Comp6OSS 24 Weeks P1...1 Comp6OSS 24 Weeks P1...2 Comp6OSS 24 Weeks P1...3 Comp6OSS 24 Weeks P1...4 Comp6OSS 24 Weeks P1...5 Comp6OSS 24 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mitis (SP1) -0.33393033722072 1.06351805872721 -0.313986522824408 0.753531274759219 1 FALSE CorynebacteriumCorynebacterium durum (SP10) 0.50258032731868 1.07267553427142 0.468529682333104 0.639405849646611 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP100) -0.348067115132841 1.12580628514092 -0.309171408728876 0.757191141693328 1 FALSE LachnoanaerobaculumLachnoanaerobaculum saburreum (SP101) 2.12413217586616 1.02471778048235 2.07289481682098 0.0381820695177194 1 FALSE PrevotellaPrevotella intermedia (SP104) 0.455639212156468 0.673471021305457 0.676553552776861 0.498689257206768 1 FALSE SolobacteriumSolobacterium moorei (SP106) -1.12700524054826 0.723596330922088 -1.55750546594411 0.119350523860243 1 FALSE PrevotellaPrevotella maculosa (SP107) -0.0550799803574079 0.694232280853864 -0.0793394111401199 0.936762659529111 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP111) -0.749941263199993 0.704451235847038 -1.06457512605292 0.287068240954998 1 FALSE StreptococcusStreptococcus salivarius (SP115) -0.237821571856893 1.04672285939247 -0.227205864210253 0.820263667953301 1 FALSE LeptotrichiaLeptotrichia hongkongensis (SP119) -0.326823336195376 1.16204174386105 -0.281249221830412 0.778519254028053 1 FALSE SelenomonasSelenomonas sputigena (SP12) -0.266231286409724 0.966947336384234 -0.275331733582575 0.783061386379555 1 FALSE OlsenellaOlsenella sp._HMT_807 (SP124) 0.0119974538273263 1.06760229842184 0.0112377557120861 0.991033756939868 1 FALSE SelenomonasSelenomonas noxia (SP128) 1.50241435126428 1.0152290989446 1.47987715563526 0.138906033197239 1 FALSE ParvimonasParvimonas micra (SP13) -1.82986293602269 1.04737743689195 -1.74709027669408 0.0806216797552189 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP130) 1.28428294278601 0.871190471791122 1.47417009755122 0.140435798800728 1 FALSE GemellaGemella haemolysans (SP131) -0.782223404231779 0.773693359079403 -1.0110250980602 0.312004417553332 1 FALSE DialisterDialister invisus (SP134) -1.40436129579662 1.00975948608981 -1.39078792043328 0.164289747172679 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP136) -0.293787850295246 1.13754874228179 -0.258263966523265 0.796203193667846 1 FALSE LeptotrichiaLeptotrichia wadei (SP137) 0.566318450183825 1.26311432835457 0.448350903375116 0.653899968946768 1 FALSE TreponemaTreponema sp._HMT_237 (SP140) 0.0501329201079557 0.806903354740103 0.0621300181904723 0.950459292109636 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP141) -0.345082385151998 0.687013769344019 -0.502293258956793 0.615461250346634 1 FALSE GemellaGemella morbillorum (SP142) -0.354059610507684 0.83497645487702 -0.424035442484222 0.671539965518551 1 FALSE StomatobaculumStomatobaculum longum (SP145) -0.102365744862891 0.796982581137242 -0.128441633839502 0.897799484955602 1 FALSE PrevotellaPrevotella salivae (SP147) 0.0980572312647058 0.752491401919335 0.13031010190229 0.896321088057001 1 FALSE NeisseriaNeisseria mucosa (SP149) -1.37698449212489 0.85846657457601 -1.60400478353508 0 0 TRUE CampylobacterCampylobacter showae (SP151) 0.752812837243239 0.659030206462032 1.14230399435661 0.253327681512853 1 FALSE PrevotellaPrevotella saccharolytica (SP154) -0.290469186188619 0.745955053817432 -0.38939234301335 0.696985935368529 1 FALSE PorphyromonasPorphyromonas endodontalis (SP156) 0.882440748508165 0.753128885511952 1.1716995131694 0.241317718562569 1 FALSE ScardoviaScardovia wiggsiae (SP158) 0.156768992122458 0.957680856287025 0.163696487293543 0.869970082979914 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP159) 2.66638916378639 0.857975447807341 3.10776860876458 0.0018850559584317 0.237517050762394 FALSE StreptococcusStreptococcus intermedius (SP167) -0.729852423477843 1.02921257459754 -0.709136714311176 0.478239641424216 