Group24 Weeks.B.Plaque 2...1 Group24 Weeks.B.Plaque 2...2 Group24 Weeks.B.Plaque 2...3 Group24 Weeks.B.Plaque 2...4 Group24 Weeks.B.Plaque 2...5 Group24 Weeks.B.Plaque 2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) -0.143872628091433 0.350640370378692 -0.410313929157815 0.681575675451234 1 FALSE StreptococcusStreptococcus mutans (SP100) -1.29286482148883 0.721435857225488 -1.79207175321304 0.0731214729318325 1 FALSE TannerellaTannerella forsythia (SP101) 0.411161411449274 0.446049946761511 0.921783343848507 0.356641597163107 1 FALSE PrevotellaPrevotella oralis (SP104) 0.135908357987041 0.378758387394718 0.358826002301584 0.71972525929466 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.0396807085975327 0.379573267334526 0.104540314116909 0.916740577488088 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.767919248294348 0.513853499570883 -1.494432263156 0.135062674127693 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 0.318268037383315 0.460898205301664 0.690538678003757 0.48985549547807 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 0.110351354410713 0.450031331300307 0.245208159378298 0.806295258947783 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) 0.102723395569274 0.533712611304206 0.192469492744896 0.847374462402692 1 FALSE PrevotellaPrevotella salivae (SP111) -0.103599497314326 0.36405231893852 -0.284573100966353 0.775971221824107 1 FALSE CatonellaCatonella morbi (SP118) -0.248620741336281 0.43847477276875 -0.567012646511828 0.570705589525783 1 FALSE PrevotellaPrevotella oris (SP12) -0.613665737099713 0.501861607000259 -1.22277880702557 0.221413252115334 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.0098177988724389 0.494385456179633 -0.0198585916104936 0.984156177732833 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.339871875420353 0.330400440068652 -1.02866653370599 0.303636401246359 1 FALSE CampylobacterCampylobacter showae (SP122) -0.795388590349835 0.447263496444915 -1.77834452547995 0.0753472877389865 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.611368047735422 0.370093825660932 -1.65192717453097 0.0985493976208767 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.210883912166732 0.428959352479786 -0.491617471323625 0.622989790055163 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.217507792923689 0.549693124921128 -0.395689491213663 0.692334108914984 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.0644389674368959 0.356374490273953 0.180818125863499 0.856510335242315 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.253898786194508 0.463699202586703 0.547550620700136 0.584000503175143 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.454777588125864 0.337880366332147 1.34597222402323 0.178311474527103 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.975848437530786 0.664588507278286 1.46834985384748 0.142009215454557 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.116283723132063 0.454424674420343 0.255892185608963 0.798034088768755 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.297036809722284 0.399603244518442 0.743329324265724 0.457282321940847 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.135756134192106 0.418616550439268 0.324297102084599 0.745713113439629 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.745582267940788 0.609595172615064 1.22307771031447 0.221300346528035 1 FALSE StreptococcusStreptococcus cristatus (SP15) -0.599259328832729 0.552933041072025 -1.08378281694088 0.278461105641578 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) 0.051439327846343 0.334669985737079 0.153701646513214 0.877844986480948 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) -0.0140466953932125 0.369831543609809 -0.0379813340314541 0.969702564573839 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.0583452941961283 0.475949381900657 0.122587183458737 0.902434004007575 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.235065016334692 0.442324061293268 -0.531431673979951 0.595119677318364 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.0298177601850081 0.355201381423862 -0.0839460704389168 0.933099309890258 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) 0.135356001811146 0.324052576349947 0.417697656768429 0.676168185750837 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.156323421182352 0.459807831693415 0.339975551539938 0.733874939511991 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.305099472725701 0.666590477020509 -0.457701517263521 0.647166897802595 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.538356235310965 0.486850647779138 1.10579340454158 0.268815950382055 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.964754968456133 0.525275593627744 -1.83666437230252 0.0662594579079472 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.0200589722159608 0.46356252324507 0.0432713414267017 0.965485236045414 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.0788240557571895 0.516583397891654 -0.152587280347948 0.87872375634178 1 FALSE KingellaKingella oralis (SP176) -0.26117191431921 0.527719889877934 -0.494906330666484 0.620666241759194 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.134686395173717 0.526200216367678 -0.255960356883635 0.797981448425771 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.536322990289202 0.398980370565232 1.34423402717632 0.178872721530562 1 FALSE GemellaGemella haemolysans (SP183) -0.733014379451388 0.442991602553927 -1.6546913648598 0.0979871195750409 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.655824972261092 0.356562455782312 -1.83929901094659 0.0658712184533076 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.494795878312231 0.576739908577665 -0.85791857118485 0.390937428713545 1 FALSE RothiaRothia dentocariosa (SP193) -0.248315050338311 0.557996674045083 -0.445011703274505 0.656311296552464 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.225498690093287 0.472973714352508 0.476767911726322 0.633527397717177 1 FALSE EikenellaEikenella corrodens (SP200) -0.641956481431208 0.425507122397561 -1.50868563095734 