Comp5OSS 12 Weeks P2...1 Comp5OSS 12 Weeks P2...2 Comp5OSS 12 Weeks P2...3 Comp5OSS 12 Weeks P2...4 Comp5OSS 12 Weeks P2...5 Comp5OSS 12 Weeks P2...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus mutans (SP100) 0.173061779693094 1.5012693005767 0.11527697237705 0.908225590048703 1 FALSE TannerellaTannerella forsythia (SP101) -0.412435411371916 0.6519255601014 -0.632641879093936 0.52696753233267 1 FALSE PrevotellaPrevotella oralis (SP104) -0.159590717471856 0.734149178640608 -0.217381864769451 0.827910763113981 1 FALSE StomatobaculumStomatobaculum longum (SP105) 0.183760783612714 0.838721018079917 0.219096433321055 0.826574929077548 1 FALSE GranulicatellaGranulicatella adiacens (SP107) 0.430029592642795 1.05885885208089 0.406125511249861 0.684650381931897 1 FALSE GranulicatellaGranulicatella paradiacens (SP108) -1.15422232392766 0.958542317495895 -1.20414331517774 0.228534190675426 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP110) -0.76149177252957 0.842106344696146 -0.904270318500375 0.365852081467234 1 FALSE PrevotellaPrevotella salivae (SP111) 0.949749248701985 0.667191371556839 1.42350349418611 0 0 TRUE HaemophilusHaemophilus haemolyticus (SP117) -0.10954294917359 0.714352145014275 -0.153345867214272 0.878125531571327 1 FALSE CatonellaCatonella morbi (SP118) -1.47825482915358 0.671954093732684 -2.1999342558387 0.0278115598590483 1 FALSE PrevotellaPrevotella oris (SP12) -0.98482058083457 1.11112370859145 -0.886328473796144 0.375440549779296 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP120) 0.564008171043903 0.859776021463654 0.655994301962218 0.511827790451478 1 FALSE PrevotellaPrevotella sp._HMT_300 (SP126) -0.206727253445115 0.64320457620396 -0.321402025254811 0.747905748542007 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP127) -1.24591158507622 0.579756559462552 -2.14902542237936 0 0 TRUE StreptococcusStreptococcus sp._str._2136FAA (SP128) -1.92530958212816 1.15311293970111 -1.66966262873366 0.094986131634421 1 FALSE PrevotellaPrevotella veroralis (SP129) -0.492766524979966 0.834973246446283 -0.590158459659902 0.555084418934093 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP130) 0.1966643528843 0.704103886478338 0.279311557088459 0.780005737822508 1 FALSE LachnoanaerobaculumLachnoanaerobaculum orale (SP139) 0.253368026473907 0.611341308341786 0.414446108935691 0.678547426720334 1 FALSE HaemophilusHaemophilus parainfluenzae (SP140) 0.64229086821471 1.18592079602714 0.541596766298726 0.588096319986395 1 FALSE OribacteriumOribacterium sp._Oral_Taxon_78 (SP142) -0.655186729775853 0.907396621457881 -0.722051101229789 0.470263060283642 1 FALSE NeisseriaNeisseria subflava (SP143) 0.260728729486964 0.615477054233001 0.423620552047843 0.671842564378094 1 FALSE ActinomycesActinomyces viscosus (SP147) 1.31191915926988 1.09123302729611 1.20223556880475 0.229272272146967 1 FALSE StreptococcusStreptococcus cristatus (SP15) 1.81626858967298 1.06179249135299 1.7105683120424 0.0871608328238672 1 FALSE PorphyromonasPorphyromonas gingivalis (SP152) -0.104211105840235 0.671113794570415 -0.155280828204316 0.876599929159021 1 FALSE StreptococcusStreptococcus sp._str._C150 (SP154) -1.16680528469835 1.3173717824677 -0.88570690539059 0.375775486272358 1 FALSE PorphyromonasPorphyromonas endodontalis (SP155) -0.234828456881335 0.864070700496224 -0.271769956725158 0.785798907097936 1 FALSE BergeyellaBergeyella sp._HMT_322 (SP158) -0.715753114927036 0.795268297827774 -0.900014645223595 0.368112456988923 1 FALSE PrevotellaPrevotella sp._HMT_306 (SP159) 0.169050293262933 0.650894562097643 0.259719934851096 0.795079814399719 1 FALSE TreponemaTreponema lecithinolyticum (SP162) -0.421175380606956 0.638911519454126 -0.659207680222764 0.509762415730739 1 FALSE ScardoviaScardovia wiggsiae (SP166) -1.35306801449761 1.21915479983337 -1.10984102649028 0.267067536810064 1 FALSE StreptococcusStreptococcus sanguinis (SP17) 1.1261194175688 1.27800732325024 0.881152554513411 0.378235255231602 1 FALSE