Group24 Weeks.A.Plaque 2...1 Group24 Weeks.A.Plaque 2...2 Group24 Weeks.A.Plaque 2...3 Group24 Weeks.A.Plaque 2...4 Group24 Weeks.A.Plaque 2...5 Group24 Weeks.A.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.0792351647457164 0.382456600966553 -0.207174263813127 0.835873765777908 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.368397916530646 0.789159951404914 -0.466822873962117 0.640626609113323 1 FALSE TannerellaTannerella forsythia (SP101) 0.353477871938795 0.401304423830814 0.88082226596091 0.37841402627711 1 FALSE PrevotellaPrevotella oralis (SP104) -0.30987785777192 0.39152498160925 -0.791463820516015 0.428673380496068 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.32104884431648 0.346199245167443 0.927352814305534 0.353743381172136 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 1.30265208198829 0.506154912641446 2.57362331067815 0.0100639777251698 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.0395414341161802 0.465869110267837 -0.0848767030152462 0.932359413239767 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.203949099283723 0.455218216913042 -0.448024906970457 0.65413522130371 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.260188583830667 0.55187315349516 -0.471464470019648 0.637309086379921 1 FALSE PrevotellaPrevotella salivae (SP111) -0.196118276672434 0.390444484135412 -0.502294909112911 0.615460089756195 1 FALSE VeillonellaVeillonella atypica (SP116) 0.0944099816167843 0.35309873800184 0.267375584945569 0.789179995746315 1 FALSE CatonellaCatonella morbi (SP118) -0.386008722980001 0.456152186956531 -0.846227934487104 0.397425601267013 1 FALSE PrevotellaPrevotella oris (SP12) 0.19138733479891 0.5072831363646 0.377279119054639 0.70596618818897 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.139653556699669 0.50044255101646 -0.279060116722719 0.780198689952349 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.169753616602545 0.370426605108452 0.458265184685764 0.646761933604795 1 FALSE CampylobacterCampylobacter showae (SP122) 0.680145922339871 0.448553452642591 1.51630963563625 0.12944107631759 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 0.185799292051252 0.414306176580229 0.448458899611101 0.653822042020594 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) 0.260908535064114 0.449793172744686 0.58006335105538 0.561871897171429 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0634402116853987 0.589016717120279 0.107705282110769 0.914229479372901 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.0810089560938053 0.362318900040608 -0.223584682125956 0.823080483841379 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.167791226099029 0.507014831985285 -0.330939482464486 0.740690198031253 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.628312459370035 0.351392873171818 -1.78806261407247 0.0737659064611265 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.55494735013893 0.668314505158266 -0.830368555306922 0.406330438425778 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.279047107170644 0.467060318193736 -0.597454110958953 0.550204235942032 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.121705526707186 0.395999191835616 -0.307337815875411 0.758586254696102 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) -0.241752183269661 0.455358376181303 -0.530905317471104 0.595484392750044 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.0475640288823989 0.598958518307615 -0.0794112236967481 0.93670554161665 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.201377690688167 0.552652172870936 -0.364384147160851 0.715571171718475 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.12051239832526 0.37838705939272 -0.318489745708198 0.750113471766206 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.379967567407855 0.346669995013494 1.09604976742526 0.273056995739197 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.211216782693287 0.485449056670867 0.435095670268222 0.663492986060295 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.150637886053681 0.4561107433272 0.330266033540057 0.741198955641653 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.0668560369791458 0.377269545698956 -0.177210267145427 0.859343231283671 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.215305277898847 0.34711462377891 -0.620271412235236 0.53507911286463 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.692330892340282 0.491127026259867 -1.40967785383888 0.158634826866572 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.276795334819082 0.649248061176521 -0.426332170045287 0.669865819588045 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.28614077643169 0.460133851771175 0.621864214793717 0.534031157443427 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.148846110678963 0.59531497123074 0.250029174255844 0.8025647872073 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.64310175499799 0.527586005639689 -1.21895150387516 0.22286259967995 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.182036602129267 0.520201384283639 -0.349934866820754 0.726387579399447 1 FALSE KingellaKingella oralis (SP176) 0.297197336562403 0.558476758751337 0.532157035911195 0.594617237052255 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.262374513461479 0.569071082998342 -0.461057539734879 0.644757323760271 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) -0.421629912519857 0.397030618899364 -1.06195817765563 0.288254671910205 1 FALSE GemellaGemella haemolysans (SP183) 0.442994394069614 0.469006107739615 0.944538646212169 0.344894462795289 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.299484983665713 0.40875618169333 0.732673894802165 0.463757349581352 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 0.0456830674422385 0.581706419211951 0.0785328576984353 0.937404194260083 1 FALSE RothiaRothia dentocariosa (SP193) 0.201189990417515 0.596116085107683 0.337501361636922 0.73573898586062 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.444321488203002 0.505821108748657 -0.878416263216459 