GroupBaseline.B.Plaque 2...1 GroupBaseline.B.Plaque 2...2 GroupBaseline.B.Plaque 2...3 GroupBaseline.B.Plaque 2...4 GroupBaseline.B.Plaque 2...5 GroupBaseline.B.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.00299484896628191 0.270133039152985 0.0110865704383011 0.991154377820981 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.484422850532096 0.549230176756759 -0.882003340371145 0.377775000885585 1 FALSE TannerellaTannerella forsythia (SP101) 0.281894395255632 0.368389234275161 0.765208016489094 0.444147686850338 1 FALSE PrevotellaPrevotella oralis (SP104) 0.135684898380989 0.343702819471212 0.394773888063358 0.693009767301152 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.212494411745822 0.356926953659167 0.59534425620525 0.551613378835764 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.0858639411645358 0.451181278148477 -0.190309184629508 0.849066856882453 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 0.476801774668089 0.437731920054428 1.08925521037808 0.276041358211714 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -1.02725994353829 0.340677575140432 -3.01534359317557 0.00256688289594013 0.346529190951918 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) 0.225796972006396 0.465839812395944 0.484709477373905 0.627882442743434 1 FALSE PrevotellaPrevotella salivae (SP111) 0.740989248180944 0.328345891307089 2.25673373049132 0.0240247178332329 1 FALSE VeillonellaVeillonella atypica (SP116) 0.243172998767549 0.325805657094394 0.746374390599041 0.455441284911324 1 FALSE CatonellaCatonella morbi (SP118) 0.420145083625378 0.358376351061723 1.17235716692985 0.241053688747653 1 FALSE PrevotellaPrevotella oris (SP12) 1.13220722103903 0.472854925421963 2.39440716416072 0.0166472571328614 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.488932554811851 0.396528357505031 1.23303301153095 0.217563448153496 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.610982693554293 0.352798501448353 -1.73181771194041 0.0833060235479981 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.35438061473031 0.360876498379375 -0.981999704391289 0.326099993843806 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) 0.564596457233495 0.394167452301863 1.4323771634019 0.15203591050134 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.228153494334134 0.416132424086827 -0.548271370188949 0.583505582731362 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.369655569629498 0.346704788920455 1.06619689557939 0.286334645211637 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.440487343660181 0.426382857455663 1.03307939322112 0.301566745969926 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.138138043251207 0.331619997009091 0.416555227359887 0.677003763751822 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.582877234087623 0.469814236274039 -1.24065468664861 0.214733340493373 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.345234047477337 0.393914899867905 0.876417844547407 0.380802920917465 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.297684648041315 0.375888472265869 0.791949394582019 0.428390184053638 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.248118501697761 0.299594926434107 0.828179918301562 0.407568614864417 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.339501581842146 0.500038580197082 0.678950775574831 0.497169051863966 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.058370815945862 0.472404041218935 -0.123561212125216 0.901662705310057 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) 0.299226924980324 0.407756320336237 0.733837613439273 0.463047713342452 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) 0.58360783174327 0.342550793500117 1.70371180805065 0.0884349410386409 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.846209437975399 0.448876908362274 1.88517034895556 0.059406842637148 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.156156195616073 0.358918132281299 -0.435074691332917 0.663508213178698 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.105484326666876 0.472401064076911 0.223294007334629 0.823306690988645 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.27655834619286 0.579027101555625 -0.477625909823311 0.632916486244545 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.242056228020279 0.360938072687485 -0.670630909668156 0.502455686525273 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.511820699218519 0.385594472245703 -1.32735486646806 0.184391322181827 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.425485446880485 0.326081055297036 -1.30484565100815 0.19194541082093 1 FALSE StreptococcusStreptococcus anginosus (SP175) 0.441278424820142 0.514288070577027 0.858037450343795 0.390871784266046 1 FALSE KingellaKingella oralis (SP176) -0.17857698023704 0.415252324156184 -0.430044505108836 0.66716326727396 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.0345294030801108 0.406869850975557 -0.084865966346042 0.932367949064548 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) -0.921357505594616 0.263699257244036 -3.49397080304235 0.000475893060903795 0.0651973493438199 FALSE GemellaGemella haemolysans (SP183) -0.235983723757757 0.380517457807061 -0.620165301002855 0.535148963637345 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.149310489795615 0.353299659665461 0.422617134522565 0.672574623159302 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.452331641834079 0.496484968562171 -0.911068150046997 0.362259466789418 1 FALSE RothiaRothia dentocariosa (SP193) -0.634825336270401 0.548629771393597 -1.15711062244736 0.247227167304359 1 FALSE StreptococcusStreptococcus vestibularis (SP198) -0.136822652729075 0.379705017611428 -0.360339332858363 0.718593388758927 