Comp5OSS 12 Weeks P2...1 Comp5OSS 12 Weeks P2...2 Comp5OSS 12 Weeks P2...3 Comp5OSS 12 Weeks P2...4 Comp5OSS 12 Weeks P2...5 Comp5OSS 12 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance SelenomonasSelenomonas sputigena (SP1) 0.134945989160181 0.876479204177256 0.15396370902702 0.877638350339498 1 FALSE LigilactobacillusLigilactobacillus salivarius (SP100) -0.221472318788768 1.25165578238035 -0.176943471125569 0.859552792297317 1 FALSE CatonellaCatonella morbi (SP103) -1.48893083714296 0.663096210543782 -2.24542202695131 0.0247410526681295 1 FALSE StomatobaculumStomatobaculum longum (SP106) 0.173084775623338 0.839050883526584 0.206286387418903 0.836567211132263 1 FALSE OribacteriumOribacterium sp._HMT_078 (SP107) -0.665862737765229 0.917320803238689 -0.725877725016523 0.467913733016482 1 FALSE OlsenellaOlsenella sp._HMT_807 (SP108) -0.757778264437573 0.732935476925517 -1.03389491748478 0.301185291318765 1 FALSE EikenellaEikenella corrodens (SP109) 0.948677094188212 0.559810749699119 1.69463893770903 0 0 TRUE GemellaGemella sanguinis (SP11) -0.495221416701669 0.783505461386671 -0.632058665966682 0.527348543198788 1 FALSE PrevotellaPrevotella veroralis (SP111) -0.503442532969342 0.828509355545241 -0.607648579463568 0.543420573785809 1 FALSE StreptococcusStreptococcus mitis (SP12) -0.192412645074913 1.23872986527913 -0.155330593431326 0.876560698239363 1 FALSE StreptococcusStreptococcus parasanguinis_clade_411 (SP120) -1.39686350023325 1.27091395571926 -1.09910155124759 0.271723773374871 1 FALSE StreptococcusStreptococcus sanguinis (SP123) 1.11544340957942 1.28689791513273 0.8667691480908 0.386068509483263 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) -0.76067872080349 0.884569408271988 -0.859942378393439 0.389820806423013 1 FALSE ActinomycesActinomyces israelii (SP126) 0.896678355047047 0.844854552297295 1.06134050246736 0.288535185373899 1 FALSE StreptococcusStreptococcus mutans (SP128) 0.162385771703718 1.50173313154542 0.108132242868351 0.913890791986951 1 FALSE SchaaliaSchaalia odontolytica (SP13) -0.256155998029119 0.807434733398461 -0.317246691817391 0.751056423344966 1 FALSE StreptococcusStreptococcus oralis (SP131) -1.05675235038048 1.1507497966007 -0.918316347743106 0.358453271117329 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP132) -1.25658759306559 0.581196619971885 -2.16206968499985 0 0 TRUE StreptococcusStreptococcus intermedius (SP136) 0.83316150459158 1.21233149474411 0.687239016889055 0.491932121055126 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP138) -2.33353645777163 0.90780111986616 -2.57053709970712 0.0101540950093485 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP139) 0.567434495050084 0.66260989064967 0.856362850988733 0.391797106272349 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP140) -0.717071198004668 0.634210293516684 -1.13065209652862 0.258201551077269 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP142) 0.272379315406585 0.636989825833517 0.427603871145304 0.668939547077709 1 FALSE LautropiaLautropia mirabilis (SP145) 0.0315622049807095 0.868699680123388 0.0363327001297232 0.971017076212148 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP146) 1.19846307222458 0.74462277874217 1.60949020959182 0 0 TRUE RothiaRothia dentocariosa (SP147) 0.956202948531092 1.34378200568881 0.711575943481213 0.476727408157155 1 FALSE GemellaGemella morbillorum (SP15) 0.265403282895348 0.668101643710446 0.397249857703349 0.691183219343892 1 FALSE PrevotellaPrevotella pleuritidis (SP150) 0.473072023094858 0.796232903398389 0.594137746726802 0.552419986125438 1 FALSE PrevotellaPrevotella oulorum (SP151) 0.241212103899617 0.738212098935274 0.32675176178705 0.743855646902255 1 FALSE TannerellaTannerella forsythia (SP153) -0.423111419361292 0.653993902382046 -0.646965388851778 0.517654344152637 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP155) 0.190426812513936 0.607462659684693 0.313479041843952 0.753916741048179 1 FALSE MycoplasmaMycoplasma salivarium (SP160) 0.117529348565063 0.456372189761037 0.257529602376961 0.796769966326396 1 FALSE StreptococcusStreptococcus anginosus (SP162) -0.87723128016667 1.06424495667351 -0.824275722112527 0.409782910069414 1 FALSE ParvimonasParvimonas micra (SP166) -0.433384690760191 1.11574840297303 -0.38842510516295 0.697701468604253 1 FALSE LeptotrichiaLeptotrichia hongkongensis (SP171) 0.633782608571504 1.09812150022514 0.577151625245079 0.563837032410767 1 FALSE HaemophilusHaemophilus haemolyticus (SP174) -0.120218957162965 0.714557520234165 -0.168242518983733 0.866392492339398 1 FALSE StreptococcusStreptococcus vestibularis (SP175) -0.200203648131603 0.823698056113396 -0.243054656552499 0.807963056843841 1 FALSE PorphyromonasPorphyromonas gingivalis (SP176) -0.114887113829611 0.671631492384806 -0.171056770166738 0.864179127205336 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP177) -0.141538164814308 0.960675802008859 -0.147331872540496 0.882870076326456 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP18) -0.412408189270394 0.778892293823829 -0.52948038199961 0.596472249963089 1 FALSE PorphyromonasPorphyromonas endodontalis (SP180) -0.245504464870711 0.85809548212973 -0.286103901003402 0.774798543819202 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP181) 0.450678056484312 0.66390732365292 0.678826758537038 0.497247637004176 1 FALSE ArachniaArachnia propionica (SP182) 0.911835501889879 0.653331864261474 1.39566972279948 0.162813975831652 1 FALSE CampylobacterCampylobacter gracilis (SP185) -0.247136312936553 1.00556072776344 -0.24576965479373 0.805860548643293 1 FALSE StreptococcusStreptococcus salivarius (SP188) -0.424502819548357 1.37893535520898 -0.307848238095269 0.758197814132878 1 FALSE GemellaGemella haemolysans (SP190) 1.31769914511967 0.926102808485433 1.42284326647779 0.154781595701165 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP192) -0.0904448854386866 0.572009774741904 -0.158117727060689 0.874364032154107 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP195) -0.0116928272400982 0.66794614470058 -0.0175056437302138 0.986033230491468 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP198) 0.242692018484531 0.613163648876503 0.395803011038267 0.69225035536254 1 FALSE FusobacteriumFusobacterium nucleatum (SP20) -0.888360767712032 1.04475825044344 -0.85030270623369 0.395156812381534 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP201) -0.526995012494873 0.591473013122015 -0.890987417520873 0.372935920480909 1 FALSE PrevotellaPrevotella denticola (SP21) 0.310348793185708 1.09702360094279 0.282900744267482 0.777252924036807 1 FALSE TannerellaTannerella sp._HMT_808 (SP212) -1.20397443363261 0.571073858098342 -2.10826396018513 0 0 TRUE LancefieldellaLancefieldella rimae (SP227) -1.18431946820172 1.09709225263184 -1.07950763972732 0.280361489947115 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP228) -0.655207840797467 0.976028228655125 -0.671300093133865 0.502029375346453 1 FALSE PrevotellaPrevotella melaninogenica (SP229) 0.338653890413701 0.83584331827932 0.405164320881166 0.685356729342846 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP230) -0.143215878912109 1.49931235109914 -0.0955210425680263 0.923900977126011 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP231) -0.223960745377735 0.724321276731332 -0.309200837490802 0.757168756871977 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP234) 0.658093740511427 0.784424533126862 0.838950992376722 0.401496811214385 