GroupSaliva Periodontitis...1 GroupSaliva Parkinson + Periodontitis...2 GroupSaliva Periodontitis...3 GroupSaliva Parkinson + Periodontitis...4 GroupSaliva Periodontitis...5 GroupSaliva Parkinson + Periodontitis...6 GroupSaliva Periodontitis...7 GroupSaliva Parkinson + Periodontitis...8 GroupSaliva Periodontitis...9 GroupSaliva Parkinson + Periodontitis...10 GroupSaliva Periodontitis...11 GroupSaliva Parkinson + Periodontitis...12 1 Coefficients Coefficients Standard Errors Standard Errors Test Statistics W Test Statistics W p Values p Values Adjusted p Values Adjusted p Values Differential Abundance Differential Abundance Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP104) 3.32437908250455 2.02367979108531 0.633547378561962 0.757601091926417 5.24724621235161 2.67116799678777 1.54389509907872e-07 0.00755878057898854 1.11160447133668e-05 0.423291712423358 TRUE FALSE SchaaliaSchaalia sp._HMT_180 (SP106) 0.110199381146681 -1.17631273407494 0.668920325760843 0.701842948394375 0.164742162710242 -1.67603412809949 0.869146929314448 0.0937315079658585 1 1 FALSE FALSE HaemophilusHaemophilus parainfluenzae (SP108) -1.32767335569075 -1.70185791775331 0.74950695438901 0.820725151777284 -1.77139564605249 -2.07360273298305 0.0764949321183295 0.038116221182502 1 1 FALSE FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP109) 1.29390341052244 -0.306893274113698 0.632448967312099 0.655508542469335 2.04586216026491 -0.468175857720504 0.0407699341873953 0.639658835312464 1 1 FALSE FALSE RothiaRothia dentocariosa (SP116) -2.79097566493612 -3.40854712908614 0.831038668683352 0.872371172331542 -3.35841853106304 -3.90722118886195 0.000783898245631765 9.33636786013928e-05 0.0525211824573282 0.0064420938234961 FALSE TRUE AbiotrophiaAbiotrophia defectiva (SP118) 0.0838570724145661 -0.494809215199791 0.791813683132915 0.905118502282552 0.105905055950504 -0.546678930937737 0.915657682562453 0.584599331479416 1 1 FALSE FALSE FusobacteriumFusobacterium periodonticum (SP124) -1.10157120695377 -2.3371482857325 0.626292538682903 0.635085430948069 -1.75887646573338 -3.68005337839912 0.0785984933004922 0.000233185136960173 1 0.0158565893132918 FALSE TRUE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP132) 2.33604139442894 2.34632495635922 0.76392463671503 0.713090879375003 3.05794744946858 3.29035894894026 0.00222858653784676 0.00100059652771373 0.142629538422193 0.0630375812459651 FALSE FALSE SchaaliaSchaalia sp._HMT_172 (SP133) 0.808431220448968 -1.1574667651475 0.705446807899559 0.596965768044108 1.14598466021278 -1.93891647914722 0.251801499231775 0.0525115090058665 1 1 FALSE FALSE NeisseriaNeisseria elongata (SP136) 0.990193777840117 -0.318395786274139 0.558026304370415 0.621012483409369 1.7744571717946 -0.512704325243417 0.0759875602829644 0.608158163687956 1 1 FALSE FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP137) 2.58140379693611 1.83435019152912 0.628793631265508 0.64297164205845 4.10532751698007 2.85292549708182 4.03742442449292e-05 0.00433187762338172 0.00282619709714504 0.255580779779521 TRUE FALSE PeptostreptococcusPeptostreptococcus stomatis (SP155) 0.0924243926436278 -1.63932590512994 0.714024024157933 0.798750196802571 0.129441572715465 -2.05236369479748 0.897008254089792 0.0401343300803052 1 1 FALSE FALSE TannerellaTannerella forsythia (SP158) 2.17926022352766 