Comp2Smoker 24 Weeks P2...1 Comp2Smoker 24 Weeks P2...2 Comp2Smoker 24 Weeks P2...3 Comp2Smoker 24 Weeks P2...4 Comp2Smoker 24 Weeks P2...5 Comp2Smoker 24 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Selenomonas sputigena (SP1) -1.37215602897959 0.498109327864348 -2.75472863530328 0.00587408325321259 0.957475570273653 FALSE Megasphaera micronuciformis (SP101) -0.019840501933352 0.346471677862882 -0.0572644265058917 0.954334557367846 1 FALSE Catonella morbi (SP103) -0.31482851092162 0.443856639700484 -0.709302244828572 0.478136935676172 1 FALSE Stomatobaculum longum (SP106) -0.100489443896713 0.397951788347727 -0.252516628493967 0.800641762791042 1 FALSE Oribacterium sp._HMT_078 (SP107) 0.35076818480704 0.478086646266457 0.73369165933897 0.463136683016171 1 FALSE Olsenella sp._HMT_807 (SP108) 0.33710766835863 0.584360332008353 0.576883217243793 0.564018348581832 1 FALSE Eikenella corrodens (SP109) 0.705368242911231 0.329053143835692 2.14363015860881 0.0320625323149982 1 FALSE Prevotella veroralis (SP111) -0.405226106420907 0.401689421289438 -1.00880452644263 0.31306838983081 1 FALSE Saccharibacteria_(TM7)_[G-2] bacterium_HMT_350 (SP116) -0.250859533844175 0.325124259988397 -0.771580483883695 0.4403629368554 1 FALSE Parvimonas sp._HMT_110 (SP119) -0.595671851984556 0.434765313812833 -1.37009975970851 0.170655762842051 1 FALSE Streptococcus mitis (SP12) -0.624490659960053 0.630116755901759 -0.991071343700971 0.321650744598203 1 FALSE Streptococcus parasanguinis_clade_411 (SP120) 0.135975434337633 0.56397608608181 0.241101418470265 0.809476513422867 1 FALSE Leptotrichia sp._HMT_417 (SP121) 0.322297723764695 0.400769356949882 0.804197522030109 0.42128290967899 1 FALSE Streptococcus sanguinis (SP123) 0.457016757523451 0.714257266672134 0.639848943578526 0.522270809617302 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) 0.00426515065684229 0.477783120153783 0.00892695969558213 0.992877411284684 1 FALSE Actinomyces israelii (SP126) 0.687950703377082 0.441903329154464 1.55679004431445 0.119520341673017 1 FALSE Streptococcus mutans (SP128) 0.0336903524308317 0.640082192021112 0.052634416096551 0.958023194886486 1 FALSE Actinomyces sp._HMT_170 (SP129) 0.912300892173814 0.512145850089204 1.78133024413829 0.0748585164600603 1 FALSE Schaalia odontolytica (SP13) 0.833272474019135 0.411371380741488 2.02559660936349 0.0428061392867296 1 FALSE Streptococcus oralis (SP131) -0.176152866164405 0.513125483922146 -0.343293934298403 0.731377343593502 1 FALSE Campylobacter showae (SP134) 0.546485987627717 0.351946544360655 1.552752815404 0.120482199194087 1 FALSE Streptococcus intermedius (SP136) 0.14691266078772 0.612439264177175 0.239881192113149 0.810422361739226 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP138) -0.957713718757304 0.545456521734035 -1.7558021228029 0.0791222018091803 1 FALSE Leptotrichia sp._HMT_215 (SP139) 0.242476063118739 0.328635668749047 0.737826371804755 0.460619965585517 1 FALSE Peptostreptococcus stomatis (SP140) -0.323768500485798 0.466707001605097 -0.693729683446561 0.487851747096512 1 FALSE Capnocytophaga sp._HMT_336 (SP142) 0.326727438241397 0.319528745693423 1.02252909212394 0.306530550691956 1 FALSE