SubgroupSmoker 24 Weeks P1...1 SubgroupSmoker 24 Weeks P1...2 SubgroupSmoker 24 Weeks P1...3 SubgroupSmoker 24 Weeks P1...4 SubgroupSmoker 24 Weeks P1...5 SubgroupSmoker 24 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Actinomyces sp._HMT_897 (SP1) 0.269981330049213 0.561321066266594 0.480974875653408 0.630534355292958 1 FALSE Capnocytophaga endodontalis (SP101) -2.6271642011847 0.782279231442735 -3.3583458381472 0.000784104444774807 0.133297755611717 FALSE Prevotella veroralis (SP102) -0.213760872630864 0.448837479940245 -0.476254506774529 0.633893071665976 1 FALSE Selenomonas artemidis (SP103) -0.551812019530629 0.59769276515973 -0.923236906478465 0.355883759667541 1 FALSE Filifactor alocis (SP107) -0.403306961758914 0.575936523750758 -0.700262867741738 0.483763156578086 1 FALSE Actinomyces israelii (SP109) 0.405747030914055 0.711555390348427 0.570225503759269 0.568524760308274 1 FALSE Prevotella pleuritidis (SP11) 0.0119650172180657 0.638070921812863 0.018751860975064 0.98503905643862 1 FALSE Prevotella oulorum (SP111) -1.34961681740686 0.687151790055547 -1.96407378535354 0.0495215357752159 1 FALSE Parvimonas sp._HMT_110 (SP112) 0.144671573821044 0.488111963427926 0.29639014132135 0.766932153375052 1 FALSE Treponema sp._HMT_231 (SP114) -0.316830066274308 0.602817602188006 -0.525581975583214 0.599178682813607 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP117) -0.285494760600115 0.721685060139641 -0.395594666383801 0.692404072410481 1 FALSE Prevotella sp._HMT_317 (SP118) -0.218246813077612 0.643785274286039 -0.339005599840178 0.734605511639414 1 FALSE Prevotella loescheii (SP119) -0.158499021531194 0.527051613670772 -0.300727703739091 0.763622141577447 1 FALSE Streptococcus oralis (SP12) -0.45512263070063 0.832144521003941 -0.546927389669703 0.584428617663954 1 FALSE Treponema sp._HMT_257 (SP120) -0.661606782615385 0.50963785864681 -1.29819002138515 0.194222046207989 1 FALSE Schaalia sp._HMT_180 (SP121) 0.867486290637515 0.364357211782361 2.3808676282101 0 0 TRUE Schaalia sp._HMT_178 (SP122) -0.276219196052947 0.450450755767856 -0.613206199603536 0.539740006017134 1 FALSE Streptococcus cristatus (SP123) -1.5888009259097 0.683398287314757 -2.32485353768224 0.0200797931144747 1 FALSE Prevotella salivae (SP124) -0.6098411605176 0.55116858203279 -1.10645123905361 0.268531258137198 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) 0.981875291390061 0.517805726328734 1.89622331593666 0.0579305213239145 1 FALSE Prevotella maculosa (SP129) -0.407892780855238 0.49130373399805 -0.830225281489225 0.406411423896855 1 FALSE Selenomonas sputigena (SP13) -0.642095220068795 0.773606123531055 -0.830002763083118 0.406537221441226 1 FALSE Lautropia mirabilis (SP131) 0.0678894233586331 0.779107499581097 0.0871374276272982 0.930562275571302 1 FALSE Porphyromonas endodontalis (SP132) 0.0400863353210832 0.696206394683416 0.0575782348843715 0.954084586950895 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP135) -0.133405311299601 0.640944809016719 -0.208138531466164 0.835120802149042 1 FALSE Olsenella sp._HMT_807 (SP136) 1.06847046058027 0.832893468593822 1.2828416848846 0.199547546677164 1 FALSE Actinomyces sp._HMT_525 (SP137) 1.12824613040719 0.343885638484987 3.28087597777495 0 0 TRUE Bacteroidales_[G-2] bacterium_HMT_274 (SP14) -0.0364048915337146 0.737741054465483 -0.0493464357356269 0.960643214203179 1 FALSE Capnocytophaga sp._HMT_864 (SP140) -2.15696669729698 0.692058147269709 -3.11674200470957 0.00182861524795194 0.307207361655927 FALSE Schaalia odontolytica (SP141) -0.4293083289058 0.619077258296745 -0.69346486751419 0.488017866203888 1 FALSE Actinomyces sp._HMT_896 (SP145) -0.790708225236618 0.647481320833027 -1.2212062337479 0.222007944591528 1 FALSE Actinomyces viscosus (SP146) -0.123131907348715 0.549711643125027 -0.223993631731591 0.822762258490554 1 FALSE Streptococcus intermedius (SP147) -0.188863063850023 0.793863445929178 -0.23790371608428 0.81195577323657 1 FALSE Campylobacter gracilis (SP151) -0.691438895226565 0.705574672177589 -0.979965583362853 0.327103107647247 1 FALSE Aggregatibacter aphrophilus (SP152) -0.742510816519782 0.501433073738755 -1.48077750632506 0.138665872438563 1 FALSE Actinomyces sp._HMT_448 (SP153) -1.1687860499915 1.30260173180956 -0.897270456080102 0.369574617300245 1 FALSE Streptococcus gordonii (SP155) -0.452073209128834 0.977420181959671 -0.462516753258003 0.643710791069086 1 FALSE Peptoanaerobacter [Eubacterium] yurii (SP157) -0.464659471885025 0.503097541869337 -0.923597181887454 0.355696081636885 1 FALSE Selenomonas sp._HMT_138 (SP159) 0.0799452091635766 0.242217765167927 0.330055101896228 0 0 TRUE Selenomonas noxia (SP161) -1.68549184449021 0.812692813142141 -2.07395933276872 0.0380830878803778 1 FALSE Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP162) -0.192686948686747 0.449278693411096 -0.42888067365001 0.668010065434046 1 FALSE Selenomonas infelix (SP164) -0.421149853102211 0.396574237957745 -1.06196977209368 0.28824940812489 1 FALSE Mogibacterium timidum (SP165) 0.487513079152486 0.372374866460203 1.30919974214906 0.190466699561982 1 FALSE Leptotrichia hongkongensis (SP167) -1.95924346250143 0.911020187887871 -2.15060378304435 0.0315074864816082 1 FALSE Prevotella sp._HMT_314 (SP17) -0.576438588687297 0.526636142907016 -1.09456708668982 0.273706341559958 1 FALSE Actinomyces oris (SP173) -0.29590721894579 0.900015891931631 -0.328779993329572 0.742321986172913 1 FALSE Actinomyces naeslundii (SP179) -0.410048763888748 0.755226479100754 -0.542948076154576 0.587165553366679 1 FALSE Treponema sp._HMT_237 (SP18) -0.584311526902228 0.58379629211752 -1.00088255919345 0.316883589361545 1 FALSE Streptococcus anginosus (SP180) -0.22484896258539 0.819850512938736 -0.274256049166114 0.783887857658025 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP183) -0.749633116237323 0.77496075859351 -0.967317516306045 0.33338532982881 1 FALSE Oribacterium sp._HMT_078 (SP186) 0.285131406382266 0.689984116793791 0.413243434801385 0.679428268177156 1 FALSE Actinomyces sp._HMT_171 (SP189) -1.43685798288445 1.02048973391805 -1.40800826811634 0.159128621733004 1 FALSE Catonella morbi (SP19) -0.690167078256452 0.643454014026625 -1.07259736237793 0.283451808704608 1 FALSE Actinomyces sp._HMT_175 (SP190) 0.580432722905652 0.822717069782814 0.705507086487069 0.480494723462472 1 FALSE Tannerella forsythia (SP193) 0.55266590864397 0.451269292114991 1.22469203710662 0.220691275488035 1 FALSE Slackia exigua (SP195) 0.305852988553086 0.269038495391794 1.13683726972856 0 0 TRUE Alloprevotella