Comp6OSS 24 Weeks P1...1 Comp6OSS 24 Weeks P1...2 Comp6OSS 24 Weeks P1...3 Comp6OSS 24 Weeks P1...4 Comp6OSS 24 Weeks P1...5 Comp6OSS 24 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) 1.59801475389375 1.49271788186154 1.07054037022782 0.284376147650875 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.100086834512844 0.797056890830776 -0.12557050276364 0.90007191347951 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -1.17921303929423 0.88335875828647 -1.33491973474249 0.181902618000191 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.618705525557447 0.767265920467611 -0.806376914512737 0.420025553826615 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.747662352849948 0.709520865549244 -1.05375668166035 0.291994330744103 1 FALSE PrevotellaPrevotella salivae (SP111) 0.100336141614752 0.744797705909074 0.134715964910614 0.892836450086692 1 FALSE ActinomycesActinomyces sp._HMT_896 (SP115) -0.0229464707312711 0.880310633440784 -0.0260663337003922 0.979204429748425 1 FALSE VeillonellaVeillonella atypica (SP116) -0.512317760927869 0.808777364024507 -0.633447205271122 0.526441646932095 1 FALSE CatonellaCatonella morbi (SP118) -0.357241668238351 0.931907849469726 -0.383344413765405 0.701464412350676 1 FALSE PrevotellaPrevotella oris (SP12) -1.02508376388772 0.902322178370286 -1.13605072385471 0.255935336152579 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.981816406619964 0.981172554634172 1.00065620668123 0.316993046445061 1 FALSE CampylobacterCampylobacter showae (SP122) 0.755091747593286 0.653861323481484 1.15481940967666 0.248164386991062 1 FALSE LeptotrichiaLeptotrichia sp._HMT_212 (SP125) 0.484397900368333 0.699276769322557 0.692712702064458 0.488489866171042 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.0467196517808071 0.658799797925948 -0.070916311644131 0.943464361246074 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) 1.28656185313606 0.868247345403307 1.48179186489587 0.138395684366308 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.019148492944834 1.14667018943617 0.016699215800011 0.986676572775476 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.755439134660555 0.712128639216742 -1.06081835929454 0.288772457026248 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -2.16542527312292 0.861161581920229 -2.51454003358397 0.0119187769915255 1 FALSE PeptococcusPeptococcus sp._Oral_Taxon_167 (SP133) -0.373514835895492 0.709518872806276 -0.526433968441421 0.598586719550985 1 FALSE PrevotellaPrevotella saccharolytica (SP137) -0.288190275838572 0.737303726992236 -0.390870499209625 0.695892960948926 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.0578796842848961 0.714112315719316 0.0810512338337067 0.935401207788579 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 1.00718155013866 1.27916123282586 0.787376543544589 0.43106147374643 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.106193354455726 0.914256722766375 -0.11615266457588 0.907531550938126 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) 0.972368398975917 0.776273057825997 1.25261129337542 0.210347202850836 1 FALSE ActinomycesActinomyces viscosus (SP147) -0.789261449898934 1.23196740793691 -0.640651241919344 0.521749299290884 1 FALSE StreptococcusStreptococcus cristatus (SP15) 1.66200675431809 0.926132047713777 1.7945678031776 0.0727225867744544 1 FALSE CardiobacteriumCardiobacterium valvarum (SP151) 0.418319239998186 0.816351502272868 0.512425393759318 0.608353322461842 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) 0.884719658858212 0.753374299759196 1.17434276579517 0.240257760149936 1 FALSE SelenomonasSelenomonas infelix (SP156) -0.434042798626634 0.692458577170071 -0.626814098253319 0.530781100991506 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.342803474801951 0.680423455730313 -0.503809020566484 0.614395588160933 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.354281484571348 0.772863887128096 -0.458400878177698 0.646664460872573 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.159047902472504 0.958829331246714 0.165877176771077 0.868253608947672 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 0.850803967243254 