SubgroupSmoker 12 Weeks P1...1 SubgroupSmoker 12 Weeks P1...2 SubgroupSmoker 12 Weeks P1...3 SubgroupSmoker 12 Weeks P1...4 SubgroupSmoker 12 Weeks P1...5 SubgroupSmoker 12 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Actinomyces sp._HMT_897 (SP1) -0.562923717547258 0.639411486258786 -0.880377862526275 0.378654644898305 1 FALSE Capnocytophaga endodontalis (SP101) -1.59305433018973 0.664232953333714 -2.39833679162463 0.0164697142314028 1 FALSE Prevotella veroralis (SP102) -0.824829801403961 0.60655590403633 -1.35985783983822 0.173874914766691 1 FALSE Selenomonas artemidis (SP103) -0.00116636636904199 0.24920610745372 -0.00468032818681459 0 0 TRUE Filifactor alocis (SP107) 0.265032522455091 0.30061474081772 0.881635151137833 0 0 TRUE Actinomyces israelii (SP109) 0.973421350904971 0.397041246373833 2.45168823087073 0 0 TRUE Prevotella pleuritidis (SP11) 0.496305737749779 0.443979554020136 1.11785719242213 0.263627990360636 1 FALSE Prevotella oulorum (SP111) -0.468405531728163 0.655319304535602 -0.714774505323176 0.474748391127164 1 FALSE Parvimonas sp._HMT_110 (SP112) 0.686084735345017 0.341854812572378 2.00694771614414 0 0 TRUE Treponema sp._HMT_231 (SP114) -0.403989296320019 0.389427312084103 -1.03739333062693 0.299552585277621 1 FALSE Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP116) -0.922001713908854 0.498840665488776 -1.84828899826251 0.0645605464310996 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP117) -0.12059859317343 0.580668852141619 -0.207689103227492 0.835471726528019 1 FALSE Prevotella sp._HMT_317 (SP118) -0.390316616353945 0.621726722548225 -0.627794499091472 0.530138570169212 1 FALSE Prevotella loescheii (SP119) -0.235653686366137 0.507874008015839 -0.464000288746393 0.642647538757501 1 FALSE Streptococcus oralis (SP12) 0.660900120431391 0.893934324407379 0.73931619179018 0.459715019459502 1 FALSE Schaalia sp._HMT_180 (SP121) -2.29403767860181 0.751633613997797 -3.05206903453966 0.0022726982531693 0.32499585020321 FALSE Schaalia sp._HMT_178 (SP122) -0.0559401906480357 0.455421192425003 -0.122831768873487 0.902240316818623 1 FALSE Streptococcus cristatus (SP123) -2.23644802112348 0.75876802019107 -2.94747269469831 0.00320383045547364 0.44853626376631 FALSE Prevotella salivae (SP124) 0.192608369161353 0.306509448596201 0.628392925710743 0 0 TRUE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) 0.0168271106743161 0.479846962294857 0.0350676611431295 0.972025788213106 1 FALSE Erysipelotrichaceae_[G-1] bacterium_HMT_905 (SP128) -0.453929509950641 0.324793247387719 -1.39759528131066 0.162234636157785 1 FALSE Prevotella maculosa (SP129) -0.455100209683461 0.386366989511989 -1.17789620241182 0.238837989243931 1 FALSE Selenomonas sputigena (SP13) 0.45284820022468 0.564093477279412 0.802789286642239 0.42209653542948 1 FALSE Lautropia mirabilis (SP131) -1.20405434385725 0.84997050276469 -1.41658368136404 0.156604682373823 1 FALSE Porphyromonas endodontalis (SP132) 0.850542605293273 0.509346025831586 1.66987187915058 0.0949447151485388 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP135) -0.804022830153758 0.620638087665045 -1.29547774481363 0.195155473825042 1 FALSE Olsenella sp._HMT_807 (SP136) -0.697205573403784 0.767028800105428 -0.908969224242888 0.363366371202555 1 FALSE Actinomyces