Group24 Weeks.A.Plaque 1...1 Group24 Weeks.A.Plaque 1...2 Group24 Weeks.A.Plaque 1...3 Group24 Weeks.A.Plaque 1...4 Group24 Weeks.A.Plaque 1...5 Group24 Weeks.A.Plaque 1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas catoniae (SP10) 0.151747067614657 0.311180310837126 0.487649964762977 0.625797798200189 1 FALSE StreptococcusStreptococcus mutans (SP100) 1.52491883014417 0.625819922961257 2.43667351293093 0.0148230560354874 1 FALSE TannerellaTannerella forsythia (SP101) -0.0102331412373231 0.321262234994589 -0.0318529230100621 0.974589341565677 1 FALSE PrevotellaPrevotella oralis (SP104) 0.575242021454701 0.320095271736554 1.79709627803606 0.0723203365039983 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.833344725763269 0.301348911023036 -2.76538157358587 0.00568562455440565 0.813044311280008 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.16462655207867 0.40887282924707 -2.84838333284044 0.00439419612507547 0.632764242010867 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.380595155424389 0.407315223421922 -0.934399535148594 0.350097837445647 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.0360736737682048 0.391966996806862 -0.0920324263575175 0.926672276402326 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.493404608504168 0.472320158671803 -1.04464016503478 0.296189308816683 1 FALSE PrevotellaPrevotella salivae (SP111) 0.136254472083936 0.331964789580824 0.410448566716929 0.681476925719898 1 FALSE VeillonellaVeillonella atypica (SP116) -0.334721783164975 0.304331233446805 -1.09986010760043 0.271393078310075 1 FALSE CatonellaCatonella morbi (SP118) 0.589770245610609 0.378765126603849 1.5570869760337 0.119449836780755 1 FALSE PrevotellaPrevotella oris (SP12) 0.0785671535958527 0.434290773632314 0.180909101380934 0.856438924861038 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.518299779090027 0.409090897091244 1.26695505271638 0.205171361960732 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) -0.301897682595654 0.319365846821544 -0.945303593356208 0.344503904429595 1 FALSE CampylobacterCampylobacter showae (SP122) 0.353986237995791 0.330644474242393 1.07059474926016 0.284351685431967 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) -0.0485488352755359 0.344733557773103 -0.140830024176207 0.888004223573896 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.451542184877725 0.378166891892202 -1.19402886545245 0.232466676907268 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0256555074050276 0.493440685749653 0.0519930928801521 0.958534197054763 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.00649558761472588 0.316772789441322 -0.0205055100413828 0.983640116624189 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.347126575083264 0.441000385017025 -0.787134403680538 0.431203191661163 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.186751063936613 0.340990481668011 0.547672366170134 0.583916889922923 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.990703893232908 0.542115936187456 1.82747605650599 0.0676282230213132 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.37638026881126 0.403538825026057 0.932699025396024 0.350975388242727 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.0751276910926069 0.340858265374311 0.220407420691724 0.825553866634663 1 FALSE LeptotrichiaLeptotrichia buccalis (SP146) 0.171594760218866 0.375039730914439 0.45753755155614 0.64728471781389 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.1107085286186 0.496178553355359 0.223122357606843 0.823440278079869 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.705405540584381 0.450922980069214 1.56435926258649 0.117733221924285 1 FALSE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP153) -0.16122537191268 0.263503017987927 -0.611853986128034 0.540634367630524 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.075094326643736 0.422663201958826 -0.177669421647573 0.858982601122442 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.0348399899773175 0.385884544519309 -0.0902860466223574 0.928059908046113 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.171034719370131 0.332380990876055 -0.514574311001768 0.606850520164227 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.172433230985023 0.314875589358093 -0.547623368761442 0.583950540054518 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.0793390082775694 0.439020887064318 0.180718071999034 0.856588872943531 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.368719536430024 0.555165670475062 0.664161269400007 0.506587099268196 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.415577821734261 0.3859438023854 -1.07678324970035 0.281577110217758 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.193426259157832 0.492459178448242 0.39277622922437 0.694484762924912 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.493999681354303 0.458657569414103 1.07705555145497 0.281455448815662 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.192821374174881 0.444544911001348 -0.433750042803429 0.664469962636796 1 FALSE KingellaKingella oralis (SP176) 1.03600762120834 0.457474457334815 2.26462396883092 0.0235357647694007 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.201847269900068 0.469410791024568 -0.430001341595712 0.667194665277984 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.257527445737319 0.336532398496243 0.765238196643328 0.444129718533888 1 FALSE GemellaGemella haemolysans (SP183) 0.144505726670104 0.367880507309836 0.392806152538 0.694462660129624 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) -0.0380230288568967 0.340733089015098 -0.11159182974217 0.911147050479844 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 0.0596427769957543 0.488882719281945 0.121998128883254 0.902900500137122 1 FALSE RothiaRothia dentocariosa (SP193) 0.490168933788773 0.545193841409042 0.899072763775067 0.368613904339495 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.414176012403657 0.423442232392727 