1 FALSE EikenellaEikenella corrodens (SP200) -0.284611298062583 0.283423447736079 -1.00419107994061 0.315286520803319 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.287665939865192 0.540867479091157 -0.531860300324526 0.594822755026277 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.47156828432962 0.393565745696328 -1.19819442999361 0.230841333319015 1 FALSE PrevotellaPrevotella multiformis (SP204) 0.188489016915255 0.293874481610362 0.641392937155958 0.521267420601459 1 FALSE CampylobacterCampylobacter gracilis (SP205) 1.26558521864184 0.430178284275821 2.94200164188292 0.00326098198010656 0.436971585334279 FALSE SelenomonasSelenomonas sputigena (SP21) 0.872784672482465 0.447942907999545 1.94842837534857 0.0513637273161136 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.990563279585299 0.515439667656807 1.92178317219629 0.0546330466110498 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.231217339279514 0.442533108830396 0.522485966961016 0.601332014569983 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.410853922004124 0.316822381006606 1.29679576518162 0.194701468184805 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.12165987216477 0.431388434413292 0.282019318228208 0.7779286974809 1 FALSE FilifactorFilifactor alocis (SP234) 0.585517799209452 0.369980193749547 1.58256525376548 0.113520588304005 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) -1.42450706286891 0.503057397625483 -2.83169886695401 0.00463014313711463 0.615809037236246 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.0384338152331182 0.305983384013665 0.12560752394124 0.900042606887804 1 FALSE LautropiaLautropia mirabilis (SP245) -0.0870814159899689 0.360411835133031 -0.241616416280632 0.809077400567515 1 FALSE ActinomycesActinomyces oris (SP249) -0.502690338894483 0.454149798545293 -1.10688222367305 0.268344852447546 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) -0.21486205712544 0.301101143914226 -0.713587648098231 0.475482197662868 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.162880800916594 0.265169983523036 -0.614250522448156 0.539049792270572 1 FALSE ArachniaArachnia propionica (SP260) -0.111273504109326 0.35159135263569 -0.316485326715715 0.751634160837416 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -1.07530732788494 0.403939375909447 -2.66205126812395 0.00776660480667089 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.0683445007145913 0.319190078797065 -0.21411849946014 0.830454649844011 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.95571824132129 0.459260635059344 2.08099316240722 0.0374345319172655 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) -0.572913581723786 0.298777383750808 -1.917526603023 0.0551710645950146 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.148891579676199 0.297349940884082 -0.500728465704463 0.616562235867325 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.11783911643859 0.328870143506084 0.358315033351179 0.720107569010933 1 FALSE DialisterDialister invisus (SP28) 1.14898002063838 0.4507518348653 2.54903015754053 0.0108022958551389 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.965587221797266 0.394939092786697 -2.44490160491347 0.0144891665328802 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.691687544577663 0.386726465589139 1.78857049135219 0.073684013710854 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.978695870803148 0.440787368066552 2.2203355670015 0.0263959972972067 1 FALSE ActinomycesActinomyces israelii (SP293) -0.84223298824857 0.408477233450008 -2.06188477417713 0.0392187074560483 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.180541294230813 0.335023309747067 -0.538891739703475 0.58996155722211 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.842342255869253 0.377069359797359 2.23391859874782 0.0254884295687429 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.0764362903437185 0.370288022849597 0.206423879863825 0.836459819056639 1 FALSE ParvimonasParvimonas micra (SP31) 0.43558065663681 0.4477781571434 0.972759947505246 0.330672623243472 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.373473752323056 0.35329371118796 -1.05711972926786 0.290456948102378 1 FALSE TreponemaTreponema denticola (SP311) 0.740673074769531 0.345018240124607 2.14676497828645 0.0318119967840279 1 FALSE RothiaRothia mucilaginosa (SP318) -0.376709885157757 0.395872874648217 -0.951593072630984 0.341303396123972 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.317587714840115 0.318070929511247 -0.998480795865645 0.318046272176748 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.357797345761272 0.300562746300853 1.19042479537078 0.233879472247954 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.619567604829259 0.395688849795253 1.56579495517716 0.1173966276582 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.271307643192003 0.34145920064388 0.794553617768701 0.426873207876356 1 FALSE GemellaGemella morbillorum (SP332) 0.887389707434112 0.373751372924263 2.37427812101692 0.0175833004974317 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.34130020034067 0.372517635624416 0.916198772089219 0.359562649426883 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.0339107601753317 0.353053535784014 -0.0960499095414162 0.923480933684012 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.351431128081986 0.623134644300049 -0.563973021395302 0.57277249284008 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.359889637578302 0.352145583496342 -1.02199105837158 0.306785132469863 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.145037744496181 0.265869977945254 0.545521331957406 0.585395013174925 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.757932624686469 