Comp11OSS 24 Weeks P2...1 Comp11OSS 24 Weeks P2...2 Comp11OSS 24 Weeks P2...3 Comp11OSS 24 Weeks P2...4 Comp11OSS 24 Weeks P2...5 Comp11OSS 24 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Selenomonas sputigena (SP1) 1.12579480579409 1.31519483670422 0.855990895322589 0.392002815549676 1 FALSE Catonella morbi (SP103) 0.309847379812782 0.895425248445782 0.346033775963537 0.729317331367993 1 FALSE Stomatobaculum longum (SP106) -0.625882742110225 0.875289648845824 -0.71505785877341 0.474573292196694 1 FALSE Oribacterium sp._HMT_078 (SP107) 0.147706896249603 1.18973695967408 0.124150884822529 0.901195809510554 1 FALSE Olsenella sp._HMT_807 (SP108) 1.69573032091857 1.37537638010419 1.23292092655402 0.217605267114563 1 FALSE Eikenella corrodens (SP109) 0.214912204083797 1.174226547631 0.183024480682524 0.854778810245 1 FALSE Gemella sanguinis (SP11) -1.4892348776926 1.16118793770048 -1.2825097723989 0.199663879061363 1 FALSE Prevotella veroralis (SP111) -2.02609319617834 1.07279341259847 -1.88861450152907 0 0 TRUE Colibacter massiliensis (SP113) -0.572526772559972 1.11083923191991 -0.515400209236806 0.606273386293517 1 FALSE Fusobacterium periodonticum (SP117) -0.328714962423815 1.11985358257062 -0.293533875802988 0.769114110095761 1 FALSE Streptococcus mitis (SP12) -0.998922481791728 1.42119727413304 -0.702873907776872 0.482134332997391 1 FALSE Streptococcus parasanguinis_clade_411 (SP120) -0.529555254342955 1.12962424538542 -0.46878885302455 0.63922056842725 1 FALSE Streptococcus sanguinis (SP123) -1.0722523537068 1.44754046920859 -0.740740847330525 0.458850587288534 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) -0.405134883894589 1.20952971364515 -0.334952402842289 0.73766099123931 1 FALSE Actinomyces israelii (SP126) -0.602994566741016 1.50111585172944 -0.40169755455337 0.68790662447277 1 FALSE Streptococcus mutans (SP128) -0.69176646706303 2.04368586713759 -0.338489627093193 0.734994242649204 1 FALSE Schaalia odontolytica (SP13) -2.02516662441498 0.955355415954497 -2.11980441058329 0 0 TRUE Streptococcus oralis (SP131) -0.51082152320283 1.69132176753099 -0.302025039238118 0.762632975196537 1 FALSE Campylobacter showae (SP134) 1.15906978568084 1.36583436408306 0.848616652326627 0.396094637839171 1 FALSE Streptococcus intermedius (SP136) 0.385828222838684 1.4908778939437 0.258792637818302 0.795795238590718 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP138) 0.150762055697057 1.13406665165906 0.13293932545896 0.894241365687326 1 FALSE Leptotrichia sp._HMT_215 (SP139) -2.03629429168369 1.10796664781878 -1.83786605462581 0.0660821452066128 1 FALSE Capnocytophaga sp._HMT_336 (SP142) -0.699545724154694 1.25983461241565 -0.555267903628527 0.578711429176914 1 FALSE Abiotrophia defectiva (SP144) 0.663542202523906 0.818051845456041 0.811124876998473 0 0 TRUE Peptidiphaga sp._HMT_183 (SP146) -1.4675491940261 1.30392134021748 -1.12548905272255 0.260381853579963 1 FALSE Rothia dentocariosa (SP147) 0.134016391064921 1.73912300898955 0.0770597538944562 0.938576009496967 1 FALSE Gemella morbillorum (SP15) -2.19792727267064 0.995339388817413 -2.20821892247432 0 0 TRUE Prevotella pleuritidis (SP150) -1.32790071620972 1.21994908142993 -1.08848863974983 0.276379448997092 1 FALSE Prevotella oulorum (SP151) 0.153670000121254 1.23213640555295 0.124718334292128 0.900746542066964 1 FALSE Tannerella forsythia (SP153) 