Comp5OSS 12 Weeks P1...1 Comp5OSS 12 Weeks P1...2 Comp5OSS 12 Weeks P1...3 Comp5OSS 12 Weeks P1...4 Comp5OSS 12 Weeks P1...5 Comp5OSS 12 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) 0.472506977143822 1.38493881376332 0.341175344678131 0.732971583064522 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 0.895546266512405 0.912351501017715 0.981580307056476 0.326306653156109 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) 1.32917721601752 0.858407107409235 1.54842289229073 0.121520513131186 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) 1.11816569966135 0.757303322747684 1.47650969707141 0.139807113975785 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) 0.318923249988605 1.00523498560444 0.317262385965246 0.751044515810825 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) 0.0535186536788059 0.688684965976062 0.0777113721408958 0.938057647804844 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP115) -0.0678252605305225 0.716646512583324 -0.0946425599505537 0.924598743585737 1 FALSE VeillonellaVeillonella atypica (SP116) -0.56520952988317 0.854172999639033 -0.661703811899958 0.508161061269937 1 FALSE CatonellaCatonella morbi (SP118) -0.464986961996625 0.674876601037615 -0.688995530859587 0.490826079986836 1 FALSE PrevotellaPrevotella oris (SP12) 0.398461131226999 0.884752441894249 0.450364545334169 0.652447605296696 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 1.37325783678572 0.724568942983588 1.89527559811079 0.0580558992454559 1 FALSE CampylobacterCampylobacter showae (SP122) 0.0279658205231687 0.516395699952461 0.0541557966608614 0.956811038124175 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 1.25095704249099 0.499859260212927 2.50261852097752 0 0 TRUE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) 0.958731363408344 0.681039857820922 1.40774633437158 0.159206196405742 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) -0.831471681713482 1.03863638993691 -0.800541642647419 0.423397046564183 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.433846767178586 0.741334461952777 0.585224064770676 0.558397065784731 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.784103697530856 0.836735879945029 -0.937098212619219 0.348708040770683 1 FALSE PeptococcusPeptococcus sp._Oral_Taxon_167 (SP133) -0.0486386646049369 0.499172659781289 -0.0974385588871148 0.922378124833824 1 FALSE PrevotellaPrevotella saccharolytica (SP137) -0.0850106562820946 0.531571638821132 -0.15992323531523 0.872941544949669 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.641211004849437 0.56453057977513 1.13583041879654 0.256027543643259 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 2.44874924010153 1.00368985647696 2.43974692411146 0.0146975543214504 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.420060229661189 0.84758497496109 -0.495596597474457 0.620179053885102 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.759911545064008 0.592326389507774 1.28292704583954 0.199517636425272 1 FALSE Erysipelotrichaceae_[G-1]Erysipelotrichaceae_[G-1] bacterium_HMT_905 (SP145) 0.105932254219823 0.410227384292325 0.258228139505033 0.796230842001026 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.864798489517297 1.06635863590804 -0.810982778585452 0.417375560598873 1 FALSE StreptococcusStreptococcus cristatus (SP15) 2.46749617938776 0.867342927678109 2.84489110436778 0.00444266083351508 0.59928929697225 FALSE StreptococcusStreptococcus sp._str._C150 (SP154) -0.676222904968582 1.36086694961646 -0.49690596509759 0.619255364829003 1 FALSE SelenomonasSelenomonas infelix (SP156) -0.0768942006068509 0.593481048410811 -0.129564711144111 0.896910824274704 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.257050164380185 0.742776091533662 0.346066825938669 0.729292493881706 1 FALSE PrevotellaPrevotella marshii (SP16) -0.0743696049778697 0.545776463630249 -0.13626385513805 0.891612696737555 1 FALSE ScardoviaScardovia wiggsiae (SP166) -1.21216060371811 0.900612260306134 -1.3459294939046 0.17832525594032 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 1.02315896647186 1.12928339510063 0.906024980895684 0.364922630326805 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.300967905995708 0.709954632029782 -0.423925547376501 0.671620111942541 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 0.364103726721882 0.80995949227751 0.449533254679275 0.653047024455095 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.638012909099938 0.871048687151916 0.732465266879698 0.463884634998149 1 FALSE FusobacteriumFusobacterium periodonticum (SP173) 0.915975059653891 0.678155583310901 1.35068571607404 0.176796129817429 1 FALSE PrevotellaPrevotella histicola (SP174) -0.220375433475412 0.738004240242165 -0.298609982786954 0.765237647637253 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.157387899123077 0.937598814460628 -0.167862732648204 0.866691269083323 1 FALSE KingellaKingella oralis (SP176) 2.69487165481788 0.792832509360208 3.39904282809059 0.000676221264677905 0.091966091996195 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.135805106421233 0.944117366742693 -0.143843457609275 0.885624085484216 1 FALSE GemellaGemella haemolysans (SP183) 0.762868167663333 0.802881940752365 0.950162320189272 0.342029781147947 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.668330888610469 0.772161896045117 0.865532075635365 0.386746818617618 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.628691257033454 1.02708279955834 -0.612113509547428 0.540462659943246 1 FALSE LactobacillusLactobacillus salivarius (SP190) -0.0814134200496937 0.823084526951178 -0.0989125872056671 0.921207674773543 1 FALSE RothiaRothia dentocariosa (SP193) -0.440944125560337 0.836456352653683 -0.527157363515057 0.598084314180761 1 FALSE EikenellaEikenella corrodens (SP200) -0.0893158093118084 0.550809662273855 -0.162153672001857 0.871184841270203 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 1.82323510890682 1.10355329928174 1.65214957002393 0.0985040639267424 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.225796484131502 0.861535260594908 0.262086178545478 0.793255002366625 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.168860577289195 0.856244565567215 -0.197210684983833 0.843662669405753 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.716584006347796 0.724001398297453 -0.989755003281624 0.322293883212034 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.15029796896137 0.751608947711457 -0.199968307214817 0.84150536766454 1 FALSE NeisseriaNeisseria sicca (SP215) 1.23006681251652 0.700624232794094 1.75567266294945 0.079144317173245 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.000372720218476452 0.612334877787166 -0.000608686899925373 0.999514338150176 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.136924738004104 0.655397325122659 -0.208918670790239 0.834511728582888 1 FALSE StreptococcusStreptococcus australis (SP219) 0.579449289072176 0.701221808513114 0.826342367047671 0.408609906551017 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP220) 0.660736887716947 0.633780877781833 1.04253206570299 0.29716506691309 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.588384927612771 0.705706930077966 -0.833752514726994 0.404420458783413 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.75677199236186 1.06738110237047 0.708998867116161 0.478325179864616 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) 1.93794118409255 0.852110821623394 2.27428303328021 0.0229489746198314 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.392746753728182 0.766698280336918 0.512257251386547 0.608470979379088 1 FALSE LautropiaLautropia mirabilis (SP245) 1.1819730737797 1.03998905764407 1.1365245288804 0.255737105797482 1 FALSE ActinomycesActinomyces oris (SP249) 0.282787387863302 0.908030810771428 0.311429286879656 0.755474292402425 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_132 (SP250) 0.0281545710757394 0.561108345525573 0.0501767106125785 0.959981570409814 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.465776326807416 0.715446582151525 0.651028795758184 0.515027898688517 1 FALSE ArachniaArachnia propionica (SP260) -0.144955232847272 0.651939989483182 -0.222344441490977 0.824045758507339 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 0.278013498701636 1.04855024943357 0.26514084456307 0.790900963528967 1 FALSE MogibacteriumMogibacterium neglectum (SP265) -0.406305276287874 0.700171942230761 -0.580293570452677 0.561716662515976 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 1.33574990121901 0.704186439933923 1.89686967182207 0.0578451410875988 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 1.3239424424337 0.546007018692092 2.42477183829079 0 0 TRUE SolobacteriumSolobacterium moorei (SP279) -0.929789082445662 0.519926173995984 -1.78830981964152 0 0 TRUE DialisterDialister invisus (SP28) -0.633454057179347 0.819873823972148 -0.772623833885037 0.439745034942651 1 FALSE ActinomycesActinomyces dentalis (SP286) 1.15435331881211 0.933894329190179 1.23606416992927 0.216434711961467 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.578920489806226 0.805839234902085 -0.718406928742515 0.472506415875271 1 FALSE ActinomycesActinomyces israelii (SP293) -0.873917934023418 0.637184837263887 -1.37152970835916 0 0 TRUE FretibacteriumFretibacterium sp._HMT_360 (SP294) 0.0556172205571258 0.528642042801153 0.105207713450907 0.916210990244195 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.317942901103333 0.633309370753126 0.502034101793311 0.615643533114467 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP301) -0.0302278518717881 0.523472993544619 -0.057744816341154 0.953951894952622 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_348 (SP304) -0.134193358564775 0.578053351413919 -0.23214701244537 0.816423831440056 1 FALSE ParvimonasParvimonas micra (SP31) -0.66782774544477 0.992746547662273 -0.672707195021101 0.501133589277351 1 FALSE RothiaRothia mucilaginosa (SP318) 1.04411453556939 0.949178879223984 1.10001871978338 0.271323965685617 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.640267138243953 0.616998956683864 1.03771186532494 0.299404219252702 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) -0.0244065356051802 0.592856886713769 -0.0411676682048287 0.967162228846356 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 1.19560987310208 0.67010814665388 1.78420435428556 0.0743904650376412 1 FALSE GemellaGemella morbillorum (SP332) -0.242191669856088 0.56818157604909 -0.426257520597893 0.669920207837123 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.564781961034821 0.669549477049743 0.843525356069931 0.398934690895594 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.282962051347774 0.582864682949074 -0.485467827482862 0.627344528960339 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -1.3200131923023 1.53006878456732 -0.862714935182194 0.388294218758348 1 FALSE PrevotellaPrevotella micans (SP370) -0.413089621877611 0.586087083856565 -0.704826353038531 0.480918306429977 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.758860406188901 1.04095726604314 0.729002458548043 0.466000158587547 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.548802279520032 0.703829866763665 -0.779737128865421 0.435545619627689 1 FALSE OlsenellaOlsenella uli (SP417) 0.235419304269285 0.590229664115611 0.398860509022421 0.689995988901729 1 FALSE AlloprevotellaAlloprevotella rava (SP42) 0.0628641497669684 0.496544048357354 0.126603369781458 0.899254329706024 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -1.25099676005747 0.761895483315731 -1.6419532435252 0 0 TRUE NeisseriaNeisseria mucosa (SP44) 0.787228784980648 0.808037412105393 0.974247940982674 0.329933446166146 1 FALSE GemellaGemella bergeri (SP450) -0.0441371428996543 0.65794584136108 -0.0670832462567871 0.946515431398247 1 FALSE RothiaRothia aeria (SP465) 2.1193770083005 0.74491112346561 2.84514077121087 0 0 TRUE LeptotrichiaLeptotrichia wadei (SP49) 0.53396872729462 0.923655740050041 0.578103620365842 0.56319416294441 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.710805588176975 1.28242950282724 -0.554264843884154 0.579397606515567 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.85296710458269 1.0404343857905 -0.819818256904901 0.412319721671679 1 FALSE StreptococcusStreptococcus mitis (SP52) 0.451679295221067 1.04719990776763 0.431320984532872 0.666234994250141 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.0393739417463251 0.581754860687242 -0.0676813283516216 0.946039313040973 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 1.58927296601139 1.15966243131404 1.3704617163553 0.170542818127634 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP563) 1.30871930753766 0.640538442782925 2.04315497732144 0 0 TRUE StreptococcusStreptococcus oralis (SP58) -0.16454761582996 1.12446052987831 -0.146334719145515 0.883657158938006 1 FALSE PrevotellaPrevotella denticola (SP60) -0.779464404333965 0.937191605813734 -0.831702289583761 0.405577007983021 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.177631098885188 0.774710086630742 0.229287190073536 0.818645709140651 1 FALSE TreponemaTreponema socranskii (SP63) 0.550826940490042 0.731089284513295 0.753433201878676 0.451189637430852 1 FALSE StreptococcusStreptococcus gordonii (SP64) 1.35109110125176 1.07011967450308 1.26256075226273 0.206747080216324 1 FALSE CampylobacterCampylobacter concisus (SP67) 1.24604545568457 0.660908491012177 1.8853524695624 0.0593822665844107 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.651424824392075 0.84028503057627 0.775242686336238 0.438196269053415 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) -0.485267872928413 0.754674400893969 -0.643016209843048 0.520213581783404 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) -1.03729367972979 0.572315299110966 -1.8124514255361 0 0 TRUE TreponemaTreponema sp._HMT_237 (SP70) -0.693921061094682 0.675910101971412 -1.02664697431025 0.304586726312106 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.95958656429429 0.923576934899793 -1.03898931213392 0.298809706977108 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.76078573028765 0.883948592971644 0.860667392127468 0.389421257190866 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.294491348134554 0.784896084661515 -0.37519788146421 0.707513305654764 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -1.22791262146387 1.03355916568773 -1.18804289316792 0.23481651121598 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.408392709102783 0.687763123788239 -0.593798496862309 0.55264689454061 1 FALSE StreptococcusStreptococcus infantis (SP87) 1.1038006722643 0.781219214357753 1.41292053751102 0.157679089712482 1 FALSE VeillonellaVeillonella parvula (SP88) -0.0735798192233003 0.976722022823375 -0.0753334290657292 0.939949424492906 1 FALSE PrevotellaPrevotella oulorum (SP9) 1.35835418220597 0.627572312214919 2.16445843095255 0 0 TRUE StreptococcusStreptococcus intermedius (SP94) 0.186988972926653 0.95069504973846 0.196686595747074 0.844072800242113 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.516132086514326 0.708438158393912 0.728549246534716 0.466277434076886 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.116956594067419 0.667194547789775 -0.175296087857527 0.86084698561495 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.295465752413831 0.587771204296854 -0.502688376453035 0.615183383144036 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.779304771742238 0.795097720041295 -0.9801370977416 0.327018449154069 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) 1.13154468794728 0.787096991814628 1.43761785359964 0.150542512380108 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.432827631800005 0.681269440942522 -0.635325182355452 0.525216352930334 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.760402753355421 1.07197154429366 0.709349755973668 0.478107458942089 1 FALSE ActinomycesActinomyces israelii_nov_96.679% (SPN522) -0.389016364126871 0.697195681393574 -0.557972997407692 0.576862823153005 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nov_97.416% (SPN547) -0.154754556792237 0.609658990919148 -0.253837898066462 0.79962079367737 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.32785151398779 0.981077131312489 -0.334175064858752 0.738247458837214 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.532122694741676 0.804916128659387 -0.661090858780458 0.508554047226306 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) -0.178609164811095 0.678739350016368 -0.263148386500337 0.792436210695204 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.062204453971748 0.654682080214008 -0.0950147496803548 0.924303111373551 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -1.6060703179194 0.793624329856353 -2.02371608013845 0.0429993731081843 1 FALSE