Comp7DUS 12 Weeks P1...1 Comp7DUS 12 Weeks P1...2 Comp7DUS 12 Weeks P1...3 Comp7DUS 12 Weeks P1...4 Comp7DUS 12 Weeks P1...5 Comp7DUS 12 Weeks P1...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance SlackiaSlackia exigua (SP1) -0.645195137263437 0.43450414145561 -1.48489985642485 0.137570354086632 1 FALSE StreptococcusStreptococcus mutans (SP100) -0.072207612996106 0.752588402918635 -0.0959456891922272 0.923563707208536 1 FALSE TannerellaTannerella forsythia (SP101) 0.0487013464322536 0.386430892260868 0.126028605392596 0.899709281273316 1 FALSE PrevotellaPrevotella oralis (SP104) 0.42527896488397 0.431123487408473 0.986443507034063 0.323915524364152 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.45328324937473 0.574053844878214 0.789618000853029 0.429750892376653 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 0.967605431814858 0.609208310547932 1.58829979017289 0.112218564935134 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -0.908513383500082 0.499281751232942 -1.81964067634471 0.0688137429460085 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171 (SP109) -0.24983388925511 0.530668439114824 -0.47079093241694 0.637790040462579 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.126403176061804 0.623590427261424 -0.202702239379972 0.839367772742469 1 FALSE PrevotellaPrevotella salivae (SP111) -0.0894967135023213 0.445028905355428 -0.201103147290722 0.840617921087547 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) -0.033123687413565 0.41366169723523 -0.0800743400584394 0.93617813086696 1 FALSE VeillonellaVeillonella atypica (SP116) -0.390850304163209 0.456770023085067 -0.855682913522587 0.392173193794179 1 FALSE CatonellaCatonella morbi (SP118) -0.359062102344394 0.49525521173352 -0.725004187411951 0.46844946152614 1 FALSE PrevotellaPrevotella oris (SP12) -0.504216036257831 0.617549781810601 -0.816478365160319 0.414226592443057 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.023141993107413 0.480893598452018 0.0481228970023855 0.961618298174179 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.0220412846725192 0.527006980354764 0.0418235156158306 0.966639388661176 1 FALSE CampylobacterCampylobacter showae (SP122) 0.171082496364385 0.397190670412065 0.4307314071272 0.666663679455918 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 0.0659367405002081 0.423412437240916 0.155726980836633 0.876248228988087 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.15469845372238 0.508569188908847 -0.304183692398455 0.760987948137933 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) 0.204792246853538 0.431882054015786 0.474185590601207 0.635367567825 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 0.0295335025330082 0.577997216755898 0.0510962711875496 0.959248807274746 1 FALSE PrevotellaPrevotella veroralis (SP129) 0.250163542896942 0.414154507852963 0.604034335383252 0.54582081465484 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) -0.259477642307706 0.553010173692203 -0.469209527512467 0.638919876011366 1 FALSE PrevotellaPrevotella saccharolytica (SP137) -0.368383441611212 0.326699092099024 -1.12759248654279 0.259492061261956 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -0.0459767913613918 0.446170747115426 -0.103047525322178 0.917925251938549 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.110075489581426 0.724243071651418 0.151986941801779 0.879197234929489 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.1720322606732 0.548491507472427 0.313646170140288 0.753789788973391 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_71 (SP144) -0.104504407347001 0.419721539731177 -0.248985094770057 0.803372311065995 1 FALSE ActinomycesActinomyces viscosus (SP147) 0.806117739465834 0.717799386098342 1.12304044149098 0.261420319058469 1 FALSE StreptococcusStreptococcus cristatus (SP15) 0.654421293292903 0.598238638978073 1.0939134496742 0.273992939390005 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.230905113251521 0.507280244739348 -0.455182545833547 0.64897791636646 1 FALSE SelenomonasSelenomonas infelix (SP156) -0.175751584702256 0.37568641331008 -0.467814588112868 0.639917187415231 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.320616963645694 0.415943216762023 0.770819070308656 0.44081418200569 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP160) -0.068774547610069 0.57407050229814 -0.11980157025095 0.904640338023324 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP165) -0.261384180625578 0.386506871353077 -0.676273049714558 0.49886730033435 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.511452864914798 0.585895575191896 0.872942016582535 0.382694683073778 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 1.09537048775485 0.712783122553039 1.53675143686269 0.124354189818885 1 FALSE