1.23069338141191 0.691320827830545 0.489363945809848 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.412595151544927 1.0370735534046 -0.397845601394832 0.69074400082121 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 1.15126635778931 1.22849269875275 0.937137321986652 0.348687925569499 1 FALSE ActinomycesActinomyces naeslundii (SP172) 0.56020897850897 0.888064900547583 0.630819862561332 0.528158314637716 1 FALSE PrevotellaPrevotella histicola (SP174) -0.497556668306768 0.873804927181026 -0.569413896431016 0.569075288420082 1 FALSE StreptococcusStreptococcus anginosus (SP175) 0.0539921769775702 1.15601314174824 0.0467055044858034 0.962747943190272 1 FALSE KingellaKingella oralis (SP176) 2.7908444222984 1.00144419299478 2.7868197167857 0.00532280824045286 0.702610687739777 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.324544425845328 1.16650041182305 -0.278220584027156 0.780843034645076 1 FALSE GemellaGemella haemolysans (SP183) -0.779944493881733 0.769039361026686 -1.01418020118045 0.310496774144948 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.210351554617126 0.970050661144312 0.216845947374528 0.828328402959316 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 0.0142763641773727 1.07488463058796 0.013281764173671 0.989402996987697 1 FALSE RothiaRothia dentocariosa (SP193) -0.606959966432734 1.02987993512383 -0.589350220091194 0.555626362595017 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.149496737519175 0.719742756532877 0.207708568321446 0.835456527035323 1 FALSE EikenellaEikenella corrodens (SP200) 0.65826839099555 0.65244536650589 1.00892492274234 0.313010641558621 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 2.03858030713005 1.05468735762034 1.93287640398917 0.0532514252839882 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.548957223481211 0.988391159604185 0.555404829501964 0.578617789975306 1 FALSE CampylobacterCampylobacter gracilis (SP205) 0.770690492496753 0.951298850962046 0.810145509707444 0.417856550743476 1 FALSE SelenomonasSelenomonas sputigena (SP21) -0.263952376059678 0.968328735681808 -0.272585503593288 0.785171856550466 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.155099956736569 0.976225293119897 -0.158877215976333 0.873765611688073 1 FALSE LancefieldellaLancefieldella rimae (SP217) -1.11575680115955 0.838188045982761 -1.33115332115164 0.183138567080118 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.795357060729014 0.835898329575616 0.951499760901323 0.341350739843688 1 FALSE LeptotrichiaLeptotrichia hofstadii (SP22) 0.496750682329661 0.767390494868067 0.647324518158209 0.517421936522236 1 FALSE PrevotellaPrevotella pleuritidis (SP233) 0.087806378220186 0.815156191149377 0.107717243852836 0.914219990487225 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 1.33546806355821 0.960231964928636 1.39077651269135 0.1642932075004 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) 1.17731096354987 0.960636176722096 1.2255534322756 0.220366771063953 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.444793628976848 0.880851317646667 0.504958805267141 0.613587769965549 1 FALSE LautropiaLautropia mirabilis (SP245) 0.331962400597533 1.04275036711466 0.318352705562777 0.750217408930114 1 FALSE ActinomycesActinomyces oris (SP249) 0.156190690478349 1.09604825613174 0.142503479755162 0.886682330975693 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.496272307887397 0.876934172684044 0.565917401038723 0.571449931889525 1 FALSE ActinomycesActinomyces johnsonii (SP26) 0.785389591222928 0.794457902175316 0.988585536215881 0.322865965682147 1 FALSE ArachniaArachnia propionica (SP260) -0.57860121667961 0.968609658803381 -0.59735230948906 0.55027218701237 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -1.53254101700009 0.983228703764981 -1.5586821368535 0.119071631737644 1 FALSE SelenomonasSelenomonas sp._HMT_919 (SP263) -0.322006599472455 0.738500836711996 -0.436027399652131 0.662816850151339 1 FALSE MogibacteriumMogibacterium neglectum (SP265) -1.83980228130419 0.640145608346242 -2.8740371835982 0 0 TRUE CapnocytophagaCapnocytophaga endodontalis (SP268) 2.66866807413643 0.857380654995931 