GroupBaseline.A.Plaque 2...1 GroupBaseline.A.Plaque 2...2 GroupBaseline.A.Plaque 2...3 GroupBaseline.A.Plaque 2...4 GroupBaseline.A.Plaque 2...5 GroupBaseline.A.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.243460060341823 0.257645976471143 0.944940276872871 0.344689367395981 1 FALSE StreptococcusStreptococcus mutans (SP100) 0.352000491639016 0.455427783648455 0.772900785321269 0.439581099940183 1 FALSE TannerellaTannerella forsythia (SP101) 0.343497948882356 0.276089563318224 1.24415405187351 0.213442870866382 1 FALSE PrevotellaPrevotella oralis (SP104) 0.102365615903035 0.236604922037678 0.432643645032599 0.66527367674464 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.182017482635273 0.337418592585868 0.539441176730509 0.589582475210785 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.393904961479872 0.378939318721862 -1.03949350732061 0.298575276103438 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.309140639912575 0.334066786401034 -0.925385738711133 0.354765294392141 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.624317360373352 0.274639603930723 -2.2732240778021 0.0230126800324735 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.2580515573712 0.402249656850866 -0.641520888772002 0.521184313732769 1 FALSE PrevotellaPrevotella salivae (SP111) 0.273917644487133 0.283449583427726 0.966371660083871 0.33385823977821 1 FALSE VeillonellaVeillonella atypica (SP116) -0.166126914919454 0.279956284350826 -0.593403056854667 0.552911443620233 1 FALSE CatonellaCatonella morbi (SP118) 0.103933149883509 0.298956948356361 0.347652564875725 0.728101124679166 1 FALSE PrevotellaPrevotella oris (SP12) 0.554100171640353 0.383087762038597 1.44640530590619 0.148063554525621 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.396399332584871 0.33816192373877 1.1722175229021 0.241109734948389 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.567094121709629 0.239120582660749 -2.37158221763867 0.0177121055302913 1 FALSE CampylobacterCampylobacter showae (SP122) 0.347807497041088 0.278003839869477 1.25108882382482 0.210902072609592 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 0.174691495627744 0.302573691723552 0.577351899408861 0.563701760609861 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) 0.349728759201692 0.325396246339028 1.07477809942931 0.282474087852999 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0811735286941826 0.393051414122755 0.206521400960616 0.836383649496984 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.577390484936813 0.281300969205436 2.05257197146427 0.0401141082268301 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.0365926377208517 0.363455749903998 -0.100679760137286 0.919804678792887 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.195142246691203 0.254347364231966 -0.767227320324155 0.44294637203621 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.0969055990486683 0.412409368344971 0.234974291291097 0.814228687207681 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.448687464665425 0.351029091577538 1.27820592489644 0.201176827599541 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.00736329966445187 0.265889056560798 0.02769312795229 0.97790690470279 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.18542440005006 0.273734283770199 0.677388296037207 0.498159622243704 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.255225399710667 0.424764372625573 0.60086348140042 0.547930918123755 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.872329717806199 0.37581168820022 2.32118836426783 0.0202766798995276 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) -0.0194660186649554 0.227293582978304 -0.0856426231215401 0.931750514559967 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.513643900416716 0.356127761237921 1.44230233170045 0.149217102697247 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.0591305153844312 0.316954605322874 0.186558309585678 0.852006956902563 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.331107026691534 0.269914009184205 -1.22671301016305 0.21993047604425 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.39554572222155 0.251248549186519 -1.57432042295261 0.115413390568535 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.249044972612639 0.369456726902565 -0.674084282347681 0.500257731600451 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -1.28606047582295 0.455889487310329 -2.82099173510337 0.0047875436310915 0.646318390197353 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.537522751696972 0.305875431400443 -1.75732568397513 0.0788623123910217 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.472412536125984 0.351948166005473 -1.34227872668794 0.179505638403726 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.362035344568644 0.326005149515085 -1.11052032493092 0.266774874726184 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.00810563920629473 0.410931127869758 -0.0197250552624569 0.984262703457185 1 FALSE KingellaKingella oralis (SP176) -0.151571691582028 0.314544340024386 -0.481877027481329 0.629893306241442 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.362981976273772 0.365339738618186 -0.993546384104475 0.320443757897853 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) -0.291562841543899 0.236066301558383 -1.23508878488441 0.216797462858025 1 FALSE GemellaGemella haemolysans (SP183) 0.284977066279242 0.313756156877289 0.908275614781632 0.36373262274047 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.305296103579878 0.290045740252856 1.05257916669877 0.292533909550706 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -1.01454308596714 0.410595699130899 -2.47090529227316 0.0134771505715282 1 FALSE RothiaRothia dentocariosa (SP193) -1.09188526891228 0.472308904280436 -2.31180326904014 0.0207885271965168 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.477453153247903 0.265578740851793 -1.79778378237867 0.0722112783234585 1 FALSE EikenellaEikenella corrodens (SP200) 0.117491804072443 0.25548400971966 0.45987928638417 0.645602868795611 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.053286043669085 0.400973872668387 0.132891560526073 0.894279141428866 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.492126395677508 0.317363640423761 -1.55067037616658 0.120980697234981 1 FALSE PrevotellaPrevotella multiformis (SP204) 0.119208316256206 0.255793350949701 0.466033678411161 0.641191394095027 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.205233911440823 0.361056955802496 0.568425308369046 0.569746209549306 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.281993031156492 0.371013849840413 -0.760060658861625 0.447218327191169 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.443839596374418 0.411593405333747 1.07834477088991 0.280879924162612 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.0855306479054891 0.355422959331761 -0.240644690107519 0.809830510107257 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.393623355657498 0.296339254638587 1.32828624455291 0.184083562180692 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.536099788161207 0.350741074822165 1.52847734880502 0.126394063259951 1 FALSE FilifactorFilifactor alocis (SP234) 0.276661807770609 0.277210199981847 0.998021745912404 0.318268813961839 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) -0.751751100177129 0.423163499024975 -1.77650270382314 0.0756500966625584 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) -0.063973336996091 0.241840229027796 -0.264527275934469 0.791373649951891 1 FALSE LautropiaLautropia mirabilis (SP245) -0.103495877507209 0.315422664653051 -0.328118074904508 0.74282238807035 1 FALSE ActinomycesActinomyces oris (SP249) -0.526075175910541 0.369902433270605 -1.42219982512439 0.154968249540873 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.130920083373805 0.260061953521695 -0.503418826171678 0.614669838192395 1 FALSE ArachniaArachnia propionica (SP260) -0.445033535998734 0.292423769543962 -1.52187880175667 0.128039451639321 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.720246931780391 0.357561335398002 -2.01433113840086 0.0439747788316478 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.853334176786154 0.304624994732138 2.80126119505231 0.00509033002110351 0.677013892806766 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.668419625462506 0.37447905088018 1.78493195785304 0.0742723542227034 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) -0.133263428351523 0.255898887107174 -0.520765955092687 0.602529822219353 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.222783126477994 0.241970428237089 -0.920703939324789 0.357205018945766 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.260455434622336 0.292835193620554 -0.889426681957585 0.373773810487346 1 FALSE DialisterDialister invisus (SP28) 0.386363000122516 0.383005645529447 1.00876580967476 0.313086961879175 1 FALSE ActinomycesActinomyces dentalis (SP286) -1.30231713369615 0.369472111230606 -3.52480496933451 0.000423794681891221 0.0580598714190972 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.339381231569721 0.272289221166237 -1.24639980281307 0.212617653613349 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.312959258433813 0.38419404967182 0.814586427616835 0.415309081976387 1 FALSE ActinomycesActinomyces israelii (SP293) -0.57371734355155 0.282644494565071 -2.02981963060833 0.042374876794568 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.502051760764605 0.269887645328153 -1.86022505829849 0.0628536912002176 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.328446762074413 0.278923396108957 1.17755185350644 0.238975313794908 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.189153909867146 0.342933893491015 -0.551575430301121 0.58123927375565 1 FALSE ParvimonasParvimonas micra (SP31) 0.112499265673883 0.381790559071177 0.294662251333746 0.768251902512614 1 FALSE TreponemaTreponema denticola (SP311) 0.447270043133569 0.259609262628485 1.72285857062672 0.0849141039027076 1 FALSE RothiaRothia mucilaginosa (SP318) -0.531333730034649 0.289367243396524 -1.8361916981272 0.0663293100679874 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.0776592935898622 0.262679955178434 0.295642252326065 0.767503302532296 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.270626830040344 0.271736282075538 0.995917173714457 0.319290390244345 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.388790098510655 0.298414980618693 1.30285047253523 0.19262581545058 1 FALSE GemellaGemella morbillorum (SP332) 0.0816510587619003 0.313020451475372 0.260848958517091 0.794208987580646 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.214646049996042 0.32989901486416 0.650641682226376 0.515277816823321 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.21867270909565 0.323618382681007 0.675711643090427 0.499223742242894 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.166758768274758 0.244176059668695 -0.682944791971094 0.494641728739638 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -1.24438873263948 0.514807187804593 -2.41719378073606 0.0156406880095953 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.226296789514959 0.277494784721194 0.815499252507844 0.4147865922678 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.0517549474459477 0.275609348110677 0.187783715613174 0.851046201731184 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.248726590317401 0.304559374334729 0.816676849500076 