ActinomycesActinomyces odontolyticus (SP170) 0.206032480494764 0.55839986782759 0.36896942919474 0.712150511524129 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -0.119066655008485 0.647911068119457 -0.183770058681158 0.854193845780832 1 FALSE ActinomycesActinomyces naeslundii (SP172) -0.706539569655792 0.55746786857369 -1.26740859785069 0.20500922708544 1 FALSE PrevotellaPrevotella histicola (SP174) -0.12496274046845 0.390788548464108 -0.319770732688007 0.749142135547197 1 FALSE StreptococcusStreptococcus anginosus (SP175) 0.386273187024375 0.652429232768579 0.59205377016175 0.55381458261601 1 FALSE KingellaKingella oralis (SP176) 0.976137888335038 0.453992745183244 2.15011781287615 0.0315458969540414 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) -0.433817024066504 0.506363250884605 -0.856730861310798 0.391593643434273 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_178 (SP181) 0.354519785253852 0.45792087498092 0.774194417908168 0.438815828823315 1 FALSE GemellaGemella haemolysans (SP183) 0.499603440871148 0.541536988704756 0.922565681184762 0.356233587135494 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.127079876284445 0.390568775143171 0.325371315814638 0.744900062119678 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -1.48261333035582 0.594715336687995 -2.49297981554096 0.0126676047161146 1 FALSE LeptotrichiaLeptotrichia sp._HMT_221 (SP191) -0.657471338689414 0.394938324700617 -1.66474433492321 0.0959637737606017 1 FALSE RothiaRothia dentocariosa (SP193) 0.155046158324231 0.82799798140681 0.187254270911143 0.851461275256902 1 FALSE TannerellaTannerella sp._HMT_808 (SP196) -0.212420234391593 0.420732224863301 -0.504882254884588 0.613641538336612 1 FALSE StreptococcusStreptococcus vestibularis (SP198) 0.471790544305894 0.518627663339937 0.909690280050983 0.362985871695203 1 FALSE EikenellaEikenella corrodens (SP200) 0.369595240546833 0.325697382944549 1.13478111861205 0.256467039283105 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) 0.410503008910835 0.679893993773522 0.603775018856214 0.545993230220756 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP202) 0.0215129240319074 0.537191954632325 0.0400469959506963 0.968055658971967 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.781130559737695 0.578937270770676 -1.34924904506124 0.177256986298371 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.00617309838800754 0.602357466616158 0.0102482308764029 0.991823237937516 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -0.16500806692493 0.686922275112958 -0.240213591701908 0.810164677464638 1 FALSE LancefieldellaLancefieldella rimae (SP217) -0.0123111854333101 0.615031888268845 -0.0200171497903352 0.98402969175205 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.168083685130276 0.410219887397345 0.409740459431865 0.681996347114794 1 FALSE TreponemaTreponema maltophilum (SP227) 0.389780249511646 0.360973241225439 1.07980372226044 0.280229593292443 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -0.121916559919443 0.492197457230591 -0.247698475740653 0.804367711309255 1 FALSE FilifactorFilifactor alocis (SP234) 0.0238808587989974 0.408735568083782 0.0584261822648681 0.953409159958663 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.418142919998719 0.671580903041373 0.622624791897871 0.533531115483725 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.424565885095022 0.395773110461616 1.07275070961699 0.283382981523583 1 FALSE LautropiaLautropia mirabilis (SP245) 0.333803405151472 0.445768459448478 0.748826881032514 0.453961555570544 1 FALSE ActinomycesActinomyces oris (SP249) -0.0942221191486729 0.579498843030426 -0.162592419781114 0.870839355709532 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_132 (SP250) 0.32016972780527 0.346470083298494 0.924090544145004 0.355439176060379 1 FALSE SelenomonasSelenomonas dianae (SP252) -0.305006237188812 0.34599549643783 -0.881532390822943 0.378029730419978 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -0.172072158764436 0.390102586396177 -0.441094637064735 0.6591444858446 1 FALSE ArachniaArachnia propionica (SP260) 0.040821422953824 0.56754908674577 0.0719258014983112 0.942660956596877 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.944740971217928 0.525972664414328 -1.79617884186034 0.0724660785832263 1 FALSE Bacteroidetes_[G-5]Bacteroidetes_[G-5] bacterium_HMT_511 (SP264) 0.422095944262878 0.439811415031401 0.959720302468142 0.337196002434617 1 FALSE MogibacteriumMogibacterium neglectum (SP265) 0.205025987985977 0.420921411644106 0.487088521311263 0.626195600563594 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) 0.0131472826858542 0.371201006603385 0.0354182301555598 0.971746248269361 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) 0.41931904296842 