Comp11OSS 24 Weeks P1...1 Comp11OSS 24 Weeks P1...2 Comp11OSS 24 Weeks P1...3 Comp11OSS 24 Weeks P1...4 Comp11OSS 24 Weeks P1...5 Comp11OSS 24 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mitis (SP1) 1.14123724319524 1.37415248667249 0.830502621989754 0.406254666009663 1 FALSE CorynebacteriumCorynebacterium durum (SP10) -0.860270569341073 1.51416645865591 -0.568147949931947 0.569934511061273 1 FALSE LachnoanaerobaculumLachnoanaerobaculum saburreum (SP101) 2.41712773759225 1.32496041969272 1.82430184454327 0.0681064517247473 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP111) -1.83720566632204 1.1925727846031 -1.5405396551402 0.123428864397128 1 FALSE StreptococcusStreptococcus salivarius (SP115) -1.48153277095345 1.58012015455985 -0.937607666529722 0.348446070043896 1 FALSE LeptotrichiaLeptotrichia hongkongensis (SP119) 0.856574130275688 1.54245488924299 0.555331722340406 0.578667784726187 1 FALSE SelenomonasSelenomonas sputigena (SP12) -0.156037296179872 1.2653316699504 -0.123317308722692 0.901855835066276 1 FALSE OlsenellaOlsenella sp._HMT_807 (SP124) -1.10931880400583 1.26591178888714 -0.87630023967233 0.380866834797403 1 FALSE SelenomonasSelenomonas noxia (SP128) -0.189846013075259 1.45113790274862 -0.130825618099885 0.895913256851198 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP129) -0.853114020115226 0.992126123311737 -0.859884645782246 0.389852633112263 1 FALSE ParvimonasParvimonas micra (SP13) -1.61350202935334 1.14372832560923 -1.41073889071855 0.158321619099006 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP130) 0.401803374493124 1.34419223642921 0.298918088948718 0.765002544788229 1 FALSE GemellaGemella haemolysans (SP131) -1.4625918106713 1.167279384908 -1.25299206820702 0.210208593322372 1 FALSE DialisterDialister invisus (SP134) -0.891554685799783 0.938031022669846 -0.950453305118011 0.341881969671769 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP136) -0.190024996015029 1.06989806535771 -0.177610374453285 0.859028976455737 1 FALSE LeptotrichiaLeptotrichia wadei (SP137) 1.68441644272429 1.568626614764 1.07381605467514 0.282905132864638 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP141) -0.442871973606454 0.882847163338688 -0.501640591936245 0.615920360567385 1 FALSE GemellaGemella morbillorum (SP142) 0.12529176670198 1.00309287161238 0.124905450180884 0.900598403545396 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP144) -1.6741687180546 0.993221384590106 -1.68559471637385 0 0 TRUE ButyrivibrioButyrivibrio sp._HMT_080 (SP148) -0.497320501570796 0.765376174337457 -0.649772645459337 0.515839090927362 1 FALSE CampylobacterCampylobacter showae (SP151) 0.898870582199589 0.769548697602616 1.16804899417003 0 0 TRUE PrevotellaPrevotella saccharolytica (SP154) -0.297200153175741 0.782500676895888 -0.379808173910735 0.704087814335141 1 FALSE PorphyromonasPorphyromonas endodontalis (SP156) -0.613177699771906 0.810663110276147 -0.756390283459464 0.449415231907222 1 FALSE ScardoviaScardovia wiggsiae (SP158) 1.15717281654942 0.9390601857691 1.23226693462856 0 0 TRUE CapnocytophagaCapnocytophaga endodontalis (SP159) 1.34255759080573 1.20190412394585 1.11702552978862 0.26398340955669 1 FALSE VeillonellaVeillonella sp._HMT_780 (SP160) -0.22496032648398 0.932559524485556 -0.241228919524551 0.809377698072495 1 FALSE StreptococcusStreptococcus intermedius (SP167) 1.08901843136739 1.21563187067869 0.895845574334431 0.370335245444269 1 FALSE FusobacteriumFusobacterium nucleatum (SP17) 1.42910126691278 1.15142191408497 1.24116212261643 0.214545864209765 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP174) -0.342585582362522 0.894956213781054 -0.38279591457905 0.70187109089567 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP175) -2.01719930620472 1.06411578260382 -1.89565772745967 0 0 TRUE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP176) -0.780687810771551 1.44752186166114 -0.539327129661209 0.589661152321147 1 FALSE CatonellaCatonella morbi (SP18) 1.50857766297493 0.813930638044546 1.85344744682331 0 0 TRUE LeptotrichiaLeptotrichia sp._HMT_215 (SP184) 0.573576067279803 1.10080345942449 0.521052202706261 0.602330406292425 1 FALSE StreptococcusStreptococcus australis (SP186) -0.27059845283705 1.32965904049109 -0.203509655179804 0.83873669984333 1 FALSE LautropiaLautropia mirabilis (SP194) -0.578567148950953 1.33497840641611 -0.43339064225329 0.664730997644402 1 FALSE FusobacteriumFusobacterium periodonticum (SP195) -0.695048357238798 1.14380082036407 -0.607665552309678 0.543409314424805 1 FALSE GranulicatellaGranulicatella adiacens (SP20) -1.47275712389231 1.18214723831577 -1.24583222474941 0.21282599632831 1 FALSE HaemophilusHaemophilus haemolyticus (SP201) -0.317352307953294 0.891992751359106 -0.355779021152081 0.722006061170055 1 FALSE NeisseriaNeisseria flavescens (SP209) -0.866310359176794 1.29606928258092 -0.668413618639022 0.503869604698578 1 FALSE StreptococcusStreptococcus cristatus (SP214) -0.82316463294698 1.04098341315182 -0.790756723447358 0.429085968225825 1 FALSE NeisseriaNeisseria sicca (SP215) -2.14501742164358 0.861681155276528 -2.4893400633268 0 0 TRUE PeptococcusPeptococcus sp._HMT_167 (SP218) -0.114241721330637 0.843186391876458 -0.135488098991256 0.892225973123823 1 FALSE OribacteriumOribacterium sp._HMT_078 (SP220) -0.42732563837699 0.936704935652794 -0.456200903947608 0.648245515455731 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP226) -0.244029979401658 0.908227199802802 -0.268688252735266 0.7881695924312 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP230) 0.227577993679935 1.1908869118401 0.191099584198379 0.848447573396371 1 FALSE TreponemaTreponema sp._HMT_231 (SP231) -0.31953098821452 0.868413402635163 -0.367948015593629 0.712911996562833 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP24) 0.48629926456068 1.03088544907485 0.471729681505448 0.637119748278846 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP244) 0.910177713050208 0.720859317505525 1.26262876950777 0 0 TRUE KingellaKingella oralis (SP253) 1.75235002523724 1.03886233298944 1.68679715260698 0.0916423631733555 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP264) 1.61378386051448 2.12431529753764 0.759672475354794 0.447450385397223 1 FALSE RothiaRothia aeria (SP269) -0.845941899182878 1.11374706540581 -0.759545794066491 0.44752613097168 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP27) -0.269989067636531 0.777750945107274 -0.347140777307949 0.728485560187593 1 FALSE LeptotrichiaLeptotrichia sp._HMT_212 (SP272) -0.172390521913417 1.02593695558715 -0.168032276227691 0.86655788731379 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP275) -3.38741477081151 1.01799996844383 -3.3275195243765 0 0 TRUE TannerellaTannerella sp._HMT_286 (SP28) 1.16711023427194 0.919375563690904 1.26945970761555 0 0 TRUE CapnocytophagaCapnocytophaga sp._HMT_902 (SP296) -0.138225462478973 0.983596407209481 -0.140530670370306 0.888240721475413 1 FALSE ActinomycesActinomyces naeslundii (SP3) 0.616207918325695 1.37334200111181 0.448692254243178 0.653653673029918 1 FALSE PrevotellaPrevotella melaninogenica (SP30) -0.0605131103616774 1.04192371743773 -0.0580782540496243 0.953686295903763 1 FALSE ActinomycesActinomyces oris (SP31) 1.44696873090928 1.2305014322869 1.17591795746232 0.239627662226953 1 FALSE LeptotrichiaLeptotrichia sp._HMT_221 (SP322) -0.0707881772556433 1.03098763227522 -0.0686605493990512 0.945259821080165 1 FALSE PrevotellaPrevotella marshii (SP33) -0.358929117891891 0.844463105815985 -0.425038246691744 0.670808793750582 1 FALSE GemellaGemella sanguinis (SP333) 0.017352510955801 1.32738738619687 0.0130726803164207 0.989569807285975 1 FALSE LancefieldellaLancefieldella parvula (SP338) -0.220715892077803 1.09211029540135 -0.202100367524408 0.839838260551113 1 FALSE StreptococcusStreptococcus gordonii (SP34) 1.16768536495483 1.51522556916523 0.770634675600237 0.440923501780914 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP35) 0.605780540637163 0.606428365516126 0.998931737174907 0.317827760655864 1 FALSE AggregatibacterAggregatibacter aphrophilus (SP37) 0.877667615954978 0.710825781398858 1.23471550824702 0 0 TRUE NeisseriaNeisseria perflava (SP387) -1.07961789393439 1.5843322614007 -0.681434014971015 0.495596905843598 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_338 (SP399) 0.836943322794175 0.684505427649854 1.22269786182367 0 0 TRUE StreptococcusStreptococcus parasanguinis_clade_411 (SP4) -0.934277963088194 1.76546020486142 -0.529197973715601 0.596668122181915 1 FALSE StreptococcusStreptococcus sanguinis (SP40) 1.05201875973276 1.42635153716038 0.737559242812709 0.460782330273416 1 FALSE StreptococcusStreptococcus