Comp8DUS 24 Weeks P2...1 Comp8DUS 24 Weeks P2...2 Comp8DUS 24 Weeks P2...3 Comp8DUS 24 Weeks P2...4 Comp8DUS 24 Weeks P2...5 Comp8DUS 24 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Selenomonas sputigena (SP1) 0.281568599002675 0.621482314966907 0.453059712596437 0.650505744379292 1 FALSE Catonella morbi (SP103) 0.118253362088406 0.596815116673096 0.198140695141238 0.84293498584709 1 FALSE Leptotrichia sp._HMT_212 (SP104) -0.235726459214927 0.475093790009901 -0.49616826018714 0.61977570250225 1 FALSE Stomatobaculum longum (SP106) -0.67852022994739 0.564643854615258 -1.20167823381294 0.229488217404353 1 FALSE Oribacterium sp._HMT_078 (SP107) -0.367200833439313 0.635532724413583 -0.577784304935887 0.563409752944334 1 FALSE Olsenella sp._HMT_807 (SP108) 1.25967276136927 0.731421999355501 1.72222432806129 0.0850288894561139 1 FALSE Eikenella corrodens (SP109) 0.193701685708133 0.561005572583203 0.345275867432502 0.729886987388176 1 FALSE Prevotella veroralis (SP111) -0.779116807131283 0.500744100466162 -1.55591809550222 0.119727569834899 1 FALSE Colibacter massiliensis (SP113) -0.266735042527444 0.463766776964792 -0.575149096002825 0.565190466211839 1 FALSE Parvimonas sp._HMT_110 (SP119) 0.446419378889264 0.553258876785882 0.806890585258577 0.41972952343359 1 FALSE Streptococcus mitis (SP12) -0.985246173867853 0.713473633749764 -1.38091462285684 0.167305213271531 1 FALSE Streptococcus parasanguinis_clade_411 (SP120) -1.09984980761321 0.792188761579759 -1.38836835480968 0.16502490740809 1 FALSE Leptotrichia sp._HMT_417 (SP121) 0.493335981786085 0.479086417741401 1.029743201888 0.303130569622235 1 FALSE Streptococcus sanguinis (SP123) 0.0385701561101333 0.852678797679934 0.0452340977811098 0.963920715957069 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP125) -0.0810142525974954 0.605409074159465 -0.133817374161386 0.893546988170115 1 FALSE Streptococcus mutans (SP128) 0.845530515605682 0.944642391697089 0.895080003859081 0.37074432232651 1 FALSE Actinomyces sp._HMT_170 (SP129) 0.302482936173147 0.633770674259746 0.477275059352426 0.633166268431171 1 FALSE Schaalia odontolytica (SP13) 0.260485837539985 0.558258367897292 0.466604447903071 0.640782904134067 1 FALSE Streptococcus oralis (SP131) -0.168913838295812 0.742002783133322 -0.227645828473209 0.819921589233656 1 FALSE Capnocytophaga sp._HMT_864 (SP132) -0.491424077885767 0.436398397393419 -1.12609047334044 0.260127226024868 1 FALSE Campylobacter showae (SP134) 0.203935615405301 0.597864854455606 0.341106545878161 0.733023373546013 1 FALSE Streptococcus intermedius (SP136) 0.0933842227505209 0.747231382018374 0.124973636008538 0.900544422096961 1 FALSE Streptococcus oralis_subsp._tigurinus_clade_070 (SP138) -0.991288107534735 0.72499933509052 -1.36729519539624 0.171532797071302 1 FALSE Leptotrichia sp._HMT_215 (SP139) -0.144591690859707 0.477890963347663 -0.302562094597544 0.762223605309959 1 FALSE Peptostreptococcus stomatis (SP140) -0.316206129752325 0.570816434539891 -0.553954144658088 0.579610228380113 1 FALSE Capnocytophaga sp._HMT_336 (SP142) -0.856694851617426 0.533829359848704 -1.60481029342453 0.108535559994127 1 FALSE Lautropia mirabilis (SP145) 0.265164424907814 0.62422271499454 0.424791374197483 0.670988766299451 1 FALSE Peptidiphaga sp._HMT_183 (SP146) -0.315419001573055 0.836746840245901 -0.376958700531646 0.706204296898766 1 FALSE Rothia dentocariosa (SP147) 1.82970373100523 0.811976687740904 2.25339441221627 0.0242342915439089 1 FALSE Porphyromonas catoniae (SP148) -0.10094654507666 0.4614318782452 -0.218768034537523 0.826830748459161 1 FALSE Gemella morbillorum (SP15) -0.328471957778722 0.647825497692481 -0.507037711465079 0.612128358448909 1 FALSE Prevotella pleuritidis (SP150) 