Treponema sp._HMT_268 (SP143) 0.221157323846883 0.272302530529834 0.812175059176148 0.41669118857032 1 FALSE Lautropia mirabilis (SP145) 0.647233789499994 0.500551440635101 1.29304150773951 0.195996703541412 1 FALSE Peptidiphaga sp._HMT_183 (SP146) 0.0377358520079118 0.478730664737468 0.0788248064882284 0.937171972709827 1 FALSE Rothia dentocariosa (SP147) 0.675740865536975 0.572401473512833 1.18053655835291 0.237786879127765 1 FALSE Porphyromonas catoniae (SP148) -0.0313662243285708 0.32344602785346 -0.0969751415305106 0.922746135572465 1 FALSE Gemella morbillorum (SP15) -0.651981491152711 0.514203711135561 -1.26794396273975 0.204817962902553 1 FALSE Prevotella pleuritidis (SP150) -0.0632099426134097 0.480011800911024 -0.13168414295949 0.895234128369035 1 FALSE Prevotella oulorum (SP151) -0.232044833337403 0.46478322194898 -0.499253893813909 0.617600531644704 1 FALSE Tannerella forsythia (SP153) 0.136715766704078 0.463460961799367 0.294988743330797 0.768002478815944 1 FALSE Prevotella loescheii (SP154) -0.2553835656821 0.386309390926983 -0.661085574620085 0.50855743578128 1 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP155) 0.560990177379838 0.335988314920845 1.66967168936218 0.0949843379839247 1 FALSE Bulleidia extructa (SP156) 0.270311450932213 0.314402543762197 0.859762289762731 0.389920090454899 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP16) 0.248815707291709 0.283211597277623 0.878550559664418 0.379645012589294 1 FALSE Rothia mucilaginosa (SP161) 0.583781581904269 0.473884883261367 1.2319058963995 0.21798423856029 1 FALSE Streptococcus anginosus (SP162) -0.690485379721153 0.577151221768393 -1.1963682197631 0.231552897492697 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_155 (SP163) 0.132340118273466 0.322900725836458 0.409847695234024 0.681917676223147 1 FALSE Parvimonas micra (SP166) -0.449844747486152 0.529803300041916 -0.849078794810379 0.395837448982499 1 FALSE Leptotrichia hongkongensis (SP171) -0.322476514151493 0.484958753126321 -0.664956580477462 0.50607826483716 1 FALSE Schaalia meyeri (SP173) 0.188915990461176 0.388350758547231 0.48645711718933 0.626643102493456 1 FALSE Porphyromonas gingivalis (SP176) -0.892528918312844 0.446035345807071 -2.00102733270583 0.0453894444318724 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP177) -0.554227147089699 0.510182988847069 -1.08633011920323 0.277332966171997 1 FALSE Bacteroidales_[G-2] bacterium_HMT_274 (SP18) 0.952071228656138 0.466394512890811 2.04134311691405 0.0412167341932306 1 FALSE Porphyromonas endodontalis (SP180) -0.602121146015547 0.518284126299788 -1.16175880267509 0.245333452651253 1 FALSE Capnocytophaga sputigena (SP181) 0.167717813794308 0.453812320961551 0.369575276050114 0.711698975643664 1 FALSE Arachnia propionica (SP182) -0.387062317578637 0.402700964483925 -0.961165608517156 0.336468905588538 1 FALSE Mycoplasma faucium (SP184) -0.390282494673401 0.333965466266899 -1.16863129303763 0.242552214684922 1 FALSE Campylobacter gracilis (SP185) -0.441550556712148 0.448287813106834 -0.984971136404549 0.324638248964128 1 FALSE Streptococcus salivarius (SP188) -0.146085933991282 0.508116945687257 -0.287504550342623 0.773726018281164 