Group12 Weeks.A.Plaque 2...1 Group12 Weeks.A.Plaque 2...2 Group12 Weeks.A.Plaque 2...3 Group12 Weeks.A.Plaque 2...4 Group12 Weeks.A.Plaque 2...5 Group12 Weeks.A.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.739996679143226 0.326564234576032 -2.26600650283685 0.0234509851015561 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.450237747295752 0.648103284120754 -0.694700610731459 0.487242945231205 1 FALSE TannerellaTannerella forsythia (SP101) 0.265608611711974 0.369153416817055 0.71950739072694 0.471828350111011 1 FALSE PrevotellaPrevotella oralis (SP104) -0.121964012926939 0.377376841829875 -0.323188917304899 0.746552173639202 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.13676222149827 0.4552882561669 -0.300386007426766 0.76388273561849 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.02049045527519 0.502666838307239 -2.03015273239777 0.0423410167792024 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.280008444381287 0.417827554148309 -0.670153132796734 0.502760176979719 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.250043743014504 0.434817428139336 -0.575054555849996 0.565254400910812 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) 0.140616936609038 0.53126998284899 0.264680748298567 0.791255409353595 1 FALSE PrevotellaPrevotella salivae (SP111) 0.342760261635063 0.373759307849538 0.917061473618325 0.359110427960421 1 FALSE CatonellaCatonella morbi (SP118) -0.0483910234765968 0.389591291619008 -0.124209715457192 0.901149229989105 1 FALSE PrevotellaPrevotella oris (SP12) 0.473661218159709 0.534919309183629 0.885481623167782 0.375896926718356 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.588975061742792 0.407629146989031 -1.44487965616119 0.148491691561731 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.124769332514786 0.411685662713624 -0.303069413912472 0.761836962782335 1 FALSE CampylobacterCampylobacter showae (SP122) -0.0904061336141948 0.379052472055979 -0.238505590331155 0.811488979988525 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.481822028033078 0.327654009398904 -1.47052077561023 0.14142076311641 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) 0.572443353472363 0.408924523760735 1.39987533202412 0.161550654165696 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0282961727075178 0.484493734276234 0.058403588541322 0.953427156411006 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.0232091874752585 0.40416530009354 -0.057424987919267 0.954206658360703 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.191975442434355 0.45844409608696 -0.418754312844156 0.675395697594564 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.144217181421694 0.355895771322759 0.405223082268388 0.68531353961703 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.282375491876088 0.593504785843897 -0.475776267708746 0.634233779071497 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.788458415182554 0.470265530451462 1.67662387337984 0.0936160553804555 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.386069877606226 0.325997438387308 -1.18427273390887 0.23630511846917 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) -0.0165205333046511 0.336088867395718 -0.049155252992059 0.960795571068348 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.437630481375446 0.577115518536244 0.758306556173402 0.448267483321335 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.380065933611137 0.524677244109744 0.72438044126732 0.468832204099324 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.0166385388835576 0.34152959383562 -0.0487177075833899 0.961144264020432 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.301071268493401 0.439369673495362 0.685234522670303 0.49319594231278 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.139072136169915 0.386907632598093 0.359445315761911 0.719261979599417 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.168689653265031 0.384839022690244 -0.43833822278675 0.661141121881804 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.148732421181613 0.531752683481314 0.279702248436024 0.779705953154693 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.449953071592955 0.594710751268826 -0.756591453295525 0.449294663301082 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.580123939111189 0.408698540803509 -1.41944215893371 0.155770148683293 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.328821196414664 0.47012637371439 -0.699431503526814 0.484282405597863 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.208330159046137 0.466452737170935 0.446626512065665 0.655144749934066 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.112689102009727 0.504680132918411 -0.223288167414239 0.823311235846069 1 FALSE KingellaKingella oralis (SP176) 0.124810417772077 0.495297144615617 0.251990989911597 0.801048028140113 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.280232325398696 0.46918278817804 0.597277505611218 0.550322120197993 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) -0.511181240392362 0.365073471395442 -1.40021469771124 0.161449035841089 1 FALSE GemellaGemella haemolysans (SP183) -0.317424686120201 0.454818351477075 -0.697915299787988 0.485230165579975 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.158315563652267 0.422033984972506 0.375125154109521 0.707567390452687 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 1.0092832493167 0.512614687788054 1.96889256855238 0.0489654291179391 1 FALSE RothiaRothia dentocariosa (SP193) -0.292656100282764 0.623223209996241 -0.46958472596765 0.638651739315067 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.195358983670786 0.400099886613697 -0.488275528704181 0.625354692491049 1 FALSE EikenellaEikenella corrodens (SP200) 0.205900950853895 