Group24 Weeks.B.Plaque 2...1 Group24 Weeks.B.Plaque 2...2 Group24 Weeks.B.Plaque 2...3 Group24 Weeks.B.Plaque 2...4 Group24 Weeks.B.Plaque 2...5 Group24 Weeks.B.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.0364517666892957 0.317434318566499 0.114832469450399 0.908577912384722 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.447090168155328 0.661985196916043 -0.675377894004526 0.499435706518359 1 FALSE TannerellaTannerella forsythia (SP101) 0.191712998057275 0.458447400069087 0.418178831482922 0.675816371659176 1 FALSE PrevotellaPrevotella oralis (SP104) 0.135143155826524 0.371956318709772 0.363330716615604 0.716357850331522 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.112036409519999 0.380171944874344 -0.294699309169248 0.76822359095606 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.167881603532331 0.481062512949367 -0.348980847630505 0.727103688122939 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 0.0911109430902192 0.457355602846042 0.199212478262543 0.84209653880842 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.453420207214022 0.490962864760518 -0.923532592297366 0.355729723655869 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.14084892504186 0.49966139389764 -0.281888748584634 0.778028817169858 1 FALSE PrevotellaPrevotella salivae (SP111) -0.0723767524330078 0.34937060888736 -0.20716325469823 0.835882363289028 1 FALSE VeillonellaVeillonella atypica (SP116) -0.662274674052797 0.363811761368248 -1.82037730600591 0.0687015659880086 1 FALSE CatonellaCatonella morbi (SP118) -0.108089108175403 0.414669636136844 -0.26066318523436 0.794352258703857 1 FALSE PrevotellaPrevotella oris (SP12) -0.726989468506152 0.502291717503048 -1.44734512470184 0.147800286708691 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.105742651706334 0.464023507404655 0.227882100839603 0.819737898110636 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.287175832394646 0.328923396955009 -0.873078154528261 0.38262048011531 1 FALSE CampylobacterCampylobacter showae (SP122) -0.140617472246169 0.418342544278843 -0.336129982879392 0.736772849412005 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.792552205687178 0.369392074927266 -2.14555822791605 0.0319082411498287 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.171067747111693 0.416416380172042 -0.410809361151972 0.681212328449951 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.714146130485168 0.472007275899056 1.51299813996489 0.130280131326813 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.0623793082519018 0.361997232730331 0.17231984836296 0.863186081015321 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.469268139365926 0.437140795960563 1.07349426935724 0.283049408492604 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.507022976437729 0.32988739693438 1.53695770480915 0.124303667070477 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.0816874662657524 0.662821320862229 -0.123242061917214 0.901915418832449 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.264050875409472 0.462390834619345 -0.571055599808434 0.56796195445565 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.234370970284881 0.408255507079524 0.574079139707056 0.565914248763839 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.366997832895664 0.376235191740126 0.975447913838844 0.32933812643812 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.213112771085749 0.590207290050741 0.361081224644695 0.718038728341042 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.312725539444993 0.54662018444038 -0.572107559045146 0.567249108383504 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) -0.0647590368805719 0.358765712362222 -0.180505089112833 0.856756059482696 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.0129912421570545 0.482246088551432 -0.0269390306432085 0.97850836285247 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.0499331510200616 0.444764439620963 -0.112268757508167 0.910610313057655 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.0299556356552301 0.329615438004086 -0.0908805601965124 0.927587496977765 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.586685483438189 0.512524760861698 -1.14469685806361 0.252334753427537 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.437413973826545 0.678904044250899 -0.644294252671873 0.519384641825075 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.731796453423671 0.460366304713166 1.58959603674648 0.111925891001606 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.898017002403165 0.525624747701685 -1.7084754976431 0.0875481490450059 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.028282761941192 0.432945783671854 -0.065326336478723 0.947914173648292 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.10940988380418 0.507394842002237 -0.215630658310273 0.829275656063869 1 FALSE KingellaKingella oralis (SP176) 0.103541705780198 0.513644441722053 0.201582451536051 0.84024316524019 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.18252611581473 0.487703061730584 -0.374256653560975 0.708213377983154 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.493848986023744 0.375760621927479 1.31426487291437 0.18875708396322 1 FALSE GemellaGemella haemolysans (SP183) 0.141581610433021 0.347484434567465 0.407447345401978 0.683679459531641 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.354818902105436 0.323545389760534 -1.09665880996805 0.272790568706028 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.496570554451576 0.555771594966842 -0.893479549780161 0.371600418852385 1 FALSE RothiaRothia dentocariosa (SP193) 0.0845395867099836 0.565307476545684 0.149546203115097 0.881122654415917 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.250453984929348 0.440912513485297 0.568035556418155 0.570010824629994 1 FALSE EikenellaEikenella corrodens (SP200) -0.378421721102072 0.405334894236493 -0.933602624602268 0.350508910961783 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.221734056680047 