sp._HMT_525 (SP137) -0.359727696400457 0.654961666081576 -0.549234733923578 0.582844370599096 1 FALSE Bacteroidales_[G-2] bacterium_HMT_274 (SP14) 0.218119770463354 0.467066404562114 0.466999485154249 0.640500246420894 1 FALSE Capnocytophaga sp._HMT_864 (SP140) -0.942748960536276 0.612159850023954 -1.54003723128752 0.123551278368545 1 FALSE Schaalia odontolytica (SP141) -0.513612015688071 0.498960770071954 -1.02936352213422 0.303308883744944 1 FALSE Actinomyces viscosus (SP146) -0.36629405765588 0.424355994439375 -0.863176348291716 0.388040515626146 1 FALSE Streptococcus intermedius (SP147) -0.00131188800273174 0.788281056200198 -0.00166423890617836 0.998672130084238 1 FALSE Campylobacter gracilis (SP151) 0.214797445557153 0.672927445702702 0.319198521220741 0.749575978254462 1 FALSE Aggregatibacter aphrophilus (SP152) -0.243715464158354 0.545473507345097 -0.446796152107468 0.655022249823776 1 FALSE Actinomyces sp._HMT_448 (SP153) -1.16467167745668 1.09952462404414 -1.05925019957526 0.289485848542416 1 FALSE Streptococcus gordonii (SP155) -1.30001532519418 0.878716694160133 -1.47944762382911 0.139020719896383 1 FALSE Selenomonas noxia (SP161) -1.28086432833905 0.746900294480513 -1.71490671218696 0.0863623318399983 1 FALSE Mogibacterium timidum (SP165) -0.113340884488358 0.462870294805731 -0.244865323526383 0.806560712241551 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP166) 0.0624885721370702 0.417280637859457 0.149751909069207 0.880960352388297 1 FALSE Leptotrichia hongkongensis (SP167) -1.27010120611986 0.760205384566028 -1.670734293529 0.0947741719931849 1 FALSE Actinomyces oris (SP173) -0.979425150478527 0.780452739192001 -1.25494485610048 0.209498778866766 1 FALSE Actinomyces naeslundii (SP179) -0.793584295770935 0.708917345500364 -1.11943134246604 0.262956166008439 1 FALSE Treponema sp._HMT_237 (SP18) 0.102031057411321 0.433168046445677 0.235546130995875 0.813784878484167 1 FALSE Streptococcus anginosus (SP180) 0.0500703188057275 0.706784982349617 0.0708423637402073 0.943523215113671 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP183) -0.68915466149679 0.637323322193687 -1.08132660064078 0.279551858788691 1 FALSE Oribacterium sp._HMT_078 (SP186) -0.0349692890336317 0.642852978998169 -0.0543970241658184 0.956618849718058 1 FALSE Actinomyces sp._HMT_171 (SP189) -0.466985007609779 0.646114176974212 -0.722759264928523 0.469827797785557 1 FALSE Catonella morbi (SP19) 0.290302459997659 0.473755479365896 0.612768553909324 0.540029386261005 1 FALSE Actinomyces sp._HMT_175 (SP190) 0.735404006225863 0.609811120939033 1.20595374694616 0.227835325130757 1 FALSE Tannerella forsythia (SP193) 0.254099878630381 0.30707965183548 0.827472211563263 0 0 TRUE Alloprevotella rava (SP199) 0.0262468378308502 0.407272653412291 0.0644453724328013 0.948615603111194 1 FALSE Granulicatella adiacens (SP2) -1.64668133495929 0.736960340107013 -2.23442327265559 0.0254552358289306 1 FALSE Streptococcus oralis_subsp._dentisani_clade_058 (SP200) -1.18959894564583 0.645463033349278 -1.84301638387106 0.0653266183964029 1 FALSE Peptostreptococcus stomatis (SP208) -0.639586331676561 0.523161583076099 -1.2225407070525 0.221503219827133 1 FALSE Capnocytophaga sputigena (SP216) -0.96925430284809 0.626871518213854 -1.54617696718745 0.122061834533694 1 FALSE