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP238) 0.185988344894924 0.705095863696692 0.263777387545319 0.791951459769567 1 FALSE CorynebacteriumCorynebacterium durum (SP241) 0.564433992689375 0.960384177979053 0.587716880006415 0.556722343487941 1 FALSE StreptococcusStreptococcus sobrinus (SP242) 0.0361986839380664 0.903139454100028 0.0400809462743914 0.968028592264258 1 FALSE MogibacteriumMogibacterium neglectum (SP263) -0.447765584489846 0.713210209126953 -0.627817127068273 0.530123745010803 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP266) -0.344001006144517 1.04714480731865 -0.328513309468036 0.742523582688379 1 FALSE HaemophilusHaemophilus sp._HMT_036 (SP274) 0.233196521543128 0.715368533770535 0.325980960210823 0.74443876055143 1 FALSE ScardoviaScardovia wiggsiae (SP277) -1.36374402248699 1.22027536242914 -1.11757072581737 0.263750377386619 1 FALSE NeisseriaNeisseria subflava (SP278) 0.250052721497589 0.617261828475122 0.405099926744728 0.685404060330363 1 FALSE AlloprevotellaAlloprevotella rava (SP28) -1.2997544137197 0.577882611877142 -2.24916684981694 0 0 TRUE KingellaKingella oralis (SP299) 0.84646029934136 1.09036483667614 0.776309241521128 0.437566417768474 1 FALSE PrevotellaPrevotella oralis (SP300) -0.170266725461232 0.739770576206682 -0.230161527015995 0.817966256322006 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP31) 1.37920014471867 1.13899216284151 1.21089520166486 0.2259355718492 1 FALSE RothiaRothia aeria (SP311) 1.37667356038876 0.747175281023048 1.84250415579031 0.0654014391995739 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP32) -0.0599999721591832 0.675830548366724 -0.088779609480786 0.929257062968572 1 FALSE TreponemaTreponema lecithinolyticum (SP320) -0.431851388596332 0.644227302609116 -0.670340090907877 0.502641015687358 1 FALSE PrevotellaPrevotella salivae (SP331) 0.939073240712609 0.666411256042959 1.4091497287856 0 0 TRUE LachnoanaerobaculumLachnoanaerobaculum saburreum (SP34) 0.0635715374877562 0.876117025895472 0.0725605548217491 0.942155816632199 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_335 (SP341) -0.381562590678462 0.68899447048042 -0.553796303201689 0.579718258583987 1 FALSE LancefieldellaLancefieldella parvula (SP353) 0.380528512154268 1.22942059898048 0.309518575229527 0.756927084433052 1 FALSE GemellaGemella bergeri (SP354) -0.0488526155620801 0.580949108772974 -0.0840910414085357 0.932984047336707 1 FALSE TannerellaTannerella sp._HMT_286 (SP36) 0.266802331338522 0.543698559117328 0.490717377974413 0.623626353685123 1 FALSE SolobacteriumSolobacterium moorei (SP369) -1.52630819363352 0.624564940947218 -2.44379422149234 0 0 TRUE TreponemaTreponema sp._HMT_237 (SP4) -1.13235476631028 0.586005030509634 -1.93232942953664 0 0 TRUE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP40) -0.772167780518948 0.834857317297173 -0.924909879233998 0.355012787319758 1 FALSE GranulicatellaGranulicatella adiacens (SP42) -0.119453130147202 1.14468744572591 -0.104354363798802 0.916888137293454 1 FALSE StreptococcusStreptococcus constellatus (SP45) 0.0824583327686225 0.582321206375916 0.141602833394653 0.887393728762516 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP47) 0.553332163054527 0.86529180093047 0.639474640184404 0.522514206098286 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP5) -1.08329022643057 0.842045450954573 -1.28649852000568 0.198269135005374 1 FALSE VeillonellaVeillonella parvula (SP50) 0.377349202120733 1.06870350232598 0.353090638609729 0.72402049078763 1 FALSE StreptococcusStreptococcus cristatus (SP51) 1.8055925816836 1.06869242229439 1.68953437304922 0.0911170704629642 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP52) -0.726429122916412 0.80158230627354 -0.906243959267881 0.364806740290813 