Comp11OSS 24 Weeks P2...1 Comp11OSS 24 Weeks P2...2 Comp11OSS 24 Weeks P2...3 Comp11OSS 24 Weeks P2...4 Comp11OSS 24 Weeks P2...5 Comp11OSS 24 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) -0.470629513566365 2.0551028096388 -0.229005338009869 0.818864767237143 1 FALSE TannerellaTannerella forsythia (SP101) 0.893012845791225 1.22655526448827 0.728065723287078 0.466573354963075 1 FALSE PrevotellaPrevotella oralis (SP104) -0.394464879921033 1.23160711599361 -0.320284670978695 0.748752542403333 1 FALSE StomatobaculumStomatobaculum longum (SP105) -0.404745788613561 0.868324094759292 -0.466122950009536 0.641127496767384 1 FALSE GranulicatellaGranulicatella adiacens (SP107) -0.988504101267301 1.50094121983784 -0.658589482520905 0.510159418509594 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -2.58501351874217 0.979608586253614 -2.63882284722332 0 0 TRUE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.571616893887735 1.0561540848265 -0.541224904680113 0.588352573588918 1 FALSE PrevotellaPrevotella salivae (SP111) 0.126379792918036 1.09856767619133 0.115040516535301 0.908413007661736 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP114) 0.996194328971521 0.751736288158153 1.32519122019814 0 0 TRUE ActinomycesActinomyces sp._HMT_896 (SP115) -0.548790119326452 1.27285145740491 -0.431150167707176 0.666359184960752 1 FALSE VeillonellaVeillonella atypica (SP116) 0.935605880790974 0.751260023608572 1.24538222637872 0 0 TRUE HaemophilusHaemophilus haemolyticus (SP117) -1.79805870665453 0.977448118400516 -1.83954388248949 0 0 TRUE CatonellaCatonella morbi (SP118) 0.530984333309446 0.903716048856998 0.587556604733339 0.556829945889827 1 FALSE PrevotellaPrevotella oris (SP12) 0.153392161761354 1.53816019927413 0.0997244382176454 0.920563098360418 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) -0.0627758473886414 1.2969032396049 -0.0484044186733362 0.961393937842678 1 FALSE BifidobacteriumBifidobacterium dentium (SP121) 0.241464046885074 1.31866483639792 0.183112524289842 0.854709728961144 1 FALSE CampylobacterCampylobacter showae (SP122) 1.3802067391775 1.36699405972495 1.00966549880635 0.312655577370491 1 FALSE FretibacteriumFretibacterium fastidiosum (SP124) 1.14919905426697 0.829135145082131 1.38602139962736 0 0 TRUE PrevotellaPrevotella sp._HMT_300 (SP126) 0.281081519623912 0.803319730605265 0.34989993263595 0.726413797588565 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP128) 1.40408938136739 1.33909098988915 1.04853918962118 0.294390256299076 1 FALSE PrevotellaPrevotella veroralis (SP129) -1.80495624268167 1.07677917436019 -1.67625478432396 0 0 TRUE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.544361710416193 1.31697079294856 0.413343798762176 0.679354744607771 1 FALSE PeptococcusPeptococcus sp._Oral_Taxon_167 (SP133) -0.0053617830074964 0.983256355716097 -0.00545308756594964 0.995649087185676 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) -1.73766722511074 0.856605714187471 -2.02854965397819 0 0 TRUE BergeyellaBergeyella sp._HMT_900 (SP14) 0.849809966667292 1.10929141840364 0.766083603071806 0.443626558730398 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) -0.166599395062297 1.97234017493544 -0.0844678809362846 0.932684438852801 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) 0.368843849746267 1.17049313504412 0.315118336625157 0.752671806631313 1 FALSE NeisseriaNeisseria subflava (SP143) -1.28306543728462 0.738754030892383 -1.7367965298744 0 0 TRUE ActinomycesActinomyces viscosus (SP147) -2.06499757669705 1.45098997855223 -1.42316460294059 0.154688444192075 1 FALSE StreptococcusStreptococcus cristatus (SP15) -1.99896540816547 0.704440803449749 -2.8376627225116 0.00454451756945148 0.699855705695528 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.696545310893373 