0.621717784314475 0.674452385869537 0.500023747314492 1 FALSE ActinomycesActinomyces sp._HMT_414 (SP272) -0.600385014964554 0.574517856871699 -1.04502411506181 0.296011824197328 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) 0.0776919080143741 0.392540875525002 0.197920555179038 0.843107221586613 1 FALSE SolobacteriumSolobacterium moorei (SP279) -0.327885175740887 0.476462137224697 -0.688166278333798 0.491348076821965 1 FALSE DialisterDialister invisus (SP28) 0.0872561965374419 0.616582111159038 0.141515939172188 0.887462369119935 1 FALSE ColibacterColibacter massiliensis (SP283) 0.310524461417127 0.429000447715957 0.723832487985482 0.469168581446387 1 FALSE ActinomycesActinomyces dentalis (SP286) -0.478785080721411 0.668661945167647 -0.716034588451672 0.473969991731126 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP287) -0.140117162602269 0.456171202759272 -0.307159158129083 0.758722230882944 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.674793536963113 0.581726043398166 -1.15998509026911 0.246054876544415 1 FALSE ActinomycesActinomyces israelii (SP293) -0.48077962065844 0.531488665981908 -0.904590542434646 0.365682347554696 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP294) -0.51644856253801 0.439606696671536 -1.17479685011234 0.240076000640753 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) 0.149883974951286 0.45868839345964 0.32676644338173 0.743844541657041 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP301) 0.214600024300235 0.335302443276902 0.640019267986701 0.522160072872196 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.360283433823999 0.530232875774262 -0.679481507626064 0.496832820791322 1 FALSE ParvimonasParvimonas micra (SP31) 0.211234656115872 0.642848939435963 0.328591435961938 0.742464522058216 1 FALSE TreponemaTreponema denticola (SP311) 0.591159326747528 0.393546035637418 1.50213513341594 0.133062212985459 1 FALSE RothiaRothia mucilaginosa (SP318) 0.0667166448575176 0.594817172865276 0.112163279577385 0.910693944050034 1 FALSE MogibacteriumMogibacterium timidum (SP324) 0.397825713177669 0.372499820418897 1.06798900662634 0.285525470751808 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.0169299207876102 0.348654485798812 0.0485578745640446 0.961271641565228 1 FALSE GemellaGemella morbillorum (SP332) 0.378174982032705 0.493775905173095 0.765883831249592 0.443745427361797 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) 0.037228932341133 0.463538249460138 0.0803146933063061 0.935986972396555 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.0918491455513061 0.50711847756801 -0.181119698086702 0.856273623457348 1 FALSE PrevotellaPrevotella loescheii (SP36) 0.0758632094996245 0.446071614655793 0.170069574048471 0.864955421295976 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.698066816311807 0.837279995792473 -0.833731630780331 0.404432229637542 1 FALSE TreponemaTreponema sp._HMT_257 (SP367) -0.155066861789761 0.343347963176873 -0.451631809185598 0.651534250579249 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.549975689573891 0.497186830111841 1.10617509609049 0.268650739804704 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.416679094267046 0.44741067644273 0.931312362905543 0.351692008721947 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -0.240709450731459 0.485580845272601 -0.495714468712881 0.620095877433674 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -0.761603272352326 0.670285908495229 -1.13623643686931 0.25585762489904 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP442) 0.448571936667661 0.600094588232195 0.747502052949851 0.454760564052475 1 FALSE GemellaGemella moribillum (SP45) -0.468276017148023 0.380518165921852 -1.23062723172116 0.218462315460646 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) -0.203596691271337 0.371573740241767 -0.547930785256422 0.583739429432538 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.426398423675392 0.626221645249222 -0.680906555866007 0.495930619563225 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) 0.572801170331836 0.806989622463698 0.709799921073462 0.477828218050129 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP50) -0.456651363597726 0.3890788359746 -1.17367310009002 0.240525988851714 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.496829741358117 0.658439727483939 -0.754556143288357 0.450515346664557 1 FALSE StreptococcusStreptococcus mitis (SP52) 1.10284979269218 0.758166961947678 1.454626550673 0.145772676511426 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.0685741060661527 0.433297036535266 0.158261193324759 0.874250985951494 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.0419160679044141 0.466306497174035 0.0898895215023567 0.928375008071667 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.0586976385348671 