0.195956371953248 0.599153402766944 0.327055426954606 0.743625963617811 1 FALSE Prevotella oulorum (SP151) -0.0993872464937483 0.541651561945276 -0.183489264088542 0.854414141788813 1 FALSE Tannerella forsythia (SP153) -0.173148403421998 0.514772512941053 -0.336359069431948 0.73660011100608 1 FALSE Prevotella loescheii (SP154) 0.0627181717926974 0.502188150918211 0.124889788176049 0.900610802927546 1 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP155) 0.479177449710362 0.520057801745505 0.921392676164202 0.356845451092024 1 FALSE Bulleidia extructa (SP156) -0.161284711937897 0.393782497875372 -0.409578162584925 0.682115418753495 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_957 (SP16) -0.16458533818438 0.440816761104803 -0.37336451947037 0.708877162708838 1 FALSE Mycoplasma salivarium (SP160) 0.092541092832066 0.37114784239306 0.24933754763435 0.803099689438077 1 FALSE Streptococcus anginosus (SP162) 0.229122766809807 0.732482727902315 0.312802961874567 0.75443036498313 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_155 (SP163) -0.0775181479606183 0.466950783332212 -0.166009247071908 0.868149673040213 1 FALSE Parvimonas micra (SP166) 0.123970209300423 0.688025233536464 0.18018264920781 0.85700917942723 1 FALSE Treponema sp._HMT_262 (SP167) 0.503244975226833 0.355575004840588 1.41529907438924 0.156980826287018 1 FALSE Leptotrichia hongkongensis (SP171) -0.504595528060618 0.634120848566275 -0.795740321740707 0.426182985213181 1 FALSE Schaalia meyeri (SP173) 0.0950110760292785 0.549051347650876 0.17304588438911 0.862615361098273 1 FALSE Porphyromonas gingivalis (SP176) -0.141687561897478 0.452846411589274 -0.312882156668135 0.754370194376413 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP177) 0.917098349804982 0.60662984546179 1.51179233376962 0.13058670028409 1 FALSE Bacteroidales_[G-2] bacterium_HMT_274 (SP18) -0.0662733889103446 0.552690760210323 -0.11991043397419 0.90455409900097 1 FALSE Porphyromonas endodontalis (SP180) -0.393375445321759 0.634710384512556 -0.61977156025872 0.535408194985415 1 FALSE Capnocytophaga sputigena (SP181) 0.0582726859470942 0.536744017319295 0.108566996681454 0.913545938813063 1 FALSE Arachnia propionica (SP182) 0.335851114384568 0.51442419134818 0.652868041653298 0.513841353544779 1 FALSE Mycoplasma faucium (SP184) -0.189407035913173 0.422748507938035 -0.448037148225572 0.654126386891619 1 FALSE Campylobacter gracilis (SP185) 0.260721061079186 0.62269514751806 0.418697756226894 0.675437035716069 1 FALSE Streptococcus salivarius (SP188) 0.502329361094202 0.661276531244042 0.759635851811017 0.447472282683819 1 FALSE Gemella haemolysans (SP190) 0.661139331098686 0.599815946603642 1.10223700260434 0.270358649135207 1 FALSE Capnocytophaga sp._HMT_380 (SP192) -0.457347268449652 0.43268159381494 -1.05700652624771 0.290508608953584 1 FALSE Mogibacterium vescum (SP193) -0.449868533087095 0.443630033781353 -1.01406239170186 0.310552981992138 1 FALSE Fusobacterium nucleatum_subsp._vincentii (SP195) -0.593031888917334 0.570278023070188 -1.0398996014692 0.298386547653121 1 FALSE Selenomonas artemidis (SP197) 0.320004302242885 0.427434570466248 0.748662659395617 0.454060555213273 1 FALSE Lachnoanaerobaculum orale (SP198) -0.109893652501252 0.428330285220181 -0.256562882180422 0.797516231745909 1 FALSE Prevotella marshii (SP199) 0.358395682194916 0.385740846319456 0.929110011590805 0.352832076554348 1 FALSE Treponema denticola (SP2) -0.485624062749345 0.535753158954715 -0.90643247665926 0.36470698955533 1 FALSE Fusobacterium nucleatum (SP20) 0.0525695488300382 0.398233647763549 0.132006798333754 0.894978914516802 1 FALSE Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP201) -0.295084650380288 0.45272327811036 -0.651799155572369 0.514530746473858 1 FALSE Ruminococcaceae_[G-1] bacterium_HMT_075 (SP204) -0.0603393896566193 0.457404204799541 -0.131916998189956 0.89504994351737 1 FALSE Neisseria elongata (SP205) 0.0663158586462336 0.382235526347593 0.17349475408502 0.862262550990625 1 FALSE Prevotella denticola (SP21) 1.06363496616519 0.708170966524875 1.50194658697269 0.13311090376285 1 FALSE Ruminococcaceae_[G-2] bacterium_HMT_085 (SP211) -0.486682217806347 0.483625945386332 -1.00631949639834 0.314261904905727 1 FALSE Tannerella sp._HMT_808 (SP212) -0.350328035943472 0.453634468230241 -0.772269438233394 0.439954862427313 1 FALSE Selenomonas sp._HMT_137 (SP215) -0.481813265772151 0.407233213493486 -1.18313843224837 0.236754288578488 1 FALSE Prevotella sp._HMT_301 (SP216) -0.0365168541768571 0.367191229088803 -0.0994491460688613 0.920781663211682 1 FALSE Mogibacterium timidum (SP22) -0.347685667040013 0.510470621929407 -0.681108083607002 0.4958031024973 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP222) 0.156899036781765 0.596363821709582 0.263092815275056 0.79247904151612 1 FALSE Lancefieldella rimae (SP227) -0.112802583563895 0.647127860559866 -0.174312667463125 0.861619744451768 1 FALSE Capnocytophaga endodontalis (SP228) -0.112374771646369 0.665765806873214 -0.168790241983348 0.865961633966919 1 FALSE Prevotella melaninogenica (SP229) -0.470207342454728 0.535677869870515 -0.877780040770375 0.380063097969569 1 FALSE Actinomyces sp._HMT_448 (SP230) 0.458386599480281 0.834186923834802 0.549501060713171 0.5826616368466 1 FALSE Streptococcus oralis_subsp._dentisani_clade_058 (SP231) -0.246797657575169 0.508640709292202 -0.485210194674743 0.627527251169029 1 FALSE Schaalia sp._HMT_178 (SP232) 0.183464375431126 0.515063057457801 0.356197892228287 0.721692370325669 1 FALSE Prevotella saccharolytica (SP233) 0.118606901328635 0.403952105070556 0.293616247668567 0.769051158920497 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP238) -0.426942450820825 0.624818681216108 -0.683306155299087 0.494413405500828 1 FALSE Selenomonas dianae (SP239) 0.312517999961439 0.443740135883344 0.704281570877777 0.481257440836491 1 FALSE Corynebacterium durum (SP241) 0.810062091621561 0.537190579612834 1.50796034473537 0.131564676575555 1 FALSE Actinomyces naeslundii (SP244) 0.110592837131001 0.567577172598769 0.194850748885175 0.845509791762181 1 FALSE Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP247) 0.208742034321426 0.411288913860157 0.507531390433735 0.61178201695085 1 FALSE Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP250) -0.127275201719161 0.454286137223619 -0.28016527754293 0.779350704812175 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_132 (SP259) 0.355340531179347 0.373037489704404 0.952559839122122 0.34081313368206 1 FALSE Bergeyella sp._HMT_900 (SP26) -0.0129097603066914 0.497261028767242 -0.0259617375178101 0.979287857193883 1 FALSE Cardiobacterium valvarum (SP261) 0.0203518702971681 0.477369498795557 0.0426333696403259 0.965993794537924 1 FALSE Mogibacterium neglectum (SP263) 0.0206178857483322 0.43417399389998 0.0474876110453587 0.962124604150579 1 FALSE Peptidiphaga gingivicola (SP264) 0.477971392951433 0.508549767756063 0.939871421159908 0.347283518226045 1 FALSE Prevotella sp._HMT_315 (SP265) -0.350117220458175 0.367325517160756 -0.953152460423681 0.340512829228469 1 FALSE Schaalia sp._HMT_180 (SP266) 0.20251198804338 0.634210112716087 0.319313716358284 0.749488632542006 1 FALSE Leptotrichia buccalis (SP27) -0.312729348172993 0.560589684169025 -0.557857836140098 0.576941465263568 1 FALSE Prevotella buccae (SP273) 0.257897190857804 0.447030626475511 0.576911682519658 0.563999118260542 1 FALSE Scardovia wiggsiae (SP277) 0.025937897134778 