mutans (SP41) 0.58060022224955 1.77831615129932 0.326488752759365 0.744054597512846 1 FALSE PrevotellaPrevotella oris (SP42) -0.516339386032033 0.82391579893679 -0.626689507226753 0.530862783208971 1 FALSE SchaaliaSchaalia meyeri (SP43) -0.817427850456761 1.21434190200586 -0.673144728932213 0.50085522010753 1 FALSE ActinomycesActinomyces dentalis (SP47) 0.457539506316283 1.54481638204555 0.296177274939587 0.767094702665398 1 FALSE EikenellaEikenella corrodens (SP48) 0.92677607291629 0.75759511402301 1.22331315997392 0 0 TRUE PrevotellaPrevotella denticola (SP49) -1.35050695954606 1.25204519574248 -1.07864074247351 0.28074791137639 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP5) -0.32111077887361 1.00968954784926 -0.318029219533479 0.750462772685678 1 FALSE TreponemaTreponema socranskii (SP51) -0.452198415881128 0.944532126439776 -0.478753875302896 0.632113733583259 1 FALSE SchaaliaSchaalia odontolytica (SP52) -0.441864331986864 1.03987910360153 -0.424918945343265 0.670895763284774 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP53) -1.12087920008175 1.78086796713423 -0.629400506251715 0.529086886634948 1 FALSE PrevotellaPrevotella oulorum (SP57) 0.517011182671185 1.20925237601923 0.427546137534289 0.668981587768273 1 FALSE RothiaRothia mucilaginosa (SP59) -0.923661341011064 1.74200030198968 -0.530230299016638 0.595952266064931 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP6) 0.370267232544255 1.24407170089113 0.297625315549765 0.765989150710001 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP62) 0.282888386827069 1.32679325515069 0.213212108012217 0.831161524569221 1 FALSE AlloprevotellaAlloprevotella tannerae (SP63) -0.966310947358259 1.0113172006362 -0.955497391669374 0.339326223768009 1 FALSE BergeyellaBergeyella sp._HMT_900 (SP66) -0.156425344473138 0.485149449225689 -0.322427129872653 0.747129134061592 1 FALSE StreptococcusStreptococcus anginosus (SP69) -0.461040506438368 1.36707294913465 -0.337246455450827 0.735931119976364 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP74) 0.474909674000748 1.55067688564348 0.306259594372992 0.75940700102741 1 FALSE CardiobacteriumCardiobacterium valvarum (SP77) 1.10518297486653 0.852048190589284 1.29708975040739 0 0 TRUE CampylobacterCampylobacter gracilis (SP78) 2.36999774439722 1.14876608426909 2.06308122850366 0.039104911326504 1 FALSE PrevotellaPrevotella histicola (SP79) -0.203028263242313 1.11599828340252 -0.181925246894923 0.855641390953914 1 FALSE VeillonellaVeillonella parvula (SP8) 1.03292574672193 1.41627116948218 0.729327666183865 0.465801252725255 1 FALSE HaemophilusHaemophilus parainfluenzae (SP83) -0.95661770575413 1.40259864733367 -0.682032388647068 0.495218470969363 1 FALSE CardiobacteriumCardiobacterium hominis (SP86) 0.978711439466593 0.73023454265999 1.34026998490305 0 0 TRUE CampylobacterCampylobacter concisus (SP88) -1.298590660573 1.26262110193104 -1.02848800688263 0.303720329466198 1 FALSE StreptococcusStreptococcus oralis (SP89) 1.56919260998031 1.54201268215977 1.01762626736796 0.308855599360311 1 FALSE PorphyromonasPorphyromonas pasteri (SP9) 0.418276195307468 1.28024769617876 0.326715054091427 0.743883413053853 1 FALSE ActinomycesActinomyces johnsonii (SP90) -0.36706081192013 1.04357819743755 -0.351732925066304 0.725038565813751 1 FALSE PrevotellaPrevotella loescheii (SP91) -0.247708037735524 1.09512203878553 -0.226192176727835 0.821051955017117 1 FALSE RothiaRothia dentocariosa (SP93) 0.467774227323172 1.30826002885833 0.35755447464934 0.720676752739596 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP97) -0.514744477529341 0.929758138977992 -0.55363266633531 0.579830265265363 1 FALSE ActinomycesActinomyces naeslundii_nov_97.422% (SPN109) -0.0879345821610062 1.11143644214655 -0.079117958370319 0.936938799574478 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN133) -0.603655670254257 1.51278942824103 -0.399034828631865 0.689867541502598 1 FALSE ActinomycesActinomyces israelii_nov_96.679% (SPN219) -0.585335352328045 0.921461832571481 -0.63522473925434 0.525281850492183 1 FALSE StreptococcusStreptococcus infantis_infantis_clade_638 (SPP31) -1.70050506736948 1.41365361502565 -1.20291494981154 0.229009234510005 1 FALSE VeillonellaVeillonella dispar_parvula (SPP45) 1.99947669060812 1.30267672616734 1.53489860565089 0.124808736095303 1 FALSE