SubgroupSmoker 12 Weeks P2...1 SubgroupSmoker 12 Weeks P2...2 SubgroupSmoker 12 Weeks P2...3 SubgroupSmoker 12 Weeks P2...4 SubgroupSmoker 12 Weeks P2...5 SubgroupSmoker 12 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Actinomyces sp._HMT_897 (SP1) -0.155584841677268 0.561041593080525 -0.277314273301903 0.781538800685257 1 FALSE Leptotrichia buccalis (SP10) -0.0116593036876275 0.336271321831038 -0.0346723105144416 0.972341040655285 1 FALSE Capnocytophaga endodontalis (SP101) -1.76525502446485 0.768490541143029 -2.29704196728208 0.0216163757805018 1 FALSE Prevotella veroralis (SP102) 0.0347784042918327 0.627428266677096 0.0554300884083874 0.955795825595173 1 FALSE Selenomonas artemidis (SP103) 0.00775873321823556 0.283981993304369 0.027321215433261 0.978203535714642 1 FALSE Alloprevotella sp._HMT_913 (SP105) 0.0522720232174378 0.257167975144636 0.203260235602971 0 0 TRUE Filifactor alocis (SP107) 0.391781231773766 0.464147744359871 0.844087333256549 0.398620605369227 1 FALSE Actinomyces israelii (SP109) -0.769126747992256 0.764488123624304 -1.00606762122865 0.314383042799529 1 FALSE Prevotella pleuritidis (SP11) -0.00432818406381597 0.660119836757526 -0.00655666414309829 0.994768576392894 1 FALSE Prevotella oulorum (SP111) 0.250767080463421 0.623872207166161 0.401952639631904 0.687718881460519 1 FALSE Parvimonas sp._HMT_110 (SP112) 0.0897090448546787 0.59481148261045 0.150819288929952 0.88011826995059 1 FALSE Treponema sp._HMT_231 (SP114) -0.0652210967060877 0.487334844645538 -0.133832204741129 0.893535260566362 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP117) 1.03298035438628 0.667418536067176 1.54772500097646 0.121688520120902 1 FALSE Prevotella sp._HMT_317 (SP118) 0.432761497948527 0.629638309068963 0.687317610309393 0.491882603815101 1 FALSE Prevotella loescheii (SP119) 0.454797685910567 0.331916803656211 1.37021591224297 0 0 TRUE Streptococcus oralis (SP12) 0.356934953597675 0.908390287608196 0.392931274658924 0.694370241741779 1 FALSE Treponema sp._HMT_257 (SP120) -0.322479029451806 0.370531537099075 -0.870314661948949 0.384128468495195 1 FALSE Schaalia sp._HMT_180 (SP121) -0.228702766857609 0.747982601566406 -0.3057594740555 0.759787786603717 1 FALSE Schaalia sp._HMT_178 (SP122) 0.209015154746681 0.326299132880944 0.640563010086036 0.521806638675143 1 FALSE Streptococcus cristatus (SP123) -1.98787576150608 0.821574675669471 -2.41959230289837 0.0155379167828664 1 FALSE Prevotella salivae (SP124) -0.60948838076434 0.666928052718182 -0.913874260169839 0.360782920210195 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) -0.109370640811527 0.597588912777224 -0.183019862773624 0.854782433606092 1 FALSE Selenomonas sp._HMT_134 (SP127) 0.0344259009824534 0.263394159250698 0.130701079630574 0 0 TRUE Prevotella maculosa (SP129) -0.336995931927492 0.518488635021713 -0.649958184548018 0.515719232449192 1 FALSE Selenomonas sputigena (SP13) 0.0816492808140556 0.681357519137735 0.119833242491231 0.904615247978719 1 FALSE Lautropia mirabilis (SP131) 0.179225384661898 0.742759644849167 0.241296610424081 0.809325237780856 1 FALSE Porphyromonas endodontalis (SP132) 0.419099313556777 0.649947321068631 0.644820433858704 0.5190435583742 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP135) 0.540756552582381 0.584000536974328 0.925952149605903 0.354470848009062 1 FALSE Olsenella sp._HMT_807 (SP136) 1.50080447094826 0.493389024594537 3.04182783997193 0.00235146343209321 0.38799146629538 FALSE Actinomyces sp._HMT_525 (SP137) -0.129659771750724 0.456070729912699 -0.284297507484296 0.776182396114251 1 FALSE Bacteroidales_[G-2] bacterium_HMT_274 (SP14) -0.487694251484992 0.576060150701112 -0.846602999515638 0.397216441479238 1 FALSE