1 FALSE SelenomonasSelenomonas infelix (SP168) -0.436321708976681 0.693944985921072 -0.628755474610933 0.529509153902471 1 FALSE FusobacteriumFusobacterium nucleatum (SP17) -0.648083417422976 0.88600305734362 -0.731468601661528 0.464492976105262 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP174) 0.0556007739348495 0.721708851325871 0.0770404489742696 0.938591366940599 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP175) -0.660272294615422 0.805366314514501 -0.819840962697146 0.412306775910536 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP176) 0.546678313131164 0.99132420426895 0.551462690789751 0.581316535733623 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP177) 0.210530784455776 0.820658110621651 0.256538967605277 0.797534695093777 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP179) -0.345888137735788 0.589763686789159 -0.586485986648145 0.557548975849692 1 FALSE CatonellaCatonella morbi (SP18) -0.359520578588397 0.937009900996055 -0.383689199234951 0.701208818805413 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP184) 0.49399339753735 0.881382755129028 0.560475451400264 0.575155179483997 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP185) 0.209554393719028 0.568477375841423 0.368623981576856 0.712408017816792 1 FALSE StreptococcusStreptococcus australis (SP186) 0.506124840713606 0.782336501715262 0.646940082181944 0.517670723196707 1 FALSE PrevotellaPrevotella veroralis (SP19) -0.7577180450106 0.707589049123573 -1.07084478759121 0.284239224884965 1 FALSE PrevotellaPrevotella pleuritidis (SP193) 0.0855274678701394 0.813392822762278 0.1051490319028 0.916257553081363 1 FALSE LautropiaLautropia mirabilis (SP194) 0.329683490247486 1.04901648678319 0.314278654722065 0.753309408579276 1 FALSE GranulicatellaGranulicatella adiacens (SP20) -0.0660574078167923 1.10226205129787 -0.0599289504152052 0.952212222230035 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP207) -2.16770418347296 0.855318715227706 -2.53438179812992 0.011264592349565 1 FALSE StreptococcusStreptococcus cristatus (SP214) 1.65972784396804 0.93074700236773 1.78322126178849 0.0745502927211593 1 FALSE PeptococcusPeptococcus sp._HMT_167 (SP218) -0.272831804527422 0.80244805187767 -0.33999933564424 0.733857028237265 1 FALSE OribacteriumOribacterium sp._HMT_078 (SP220) -0.108472264805773 0.912148489642 -0.118919524658036 0.905339113086611 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP226) 0.678422911119 0.84442318132745 0.803415782655927 0.421734455780491 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP230) -0.157378867086616 0.974082217213286 -0.161566307551384 0.871647391336252 1 FALSE TreponemaTreponema sp._HMT_231 (SP231) -0.151627222826629 0.848269973184871 -0.178748780010847 0.858134965041344 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP232) 0.210592596175696 0.886095450029215 0.237663556639133 0.812142051421401 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP24) 0.207446003073466 0.851114184212514 0.243734632698436 0.807436349077973 1 FALSE LeptotrichiaLeptotrichia hofstadii (SP241) 0.494471771979615 0.768796061384283 0.643176775761931 0.520109401106994 1 FALSE PeptoanaerobacterPeptoanaerobacter [Eubacterium] yurii (SP243) -0.215391791099634 0.667802153250517 -0.322538329730172 0.747044904984785 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP244) -0.0860883909480933 0.744229641146026 -0.115674499090801 0.907910517333428 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP25) -0.487309128896714 0.811963443376133 -0.60016141474361 0.548398665982009 1 FALSE KingellaKingella oralis (SP253) 2.78856551194835 1.00191973525398 2.78322246166901 0.00538218883147605 0.667391415103031 FALSE ActinomycesActinomyces israelii (SP256) -0.333586773497983 0.908026602207026 -0.367375551208715 0.713338905857414 1 FALSE ArachniaArachnia propionica (SP258) -0.580880127029657 0.969571179832051 -0.599110348071894 0.54909930151545 