1.4958834705679 0.537837039872868 0.568506719337986 4.05189687947633 2.63125029077901 0 0 0 0 TRUE TRUE PrevotellaPrevotella salivae (SP163) -0.635694726587867 -0.569222621064712 0.535542978800356 0.730565166975436 -1.18700972984812 -0.77915379324929 0 0.435889125332707 0 1 TRUE FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP171) 1.27633430993511 0.57961085703035 0.826140214330241 0.912506078242902 1.54493666788736 0.63518574927899 0.122361583036404 0.525307276443731 1 1 FALSE FALSE BergeyellaBergeyella sp._HMT_322 (SP179) -1.24722875500025 -2.51269018062463 0.783066364662168 0.787682351185604 -1.5927497480221 -3.18997902751354 0.111216342456042 0.00142283118786438 1 0.0856759233979633 FALSE FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP182) 1.21806115689452 1.51357493525986 0.476586029803728 0.532260856786193 2.55580541753638 2.84367132386715 0 0 0 0 TRUE TRUE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_sulci (SP186) -0.346532878947067 -0.453278992777217 0.814857739156365 0.815608242149593 -0.425267948373219 -0.555755777531831 0.670641355857094 0.578377820421435 1 1 FALSE FALSE MycoplasmaMycoplasma faucium (SP188) 2.93567933295018 2.27446324405471 0.503456869560127 0.561272661747825 5.8310443464901 4.05233213563608 0 0 0 0 TRUE TRUE OribacteriumOribacterium sinus (SP206) -1.42796949638446 -2.35862847172561 0.688403518891491 0.738520773185471 -2.07432044897717 -3.19371987541001 0.0380495598996624 0.00140452333439284 1 0.0856759233979633 FALSE FALSE PrevotellaPrevotella melaninogenica (SP222) -2.09929309868698 -1.75805900675793 0.693004715183332 0.837613964737986 -3.02926235953766 -2.09888932225224 0.00245151686246009 0.0358266583394045 0.154445562334985 1 FALSE FALSE Ruminococcaceae_[G-2]Ruminococcaceae_[G-2] bacterium_HMT_085 (SP223) 0.669698235530034 1.11868941923293 0.689460431467643 0.776462049720241 0.971336722115378 1.44075221659061 0.331380627875637 0.149654697242463 1 1 FALSE FALSE Erysipelotrichaceae_[G-1]Erysipelotrichaceae_[G-1] bacterium_HMT_905 (SP227) 1.77657345858267 0.766680392375222 0.568748703801411 0.600639300707712 3.12365276036392 1.2764406049885 0.00178621117384495 0.201799810188737 0.116422872740196 1 FALSE FALSE GemellaGemella sanguinis (SP23) -1.75237872902149 -3.89506589328431 0.840631375438581 0.811080858391357 -2.0845982915011 -4.80231514896002 0.0371057797112838 1.56841586347002e-06 1 0.000112925942169841 FALSE TRUE Absconditabacteria_(SR1)_[G-1]Absconditabacteria_(SR1)_[G-1] bacterium_HMT_345 (SP234) -0.906811192917031 -0.562412940784961 0.752271863776425 0.82117890873264 -1.20543015973616 -0.684884785524943 0.228037284334646 0.493416627487894 1 1 FALSE FALSE CampylobacterCampylobacter concisus (SP236) -0.228138173156278 -0.00474340426320718 0.623381425541681 0.692442548737187 -0.365968833540459 -0.0068502495576821 0.71438833193655 0.994534334387209 1 1 FALSE FALSE ActinomycesActinomyces graevenitzii (SP241) -0.892212969130658 -1.96835569859633 0.70926942648966 0.761992988961287 -1.2579323678823 -2.58316772872083 0.208416216567367 0.00978977159540405 1 0.528647666151819 FALSE FALSE PorphyromonasPorphyromonas endodontalis (SP248) 1.64473209253839 -0.129682524487354 0.780998509019634 0.84439451999842 2.10593499672999 -0.153580490417674 0.0352099991922107 0.877940520806979 1 1 FALSE FALSE RothiaRothia mucilaginosa (SP25) -0.166735176998113 -1.69435409708004 0.676718596448556 0.712517628381453 -0.246387756850699 -2.37798200295607 0.805382082787199 0.0174076755064552 1 0.916584708802301 FALSE FALSE PorphyromonasPorphyromonas sp._HMT_285 (SP252) 0.786172850757677 -0.126185335960858 0.636176845849705 0.633386538366204 1.23577721491519 -0.199223267811072 0.216541386673363 0.842088099142679 1 1 FALSE FALSE CapnocytophagaCapnocytophaga gingivalis (SP268) -0.976745785988405 -2.46674281435716 0.720000722255847 0.698854484336527 -1.35659000858797 -3.5296944780987 0.174911518209205 0.000416039805493653 1 0.0274586271625811 FALSE TRUE GemellaGemella haemolysans (SP275) 0.318934894929053 0.346689941406484 0.929577851815858 0.869531381741244 0.343096486546058 0.398708946780316 0.731525874219693 0.69010767479384 1 1 FALSE FALSE CorynebacteriumCorynebacterium durum (SP280) -0.13406317967694 -1.30931116267115 0.604372639835743 0.605996821256966 -0.221822052886735 -2.16059080962728 0.82445241137467 0.0307269619750511 1 1 FALSE FALSE StomatobaculumStomatobaculum sp._HMT_097 (SP283) -0.517696037217422 -2.88953975464393 0.655242210307587 0.54328571516007 -0.79008346695858 -5.31863745725869 0.42947902459966 0 1 0 FALSE TRUE PrevotellaPrevotella pallens (SP30) -1.24046857444134 -1.11457784407598 0.586502924530377 0.779861632786543 -2.11502538616427 -1.42919948516182 0.0344277837146435 0.152946905647679 1 1 FALSE FALSE CapnocytophagaCapnocytophaga leadbetteri (SP323) 0.791024529360225 -0.404234879166815 0.682647285691985 0.724577912213937 1.15876023524854 -0.557890148668321 0.246553930365942 0.576919398954311 1 1 FALSE FALSE Peptostreptococcaceae_[XI][G-4]Peptostreptococcaceae_[XI][G-4] bacterium_HMT_369 (SP325) 2.42690905368732 0.722374618197278 0.56088516677351 0.653470595734644 4.32692678903974 1.10544318736357 1.51204190357627e-05 0.268967599013695 0.00107354975153915 1 TRUE FALSE GranulicatellaGranulicatella elegans (SP355) -0.0287010732427349 -0.584653283643988 0.770960979744328 0.813855465841559 -0.0372276600201647 -0.71837483212014 0.97030348438706 0.472526200729784 1 1 FALSE FALSE TM7_[G]TM7_[G] sp._Oral_Taxon_A56 (SP384) -0.405352933667504 -1.50714396592019 0.642530648542856 0.633148471681335 -0.630869413913207 -2.3803958049807 0.528125912133451 0.0172940511094774 1 0.916584708802301 FALSE FALSE CorynebacteriumCorynebacterium argentoratense (SP392) 1.00904434984197 0.220182393455679 0.518898767633149 0.61190380849288 1.94458806376535 0.359831709493668 0 0 0 0 TRUE TRUE VeillonellaVeillonella atypica (SP426) 0.195680226203373 -0.192278864827629 0.549248401577698 0.69838051992114 0.356269086339236 -0.275321059713035 0.721639057997544 0.783069586140416 1 1 FALSE FALSE PorphyromonasPorphyromonas pasteri (SP43) -1.49688167588842 -2.64561112588252 0.874136990004534 0.804245495415568 -1.71241086123201 -3.28955666020298 0.0868209788833527 0.00100345351106966 1 0.0630375812459651 FALSE FALSE SelenomonasSelenomonas noxia (SP435) 0.580687257821669 -0.0130031571422023 0.476213056731849 0.622351438088361 1.2193854192214 -0.0208935921834508 0.22269794140874 0.983330538206508 1 1 FALSE FALSE NeisseriaNeisseria subflava (SP56) -0.155747814125757 0.34772762755479 0.758105166078437 0.8960901235079 -0.205443546746182 0.388049838328259 0.837225600411702 0.697979152057417 1 1 FALSE FALSE StreptococcusStreptococcus