Group12 Weeks.B.Plaque 2...1 Group12 Weeks.B.Plaque 2...2 Group12 Weeks.B.Plaque 2...3 Group12 Weeks.B.Plaque 2...4 Group12 Weeks.B.Plaque 2...5 Group12 Weeks.B.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.581382748976243 0.327566012853293 1.7748567499786 0.0759215431401484 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.918089376708932 0.592995801427973 -1.5482223895989 0.121568762600145 1 FALSE TannerellaTannerella forsythia (SP101) 0.0565839935497337 0.416821322482615 0.135751197210152 0.892017972782976 1 FALSE PrevotellaPrevotella oralis (SP104) -0.417350831036422 0.339152121696844 -1.23057119309275 0.218483284828155 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.2819808510556 0.44164630349957 -0.638476647084343 0.523163451032986 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.24165994739185 0.469601351537798 -0.514606584074958 0.606827963281995 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 0.364523864387211 0.442143700223208 0.824446586490292 0.409685853585255 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 0.0305450988545188 0.426918433283005 0.0715478566236338 0.942961738042251 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.241703492308676 0.533414288803997 -0.453125267511327 0.650458541710576 1 FALSE PrevotellaPrevotella salivae (SP111) -0.18853081527523 0.413434344643937 -0.456011499087234 0.64838170928074 1 FALSE CatonellaCatonella morbi (SP118) 0.372319253570958 0.402893731139015 0.924112798971528 0.355427590197875 1 FALSE PrevotellaPrevotella oris (SP12) -0.457967117427951 0.541363511954445 -0.845951208966015 0.397579963342307 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 1.00395010235691 0.42410495722293 2.36722086186129 0.0179222339197135 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.253030959301836 0.365668815457658 -0.691967563559257 0.488957699135978 1 FALSE CampylobacterCampylobacter showae (SP122) 0.428556748917774 0.402902133055065 1.06367455954671 0.287476153103102 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 0.660931863051069 0.360092624288688 1.83544959954858 0.0664391003549535 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.175516500233744 0.447301492831932 -0.392389703692967 0.694770292573921 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.164470244392661 0.491104724918176 -0.334898517663547 0.737701640334549 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.188861501537777 0.435648209156244 0.43351837002512 0.664638223456 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.190582844754465 0.472703765741496 0.403176066210328 0.686818705336444 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.229684573606827 0.36696754017971 -0.62589888330272 0.531381267034799 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.636900069044529 0.579605396394399 1.09885117186028 0.271832987613267 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -1.03027989172444 0.44912594918756 -2.2939665222821 0.0217924217843172 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.284702865585043 0.361076023458392 0.788484549204221 0.430413332704304 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.110357934846295 0.36447343783094 0.302787318338089 0.76205194853873 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.128422586563201 0.564458922648434 -0.227514494696344 0.820023699602876 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.534075931173726 0.51076830804539 -1.04563247711576 0.295730748726231 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) 0.0397216577984601 0.363777543089347 0.109192165797612 0.913050073943779 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.62273952369689 0.489414857686795 1.27241646614541 0.203225186644513 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.20066458399943 0.405613300885795 0.494718944278235 0.620798527145409 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.197679852691369 0.341308962204934 -0.579181546872697 0.562466680717016 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) 0.0378864756366931 0.363757933318724 0.104152987925344 0.917047941188921 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.144337853245143 0.549984165056457 -0.262440016305427 0.792982224939006 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.413137142767056 0.611737194343158 -0.675350700574378 0.499452979190124 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.175697259317667 0.399444350247806 0.439854160432282 0.660042737899316 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.401434130115683 0.402356608987887 -0.997707310252651 0.318421307361602 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.289493078225726 0.461346338052802 -0.627496209133437 0.530334020312785 1 FALSE StreptococcusStreptococcus anginosus (SP175) 0.190509209299361 0.506610421492654 0.376046763384878 0.706882130975705 1 FALSE KingellaKingella oralis (SP176) 0.0493959868246048 0.489737314564717 0.100862207872619 0.919659843816466 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.512396314420722 0.450826255250395 -1.13657159150176 0.255717421583673 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.240946195260291 0.354379505863572 0.67991007175525 0.496561403937095 1 FALSE GemellaGemella haemolysans (SP183) -0.556323999592704 0.410664181634634 -1.3546932614826 0.175515305700086 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.573590485466367 0.413661887345913 -1.38661671044091 0.165558670059223 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.186111142183546 0.553444289792706 -0.336278005963805 0.736661233868276 1 FALSE RothiaRothia dentocariosa (SP193) -0.195699402597771 0.626316215408951 -0.312461018544745 0.754690183735944 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.0390113177790599 0.414794516971659 0.0940497431448096 