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP264) 0.105805475618577 1.68916756162159 0.0626376435485204 0.950055053041066 1 FALSE LeptotrichiaLeptotrichia sp._HMT_212 (SP272) 0.482118990018287 0.70465232771614 0.684194135256589 0.493852585123277 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP275) -1.90321434924286 0.836637363881702 -2.27483785855872 0 0 TRUE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP276) -0.909108927143305 0.784475477084997 -1.15887488353547 0.246507188107511 1 FALSE TannerellaTannerella sp._HMT_286 (SP28) 0.712430563792272 0.818424626930229 0.870490134765956 0.384032608128258 1 FALSE ActinomycesActinomyces naeslundii (SP3) 0.557930068158923 0.889660693685667 0.627126804768166 0.530576117843734 1 FALSE PrevotellaPrevotella melaninogenica (SP30) 0.223786046202303 0.766453662647421 0.291975962942521 0.770305002384943 1 FALSE TreponemaTreponema sp._HMT_951 (SP305) 0.393234010904949 0.582106923015634 0.675535705481358 0.499335474384078 1 FALSE ActinomycesActinomyces oris (SP31) 0.210045328009798 1.11307361625766 0.188707489731009 0.850322081104366 1 FALSE CatonellaCatonella sp._HMT_451 (SP323) 0.411002421412024 0.603017263040484 0.681576542833453 0.495506751653225 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP335) -0.356560394921394 0.773228405763404 -0.461132043602775 0.644703873287324 1 FALSE LancefieldellaLancefieldella parvula (SP338) -0.527111322879794 0.918247739514186 -0.574040425254595 0.565940445879339 1 FALSE StreptococcusStreptococcus gordonii (SP34) -0.12603209692982 1.18997350331095 -0.105911683393918 0.915652424200949 1 FALSE LancefieldellaLancefieldella rimae (SP341) -1.13844431432408 0.848592138534286 -1.3415683019294 0.17973600970202 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP35) 1.32635195857932 0.957723520807913 1.38490068350878 0.166082838011087 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP36) -0.0489985621308537 0.650127748194283 -0.0753675908572528 0.939922244596148 1 FALSE ActinomycesActinomyces massiliensis (SP360) -0.0907510302436284 0.913978439917166 -0.0992923096214974 0.920906184277057 1 FALSE SelenomonasSelenomonas sp._HMT_919 (SP369) -0.3242855098225 0.734134677950295 -0.441724821837739 0.658688345549781 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_338 (SP399) 0.285353976449115 0.632100787387167 0.451437463997863 0.651674287033785 1 FALSE StreptococcusStreptococcus parasanguinis_clade_411 (SP4) 0.333136985537768 1.38916239785167 0.239811404377891 0.810476465505778 1 FALSE StreptococcusStreptococcus sanguinis (SP40) 0.848525056893206 1.22866503120062 0.690607313910487 0.489812349943094 1 FALSE StreptococcusStreptococcus mutans (SP41) 1.5957358435437 1.49269685091589 1.06902874657007 0.285056716357948 1 FALSE PrevotellaPrevotella oris (SP42) -1.02736267423777 0.901908977549942 -1.13909795756621 0.254662299298103 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP428) -1.40405922296632 1.13941738668857 -1.2322606617816 0.217851729539804 1 FALSE SchaaliaSchaalia meyeri (SP43) -0.912496828095227 0.848803339398525 -1.07503915894327 0.282357196748409 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP44) -1.40035563715232 0.89774579133981 -1.55985764640836 0.11879352515568 1 FALSE ActinomycesActinomyces dentalis (SP47) 2.60518644383957 1.08481399046158 2.40150520434483 0.016327776810551 1 FALSE EikenellaEikenella corrodens (SP48) 0.655989480645504 0.654273806296315 1.00262225742904 0.316043152648375 1 FALSE PrevotellaPrevotella denticola (SP49) -0.0632431979421871 1.06391396380517 -0.0594439025088016 0.952598545715978 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP5) -0.329411745153983 0.825033468429678 -0.399270766288992 0.689693705077232 1 FALSE TreponemaTreponema socranskii (SP51) 0.458941630609444 0.896717431374556 0.511801839188008 0.608789703037587 1 FALSE SchaaliaSchaalia odontolytica (SP52) -0.0898529913772185 0.934069682880048 -0.0961951694012505 0.923365567284019 