Group12 Weeks.A.Plaque 1...1 Group12 Weeks.A.Plaque 1...2 Group12 Weeks.A.Plaque 1...3 Group12 Weeks.A.Plaque 1...4 Group12 Weeks.A.Plaque 1...5 Group12 Weeks.A.Plaque 1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.460826406859973 0.299381997760782 1.53925890770557 0.123741101536878 1 FALSE StreptococcusStreptococcus mutans (SP100) 0.590990547609287 0.547503528976866 1.07942783257249 0.280397049061683 1 FALSE TannerellaTannerella forsythia (SP101) -0.0439788328412063 0.276133230865058 -0.159266715937924 0.873458742836508 1 FALSE PrevotellaPrevotella oralis (SP104) 0.499127325579857 0.299370703485373 1.66725507796471 0.0954636949918208 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.286880233059609 0.383929479366186 0.74722116554636 0.454930069971739 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 0.47248201543243 0.443492010428672 1.06536759247531 0.286709616129227 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.0977086578557584 0.375091368752574 -0.260492951839185 0.794483551326091 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 0.0456728425294434 0.365913082379622 0.12481882919414 0.900666980428534 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.242982607418318 0.456332792793283 -0.532467995409632 0.594401902470894 1 FALSE PrevotellaPrevotella salivae (SP111) 0.0169532561808159 0.286093461542492 0.0592577547540277 0.952746808775373 1 FALSE VeillonellaVeillonella atypica (SP116) -0.12014587824365 0.306491287227314 -0.392004220839537 0.695055095122098 1 FALSE CatonellaCatonella morbi (SP118) -0.0418087581485438 0.33505593743051 -0.124781427451095 0.900696591206636 1 FALSE PrevotellaPrevotella oris (SP12) 0.0330781394375854 0.442383596057233 0.0747725271289352 0.940395700784939 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.0599078128149807 0.365757156180262 0.163791225414754 0.869895499495955 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.0521000550305307 0.352374116740184 0.147854375663311 0.882457695304896 1 FALSE CampylobacterCampylobacter showae (SP122) 0.239731681212439 0.305213951976384 0.785454530043857 0.432187119895165 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.0944040442329697 0.315128540344886 -0.299573133330454 0.76450277995467 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.43675446439261 0.33824114705099 -1.29125172439995 0.196616404570244 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.135896185974466 0.416344381001761 -0.326403314600974 0.744119230050394 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.467899580285975 0.304012471294792 1.53908021698316 0.12378471403145 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.170066680330394 0.397525040896007 -0.427813754693464 0.668786721986021 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.0512967365485926 0.296964681218657 0.172736826272019 0.862858295698812 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.777325804043897 0.501153590119801 1.55107300310485 0.120884190038575 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.121874588769286 0.381457295174976 -0.319497333806087 0.749349412849557 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.132800540000601 0.291587896667928 0.455439136940036 0.648793344583274 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) -0.0679770623864693 0.277604164161962 -0.244870470843548 0.806556726576671 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.308992620660681 0.499527483504058 0.618569810199783 0.536199795289084 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.657488089664501 0.443493985366204 1.48251861662024 0.138202353799146 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.376976770312721 0.359344689984775 -1.04906731842536 0.294147136404016 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.144496470164738 0.338884719317855 -0.426388272848645 0.669824945230562 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) 0.0916181089862591 0.342517540733942 0.267484429527145 0.789096201005216 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.33722390393165 0.263275286187157 -1.280879450614 0.200236011710352 1 FALSE ScardoviaScardovia wiggsiae (SP166) -0.153183810985221 0.424180786284972 -0.361128594076182 0.718003318584709 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.712165407017303 0.512241102762892 1.3902933661045 0.164439811496506 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.0699356889801907 0.382195788090742 0.18298393430643 0.854810624351278 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.0345710509627045 0.438105081359474 0.0789104085609504 0.937103884225855 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.185514261960461 0.382826906071411 -0.484590448106736 0.627966890684224 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.151997657724048 0.449447670531642 -0.338187663859183 0.735221771578661 1 FALSE KingellaKingella oralis (SP176) 0.815225940065734 0.395916602299687 2.05908500762657 0.0394860957890556 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.669924727841675 0.39969358064043 -1.67609579010064 0.0937194312456384 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.388949784215626 0.315150524726979 1.23417146315267 0.217139018690455 1 FALSE GemellaGemella haemolysans (SP183) 0.638695216664287 0.362915214785307 1.75990201193997 0.0784244221500122 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.33284162901398 0.325385427983577 1.02291498140101 0.306348045440675 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -1.42249272730936 0.434795252750627 -3.2716381292351 0.00106926341321706 0.149696877850388 FALSE RothiaRothia dentocariosa (SP193) 0.282056800340243 0.536930371444493 0.525313551515872 0.599365238361716 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.101783159395803 0.342757533047483 0.296953821819295 