3.11258256013381 0.00185458133083416 0.248513898331778 FALSE CapnocytophagaCapnocytophaga sp._HMT_338 (SP269) 0.287632886799162 0.631098218699377 0.455765645150989 0.648558511031873 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.906061063268232 0.784605083684905 1.15479886902199 0.248172800365629 1 FALSE SolobacteriumSolobacterium moorei (SP279) -1.12472633019821 0.726752399816971 -1.54760593908114 0.121717200634725 1 FALSE DialisterDialister invisus (SP28) -1.40208238544657 1.00868825558038 -1.39000566100558 0.164527158332084 1 FALSE ActinomycesActinomyces dentalis (SP286) 2.60746535418962 1.081601352043 2.41074527991709 0.015919962606502 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.34353473948658 0.800539930896761 -0.429128799486309 0.667829494780211 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.438959701007281 0.894576394716791 -0.490690011048469 0.623645712517936 1 FALSE Eubacterium_[XI][G-7]Eubacterium_[XI][G-7] yurii (SP292) -0.213112880749588 0.661962125940561 -0.321941199350012 0.747497240811262 1 FALSE ActinomycesActinomyces israelii (SP293) -0.331307863147937 0.901682617088006 -0.367432904737478 0.713296131017132 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.680701821469047 0.842904788620209 0.807566679723483 0.419340074629954 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.369254181311566 0.70429106872816 -0.524292011793337 0.600075452079718 1 FALSE ParvimonasParvimonas micra (SP31) -1.82758402567265 1.04642772859772 -1.74649808651547 0.0807244392804272 1 FALSE ActinomycesActinomyces massiliensis (SP310) -0.0884721198935816 0.914313324154029 -0.0967634590422716 0.922914243175705 1 FALSE RothiaRothia mucilaginosa (SP318) -0.226346597559473 1.0960468992268 -0.206511781310771 0.836391162926049 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.212809694805822 0.823168368009664 0.25852511232954 0.796001670637017 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.209724913423512 0.846379357462458 0.247790676337253 0.804296369213192 1 FALSE GemellaGemella morbillorum (SP332) 0.438652784050873 0.733016043447264 0.598421805323599 0.5495585197863 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) 0.212871506525743 0.889036115066094 0.239440786395857 0.810763806643551 1 FALSE PrevotellaPrevotella loescheii (SP36) -0.454246645974402 0.767472780638323 -0.591873298225113 0.553935435445916 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.108084385968623 1.69244365943935 0.0638629152384474 0.949079381326102 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.284858007200833 0.993617826847507 0.286687697728425 0.774351458160698 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.149348312476583 0.848289961903582 -0.176058092378509 0.86024830402188 1 FALSE PrevotellaPrevotella intermedia (SP41) 0.457918122506514 0.670923112365241 0.682519522829063 0.494910502312297 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -1.40178031261628 1.14063209862636 -1.22895043397815 0.219090390449785 1 FALSE TreponemaTreponema sp._HMT_951 (SP425) 0.395512921254996 0.578891369059235 0.683224767883049 0.494464824280481 1 FALSE NeisseriaNeisseria mucosa (SP44) -1.41993807308254 0.880885264158077 -1.61194440508626 0 0 TRUE CatonellaCatonella sp._HMT_451 (SP446) 0.413281331762071 0.599784250296847 0.689049990154841 0.490791809449625 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) -0.343609227385741 0.596935175190507 -0.575622348400027 0.564870471928222 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.568597360533872 1.25975419578148 0.451355798169139 0.651733135445765 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.335415895887815 1.38790327477441 0.241670944931183 0.809035144875171 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP50) 0.211833304069075 0.566565338934902 0.373890334462225 0.708485907781853 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.0467488657665941 1.08852988245118 -0.0429467913745499 0.965743949013374 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.659692943043573 1.18972626156053 -0.554491368609677 0.579242611151697 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.0528010700073614 