0.414113124613524 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.507890427393327 0.2712165347162 -1.87263814105132 0.0611183707200402 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.21111380939075 0.435729918605443 -0.484506113480619 0.628026726694503 1 FALSE NeisseriaNeisseria mucosa (SP44) -0.242489742728209 0.293028804323708 -0.827528690525356 0.407937467327404 1 FALSE GemellaGemella moribillum (SP45) -0.247283297309826 0.257354101849408 -0.960867907419347 0.336618588928866 1 FALSE RothiaRothia aeria (SP465) -0.0383476424340681 0.229134709305022 -0.167358505179676 0.867087972710149 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.135663487036469 0.405839607983574 0.334278577959694 0.73816935391755 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.151037061514955 0.46988712842164 0.321432642818481 0.747882549107204 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.0716734028112592 0.397862724250677 -0.180146061549865 0.857037902192369 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.801436623044583 0.426483769611375 1.87917262074211 0.0602209267997683 1 FALSE StreptococcusStreptococcus constellatus (SP53) -0.0271460969802281 0.266934808604396 -0.101695605463202 0.918998290395138 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.412638386204703 0.287440506160716 1.43556101996976 0.151127293273774 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.288969891777073 0.438025721863786 0.659709869428479 0.509440031964643 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.315999044439834 0.408970421901834 0.772669678580531 0.43971789581146 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.130289947911334 0.233640955770274 0.557650295008381 0.577083205121697 1 FALSE PrevotellaPrevotella denticola (SP60) -0.104347164481156 0.393834310909597 -0.264951939408623 0.791046485766731 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.200737621773885 0.358118839733243 0.560533542226963 0.575115567418147 1 FALSE TreponemaTreponema socranskii (SP63) 0.259695016475673 0.354376349954467 0.732822651706415 0.463666603790577 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.471446510863361 0.437444089594884 -1.07772975353254 0.28115437632428 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.270921353498702 0.288287329238858 0.939761571255993 0.347339874639473 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.175156429392137 0.288870502852614 -0.606349307604814 0.544282822725475 1 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.392163159487981 0.296252001998663 -1.32374855475154 0.185586566905092 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.0520679634063181 0.303003443321742 0.171839510586123 0.86356370255948 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.0678737154055981 0.314171263633475 0.216040495303805 0.828956182142744 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.409167370459297 0.230384846615024 -1.77601685384725 0.0757301392753095 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -1.48744851854075 0.316456556542891 -4.70032453993145 2.59748353432424e-06 0.000358452727736745 TRUE PrevotellaPrevotella melaninogenica (SP79) -0.0438670768769083 0.300560576297567 -0.145950867599742 0.883960174953828 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.305886528297452 0.340191121467021 0.899160821653325 0.368567005288078 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.318960976282108 0.354748237570436 -0.899119269672982 0.368589135139017 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.0881071152148668 0.423096595556953 -0.208243498388081 0.835038846177657 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.0259454752522113 0.325919218095043 -0.0796070738137486 0.936549768985584 1 FALSE VeillonellaVeillonella parvula (SP88) 0.841670607941034 0.299197795392462 2.81309094151915 0.00490677718682566 0.657508143034639 FALSE PrevotellaPrevotella oulorum (SP9) -0.35482101054668 0.314195873885219 -1.12929875927111 0.258771824136961 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.0319433623254806 0.234126775221662 0.136436177772653 0.891476475340048 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.164619582426996 0.403265894008271 -0.408215980753433 0.683115116676602 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.487307351903569 0.329006602656711 -1.4811476364565 0.138567236248284 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0208025037839182 0.274701561504062 -0.0757276502908069 0.939635777399846 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.281635807818979 0.284814961654884 0.988837827137195 0.322742493470498 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.417658270588497 0.374101636098062 -1.11642994921043 0.264238139750209 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.775409342277976 0.2624115896938 -2.95493557728443 0.00312734346736504 0.425318711561645 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.511761711495652 0.301323805665657 -1.69837796374938 0.0894364484491836 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.299562110878826 0.315615754164648 -0.949135481755935 0.342551710377951 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.0522240524512361 0.318206407770293 0.164120052820984 0.869636635987305 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.419625715290236 0.365847659739315 -1.14699576208644 0.25138337243094 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.359215668871072 0.342643781396143 1.04836476940397 0.29447057884076 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.543516618463356 0.362039032274804 1.50126525045731 0.133286969043145 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -0.666751208145236 0.405021634541343 -1.6462113410319 0.0997202551488229 1 FALSE