CompareDUS+OSS 12 Weeks P2...1 CompareDUS+OSS 12 Weeks P2...2 CompareDUS+OSS 12 Weeks P2...3 CompareDUS+OSS 12 Weeks P2...4 CompareDUS+OSS 12 Weeks P2...5 CompareDUS+OSS 12 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Actinomyces sp._HMT_897 (SP1) 0.253524020009631 0.422557473391982 0.599975236444231 0.548522739274828 1 FALSE Leptotrichia buccalis (SP10) -0.309877793090559 0.329071191213064 -0.941674024846259 0.346359557686363 1 FALSE Capnocytophaga endodontalis (SP101) -0.493315185455658 0.436214153477827 -1.13090137383801 0.258096605006681 1 FALSE Prevotella veroralis (SP102) -0.327106607152707 0.371950568334018 -0.879435696570734 0.379165084389122 1 FALSE Filifactor alocis (SP107) -0.443293544842158 0.33784745468475 -1.31211154234032 0.189482502064248 1 FALSE Actinomyces israelii (SP109) 0.948217163332701 0.408159651864719 2.32315261687596 0.0201709551980572 1 FALSE Prevotella pleuritidis (SP11) -0.737886074711529 0.410212677659691 -1.79878905479287 0.0720520553509866 1 FALSE Prevotella oulorum (SP111) -0.123721815480433 0.386116520178321 -0.32042611236446 0.748645333397525 1 FALSE Parvimonas sp._HMT_110 (SP112) 0.443757515125722 0.356976987976195 1.24309837909023 0.213831583034783 1 FALSE Treponema sp._HMT_231 (SP114) -0.0748170072848336 0.352537893516929 -0.212224015235516 0.831932271988571 1 FALSE Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP116) -0.117768607940379 0.314846480272105 -0.374050895657458 0.70836645074475 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP117) -0.962173299231574 0.468049033248548 -2.05571047236974 0.0398104318953335 1 FALSE Prevotella sp._HMT_317 (SP118) -0.442737586893068 0.460885562965666 -0.960623682903362 0.336741416358042 1 FALSE Prevotella loescheii (SP119) 0.102922962070914 0.319397330631384 0.322241146685404 0.747270015021273 1 FALSE Streptococcus oralis (SP12) -0.42507383101659 0.518203246246625 -0.820283998788939 0.412054226062661 1 FALSE Treponema sp._HMT_257 (SP120) 0.0796953230776335 0.270442512416364 0.29468489390062 0.768234603939574 1 FALSE Schaalia sp._HMT_180 (SP121) 0.825718017737239 0.464468442604601 1.77776990209896 0.0754416536396344 1 FALSE Schaalia sp._HMT_178 (SP122) 0.215031264815286 0.310726517347291 0.692027402910551 0.488920120267577 1 FALSE Streptococcus cristatus (SP123) 0.200892755189831 0.488638837731386 0.411127277812218 0.680979209127086 1 FALSE Prevotella salivae (SP124) 0.0415899523048264 0.383228319529525 0.108525258143461 0.913579045735279 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) 0.307879139149556 0.435215771062329 0.707417239035356 0.479307226992131 1 FALSE Selenomonas sp._HMT_134 (SP127) -0.037143968849255 0.340173760741365 -0.10919116385786 0.913050868624472 1 FALSE Prevotella maculosa (SP129) -0.424000159455019 0.363702019908347 -1.16578994959079 0.243699381698948 1 FALSE Selenomonas sputigena (SP13) 0.356127360898492 0.429748121610541 0.828688580566344 0.407280649197619 1 FALSE Lautropia mirabilis (SP131) 0.215145354349152 0.43632274008307 0.493087649541693 0.621950657080265 1 FALSE Porphyromonas endodontalis (SP132) -0.763844523097539 0.433544695803609 -1.76185876679149 0.078093162734287 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP135) -0.33725915751551 0.436864905098511 -0.771998742813776 0.440115172099401 1 FALSE Olsenella sp._HMT_807 (SP136) 0.575517918186634 0.507052366661436 1.13502658902076 0.256364177962971 1 FALSE Actinomyces sp._HMT_525 (SP137) 0.294553789692623 0.330719999154946 0.890644020456174 0.373120175307095 1 FALSE Bacteroidales_[G-2] bacterium_HMT_274 (SP14) -0.0564824661397948 0.411187371140136 -0.137364301785779 0.890742846573517 1 FALSE Capnocytophaga sp._HMT_864 (SP140) -0.146240332963999 0.319142854371977 -0.458228442093046 0.646788327961417 1 FALSE Schaalia odontolytica (SP141) 0.0753387181231411 0.329835078435549 0.228413298186726 0.819324952226246 1 FALSE Streptococcus intermedius (SP147) 0.219184368711403 0.516719584172613 0.424184365031118 0.671431362370716 1 FALSE Campylobacter gracilis (SP151) 0.128762220936388 0.437013519175831 0.294641276039291 0.768267927418135 1 FALSE Actinomyces sp._HMT_448 (SP153) -0.186310119024203 0.588741581768802 -0.316454833145057 0.75165730280748 1 FALSE Streptococcus gordonii (SP155) 0.860904532602688 0.577062671502945 1.49187354357974 0.135732299515383 1 FALSE Peptoanaerobacter [Eubacterium] yurii (SP157) 0.0566836531733731 0.289042242799224 0.196108543251054 0.844525209550423 1 FALSE Selenomonas noxia (SP161) -0.406965075415064 0.424803984156368 -0.958006729205398 0.338059365335091 1 FALSE Selenomonas infelix (SP164) -0.677147183838473 0.245957450809005 -2.7531070175398 0.00590325956736051 0.9268117520756 FALSE Mogibacterium timidum (SP165) -0.439310128777957 0.367043137566353 -1.19688963997737 0.231349572728503 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP166) -0.0195753567852579 0.282683809223671 -0.0692482418395921 0.944792023804954 1 FALSE Leptotrichia hongkongensis (SP167) -0.047308784647706 0.4610664987818 -0.102607291513702 0.918274655597618 1 FALSE Prevotella sp._HMT_314 (SP17) -0.694165039987328 0.322282380156453 -2.15390316917215 0.0312477663873894 1 FALSE Capnocytophaga ochracea (SP172) -0.1398285454311 0.356323577622215 -0.392420132184882 0.694747813220976 1 FALSE Actinomyces oris (SP173) -0.214757998691008 0.470609633448945 -0.456339996946336 0.648145506468951 1 FALSE Mogibacterium vescum (SP174) -0.102470510619795 0.268835618500144 -0.381164189445902 0.703081419614995 1 FALSE Selenomonas sp._HMT_137 (SP177) -0.13325659357843 0.243234103069849 -0.54785324876982 0.583792672331159 1 FALSE Actinomyces naeslundii (SP179) 0.209230700897265 0.440814711650213 0.474645458437625 0.63503969928622 1 FALSE Treponema sp._HMT_237 (SP18) -0.665744160072881 0.347759218265991 -1.91438249543014 0.0555713005276161 1 FALSE Streptococcus anginosus (SP180) -0.199500556589271 0.474076269464889 -0.420819537781244 0.673886863667937 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP183) 0.152777444292407 0.395364478817748 0.386421776557304 0.699184324880013 1 FALSE Oribacterium sp._HMT_078 (SP186) 0.0777523463846987 0.451908244188199 0.172053392219856 0.863395553876955 1 FALSE Actinomyces sp._HMT_171 (SP189) 0.0254370477329819 0.388202555827661 0.0655251938739797 0.947755847625663 1 FALSE Catonella morbi (SP19) -0.351893047217969 0.357882511860131 -0.983264159483424 0.325477444781998 1 FALSE Actinomyces sp._HMT_175 (SP190) -0.441919347116327 0.443055295359216 -0.997436102773655 0.318552874611324 1 FALSE Tannerella forsythia (SP193) -0.25900213208345 0.369266213869504 -0.701396776513596 0.483055433111656 1 FALSE Bergeyella sp._HMT_900 (SP196) -0.184667829424908 0.25102634000519 -0.735651204654817 0.461942992261673 1 FALSE Alloprevotella rava (SP199) 0.0575168887604115 0.322235626816459 0.178493263853697 0.858335610919693 1 FALSE Granulicatella adiacens (SP2) -0.291401642343081 0.499912416377915 -0.582905390617049 0.5599569915496 1 FALSE Streptococcus oralis_subsp._dentisani_clade_058 (SP200) -0.185380723356603 0.30532415145342 -0.60716036538264 0.543744492481349 1 FALSE Absconditabacteria_(SR1)_[G-1] bacterium_HMT_345 (SP201) -0.0178639823464498 0.24895046607795 -0.0717571757461836 0.942795153724594 1 FALSE Peptostreptococcus stomatis (SP208) -0.111457423238647 0.364936924895838 -0.305415581803512 0.760049655808733 1 FALSE Prevotella