0.359990612596885 0.571962000254884 0.567347718791517 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.278188732834579 0.563485868313172 -0.493692474786198 0.621523380589366 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.309957956895288 0.455417667973781 -0.680601519643136 0.496123665108777 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.774998766296073 0.471598836898716 1.64334325205835 0.100311934160788 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.507004586891699 0.462371459092658 1.09653088857739 0.272846513448137 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.364251682895994 0.480186827741158 -0.758562421650479 0.448114359170548 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.483243628776898 0.528107563011468 0.915047733876904 0.360166571562531 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.0232717012108914 0.370954847180527 0.0627345926000694 0.949977850723951 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) -0.113090526715538 0.335571460880927 -0.337008774282111 0.736110285712783 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.143856387062293 0.388909896081605 0.369896442625125 0.711459652128964 1 FALSE FilifactorFilifactor alocis (SP234) 0.218958016329369 0.334753009170241 0.654088269055758 0.513054938831861 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) -0.368687580256352 0.555789409975611 -0.663358411727439 0.507101034640623 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) -0.292551117917483 0.361394766465195 -0.8095056848192 0.418224334232245 1 FALSE LautropiaLautropia mirabilis (SP245) -0.446438982829832 0.497831954034759 -0.896766427328731 0.369843566070341 1 FALSE ActinomycesActinomyces oris (SP249) -0.319879451849585 0.481842933657448 -0.663866645135847 0.506775666053213 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.156112986454705 0.319946287666643 0.487934983066163 0.625595894410376 1 FALSE ArachniaArachnia propionica (SP260) -0.181246519266221 0.429767844495361 -0.421731224398705 0.673221210706818 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.324670818897022 0.502449748997467 0.646175701241435 0.518165574023755 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.126110895062819 0.423800451473447 0.297571403296914 0.76603030318344 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.0444287135885227 0.489241462856692 -0.0908114233186665 0.927642433063202 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) -0.187438519662847 0.36210561441799 -0.517634944611713 0.60471299579154 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.0933284443766371 0.347423480097694 -0.268630215638832 0.788214257965299 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.372015689265056 0.379724521593654 0.979698881978322 0.327234778157508 1 FALSE DialisterDialister invisus (SP28) 0.545832742166257 0.506505154576731 1.0776449898568 0.281192216474378 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.45453316907874 0.516395170981655 -0.880204143301115 0.378748729356429 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.530574785506412 0.380895920560362 1.39296526128672 0.16363029580407 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.0638702254413415 0.476501209908404 0.134040006852489 0.893370938972723 1 FALSE ActinomycesActinomyces israelii (SP293) 0.489036713948708 0.428778560216955 1.14053443740579 0.254063713999808 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.0354158686504808 0.39210972705637 -0.0903213213208285 0.928031877433533 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.488585345306934 0.437443329295891 1.11691118045705 0.264032303697491 1 FALSE ParvimonasParvimonas micra (SP31) 0.300523552519829 0.519997206586326 0.577933013318867 0.563309345579572 1 FALSE ActinomycesActinomyces massiliensis (SP310) 0.0580020421844027 0.311642276986708 0.186117373885305 0.852352717563595 1 FALSE TreponemaTreponema denticola (SP311) -0.35857634935282 0.331769790495412 -1.08079867313229 0.279786678824719 1 FALSE RothiaRothia mucilaginosa (SP318) -0.701047650988555 0.431248403215572 -1.62562376060119 0.104029717426824 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.251326537010308 0.38625309012795 0.650678385322569 0.515254118826458 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.210728284817285 0.365198845048943 0.577023415254896 0.563923637892401 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.00840407689373404 0.355441967042368 -0.0236440197640823 0.981136559259911 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) -0.176457533509093 0.38942014283187 -0.453128932227003 0.650455902981693 1 FALSE GemellaGemella morbillorum (SP332) -0.528834673455319 0.407454109729504 -1.29789996180526 0.194321713205023 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) -0.13244583967105 0.402542823815671 -0.329022980500824 0.742138318279463 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.365075190434202 0.420640959986284 0.867902142592358 0.385447905927666 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.222712543408025 0.38430301913292 -0.579523272834333 0.562236147912599 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.617390993612023 0.659006654841398 -0.936850924154338 0.348835246221885 1 FALSE NeisseriaNeisseria elongata (SP369) -0.0711524800057175 0.29303402924559 -0.242813028196411 0.808150242520261 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.411375678706925 0.451176073292329 -0.911785227671822 0.361881788239328 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.190668913985441 0.379810585876319 -0.502010531237616 0.615660113057889 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.0192569013193546 0.364061004710748 -0.0528947101452256 0.957815799190491 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.775978839202526 