Actinomyces sp._HMT_169 (SP22) -0.396515352641342 0.977747013744977 -0.405539824788219 0.685080751007627 1 FALSE Streptococcus constellatus (SP222) 0.152092492794479 0.293173895880739 0.51877911004856 0 0 TRUE Prevotella melaninogenica (SP223) 0.0535198658983318 0.461293037417941 0.11602140409035 0.907635578339055 1 FALSE Lachnoanaerobaculum orale (SP224) -0.84289545974001 0.49168686658275 -1.71429321592049 0.0864748884548211 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_155 (SP229) 0.148794481172497 0.272878453223232 0.545277501447774 0 0 TRUE Kingella oralis (SP232) -2.06702142603346 0.698862289897157 -2.95769489342119 0.00309948743990441 0.437027729026522 FALSE Arachnia propionica (SP235) -0.357269056213804 0.461373726539775 -0.774359343981854 0.43871831894997 1 FALSE Scardovia wiggsiae (SP236) 0.237926646175418 0.593393877992178 0.400959050977191 0.68845027268525 1 FALSE Alloprevotella sp._HMT_473 (SP238) -0.411588143511442 0.502287054196243 -0.819428133918489 0.412542188853486 1 FALSE Dialister invisus (SP25) -0.051283977947939 0.616271971290204 -0.0832164698981407 0.933679417076844 1 FALSE Actinomyces massiliensis (SP253) 0.125467032724427 0.289851421901109 0.432866714613645 0 0 TRUE Cardiobacterium hominis (SP257) -0.644664365408938 0.609823881439363 -1.05713204259456 0.290451329217492 1 FALSE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP26) -1.01823511320216 0.774890831929614 -1.31403685686483 0.188833801353997 1 FALSE Fretibacterium sp._HMT_360 (SP260) -0.45335992837646 0.438765031976217 -1.03326358149944 0.301480565337337 1 FALSE Treponema lecithinolyticum (SP264) -0.00195903813009346 0.271918776160514 -0.00720449745234598 0 0 TRUE Alloprevotella sp._HMT_912 (SP269) -0.0477744269985321 0.281358918443954 -0.169798872069693 0 0 TRUE Mycoplasma faucium (SP271) -0.132122947577738 0.329540667623387 -0.400930630293962 0.688471197744073 1 FALSE Peptidiphaga gingivicola (SP286) -0.157155414146033 0.558012861836375 -0.281634035511022 0.778224139586913 1 FALSE Leptotrichia sp._HMT_417 (SP288) -0.898486961780616 0.560330442745565 -1.60349481883961 0.108825452107151 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP292) 0.819184714856426 0.572933819423573 1.42980687661379 0.152772454897013 1 FALSE Neisseria elongata (SP295) -0.21165483473634 0.485372923943462 -0.436066422940794 0.662788537781498 1 FALSE Fusobacterium periodonticum (SP296) -1.28735036171622 0.593081972142636 -2.17061118392351 0.0299605759634148 1 FALSE Mogibacterium neglectum (SP298) -0.417877662871556 0.474919774866091 -0.879891057367281 0.378918329650769 1 FALSE Stomatobaculum longum (SP3) 0.515910765431783 0.334764269660349 1.54111657721185 0 0 TRUE Tannerella sp._HMT_808 (SP30) -0.0709186035819648 0.255401031141929 -0.277675478696695 0 0 TRUE Porphyromonas pasteri (SP31) -0.897374581912225 0.647124190646119 -1.38671153834667 0.165529740795125 1 FALSE Neisseria sicca (SP318) -1.6695228648326 0.694709589228443 -2.40319536496797 0.0162525020708151 1 FALSE Prevotella oris (SP32) -0.0829520086942362 0.729903805172513 -0.113647864425958 0.909516942797424 1 FALSE Megasphaera micronuciformis (SP320) 0.278967492043372 0.299571082800639 0.93122303206088 0 0 TRUE Shuttleworthia satelles (SP326) -0.0254198945732055 0.272163602756797 -0.0933993168657475 