anginosus (SP59) 0.0257582862164595 0.431836869098751 0.722214687702453 0.854156194615416 0.0356656914558233 0.505571313327752 0.971548927389279 0.613157624110847 1 1 FALSE FALSE Ruminococcaceae_[G-1]Ruminococcaceae_[G-1] bacterium_HMT_075 (SP60) 1.61928254372052 0.489361062645991 0.659172108708663 0.783244079488531 2.4565398358446 0.624787439141002 0.0140282248181839 0.53211057571837 0.827665264272849 1 FALSE FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP66) 1.46533907526058 1.75919292170346 0.579965335931111 0.628333696956025 2.52659768520137 2.79977491295773 0.0115173353728505 0.00511382511511535 0.691040122371032 0.291488031561575 FALSE FALSE ParvimonasParvimonas micra (SP68) 1.45871984652154 1.37904459941915 0.553792394383095 0.674851973963396 2.63405539930989 2.04347716628883 0.00843717204479463 0.041005225473708 0.523104666777267 1 FALSE FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_352 (SP70) -0.325231710192033 -0.78705483619818 0.76973959233398 0.690020620540902 -0.422521737781313 -1.14062509549528 0.672644237500788 0.254025969388541 1 1 FALSE FALSE SolobacteriumSolobacterium moorei (SP81) 0.0811887408415427 0.517548114555621 0.724000267800279 0.542337426076223 0.11213910332964 0.954291718902841 0.91071311297268 0.33993599864733 1 1 FALSE FALSE Gracilibacteria_(GN02)_[G-2]Gracilibacteria_(GN02)_[G-2] bacterium_HMT_873 (SP89) 1.73236520375175 0.494317084386779 0.553942808048249 0.655633441688802 3.1273358523338 0.753953433359807 0.001763982920306 0.450877183916975 0.116422872740196 1 FALSE FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346_nov_97.968% (SPN45) 1.22842185052662 0.995412600201997 0.606303853296858 0.771822966429379 2.02608286892276 1.28969030917413 0.0427562933039253 0.19715820562553 1 1 FALSE FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351_nov_97.072% (SPN467) -0.00475085164035766 -0.388636837987489 0.522234844703653 0.652146046249894 -0.00909715559683417 -0.595935282015907 0.992741620117327 0.551218462094925 1 1 FALSE FALSE NeisseriaNeisseria flavescens_flavescens|subflava (SPP109) -0.353026552227749 0.20394039190658 0.95210094220419 1.11295820064895 -0.37078689514839 0.183241735213115 0.710796262873905 0.854608348756717 1 1 FALSE FALSE StreptococcusStreptococcus cristatus_gwangjuense_infantis_infantis_clade_431_ ...(20 species) (SPP11) 0.26186844976703 -1.60028671515396 0.415617947193906 0.4842516825556 0.630070119770009 -3.30465907048288 0.528648708266475 0.000950919964612931 1 0.0608588777352276 FALSE FALSE NeisseriaNeisseria flavescens|subflava_perflava (SPP111) 0.68167182462277 -0.0246971127384636 0.773130775061289 0.9711241387105 0.881703130455169 -0.02543146828917 0.377937367695111 0.979710811154968 1 1 FALSE FALSE StreptococcusStreptococcus sanguinis_sp._HMT_074 (SPP113) -0.997359190569387 -2.89584558946975 0.664651095266756 0.622666068290547 -1.50057556163223 -4.65072008407322 0.133465376168071 3.30778037500833e-06 1 0.000234852406625591 FALSE TRUE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP118) 0.268769993249547 -0.276999868211021 0.831346151591357 0.849833064472828 0.323294926830501 -0.325946212016181 0.746471895693769 0.744465051116586 1 1 FALSE FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP134) 0.0522521429217144 -1.47696029648378 0.289440173821164 0.403802072525738 0.180528301347688 -3.65763426434528 0.85673783811394 0.000254553923077145 1 0.0170551128461687 FALSE TRUE Actinomyces_SchaaliaActinomyces_Schaalia odontolytica_odontolyticus (SPP135) 1.43198238821164 -0.259014010483135 0.66515663747818 0.587251078158289 2.15284988155683 -0.441061787907556 0.0313304784291588 0.659168266197718 1 1 FALSE FALSE StreptococcusStreptococcus salivarius_sp._str._ACS2_sp._str._C150_vestibulari ...