0.541383261407636 1.43332624873721 0.151764624017904 1 FALSE NeisseriaNeisseria mucosa (SP44) -0.671735459650218 0.32605061492164 -2.06021834926352 0.0393776715088293 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) -0.623501364771452 0.406537656582998 -1.53368662084606 0.125106766779402 1 FALSE GemellaGemella moribillum (SP45) 0.282262664427809 0.319931493468355 0.882259703062736 0.377636382623134 1 FALSE RothiaRothia aeria (SP465) -0.124197663448494 0.457087438575139 -0.271715328331162 0.785840914271358 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.0577649652749386 0.505649980212922 0.11423903398674 0.909048309791247 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.532226179302751 0.614864490452248 -0.865599148377045 0.386710022789952 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.260855591877984 0.567110323688584 0.459973273244849 0.645535404564489 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.264302292604551 0.597695224492713 -0.442202449967498 0.658342713361329 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.34021614160946 0.348753541031469 0.975520250212344 0.329302261823502 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.106176967156246 0.386221984575962 -0.274911764209433 0.78338402873134 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.211305068884399 0.596609822558535 0.354176315733836 0.723206751983442 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.349479976989812 0.558067188768274 0.626232797812678 0.531162257683658 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) -0.0612739156673788 0.326727957048278 -0.187538024664124 0.851238813149991 1 FALSE PrevotellaPrevotella denticola (SP60) 0.975869409453794 0.53353660370868 1.82905803026522 0.0673909154042583 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.565908483450843 0.483541251782946 -1.17034168514927 0.241863492967249 1 FALSE TreponemaTreponema socranskii (SP63) 0.556258711331316 0.459935246904643 1.20942831643134 0.226498335361366 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.686265193869946 0.607605416825992 1.1294586500806 0.25870440346612 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.495338025423646 0.345165623596939 -1.43507345911732 0.151266165736413 1 FALSE CampylobacterCampylobacter concisus (SP67) -1.02852815710857 0.344125490919007 -2.98881711541284 0.00280059709378856 0.389282996036609 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.00499700371105638 0.421535108933724 -0.0118543001642173 0.990541858437029 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.275857966800844 0.403795221203302 0.683163029960565 0.494503830849353 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.185713049974681 0.344569451748667 -0.538971313423753 0.589906648679303 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.226893126797057 0.350528320229848 0.647289002635447 0.517444917699203 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.474931600391648 0.414884314151918 -1.1447326018157 0.252319942011637 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) -0.452316450048697 0.284678795602776 -1.58886596766354 0.112090656008131 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.049842876186338 0.37940263861611 -0.131371980880635 0.895481052558498 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.418623271940046 0.451487525142724 -0.927208945159029 0.35381805934961 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.0599461453106206 0.447358657044904 0.134000190600097 0.893402423717456 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.687974980472756 0.569740907555205 1.20752252708148 0.227230974924896 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.166767178332354 0.451330487292269 0.36950124803858 0.711754143084504 1 FALSE VeillonellaVeillonella parvula (SP88) 0.2381037467783 0.414838883637371 0.573966800533667 0.565990267519195 1 FALSE PrevotellaPrevotella oulorum (SP9) -0.377865632491565 0.45671792320205 -0.827350128592172 0.408038638733084 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.0536461825611093 0.346871823580663 0.154657077670173 0.877091669810688 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.128534768774587 0.557711620099234 0.230468156198211 0.817728005183174 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.269715138843885 0.460256559619126 -0.586010417900575 0.557868513981446 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.107587497754294 0.355215092441199 0.30287986080463 0.761981419664294 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.317766466785356 0.382571318487967 -0.830607135007563 0.406195602719706 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.601911979207608 0.489300710643139 1.23014736360479 0.218641926480142 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.135077193881621 0.424387375088774 -0.318287493480138 0.75026687018199 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.246489231589599 0.348581179400218 0.707121457371041 0.47949100255419 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.29854199227231 0.503985218441855 -0.592362595862031 0.553607807786771 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.445404236256924 0.391159942469883 1.13867548257761 0.254838532374291 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.288321629209666 0.532321497134193 -0.541630632544194 0.588072984977582 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.652434385241918 0.447583530423886 1.45768184236812 0.144928259122181 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.529350195875632 0.455961733270174 1.16095311788363 0.245660965540891 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 1.2481915328839 0.500825605798077 2.49226780426868 0.012693029279567 1 FALSE