ActinomycesActinomyces odontolyticus (SP170) -0.607079306999757 0.716738436778169 -0.847002582599946 0.396993681943114 1 FALSE ActinomycesActinomyces sp._HMT_171 (SP171) -1.13493615634725 0.937071555643915 -1.2111520721247 0.225837127497161 1 FALSE StreptococcusStreptococcus anginosus (SP175) -0.866555272177293 1.07013212276781 -0.809764751230919 0.418075394983241 1 FALSE KingellaKingella oralis (SP176) 0.857136307330736 1.0819639110894 0.792204156299175 0.428241645506236 1 FALSE HaemophilusHaemophilus sp._HMT_036 (SP177) 0.243872529532504 0.711807055314173 0.342610441568136 0.731891545780817 1 FALSE LeptotrichiaLeptotrichia sp._AF189244.1 (SP18) 0.644458616560878 1.0951862953001 0.588446567790814 0.556232588458635 1 FALSE GemellaGemella haemolysans (SP183) 1.32837515310904 0.918114728839211 1.44685093418394 0.147938677763982 1 FALSE PorphyromonasPorphyromonas pasteri (SP184) 0.970756408942303 0.889296457891762 1.09160044474219 0.275008760573672 1 FALSE OlsenellaOlsenella sp._Oral_Taxon_807 (SP189) -0.747102256448197 0.731227410152526 -1.02170986217866 0.306918241968437 1 FALSE LactobacillusLactobacillus salivarius (SP190) -0.210796310799392 1.25403803402874 -0.168094033098968 0.866509303458489 1 FALSE RothiaRothia dentocariosa (SP193) 0.966878956520468 1.34286756828932 0.720010654328465 0.471518435686768 1 FALSE TannerellaTannerella sp._HMT_808 (SP196) -1.19329842564324 0.578090920196016 -2.06420544581226 0 0 TRUE StreptococcusStreptococcus vestibularis (SP198) -0.250000171164352 0.844392369679163 -0.296071092233273 0.767175789866764 1 FALSE EikenellaEikenella corrodens (SP200) 0.959353102177588 0.553674466860456 1.73270244448418 0 0 TRUE ActinomycesActinomyces sp._str._ChDCB197 (SP201) -0.13472795317228 1.17573145409801 -0.114590753443472 0.90876950911116 1 FALSE CampylobacterCampylobacter gracilis (SP205) -0.236460304947178 1.00464261600156 -0.235367583637136 0.813923443904262 1 FALSE SelenomonasSelenomonas sputigena (SP21) 0.145621997149557 0.876841324716258 0.166075654790426 0.868097412745895 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP212) -2.32286044978226 0.911581741790596 -2.54816473750289 0.0108291319908251 1 FALSE LancefieldellaLancefieldella rimae (SP217) -1.17906374920921 1.0803328452137 -1.09138933841818 0.275101601727582 1 FALSE TannerellaTannerella sp._HMT_286 (SP218) 0.277478339327898 0.548892550442794 0.505523966583359 0.613190869547036 1 FALSE PeptococcusPeptococcus sp._HMT_167 (SP230) -1.17350315144231 0.610175421510877 -1.92322258496837 0 0 TRUE PrevotellaPrevotella pleuritidis (SP233) 0.483748031084234 0.78876170399733 0.613300606041938 0.539677592738378 1 FALSE CorynebacteriumCorynebacterium matruchotii (SP24) 0.965483025928448 1.18390273287947 0.815508739962289 0.414781163807146 1 FALSE CardiobacteriumCardiobacterium hominis (SP242) 0.559704116022707 0.695110281100393 0.805201895642615 0.420703182752149 1 FALSE LautropiaLautropia mirabilis (SP245) 0.0422382129700857 0.863184290303955 0.0489330186433447 0.960972675298753 1 FALSE StreptococcusStreptococcus sobrinus (SP246) 0.0468746919274426 0.90466005399587 0.0518147029045859 0.958676340065195 1 FALSE ActinomycesActinomyces oris (SP249) 0.0943171287584813 1.05196446143738 0.0896580941808702 0.928558917767759 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_335 (SP255) -0.370886582689085 0.697258718485844 -0.531921040004341 0.59478068430707 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP259) 0.57811050303946 0.669899403850427 0.862981068077706 0.38814787606283 1 FALSE ArachniaArachnia propionica (SP260) 0.922511509879255 0.647445348964501 1.42484846227513 0.154201010079758 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_180 (SP262) -0.817086245564848 1.09325553693825 -0.747388161283099 0.454829289480215 1 FALSE MogibacteriumMogibacterium neglectum (SP265) -0.43708957650047 0.710673670519105 -0.615035556588443 0.538531238977263 1 FALSE CapnocytophagaCapnocytophaga endodontalis (SP268) -0.644531832808091 0.972677729308853 -0.662636568502571 0.507563343768127 1 FALSE AlloprevotellaAlloprevotella tannerae (SP27) -0.110341809646933 0.924240557416968 -0.119386461415751 0.904969186805121 1 FALSE SolobacteriumSolobacterium moorei (SP279) -1.51563218564414 0.627503298363022 -2.41533740077223 0 0 TRUE DialisterDialister invisus (SP28) -1.10128371171002 0.974813013775164 -1.12973841767363 0.258586464004228 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP29) -0.683737316068557 0.898134148209275 -0.761286404076509 0.446486019486698 1 FALSE ActinomycesActinomyces israelii (SP293) 0.907354363036423 0.83746315682342 1.08345585790079 0.278606133828677 1 FALSE PeptostreptococcusPeptostreptococcus stomatis (SP296) -0.706395190015291 0.641625527691914 -1.10094620542354 0.270920070605427 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP303) -0.852416529959539 1.01938990443384 -0.836202640669635 0.40304091311058 1 FALSE ParvimonasParvimonas micra (SP31) -0.422708682770816 1.11917197281178 -0.37769770244408 0.705655174782468 1 FALSE AggregatibacterAggregatibacter sp._HMT_458 (SP32) 0.668769748500804 0.786638842444812 0.85016110623564 0.395235522181238 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP33) 0.461354064473688 0.658633752731358 0.700471335640559 0.483633000194942 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP34) -0.0493239641698075 0.671798959654436 -0.0734207212752742 0.941471328900745 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP35) -0.351026840170192 0.765525150683535 -0.458543837334098 0.646561775552672 1 FALSE ActinomycesActinomyces sp._HMT_448 (SP361) -0.132539870922733 1.49680036429565 -0.088548796542485 0.929440502588432 1 FALSE StreptococcusStreptococcus salivarius (SP374) 0.332235783829779 0.865560230486108 0.383839012154234 0.701097771252627 1 FALSE PorphyromonasPorphyromonas sp._Oral_Taxon_B94 (SP378) 0.0704298282858476 0.548559663031802 0.128390461479783 0.897839979321209 1 FALSE MycoplasmaMycoplasma salivarium (SP379) 0.128205356554439 0.450586782734721 0.284529776431367 0.776004418275652 1 FALSE TreponemaTreponema sp._HMT_231 (SP40) -0.374644503742179 0.662134125957266 -0.56581361548243 0.571520489784067 1 FALSE AlloprevotellaAlloprevotella rava (SP42) -1.28907840573032 0.583847383474674 -2.2079030277717 0 0 TRUE PeptidiphagaPeptidiphaga sp._HMT_183 (SP422) 1.20913908021396 0.7412222897508 1.63127727934419 0 0 TRUE GemellaGemella bergeri (SP450) -0.0381766075727041 0.576705317338809 -0.0661977728051285 0.947220369931165 1 FALSE RothiaRothia aeria (SP465) 1.38734956837814 0.740902081935572 1.87251406387434 0.0611355180382063 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_336 (SP48) 0.283055323395961 0.635593939752864 0.44533987140598 0.656074158143212 1 FALSE LeptotrichiaLeptotrichia wadei (SP49) -0.0899337924531892 0.902441474748726 -0.0996560940178755 0.920617358846818 1 FALSE StreptococcusStreptococcus parasanguinis_II (SP5) -1.20308544413252 1.29391865708755 -0.929799904764119 0.352474695658079 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP50) -0.516319004505497 0.58953271684482 -0.875810603470554 0.38113300468077 1 FALSE AtopobiumAtopobium rimae (SP504) -0.1258799348261 0.768736232181802 -0.163749189327049 0.869928592661673 1 FALSE FusobacteriumFusobacterium nucleatum (SP51) -0.0136763525968174 1.14283755897232 -0.011967013587754 0.990451932515482 1 FALSE StreptococcusStreptococcus mitis (SP52) -1.48367679963066 1.20817446150967 -1.22803191666271 0.219434986939567 1 FALSE StreptococcusStreptococcus constellatus (SP53) 0.0931343407579983 0.575898259251872 0.161720128966852 0.871526252575565 1 FALSE PrevotellaPrevotella maculosa (SP55) -0.45076231806962 0.687076005471726 -0.656058885013951 0.511786237222936 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP56) -0.180040640756654 1.1497663018857 -0.156588900249881 0.875568850940224 1 FALSE StreptococcusStreptococcus oralis (SP58) -0.334717400917804 1.18251772058816 -0.283054871052013 0.777134775104538 1 FALSE