0.67187589229456 1.22561806768503 0.548193527828464 0.583559025695821 1 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP155) -1.21806535063635 1.07089561537916 -1.1374267791778 0.255359917769343 1 FALSE Mycoplasma salivarium (SP160) -1.03381146794123 0.831100820879764 -1.24390620484153 0.213534085461451 1 FALSE Rothia mucilaginosa (SP161) -0.580805374192845 1.14190662791352 -0.508627728393244 0.611013189188681 1 FALSE Streptococcus anginosus (SP162) 0.315799337124739 1.40714473602659 0.224425625196506 0.822426133151991 1 FALSE Peptoanaerobacter [Eubacterium] yurii (SP164) 0.141336694112903 1.10397502396324 0.128025264199826 0.898128979617819 1 FALSE Parvimonas micra (SP166) -0.700622878576131 1.54372617036098 -0.453851785392937 0.649935508059631 1 FALSE Leptotrichia hongkongensis (SP171) 1.39618690939824 1.71141632566495 0.815807871212029 0.414610030667191 1 FALSE Schaalia meyeri (SP173) 1.07479137746598 1.1129422495397 0.965720708249234 0 0 TRUE Haemophilus haemolyticus (SP174) -2.01919566015119 0.95870959825075 -2.10615984635535 0 0 TRUE Porphyromonas gingivalis (SP176) -0.917682264390037 1.32973807758215 -0.690122573656499 0.490117108532518 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP177) 1.21020788281447 1.11652310014458 1.08390760805376 0.278405765990594 1 FALSE Bacteroidales_[G-2] bacterium_HMT_274 (SP18) -2.1759684472318 1.20718091102498 -1.80252058938229 0.0714635382997893 1 FALSE Porphyromonas endodontalis (SP180) -0.296792728079394 1.25836150392046 -0.235856490487614 0.813544031366421 1 FALSE Capnocytophaga sputigena (SP181) -1.15251964181377 0.944424484502254 -1.22034070561099 0.222335744902196 1 FALSE Arachnia propionica (SP182) -1.46426187480363 1.44123584190439 -1.01597658913951 0.309640534911305 1 FALSE Campylobacter gracilis (SP185) 0.923393462583112 1.05840355293601 0.872439874206412 0.382968455609228 1 FALSE Streptococcus salivarius (SP188) -1.92477880674357 1.15819723485514 -1.66187480751869 0.0965378788811414 1 FALSE Actinomyces massiliensis (SP19) -2.22839885169362 1.07620451336433 -2.07060909336592 0 0 TRUE Gemella haemolysans (SP190) -2.93963116292981 1.09946287248292 -2.67369752676707 0 0 TRUE Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP191) -0.455607534188227 0.972336936992954 -0.468569604685838 0.639377307676228 1 FALSE Capnocytophaga sp._HMT_380 (SP192) -1.1481987051944 1.09766310985069 -1.04603925821155 0.295542907416437 1 FALSE Selenomonas artemidis (SP197) -0.337904323833678 0.712088397333608 -0.474525810417569 0.635124996957273 1 FALSE Lachnoanaerobaculum orale (SP198) -1.9588041786074 0.875827189191416 -2.23651903341322 0 0 TRUE Treponema denticola (SP2) 0.851111296365133 0.890188072305344 0.95610278641567 0 0 TRUE Fusobacterium nucleatum (SP20) 0.303952043124147 1.19337829245136 0.254698820187008 0.798955727555398 1 FALSE Neisseria elongata (SP205) -0.783293010250367 0.985822115399682 -0.794558164210788 0.426870562286407 1 FALSE Prevotella denticola (SP21) -0.339275739815826 1.45124832692188 -0.233782002378211 0.815154222466521 1 FALSE Neisseria flavescens (SP210) -0.425220608055902 0.946599421114783 -0.449208607749973 0.653281178625749 1 FALSE Lancefieldella rimae (SP227) 0.0536284567693733 1.44112999064256 0.0372127824121279 0.970315346781214 1 FALSE Capnocytophaga endodontalis (SP228) -1.81591123937206 1.20954244109018 -1.50132081164126 0.133272604640723 