marshii (SP209) 0.449593513773218 0.28426791772059 1.58158373051133 0.11374463053476 1 FALSE Tannerella sp._HMT_286 (SP212) -0.181020259634747 0.321131019362809 -0.563695964326116 0.572961064385922 1 FALSE Capnocytophaga sputigena (SP216) 0.19627476583022 0.330990686402465 0.592991808813501 0.553186634120084 1 FALSE Ruminococcaceae_[G-1] bacterium_HMT_075 (SP218) -0.14706349271683 0.292311712320513 -0.503105029727916 0.614890430639362 1 FALSE Actinomyces sp._HMT_169 (SP22) 0.353007019908207 0.552547872725482 0.638871376279081 0.522906610257116 1 FALSE Streptococcus constellatus (SP222) 0.293812041728318 0.342483982892223 0.857885496562852 0.390955693536714 1 FALSE Prevotella melaninogenica (SP223) -0.216372351875413 0.373777424973084 -0.578880203615812 0.562670008682912 1 FALSE Lachnoanaerobaculum orale (SP224) 0.319165073831625 0.329311402951679 0.969189256645501 0.332450770354414 1 FALSE Capnocytophaga sp._HMT_336 (SP225) -0.171922107145517 0.329454419679255 -0.521838824663194 0.60178255510732 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_155 (SP229) 0.155673643409837 0.322869812861976 0.482156080278666 0.629695073923181 1 FALSE Kingella oralis (SP232) 1.02313903464808 0.451809245091878 2.26453762458983 0.02354106837911 1 FALSE Arachnia propionica (SP235) 0.499417222381887 0.375321622059405 1.33063802623884 0.183308143959848 1 FALSE Scardovia wiggsiae (SP236) -0.0147718079960749 0.487536384028168 -0.0302988832833889 0.975828687176 1 FALSE Porphyromonas catoniae (SP24) -0.676799258682229 0.268332800679191 -2.52223826893003 0.0116610692170129 1 FALSE Dialister invisus (SP25) 0.299689337883847 0.474488751259854 0.63160472632516 0.527645197424413 1 FALSE Treponema sp._HMT_238 (SP250) -0.14710014042675 0.273664801317433 -0.53751940227097 0.59090888645673 1 FALSE Peptidiphaga sp._HMT_183 (SP251) 0.183807028774637 0.543006765205928 0.33849859808824 0.73498748337096 1 FALSE Cardiobacterium hominis (SP257) 0.0730176557411338 0.318172985815928 0.22949043129443 0.81848775692 1 FALSE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP26) 0.193412462292507 0.496171319925661 0.389809838911054 0.696677167779592 1 FALSE Treponema lecithinolyticum (SP264) -0.08967523012937 0.286039365901184 -0.313506603704154 0.753895804366755 1 FALSE Mycoplasma faucium (SP271) -0.180638233101287 0.260834360339931 -0.692540019903325 0.488598262659546 1 FALSE Ruminococcaceae_[G-2] bacterium_HMT_085 (SP275) -0.220999209015873 0.302883171889954 -0.729651659538776 0.465603136457894 1 FALSE Peptidiphaga gingivicola (SP286) -0.212593638589102 0.302263764258925 -0.703338156031797 0.481845037387168 1 FALSE Leptotrichia sp._HMT_417 (SP288) 0.0574546662286991 0.299879139735412 0.191592740593401 0.848061229337886 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP292) 0.395455951372256 0.470820069458311 0.839930107115519 0.400947575746428 1 FALSE Neisseria elongata (SP295) 0.0731343000162454 0.282552226595125 0.258834626424803 0.795762840007082 1 FALSE Mogibacterium neglectum (SP298) 0.193752974621437 0.313629190637263 0.617777236320863 0.536722190861663 1 FALSE Stomatobaculum longum (SP3) 0.0411105750908925 0.434196747506659 0.0946819047516288 0.924567491315403 1 FALSE Tannerella sp._HMT_808 (SP30) 0.298477654925748 0.34540608979592 0.864135473413629 0.387513474065021 1 FALSE Porphyromonas pasteri (SP31) 0.0257231751410644 0.398669931040815 0.064522486242964 0.948554202981759 1 FALSE Bulleidia extructa (SP316) -0.480111046276645 0.246283727810913 -1.9494225239487 0.0512449868385165 1 FALSE Neisseria sicca (SP318) -0.214966289500581 0.305024969621916 -0.704749810374657 0.480965947433561 1 FALSE Prevotella oris (SP32) -0.0242394129388954 