0.131379139278646 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.0926671831951311 0.607486072265382 0.152542070387828 0.878759411294962 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.243895716506194 0.498274346702917 0.489480781260469 0.62450135758628 1 FALSE PrevotellaPrevotella multiformis (SP204) 0.366206141882412 0.364151531225535 1.00564218596023 0.314587723132293 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.14513251365805 0.407645915065873 -0.356025924200903 0.721821150821578 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.502343711405081 0.474580577440247 -1.05850035859997 0.289827387371111 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.436748857625544 0.518968839741062 0.841570483968669 0.400028416520175 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.101925083281634 0.493367941492453 -0.206590405881069 0.83632975363033 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.255008914414452 0.387274547193576 0.658470628298192 0.51023576449532 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.00356162614178572 0.433039797157079 0.00822470859530214 0.993437705980095 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.36706390978421 0.46055416769077 -0.797004859655656 0.425448208970469 1 FALSE FilifactorFilifactor alocis (SP234) 0.220529672189079 0.403630688188962 0.546364978288856 0.584815078753619 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.315693285325188 0.615905676820754 0.51256758495029 0.608253832685533 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) -0.131189724384622 0.425069929909916 -0.308630922004821 0.757602296065678 1 FALSE LautropiaLautropia mirabilis (SP245) 0.362068281926778 0.547651459976139 0.661129036235114 0.508529565655681 1 FALSE ActinomycesActinomyces oris (SP249) 1.00755678873001 0.517700564303546 1.94621535729918 0.0516288759331153 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) -0.364887104805935 0.344826986160108 -1.05817444530433 0.289975919456987 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.00554188510189743 0.361030811414043 -0.0153501721368091 0.987752815611083 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.531561458302943 0.40170431769594 1.32326548380616 0.185747105883199 1 FALSE ArachniaArachnia propionica (SP260) -0.549203484426825 0.409898642985865 -1.33985192150481 0.180293491521246 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.265908975319864 0.526565881496136 0.504987095943881 0.613567899348438 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.645838258501484 0.467101898017416 -1.38264961294891 0.166772328702401 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.349184466635666 0.494042019176276 -0.706791028054387 0.479696350913168 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) 0.260981015848718 0.340547266406324 0.766357688325496 0.443463501571086 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.416340892899941 0.329905948386113 -1.26199874520803 0.206949237894067 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.13368407828304 0.39567732918498 -0.337861354246409 0.735467671596596 1 FALSE DialisterDialister invisus (SP28) -0.272428213911253 0.495252201286712 -0.550079763812172 0.582264665758304 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.692062957426713 0.545187456144337 -1.26940366955818 0.20429712807553 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) 0.344441784678306 0.399017784494087 0.863224142039237 0.388014242511969 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.250328217593932 0.459546255053524 -0.544729099282456 0.585939848181607 1 FALSE ActinomycesActinomyces israelii (SP293) 0.0318052945769888 0.503740737806679 0.0631382220851766 0.949656438178601 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.654362557523003 0.355052303074623 1.84300327545115 0.0653285322538217 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.455569058487216 0.427646778443472 1.06529285721589 0.286743424093289 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.107346893105772 0.554622802132487 -0.193549368495183 0.846528746451707 1 FALSE ParvimonasParvimonas micra (SP31) 0.388132981121224 0.51991394237096 0.746533126907934 0.455345428013587 1 FALSE ActinomycesActinomyces massiliensis (SP310) 0.0989233032657692 0.390310941650852 0.25344742539721 0.799922483471949 1 FALSE TreponemaTreponema denticola (SP311) -0.237283907987288 0.367124918800695 -0.646330161304319 0.518065558762044 1 FALSE RothiaRothia mucilaginosa (SP318) 0.516338246063013 0.492704321606097 1.04796776366782 0.294653459374061 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -0.344911538370696 0.383901208673151 -0.898438271561551 0.368951940515412 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.128554370657705 0.474282934271049 0.271049960621685 0.786352606943362 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.0567258756870448 0.400068664017163 0.141790349480137 0.887245607050411 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.105004031600143 0.437375617984725 0.240077469530573 0.810270200208343 1 FALSE GemellaGemella morbillorum (SP332) -0.282765958018876 0.408473499372991 -0.692250435959549 0.488780070132438 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) -0.300936975295778 0.509841532167256 -0.590255905627269 0.555019096571863 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.780599294507272 0.489838966403178 1.59358349997982 0.111029352539848 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.0746367449872407 0.358390863566102 -0.208255155403744 0.835029744734789 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.24037396631958 0.709468015207406 0.338808742842774 0.734753814594325 1 FALSE NeisseriaNeisseria elongata (SP369) 0.441874024787733 0.382257430137041 1.15595928280405 0.247697812056779 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.0658612254273493 0.331648804468809 -0.198587254167362 0.842585624734055 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.344941502627607 0.370585471807649 -0.930801471911579 0.351956268176406 