1 FALSE Desulfobulbus sp._HMT_041 (SP189) 0.190351171081552 0.304017822523266 0.626118460758942 0.531237244430234 1 FALSE Actinomyces massiliensis (SP19) 0.126838062189715 0.385157531517184 0.329314765545631 0.741917784703781 1 FALSE Gemella haemolysans (SP190) -0.0411939851370129 0.392450815267337 -0.104965981810871 0.916402802144814 1 FALSE Capnocytophaga sp._HMT_380 (SP192) -0.339173803397801 0.387046551505419 -0.876312686622794 0.380860070030607 1 FALSE Mogibacterium vescum (SP193) -0.447100515066281 0.29861375477161 -1.49725358568375 0.13432728699919 1 FALSE Fusobacterium nucleatum_subsp._vincentii (SP195) -0.239226250182292 0.507175134810921 -0.471683711922268 0.637152564895288 1 FALSE Selenomonas artemidis (SP197) -0.075715333962982 0.339324051252422 -0.223135771494894 0.823429838483189 1 FALSE Lachnoanaerobaculum orale (SP198) -0.341143182656884 0.430187462362301 -0.793010518678426 0.427771694388218 1 FALSE Treponema denticola (SP2) -0.8295662552529 0.40193689540979 -2.06392163726877 0.0390251468650496 1 FALSE Fusobacterium nucleatum (SP20) -0.398430435393069 0.32369754034328 -1.23087260709654 0.218370514280884 1 FALSE Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP201) -0.0677651059050789 0.30914602061315 -0.219200964549619 0.826493504152106 1 FALSE Ruminococcaceae_[G-1] bacterium_HMT_075 (SP204) 0.182206957188248 0.292235678747467 0.623493195523535 0.532960472374616 1 FALSE Neisseria elongata (SP205) 0.667883150497914 0.372597650397623 1.79250499777756 0.0730521093316499 1 FALSE Prevotella denticola (SP21) -1.47721692040669 0.537797186240474 -2.7467918356608 0.00601813179687576 0.974937351093873 FALSE Tannerella sp._HMT_808 (SP212) 0.403740165134256 0.313807461648826 1.28658561212311 0.198238761223945 1 FALSE Selenomonas infelix (SP213) 0.124936124252789 0.32373285978628 0.385923518345552 0.699553312252251 1 FALSE Selenomonas sp._HMT_137 (SP215) -0.349927230123653 0.288461905794777 -1.21307951966665 0.225099419367484 1 FALSE Pseudoramibacter alactolyticus (SP217) -0.416038219464111 0.338577869794068 -1.2287814904062 0.219153743156794 1 FALSE Mogibacterium timidum (SP22) -0.780023909330033 0.462636224765553 -1.68604157559283 0.0917877917770485 1 FALSE Prevotella sp._HMT_304 (SP220) -0.390124430045523 0.327296271235893 -1.19196112003472 0.233276490686376 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP222) 0.477778639172142 0.486291431834999 0.982494462979258 0.325856309449321 1 FALSE Lancefieldella rimae (SP227) 0.0707949149495479 0.511174230920934 0.138494686678559 0.889849468568477 1 FALSE Capnocytophaga endodontalis (SP228) 0.193494694406422 0.391497191807946 0.494242866756867 0.621134669134826 1 FALSE Prevotella melaninogenica (SP229) 0.208459957327639 0.47355671288078 0.440200617280912 0.659791812704085 1 FALSE Actinomyces sp._HMT_448 (SP230) -0.378108134071554 0.726302042939416 -0.520593515806885 0.602649967317209 1 FALSE Schaalia sp._HMT_178 (SP232) 1.21420539553983 0.307587317013497 3.9475145052439 0 0 TRUE Aggregatibacter sp._HMT_458 (SP234) -0.0393116801527019 0.370944437915704 -0.105977273506485 0.915600383740976 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP238) -0.460020959019915 0.485247963855923 -0.948012136649588 0.343123275668783 1 FALSE Corynebacterium durum (SP241) 0.614622525381731 0.417324778052462 1.47276787218339 0.140813638156544 1 FALSE Actinomyces naeslundii (SP244) 0.60224692074429 0.375501645406379 1.60384628965479 0.108747938328421 1 FALSE Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP247) -0.505056776823057 0.422513136527943 -1.19536348851405 0.231945044373584 1 FALSE Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP250) -0.114301068761051 0.302551668114447 -0.377790244798168 0.705586421133296 1 FALSE Lachnoanaerobaculum umeaense (SP254) -0.0443924284700414 0.290910161388561 -0.152598411338226 0.878714977894943 1 FALSE Cardiobacterium valvarum (SP261) 0.61785880526316 0.270378898519301 2.28515911798884 0.0223034993896031 1 FALSE Mogibacterium neglectum (SP263) 0.19963837837763 0.310230057045353 0.643517202294956 0.519888556280873 1 FALSE Peptidiphaga gingivicola (SP264) 0.0757717853231576 0.473859088432228 0.159903623614881 0.872956994020167 1 FALSE Schaalia sp._HMT_180 (SP266) 1.08990531687777 0.507977137517788 2.14557946879963 0.0319065449275302 1 FALSE Leptotrichia buccalis (SP27) -0.185397154843999 0.408507367576203 -0.453840418947681 0.649943689646467 1 FALSE Leptotrichia sp._HMT_498 (SP272) 0.258675808680306 0.330418854806649 0.782872420617993 0.433702034444292 1 FALSE Scardovia wiggsiae (SP277) -0.520803564762744 0.513779879998821 -1.01367061077584 0.31073995211396 1 FALSE Alloprevotella rava (SP28) -0.238813756756841 0.386444993789345 -0.617976065403556 0.536591116023571 1 FALSE Selenomonas sp._HMT_134 (SP280) -0.151997504873713 0.317410812313153 -0.478866815424531 0.632033379994541 1 FALSE Treponema sp._HMT_234 (SP287) -0.0175097583547991 0.264719357997092 -0.0661446087180047 0.947262695969 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_150 (SP294) 0.380796944476478 0.370945229851156 1.02655840763682 0.304628447443365 1 FALSE Kingella oralis (SP299) 0.989900499088785 0.515834235715143 1.91902830512288 0.0549807517671306 1 FALSE Capnocytophaga granulosa (SP3) 0.445833112227549 0.419194266937886 1.06354773285487 0.287533630733501 1 FALSE Prevotella oralis (SP300) 0.032586458443589 0.392531283004697 0.0830162075087378 0.933838652369524 1 FALSE Porphyromonas sp._HMT_275 (SP302) -0.0457712511271551 0.329990093469705 -0.138704924883926 0.889683326228345 1 FALSE Corynebacterium matruchotii (SP31) 1.60804987867809 0.57589995647022 2.79223823619311 0.00523448008896966 0.858454734591024 FALSE Rothia aeria (SP311) 1.16396981958621 0.425642846630233 2.73461619007867 0.0062453049682722 1 FALSE Oribacterium sinus (SP316) 0.158811387436805 0.3213151451896 0.494254285284604 0.621126605978399 1 FALSE Capnocytophaga leadbetteri (SP32) 0.679371972500938 0.474223463461989 1.4325988164763 0.151972520181842 1 FALSE Treponema lecithinolyticum (SP320) 0.671720843760656 0.277877792171991 2.41732467539147 0.0156350640812953 1 FALSE Fretibacterium fastidiosum (SP33) -0.531669295803533 0.39579356665217 -1.34329948892467 0.179175017535292 1 FALSE Prevotella salivae (SP331) -0.857442795479128 0.40135690981788 -2.13635986949421 0.0326500924150418 1 FALSE Lachnoanaerobaculum saburreum (SP34) -0.168016936472523 