0.492572381815139 -0.0492098498287148 0.960752061750006 1 FALSE Megasphaera micronuciformis (SP320) -0.018914964891595 0.334011880793459 -0.0566296170263814 0.954840241419581 1 FALSE Shuttleworthia satelles (SP326) 0.2516350667333 0.333645310534661 0.754199321219467 0.450729545134458 1 FALSE Prevotella buccae (SP329) 0.24010233529438 0.304309950503463 0.789005863584627 0.430108579458253 1 FALSE Actinomyces dentalis (SP346) 0.84750422254314 0.448895717583768 1.88797573544459 0.0590292080003002 1 FALSE Gemella haemolysans (SP354) -0.0969170141846262 0.402534475478821 -0.240766990378506 0.809735714956609 1 FALSE Cardiobacterium valvarum (SP356) -0.245355122511087 0.242963465419983 -1.00984369023124 0.312570184307317 1 FALSE Alloprevotella tannerae (SP36) -0.386766551378027 0.461735955362747 -0.837635767555023 0.402235298309639 1 FALSE Streptococcus parasanguinis_clade_411 (SP37) -0.352933646460959 0.549040711830181 -0.642818717913439 0.520341736074153 1 FALSE Solobacterium moorei (SP371) 0.190647305382119 0.373310909382692 0.510693099479396 0.60956597340699 1 FALSE Mycoplasma salivarium (SP381) 0.336141314499817 0.25274663813555 1.32995365231937 0.183533542378654 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_150 (SP382) -0.0388961897661591 0.321795220939279 -0.120872490438566 0.903792031831293 1 FALSE Streptococcus mutans (SP4) -0.0809548794131343 0.599728945663051 -0.134985779823637 0.892623117479884 1 FALSE Prevotella oralis (SP405) 0.0991042175225547 0.31980243366589 0.309892005468891 0.756643082464309 1 FALSE Lancefieldella rimae (SP42) 0.48333447943045 0.499126833272718 0.968360038392006 0.33286458985112 1 FALSE Fusobacterium nucleatum (SP43) -0.149350687808863 0.352416297368591 -0.423790525364546 0.671718588511953 1 FALSE Campylobacter concisus (SP44) -0.624122118208687 0.300297526686124 -2.0783458495182 0.0376775163532076 1 FALSE Capnocytophaga sp._HMT_380 (SP45) 0.113801175429418 0.322479788678726 0.352893977931725 0.724167925678137 1 FALSE Campylobacter showae (SP46) -0.293404148549239 0.353245173240307 -0.830596341509361 0.406201702196269 1 FALSE Peptococcus sp._HMT_167 (SP47) -0.129070872001311 0.272021992495958 -0.474486900184108 0.635152737300663 1 FALSE Eikenella corrodens (SP48) 0.319423235149472 0.349487192430407 0.91397694126682 0.360728962171413 1 FALSE Actinomyces sp._HMT_170 (SP49) 0.298010156844028 0.386395297099642 0.771257204942581 0.440554492947363 1 FALSE Schaalia meyeri (SP51) 0.381643094910747 0.337922741173733 1.12937973213983 0.258737679032358 1 FALSE Veillonella parvula (SP52) 0.0247628450370916 0.521109676052691 0.0475194496956294 0.962099229229588 1 FALSE Streptococcus mitis (SP57) -0.161099463761689 0.501620160428231 -0.321158271677437 0.748090452804417 1 FALSE Fusobacterium nucleatum_subsp._vincentii (SP58) 0.052118323784606 0.39466879326224 0.132055852082472 0.894940114948459 1 FALSE Prevotella denticola (SP59) 0.754755755429331 0.502159940183412 1.50301865010112 0.132834234740549 1 FALSE Corynebacterium matruchotii (SP6) 0.9261446581261 0.510366530566949 1.81466574051648 0.0695752929844507 1 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP60) 0.183102353757635 0.353106336388847 0.518547346474121 0.604076434991389 1 FALSE Rothia aeria (SP61) 0.670143418624477 0.375476353102706 1.78478195254328 0.0742966918150715 1 FALSE Leptotrichia sp._HMT_215 (SP62) 0.0830160833563416 0.322899277429489 0.257095909341171 0.797104735314406 1 FALSE Haemophilus parainfluenzae (SP63) 0.340134244423969 0.538118951430525 0.632080032713516 0.527334581906785 1 FALSE Prevotella multiformis (SP64) -0.331962013294722 0.28911291381699 -1.14820887421465 0.250882346694501 1 FALSE