0 0 TRUE Streptococcus sp._HMT_056 (SP332) -0.585948189667781 0.452848679156527 -1.29391608419652 0.195694408139585 1 FALSE Actinomyces dentalis (SP346) -0.903374462089362 0.795041284097775 -1.13626107242283 0.255847317430888 1 FALSE Cryptobacterium curtum (SP349) -0.0751590102030008 0.268826710135794 -0.279581631471944 0 0 TRUE Peptostreptococcaceae_[XI][G-6] [Eubacterium]_nodatum (SP351) 0.0900309417335667 0.276585955458912 0.32550800196701 0 0 TRUE Gemella haemolysans (SP354) -1.56027809994329 0.640327003726731 -2.43668952092041 0.0148223999156446 1 FALSE Alloprevotella tannerae (SP36) -0.127110342130282 0.600516163879445 -0.211668477512954 0.832365682153859 1 FALSE Streptococcus parasanguinis_clade_411 (SP37) -1.72790365708251 0.943483820251784 -1.83140783126666 0.0670396932923349 1 FALSE Fusobacterium sp._HMT_204 (SP375) -0.0166552843910606 0.277215052995923 -0.0600807359162618 0 0 TRUE Streptococcus mutans (SP4) -2.82748593241633 1.08941531121199 -2.59541600280129 0.00944764924051128 1 FALSE Prevotella oralis (SP405) -0.524143296091605 0.451896526845322 -1.15987458401293 0.246099872030267 1 FALSE Rothia mucilaginosa (SP41) -1.09965349700087 0.811532610155371 -1.35503303655331 0.175407031660485 1 FALSE Lancefieldella rimae (SP42) 0.974600394798974 0.519999591892431 1.87423299939932 0.0608983176605676 1 FALSE Fusobacterium nucleatum (SP43) 2.92149545120983 0.807223477024707 3.61919039071804 0.00029552615621073 0.0428512926505559 TRUE Campylobacter concisus (SP44) -1.01245737717471 0.612952112667211 -1.65177239176007 0.0985809587872277 1 FALSE Campylobacter showae (SP46) 0.0156593423692726 0.444778828492117 0.0352070318237958 0.971914655124339 1 FALSE Peptococcus sp._HMT_167 (SP47) 0.273710002218904 0.403340802040922 0.678607274131254 0.497386732600192 1 FALSE Eikenella corrodens (SP48) -0.000478131197260812 0.426658999468791 -0.00112064013147761 0.999105858728027 1 FALSE Actinomyces sp._HMT_170 (SP49) -0.103144408461205 0.495892939875161 -0.207997332019229 0.835231050540317 1 FALSE Schaalia meyeri (SP51) -0.618173075735687 0.552807810592431 -1.11824229667306 0.263463524154953 1 FALSE Veillonella parvula (SP52) -1.23698229041177 0.818289164350759 -1.5116689115555 0.130618111185863 1 FALSE Streptococcus mitis (SP57) -0.67857510836559 0.886274313019845 -0.765649075457743 0.443885135470193 1 FALSE Fusobacterium nucleatum_subsp._vincentii (SP58) 0.419280012234027 0.351330496694182 1.1934062547351 0 0 TRUE Prevotella denticola (SP59) 0.8629579767588 0.741026018828036 1.16454477283214 0.244203309977901 1 FALSE Corynebacterium matruchotii (SP6) -2.53419325594404 0.810019260057195 -3.1285592589059 0.00175665584994138 0.252958442391559 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP60) -0.142454043340876 0.494222206011527 -0.288238856142278 0.773163907398458 1 FALSE Rothia aeria (SP61) -1.44694255269748 0.750991101872017 -1.92671064822292 0.0540157001017424 1 FALSE Leptotrichia sp._HMT_215 (SP62) -0.32633584358951 0.441341839522437 -0.739417418349975 0.459653568577939 1 FALSE Haemophilus parainfluenzae (SP63) -0.840565158511807 0.889403739133613 -0.94508840195637 0.344613745968751 1 FALSE Fretibacterium fastidiosum (SP65) -0.581069103822944 0.549550151309902 -1.05735409668783 0.290350012826052 1 FALSE Rothia dentocariosa (SP66) -0.96351108192396 0.796577480619997 -1.2095635457508 0.226446413472916 1 FALSE Lachnoanaerobaculum saburreum (SP67) 0.399478589298853 0.505252075438734 0.790652050171129 0.429147064187937 1 FALSE Aggregatibacter sp._HMT_458 (SP68) -0.781901218758864 0.533352399288407 -1.46601237718639 0.142644914958394 1 FALSE Prevotella sp._HMT_300 (SP69) 0.66134067842001 0.320426492442551 2.06393882534098 0 0 TRUE Streptococcus sanguinis (SP7) -1.35848898820611 0.929645539961279 -1.46129780632594 0.143933731628748 1 FALSE Bergeyella sp._HMT_322 (SP70) -0.548652661800711 0.620192141686495 -0.884649489928643 0.376345705777118 1 FALSE Treponema socranskii (SP72) 0.0814171134775944 0.596785342703749 0.136426127874945 0.891484419716976 1 FALSE Prevotella intermedia (SP73) 0.435741892784497 0.342927278183131 1.27065392724985 0 0 TRUE Gemella morbillorum (SP77) 0.21139547646708 0.485172789997005 0.435711731625314 0.663045892890079 1 FALSE Anaeroglobus geminatus (SP79) 0.530647340903893 0.321484171870848 1.65061731598118 0 0 TRUE Veillonella atypica (SP80) -0.355579505601365 0.53132648839649 -0.66922977372064 0.503348916294899 1 FALSE Bacteroidetes_[G-5] bacterium_HMT_511 (SP81) -0.0295134173994819 0.271022060430444 -0.108896734651814 0 0 TRUE Capnocytophaga gingivalis (SP82) -0.603641689995857 0.656023728405694 -0.920152219894333 0.357493218852356 1 FALSE Treponema denticola (SP84) 0.340131605915591 0.313816409170605 1.08385538797839 0 0 TRUE Leptotrichia wadei (SP85) -0.39829150692835 0.727473768403924 -0.547499475894782 0.584035630444661 1 FALSE Streptococcus salivarius (SP87) -2.93432890041581 0.975551448248474 -3.00786688973111 0.00263088344331762 0.373585448951102 FALSE Streptococcus sp._HMT_064 (SP9) -0.338922821933328 0.492861060656938 -0.687664027427072 0.491664377989667 1 FALSE Treponema sp._HMT_262 (SP91) 0.0473730571978073 0.276720772187845 0.171194438434312 0 0 TRUE Capnocytophaga leadbetteri (SP92) -0.25674009440864 0.583813324802893 -0.439764019595341 0.660108029665185 1 FALSE Parvimonas micra (SP93) 0.521259469078492 0.731955510164849 0.712146382996824 0.47637413462817 1 FALSE Corynebacterium durum (SP96) -1.15434981553926 0.69074120498039 -1.67117555347235 0.0946870074506246 1 FALSE Lancefieldella parvula (SP97) -1.19398536440789 0.776586977031921 -1.53747796411839 0.124176307202392 1 FALSE Actinomyces naeslundii_nov_97.422% (SPN109) -0.820697332270371 0.728406417917874 -1.1267025002557 0.259868284985244 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) -2.02251254192247 0.824759882324074 -2.45224408372443 0.0141968324817322 1 FALSE Streptococcus sanguinis_nov_97.727% (SPN14) -0.116219128995616 0.346359741202036 -0.335544565867497 0.737214332507886 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.260079423729696 0.480061427653264 0.541762801067085 0.587981920411053 1 FALSE Actinomyces viscosus_nov_95.841% (SPN468) 0.0517892463774677 0.281678230886802 0.183859598288518 0 0 TRUE Prevotella veroralis_nov_96.402% (SPN608) -0.051273060669195 0.274215207861058 -0.186981098054833 0 0 TRUE Veillonella dispar_parvula (SPP13) -0.445181712742195 0.886971203783975 -0.501912250186896 0.615729247791858 1 FALSE Streptococcus infantis_infantis_clade_638 (SPP16) -1.5194521551981 0.675712537802863 -2.24866651155938 0.024533721317856 1 FALSE