GroupSaliva Periodontitis...1 GroupSaliva Periodontitis...2 GroupSaliva Periodontitis...3 GroupSaliva Periodontitis...4 GroupSaliva Periodontitis...5 GroupSaliva Periodontitis...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP104) 3.35870693094605 0.625213820388157 5.37209322861872 7.7827850028422e-08 8.483235653098e-06 TRUE SchaaliaSchaalia sp._HMT_180 (SP106) 0.144527229588192 0.653139511678114 0.22128079377231 0.824873803678522 1 FALSE HaemophilusHaemophilus parainfluenzae (SP108) -1.29334550724924 0.748530872515306 -1.7278452429132 0.0840159735790623 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP109) 1.32823125896395 0.619356170638565 2.14453544169024 0.0319900087941171 1 FALSE RothiaRothia dentocariosa (SP116) -2.75664781649461 0.821065530357847 -3.35740292896375 0.000786783646300995 0.0778915809837985 FALSE AbiotrophiaAbiotrophia defectiva (SP118) 0.118184920856079 0.792669197882606 0.14909740554039 0.881476773087978 1 FALSE FusobacteriumFusobacterium periodonticum (SP124) -1.06724335851226 0.619189945121184 -1.72361222419945 0.0847778702581594 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP132) 2.37036924287044 0.759084555528779 3.12266825297116 0.00179219634318621 0.17025865260269 FALSE SchaaliaSchaalia sp._HMT_172 (SP133) 0.842759068890478 0.700084869325816 1.20379557653068 0.2286685998407 1 FALSE NeisseriaNeisseria elongata (SP136) 1.02452162628163 0.537877533269698 1.9047488748111 0.0568127224770964 1 FALSE Saccharibacteria_(TM7)_[G-5]Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP137) 2.61573164537762 0.622701519210292 4.20061869881878 2.66186567050277e-05 0.00279495895402791 TRUE PeptostreptococcusPeptostreptococcus stomatis (SP155) 0.126752241085139 0.699384330001391 0.181234030629321 0.856183884286471 1 FALSE TannerellaTannerella forsythia (SP158) 2.21358807196917 0.516699595255467 4.28409097335314 0 0 TRUE LautropiaLautropia mirabilis (SP159) -0.117035702506103 0.486415212712796 -0.240608639383174 0.809858453618247 1 FALSE Saccharibacteria_(TM7)_[G-3]Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP171) 1.31066215837662 0.821194085229251 1.59604432368838 0.110478897795859 1 FALSE TannerellaTannerella sp._HMT_286 (SP174) -0.74403154065589 0.537322958141327 -1.38470081983766 0.166143968306571 1 FALSE TreponemaTreponema denticola (SP178) 1.42562941799153 0.41265568515683 3.45476742299024 0 0 TRUE BergeyellaBergeyella sp._HMT_322 (SP179) -1.21290090655874 0.761747100780995 -1.59226192697706 0.111325863845638 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_155 (SP182) 1.25238900533603 0.468546637339199 2.67292283314239 0 0 TRUE StreptococcusStreptococcus lactarius (SP184) 1.08108148986218 0.53875753844214 2.00661969944441 0.0447901721237784 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_sulci (SP186) -0.312205030505555 0.817384464921643 -0.381956158826047 0.702493883761479 1 FALSE MycoplasmaMycoplasma faucium (SP188) 2.97000718139169 0.482819235207026 6.15138537328198 0 0 TRUE Clostridiales_[G]Clostridiales_[G] sp._Oral_Taxon_G74 (SP205) 1.28542396589406 0.441223657785318 2.91331605459719 0 0 TRUE OribacteriumOribacterium sinus (SP206) -1.39364164794295 0.677179875904129 -2.05800806777113 0.0395893589521117 1 FALSE Bacteroidaceae_[G-1]Bacteroidaceae_[G-1] bacterium_HMT_272 (SP219) 1.41975598562778 0.382375165475154 3.71299214441278 0 0 TRUE PrevotellaPrevotella melaninogenica (SP222) -2.06496525024547 0.695889457671451 -2.96737538912452 0.00300354003570117 0.28233276335591 FALSE Ruminococcaceae_[G-2]Ruminococcaceae_[G-2] bacterium_HMT_085 (SP223) 0.704026083971544 0.6912264759013 1.01851724220134 0.308432211036411 1 FALSE Erysipelotrichaceae_[G-1]Erysipelotrichaceae_[G-1] bacterium_HMT_905 (SP227) 1.81090130702418 0.549571837620431 3.29511300081375 0.000983821096722336 