1.3261933632218 -0.52522153270411 0.599429197773003 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.0756557745827308 1.25519036145951 -0.0602743431639803 0.951937135973058 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) 0.460167309138753 1.12245064411428 0.409966631095721 0.681830425916458 1 FALSE PrevotellaPrevotella sp._HMT_306 (SP159) -0.699152732154188 0.884328801195942 -0.790602693487618 0.429175874575873 1 FALSE ScardoviaScardovia wiggsiae (SP166) 0.634368904171305 1.13900879676847 0.556948204413431 0.57756281827803 1 FALSE StreptococcusStreptococcus sanguinis (SP17) -0.85111540021013 1.44192902492245 -0.590261646377433 0.555015248409106 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.291896177925962 0.980460042785423 -0.297713486718647 0.765921849034185 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) 1.1174823729432 1.12786413413626 0.990795202295347 0.321785592480492 1 FALSE ActinomycesActinomyces naeslundii (SP172) 1.55431323687053 1.19798116361731 1.29744380302047 0 0 TRUE FusobacteriumFusobacterium periodonticum (SP173) -0.107578008927151 1.14080958439053 -0.0942997064533106 0.924871083093751 1 FALSE PrevotellaPrevotella histicola (SP174) -0.231803857133824 0.863296401553409 -0.26851016257767 0.788306653393119 1 FALSE StreptococcusStreptococcus anginosus (SP175) 0.536936290621403 1.40910795005159 0.381046952862443 0.703168408634028 1 FALSE KingellaKingella oralis (SP176) 0.262706248634286 1.43893825700851 0.182569507311899 0.855135811807904 1 FALSE HaemophilusHaemophilus sp._HMT_036 (SP177) 0.870202982005025 0.787685517683101 1.10475940266699 0 0 TRUE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 1.6173238628949 1.72830712778026 0.935784986880254 0.349383902822097 1 FALSE SelenomonasSelenomonas artemidis (SP180) -0.116767370337014 0.69889339498192 -0.167074651406649 0.86731131090108 1 FALSE NeisseriaNeisseria bacilliformis (SP182) -1.82992043608877 0.901756109425982 -2.02928532112038 0 0 TRUE GemellaGemella haemolysans (SP183) -2.71849420943315 1.0863691977973 -2.50236679661492 0 0 TRUE PorphyromonasPorphyromonas pasteri (SP184) -1.48809140421845 1.13612508325638 -1.30979539678259 0.190265060809795 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) 1.91686727441524 1.36044243786506 1.4090028516189 0.158834324930346 1 FALSE FusobacteriumFusobacterium nucleatum_ss_nucleatum (SP19) -0.351967520392722 0.899087460484478 -0.391471948905907 0.695448419156034 1 FALSE LeptotrichiaLeptotrichia sp._HMT_221 (SP191) -0.256343110752259 1.12947665614528 -0.22695742258819 0.820456850099242 1 FALSE RothiaRothia dentocariosa (SP193) 0.355153344561584 1.75274100159653 0.202627395740776 0.839426275463094 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_129 (SP197) -0.572912476943298 0.692436654996368 -0.82738611945132 0.408018245469401 1 FALSE EikenellaEikenella corrodens (SP200) 0.436049157580461 1.174245645636 0.371344070298242 0.710381277414257 1 FALSE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.598281048419349 1.5317389775523 -0.390589426258117 0.69610074263498 1 FALSE CampylobacterCampylobacter gracilis (SP205) 1.14453041607978 1.06736042378922 1.07229984414879 0.283585376762131 1 FALSE SelenomonasSelenomonas sputigena (SP21) 1.34693175929076 1.30179018948017 1.03467653249762 0.300819999156835 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) 0.371899009193722 1.13558358895069 0.327495934964475 0.743292817034497 1 FALSE LancefieldellaLancefieldella rimae (SP217) 0.266777161168775 1.40262375739664 0.190198661445696 0.849153459988061 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) -0.842061104129392 1.03034597507295 -0.817260536267702 0.413779554125241 1 FALSE LeptotrichiaLeptotrichia hofstadii (SP22) -0.783003328432868 1.08356789839392 -0.72261584123473 