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.882876923606256 0.412756682092423 2.13897669476994 0.0324375558681745 1 FALSE AlloprevotellaAlloprevotella rava (SP42) 0.310403854453843 0.366694213866923 0.846492370797245 0.397278128088092 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.602498188743363 0.519086953189474 -1.16068836837716 0.245768653779154 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.36883310434647 0.484839241480865 0.760732780663396 0.446816691020617 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.292343168573479 0.451892544645415 0.646930718458457 0.517676783676442 1 FALSE GemellaGemella moribillum (SP45) 0.261008486683493 0.379775720383021 0.68727007197894 0.491912554691249 1 FALSE RothiaRothia aeria (SP465) 0.44218113555304 0.52036047202259 0.849759271364954 0.395458937782335 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.548957566561827 0.573431086450167 0.957320904871336 0.338405307004262 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.312637157629697 0.548702349131205 0.569775504195882 0.56882997180461 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.642307734314356 0.562177420214339 -1.14253563238002 0.253231443632932 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.00942484138305469 0.609096702754107 0.0154734729977015 0.987654447441014 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.0885241892095803 0.450377901152165 0.19655535714145 0.844175508839382 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.0978035683924891 0.38943976792788 0.251139139982749 0.801706536027914 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.160227352749595 0.659875652393007 -0.242814463859271 0.808149130302444 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.732285978819071 0.531550617272684 1.37764110326188 0.168314123809445 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.163369054378569 0.358941678919207 0.455140943427027 0.649007843949207 1 FALSE PrevotellaPrevotella denticola (SP60) -1.05487501907821 0.530923319229252 -1.98686887705287 0.0469369293794014 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 1.14840852528372 0.527945135991864 2.17524217384098 0.0296119733164007 1 FALSE TreponemaTreponema socranskii (SP63) 0.0444887805481648 0.461830672462282 0.0963313681851615 0.923257398718402 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.749959201113524 0.651735412266348 -1.15071114289403 0.249851090807084 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.0824482339838063 0.348126068922756 -0.23683441529942 0.812785251419224 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.115198796859609 0.465045079010258 -0.247715333543112 0.804354667118319 1 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.522707180559361 0.484321041082056 -1.07925763330774 0.280472893788044 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.920028954249126 0.520902431296038 1.76622127095863 0.077358733790781 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.0541237312052665 0.371638205790941 -0.145635541130862 0.884209109333268 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.465064066826493 0.396923003927798 -1.17167325205241 0.241328265901158 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) 0.304926466848697 0.409177523836814 0.745218026614546 0.456139926942476 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_848 (SP76) 0.0736683363847477 0.418790155356197 0.175907517028642 0.860366599706866 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.749823928385765 0.432514501807206 1.73363881500556 0.0829821889184836 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.108011998699127 0.414388177564298 -0.260654151221211 0.794359226046317 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.0302086468793916 0.515393052624554 0.0586128329156923 0.953260489068555 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.052231722289307 0.551574970716743 -0.0946955990795495 0.924556613696201 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.103387350845999 0.479838975802158 -0.215462594869798 0.829406672135792 1 FALSE VeillonellaVeillonella parvula (SP88) 0.102449088132335 0.413238387491503 0.247917645682038 0.804198126755449 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.24285833898439 0.425702998193694 0.570487734441302 0.568346938869987 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.00910169557522495 0.351648956495592 -0.0258829022725652 0.979350737488614 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.0579352308773483 0.607589700658171 0.0953525558688536 0.924034799233896 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.0347340139282649 0.467975130360651 -0.0742219226510962 0.940833802207471 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0837513316854951 0.394434833463041 -0.212332493431625 0.831847647235482 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.253682457323838 0.359756076699696 -0.70515127819675 0.480716098018911 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.496349204023276 0.47005811351569 -1.05593157473859 0.290999477348644 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 0.617557401588489 0.443402886624955 1.39276811274086 0.163689923927325 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.0889455586853769 0.445807563674054 -0.199515589085896 0.841859450157195 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.651335759262019 0.478942919335234 -1.35994443798452 0.17384750713499 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.252189082096349 0.441124072784037 0.571696485536881 0.567527615811874 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.36246680702333 0.501522752075338 -0.722732529129367 0.469844226509967 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.0619359904916333 0.528591899926393 0.117171660216999 0.906724024068018 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.504361005987331 0.491475307740752 -1.02621840414692 0.304788648230763 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.426847292942671 0.530079017574311 0.805252195976294 0.42067416159675 1 FALSE