1 FALSE Actinomyces sp._HMT_448 (SP230) 0.446636828146529 1.89064135669481 0.236235617381889 0.813249842861714 1 FALSE Aggregatibacter sp._HMT_458 (SP234) -1.34579139183253 1.17023335320348 -1.15001968466243 0.250135763794203 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_129 (SP237) -0.794049430439962 0.710311886668495 -1.1178884168252 0.263614652738389 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP238) 0.323224756919529 1.3371472054345 0.241727130420543 0.808991605837127 1 FALSE Selenomonas dianae (SP239) 0.093978957842991 0.847765715208788 0.110854869637947 0.911731433758311 1 FALSE Corynebacterium durum (SP241) -0.0828026165597653 1.53836599345186 -0.0538250435281456 0.957074556587371 1 FALSE Neisseria perflava (SP243) -0.785321432853743 1.0513430283172 -0.746969744128844 0.455081824356231 1 FALSE Actinomyces naeslundii (SP244) 1.33317628337387 1.19473957241785 1.11587187212344 0 0 TRUE Leptotrichia sp._HMT_221 (SP25) -0.477480064248924 1.12396663971264 -0.424816936177929 0.670970130480649 1 FALSE Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP250) 0.775057375474858 0.758285683243467 1.02211790701316 0 0 TRUE Bergeyella sp._HMT_900 (SP26) 0.628673013170628 1.11180443867774 0.565452872196036 0.571765770846774 1 FALSE Mogibacterium neglectum (SP263) -1.70897996026733 0.888919520476183 -1.92253620367326 0.0545383226672117 1 FALSE Schaalia sp._HMT_180 (SP266) 1.5742060139246 0.881012749556398 1.78681411218764 0 0 TRUE Haemophilus sp._HMT_036 (SP274) 0.649066028508361 0.780344537315383 0.8317685297591 0 0 TRUE Prevotella sp._HMT_292 (SP276) 0.788687430070203 0.817436239277261 0.964830517873204 0 0 TRUE Scardovia wiggsiae (SP277) 0.413231950674641 1.13427794818043 0.364312778307586 0.715624458872604 1 FALSE Neisseria subflava (SP278) -1.50420239078128 0.736642882146096 -2.04196962631203 0 0 TRUE Selenomonas sp._HMT_134 (SP280) 0.604177206211097 0.715255110543568 0.844701697764794 0 0 TRUE Prevotella vespertina (SP289) -0.920289685650853 0.877511857790473 -1.04874900262669 0.294293654427892 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_150 (SP294) 1.03199478703678 0.905629671534923 1.13953287913776 0 0 TRUE Kingella oralis (SP299) 0.0415692951376205 1.42954424561773 0.0290787048145248 0.976801819711446 1 FALSE Capnocytophaga granulosa (SP3) 0.535421983291045 1.60478259188443 0.333641445264135 0.73865013975896 1 FALSE Prevotella oralis (SP300) -0.615601833417698 1.24705063149734 -0.493646222430073 0.621556050887144 1 FALSE Corynebacterium matruchotii (SP31) 0.128966588408536 1.102503408533 0.116976135774619 0.906878964524837 1 FALSE Rothia aeria (SP311) -1.47514146103536 1.1042250768556 -1.33590650307995 0.181579835126945 1 FALSE Capnocytophaga leadbetteri (SP32) 1.2886159383804 1.16960836668929 1.10174993192634 0.270570402683515 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_348 (SP323) -0.475568400331624 1.16975344192703 -0.406554392819894 0.684335299786794 1 FALSE Fretibacterium fastidiosum (SP33) 0.928062100770306 0.83654843327978 1.10939434448731 0 0 TRUE Selenomonas flueggei (SP330) 0.587847138151063 0.746995599658537 0.786948595707628 0 0 TRUE Prevotella salivae (SP331) -0.094757160578629 1.08729202052375 -0.0871496882070229 0.930552530117858 1 FALSE Alloprevotella sp._HMT_308 (SP335) 0.486824504222677 0.731811748494837 0.665231878586207 0 0 TRUE Lachnoanaerobaculum