0.683587675594951 -0.0772411087742428 0.938431739240023 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) 0.464385865868167 1.06579563793437 0.435717551601355 0.663041669740616 1 FALSE SelenomonasSelenomonas flueggei (SP57) 0.446618861773139 0.68137125158892 0.655470656755255 0.51216477277201 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.437040960928978 1.18369427518804 0.369217770238477 0.711965411457361 1 FALSE PrevotellaPrevotella denticola (SP60) -0.0609642875921418 1.06481958299244 -0.0572531615363561 0.954343530791057 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.345788204782794 1.12016452818584 -0.308694121338422 0.757554216073484 1 FALSE TreponemaTreponema socranskii (SP63) 0.461220540959491 0.895439248632514 0.515077423358259 0.606498918351747 1 FALSE StreptococcusStreptococcus gordonii (SP64) 0.230155827141363 1.20288557998117 0.191336425485262 0.8482620248184 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.450793748324631 0.721755621929664 -0.624579476249042 0.532247093325305 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.504859237668727 1.06765683840222 0.472866579887469 0.636308369530273 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) -0.2915089399452 1.13317514990176 -0.257249675807373 0.796986038231969 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) -0.762580429129266 0.828199197363785 -0.920769340946733 0.357170865013522 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.0524118304580024 0.809515901265716 0.0647446583520521 0.948377305167791 1 FALSE PrevotellaPrevotella melaninogenica (SP79) 0.22606495655235 0.765309372939333 0.295390288615046 0.767695751070722 1 FALSE SelenomonasSelenomonas noxia (SP8) 1.50469326161433 1.01719596310949 1.47925602950153 0.139071899853622 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.615616599700349 1.10953260963319 -0.554843178429761 0.579001930370204 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.861195961310671 1.22655084194187 -0.702128221564164 0.482599203858052 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.906830016793258 0.784250995793715 -1.15630075276536 0.247558160553897 1 FALSE VeillonellaVeillonella parvula (SP88) 0.238490103278891 0.436940378594629 0.545818411303547 0.585190766163392 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.834764612880647 0.848580416538245 0.983718922345676 0.32525373335639 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) 0.361319494190675 0.661450948430856 0.546252893049476 0.584892112344207 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.727573513127796 1.03093025131507 -0.705744653626847 0.480346946372543 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.657993384265375 0.804482899157127 -0.817908478793978 0.413409448504458 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.0838094805980471 0.738980284409387 -0.113412336385983 0.909703659792519 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -0.660911479422949 0.878644541732703 -0.752194372162853 0.451934177563431 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -1.39807672680228 0.89704333110124 -1.55853867737465 0.119105606843167 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -1.15049206285837 0.701059990973225 -1.64107505444896 0 0 TRUE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.0728790478539591 1.02787760376082 -0.0709024572452087 0.943475387700914 1 FALSE ActinomycesActinomyces israelii_nov_96.679% (SPN522) -0.538107737997143 0.708416235322784 -0.759592611188475 0.447498137118664 1 FALSE AlloprevotellaAlloprevotella rava_nov_97.244% (SPN61) -0.000469164005357819 0.693941533684798 -0.000676085783288658 0.999460561632831 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -0.524832412529748 0.915934081939247 -0.573002383990947 0.566643079810527 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.479419873557015 1.08499972401026 0.441861747010437 0.658589253165894 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 2.12641108621621 1.02182645886189 2.08099043411403 0.0374347816463584 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -1.36127645670386 0.997411635999959 -1.36480907939189 0.172313064394798 1 FALSE