Capnocytophaga sp._HMT_864 (SP140) 0.275449411349817 0.28232334793819 0.975652256044097 0 0 TRUE Schaalia odontolytica (SP141) -0.300428779295986 0.579396078213948 -0.518520560619068 0.604095118549067 1 FALSE Actinomyces viscosus (SP146) -0.2608773625499 0.452483821536304 -0.576545171635421 0.564246746607951 1 FALSE Streptococcus intermedius (SP147) -0.793058266031087 0.964383566545098 -0.82234734554034 0.410879237781505 1 FALSE Campylobacter gracilis (SP151) 0.332022639148625 0.760788517052892 0.436419099009012 0.66253268434886 1 FALSE Actinomyces sp._HMT_448 (SP153) -1.49314999884043 1.06753831496963 -1.39868515996347 0.161907416298456 1 FALSE Streptococcus gordonii (SP155) -0.442280246672083 1.00661137364847 -0.43937537191641 0.660389568700544 1 FALSE Peptoanaerobacter [Eubacterium] yurii (SP157) -0.220557709876095 0.372441069137281 -0.592194921969784 0.553720069464887 1 FALSE Selenomonas noxia (SP161) -0.249676307547677 0.720423182377951 -0.346568952325428 0.728915174327465 1 FALSE Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP162) -0.161744701029466 0.389009894206173 -0.415785571108744 0.677566918083552 1 FALSE Mogibacterium timidum (SP165) 0.557962515392246 0.493265683798494 1.13116021186704 0.257987665165239 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP166) 0.327294922609652 0.289774408457016 1.12948180742538 0 0 TRUE Leptotrichia hongkongensis (SP167) -1.9586033615146 0.833884443755503 -2.34877071539287 0.0188355014338987 1 FALSE Prevotella sp._HMT_314 (SP17) 0.187888256044356 0.283149003817836 0.663566721093725 0 0 TRUE Capnocytophaga ochracea (SP172) -0.320023989611007 0.528354516747482 -0.605699354253759 0.544714412906989 1 FALSE Actinomyces oris (SP173) -0.0943964996643706 0.898847215888777 -0.105019516104338 0.916360322740398 1 FALSE Actinomyces naeslundii (SP179) 0.433135429876714 0.332427057571921 1.3029487823295 0 0 TRUE Treponema sp._HMT_237 (SP18) 0.653511898841742 0.303638996296767 2.15226603569398 0 0 TRUE Streptococcus anginosus (SP180) 0.276370873610894 0.669479390416548 0.41281461022861 0.679742446291528 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP183) -0.0012331003769302 0.523785942093077 -0.00235420670513351 0.998121616552126 1 FALSE Oribacterium sp._HMT_078 (SP186) -0.391138211250747 0.640995985242956 -0.610203839424196 0.541726786742113 1 FALSE Actinomyces sp._HMT_171 (SP189) -0.440493093176622 0.551675221324532 -0.79846452432471 0.424600972107167 1 FALSE Catonella morbi (SP19) 0.737222451029476 0.370978080678771 1.98723991908254 0.0468958160897866 1 FALSE Actinomyces sp._HMT_175 (SP190) 0.342693885201463 0.808020395519645 0.424115390034274 0.671481662173798 1 FALSE Schaalia georgiae (SP191) -0.784268732896598 0.532975761917865 -1.4714904296482 0.141158533820182 1 FALSE Leptotrichia sp._HMT_212 (SP192) -0.274582666628148 0.315709964708055 -0.869730757095554 0.384447559688273 1 FALSE Tannerella forsythia (SP193) 0.216906504783064 0.509307848995947 0.425884865530101 0.670191743518107 1 FALSE Bergeyella sp._HMT_900 (SP196) -0.419797906104908 0.440291069491804 -0.953455418910609 0.340359373787874 1 FALSE Alloprevotella rava (SP199) 0.386557045176367 0.293646327895466 1.31640347061985 0 0 TRUE Granulicatella adiacens (SP2) -0.852566928776595 0.817288470776325 -1.04316524613 0.296871766493798 1 FALSE Treponema maltophilum (SP203) 0.058017760664924 0.258522443244828 0.224420595506981 0 0 TRUE Peptostreptococcus stomatis (SP208) 0.593113028400629 0.37585532603295 1.57803544959912 0.11455746605482 1 FALSE Tannerella sp._HMT_286 (SP212) -0.73795286316401 0.467665485711724 -1.5779502351792 0.114577042921737 1 FALSE Capnocytophaga sputigena (SP216) -0.211994685334305 0.559695683656264 -0.378767768851512 