0.978116920608723 0.328016500043451 1 FALSE EikenellaEikenella corrodens (SP200) -0.0405489171201827 0.287489293212127 -0.141044964378076 0.887834420934921 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.254560352727392 0.528210156231293 0.481930060837235 0.629855630583551 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) -0.430577009304794 0.379212902176031 -1.1354492603865 0.256187129934933 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.875200022096631 0.38005921370781 2.30279911795398 0.0212901481872582 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.277924832525474 0.430963745010607 -0.644891445610196 0.518997535688927 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.31635856574379 0.463639347394848 -0.682337613322473 0.495025494433902 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.0723137220328179 0.43409356175109 0.166585566809864 0.867696151018685 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.104614796074381 0.333823736667201 -0.313383335525583 0.753989443376536 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.604740096868492 0.358385760586576 -1.68739990081834 0.0915264829030566 1 FALSE FilifactorFilifactor alocis (SP234) 0.0427009374549002 0.321608675018689 0.132772965320102 0.894372935580586 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 1.23894602870384 0.506703837268093 2.44510883395643 0.0144808436552501 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.351003356472492 0.329393815027874 1.06560396843757 0.286602704534939 1 FALSE LautropiaLautropia mirabilis (SP245) 0.398914479490119 0.44572905634081 0.894970776114502 0.370802710217669 1 FALSE ActinomycesActinomyces oris (SP249) 0.143668082872852 0.446374347873623 0.32185559846178 0.747562091985469 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) -0.278919013240498 0.293763921345046 -0.949466537495218 0.342383383262621 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.258646550413524 0.340667163387114 -0.759235342326239 0.44771178782431 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.151159658762728 0.353960853421879 0.42705191068845 0.669341518292629 1 FALSE ArachniaArachnia propionica (SP260) 0.14509641392699 0.429807966375856 0.337584282465594 0.735676488311 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.302747692537451 0.434380994827281 -0.696963486300384 0.485825645026589 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.842682059059329 0.395237693811174 2.1320893028536 0.0329995058529013 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.218807665417011 0.411807703348363 0.531334561344797 0.595186959546348 1 FALSE LeptotrichiaLeptotrichia sp._HMT_498 (SP271) -0.0735957571179696 0.310344081583166 -0.237142454086876 0.812546277936966 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) -0.448530532892778 0.294022755153302 -1.52549598638689 0.127135433879327 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.135823220483565 0.30785336960319 -0.44119452276464 0.659072178124068 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.158468225546981 0.341216453475605 -0.464421407387703 0.642345855579227 1 FALSE DialisterDialister invisus (SP28) -0.181646421882965 0.471388567694981 -0.385343290719138 0.699983091869789 1 FALSE ActinomycesActinomyces dentalis (SP286) 0.637189023033428 0.513510475445683 1.24084912285461 0.214661490528533 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.0894159436291585 0.363144084286745 -0.2462271795086 0.805506376904484 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.457403341187248 0.40810700973953 -1.12079266043282 0.26237612905067 1 FALSE ActinomycesActinomyces israelii (SP293) 0.30769509547142 0.428268830028946 0.718462502747687 0.472472160277636 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.237486312272661 0.341394165443527 -0.695636704757761 0.486656373582381 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.64835522811361 0.367791779258225 1.76283229989869 0.0779287779913614 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.261801429921567 0.416600921569819 -0.628422589501381 0.529727142765191 1 FALSE ParvimonasParvimonas micra (SP31) 0.0999543227848479 0.45590700946571 0.219242785720683 0.826460927943386 1 FALSE ActinomycesActinomyces massiliensis (SP310) 0.0948340074218913 0.366332231609947 0.258874320190493 0.795732212455941 1 FALSE TreponemaTreponema denticola (SP311) 0.414978055306742 0.324388520392409 1.27926245603497 0.200804648785433 1 FALSE RothiaRothia mucilaginosa (SP318) -0.20388553177658 0.416747279549001 -0.489230624365975 0.624678430651 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.143821253861495 0.322801788399432 0.445540449371773 0.655929235050626 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) -0.129041352001804 0.326150164693943 -0.395650120621265 0.692363156940178 1 FALSE MogibacteriumMogibacterium timidum (SP324) -0.367204531653505 0.296421384335679 -1.23879231073851 0.215422422213558 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.441208391286004 0.336770804965811 1.3101147272276 0.190157027029085 1 FALSE GemellaGemella morbillorum (SP332) 0.194912452177208 0.366909828512328 0.531227121844894 0.595261400547308 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.0406288302672118 0.404193695993718 0.100518218542041 0.919932919783524 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.0234795100988812 0.400870010280133 0.0585713809882497 0.953293506198324 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.149600083059047 0.316535309696938 -0.47261736203231 0.636486193405255 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.767053056923937 0.628913443214651 -1.21964805363866 0.222598321589786 1 FALSE NeisseriaNeisseria elongata (SP369) 0.0963825104962072 0.287329954657709 0.335441915936073 0.737291753291371 1 FALSE StreptococcusStreptococcus salivarius (SP374) -0.0707891425400851 0.298862043277054 -0.236862271849161 0.81276363986269 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.20704564135358 