0.651312303508489 0.0398240552113874 0.96823339815561 1 FALSE Selenomonas sp._HMT_134 (SP280) -0.227269077847792 0.481201378214118 -0.472295151546023 0.636716130599427 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_150 (SP294) 0.367425636443243 0.370253659360816 0.992361931216413 0.321021002395421 1 FALSE Kingella oralis (SP299) 0.711538576703142 0.67620341416041 1.05225522646407 0.292682467736933 1 FALSE Capnocytophaga granulosa (SP3) -0.734227539662108 0.633957878633648 -1.15816454753204 0.24679689299957 1 FALSE Corynebacterium matruchotii (SP31) 1.72051124315262 0.782572659315462 2.19853226747993 0.0279111977233714 1 FALSE Rothia aeria (SP311) 0.604783607290438 0.531652915521992 1.13755344818648 0.255306994441501 1 FALSE Capnocytophaga leadbetteri (SP32) -0.299562052301153 0.687526937384249 -0.435709549709951 0.663047476156177 1 FALSE Treponema lecithinolyticum (SP320) -0.367208993549493 0.408805339763964 -0.898249014461289 0.369052807675663 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_348 (SP323) 0.154475621429511 0.404783505342798 0.381625287074608 0.702739324961591 1 FALSE Absconditabacteria_(SR1)_[G-1] bacterium_HMT_345 (SP324) -0.174697475054774 0.437494231135664 -0.399313779752677 0.689662014966647 1 FALSE Fretibacterium fastidiosum (SP33) 0.10761789943448 0.543374969385138 0.198054576485656 0.843002363497847 1 FALSE Prevotella salivae (SP331) -0.596748947822716 0.544442690891599 -1.09607302624535 0.273046817848658 1 FALSE Lachnoanaerobaculum saburreum (SP34) -0.18484533304074 0.698945050361833 -0.264463326473302 0.791422920320954 1 FALSE Prevotella intermedia (SP35) 0.0492698999847117 0.478982127647053 0.102863754492771 0.918071104783634 1 FALSE Lancefieldella parvula (SP353) 0.476795671090431 0.606942962872 0.785569156011425 0.432119940364959 1 FALSE Filifactor alocis (SP356) -0.0437063059089672 0.433541956946362 -0.10081217102218 0.919699564987486 1 FALSE Tannerella sp._HMT_286 (SP36) -0.835613832946346 0.439915308052743 -1.89948796427462 0.0575003476083629 1 FALSE Solobacterium moorei (SP369) 0.0548616666881791 0.486992146124754 0.112654109773107 0.910304784655396 1 FALSE Neisseria bacilliformis (SP38) 0.710760611143964 0.446014729421923 1.59358102828841 0.111029906511994 1 FALSE Treponema sp._HMT_237 (SP4) -0.210860138397967 0.546703559711121 -0.385693735942356 0.699723502562873 1 FALSE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP40) 0.238854222657993 0.709296478497019 0.336748073477143 0.736306820316719 1 FALSE Bifidobacterium dentium (SP401) 0.124814990720899 0.4565802703585 0.273369216376554 0.784569413638175 1 FALSE Granulicatella adiacens (SP42) -0.339020912415631 0.744927606367102 -0.455105851250411 0.649033088699151 1 FALSE Aggregatibacter sp._HMT_513 (SP43) -0.29966742191491 0.492231482692378 -0.608793692503793 0.542661194952872 1 FALSE Streptococcus constellatus (SP45) 0.404360130800826 0.481098663924668 0.840493148540821 0.400631941511522 1 FALSE Anaeroglobus geminatus (SP46) 0.534544845226635 0.437463542080278 1.22191861448546 0.221738405402934 1 FALSE Capnocytophaga gingivalis (SP47) -0.612782246882674 0.647427348896028 -0.946488046770915 0.343899716142026 1 FALSE Treponema sp._HMT_257 (SP48) 0.00810209113806129 0.394374790261314 0.0205441405945163 0.983609300393906 1 FALSE Actinomyces sp._HMT_897 (SP5) 0.751090379649434 0.553294167717065 1.35748833707843 0.174626096770288 1 FALSE Veillonella parvula (SP50) 0.462477811591381 0.738440772352359 0.626289648278931 0.531124974905474 1 FALSE Streptococcus cristatus (SP51) -0.577710573361778 0.723936045897088 -0.798013272907125 0.424862787756016 1 FALSE Bergeyella sp._HMT_322 (SP52) -0.287774198255815 0.615108542758222 -0.467842954944831 0.639896900069237 1 FALSE