0.766501764525674 1 FALSE EikenellaEikenella corrodens (SP200) 0.268087331917452 0.283881205644408 0.944364496793282 0.344983417554918 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.400666474111047 0.499132371343023 0.802725884183724 0.422133188654346 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.0685579191210878 0.39467832318087 0.173705813302723 0.862096668630526 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.41578647879233 0.40815706026566 -1.01869235955812 0.308349041000595 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.435516896975595 0.414714885465769 -1.05015978986735 0.293644653241238 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.2232216305838 0.441733912725266 -0.505330526258759 0.613326705694372 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.073733918501759 0.417421491833934 0.176641404298112 0.859790069511223 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.148277553613748 0.309796661553902 0.478628636183507 0.632202842628995 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.294504789102449 0.336948279214976 -0.874035593203171 0.382098870468924 1 FALSE FilifactorFilifactor alocis (SP234) -0.209399968554008 0.266711268678451 -0.785118565074435 0.432384055749168 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.106182631425588 0.487735977344275 0.217705144500008 0.827658855088585 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.30970118698984 0.311082093925848 0.99556095653536 0.319463513032851 1 FALSE LautropiaLautropia mirabilis (SP245) 0.647937465885462 0.406819488584885 1.59269033088681 0.111229677730554 1 FALSE ActinomycesActinomyces oris (SP249) -0.173220233461293 0.421283247680691 -0.411172849656211 0.680945795075109 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) -0.191753736511856 0.28199699762967 -0.679985028647981 0.496513940603131 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.212452991998203 0.274725754651634 -0.773327539922875 0.43932856110626 1 FALSE ArachniaArachnia propionica (SP260) 0.182726316628526 0.374622611084954 0.487761045974582 0.625719106169621 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.278286369345526 0.422520338234514 -0.658634257721973 0.510130658717951 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.335355551006243 0.312665322987073 1.07257033751744 0.283463939506044 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.292237976664374 0.413720251548528 0.706366138883814 0.47996047271203 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) 0.0944980716902465 0.301520064759751 0.313405583026595 0.753972543094808 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) -0.119072408808852 0.317551610280521 -0.374970256657381 0.707682587204836 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) 0.123202916392483 0.275356046766501 0.447431308806368 0.654563674285823 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.418318608694725 0.310026322858342 -1.34930029436844 0.177240531128921 1 FALSE DialisterDialister invisus (SP28) 0.00564835523151147 0.422360686859586 0.0133732977695182 0.989329970230708 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.0983176472944474 0.470226776633675 -0.209085599076891 0.834381416527644 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.239398582596913 0.293904677421449 -0.814544990223559 0.415332809452176 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.0592928600374838 0.404215200528088 -0.146686368944118 0.88337957822111 1 FALSE ActinomycesActinomyces israelii (SP293) -0.185689861489227 0.340857229447984 -0.54477313504528 0.585909557690067 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.339050727608399 0.302263868503832 -1.12170445408066 0.261988122123175 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.337125669552053 0.313101553503204 1.07672946933686 0.281601142906345 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.386137781896707 0.350861117289505 -1.10054310058556 0.27109556128352 1 FALSE ParvimonasParvimonas micra (SP31) -0.17949507300738 0.441294502371448 -0.406746678335673 0.684194053137798 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.0770841405516015 0.256428131689601 -0.300607191744896 0.763714046764911 1 FALSE TreponemaTreponema denticola (SP311) 0.369532900238085 0.280997593250571 1.3150749654591 0.188484709271089 1 FALSE RothiaRothia mucilaginosa (SP318) 0.299862300071932 0.416588014849791 0.719805393777479 0.471644823494281 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.12694069456315 0.283988986879036 0.446991610337411 0.654881117449507 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) -0.0502845971901411 0.253998791267613 -0.197971797185292 0.8430671295818 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.0540022508506774 0.294102175366935 -0.183617311851916 0.854313681140915 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.626901486296099 0.300671675751981 2.08500346674896 0.0370689858506113 1 FALSE GemellaGemella morbillorum (SP332) 0.251851552175828 0.35426867766503 0.710905502105834 0.477142796238873 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.0307990334055855 0.348014846068999 0.0884991940817351 0.929479924856766 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.261378937201043 0.346518938401148 -0.754299139917303 0.450669618670186 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.281835301996699 0.318644205892971 0.884482745282883 0.376435672838058 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.79977643585124 0.607004268289288 -1.31757959149981 0.187644421175422 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.720368315198008 0.388404038081882 1.8546880170338 0.0636407909222212 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.152696038459288 0.324528422664716 0.470516687584694 0.637985914619449 