0.379717861803763 1 FALSE EikenellaEikenella corrodens (SP200) 0.983042944810776 0.4060208019001 2.42116399014613 0.015470896254721 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.0583430897167341 0.623375812851052 0.0935921614441502 0.925433136543738 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.332497942998766 0.464742126667171 0.715446102085097 0.474333433932845 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.138187221237173 0.422629712990557 -0.326969962096017 0.743690604384606 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.0826442877578287 0.502302604120643 0.164530876566945 0.869313241955671 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.104739494316312 0.532617627675402 -0.196650446537875 0.844101090697053 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.0157041121982734 0.511998298539433 -0.0306721960660265 0.975530965050987 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.0459026927431451 0.38993418460985 0.117719078128718 0.906290249727919 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.484072806305731 0.398748298825141 1.21398086896417 0.22475502970462 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.939049124712132 0.437786772278759 2.14499200106986 0.0319534865414926 1 FALSE FilifactorFilifactor alocis (SP234) -0.00909154279786369 0.393812798611218 -0.0230859505580444 0.981581712531307 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) -1.10432252628099 0.627435707050384 -1.76005686936831 0.0783981647012757 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.219744926061428 0.434194502893329 0.506097899897672 0.612787924779431 1 FALSE LautropiaLautropia mirabilis (SP245) -0.096118658472364 0.550197127427962 -0.174698582891 0.861316481340896 1 FALSE ActinomycesActinomyces oris (SP249) -0.886095592457125 0.506316683636859 -1.7500817592901 0.0801042067921966 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) 0.248505999534 0.35136448719394 0.707259864303914 0.479405002539549 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.0861288898014087 0.385263247415185 0.223558541800357 0.823100826003392 1 FALSE ActinomycesActinomyces johnsonii (SP26) -0.312015841472938 0.396926533694864 -0.786079576410478 0.43182086865599 1 FALSE ArachniaArachnia propionica (SP260) -0.136902945974244 0.48947098175789 -0.27969573493932 0.779710950812302 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.243361848759507 0.50829658951895 0.478779228068053 0.632095695455165 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.0175814130783277 0.51777476313456 -0.0339557165202327 0.972912463417062 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.147963608342788 0.495260218330472 0.298759324626506 0.765123688460143 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) -0.146380681016481 0.343616828807276 -0.425999743739506 0.670108032739825 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) 0.217439177542683 0.375015881502278 0.579813251299231 0.562040560449834 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.139253647797363 0.39904828454337 0.348964406542207 0.727116031273339 1 FALSE DialisterDialister invisus (SP28) 0.171952258086792 0.525921860913891 0.326954003752557 0.743702674569719 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.564216187312454 0.592716678310815 -0.951915490079367 0.341139843030168 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.0711301054390982 0.416412341164892 -0.170816516244728 0.86436804185981 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.284757880949219 0.47218659772808 0.603062184143573 0.546467322129659 1 FALSE ActinomycesActinomyces israelii (SP293) -0.0584815607245756 0.513754271086801 -0.11383177525875 0.909371149287006 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.448213446333446 0.349813568153694 -1.28129234294457 0.200091001381608 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.48452479650711 0.443465266691159 -1.09258792717254 0.274574765794598 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.264144322555545 0.52742611357849 0.500817679965397 0.616499441667194 1 FALSE ParvimonasParvimonas micra (SP31) -0.14295302268254 0.535447360644546 -0.266978667166199 0.78948558625147 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.193544249502996 0.427190288217847 -0.453063318247296 0.650503148102082 1 FALSE TreponemaTreponema denticola (SP311) -0.136402447054233 0.403784641100988 -0.337809894606957 0.735506452967235 1 FALSE RothiaRothia mucilaginosa (SP318) 0.0941766963349581 0.47829985990105 0.196898858290365 0.843906687142875 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.152462828036553 0.406008054597977 0.375516757142958 0.707276186354727 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.455183764087059 0.460608809817249 0.988222010490111 0.323043930825012 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.338278719416848 0.362842548804497 0.932301684384639 0.351180637488426 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.257811111190628 0.431158857579733 0.597949239957228 0.549873803136998 1 FALSE GemellaGemella morbillorum (SP332) -0.169573852699436 0.431162416391583 -0.39329460605265 0.694101901670459 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 1.02026556894629 0.508165924790824 2.00774101365859 0.0446708198986805 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.136173122470771 0.476448697713132 -0.285808573146232 0.775024741492753 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.0543622632063263 0.382415376750045 0.142155013923142 0.886957564527782 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.679688880534571 0.730091338283715 -0.930964175157002 0.351872095934953 1 FALSE NeisseriaNeisseria elongata (SP369) -0.0792659784819224 0.335919065423234 -0.23596748931786 0.81345789763747 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.0416093569123278 0.346914530437353 0.119941234112827 0.904529700133022 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.129754740928616 0.40430958777927 -0.320929171235618 0.748264066836304 