Comp5OSS 12 Weeks P1...1 Comp5OSS 12 Weeks P1...2 Comp5OSS 12 Weeks P1...3 Comp5OSS 12 Weeks P1...4 Comp5OSS 12 Weeks P1...5 Comp5OSS 12 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mitis (SP1) 0.412364052136472 1.16704674309047 0.353339790867748 0.723833718093381 1 FALSE CorynebacteriumCorynebacterium durum (SP10) 0.660997041751355 0.846042212359432 0.781281397186998 0.434637008906824 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP100) 0.187203316244469 0.774339106611248 0.241758829750611 0.808967041778081 1 FALSE LachnoanaerobaculumLachnoanaerobaculum saburreum (SP101) -0.052632236612467 0.6602873723756 -0.0797111058221594 0.936467026393668 1 FALSE SolobacteriumSolobacterium moorei (SP106) -0.920216865086381 0.510902912574994 -1.80115799389048 0 0 TRUE PrevotellaPrevotella maculosa (SP107) -0.0298017243870445 0.582557384825111 -0.0511567189144658 0.959200639960584 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP111) 0.328495467347885 1.00533328138713 0.326752802707015 0.743854859542471 1 FALSE StreptococcusStreptococcus salivarius (SP115) 0.0213126534894952 1.39851322815052 0.0152395079721058 0.987841102512314 1 FALSE LeptotrichiaLeptotrichia hongkongensis (SP119) -0.126232889061952 0.951762060688731 -0.132630721769478 0.894485434598341 1 FALSE SelenomonasSelenomonas sputigena (SP12) -0.707011788988515 0.722535627472009 -0.9785147778279 0.327819786044523 1 FALSE OlsenellaOlsenella sp._HMT_807 (SP124) -0.619119039674174 1.023320145638 -0.605010115664417 0.545172275421244 1 FALSE SelenomonasSelenomonas noxia (SP128) 0.770357947646931 0.881714589066448 0.873704435879392 0.382279234608675 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP129) 0.574354178394102 0.674379031640259 0.8516785834772 0.394392510465826 1 FALSE ParvimonasParvimonas micra (SP13) -0.65825552808549 0.991748194565083 -0.663732519698873 0.506861521854782 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP130) 0.968303580767624 0.678178435742457 1.42780060487701 0.15334925869965 1 FALSE GemellaGemella haemolysans (SP131) 0.772440385022614 0.812555515217504 0.950630905281405 0.341791774287739 1 FALSE PrevotellaPrevotella micans (SP133) -0.40351740451833 0.592655839726018 -0.680862951936615 0.495958212336297 1 FALSE DialisterDialister invisus (SP134) -0.623881839820066 0.817008399853321 -0.763617411928779 0.445095269966141 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP136) -0.475695655569132 0.754522648734329 -0.630459080807033 0.528394266730857 1 FALSE LeptotrichiaLeptotrichia wadei (SP137) 0.5435409446539 0.928944924661518 0.585116437179472 0.558469427225715 1 FALSE TreponemaTreponema sp._HMT_237 (SP140) -0.684348843735401 0.676430831516629 -1.01170557557381 0.311678848852071 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP141) 0.266622381739466 0.751139196706778 0.354957353987675 0.72262154012423 1 FALSE GemellaGemella morbillorum (SP142) -0.577880679696102 0.615624372859866 -0.938690385196371 0.347889731341841 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP143) 0.670309105076227 0.637593570262128 1.05131095472097 0.293115797408561 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP144) 1.34973271082539 0.655836847785676 2.05803122435487 0 0 TRUE NeisseriaNeisseria mucosa (SP149) 0.796801002339929 0.807573060130649 0.986661197206136 0.323808758452272 1 FALSE CampylobacterCampylobacter showae (SP151) 0.0375380378824491 0.519350152431839 0.0722788617788568 0.942379986547488 1 FALSE PrevotellaPrevotella saccharolytica (SP154) -0.0754384389228136 0.541469823398558 -0.139321594044376 0.889196026709708 1 FALSE ScardoviaScardovia wiggsiae (SP158) -1.20258838635883 0.899917836013463 -1.33633131629679 0.181441004960026 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP159) 1.34532211857829 0.707045101887287 1.90273875738235 0.0570746419895306 1 FALSE Erysipelotrichaceae_[G-1]Erysipelotrichaceae_[G-1] bacterium_HMT_905 (SP166) 0.115504471579104 0.409801879192549 