saburreum (SP34) 0.113487370947755 1.14415868188582 0.0991884891007459 0.920988614154768 1 FALSE Schaalia georgiae (SP350) -0.456024722557914 1.05858787293774 -0.430785893373573 0.666624057617178 1 FALSE Lancefieldella parvula (SP353) -1.49244977550038 1.34679871006868 -1.10814612780872 0.267798712330475 1 FALSE Gemella bergeri (SP354) -0.351581816009396 0.732911456562254 -0.47970571732976 0.631436661932979 1 FALSE Filifactor alocis (SP356) 0.950219648002983 1.00639114422937 0.9441852240568 0 0 TRUE Tannerella sp._HMT_286 (SP36) -1.33143770969841 1.0289452110244 -1.29398309592485 0.195671259788968 1 FALSE Actinomyces sp._HMT_896 (SP361) -0.769927072823116 1.28304561168245 -0.600077710264341 0.548454446763613 1 FALSE Leptotrichia shahii (SP365) -0.736475946005966 1.21724520752844 -0.605034993320158 0.545155745824065 1 FALSE Solobacterium moorei (SP369) 0.841714482298392 0.784223200287642 1.07330984595924 0 0 TRUE Capnocytophaga sp._HMT_338 (SP375) 0.669244330068862 0.739062289267757 0.905531698460668 0 0 TRUE Neisseria bacilliformis (SP38) -2.05105738958543 0.921676304818629 -2.22535545165072 0 0 TRUE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP40) -0.792753847384399 1.07118552032951 -0.740071474398329 0.459256626343485 1 FALSE Bifidobacterium dentium (SP401) 0.0203270933884094 1.32210184992724 0.0153748316663562 0.987733142474812 1 FALSE Granulicatella adiacens (SP42) -1.79581842318741 1.49185517427846 -1.20374849660321 0.228686801665109 1 FALSE Streptococcus constellatus (SP45) -0.30006960560388 1.17618401084516 -0.255121309962598 0.798629405655729 1 FALSE Anaeroglobus geminatus (SP46) 0.971120401945112 0.861843468100751 1.12679440976118 0 0 TRUE Capnocytophaga gingivalis (SP47) -0.283912800885306 1.29424336484095 -0.219365853901979 0.826365066871477 1 FALSE Actinomyces sp._HMT_897 (SP5) 0.405504982061157 1.22563351045729 0.330853373868556 0.740755242532294 1 FALSE Veillonella parvula (SP50) -2.20204614388942 1.7071572716196 -1.28989061552619 0.197088639559945 1 FALSE Streptococcus cristatus (SP51) -2.22010236166214 0.692764596866458 -3.20469950644735 0.00135203553122795 0.205509400746648 FALSE Bergeyella sp._HMT_322 (SP52) 0.239030355642089 1.124582272983 0.21255034992509 0.831677701441749 1 FALSE Streptococcus gordonii (SP53) 0.557119213761648 1.76553900508386 0.315551914830216 0.752342640459972 1 FALSE Cardiobacterium hominis (SP54) -0.596986768537562 1.31721680555624 -0.453218305459946 0.650391552352464 1 FALSE Porphyromonas pasteri (SP55) -1.70922835771511 1.13970192397475 -1.4997152516459 0.133688178135592 1 FALSE Dialister invisus (SP56) 1.51667417962036 1.14992669542464 1.31893118548768 0.187192119230953 1 FALSE Peptococcus sp._HMT_167 (SP57) -0.226498736504161 0.989234164553707 -0.228963722261195 0.818897112590022 1 FALSE Prevotella maculosa (SP59) -0.00748871417804131 0.858099925069764 -0.00872708872155242 0.993036879036055 1 FALSE Prevotella sp._HMT_317 (SP6) -0.71590265302311 1.07416652927994 -0.666472686970621 0.505109015960927 1 FALSE Treponema socranskii (SP60) 0.316844972277827 1.24953771599844 0.253569754815005 0.799827965225886 1 FALSE Prevotella oris (SP63) -0.0677447917353109 1.53862333127064 -0.0440294842528908 0.964880901615191 1 FALSE Prevotella dentalis (SP66) -0.224732175597987 0.825886964191781 -0.272110089324283 0.785537371999578 1 FALSE Actinomyces dentalis (SP69) 2.83323639192895 