0.469915933086149 1 FALSE PrevotellaPrevotella pleuritidis (SP233) -1.10676376271306 1.21306504375174 -0.912369677466004 0.361574146203074 1 FALSE FilifactorFilifactor alocis (SP234) 1.17135660149965 1.0132232855093 1.15606956359166 0 0 TRUE CorynebacteriumCorynebacterium matruchotii (SP24) 0.406242754076801 1.12437662549411 0.361304873176525 0.717871551162139 1 FALSE NeisseriaNeisseria flavescens|subflava (SP240) -0.474351729234963 1.23602381977184 -0.383772320279817 0.701147205249097 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) -0.375849815040898 1.31042718371672 -0.286814727068534 0.774254185924902 1 FALSE ActinomycesActinomyces oris (SP249) -0.580621301086125 1.52078031660066 -0.381791699135063 0.70261587635062 1 FALSE SelenomonasSelenomonas dianae (SP252) -0.221363392805045 0.771828167009539 -0.286803983408277 0.774262412704857 1 FALSE AbiotrophiaAbiotrophia defectiva (SP256) 0.88467915602057 0.825969421513306 1.07107979179144 0 0 TRUE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) -1.81515733818702 1.10690338964979 -1.63985163941121 0.101036018159797 1 FALSE ArachniaArachnia propionica (SP260) -1.24312492130696 1.43502625676713 -0.866273293220092 0.386340308372879 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) 1.89508283892432 1.03893142200528 1.82406922996568 0 0 TRUE MogibacteriumMogibacterium neglectum (SP265) -1.48784300677067 0.870991993708849 -1.7082166283012 0.0875961542278149 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -1.59477428587539 1.19944797924446 -1.32959020605458 0.183653326773667 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_338 (SP269) 0.890381283565526 0.734878964044457 1.21160262727518 0 0 TRUE AlloprevotellaAlloprevotella tannerae (SP27) -1.80999557301031 1.15890707588805 -1.56181251341772 0.118332163034528 1 FALSE ShuttleworthiaShuttleworthia satelles (SP278) -0.332435024841917 0.949538440340568 -0.350101702804874 0.72626237301576 1 FALSE SolobacteriumSolobacterium moorei (SP279) 1.06285143579506 0.777034704325949 1.36783007229651 0 0 TRUE DialisterDialister invisus (SP28) 1.73781113311703 1.15390031953191 1.5060322834662 0.132058886389771 1 FALSE ColibacterColibacter massiliensis (SP283) -0.351389819063308 1.11119361892664 -0.316227355051529 0.751829945956733 1 FALSE ActinomycesActinomyces dentalis (SP286) 3.05437334542561 0.966107284571547 3.16152604809328 0 0 TRUE AnaeroglobusAnaeroglobus geminatus (SP287) 1.19225735544178 0.853964226544831 1.39614437980112 0 0 TRUE PrevotellaPrevotella sp._HMT_317 (SP29) -0.494765699526446 1.05547065135664 -0.468763104772743 0.639238974854708 1 FALSE ActinomycesActinomyces israelii (SP293) -0.381857613244352 1.49365065916758 -0.255653897985197 0.798218096388412 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_348 (SP304) -0.25443144683496 1.17073081561182 -0.217327026368564 0.827953496387854 1 FALSE ParvimonasParvimonas micra (SP31) -0.479485925079467 1.55453001818085 -0.308444301153201 0.757744276596931 1 FALSE ActinomycesActinomyces massiliensis (SP310) -2.00726189819696 1.05814137222676 -1.89696948903232 0 0 TRUE TreponemaTreponema denticola (SP311) 1.0722482498618 0.897269965275667 1.19501185970531 0 0 TRUE RothiaRothia mucilaginosa (SP318) -0.359668420696181 1.15494884506964 -0.311415022606039 0.755485134915806 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) -1.12465443833587 1.1788168426009 -0.954053588048899 0.340056517506689 1 FALSE CapnocytophagaCapnocytophaga granulosa (SP320) 0.756558936787709 1.60111247470473 0.47252079334853 0.636555103479629 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) -0.931382688317108 0.941168248597358 -0.989602751373271 0.322368324664842 1 FALSE PrevotellaPrevotella sp._HMT_292 (SP336) 1.00982438356687 0.820371293354367 1.23093578693844 0 0 TRUE