0.92506964250304 1 FALSE EikenellaEikenella corrodens (SP200) -0.299522601231539 0.366809342736954 -0.816562083715332 0.414178730693073 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.277431806028578 0.541664726809077 0.512183630015779 0.608522498813543 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.0743308670800796 0.427739871355403 -0.173775867198312 0.862041610993075 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.21449735652466 0.465290247935517 -0.460996888450552 0.644800837485567 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.433129664643944 0.476718619635566 -0.908564605626389 0.363579996798073 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.984261039683252 0.496008312607274 1.98436400089642 0.0472152761378763 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.124837312752361 0.538484809520563 -0.231830704497512 0.816669507904658 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.35810065461713 0.358060591784142 -1.00011188841751 0.31725636344925 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) -0.178644475417561 0.333784381654559 -0.535209210604841 0.592505197944542 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.761677330311269 0.448088088705937 1.69983837890216 0.0891613303239845 1 FALSE FilifactorFilifactor alocis (SP234) 0.416432414969514 0.394724288894922 1.05499566833185 0.291427305843363 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.00384586391616296 0.554808570077962 0.00693187546764561 0.994469207880247 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.229038313798177 0.349728377808996 0.654903428864062 0.512529932459051 1 FALSE LautropiaLautropia mirabilis (SP245) 0.305028549566423 0.501744497966501 0.607936012856464 0.543229913342143 1 FALSE ActinomycesActinomyces oris (SP249) 0.461638598467498 0.488756637300396 0.944516275047063 0.344905889069318 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.0267594019141985 0.344882458014564 -0.077589918803781 0.938154261834743 1 FALSE ArachniaArachnia propionica (SP260) -0.463380172402707 0.391500299570833 -1.18360106725504 0.236571017732887 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.457948191717154 0.498989925698818 -0.917750375572841 0.358749567701594 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.340114280144193 0.42518488386283 -0.799920912178802 0.423756620763821 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.280428037761234 0.48600371559488 0.577008012002508 0.56393404317648 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.0547565233351084 0.363623276515654 -0.15058585869365 0.880302417303999 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.156173044039388 0.400544370585902 -0.389901982172271 0.696609028122174 1 FALSE DialisterDialister invisus (SP28) -0.388472727922113 0.522749996974742 -0.743132912807808 0.457401214965079 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.0371961885688522 0.502587075183338 -0.0740094411605859 0.941002872905575 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.283102956427238 0.423753198887371 -0.66808452932171 0.504079636599332 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) 0.188958946348271 0.486899299095928 0.388086297719322 0.697952171694496 1 FALSE ActinomycesActinomyces israelii (SP293) -0.23671602872237 0.469978909228387 -0.503673726787041 0.614490673949257 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.339378922485227 0.411328635655523 0.825079736897891 0.409326322906707 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.3735152860523 0.473263512819867 -0.789233219833001 0.429975709354909 1 FALSE ParvimonasParvimonas micra (SP31) 0.554597496779973 0.50379431566918 1.10084111616725 0.270965813445133 1 FALSE ActinomycesActinomyces massiliensis (SP310) 0.0480555060448494 0.34579003744813 0.138973078575342 0.88947142276661 1 FALSE TreponemaTreponema denticola (SP311) 0.374968043201472 0.361684601281613 1.03672658961092 0.299863296413488 1 FALSE RothiaRothia mucilaginosa (SP318) 1.09475386250082 0.461841489156207 2.37041038582514 0.0177683507264827 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.407650779821917 0.390301428141036 -1.04445116115387 0.296276703843108 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) -0.302739773963965 0.395018224754894 -0.766394447121555 0.443441635852384 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.570549186047134 0.398433420079354 1.43198124779167 0.15214918806232 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.341037184297329 0.422201369924497 0.80775953985729 0.419229020912171 1 FALSE GemellaGemella morbillorum (SP332) 0.191702943192654 0.383554305690013 0.49980652113338 0.617211318441753 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.686508896724671 0.438056834856066 1.56716855462429 0.117075298464071 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.397829300651065 0.426793131041288 -0.932136137431366 0.351266174353924 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.20036713906507 0.398756385337738 0.502480076639685 0.615329863546191 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.0373746350952687 0.642944066858882 0.0581304611423872 0.953644710927629 1 FALSE NeisseriaNeisseria elongata (SP369) 0.146040082806619 0.336107716575738 0.434503808167435 0.663922630034512 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.142390473292858 0.380876951728277 -0.373849015139255 0.708516650391833 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.0655292681792683 0.371548406381728 -0.176368050713542 0.86000480303254 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.629007046930382 0.407540472800354 1.54342228296555 0.122728350596729 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.0901987230735202 0.3696457197866 -0.244013979454687 0.807219993084323 