1 FALSE StreptococcusStreptococcus gordonii (SP53) -1.84099850630667 1.24376018793681 -1.48018767939547 0.13882316750805 1 FALSE CardiobacteriumCardiobacterium hominis (SP54) 0.549028108033331 0.70243234389943 0.781609948348189 0.434443838537237 1 FALSE PorphyromonasPorphyromonas pasteri (SP55) 0.960080400952927 0.893326158658531 1.07472549823755 0.282497644351079 1 FALSE DialisterDialister invisus (SP56) -1.11195971969939 0.96964210469275 -1.14677334484329 0.251475308335992 1 FALSE PeptococcusPeptococcus sp._HMT_167 (SP57) -0.851763822218001 0.695969761568908 -1.2238517666312 0.221008151843435 1 FALSE PrevotellaPrevotella maculosa (SP59) -0.461438326058996 0.68348190664717 -0.675128809660211 0.49959393129716 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP6) -0.694413324057932 0.89500444971876 -0.775876951534866 0.437821642644819 1 FALSE TreponemaTreponema socranskii (SP60) -1.12742002875857 0.839680983552592 -1.34267662462545 0.179376706932578 1 FALSE PrevotellaPrevotella oris (SP63) -0.995496588823945 1.10957271682548 -0.897189137519612 0.369618000500704 1 FALSE NeisseriaNeisseria sicca (SP67) 0.344842827399589 0.78346414441744 0.440151383897732 0.659827468193109 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP70) -1.26408664394267 0.649728937868637 -1.94556001782738 0 0 TRUE TreponemaTreponema sp._HMT_231 (SP74) -0.385320511731555 0.664145108920636 -0.580175185446709 0.561796485761229 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP75) -0.217403261434491 0.644397645657826 -0.337374388158352 0.735834689346374 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP77) 0.786417529139662 0.968627210966977 0.811888743404786 0.416855474114892 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP78) 0.295887980754493 0.604091480126696 0.489806578123625 0.624270775425355 1 FALSE AlloprevotellaAlloprevotella tannerae (SP79) -0.12101781763631 0.924073402331208 -0.130961260578447 0.895805952983938 1 FALSE HaemophilusHaemophilus parainfluenzae (SP81) 0.631614860225334 1.19105445065166 0.530298895973863 0.595904712034186 1 FALSE ActinomycesActinomyces oris (SP85) 0.124950452932099 1.07107245997019 0.116659196834896 0.907130125632343 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP88) -1.31087080438302 1.07999432350467 -1.21377564293962 0.224833409828135 1 FALSE ActinomycesActinomyces sp._HMT_169 (SP9) 0.832510575485633 1.24808959635054 0.667027894407523 0.504754315922806 1 FALSE SelenomonasSelenomonas noxia (SP90) 0.163868906892517 0.947633029785411 0.172924435664326 0.862710824110833 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP93) -1.14561216433662 0.938259127222116 -1.22099762325618 0.222086919684628 1 FALSE LeptotrichiaLeptotrichia wadei (SP99) -0.100609800442565 0.89969474578835 -0.111826595535363 0.910960899593182 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN133) 0.449707096390429 1.09839384943588 0.409422445893513 0.682229670197925 1 FALSE PorphyromonasPorphyromonas uenonis_nov_94.667% (SPN15) 0.0597538202964706 0.542319763802286 0.110181896889628 0.912265119041652 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN249) 0.162948307382341 0.674749190500018 0.241494631896615 0.809171776515103 1 FALSE FusobacteriumFusobacterium nucleatum_nov_97.018% (SPN283) -0.710350739137993 0.665948379524253 -1.06667537752019 0.286118449493285 1 FALSE CapnocytophagaCapnocytophaga gingivalis_nov_97.665% (SPN39) 0.329792746036968 0.651828820449422 0.505949929936487 0.612891799735852 1 FALSE StreptococcusStreptococcus infantis_infantis_clade_638 (SPP45) 0.6467225929417 0.766058728468252 0.844220643807341 0.398546120795213 1 FALSE VeillonellaVeillonella dispar_parvula (SPP5) 0.0887254706308425 1.023233749073 0.0867108524432697 0.930901349909341 1 FALSE