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.00663226749897022 0.370113808630845 -0.0179195354085946 0.985703044513449 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.325310119195415 0.381796757292972 -0.852050503262362 0.394186062118853 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 0.305017510539392 0.568599975283635 0.536436024970349 0.591657239351454 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.175989312845941 0.452029396091255 0.389331566415235 0.697030888125661 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) -0.384474329914372 0.48689604207368 -0.789643572120455 0.429735954207689 1 FALSE GemellaGemella moribillum (SP45) 0.0384334574644415 0.372702286009327 0.103121067155138 0.917866884985261 1 FALSE RothiaRothia aeria (SP465) -0.189447040919742 0.524703273618756 -0.36105557263474 0.718057904070382 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.721156221658914 0.604086845559069 -1.19379560564922 0.232557931041942 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.559199706338996 0.567807166878677 -0.984840873730077 0.324702239917041 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.246220254881925 0.564652009017632 0.436056634794045 0.662795639280985 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.0210375579357365 0.656301794906699 -0.0320547012045384 0.974428428030913 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.0267207754369835 0.446003497494431 0.0599115827277054 0.952226054784977 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.0911637893790644 0.406448415340262 0.224293627280465 0.822528834594287 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.25237353286177 0.622933594380255 -0.40513713682893 0.685376710018263 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.543326076483027 0.556345377719177 -0.976598527178343 0.328767948548533 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.0253682307478308 0.367126197773149 0.0690994837788887 0.944910431932789 1 FALSE PrevotellaPrevotella denticola (SP60) 0.676772226189045 0.554806214312885 1.21983533841129 0.222527302120672 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.172401338239012 0.501336546372035 -0.343883444138691 0.73093394308086 1 FALSE TreponemaTreponema socranskii (SP63) 0.194659172991323 0.500151421374736 0.389200479439358 0.697127848818638 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.453784282840851 0.660882758341364 0.68663356263027 0.492313672970404 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.136159180168797 0.348110496783807 0.391137818097332 0.695695368059393 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.471243467228357 0.460326976353611 1.02371464510122 0.305970076014332 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.721731412896037 0.505105249969195 1.42887331489834 0.153040648522619 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) -0.370379575054395 0.524431110997637 -0.706250196236097 0.480032559348928 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.223483845098803 0.415715143160123 -0.537588896569791 0.590860897489587 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.354895647905622 0.459278757989069 0.772723845229675 0.439685831491187 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.270473622534862 0.447597527174023 -0.60427863451914 0.545658408624806 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) 0.0800476671802124 0.375083625823915 0.213412854278505 0.831004955180163 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.283480535384254 0.405946447212733 -0.698320030463767 0.484977075276823 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.289452987176773 0.465831758166724 -0.621368084297027 0.534357466289234 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.25031554194556 0.537086092447955 -0.466062229994936 0.641170957632017 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.361116178418233 0.607970809625279 0.593969599693127 0.552532446120656 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.0424931772438872 0.478239764184462 0.0888532916461901 0.929198504527573 1 FALSE VeillonellaVeillonella parvula (SP88) -0.391287670145925 0.397886469552922 -0.983415371187636 0.325403048127839 1 FALSE PrevotellaPrevotella oulorum (SP9) -0.283580289985699 0.441525603518412 -0.642273715784352 0.520695477255974 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.03190514630888 0.346234427575846 0.0921489712396982 0.926579680512719 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.661865639591043 0.603964540994327 -1.09586837416215 0.273136381014689 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.293139476920203 0.474273638441213 0.618080899211813 0.536522012524841 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.230196430315953 0.396870489548042 0.580029093566774 0.561894998428243 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.100488668589832 0.396594621429226 0.253378798299626 0.799975509718547 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.132476309421109 0.50107551084397 0.264383923289279 0.791484098292882 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.467179048551098 0.428239658329032 -1.09092896807831 0.275304139368923 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.328737748250309 0.431424247690346 0.761982549683345 0.446070419201952 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.402984150762782 0.549436170220063 -0.733450348930209 0.463283800215735 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.0817025236204061 0.453069900945937 0.180330945511552 0.856892762876381 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.268365659090209 0.508550381786491 0.527707123426915 0.597702628321791 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.570752914629328 0.544478340128076 -1.04825641823524 0.294520483212621 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.039024988031264 0.541393110458971 0.0720825353654392 0.942536224825917 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -0.597995313253084 0.537357278515599 -1.11284491187128 0.265775042770438 1 FALSE