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP53) 0.532721873823873 1.32389897823383 0.402388613166362 0.687398048833796 1 FALSE PrevotellaPrevotella oulorum (SP57) 0.832485702530601 0.850603742392144 0.978699788210912 0.327728336765771 1 FALSE RothiaRothia mucilaginosa (SP59) -0.228625507909519 1.09816156254851 -0.208189319046049 0.835081148048087 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP6) 0.979537496269918 0.987746124244443 0.991689536639991 0.321348996768888 1 FALSE SelenomonasSelenomonas flueggei (SP60) 0.444339951423092 0.685910193619243 0.647810683609334 0.517107404546333 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP62) -0.0252253810813178 0.872064149984931 -0.0289260613244492 0.976923560384231 1 FALSE AlloprevotellaAlloprevotella tannerae (SP63) 0.903782152918186 0.790442605574003 1.1433874471656 0.252877761977074 1 FALSE VeillonellaVeillonella atypica (SP65) -0.514596671277915 0.81078330117025 -0.634690762050931 0.525630119821588 1 FALSE StreptococcusStreptococcus anginosus (SP69) 0.0517132666275233 1.15599329844209 0.0447349190494585 0.964318600171832 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP74) 1.14898744743926 1.22479200576047 0.938108219220342 0.348188798336211 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP75) -0.764859339479312 0.831956165318247 -0.919350527544599 0.357912257133537 1 FALSE CardiobacteriumCardiobacterium valvarum (SP77) 0.41604032964814 0.819683011711546 0.507562464640353 0.611760219679134 1 FALSE CampylobacterCampylobacter gracilis (SP78) 0.768411582146706 0.947547292201849 0.810948000665087 0.417395533150832 1 FALSE PrevotellaPrevotella histicola (SP79) -0.499835578656815 0.877049798979972 -0.569905584880282 0.568741736740971 1 FALSE VeillonellaVeillonella parvula (SP8) 0.156887562713054 0.951481321110698 0.164887695882367 0.869032377103053 1 FALSE HaemophilusHaemophilus parainfluenzae (SP83) 1.00490263978862 1.28677822453526 0.780944704089591 0.434835017745963 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP84) -0.345813649836627 0.804404133944052 -0.429900388677862 0.667268102727878 1 FALSE CardiobacteriumCardiobacterium hominis (SP86) 0.442514718626801 0.881771508197307 0.501847377141361 0.615774883897242 1 FALSE CampylobacterCampylobacter concisus (SP88) -0.453072658674678 0.727500295144072 -0.622780034178478 0.533429080422025 1 FALSE StreptococcusStreptococcus oralis (SP89) 1.28113997439372 1.21675358095565 1.05291654320631 0.292379243363346 1 FALSE PorphyromonasPorphyromonas pasteri (SP9) 0.20807264426708 0.976507413398048 0.213078407201261 0.831265806462623 1 FALSE ActinomycesActinomyces johnsonii (SP90) 0.783110680872882 0.797380770994655 0.982103794522192 0.326048716295827 1 FALSE PrevotellaPrevotella loescheii (SP91) -0.456525556324449 0.768972782476941 -0.593682334053402 0.55272460093413 1 FALSE MogibacteriumMogibacterium neglectum (SP92) -1.84208119165424 0.642455399158231 -2.86725147623913 0 0 TRUE RothiaRothia dentocariosa (SP93) -0.60923887678278 1.03158426102154 -0.590585664984337 0.554798072092886 1 FALSE MegasphaeraMegasphaera micronuciformis (SP95) 0.359040583840627 0.665191363934316 0.539755329529625 0.589365777142128 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP97) -0.441238611357328 0.898937692527358 -0.490844487916385 0.623536441984769 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN133) -0.0434667871273337 1.01751595039225 -0.0427185314496321 0.965925907092839 1 FALSE AlloprevotellaAlloprevotella rava_nov_97.244% (SPN203) -0.00274807435540431 0.697859120901729 -0.00393786406610752 0.996858047179373 1 FALSE ActinomycesActinomyces israelii_nov_96.679% (SPN219) -0.54038664834719 0.705177777838366 -0.766312645307226 0.44349029594262 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN249) -1.15277097320842 0.700758342999986 -1.64503353363349 0 0 TRUE VeillonellaVeillonella dispar_parvula (SPP45) 0.419916545756745 0.412115340666518 1.01892966439349 0.308236359388668 1 FALSE