CapnocytophagaCapnocytophaga leadbetteri (SP34) 1.50975289187706 1.17633632823432 1.28343642514484 0.199339219353872 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -1.95483149373513 1.21138305734374 -1.61371870102062 0.106588455688301 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) 0.667773781643194 1.89719642457105 0.351979253700193 0.724853821303329 1 FALSE NeisseriaNeisseria elongata (SP369) -0.562156056753703 0.974041329994339 -0.577137786090627 0.563846380411504 1 FALSE SelenomonasSelenomonas sp._HMT_134 (SP371) 0.825314159707761 0.718958234600742 1.14793060290363 0 0 TRUE StreptococcusStreptococcus salivarius (SP374) -1.7036418532469 1.17457010516266 -1.45043862921318 0.146936241473114 1 FALSE PorphyromonasPorphyromonas sp._Oral_Taxon_B94 (SP378) -1.08978931765778 0.866071399368483 -1.25831348137397 0.208278407492285 1 FALSE MycoplasmaMycoplasma salivarium (SP379) -0.812674514444566 0.827940516745323 -0.981561474535915 0.3263159349342 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) 0.241067538024488 1.10661721511651 0.217841846965219 0.827552338282513 1 FALSE Clostridiales_[F-1][G-1]Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP403) -0.234470580691563 0.983865192897632 -0.238315759500559 0.81163619911472 1 FALSE LeptotrichiaLeptotrichia shahii (SP420) -0.515338992509302 1.21748820642762 -0.423280480080725 0.67209063432164 1 FALSE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) -1.24641224052943 1.29315982562731 -0.963850110271407 0.335121079378442 1 FALSE NeisseriaNeisseria mucosa (SP44) -0.882620678692778 0.951721278384245 -0.927394079274155 0.353721963597813 1 FALSE GemellaGemella bergeri (SP450) -0.130444862512731 0.735322659975464 -0.177398126853705 0.859195678538167 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP455) 0.707961457719341 0.726959843755131 0.973865975955903 0 0 TRUE PrevotellaPrevotella dentalis (SP461) -0.00359522210132251 0.831916354456328 -0.00432161488599663 0.996551860937842 1 FALSE RothiaRothia aeria (SP465) -1.2540045075387 1.1070661941421 -1.13272766721096 0.257328635256577 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) -0.478408770658029 1.26577089817297 -0.377958421503111 0.705461481663012 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) 0.285361019083684 1.45684532539938 0.195875989103685 0.844707231130301 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -0.308418300846291 1.14539425703729 -0.269268244494307 0.787723267210748 1 FALSE AtopobiumAtopobium rimae (SP504) -0.456879040602159 0.99437558044213 -0.459463254718118 0.64590153338851 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) 0.375151587062816 1.69766395456381 0.220981064040561 0.825107177225186 1 FALSE StreptococcusStreptococcus mitis (SP52) -0.098691850802897 1.73826305413985 -0.0567761309589204 0.954723527995298 1 FALSE StreptococcusStreptococcus constellatus (SP53) -0.0789326521072154 1.17493602622651 -0.067180382884947 0.946438102028232 1 FALSE PrevotellaPrevotella maculosa (SP55) 0.213648239318623 0.838068726884552 0.254929258740917 0.79877773747913 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.974672913744377 1.4440635138698 -0.674951554680895 0.499706544423058 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.25818116583705 1.60005434936247 -0.161357747591462 0.871811643072796 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_150 (SP6) 1.25313174053344 0.900829458336667 1.391086546889 0 0 TRUE PrevotellaPrevotella denticola (SP60) -0.118138786319162 1.4326232651251 -0.0824632610645519 0.934278332221866 1 FALSE GemellaGemella sanguinis (SP61) -1.26809792419593 1.18080107926336 -1.07393018728187 0.282853972357123 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) -0.523734549767605 1.23749041458954 -0.423223116391831 0.672132482535246 1 FALSE