rava (SP199) 0.460355316253379 0.289980198112811 1.58754052604063 0 0 TRUE Granulicatella adiacens (SP2) -0.186005177376647 0.745362749452726 -0.249549870198395 0.802935469894906 1 FALSE Neisseria mucosa (SP205) 0.118708621071726 0.258042743595877 0.460034719122489 0 0 TRUE Peptostreptococcus stomatis (SP208) -1.15257870497688 0.69209377645533 -1.66535048310938 0.0958428522424113 1 FALSE Tannerella sp._HMT_286 (SP212) -1.28998752168338 0.622698094836819 -2.07160987383689 0.0383018383645374 1 FALSE Capnocytophaga sputigena (SP216) -0.513303372516792 0.67437721477123 -0.761151713423356 0.446566455508663 1 FALSE Ruminococcaceae_[G-1] bacterium_HMT_075 (SP218) -0.792529829957988 0.544082676237128 -1.45663492805747 0.145217180841391 1 FALSE Actinomyces sp._HMT_169 (SP22) 0.0770202181286391 0.952340691973206 0.0808746478836862 0.935541641963623 1 FALSE Streptococcus constellatus (SP222) 0.49704119580271 0.305368128689493 1.62767869042455 0 0 TRUE Prevotella melaninogenica (SP223) -0.387931382169211 0.622077905750774 -0.623605787286438 0.532886508986001 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_155 (SP229) -0.343978703150142 0.530444510842193 -0.64847254730566 0.516679361186755 1 FALSE Kingella oralis (SP232) -2.33210597282798 0.826363117909338 -2.82213221075029 0.00477055059311141 0.787140847863383 FALSE Arachnia propionica (SP235) -0.26438655015059 0.75032943038715 -0.352360629136156 0.724567824368209 1 FALSE Scardovia wiggsiae (SP236) -0.262845709851393 0.734936294287556 -0.357644209293262 0.720609589442998 1 FALSE Alloprevotella sp._HMT_473 (SP238) 0.116188208556852 0.277847526171151 0.418172550095989 0 0 TRUE Fretibacterium sp._HMT_359 (SP239) 0.420670744428118 0.271511000717416 1.54936906171969 0 0 TRUE Porphyromonas catoniae (SP24) -0.436083738699584 0.514120855273439 -0.848212505341082 0.39631963406637 1 FALSE Actinomyces johnsonii (SP242) -0.76774988930404 0.748538415343559 -1.02566531465411 0.305049369034817 1 FALSE Dialister invisus (SP25) -0.0739904215825151 0.807068213663112 -0.0916780271232443 0.926953855673005 1 FALSE Peptidiphaga sp._HMT_183 (SP251) -0.607287786159931 0.847286199839248 -0.716744573764035 0.473531717021729 1 FALSE Actinomyces massiliensis (SP253) 0.222040990077024 0.76419399635306 0.290555789677312 0.771391076588978 1 FALSE Cardiobacterium hominis (SP257) -0.645792257116355 0.673406096814888 -0.958993778302362 0.337561879513111 1 FALSE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP26) 1.19577255911957 0.405563444973433 2.94842292603049 0.00319399772905259 0.530203623022731 FALSE Fretibacterium sp._HMT_360 (SP260) -0.128128590630026 0.491261002699209 -0.260815716952964 0.794234623460257 1 FALSE Mycoplasma faucium (SP271) -0.0484490912281849 0.351063797480225 -0.138006514986536 0.89023526860502 1 FALSE Prevotella nanceiensis (SP277) -0.56333544318875 0.480232758438455 -1.17304668057322 0.240777086584924 1 FALSE Olsenella uli (SP281) 0.142936868108253 0.267463874989248 0.534415603280999 0 0 TRUE Peptidiphaga gingivicola (SP286) 0.737999236122703 0.337830173174736 2.18452730017394 0 0 TRUE Peptostreptococcaceae_[XI][G-4] bacterium_HMT_369 (SP287) -0.156549242811784 0.459962968169628 -0.340351840572631 0.733591581679656 1 FALSE Leptotrichia sp._HMT_417 (SP288) -0.848060661443667 