Fretibacterium fastidiosum (SP65) -0.895966252191944 0.302621714709355 -2.9606806406885 0.0030696005253724 0.488066483534212 FALSE Rothia dentocariosa (SP66) 0.955943631944615 0.577168748645969 1.65626367364353 0.0976684335727187 1 FALSE Lachnoanaerobaculum saburreum (SP67) 0.0432263452437851 0.453936160644651 0.0952256043722049 0.924135633046275 1 FALSE Aggregatibacter sp._HMT_458 (SP68) 0.215402901974891 0.382186566416448 0.563606680356675 0.573021839427162 1 FALSE Prevotella sp._HMT_300 (SP69) -0.242404880808303 0.40440011528941 -0.599418426562084 0.54889389226543 1 FALSE Streptococcus sanguinis (SP7) 1.64754551019651 0.56159164968615 2.933707278442 0.00334939927256819 0.529205085065773 FALSE Bergeyella sp._HMT_322 (SP70) -0.0856514315700729 0.382104992223841 -0.224156798034969 0.822635298279047 1 FALSE Treponema socranskii (SP72) 0.204163579622739 0.439216803165328 0.464835539422405 0.642049235038883 1 FALSE Prevotella intermedia (SP73) -0.530240710949129 0.363275986403939 -1.45960848168901 0.144397706871227 1 FALSE Leptotrichia hofstadii (SP74) -0.142601755124677 0.289287505724679 -0.492941286100319 0.62205407413283 1 FALSE Gemella morbillorum (SP77) -0.226858234927801 0.421421800597825 -0.53831632489345 0.590358682850606 1 FALSE Anaeroglobus geminatus (SP79) 0.578581031210312 0.370024233930103 1.56363010353426 0.117904461033951 1 FALSE Capnocytophaga granulosa (SP8) -0.227222424285495 0.382649563006601 -0.593813364113461 0.552636949571656 1 FALSE Veillonella atypica (SP80) -0.259435379397803 0.311821114390615 -0.83200068059795 0.405408560343949 1 FALSE Bacteroidetes_[G-5] bacterium_HMT_511 (SP81) -0.208796000113587 0.308597698029003 -0.676596103753062 0.498662251864846 1 FALSE Capnocytophaga gingivalis (SP82) -1.00979813093984 0.388833187955478 -2.59699573549639 0.00940430916587875 1 FALSE Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP83) 0.0317516426998971 0.338143481448654 0.0938999106647525 0.925188664804499 1 FALSE Treponema denticola (SP84) -0.45546267162211 0.319721278977313 -1.424561646566 0.154283953300468 1 FALSE Leptotrichia wadei (SP85) -0.118531088473043 0.494628265339761 -0.239636706550976 0.810611906030617 1 FALSE Porphyromonas gingivalis (SP86) 0.122888484894779 0.295162383086266 0.416341959330442 0.67715979302827 1 FALSE Streptococcus salivarius (SP87) 0.453147360136205 0.468421676421744 0.967391952477053 0.333348131529252 1 FALSE Streptococcus sp._HMT_064 (SP9) 0.115948711617232 0.465314207838616 0.249183690641672 0.803218694588175 1 FALSE Capnocytophaga leadbetteri (SP92) -0.460480476208666 0.384097873063045 -1.19886234343475 0.230581476159229 1 FALSE Parvimonas micra (SP93) 0.057219876340074 0.476204175217055 0.120158283605962 0.904357763141796 1 FALSE Colibacter massiliensis (SP94) 0.325756752924154 0.3378935723488 0.964080940219494 0.335005347610958 1 FALSE Corynebacterium durum (SP96) 0.193359386622604 0.356783174617608 0.541952088491397 0.587851512081487 1 FALSE Lancefieldella parvula (SP97) 0.468869734768739 0.494899908229032 0.947403155612939 0.343433383749203 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) 0.458227649104544 0.437145570456847 1.04822667795916 0.294534181977856 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.0166245112498585 0.373979874208027 0.0444529569540714 0.964543349791876 1 FALSE Fusobacterium nucleatum_nov_97.018% (SPN283) -0.0153603310345932 0.286403999695981 -0.0536316917742008 0.957228606455099 1 FALSE Prevotella veroralis_nov_96.402% (SPN608) -0.446119145141875 0.267802745988742 -1.66584977870476 0.0957433385682338 1 FALSE Veillonella dispar_parvula (SPP13) -0.285480331820197 0.403948498119315 -0.706724577883872 0.479737652780073 1 FALSE