0.628869022231471 -0.352591793905269 0.724394490493189 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.196030910714449 0.483127863930229 0.405753684169122 0.684923592845317 1 FALSE PrevotellaPrevotella multiformis (SP204) 0.323175857498958 0.347826098715971 0.929130558897072 0.352821429255342 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.0431380031336862 0.39928579161365 -0.108037911790827 0.913965618939669 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.0680427970465526 0.443076294311489 0.153569030706747 0.8779495571407 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.608149382292052 0.489015228816289 1.24362053869803 0.21363925343135 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.621376048310212 0.486238203301734 -1.27792518993951 0.201275805230568 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.459394475674161 0.35431781339877 1.29656048412427 0.194782456295122 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.433783690980795 0.387713881396508 1.11882424590615 0.263215125849804 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.105176094827377 0.468074180573065 -0.224699629231012 0.822212953064778 1 FALSE FilifactorFilifactor alocis (SP234) 0.174514136462491 0.378359366213796 0.461239107700271 0.64462706671017 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) -0.136344703369345 0.562929519391701 -0.242205637957446 0.808620826638048 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.0809970067407367 0.382799287311908 0.211591320635714 0.83242588115477 1 FALSE LautropiaLautropia mirabilis (SP245) -0.0979846899103676 0.547005436568228 -0.179129279820505 0.857836191849343 1 FALSE ActinomycesActinomyces oris (SP249) 0.148011600347182 0.54795992981739 0.27011391215505 0.787072619446336 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.131322151989523 0.339265186919436 0.387078182650987 0.698698328827537 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.271837754909208 0.417989002620203 0.650346667508397 0.515468318797193 1 FALSE ArachniaArachnia propionica (SP260) -0.240042002914619 0.38197701242769 -0.62842002294591 0.529728823643894 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.514370598954107 0.515151706278287 0.998483733403848 0.318044848422647 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.125405357677397 0.401033709691607 -0.312705278002274 0.754504585272087 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.0155490529358191 0.476543565779035 0.032628817284313 0.973970589190947 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) 0.395095588711041 0.313501847824771 1.26026558201301 0.207573571598753 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.371042141036484 0.320206917896859 -1.15875741684007 0.246555079513018 1 FALSE SolobacteriumSolobacterium moorei (SP279) 0.0816304023435235 0.37745675502401 0.216264250823465 0.828781773381466 1 FALSE DialisterDialister invisus (SP28) 0.00202247441544231 0.505268881760965 0.00400276860192454 0.996806261260491 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.319025893039604 0.526128421198578 -0.606365062569379 0.544272363026751 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.11649389780956 0.396963911758665 0.29346218726397 0.769168897975037 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.0477033204135993 0.449425245939132 0.106142947786382 0.915468936184214 1 FALSE ActinomycesActinomyces israelii (SP293) -0.554144265038768 0.503713844633568 -1.10011720134849 0.271281060046599 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.247957218732598 0.374556177485412 0.662002747884876 0.507969460627908 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.640913556895717 0.400893647543063 1.59871217921175 0.109884570172192 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) 0.0158065675814737 0.499054256018668 0.031673044345067 0.974732791594403 1 FALSE ParvimonasParvimonas micra (SP31) -0.0386775431018521 0.488340719035614 -0.0792019620609015 0.936871983998225 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.700607483704614 0.431206887139798 -1.62475949387487 0.104213815057428 1 FALSE TreponemaTreponema denticola (SP311) -0.194242950008242 0.341174787166411 -0.569335593704052 0.569128416057767 1 FALSE RothiaRothia mucilaginosa (SP318) 0.372036059159863 0.486951912989417 0.764009852381355 0.444861371334151 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.119912493224973 0.358160396533703 -0.334801095781367 0.737775133858949 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.197464908524578 0.420015285666482 0.470137433715634 0.638256831129046 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.297117949193224 0.402061696890014 -0.738985960342556 0.459915522668928 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.361425816903187 0.419882341086906 0.860778798097585 0.389359884347813 1 FALSE GemellaGemella morbillorum (SP332) 0.156808318099093 0.368101492101094 0.425992074099031 0.670113621414274 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.351821095904979 0.475752340023066 0.73950470929459 0.459600581183472 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.642615421693127 0.507683634503467 1.26577927279777 0.205592117817826 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.23876600158172 0.357808851629662 -0.667300432882657 0.504580249941142 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.491372778098737 0.708155904015458 -0.693876553612708 0.48775962855556 1 FALSE NeisseriaNeisseria elongata (SP369) -0.175158828884053 0.424327333779816 -0.412791764611947 0.679759185682445 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.467996060194109 0.364148952239012 -1.28517755527396 0.198730244980052 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.625488221902617 0.365133103294764 -1.71304167236153 0.0867048733502837 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.250131654564817 0.452101192139614 0.553264753364272 0.580082132556086 1 FALSE OlsenellaOlsenella uli (SP417) -0.175417275786819 