0.70486032384752 1 FALSE Actinomyces sp._HMT_169 (SP22) -0.554987711940537 0.88272922947897 -0.628717950427583 0.52953372422553 1 FALSE Streptococcus constellatus (SP222) -0.202008354046834 0.469799479936244 -0.429988458212529 0.667204037021901 1 FALSE Prevotella melaninogenica (SP223) -0.505632830876845 0.674765073289952 -0.749346477599278 0.453648401316623 1 FALSE Lachnoanaerobaculum orale (SP224) -0.458381744299986 0.507419209831486 -0.903359067647862 0.366335356713882 1 FALSE Campylobacter sp._HMT_044 (SP228) 0.17550146179325 0.285942932216185 0.613763943850739 0 0 TRUE Veillonellaceae_[G-1] bacterium_HMT_155 (SP229) -0.173554169242575 0.384989320020466 -0.450802555336726 0.652131859445989 1 FALSE Kingella oralis (SP232) -0.820923086999667 0.821435726003345 -0.99937592317031 0.317612618748974 1 FALSE Arachnia propionica (SP235) -0.975087201137455 0.635462458880215 -1.53445288153719 0.12491827655994 1 FALSE Scardovia wiggsiae (SP236) -0.301050055330017 0.795184881844571 -0.37859127129238 0.7049914049984 1 FALSE Gemella sanguinis (SP237) -0.895441482293105 0.548098531580219 -1.6337235564406 0.102316909796003 1 FALSE Alloprevotella sp._HMT_473 (SP238) -0.527136991466752 0.539055874034972 -0.977889337372386 0.328129059280272 1 FALSE Porphyromonas catoniae (SP24) 0.420352455763863 0.301133090601124 1.39590257226382 0 0 TRUE Dialister invisus (SP25) 0.641356818182053 0.715041445062683 0.896950551063274 0.369745303903933 1 FALSE Peptidiphaga sp._HMT_183 (SP251) -1.33454880480759 0.729861923090528 -1.82849490100343 0.067475310238507 1 FALSE Actinomyces massiliensis (SP253) -0.641587462299973 0.601504188630722 -1.06663839492207 0.28613515565593 1 FALSE Selenomonas dianae (SP255) -0.170697125910169 0.326048147485079 -0.523533494138256 0.600603048912854 1 FALSE Cardiobacterium hominis (SP257) -0.71166528651889 0.598554156803423 -1.18897392730432 0.234449926924735 1 FALSE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP26) 0.710667866926537 0.520380438334065 1.36566983417296 0.172042616638096 1 FALSE Fretibacterium sp._HMT_360 (SP260) -0.251375481535916 0.468462678565495 -0.536596602114957 0.591546291725901 1 FALSE Treponema lecithinolyticum (SP264) -0.336604255376913 0.433635097766434 -0.776238494325512 0.437608181194709 1 FALSE Mycoplasma faucium (SP271) -0.0188981060748565 0.250321740562783 -0.0754952647435621 0 0 TRUE Peptidiphaga gingivicola (SP286) 0.446054662810093 0.337542922715338 1.32147538221759 0 0 TRUE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP292) 0.857589577662066 0.732581010385721 1.17064128813621 0.241742993936427 1 FALSE Neisseria elongata (SP295) -0.333711219011606 0.444442668788739 -0.750853242604013 0.452740982633656 1 FALSE Mogibacterium neglectum (SP298) -0.331875757735189 0.494399329031281 -0.671270647525881 0.502048129990185 1 FALSE Stomatobaculum longum (SP3) -0.493254570140179 0.638079415764363 -0.773030061703688 0.439504589784507 1 FALSE Mitsuokella sp._HMT_521 (SP300) 0.0526473600742099 0.26867824370815 0.195949472304121 0 0 TRUE Bacteroidetes_[G-3] bacterium_HMT_365 (SP309) 0.134499321569754 0.268537012866775 0.500859528203963 0 0 TRUE Porphyromonas pasteri (SP31) -1.86816982777344 0.730639082416663 -2.5568983000393 0.0105610088799051 1 FALSE Bulleidia extructa (SP316) 0.349305847116571 0.289706529979225 1.20572307134955 0 0 TRUE Treponema sp._HMT_268 (SP317) 0.00620571349656412 0.249032822937165 0.0249192593304455 0 0 TRUE Neisseria sicca (SP318) -0.433544308415064 0.668925049694676 -0.648120904745533 0.516906754125198 1 FALSE Prevotella oris (SP32) -0.12905272264056 0.873209579996714 -0.147791235456951 0.882507526470702 1 FALSE Megasphaera micronuciformis (SP320) 0.0286876804424078 0.53023410913937 