376 1.2173404282654 0.223474718379898 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0205468177504872 0.364515180319366 -0.0563675228353598 0.955049028827475 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.301225812163671 0.337242807696487 -0.893201590335379 0.371749226598849 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.764599188423717 0.474350722187996 -1.61188578968936 0.106986795007667 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 0.103606463313023 0.453437703385802 0.228491064019154 0.819264502284679 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.317266502775878 0.430387478684781 -0.737164807269513 0.461022132134787 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.159814006867476 0.349056276460527 0.457845962513579 0.647063111833238 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.0373397097270566 0.44683106431648 0.0835656083673936 0.933401811806689 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.0334535945797443 0.481292951690953 -0.0695077591770459 0.944585456662945 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.377052151568004 0.478133347944747 0.788592038578276 0.430350485633778 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.116816230510431 0.449230264412508 -0.260036421774031 0.794835679184467 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -0.0378087465323848 0.545361920183384 -0.0693278080722452 0.944728691343186 1 FALSE