0.639478383473731 -1.32617565090612 0.184781522554769 1 FALSE Capnocytophaga sp._HMT_338 (SP291) -0.666836873948558 0.4821579496253 -1.38302577913893 0.166656961552992 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP292) 1.12289063220975 0.630247214604421 1.78166694939626 0.0748035596296885 1 FALSE Phocaeicola abscessus (SP293) -0.169860358200573 0.433444312380803 -0.391885078079747 0.695143128917456 1 FALSE Neisseria elongata (SP295) 0.223294735648004 0.541094391022384 0.412672427126982 0.679846628952662 1 FALSE Fusobacterium periodonticum (SP296) -0.416980969073965 0.569264720114955 -0.732490446605864 0.463869271631362 1 FALSE Mogibacterium neglectum (SP298) 0.158748149853686 0.260444322429123 0.609528164688203 0 0 TRUE Stomatobaculum longum (SP3) -0.384226614989763 0.572117677546682 -0.671586685867457 0.501846856635404 1 FALSE Tannerella sp._HMT_808 (SP30) 0.109317139385898 0.234485380484965 0.466200234572438 0 0 TRUE Bacteroidetes_[G-3] bacterium_HMT_365 (SP309) -0.342064978662381 0.338548274608144 -1.01038759999089 0.312309626384366 1 FALSE Porphyromonas pasteri (SP31) -1.08168351682256 0.739972770318371 -1.46178827142135 0.143799239086875 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_145 (SP314) 0.051061678874064 0.232913211005121 0.219230496431314 0 0 TRUE Fretibacterium sp._HMT_362 (SP315) -0.399686319128828 0.47824732962103 -0.83573141839714 0.403306016024804 1 FALSE Bulleidia extructa (SP316) 0.189752081340405 0.25774315963192 0.736206080546959 0 0 TRUE Neisseria sicca (SP318) 0.311154770815272 0.316225568913046 0.983964617044714 0 0 TRUE Prevotella oris (SP32) 0.775819452713511 0.653980198544889 1.18630419459139 0.235502190741848 1 FALSE Megasphaera micronuciformis (SP320) -0.734819656196513 0.487239142189574 -1.5081293610656 0.131521421942577 1 FALSE Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP323) -0.464872176227265 0.593004765440136 -0.783926543798061 0.433083213573166 1 FALSE Shuttleworthia satelles (SP326) 0.259521273462023 0.275610874763404 0.941622037536826 0 0 TRUE Actinomyces dentalis (SP346) -2.29094334181588 0.866711139402685 -2.64326052552496 0.00821118276078713 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_132 (SP352) -0.165525281183274 0.342256961814512 -0.483628675676088 0.628649419978389 1 FALSE Gemella haemolysans (SP354) -0.277892581789827 0.411039871573328 -0.676072082073555 0.498994880878257 1 FALSE Cardiobacterium valvarum (SP356) -1.15872269391225 0.62612400066218 -1.85062813865432 0.0642230687129293 1 FALSE Haemophilus haemolyticus (SP357) -0.376670088529215 0.442793952481389 -0.850666741084381 0.394954503404115 1 FALSE Alloprevotella tannerae (SP36) 0.0243714487871869 0.697202576481302 0.0349560509517718 0.972114785696956 1 FALSE Anaerolineae_[G-1] bacterium_HMT_439 (SP360) 0.0217462103335968 0.205631614581055 0.105753244110356 0 0 TRUE Streptococcus parasanguinis_clade_411 (SP37) -0.56797373488234 1.00011003110978 -0.567911246977576 0.570095234614968 1 FALSE Solobacterium moorei (SP371) -0.087122238802102 0.488074457514479 -0.178501942604766 0.858328795718529 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_150 (SP382) 0.438885425415176 0.417147519109288 1.0521108368385 0.292748700778797 1 FALSE Streptococcus mutans (SP4) -3.03271689293668 