(4 species) (SPP17) -1.24757585422966 -0.729008849295691 0.866538343773677 0.959378731475251 -1.43972377355698 -0.759875975335291 0.149945564578471 0.447328723468894 1 1 FALSE FALSE ParvimonasParvimonas sp._HMT_110_sp._HMT_393_sp._Oral_Taxon_110 (SPP18) 0.63775987582703 0.188204496996597 0.832967948223805 0.910123339821679 0.765647558452842 0.206790100596115 0.44388603835338 0.836173787637161 1 1 FALSE FALSE GemellaGemella morbillorum_moribillum (SPP27) 2.75041929450313 2.15926598954379 0.689225697851981 0.645928068964524 3.9905930714351 3.34288923688556 6.59082787075993e-05 0.000829109866274636 0.00448176295211675 0.0538921413078514 TRUE FALSE NeisseriaNeisseria flava_macacae_mucosa_sicca_sp._TM101 (SPP39) -0.0277509570375266 1.32731660119375 0.403107401245362 0.738207279470098 -0.0688425887289408 1.79802697441094 0 0.0721727332550173 0 1 TRUE FALSE Actinomyces_SchaaliaActinomyces_Schaalia odontolyticus_sp._HMT_180 (SPP5) 0.340784764185348 -0.560113420998861 0.936571578918041 1.02136749526893 0.363864088828143 -0.548395581016002 0.715959502083852 0.58342031004583 1 1 FALSE FALSE SelenomonasSelenomonas sp._HMT_136_sp._Oral_Taxon_149 (SPP56) 0.182913792692261 -0.774105404662792 0.796907753029349 0.804703422538345 0.229529443021398 -0.961976031145693 0.818457439164406 0.336061644164097 1 1 FALSE FALSE VeillonellaVeillonella rogosae_sp._str._NVG100cf (SPP60) -0.245682704959925 -1.59845468390979 0.665668651622415 0.708432731510372 -0.369076573398987 -2.25632528370323 0.712070649911905 0.024050267074283 1 1 FALSE FALSE VeillonellaVeillonella dispar_parvula (SPP70) -0.0990250545386121 -1.49606776132305 0.766361527853744 0.779713370330399 -0.1292145429272 -1.91874067862797 0.897187889088408 0.0550171606418462 1 1 FALSE FALSE OribacteriumOribacterium parvum_sp._str._ACB1 (SPP79) 0.145501643506773 -0.735498431118295 0.589835451547516 0.674933016048384 0.246681753572169 -1.0897354457847 0.805154528788528 0.275829697404303 1 1 FALSE FALSE MogibacteriumMogibacterium diversum_neglectum_vescum (SPP8) 1.36161560676597 0.517896987519658 0.557997910780397 0.635312995247493 2.44018047462161 0.815183998114042 0.0146799260214447 0.414966996050398 0.85143570924379 1 FALSE FALSE ActinomycesActinomyces sp._HMT_169_sp._str._ChDCB197 (SPP87) -0.143928468659606 -1.17886840355335 0.698741165334018 0.72387607117573 -0.20598252371578 -1.62855003845979 0.836804562638887 0.103408308175432 1 1 FALSE FALSE StreptococcusStreptococcus parasanguinis_parasanguinis_I_parasanguinis_clade_ ...(4 species) (SPP95) 0.635217432187787 -0.204603530571813 0.627653329648977 0.737021760019068 1.01205140191488 -0.277608534334888 0.311513477038539 0.781312880117038 1 1 FALSE FALSE MobiluncusMobiluncus multispecies_sppn34_2_nov_97.817% (SPPN34) -0.588064637107994 -1.49771472348412 0.65979081762386 0.740761181866843 -0.89128951388839 -2.02185908245033 0.372773872766014 0.0431909119482911 1 1 FALSE FALSE