TreponemaTreponema socranskii (SP63) 0.537981925774491 1.24120271844464 0.433435987353169 0.66469806095499 1 FALSE StreptococcusStreptococcus gordonii (SP64) -0.893247774897505 1.78271192357009 -0.501061199561997 0.616328052654212 1 FALSE CampylobacterCampylobacter concisus (SP67) 0.479345530769552 1.08162571464331 0.443171352418914 0.65764179830328 1 FALSE CorynebacteriumCorynebacterium durum (SP68) 0.138334336936899 1.55063225145425 0.0892115695434317 0.928913770875334 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) -0.92706175169774 1.09858276153208 -0.843870652407532 0.398741689294893 1 FALSE PeptoanaerobacterPeptoanaerobacter [Eubacterium] yurii (SP71) -0.383749154803467 0.856738906862079 -0.447918440180334 0.654212059544525 1 FALSE SelenomonasSelenomonas noxia (SP8) -0.730185097573354 1.37830420334882 -0.529770638295414 0.596270965053382 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -1.53329361770788 1.26103308913419 -1.21590276331339 0.224021965322942 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) 1.13524746015032 1.63302811924421 0.695179370625737 0.486942898853735 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.183997930397925 1.20521994623617 -0.152667511828475 0.878660482180625 1 FALSE StreptococcusStreptococcus infantis (SP87) -0.102738959339009 1.13588110311772 -0.0904486913788912 0.927930665100792 1 FALSE VeillonellaVeillonella parvula (SP88) -1.40592499449663 1.35636501317388 -1.03653882313492 0.299950837129004 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.374806953617918 1.22750515997485 0.305340430198759 0.760106886382033 1 FALSE SchaaliaSchaalia georgiae (SP91) -0.23488776906125 1.05894643663725 -0.221812700751088 0.824459691964661 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.606965176335348 1.49510749215947 0.405967583948546 0.684766418636026 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) 0.626641935557821 1.21698012453826 0.514915505128384 0.606612065528613 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) -0.996928397139686 1.05762303142037 -0.942612223374924 0.345879285312881 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) -1.19133224847953 1.12064044341173 -1.0630816114869 0.287744942719706 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) 1.43134483631114 1.11529653545866 1.28337602673759 0.199360368628567 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.537801744200488 1.16192574447428 0.46285379832411 0.643469166184433 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) -2.41230922489014 1.24096344673952 -1.94390030683675 0.0519074742578448 1 FALSE PrevotellaPrevotella sp._HMT_305_nov_93.898% (SPN590) 0.163172991514211 1.07607662338639 0.151636963361131 0.879473277960309 1 FALSE AggregatibacterAggregatibacter segnis_nov_96.402% (SPN84) -0.615005383030049 1.27651977797671 -0.481782886282289 0.629960187873153 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) -1.27131282200372 1.35014423265467 -0.941612600532349 0.346391016158525 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -1.33756791452138 1.18242864301568 -1.13120391866526 0.257969272979789 1 FALSE PrevotellaPrevotella sp._HMT_292_sp._HMT_300 (SPP5) -0.0160658123007011 1.12421306680371 -0.0142907183478826 0.98859804456212 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_324_sp._HMT_336 (SPP57) -0.293916404681353 0.962681112995176 -0.305310243146762 0.760129875246782 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) -0.460611773990495 0.787187535025974 -0.585136010792266 0.558456266926379 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.33462432444442 1.1335792410907 0.295192706706989 0.767846673098977 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) -0.306493113516171 1.40615004404651 -0.217966151488477 0.827455484547115 1 FALSE