0.338658060986489 0.611370775437824 0.540954145487973 1 FALSE PrevotellaPrevotella intermedia (SP41) -0.307486709845674 0.314683469274503 -0.977130163699347 0.328504716305267 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.306615984357772 0.343192483565913 -0.893422784706425 0.371630805472714 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.503295111523285 0.484787541444307 -1.03817666193285 0.299187815820259 1 FALSE NeisseriaNeisseria mucosa (SP44) -0.287387473502749 0.370353019836138 -0.775982530478361 0.437759300721974 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.516797276393763 0.410973923384615 1.25749408171115 0.20857478074696 1 FALSE GemellaGemella moribillum (SP45) -0.169689799176834 0.318039755685462 -0.533549017515459 0.593653589092454 1 FALSE RothiaRothia aeria (SP465) 0.795056435170256 0.390307381700376 2.03700076515742 0.0416499653287455 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.616428698522304 0.506273164962053 1.21758122133238 0.223383154108995 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.214849825847692 0.534256848633282 -0.402147069143453 0.687575793966104 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.415420443613037 0.4774305092878 0.870117086217919 0.384236421152455 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.0734212462705814 0.563139326940653 -0.130378474310175 0.896266996225791 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.228645023472556 0.339372743915888 0.673728304855338 0.500484063228234 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.149664315122661 0.340285602495507 -0.43981971034063 0.660067690849033 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.43720639716026 0.506668182238557 0.862904781643478 0.388189821452606 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.452023583789941 0.462841061366094 0.976628094438671 0.328753305151094 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 0.371238323637882 0.30687091968824 1.20975400345864 0.226373300805808 1 FALSE PrevotellaPrevotella denticola (SP60) -0.489594946531435 0.471171219896695 -1.03910197791533 0.298757311175264 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.0173301981807002 0.445363273856025 0.0389124995212393 0.968960150940684 1 FALSE TreponemaTreponema socranskii (SP63) -0.12903770765225 0.426360263298993 -0.302649469849304 0.762157009903754 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.0565305124648088 0.529187900052865 0.106825028424047 0.914927791275607 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.294873008627721 0.29197772154411 -1.00991612328605 0.312535477262479 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.128244996810823 0.36116778377261 -0.355084264358323 0.722526464762958 1 FALSE CorynebacteriumCorynebacterium durum (SP68) -0.0156152701123211 0.411283324486853 -0.0379671851072588 0.969713845645171 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.518891702681687 0.432644453509824 1.19934902313478 0.230392260458427 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -0.135153970059729 0.377800928869389 -0.357738585937817 0.720538954094069 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.0739916899415186 0.358359671359327 -0.206473260958338 0.836421249403085 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.954991817478606 0.433787645457125 -2.2015191706814 0.0276992910614794 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.173480460182526 0.37075309897129 -0.467913715795966 0.639846294609191 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.185944127786998 0.412277328806137 0.451017106192694 0.651977220099464 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) 0.316456798032569 0.460431621594847 0.687304657608927 0.491890764390219 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.0935345148145438 0.532678359804931 -0.175592856538787 0.860613814811564 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) 0.272402212038472 0.392910356358846 0.693293540447394 0.488125355974663 1 FALSE VeillonellaVeillonella parvula (SP88) 0.482112386665834 0.322795587031036 1.49355321459051 0.135292435597304 1 FALSE PrevotellaPrevotella oulorum (SP9) -0.0100656607331596 0.393266028086495 -0.0255950425775038 0.979580340226292 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.0235924109389636 0.274753470542269 -0.0858675629916529 0.931571697226778 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.753111278524529 0.490021345315588 1.53689484289609 0.124319062611546 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.268644868315484 0.40746754823069 -0.659303715061474 0.509700757258895 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0287546121313549 0.322202472292281 -0.0892439214596424 0.928888060333268 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.0477898570222518 0.327838993789372 -0.145772339250637 0.884101112696214 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 0.0390695214528119 0.447789198944209 0.087249807599043 0.930472949533901 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.158791612219068 0.38832981372973 -0.408909145280264 0.682606337375097 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.411863867085363 0.346777117484977 -1.18769043953198 0.234955391754061 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.637287121613328 0.439896129589976 1.44872182032458 0.147415284259523 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) -0.283417596952642 0.389222606327785 -0.728163247316525 0.466513660928094 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.456334604143964 0.428067824857662 -1.06603341256891 0.286408538127345 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 1.0592136552157 0.444566669702191 2.38257549970008 0.0171920062286144 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.736748269312088 0.447173722991868 1.64756610559043 0.0994417405421947 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.284119435504479 0.466436983045407 0.609127161507303 0.542440155288624 1 FALSE