PrevotellaPrevotella denticola (SP60) 0.321024801175084 1.09720231552769 0.29258487393976 0.769839476909159 1 FALSE GemellaGemella sanguinis (SP61) -0.484545408712293 0.782068208296106 -0.619569244181365 0.535541420615341 1 FALSE ActinomycesActinomyces sp._HMT_175 (SP62) 0.797093537129037 0.957694433704401 0.832304656972732 0.405237002653424 1 FALSE TreponemaTreponema socranskii (SP63) -1.1167440207692 0.839703039571505 -1.32992732923661 0.183542215979427 1 FALSE StreptococcusStreptococcus gordonii (SP64) -1.1838612214562 1.19992131993248 -0.986615707038866 0.323831067161005 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -1.25341063595329 0.649738167352475 -1.92910113478578 0 0 TRUE CorynebacteriumCorynebacterium durum (SP68) 0.57511000067875 0.965234555147428 0.595824090229456 0.551292748566971 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_380 (SP7) -0.0797688774493105 0.573515899456202 -0.139087473468383 0.889381026734423 1 FALSE TreponemaTreponema sp._HMT_237 (SP70) -1.03012773426523 0.562170384347948 -1.83241195720414 0 0 TRUE PrevotellaPrevotella melaninogenica (SP79) 0.349329898403078 0.835833435446167 0.417942000868398 0.675989523095937 1 FALSE SelenomonasSelenomonas noxia (SP8) 0.174544914881893 0.934761138979846 0.186726755748943 0.851874876992115 1 FALSE FusobacteriumFusobacterium nucleatum_ss_polymorphum (SP82) -0.525972113496706 0.905214807245341 -0.581046740825299 0.561208952130572 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis (SP84) -1.95058487354228 1.15092460998029 -1.69479812719939 0.0901137228938131 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP86) -0.750002712814114 0.88512785992203 -0.847338273681929 0.396806599177263 1 FALSE StreptococcusStreptococcus infantis (SP87) -0.0352179222719772 0.831750893894995 -0.0423419109380883 0.966226135130488 1 FALSE VeillonellaVeillonella parvula (SP88) 0.426181202158209 0.889296918785471 0.479233867964203 0.631772262878858 1 FALSE PrevotellaPrevotella oulorum (SP9) 0.251888111888992 0.733132658662901 0.343577808071448 0.731163816393756 1 FALSE StreptococcusStreptococcus intermedius (SP94) 0.843837512580957 1.21159951515119 0.69646570671965 0.486137226357207 1 FALSE ActinomycesActinomyces sp._HMT_897 (SP95) -1.07261421844119 0.843335730910995 -1.27187095142112 0.203418974424811 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] bacterium_HMT_100 (SP97) 0.201102820503312 0.61190375465439 0.328651064768997 0.742419445989373 1 FALSE CapnocytophagaCapnocytophaga ochracea (SP98) 0.306563988743869 0.60777240920646 0.504405899478285 0.61397617322281 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP99) -0.130862156824932 0.95088226667108 -0.137621829128294 0.890539302538023 1 FALSE ActinomycesActinomyces viscosus_nov_95.849% (SPN129) 0.173624315371717 0.671948379544768 0.258389365399383 0.796106423188788 1 FALSE ActinomycesActinomyces sp._HMT_175_nov_97.633% (SPN13) 0.812008746477814 1.09928814791269 0.738667789714318 0.46010874932342 1 FALSE CapnocytophagaCapnocytophaga gingivalis_nov_97.665% (SPN399) 0.340468754026344 0.654398215838706 0.520277631854457 0.602870083818619 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nov_97.416% (SPN547) -0.699674731148618 0.668576429218517 -1.04651420626128 0.295323689436473 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP26) 0.391204520143644 1.22959659560666 0.318156801622105 0.750365998812289 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP3) -0.323615982800391 1.00060200703781 -0.323421280913105 0.746376214998167 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii (SPP59) 0.244692542278163 0.526665138473471 0.464607441053341 0.642212602592606 1 FALSE Eubacterium_[XIVa][G-1]_LachnoanaerobaculumEubacterium_[XIVa][G-1]_Lachnoanaerobaculum saburreum (SPP6) 0.0742475454771326 0.868638632253898 0.0854757579506669 0.931883167279899 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP60) 0.223979316797812 1.04368315368771 0.214604706424944 0.830075524233505 1 FALSE