0.054103800468384 0.956852464348745 1 FALSE Shuttleworthia satelles (SP326) -0.0871274732341613 0.445609716423512 -0.19552417737533 0.844982612118634 1 FALSE Actinomyces dentalis (SP346) 1.06423236857313 0.382877242140306 2.77956548846833 0 0 TRUE Peptostreptococcaceae_[XI][G-6] [Eubacterium]_nodatum (SP351) 0.203090190066495 0.292302056533464 0.694795625029222 0 0 TRUE Veillonellaceae_[G-1] bacterium_HMT_132 (SP352) -0.204240591126485 0.332026450807442 -0.615133495026677 0.538466563425448 1 FALSE Gemella haemolysans (SP354) -2.09026928198536 0.783892491780823 -2.66652545330133 0.00766398027231989 1 FALSE Haemophilus haemolyticus (SP357) -0.548333280572368 0.561734352563464 -0.976143399580354 0.328993407099517 1 FALSE Alloprevotella tannerae (SP36) -0.0171610685207108 0.661387774425758 -0.0259470603846747 0.979299563908142 1 FALSE Streptococcus parasanguinis_clade_411 (SP37) 0.0233970675951387 0.868452632999328 0.0269410981164666 0.978506713845984 1 FALSE Solobacterium moorei (SP371) 0.599286236131676 0.314439139642611 1.90588944115806 0 0 TRUE Veillonellaceae_[G-1] bacterium_HMT_150 (SP382) 0.321892601481183 0.300104728981839 1.07260089693775 0 0 TRUE Streptococcus vestibularis (SP39) -0.54261199543204 0.625304451898082 -0.867756488515262 0.385527654533684 1 FALSE Streptococcus mutans (SP4) -2.90618983239821 1.1839680312668 -2.45461849952883 0.0141034172900178 1 FALSE Prevotella oralis (SP405) -0.81168269829653 0.524917638200843 -1.54630486618544 0.122030957303162 1 FALSE Rothia mucilaginosa (SP41) 0.741886336689447 0.592770601976364 1.25155723683987 0.210731245087126 1 FALSE Lancefieldella rimae (SP42) 0.568743002397118 0.807314194366035 0.704487802105026 0.481129043742972 1 FALSE Fusobacterium nucleatum (SP43) 1.00195759720676 0.796987534286783 1.25718101488677 0.208688096303061 1 FALSE Campylobacter concisus (SP44) 0.749972408967056 0.468741836076675 1.59996900478151 0.109605459600629 1 FALSE Capnocytophaga sp._HMT_380 (SP45) -0.481456722575285 0.452360054674953 -1.06432192144207 0.287182890635006 1 FALSE Campylobacter showae (SP46) 0.430037305837544 0.501724376376216 0.857118621470132 0.391379330846039 1 FALSE Peptococcus sp._HMT_167 (SP47) 0.0644397045273583 0.451487083223194 0.142727681304456 0.886505254011444 1 FALSE Eikenella corrodens (SP48) -0.681934587474014 0.562465298159085 -1.21240295126819 0.2253581717502 1 FALSE Actinomyces sp._HMT_170 (SP49) 0.467891720854243 0.409413034467142 1.14283542892867 0.253106925965746 1 FALSE Schaalia meyeri (SP51) 0.615477006421754 0.339213256690019 1.81442497981201 0 0 TRUE Veillonella parvula (SP52) -1.1703239987683 0.765180605445724 -1.52947420574856 0.12614692881212 1 FALSE Streptococcus mitis (SP57) 0.124376650714116 0.874512363785264 0.142224004902299 0.886903071352041 1 FALSE Fusobacterium nucleatum_subsp._vincentii (SP58) 0.216015060555584 0.585514976980241 0.368931742224031 0.712178602849138 1 FALSE Prevotella denticola (SP59) -0.44560603265102 0.882185785068371 -0.505115861299539 0.613477461582181 1 FALSE Corynebacterium matruchotii (SP6) -0.656404842565657 0.927224263687464 -0.707924574746579 0.478992097852293 1 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP60) -0.263540038867254 0.484904050214279 -0.543489044380627 0.586793131976717 1 FALSE Rothia aeria (SP61) -1.321431782892 0.705629868486111 -1.87269819760757 0.0611100724062713 1 FALSE Leptotrichia sp._HMT_215 (SP62) -0.816318325022675 0.569842099373902 -1.43253425101371 0.1519909831101 1 FALSE Haemophilus parainfluenzae (SP63) -0.587643990051752 0.977259144950683 -0.601318486593858 0.547627878887608 1 FALSE Prevotella multiformis (SP64) -0.239756190398174 0.371649108691321 -0.645114396325131 0.518853055123977 1 