0.505316995561094 -0.332498091195133 0.739513180804279 1 FALSE Phocaeicola abscessus (SP348) -0.219223528483748 0.31033019970419 -0.70642022172742 0.47992684905167 1 FALSE Prevotella intermedia (SP35) -0.470263861678537 0.505684520159744 -0.929955027158004 0.352394370165311 1 FALSE Actinomyces johnsonii (SP351) 0.73669561584507 0.353390493749051 2.08465034820153 0.0371010507154266 1 FALSE Lancefieldella parvula (SP353) 0.26210050117714 0.4657095329154 0.562798230769204 0.573572285202025 1 FALSE Filifactor alocis (SP356) -0.442447610285936 0.445763828007821 -0.992560594840758 0.320924136060994 1 FALSE Tannerella sp._HMT_286 (SP36) 0.0662644942172997 0.368914002817778 0.179620436500565 0.857450559617271 1 FALSE Solobacterium moorei (SP369) 0.0169563041055367 0.403546811551214 0.0420181838145557 0.966484202330047 1 FALSE Actinomyces viscosus (SP372) -0.0323580344398376 0.387016760891006 -0.0836088710094664 0.933367413589853 1 FALSE Fusobacterium canifelinum (SP381) -0.246615225413931 0.270597249810855 -0.911373731944106 0.362098489279807 1 FALSE Treponema sp._HMT_237 (SP4) -0.469973093201876 0.409294475281072 -1.14825173948203 0.250864655728594 1 FALSE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP40) -0.515660252587432 0.526365831397469 -0.979661334054276 0.327253318335898 1 FALSE Peptostreptococcaceae_[XI][G-6] [Eubacterium]_nodatum (SP413) 0.11875750146707 0.352836504311408 0.336579407221018 0.736433981997761 1 FALSE Granulicatella adiacens (SP42) -0.202234577266254 0.590603413167811 -0.342420265032894 0.732034639963845 1 FALSE Streptococcus constellatus (SP45) -0.016774330257354 0.431831221341804 -0.0388446444544517 0.96901425054843 1 FALSE Anaeroglobus geminatus (SP46) -0.463617911225607 0.448999170806778 -1.03255850204035 0.301810556720673 1 FALSE Capnocytophaga gingivalis (SP47) 0.0120011536310962 0.485039791281141 0.0247426166818138 0.980260262277898 1 FALSE Treponema sp._HMT_257 (SP48) -0.205428835525584 0.328099880232674 -0.626116764748292 0.531238356781276 1 FALSE Actinomyces sp._HMT_897 (SP5) 0.4335944891952 0.456567515640973 0.949683177933669 0.342273259873596 1 FALSE Veillonella parvula (SP50) -0.533460644173658 0.566470393186408 -0.941727318126779 0.346332264998453 1 FALSE Streptococcus cristatus (SP51) -0.289446621669704 0.551185895429873 -0.525134304178744 0.599489830459409 1 FALSE Bergeyella sp._HMT_322 (SP52) 0.0340601156159323 0.434702721890842 0.0783526624074949 0.93754752763715 1 FALSE Streptococcus gordonii (SP53) 0.689751199320408 0.63206669106814 1.09126332563861 0.275157030310231 1 FALSE Cardiobacterium hominis (SP54) 0.223795652222528 0.408044297035685 0.54845920859165 0.583376630964504 1 FALSE Porphyromonas pasteri (SP55) -0.510587696949863 0.366296488714017 -1.39391916843762 0.163342015172584 1 FALSE Dialister invisus (SP56) -0.759818271214512 0.543135897070803 -1.39894688477102 0.161828911549693 1 FALSE Peptococcus sp._HMT_167 (SP57) -0.026308855714252 0.297861976659858 -0.0883256601237666 0.929617844824211 1 FALSE Fretibacterium sp._HMT_360 (SP58) 0.22542971721605 0.388727324962252 0.57991734241461 0.561970360093233 1 FALSE Prevotella maculosa (SP59) -0.462517706512879 0.385033505368851 -1.20124015199612 0.229658058326027 1 FALSE Prevotella sp._HMT_317 (SP6) -1.27587235101554 0.529014354456499 -2.41179155209569 0.0158743542936323 1 FALSE Treponema socranskii (SP60) -0.114275737517546 0.477054889467845 -0.239544211872601 0.810683618021087 1 FALSE Prevotella oris (SP63) -1.44319383541908 0.535340426905426 -2.69584317358876 0.00702107138936612 1 FALSE Prevotella multiformis (SP65) 0.195062370014161 0.35770532314372 0.545315815542917 0.58553632851426 1 FALSE Prevotella dentalis (SP66) -0.563212486709958 0.291302696801217 -1.93342695723236 0.0531836230840998 1 FALSE Neisseria sicca (SP67) 0.663478976237316 0.385765974173796 1.71990020026599 0.0854505841323799 1 FALSE Actinomyces dentalis (SP69) 0.70759602145693 0.46842522333576 1.51058479818397 0.130894269495596 1 FALSE Veillonella atypica (SP7) -0.603488200752303 0.340309151336928 -1.77335284220674 0.0761702580043692 1 FALSE Prevotella sp._HMT_314 (SP70) -0.316117084735737 0.361081738536188 -0.875472368160361 0.381316938585134 1 FALSE Treponema sp._HMT_231 (SP74) -0.0907674839328654 0.348091575587382 -0.260757485382118 0.794279532157729 1 FALSE Prevotella sp._HMT_300 (SP75) -1.24699221854823 0.457542152435846 -2.72541494135467 0.00642207213086672 1 FALSE Actinomyces sp._HMT_175 (SP77) 0.588309371923478 0.578415789883228 1.01710461957176 0.309103662935581 1 FALSE Capnocytophaga ochracea (SP78) -0.700783509400721 0.389450169369269 -1.79941765216245 0.0719526393391342 1 FALSE Alloprevotella tannerae (SP79) -1.35794849030157 0.53306158591308 -2.54745141309619 0.0108512962728369 1 FALSE Haemophilus parainfluenzae (SP81) 1.74929467017028 0.606232229954942 2.88551908614344 0.00390768766871402 0.644768465337813 FALSE Campylobacter concisus (SP84) 0.487761854077019 0.427891877402092 1.13991846968076 0.254320269505368 1 FALSE Actinomyces oris (SP85) 0.558804543588319 0.560177531274925 0.997549013286054 0.318498095522792 1 FALSE Bacteroidetes_[G-5] bacterium_HMT_511 (SP86) 0.20485160609049 0.294574911882799 0.695414299816521 0.486795701540366 1 FALSE Streptococcus sp._HMT_064 (SP88) 0.210844255833854 0.543129520860487 0.38820253316338 0.697866158696228 1 FALSE Actinomyces sp._HMT_169 (SP9) 0.184662876124773 0.661044767464414 0.279350030759776 0.779976214812884 1 FALSE Selenomonas noxia (SP90) -0.551107307206347 0.48078023514799 -1.14627696173224 0.251680572287019 1 FALSE Actinomyces sp._HMT_525 (SP91) 0.106972244227493 0.438579316801717 0.24390626764521 0.807303414879285 1 FALSE Actinomyces sp._HMT_171 (SP93) 0.00152807212862623 0.442931302371686 0.00344990774064541 0.997247377337769 1 FALSE Leptotrichia wadei (SP99) -0.303545512884318 0.593543807226864 -0.511412147154787 0.609062490933107 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) -0.549654785530912 0.435891520259463 -1.26098985638383 0.207312501793969 1 FALSE Streptococcus sanguinis_nov_97.727% (SPN14) -0.0480132285921436 0.478026236763221 -0.100440571875819 0.919994560905229 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.145288746740996 0.444290685745294 0.327012812562737 0.74365819449858 1 FALSE Veillonella dispar_parvula (SPP5) -0.641996320239411 0.31938879487942 -2.01007778147566 0.0444229572311115 1 FALSE