0.281854421474806 0.778055139516696 1 FALSE StreptococcusStreptococcus intermedius (SP167) 0.196561190285934 0.945516145558414 0.207887714249286 0.835316642221527 1 FALSE SelenomonasSelenomonas infelix (SP168) -0.0673219832475704 0.600104260419347 -0.112183811527228 0.910677664668069 1 FALSE FusobacteriumFusobacterium nucleatum (SP17) -2.00950020302856 1.02775542823617 -1.95523190422576 0.0505557044740615 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP174) 0.650783222208718 0.568291276664232 1.14515785994235 0.252143770996493 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP175) 0.525704303873607 0.705274830200108 0.745389288491195 0.456036417410665 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP176) 0.235368701490782 0.863152217411415 0.272685045282801 0.785095331342914 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP177) -0.0148343182458986 0.595876639589196 -0.0248949484848501 0.980138756512089 1 FALSE CatonellaCatonella morbi (SP18) -0.455414744637344 0.677153895455909 -0.672542457029988 0.501238420625173 1 FALSE StreptococcusStreptococcus australis (SP186) 0.266599024123713 0.769214892330334 0.346585884883289 0.728902451612662 1 FALSE PrevotellaPrevotella veroralis (SP19) 0.443418984537867 0.738663461590829 0.600299063910504 0.548306942478424 1 FALSE PrevotellaPrevotella pleuritidis (SP193) -0.578812710253489 0.704188024536109 -0.821957616553886 0.411101019330814 1 FALSE LautropiaLautropia mirabilis (SP194) 1.19154529113898 1.03946651077404 1.14630464645916 0.251669121044623 1 FALSE FusobacteriumFusobacterium periodonticum (SP195) 0.925547277013171 0.677763601913933 1.3655901178516 0.172067650024291 1 FALSE GranulicatellaGranulicatella adiacens (SP20) 0.694521899479417 0.976176492151574 0.711471649915102 0.476792012734449 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_132 (SP200) 0.03772678843502 0.5655325214735 0.0667102014517617 0.946812412821504 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP207) -0.774531480171576 0.832954023407058 -0.929861022825108 0.352443046114698 1 FALSE NeisseriaNeisseria flavescens (SP209) 1.37558785750906 0.590981318934389 2.32763340132207 0 0 TRUE LigilactobacillusLigilactobacillus salivarius (SP210) -0.0718412026904128 0.827274662314993 -0.0868408111151101 0.930798047560372 1 FALSE StreptococcusStreptococcus cristatus (SP214) 2.47706839674704 0.875072751415638 2.83069995350649 0.0046446269550905 0.575933742431222 FALSE NeisseriaNeisseria sicca (SP215) 1.67145432573348 0.773690755142806 2.16036486751734 0.0307444349469737 1 FALSE PeptococcusPeptococcus sp._HMT_167 (SP218) -0.0390664472456562 0.505781431862662 -0.0772397814245269 0.938432795157319 1 FALSE OribacteriumOribacterium sp._HMT_078 (SP220) -0.410488012301909 0.847364787836311 -0.484428923875941 0.628081495404881 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP223) 0.0651894379164067 0.53928697155352 0.120880795114734 0.903785453890046 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP226) 0.327515118462613 0.639038675331363 0.512512201695438 0.608292582941649 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP230) -0.140725751602089 0.749567299169834 -0.187742650670523 0.851078394308939 1 FALSE TreponemaTreponema sp._HMT_231 (SP231) -0.539230062160751 0.703726995825084 -0.766248936533309 0.443528195438596 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP232) -0.273389833988494 0.592423030572714 -0.461477390107875 0.644456139210958 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP24) 1.20518209046136 0.66945835508552 1.80023459458864 0.0718236034862566 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP244) -0.107384376708137 0.670388061628503 -0.160182412030548 0.872737383659608 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP25) -0.202380866514504 0.539095564383971 -0.375408146319598 0.707356947315155 1 FALSE KingellaKingella oralis (SP253) 2.70444387217716 0.795229158995588 3.40083589941923 