FALSE Fretibacterium fastidiosum (SP65) 0.642221803119367 0.328012390946553 1.95791933733385 0 0 TRUE Rothia dentocariosa (SP66) -1.11404125934283 0.913375195503116 -1.21969729945336 0.222579645719873 1 FALSE Lachnoanaerobaculum saburreum (SP67) -0.210877430238747 0.659505666868096 -0.319750747920296 0.749157286380754 1 FALSE Aggregatibacter sp._HMT_458 (SP68) -1.07373333887816 0.682712923751123 -1.57274500236292 0.115777874970576 1 FALSE Prevotella sp._HMT_300 (SP69) 0.296437779500021 0.501149073992601 0.591516167311919 0.554174625809129 1 FALSE Streptococcus sanguinis (SP7) -0.963610692755445 0.917354711549916 -1.05042322301629 0.293523573160014 1 FALSE Bergeyella sp._HMT_322 (SP70) 0.0194598399655856 0.628083002620362 0.030982911310128 0.975283167929407 1 FALSE Treponema socranskii (SP72) 0.43609994510905 0.593903429847345 0.734294370418341 0.462769348209975 1 FALSE Prevotella intermedia (SP73) 0.722044298233784 0.352142093878409 2.05043450012284 0 0 TRUE Gemella morbillorum (SP77) 0.272324907166627 0.586050368982675 0.464678330702795 0.642161828482737 1 FALSE Anaeroglobus geminatus (SP79) 0.52216520762385 0.328845736276275 1.58787282309527 0 0 TRUE Capnocytophaga granulosa (SP8) -0.397516793554521 0.565012864873715 -0.703553526419915 0.481710861718451 1 FALSE Capnocytophaga gingivalis (SP82) -0.393771925266045 0.682534411689594 -0.576926113206914 0.563989369424101 1 FALSE Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP83) -0.402836368973658 0.330389208220136 -1.21927822989076 0.22273860854545 1 FALSE Treponema denticola (SP84) 0.46858767283523 0.316355425658633 1.48120637368447 0 0 TRUE Leptotrichia wadei (SP85) 1.45577886043315 0.737725924396195 1.97333293068786 0.048457643424125 1 FALSE Porphyromonas gingivalis (SP86) -0.531185681717111 0.51191414960267 -1.03764602351664 0.299434882809443 1 FALSE Streptococcus salivarius (SP87) -1.77269135061227 0.794173118578509 -2.23212207658856 0.0256068957121822 1 FALSE Streptococcus sp._HMT_064 (SP9) -0.419840125511164 0.738190537889342 -0.568742220283105 0.569531091109853 1 FALSE Capnocytophaga leadbetteri (SP92) 0.446346731836754 0.533616928031199 0.836455345379631 0.402898788074323 1 FALSE Parvimonas micra (SP93) 0.904318827554321 0.849429091110486 1.06461956273722 0.287048123451721 1 FALSE Bifidobacterium dentium (SP95) -0.455933756496527 0.56596887096996 -0.805580977828596 0.420484497390231 1 FALSE Corynebacterium durum (SP96) -1.37297544677839 0.759902372814056 -1.80677873355496 0.0707967858374367 1 FALSE Lancefieldella parvula (SP97) -1.78583678614112 0.933936246410193 -1.91216134185327 0.055855502866708 1 FALSE Actinomyces naeslundii_nov_97.422% (SPN109) -0.0703982319396483 0.708397841767495 -0.0993766889012542 0.920839190693524 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) -1.99891819022794 0.814333774394643 -2.45466693520589 0.0141015173736194 1 FALSE Streptococcus sanguinis_nov_97.727% (SPN14) -0.0158066276954639 0.476244106384566 -0.033190180169285 0.973522928899449 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.145276266723081 0.574997205677381 0.252655604738004 0.800534357248664 1 FALSE Marseilla massiliensis_nov_77.473% (SPN44) -0.369475344492667 0.427135209708137 -0.865007932137298 0.387034435134076 1 FALSE Actinomyces viscosus_nov_95.841% (SPN468) 0.0454651734609448 0.263090542684417 0.172811888245946 0 0 TRUE Prevotella veroralis_nov_96.402% (SPN608) 0.0309380468945374 0.266767943139554 0.115973630603557 0 0 TRUE Veillonella dispar_parvula (SPP13) -0.995392417136061 0.729130841440482 -1.36517667414747 0.172197527836826 1 FALSE Streptococcus infantis_infantis_clade_638 (SPP16) -1.46421472720096 0.567515230273519 -2.58004481482421 0.00987874942777232 1 FALSE