0.096414467478789 FALSE GemellaGemella sanguinis (SP23) -1.71805088057998 0.820946320842199 -2.0927688412288 0.0363697945537321 1 FALSE Absconditabacteria_(SR1)_[G-1]Absconditabacteria_(SR1)_[G-1] bacterium_HMT_345 (SP234) -0.872483344475519 0.737918649340952 -1.18235708672595 0.237064043059977 1 FALSE CampylobacterCampylobacter concisus (SP236) -0.193810324714766 0.615186246982146 -0.315043331455346 0.752728754013566 1 FALSE ActinomycesActinomyces graevenitzii (SP241) -0.857885120689146 0.701690943945886 -1.22259682569782 0.221482012652107 1 FALSE PorphyromonasPorphyromonas endodontalis (SP248) 1.6790599409799 0.768072973405552 2.18606825017567 0.0288106124323365 1 FALSE RothiaRothia mucilaginosa (SP25) -0.132407328556602 0.661693833932277 -0.200103615549414 0.841399545754433 1 FALSE PorphyromonasPorphyromonas sp._HMT_285 (SP252) 0.820500699199187 0.615924468715032 1.33214499646515 0.18281254676793 1 FALSE SlackiaSlackia exigua (SP255) 0.835537405869631 0.453162832910019 1.84379067564779 0.0652136521357798 1 FALSE Saccharibacteria_(TM7)_[G-4]Saccharibacteria_(TM7)_[G-4] bacterium_HMT_355 (SP261) 1.98941589010518 0.510759298765921 3.89501648802466 0 0 TRUE Bacteroidetes_[G-3]Bacteroidetes_[G-3] bacterium_HMT_280 (SP262) 1.13157453357114 0.390697862367136 2.89629056764023 0 0 TRUE CapnocytophagaCapnocytophaga gingivalis (SP268) -0.942417937546893 0.692718598830272 -1.3604628764671 0.17368349293031 1 FALSE Mollicutes_[G-2]Mollicutes_[G-2] bacterium_HMT_906 (SP274) 1.09985943861207 0.396266158546496 2.77555732401263 0 0 TRUE GemellaGemella haemolysans (SP275) 0.353262743370564 0.915038204594156 0.386063381394272 0.699449728871924 1 FALSE TreponemaTreponema socranskii (SP279) 1.19880753085519 0.453922409415909 2.64099658000532 0.0082662553795355 0.694365451880982 FALSE CorynebacteriumCorynebacterium durum (SP280) -0.0997353312354288 0.604587891865325 -0.164964155877679 0.868972194938799 1 FALSE StomatobaculumStomatobaculum sp._HMT_097 (SP283) -0.48336818877591 0.643358429694916 -0.75132020731449 0.452459970823472 1 FALSE PrevotellaPrevotella pallens (SP30) -1.20614072599982 0.577262982747262 -2.08941290546582 0.0366705705039587 1 FALSE AlloprevotellaAlloprevotella tannerae (SP313) -0.426555580145886 0.380737085500189 -1.12034155954496 0 0 TRUE CatonellaCatonella morbi (SP318) -0.263078512160943 0.514578280673642 -0.511250711585695 0.609175513198852 1 FALSE CapnocytophagaCapnocytophaga leadbetteri (SP323) 0.825352377801736 0.666307072983626 1.23869670796969 0.215457838311116 1 FALSE Peptostreptococcaceae_[XI][G-4]Peptostreptococcaceae_[XI][G-4] bacterium_HMT_369 (SP325) 2.46123690212883 0.545153955309792 4.51475565417148 6.33898106044323e-06 0.000684609954527868 TRUE Peptostreptococcaceae_[XI][G-5]Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP327) 1.15590476193267 0.521240177357682 2.21760488186519 0.0265817847438676 1 FALSE Absconditabacteria_(SR1)_[G-1]Absconditabacteria_(SR1)_[G-1] bacterium_HMT_874 (SP329) 1.32557736720669 0.483764053055251 2.74013201029489 0 0 TRUE PrevotellaPrevotella shahii (SP343) -0.136268229320385 0.398530087821228 -0.34192708024974 0.732405769495946 1 FALSE OttowiaOttowia sp._HMT_894 (SP352) 1.12147822832434 0.421842119577961 2.65852596570096 0 0 TRUE GranulicatellaGranulicatella elegans (SP355) 0.00562677519877669 0.752536178783691 0.00747708264055973 0.994034206789335 1 FALSE CardiobacteriumCardiobacterium hominis (SP356) 1.73342528500498 0.498697316351083 3.47590658335256 0.000509129597504158 0.05142208934792 FALSE FilifactorFilifactor alocis (SP372) 1.24596449451213 0.489135553710675 2.5472785305832 0.0108566741125459 0.901103951341307 FALSE SelenomonasSelenomonas sp._HMT_478 (SP373) -0.26830079858733 0.502210201250088 -0.534240041161018 0.593175469453718 1 FALSE TM7_[G]TM7_[G] sp._Oral_Taxon_A56 (SP384) -0.371025085225993 0.635109848347421 -0.584190413975494 0.559092210200142 1 FALSE Lachnospiraceae_[G-8]Lachnospiraceae_[G-8] bacterium_HMT_500 (SP39) 2.02408847689864 0.477251430045517 4.24113653615578 0 0 TRUE CapnocytophagaCapnocytophaga sputigena (SP409) -0.797333778676202 0.646265632160326 -1.23375550083158 0.217294025708798 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP414) 0.0966658425845733 0.589084862350289 0.164094935658171 0.869656408533156 1 FALSE VeillonellaVeillonella atypica (SP426) 0.230008074644884 0.54345009762134 0.423236789636473 0.672122507476737 1 FALSE PorphyromonasPorphyromonas pasteri (SP43) -1.46255382744691 0.852032931248952 -1.71654612610222 0.0860621332024976 1 FALSE SelenomonasSelenomonas noxia (SP435) 0.615015106263179 0.46974455131361 1.30925436930206 0.19044820083399 1 FALSE LeptotrichiaLeptotrichia sp._HMT_417 (SP488) -0.525849462687316 0.458511704001227 -1.14686159175101 0.251438828774309 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP529) -0.512008062195747 0.443145904152353 -1.15539387230739 0 0 TRUE StreptococcusStreptococcus sanguinis (SP55) -0.813324315640423 0.55418734229253 -1.46759814519745 0.142213412136862 1 FALSE NeisseriaNeisseria subflava (SP56) -0.121419965684247 0.736788345692783 -0.164796262582138 0.869104345850042 1 FALSE StreptococcusStreptococcus anginosus (SP59) 0.0600861346579705 0.703085062376942 0.0854606901401594 0.931895145822739 1 FALSE Ruminococcaceae_[G-1]Ruminococcaceae_[G-1] bacterium_HMT_075 (SP60) 1.65361039216202 0.660995859102564 2.5016955392234 0.0123600166383463 1 FALSE StreptococcusStreptococcus sinensis (SP63) 0.694983519960314 0.590135446627952 1.17766781157015 0.238929064103358 1 FALSE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP66) 1.49966692370209 0.564474177328579 2.65675027119821 0.00788978640940242 0.674956402622276 FALSE ParvimonasParvimonas micra (SP68) 1.49304769496305 0.532386245294148 2.8044445328187 0.00504033592146965 0.453630232932268 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_352 (SP70) -0.290903861750522 0.775841987050507 -0.374952460173549 0.707695822822948 1 FALSE SchaaliaSchaalia odontolytica (SP75) 0.320569059064054 0.535979558988835 0.598099411979127 0.549773602599871 1 FALSE SolobacteriumSolobacterium moorei (SP81) 0.115516589283055 0.727269284696365 0.158836062121451 0.873798036000759 1 FALSE Gracilibacteria_(GN02)_[G-1]Gracilibacteria_(GN02)_[G-1] bacterium_HMT_872 (SP82) 1.27326141504017 0.403276065531826 3.15729477612573 0 0 TRUE Gracilibacteria_(GN02)_[G-2]Gracilibacteria_(GN02)_[G-2] bacterium_HMT_873 (SP89) 1.76669305219326 0.557067033348502 3.17141914066204 0.00151696093063636 0.147145210271727 FALSE TreponemaTreponema denticola_nov_90.000% (SPN15) 0.683654726573788 0.328673170440241 2.08004421431195 0.0375214776244865 1 FALSE Saccharibacteria_(TM7)_[G-1]Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346_nov_97.968% (SPN45) 1.26274969896813 0.593153380481523 2.12887549918881 0.0332645623491802 1 FALSE TreponemaTreponema sp._HMT_927_nov_95.484% (SPN622) 1.33298536522746 0.453748089255134 2.93772116465695 0 0 TRUE Firmicutes_[G]Firmicutes_[G] sp._Oral_Taxon_A55_nov_88.651% (SPN630) 0.972364801026623 0.456528535251248 2.12991023768424 0.0331790247681734 1 FALSE StreptococcusStreptococcus species5_nov_87.234% (SPN634) 0.22897600881131 0.552767157599419 0.414235914097568 0.678701342306459 1 FALSE NeisseriaNeisseria flavescens_flavescens|subflava (SPP109) -0.318698703786237 0.940477394800553 -0.338869073885421 0.734708362926353 1 FALSE StreptococcusStreptococcus cristatus_gwangjuense_infantis_infantis_clade_431_infantis_clade_638_mitis_oralis_oralis_subsp._dentisani_clade_058_oralis_subsp._dentisani_clade_398_oralis_subsp._oralis_oralis_subsp._tigurinus_clade_070_oralis_subsp._tigurinus_clade_071_periodonticum_pneumoniae_sp._HMT_061_sp._HMT_064_sp._HMT_423_sp._Oral_Taxon_71_sp._str._C300_sp._str._M334 (SPP11) 0.29619629820854 0.38522774415783 0.768886204850257 0.441960867540634 1 FALSE NeisseriaNeisseria flavescens|subflava_perflava (SPP111) 0.715999673064281 0.759425096006141 0.942818030151707 0.345773987726884 1 FALSE StreptococcusStreptococcus sanguinis_sp._HMT_074 (SPP113) -0.963031342127875 0.641878392180888 -1.50033301301173 0.133528161991313 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP118) 0.303097841691058 0.836423155095031 0.362373805465275 0.717072711445633 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP134) 0.0865799913632248 0.258308723149492 0.335180284690262 0.737489093252302 1 FALSE Actinomyces_SchaaliaActinomyces_Schaalia odontolytica_odontolyticus (SPP135) 1.46631023665315 0.644331958440176 2.27570620616561 0.0228635996619828 1 FALSE StreptococcusStreptococcus salivarius_sp._str._ACS2_sp._str._C150_vestibularis (SPP17) -1.21324800578814 0.868332204945185 -1.39721640966286 0.162348503555351 1 FALSE ParvimonasParvimonas sp._HMT_110_sp._HMT_393_sp._Oral_Taxon_110 (SPP18) 0.67208772426854 0.834366165074658 0.805506925377784 0.420527211604649 1 FALSE StreptococcusStreptococcus gordonii_sp._str._2136FAA (SPP2) 0.556520624696223 0.540326834123963 1.02997036154703 0.303023918894758 1 FALSE StreptococcusStreptococcus sanguinis_sp._Oral_Taxon_B66 (SPP25) -0.443555373103794 0.477931491525428 -0.928073125476802 0.353369638967228 1 FALSE GemellaGemella morbillorum_moribillum (SPP27) 2.78474714294464 0.673801745483259 4.13288799207159 3.58233327708541e-05 0.00372562660816882 TRUE Actinomyces_SchaaliaActinomyces_Schaalia odontolyticus_sp._HMT_180 (SPP4) -0.432271075720516 0.624073743137179 -0.692660251250946 0.488522789359136 1 FALSE Actinomyces_SchaaliaActinomyces_Schaalia odontolyticus_sp._HMT_180 (SPP5) 0.375112612626857 0.947942790149979 0.39571229036671 0.6923172876739 1 FALSE CampylobacterCampylobacter rectus_showae (SPP55) 0.879728815116004 0.502097641455938 1.75210704548431 0.0797554030232307 1 FALSE SelenomonasSelenomonas sp._HMT_136_sp._Oral_Taxon_149 (SPP56) 0.217241641133772 0.790055848499849 0.2749699803454 0.783339301837518 1 FALSE VeillonellaVeillonella rogosae_sp._str._NVG100cf (SPP60) -0.211354856518413 0.649567277656454 -0.325377930490821 0.744895056480216 1 FALSE StreptococcusStreptococcus cristatus_cristatus_clade_578 (SPP7) 0.178790236885467 0.485303844529757 0.368408861583838 0.712568390832287 1 FALSE VeillonellaVeillonella dispar_parvula (SPP70) -0.0646972060971008 0.753874306291129 -0.0858196194739607 0.931609809931715 1 FALSE VeillonellaVeillonella parvula_tobetsuensis (SPP71) 0.87667657981098 0.585487954704733 1.49734349403157 0.134303903093777 1 FALSE LachnoanaerobaculumLachnoanaerobaculum gingivalis_umeaense (SPP76) -0.300600799915462 0.613214009568859 -0.490205369128487 0.623988581871257 1 FALSE OribacteriumOribacterium parvum_sp._str._ACB1 (SPP79) 0.179829491948284 0.57196900509777 0.31440426027551 0.75321402086021 1 FALSE MogibacteriumMogibacterium diversum_neglectum_vescum (SPP8) 1.39594345520748 0.558985523401633 2.49728015622417 0.0125150039135809 1 FALSE StreptococcusStreptococcus mitis_parasanguinis_II_parasanguinis_clade_411 (SPP84) 0.390651531133996 0.400488832926056 0.975436763816392 0.329343654881451 1 FALSE ActinomycesActinomyces sp._HMT_169_sp._str._ChDCB197 (SPP87) -0.109600620218095 0.699446743607765 -0.156696161959053 0.875484312027506 1 FALSE StreptococcusStreptococcus parasanguinis_parasanguinis_I_parasanguinis_clade_721_sp._HMT_066 (SPP95) 0.669545280629298 0.634132029964676 1.05584523252452 0.291038929047915 1 FALSE MobiluncusMobiluncus multispecies_sppn34_2_nov_97.817% (SPPN34) -0.553736788666481 0.647320194859077 -0.855429496969472 0.392313419740825 1 FALSE