0.000671801433599142 0.0846469806334919 FALSE ActinomycesActinomyces israelii (SP256) -0.864345716664138 0.638316983711856 -1.35410107943221 0 0 TRUE ArachniaArachnia propionica (SP258) -0.135383015487991 0.652902823900814 -0.207355536738431 0.83573220444847 1 FALSE GemellaGemella bergeri (SP263) -0.0345649255403735 0.662456217764489 -0.0521769206982698 0.958387722493461 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP264) -1.31044097494301 1.53150916348242 -0.85565336870938 0.392189540605726 1 FALSE RothiaRothia aeria (SP269) 2.12894922565979 0.737516795120664 2.8866450767558 0 0 TRUE AggregatibacterAggregatibacter sp._HMT_458 (SP27) 0.649839355603233 0.618771309805032 1.05020925389703 0.293621915853315 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP275) 0.582793963579491 1.0030109997119 0.58104443894124 0.561210503486905 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP276) -0.398820491743502 0.687232965120164 -0.580327941157141 0.561693488469924 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_348 (SP279) -0.124621141205494 0.584316689328289 -0.213276710183915 0.831111138230258 1 FALSE ActinomycesActinomyces naeslundii (SP3) 0.647585126459218 0.870033747970842 0.744321847249679 0.456681787167038 1 FALSE ActinomycesActinomyces oris (SP31) 0.838243932258119 0.976312841110562 0.858581283540848 0.390571567809534 1 FALSE PrevotellaPrevotella marshii (SP33) -0.064797387618589 0.55283740431793 -0.117208761767004 0.906694623893146 1 FALSE LancefieldellaLancefieldella parvula (SP338) -0.318279296628509 0.984740356320437 -0.323211387230829 0.746535157584921 1 FALSE StreptococcusStreptococcus gordonii (SP34) 0.0931083798490978 1.15829904122872 0.0803837148568551 0.935932078650189 1 FALSE LancefieldellaLancefieldella rimae (SP341) 0.00361081125909202 0.602889515058038 0.00598917574266392 0.995221357711507 1 FALSE FretibacteriumFretibacterium fastidiosum (SP345) 1.26052925985028 0.513738705443802 2.45363887613129 0 0 TRUE CorynebacteriumCorynebacterium matruchotii (SP35) 0.766344209721141 1.06873729304152 0.71705573924552 0.473339704498765 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP358) -0.0206556345125078 0.533482593557347 -0.0387184788444039 0.969114840468177 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP379) 0.0630908710380864 0.687170275037063 0.0918125729968217 0.926846954450391 1 FALSE NeisseriaNeisseria perflava (SP387) 0.839389029483761 0.801854479164436 1.04680967843247 0.295187365669772 1 FALSE StreptococcusStreptococcus parasanguinis_clade_411 (SP4) -0.701233370817693 1.29019312386475 -0.543510392240476 0.586778437610514 1 FALSE StreptococcusStreptococcus sanguinis (SP40) 1.03273118383114 1.12971994436033 0.91414796117094 0.36063910391385 1 FALSE StreptococcusStreptococcus mutans (SP41) 0.482079194503104 1.38441318017767 0.348219159861823 0.727675599682997 1 FALSE PrevotellaPrevotella oris (SP42) 0.408033348586279 0.88175558133164 0.462751081167029 0.643542799292397 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP428) -1.24142454269819 0.754836944943144 -1.64462610238519 0 0 TRUE SchaaliaSchaalia meyeri (SP43) -0.290629338962063 0.789245008848005 -0.368237157921683 0.712696405880735 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP44) -0.769732554382958 0.79114015239008 -0.97294082730797 0.330582712049777 1 FALSE OlsenellaOlsenella uli (SP464) 0.244991521628565 0.593297187963103 0.412932214409554 0.679656278108196 1 FALSE ActinomycesActinomyces dentalis (SP47) 1.16392553617139 0.942635790174034 1.23475635903502 0.216921193702365 1 FALSE EikenellaEikenella corrodens (SP48) -0.0797435919525278 0.551657690817512 -0.144552669671575 0.885064068748534 1 FALSE PrevotellaPrevotella denticola (SP49) -0.769892186974685 0.934406799272902 -0.823936841613061 0.409975445578635 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP5) -0.345152205842602 0.667995543348411 -0.516698366148498 0.605366736790983 1 FALSE TreponemaTreponema