1.15386823747364 -2.6283043370504 0.00858117054988295 1 FALSE Prevotella oralis (SP405) -0.0596850821089484 0.43622601962345 -0.136821462783143 0.891171918337104 1 FALSE Rothia mucilaginosa (SP41) -0.233219535236774 0.846519470978842 -0.275504041232624 0.782929021455811 1 FALSE Lancefieldella rimae (SP42) 1.49657863771723 0.502594803545553 2.97770416080632 0.00290416153799874 0.484994976845789 FALSE Pseudoramibacter alactolyticus (SP423) 0.147082016852402 0.251675549416518 0.584411227842338 0 0 TRUE Fusobacterium nucleatum (SP43) 0.646473527343118 0.662926440320399 0.975181389703918 0.329470291830957 1 FALSE Campylobacter concisus (SP44) 0.132937888340774 0.584714424741223 0.227355239952577 0.820147522267637 1 FALSE Capnocytophaga sp._HMT_380 (SP45) -0.547914955936327 0.5302770572921 -1.03326166652258 0.301481461259588 1 FALSE Butyrivibrio sp._HMT_080 (SP454) -0.278732856092779 0.360216709099986 -0.773792134155029 0.439053724808756 1 FALSE Campylobacter showae (SP46) -0.378613749603739 0.603114013059046 -0.627764803015234 0.530158026449775 1 FALSE Peptococcus sp._HMT_167 (SP47) -0.308726463929613 0.573947900104733 -0.537899805667513 0.590646222602608 1 FALSE Eikenella corrodens (SP48) -0.0708791739643072 0.577375156186911 -0.122761038823364 0.902296327347485 1 FALSE Actinomyces sp._HMT_170 (SP49) 0.0911959592035264 0.868306455945291 0.105027388175117 0.916354076280821 1 FALSE Schaalia meyeri (SP51) 0.181743232917183 0.562244529929669 0.323245889008323 0.746509030275236 1 FALSE Veillonella parvula (SP52) -1.62405244173406 0.653342906293853 -2.48575813112695 0.0129275794634751 1 FALSE Streptococcus mitis (SP57) 0.156135744398662 0.833364715238829 0.187355837778561 0.851381645772676 1 FALSE Fusobacterium nucleatum_subsp._vincentii (SP58) 0.072832855478607 0.734169248353452 0.0992044486226464 0.920975942794966 1 FALSE Prevotella denticola (SP59) 0.178057910242299 0.785011591106813 0.226822014170835 0.820562144969199 1 FALSE Corynebacterium matruchotii (SP6) -2.85671274878442 0.60654788812383 -4.70978929235215 2.47973015449504e-06 0.000426513586573147 TRUE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP60) -0.722129602063157 0.512078852754041 -1.4101921963374 0.158482939436652 1 FALSE Rothia aeria (SP61) 0.205662378019462 0.742722770060908 0.276903289234819 0.781854366874026 1 FALSE Leptotrichia sp._HMT_215 (SP62) -1.19528852459316 0.682982831724394 -1.75010039648478 0.0801009913703707 1 FALSE Haemophilus parainfluenzae (SP63) -0.247626463166847 1.0146955154803 -0.244040167113219 0.807199711317579 1 FALSE Fretibacterium fastidiosum (SP65) 0.490338338425111 0.475941851529463 1.03024841553518 0.302893407404846 1 FALSE Rothia dentocariosa (SP66) -0.459859054070835 0.967986972603274 -0.475067399754466 0.634738933882199 1 FALSE Lachnoanaerobaculum saburreum (SP67) -1.94198975016748 0.861743609370982 -2.25355863281076 0.0242239482224112 1 FALSE Aggregatibacter sp._HMT_458 (SP68) -0.0439843776892628 0.40930643318028 -0.107460753420139 0.914423459213293 1 FALSE Prevotella sp._HMT_300 (SP69) 0.20183867263553 0.563082249826299 0.35845326805772 0.72000413414919 1 FALSE Streptococcus sanguinis (SP7) -1.20869035185318 0.99757705135015 -1.21162605957836 0.225655554498458 1 FALSE Bergeyella sp._HMT_322 (SP70) 0.423908456790565 