Streptococcus gordonii (SP53) 0.643268132813922 0.860306114291739 0.747720052348463 0.454629033415197 1 FALSE Cardiobacterium hominis (SP54) 0.496356883122783 0.522600367586394 0.949782881736546 0.342222585716799 1 FALSE Porphyromonas pasteri (SP55) -1.15049056769747 0.54803991749668 -2.09928242627407 0.0357920116499389 1 FALSE Dialister invisus (SP56) -0.287431453321724 0.666968423394954 -0.430952115931757 0.666503188026767 1 FALSE Prevotella maculosa (SP59) -0.588749678596371 0.527131852191709 -1.11689262591222 0.264040237944701 1 FALSE Prevotella sp._HMT_317 (SP6) -0.871871075503737 0.712814132120529 -1.22313943595652 0.221277035867411 1 FALSE Treponema socranskii (SP60) 0.115262053429297 0.610424436142152 0.188822803617998 0.850231698631103 1 FALSE Prevotella oris (SP63) -0.157773779297811 0.689999702495806 -0.22865774974558 0.819134935601285 1 FALSE Actinomyces dentalis (SP69) 1.46592081391777 0.619689900744285 2.36557157403584 0.0180022631935999 1 FALSE Prevotella sp._HMT_314 (SP70) -0.396960301218198 0.494004514033794 -0.803556020119772 0.421653431326822 1 FALSE Leptotrichia hofstadii (SP71) -0.367029928554782 0.515913948962141 -0.711416951011176 0.476825897849105 1 FALSE Treponema sp._HMT_231 (SP74) -0.0802585416322426 0.474439365715896 -0.169165013343988 0.865666848442101 1 FALSE Prevotella sp._HMT_300 (SP75) -0.178335781422734 0.584559408139964 -0.305077258084322 0.760307311494109 1 FALSE Actinomyces sp._HMT_175 (SP77) -0.544082627265012 0.634263127048313 -0.857818473221081 0.390992707475908 1 FALSE Capnocytophaga ochracea (SP78) 0.141278489964627 0.489179776757595 0.288806889976229 0.772729159249872 1 FALSE Alloprevotella tannerae (SP79) -0.287989933833128 0.678467930293161 -0.424470960195111 0.671222379497253 1 FALSE Haemophilus parainfluenzae (SP81) -0.235790480544113 0.779805065470607 -0.302371055260862 0.762369217228359 1 FALSE Campylobacter concisus (SP84) -0.0545301150272506 0.572649654142707 -0.0952242171679746 0.924136734868229 1 FALSE Actinomyces oris (SP85) -0.171997532094849 0.711916850262194 -0.241597782144788 0.809091840779464 1 FALSE Streptococcus sp._HMT_064 (SP88) 0.13763885269095 0.825558701525228 0.166722066446227 0.867588742032383 1 FALSE Actinomyces sp._HMT_169 (SP9) 0.531735212875315 0.87581539834911 0.607131610014647 0.54376357399481 1 FALSE Selenomonas noxia (SP90) -0.574738989684997 0.615906215630934 -0.933159911523598 0.350737409595917 1 FALSE Shuttleworthia satelles (SP92) 0.241479918536829 0.483117608021901 0.499836715795882 0.617190055558283 1 FALSE Actinomyces sp._HMT_171 (SP93) 0.693071104626529 0.660865928713301 1.04873178433624 0.294301581253531 1 FALSE Leptotrichia wadei (SP99) -0.120079944987808 0.766531492541858 -0.156653635442448 0.875517829368176 1 FALSE Actinomyces sp._HMT_175_nov_97.633% (SPN133) 0.181894372025685 0.76422633087596 0.238011129264804 0.811872462312853 1 FALSE Streptococcus sanguinis_nov_97.727% (SPN14) 0.300687724859139 0.466978070332661 0.643901167874838 0.519639524431074 1 FALSE Selenomonas infelix_nov_97.248% (SPN2) 0.110493068951653 0.39326595114349 0.280962713986236 0.778738998257526 1 FALSE Actinomyces viscosus_nov_95.849% (SPN249) 0.957005501333414 0.479940599235931 1.99400822280293 0.0461511559080117 1 FALSE Actinomyces israelii_nov_97.037% (SPN575) 0.204230486826647 0.398792220342337 0.512122545046963 0.608565246884949 1 FALSE Prevotella veroralis_nov_96.402% (SPN608) -0.113565811912237 0.435408252938824 -0.260826043479229 0.794226659623951 1 FALSE Prevotella sp._HMT_292_sp._HMT_300 (SPP26) 0.172293237100953 0.428278102340296 0.402292893704974 0.687468483900248 1 FALSE Veillonella dispar_parvula (SPP5) -0.641461233004545 0.625754225797948 -1.02510092071143 0.305315571153954 1 FALSE