socranskii (SP51) 0.560399157849323 0.743393073027498 0.753839628296608 0.45094552531274 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP53) 0.566508153980731 1.25859440046493 0.450111770536607 0.652629850018635 1 FALSE PrevotellaPrevotella oulorum (SP57) 1.36792639956525 0.626295644808733 2.18415441797141 0 0 TRUE RothiaRothia mucilaginosa (SP59) 1.05368675292867 0.946513266608649 1.11322977722649 0.265609756964929 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP6) 1.382830054145 0.729578021473762 1.89538337702616 0.0580416293263241 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP62) -0.0582530431712416 0.703997205805993 -0.08274612838065 0.934053405466784 1 FALSE AlloprevotellaAlloprevotella tannerae (SP63) 1.33351465979298 0.557101248958485 2.39366661318031 0 0 TRUE VeillonellaVeillonella atypica (SP65) -0.55563731252389 0.857188022149666 -0.648209375500204 0.516849538806929 1 FALSE StreptococcusStreptococcus anginosus (SP69) -0.147815681763797 0.929030523452761 -0.159107454526292 0.873584215176117 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP74) 0.373675944081163 0.802368956419233 0.465715854397935 0.641418902414568 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP75) -1.02772146237051 0.576537808526746 -1.78257426862723 0 0 TRUE CampylobacterCampylobacter gracilis (SP78) -0.159288359929914 0.858530817034922 -0.185535983996524 0.852808659036904 1 FALSE PrevotellaPrevotella histicola (SP79) -0.210803216116132 0.738559322540476 -0.285424893684934 0.775318637988573 1 FALSE VeillonellaVeillonella parvula (SP8) 1.04681208433754 1.05465007763419 0.992568157474344 0.320920448976209 1 FALSE HaemophilusHaemophilus parainfluenzae (SP83) 2.45832145746082 1.00388330635484 2.44881197037446 0.0143328248523356 1 FALSE CardiobacteriumCardiobacterium hominis (SP86) 0.402318971087462 0.761170922043958 0.528552732948761 0.597115756924994 1 FALSE CampylobacterCampylobacter concisus (SP88) 1.25561767304385 0.661446182007307 1.89829151214298 0.0576576914655222 1 FALSE StreptococcusStreptococcus oralis (SP89) -0.0744013696385016 1.1891586327577 -0.0625663957599689 0.950111789267534 1 FALSE PorphyromonasPorphyromonas pasteri (SP9) 0.677903105969749 0.779015399941549 0.870205012661642 0.384188377063008 1 FALSE ActinomycesActinomyces johnsonii (SP90) 0.475348544166697 0.715774288705627 0.66410396638624 0.506623771718448 1 FALSE MogibacteriumMogibacterium neglectum (SP92) -0.396733058928593 0.689198706052648 -0.57564394048396 0.564855874306032 1 FALSE RothiaRothia dentocariosa (SP93) -0.431371908201055 0.840636052740924 -0.513149426311841 0.607846799569022 1 FALSE AlloprevotellaAlloprevotella rava (SP96) 0.0724363671262492 0.50565597720354 0.143252271093182 0.886090949113245 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP97) -0.569348272446945 0.813453671371357 -0.699914810744062 0.483980507392872 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP98) -0.95001434693501 0.926820323391889 -1.02502537218674 0.305351216071848 1 FALSE ActinomycesActinomyces naeslundii_nov_97.422% (SPN109) 1.15083664728371 0.796388502722753 1.4450693893108 0.148438396079178 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN133) 0.860438841034269 1.08176603941558 0.795401972037424 0.426379713182182 1 FALSE ActinomycesActinomyces israelii_nov_96.679% (SPN219) -0.37944414676759 0.6991236391348 -0.542742550140589 0.587307073323363 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN249) -0.423255414440724 0.675466799017065 -0.626611722525286 0.530913782305795 1 FALSE FusobacteriumFusobacterium nucleatum_nov_97.018% (SPN283) -0.145182339432956 0.615988180678584 -0.235690138198788 0.813673122921233 1 FALSE StreptococcusStreptococcus infantis_infantis_clade_638 (SPP31) 1.14395411132849 0.749945160790498 1.52538368288513 0.127163426203809 1 FALSE VeillonellaVeillonella dispar_parvula (SPP45) -0.493368424199534 1.01380904000438 -0.486648278651571 0.626507604029349 1 FALSE