0.437181882218721 1.73367803084593 0.0829752266619252 1 FALSE OlsenellaOlsenella uli (SP417) -0.396182963272859 0.317106763198918 -1.24936775007961 0.211530598346928 1 FALSE AlloprevotellaAlloprevotella rava (SP42) 0.450213298941546 0.346887938474011 1.29786380270837 0.194334140416188 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.418995247287865 0.421475894411487 -0.994114379596759 0.320167185474443 1 FALSE NeisseriaNeisseria mucosa (SP44) -0.576172408764163 0.305406149158181 -1.88657762901081 0.0592171580568991 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.153375879407196 0.348669198139291 0.439889385772251 0.660017223811372 1 FALSE GemellaGemella moribillum (SP45) 0.313598306517713 0.351969463444649 0.89098157393711 0.372939055471673 1 FALSE RothiaRothia aeria (SP465) -0.708242002225771 0.336481383762671 -2.10484750837007 0.0353045841743922 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.658023998269218 0.487400641878544 1.35006797638398 0.176994179317986 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.458987449331505 0.530565234596903 -0.865091452289031 0.386988595866101 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.539625332952392 0.457619187519657 1.17920171983438 0.238317861427784 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.676387597694062 0.512510869578322 1.31975268788069 0.186917602572487 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.368825637544779 0.34029162811339 1.08385163510952 0.27843058672989 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.814677663545767 0.305423568849691 2.66736999575399 0.00764474590293491 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.236117830911366 0.553825569540966 0.426339706754728 0.669860328572858 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.859172895620382 0.498029740638178 1.72514375249846 0.0845015693494012 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) -0.0757303051208551 0.305794189484714 -0.247651223355376 0.804404274439651 1 FALSE PrevotellaPrevotella denticola (SP60) 0.771237494984572 0.470938951382142 1.63765917582543 0.10149281121611 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.406281090955468 0.48362491143762 -0.840074779745649 0.400866459760029 1 FALSE TreponemaTreponema socranskii (SP63) 0.000258677625085163 0.436143835090704 0.000593101642790311 0.999526773383975 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.32650125495081 0.495985128421872 -0.658288396649458 0.510352832561558 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.102278670750135 0.303704260950503 0.33677061503857 0.736289826220557 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.624187286020748 0.351637170819018 -1.77508903443546 0.0758831872925499 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) -0.134364261955419 0.365365783196769 -0.367752723804069 0.713057623262471 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.647969504940369 0.330690845927791 1.95944191658048 0.0500610558257917 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) 0.484186048726203 0.329188318933465 1.47084820717489 0.14133217202658 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -1.25229657893464 0.405886987583591 -3.0853331524375 0.00203324265537531 0.276521001131043 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) -0.412370154980981 0.351352267690216 -1.17366584166909 0.240528897303586 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.174125278187659 0.368981696052051 0.471907631328941 0.636992720747639 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.518891140827377 0.374097680059835 1.38704720313792 0.165427369692272 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.5693678576677 0.396488003180435 -1.43602795822448 0.15099438585564 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 0.0773662729183803 0.515267161153752 0.150147882013569 0.880647943758434 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.0702012029433385 0.414355371179808 0.169422693239024 0.865464174895865 1 FALSE VeillonellaVeillonella parvula (SP88) 1.1590421127078 0.314086948859938 3.69019507787525 0.000224082145097016 0.0309233360233882 TRUE PrevotellaPrevotella oulorum (SP9) 0.586918360641936 0.363370452391345 1.61520662117522 0.106265957180931 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.0136181113112707 0.298641215991506 0.0456002406300743 0.963628877378257 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.35325096037554 0.478832514357409 0.737733862642142 0.460676190309653 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.183556493095387 0.391335139858355 -0.469051905642375 0.639032535035271 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.449205557521001 0.318414502030845 1.41075721946071 0.15831621274977 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.786410508583918 0.441773782676524 1.78012036798423 0.0750562639183234 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.253293879243938 0.353032027000818 -0.717481304446496 0.473077168096546 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.1230648312748 0.379808737058535 0.324017904979983 0.74592447867311 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.0721875818168217 0.403718534474322 0.178806707278913 0.858089478516211 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.0686654695919132 0.40990209448213 0.167516757089678 0.866963463573911 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.88049275759262 0.404169821235287 2.17852177805241 0.0293672126695999 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.502787326859847 0.405938261505529 1.23858077579366 0.215500791075617 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -0.300759773980451 0.481327761518277 -0.624854409044991 0.532066616982273 1 FALSE