0.340297335217335 -0.515482366838949 0.606215988367737 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.0347204333258229 0.379179210997338 -0.0915673441972183 0.927041797969694 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.301669837798147 0.469766242083264 -0.642170106690377 0.520762740185533 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.134210210487258 0.474613608246648 0.282777838973195 0.777347143210945 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.173704690975805 0.462595018529019 0.375500565328522 0.707288226073752 1 FALSE GemellaGemella moribillum (SP45) 0.0564400188556936 0.393875141943669 0.143294188552182 0.886057845333723 1 FALSE RothiaRothia aeria (SP465) 0.00468278112995017 0.51542134725617 0.00908534571739959 0.992751042648394 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.390696942202369 0.549007383266459 0.711642418864785 0.476686232528609 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.349005101702365 0.598779446751546 -0.582860857358684 0.559986972691126 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.599423812499469 0.541974165738263 -1.10600071072198 0.268726211752468 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.10995644358417 0.555904042450299 -0.19779752473018 0.843203482891856 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.0738142858748143 0.41835645878049 0.176438738605789 0.859949273007221 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.494531068299762 0.344526718879598 1.43539249991402 0.151175282025879 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.344889752880196 0.615058501460362 -0.560743005846287 0.574972745135532 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.456680191709348 0.513339161566477 0.889626636541362 0.373666398684961 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) -0.185537438806548 0.384072665596897 -0.483078998913394 0.629039645008481 1 FALSE PrevotellaPrevotella denticola (SP60) -0.841097802137854 0.522950271907975 -1.60837052262947 0.107754053610695 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.058893838536773 0.55217289024128 0.106658330348378 0.915060041530642 1 FALSE TreponemaTreponema socranskii (SP63) -0.511447038354108 0.432144706513017 -1.18350874289537 0.236607583612918 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.366340675443518 0.575708845526148 -0.636329766843715 0.524561507237733 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.145041256335488 0.308444505207066 0.470234528049441 0.638187468083683 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.317021648135963 0.417327130706655 0.759647827351061 0.447465122418579 1 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.0097371099855605 0.457509477279532 -0.0212828596326787 0.983020016774884 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.313326650451687 0.546825018573124 0.572992529254195 0.566649752332082 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.149033111245504 0.33649223893639 0.442902076186302 0.657836565624106 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.267329056895765 0.329528668047374 -0.811246737589863 0.41722399040012 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.607716539457279 0.438286757310233 -1.38657289849877 0.165572037106277 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) -0.332017551924335 0.435532242513512 -0.762325999122864 0.445865460401601 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.515985986585609 0.455463312341293 1.13288155731622 0.257263995849054 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.406367815062163 0.430594646521293 -0.943736338445322 0.345304399646202 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.103924197390947 0.496673882131687 0.209240310653969 0.834260645470211 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.0611241836538665 0.536427168376233 -0.113946845456932 0.909279930067013 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.466085453153076 0.477940815920662 -0.975194914573788 0.329463584219738 1 FALSE VeillonellaVeillonella parvula (SP88) 0.0682583055652362 0.379742363742743 0.179748987951942 0.857349632911012 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.647332991093429 0.393455885028642 1.64524922799492 0.0999184254116385 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.105122729442588 0.311770439970301 0.337179911772913 0.735981279621637 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.209194681305058 0.578615051169092 -0.36154379476023 0.717692972307361 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.0613535810246657 0.436856477359223 0.140443335979691 0.888309719968794 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.492067086891065 0.336975619512299 1.46024536612835 0.144222651281317 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.290849681441265 0.295473440992364 0.984351353084156 0.324942788128387 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.209663423109145 0.460301179160854 -0.455491822748249 0.648755449159084 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.136303587035797 0.504222677101851 -0.270324190532717 0.786910856537326 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.0142097060242195 0.404516315838686 -0.0351276461982959 0.971977956533406 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.165058427155706 0.356721799777732 0.462709111858461 0.643572886126744 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.107412125623223 0.433884591913258 0.247559207275783 0.804475476219476 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.492970574804944 0.502694577408774 -0.980656241302714 0.326762289656451 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.159468920104573 0.495004704522605 0.322156372752798 0.747334233482264 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.118618831267178 0.448659580005649 0.264384929138669 0.791483323305527 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.454131063638326 0.522700133579999 0.868817577160273 0.384946917448179 1 FALSE