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -1.38533752072697 0.485723262287356 -2.85211277344052 0.00434296899264938 0.603672689978265 FALSE NeisseriaNeisseria mucosa (SP44) 0.534267400708343 0.349342474108072 1.52935139671296 0.126177354507152 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.521091322050651 0.382324657421488 1.36295504863601 0.172896677903283 1 FALSE GemellaGemella moribillum (SP45) 0.110342350783288 0.372751676403272 0.296021071851361 0.767213989181116 1 FALSE RothiaRothia aeria (SP465) -0.39987223054544 0.434028032175807 -0.921305079169328 0.356891170068979 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 1.02701853489358 0.525136543323373 1.95571713290795 0.0504984853220249 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.34146180457216 0.574396652651235 0.594470394275592 0.552197538096238 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.651094730705435 0.550433680648053 1.18287589149499 0.236858337584202 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.0650133655563853 0.597870981956988 0.108741463490299 0.913407553725078 1 FALSE StreptococcusStreptococcus constellatus (SP53) -0.081982179454388 0.38947469269953 -0.210494240039456 0.833281946746575 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.355364603087987 0.374110364301872 -0.949892430141927 0.342166913603044 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.585570643294957 0.613728187282355 -0.954120497362061 0.340022651702732 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.114986362054531 0.557450629797963 0.206271830917485 0.836578581047339 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.199126498318957 0.360545745705574 0.552291909392174 0.580748372838529 1 FALSE PrevotellaPrevotella denticola (SP60) -0.577020766949264 0.561932731233 -1.02685025249047 0.304490982339504 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 1.13018373593812 0.492420855927225 2.29515814030662 0.0217240631349342 1 FALSE TreponemaTreponema socranskii (SP63) -0.180680309368474 0.472183065844813 -0.38264885473012 0.701980141286243 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.687467071160704 0.579849457347407 -1.1855957825771 0.235781968574573 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.158226805613201 0.312936869245125 0.505618932006575 0.613124188533277 1 FALSE CampylobacterCampylobacter concisus (SP67) 1.12575656001965 0.358966574970517 3.13610413479893 0.00171208399789935 0.239691759705909 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.225614266592237 0.405229088435561 -0.556757333150119 0.577693238971608 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.0678575961214024 0.432551710967197 0.156877419279353 0.875341456292069 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.468542813119673 0.360829027354149 1.29851751826996 0.194109560526532 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.0462788776677702 0.383137500590343 -0.120789214306778 0.9038579932875 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) 0.0749068569708094 0.380949634122593 0.196631917348695 0.844115591761434 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) 0.516649204972858 0.341599942990793 1.51243937703696 0.130422123924296 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.428662912979369 0.416746808687123 1.02859315067051 0.30367089788042 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.237188009842717 0.440961364699849 0.537888415698651 0.590654086455325 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.162848293858228 0.455903986862082 -0.357198661453013 0.720943087895635 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.562410524157762 0.577847810895594 -0.973284857281183 0.330411746319243 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.0284098499609728 0.4765087356905 0.0596208376322936 0.952457621858596 1 FALSE VeillonellaVeillonella parvula (SP88) -0.442685017948154 0.419484342224836 -1.05530760838478 0.291284662531855 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.204554480380839 0.449286291870843 0.45528760632573 0.648902341372553 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.208301513108422 0.393286465131743 0.529643228476335 0.596359316515009 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.0901544604756827 0.577272248577727 0.156173210643338 0.87589649242184 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.257256617344618 0.430859888624137 -0.597077203371413 0.550455837204468 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0086221034159527 0.367789889829106 -0.0234430136727221 0.981296894473728 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.0182307596123773 0.3647721290712 0.0499784883751874 0.96013953068445 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.542625040063876 0.494406712807537 1.09752765487857 0.27241079843732 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 0.207316458646434 0.444048025317689 0.466878460946003 0.640586836325894 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.51247058034628 0.438263888166683 1.16931965918984 0.242274865386461 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.854370335425578 0.423059385777316 -2.01950450491906 0.0434348095573025 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.161061767448593 0.431395268211082 -0.373350797556235 0.708887374109454 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.527154447289651 0.520161177379546 -1.01344442879289 0.310847927050812 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.457831362949535 0.458198648394032 -0.999198414386894 0.317698583841779 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.25973065994928 0.464846076037813 -0.558745514565023 0.576335412053433 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.00354242690910574 0.548536935448507 0.00645795511693173 0.994847333133354 1 FALSE