0.482197428429889 0.879118037130306 0.379337278881734 1 FALSE Treponema socranskii (SP72) 0.605752066644503 0.705514792319693 0.858595841276161 0.390563533315904 1 FALSE Prevotella intermedia (SP73) -0.0999550696445805 0.584580228587498 -0.170986059323454 0.864234727217304 1 FALSE Lachnospiraceae_[G-8] bacterium_HMT_500 (SP76) -0.405355103292068 0.431274172387401 -0.939901179447282 0.347268252301679 1 FALSE Gemella morbillorum (SP77) -0.289987698050206 0.630210785292682 -0.460143978519076 0.645412878938024 1 FALSE Anaeroglobus geminatus (SP79) 0.0867028779456017 0.550845616718592 0.157399596754702 0.874929931238364 1 FALSE Capnocytophaga granulosa (SP8) -0.471810931695772 0.687742568156612 -0.686028397166673 0.492695201429749 1 FALSE Veillonella atypica (SP80) 0.119922637226253 0.509794216321004 0.235237343592655 0.814024523093933 1 FALSE Bacteroidetes_[G-5] bacterium_HMT_511 (SP81) 0.0967778874624671 0.249975734184092 0.387149127807725 0 0 TRUE Capnocytophaga gingivalis (SP82) -0.724793188449333 0.801736441243771 -0.90402924348172 0.365979895124354 1 FALSE Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP83) -0.376063067604841 0.442336252092868 -0.850174648416308 0.395227994212528 1 FALSE Treponema denticola (SP84) -0.54128471747601 0.607077173272388 -0.89162423050478 0.372594378148494 1 FALSE Leptotrichia wadei (SP85) -1.25433494939877 1.0355146194855 -1.21131553895587 0.225774495575154 1 FALSE Streptococcus salivarius (SP87) -0.0821734318248735 0.754320674179622 -0.10893700071822 0.913252458940722 1 FALSE Streptococcus sp._HMT_064 (SP9) 0.117585394979139 0.674197738228887 0.174407875185157 0.861544925669958 1 FALSE Capnocytophaga leadbetteri (SP92) 0.717340703241287 0.526616035596198 1.36217026211358 0.173144158432549 1 FALSE Parvimonas micra (SP93) 1.15341845235094 0.78893172055933 1.46200035097232 0.14374111369501 1 FALSE Bifidobacterium dentium (SP95) 0.191850671718225 0.286126514340658 0.670509939144649 0 0 TRUE Corynebacterium durum (SP96) -0.811921391386331 0.849628121657292 -0.95561972431255 0.339264392667263 1 FALSE Lancefieldella parvula (SP97) 0.470003113617009 0.600981849494174 0.782058749382523 0.434180047878719 1 FALSE Actinomyces naeslundii_nov_97.422% (SPN109) 0.248858992075908 0.667173842344198 0.373004719731683 0.709144931223983 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) -1.31630972180865 0.734145491310314 -1.79298209604104 0.0729757869350494 1 FALSE Streptococcus sanguinis_nov_97.727% (SPN14) -0.363790790173721 0.749357313425672 -0.48547039397088 0.627342708832112 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.517460265760246 0.297976717977423 1.73657951961016 0 0 TRUE Actinomyces viscosus_nov_95.841% (SPN468) 0.165761743129476 0.459928219560744 0.360407855138324 0.718542153239473 1 FALSE Prevotella sp._HMT_300_nov_97.638% (SPN520) -0.364524979113561 0.380309713423567 -0.958495053497551 0.337813184595633 1 FALSE Actinomyces israelii_nov_97.037% (SPN575) 0.281080044917746 0.289488782317072 0.970953149438044 0 0 TRUE Corynebacterium durum_nov_97.183% (SPN646) -0.493819789367386 0.541194967464601 -0.912461902003341 0.361525616133968 1 FALSE Veillonella dispar_parvula (SPP13) -1.25846912682686 0.352063145698328 -3.57455513933629 0.000350823876535726 0.0599908828876092 FALSE