0.720420876470742 -0.0814768706071095 0.935062718294651 1 FALSE SelenomonasSelenomonas flueggei (SP57) 0.300607561494206 0.356466433096013 0.843298368610315 0.399061594989355 1 FALSE StreptococcusStreptococcus oralis (SP58) 0.198495074290415 0.677132644431778 0.293140606825984 0.769414679614421 1 FALSE PrevotellaPrevotella denticola (SP60) 0.0069506458036274 0.637925611347355 0.0108956995611871 0.991306661548107 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.81209400477939 0.573231207773202 1.41669538184092 0.156572007844911 1 FALSE TreponemaTreponema socranskii (SP63) 0.167254959066372 0.537813582755235 0.310990581921565 0.755807781421455 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.0709745994167596 0.731556566647838 -0.0970186075179145 0.922711617494564 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) 0.346370782626553 0.45671352180727 0.758398352770293 0.448212543707564 1 FALSE CampylobacterCampylobacter concisus (SP67) -0.270716627214668 0.485878214141076 -0.55716971729888 0.577411477808404 1 FALSE ActinomycesActinomyces sp._HMT_170 (SP69) 0.346076379402512 0.496924391245817 0.696436692380665 0.486155390993921 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) 0.251291137854721 0.431475744583575 0.582399221762158 0.560297805628112 1 FALSE ParvimonasParvimonas sp._Oral_Taxon_110 (SP72) -0.0793244965860632 0.449467733909296 -0.17648540840992 0.859912611161848 1 FALSE ActinomycesActinomyces sp._HMT_525 (SP73) -0.0559267630829494 0.590945840075355 -0.0946394056616387 0.924601249098168 1 FALSE PrevotellaPrevotella melaninogenica (SP79) -0.428595392434112 0.492623005591853 -0.870027155794693 0.384285564043367 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.0594813354759341 0.522784731882727 0.113777874234623 0.909413878479705 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.995651802832865 0.548451121772422 -1.8153883970831 0.0694642429162201 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -0.341847784948098 0.648667677792193 -0.526999874745743 0.598193675456847 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.169238552285213 0.525168945021309 -0.322255445394522 0.747259183549745 1 FALSE VeillonellaVeillonella parvula (SP88) 0.11794187745547 0.538870352661104 0.218868744352026 0.82675229456153 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.101613310887102 0.546127763800919 0.186061426688688 0.852396590706026 1 FALSE MegasphaeraMegasphaera micronuciformis (SP92) -0.0269439894919275 0.417491535193371 -0.0645378102802678 0.948542001599582 1 FALSE StreptococcusStreptococcus intermedius (SP94) -0.459774998285912 0.699020752048875 -0.657741557655165 0.510704213595394 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -0.375796687190638 0.562107095680474 -0.668549979316143 0.503782589908762 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.150828214609928 0.389052935087083 -0.387680443989371 0.698252529578537 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.805311123416333 0.479620939707483 1.67905747381982 0.0931408431360419 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.319866443077088 0.606534625909472 -0.527367159949792 0.597938644208085 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_171_nov_97.974% (SPN109) -0.53716303246428 0.492549599423251 -1.0905765289288 0.275459261981175 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) -0.0301643956580446 0.310479457604802 -0.0971542397385908 0.922603907463081 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -0.0138711747232348 0.567999787609756 -0.0244210913909092 0.980516724844604 1 FALSE ActinomycesActinomyces sp._str._ChDCB197_nov_96.023% (SPN246) 0.280894501701777 0.390660721153671 0.719024172361785 0.472126026116061 1 FALSE ActinomycesActinomyces israelii_nov_97.037% (SPN353) -0.252304434591054 0.485335215842297 -0.519856021890315 0.603163929436687 1 FALSE PrevotellaPrevotella veroralis_nov_97.348% (SPN464) 0.215300582094737 0.3684067773671 0.584409938474614 0.558944541812221 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP1) 0.241814326236469 0.500655745367138 0.482995208731985 0.629099138210782 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.213093555033199 0.645349616223769 0.330198623623742 0.741249886759288 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) 0.0508785309907036 0.514397524679553 0.0989089732156054 0.921210544249496 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) -0.326569081279529 0.371397228933322 -0.879298648020226 0.379239368760269 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) -0.0996503140351463 0.56383732121887 -0.176735931242948 0.859715816069577 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -1.07324126304274 0.646069074099153 -1.66118656049156 0.0966759838996882 1 FALSE