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.245374584066706 0.293271805218167 -0.836679761575344 0.402772598118774 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.247574721283299 0.313635690804765 -0.78937036996026 0.429895568471328 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.736325547053845 0.440677353617585 -1.67089490986828 0.0947424371107559 1 FALSE NeisseriaNeisseria mucosa (SP44) 0.0885730765127932 0.337456999031285 0.262472186877303 0.792957425546368 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.668015149690524 0.371312277734637 1.7990656106662 0.072008302719715 1 FALSE GemellaGemella moribillum (SP45) -0.396777720135044 0.246312357426926 -1.61087216362158 0.107207588305339 1 FALSE RothiaRothia aeria (SP465) 0.913379850028418 0.350477264670904 2.60610299753987 0.00915789186865614 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.0157714836645779 0.436715115989503 -0.03611389458971 0.971191543274944 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.271372337551288 0.569428725764981 0.476569455091541 0.63366873833987 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.424205472635908 0.468853026401865 -0.904772815249594 0.365585756249867 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.654345140885686 0.509594980246091 1.28404942405377 0.199124662691157 1 FALSE StreptococcusStreptococcus constellatus (SP53) -0.00774410333807597 0.281439896231171 -0.0275160112044494 0.978048169588125 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.111162272057926 0.32204191426938 0.34517951587178 0.729959417430364 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.336583774704788 0.514362928010854 0.654370205112617 0.512873325296987 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.300706448655681 0.474558612762783 -0.633655022938114 0.526305983611378 1 FALSE PrevotellaPrevotella denticola (SP60) -0.239761590093059 0.442602855233663 -0.541708186601013 0.588019549175456 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.418577608610791 0.417374942805976 1.00288149977746 0.315918039775264 1 FALSE TreponemaTreponema socranskii (SP63) -0.140254846467899 0.38430869968436 -0.364953607823849 0.715146036768378 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.156181992907124 0.517055350637128 -0.3020604906509 0.762605950345908 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.11021686494959 0.317970191245021 0.346626407079331 0.728872004516925 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.263975278004627 0.341082574892756 0.77393363788117 0.438970036204887 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.00254617770420351 0.367531463947343 0.00692778157509885 0.994472474255473 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.0189089924510053 0.341070645644032 0.0554401051292471 0.955787845679014 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.375418555657805 0.317684623416214 -1.18173348026968 0.237311469324878 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.11334981360106 0.27416716541325 -0.413433218489927 0.679289241018201 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.716536203648536 0.413247924396091 -1.73391361782557 0.0829334112550423 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.224187417313218 0.324512712393246 -0.690843251285474 0.489664051856362 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.369779664013672 0.385389035666785 0.95949710498093 0.337308377400309 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.254736697916171 0.386061370738014 -0.659834723762191 0.509359897451834 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.501796720405816 0.481453117248441 -1.04225458809705 0.297293660501567 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.139966105710684 0.356741883246903 0.392345592944613 0.694802880307311 1 FALSE VeillonellaVeillonella parvula (SP88) 0.320454119014036 0.391682166916401 0.818148351090063 0.413272482865367 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.249659239704845 0.385118751893266 0.648265602434329 0.516813177739605 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.0895260127681063 0.252034460373423 0.355213380882367 0.722429741050662 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.112893358658239 0.461311878169421 0.244722418824814 0.806671368055905 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.000281386254441879 0.393160456588285 -0.000715703346373271 0.999428951398565 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.0308155972812749 0.288448351795746 0.106832287615551 0.914922032234848 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.391321560950417 0.330389196448893 1.18442601984702 0.236244465294477 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.7131975166271 0.412066265530875 -1.73078355664051 0.0834903757428193 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.192715299889487 0.348997899122158 -0.552196160418809 0.580813964712508 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.622221299310407 0.274987182581858 -2.26272836962205 0.0236524388763951 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.567609219788966 0.419396175281323 1.35339627121832 0.175929068047559 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.279664482401247 0.334082704630323 -0.837111525155747 0.402529882696105 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.290037606372002 0.439849113265405 0.65940250332389 0.509637335044676 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.0297147554123609 0.359748223212328 -0.0825987551711211 0.93417059112387 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.110152633310125 0.377408044215231 0.291866151234726 0.770388964597479 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -1.10941011069653 0.430363367094266 -2.57784513163159 0.00994185441635536 1 FALSE