0.974366306369026 2.90777336347661 0 0 TRUE Veillonella atypica (SP7) 0.714468927294309 0.756104070478852 0.94493463954218 0 0 TRUE Leptotrichia hofstadii (SP71) -1.00414028192953 1.0897980503144 -0.921400328840601 0.356841457151543 1 FALSE Treponema sp._HMT_231 (SP74) 0.0199305845278241 1.11802330791127 0.0178266270361206 0.985777162830005 1 FALSE Prevotella sp._HMT_300 (SP75) 0.0599445661272479 0.823458031456199 0.0727961399820731 0.941968342656966 1 FALSE Actinomyces sp._HMT_175 (SP77) -0.744871503264269 1.25100316262444 -0.595419360652633 0.551563187185935 1 FALSE Capnocytophaga ochracea (SP78) -1.4124692019762 1.11959504260916 -1.26158936778115 0.207096583968192 1 FALSE Alloprevotella tannerae (SP79) -2.03113252650697 1.16715316794676 -1.74024505290948 0.081815997765343 1 FALSE Haemophilus parainfluenzae (SP81) -0.387736348558962 1.9598307617069 -0.197841750489347 0.843168879567791 1 FALSE Campylobacter concisus (SP84) 0.258208577272887 1.08672458768145 0.237602590573368 0.812189341064938 1 FALSE Actinomyces oris (SP85) -0.774843676267604 1.53010512702836 -0.506398980423285 0.612576590179548 1 FALSE Actinomyces sp._HMT_169 (SP9) -0.989817156908681 1.2557096838096 -0.788253184371212 0.430548625561274 1 FALSE Selenomonas noxia (SP90) -0.951322051070019 1.4021880458171 -0.678455399693307 0.497482993322983 1 FALSE Shuttleworthia satelles (SP92) -0.553571978338581 0.948356917882013 -0.5837169191267 0.559410782271281 1 FALSE Actinomyces sp._HMT_171 (SP93) 0.896345419446541 1.13287579156487 0.791212440163804 0.42882003327838 1 FALSE Prevotella histicola (SP96) -0.452940810630488 0.86176733503688 -0.525595241563784 0.5991694635989 1 FALSE Neisseria mucosa (SP98) -1.10375763218944 0.944149072606134 -1.16905016825652 0.242383419274583 1 FALSE Leptotrichia wadei (SP99) 0.0642240655870203 1.4576311895608 0.0440605731044844 0.964856120349543 1 FALSE Prevotella sp._HMT_305_nov_93.898% (SPN122) -0.0579639619824535 1.08017288602184 -0.0536617450155856 0.957204661918434 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) -1.93019489419079 1.24036363792056 -1.55615243399647 0.119671849096278 1 FALSE Porphyromonas uenonis_nov_94.667% (SPN15) -1.31092627115445 0.871000747283424 -1.50508053551402 0.132303372595176 1 FALSE Actinomyces oris_nov_97.588% (SPN157) -1.83340868480625 1.07874763375614 -1.69957145437475 0.0892115635258946 1 FALSE Aggregatibacter sp._HMT_458_nov_97.431% (SPN214) -0.836142336526713 1.27821925743481 -0.654146252032474 0.513017585451421 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.316664790703823 1.15831590437336 0.273383788919946 0.784558212891316 1 FALSE Corynebacterium matruchotii_nov_97.446% (SPN596) -0.286303185013424 1.22836636868163 -0.23307637876858 0.81570209683098 1 FALSE Corynebacterium matruchotii_nov_97.813% (SPN73) -0.783789781606724 1.25925044387985 -0.62242565441693 0.533662015692103 1 FALSE Prevotella sp._HMT_292_sp._HMT_300 (SPP26) -0.237202765797365 1.12767483719074 -0.210346775483865 0.833397030263311 1 FALSE Streptococcus infantis_infantis_clade_638 (SPP45) -0.323875912835674 1.11719047430971 -0.289902143173741 0.771891101988156 1 FALSE Veillonella dispar_parvula (SPP5) -0.569535982343223 1.58208760824441 -0.359990167026981 0.718854486882821 1 FALSE Capnocytophaga sp._HMT_324_sp._HMT_336 (SPP6) -0.515053358178017 0.942377059495417 -0.546547003652439 0.58468998698598 1 FALSE