GroupHealthy-Dfx_0.1mM...1 GroupHealthy-Dfx_0.1mM...2 GroupHealthy-Dfx_0.1mM...3 GroupHealthy-Dfx_0.1mM...4 GroupHealthy-Dfx_0.1mM...5 GroupHealthy-Dfx_0.1mM...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PrevotellaPrevotella melaninogenica (SP10) 2.016957764603 0.469728960388736 4.29387569149198 1.75580807023909e-05 0.00180848231234627 TRUE FusobacteriumFusobacterium periodonticum (SP104) 0.259532602251992 0.421433683701413 0.615832602587768 0.538005007350714 1 FALSE AbiotrophiaAbiotrophia defectiva (SP107) -1.1090847874392 1.10029893058309 -1.00798497263962 0.313461676471589 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP108) -1.48357556276837 0.93483976488485 -1.58698380032124 0.112516313659034 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP109) -2.4359374895226 0.321031269285999 -7.58785116147825 0 0 TRUE SelenomonasSelenomonas flueggei (SP112) 0.455461490552698 0.490265373261436 0.929010114507561 0.352883844587358 1 FALSE PorphyromonasPorphyromonas catoniae (SP113) -3.39036567040268 0.485287768809609 -6.98629944603612 2.82231364446439e-12 3.2174375546894e-10 TRUE HaemophilusHaemophilus parainfluenzae (SP12) 2.78787523389901 1.0465155522493 2.66395967829332 0.00772268188581641 0.586923823322047 FALSE OribacteriumOribacterium sp._HMT_078 (SP122) -0.507995762079357 0.34356638590918 -1.47859564530752 0 0 TRUE FretibacteriumFretibacterium fastidiosum (SP123) 0.0892573943299951 0.385260867451578 0.231680406370921 0 0 TRUE StreptococcusStreptococcus pneumoniae (SP124) 0.088214096660352 0.263954659312181 0.334201703013019 0.738227358988903 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H23 (SP126) -1.24286399029064 0.323721222903629 -3.83930339550408 0.000123383885822795 0.0120916208106339 TRUE DialisterDialister invisus (SP13) -0.372840726043302 0.382625859580018 -0.974426366405405 0.329844883276524 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F85 (SP130) 0.22441243036605 0.623022346023639 0.360199649014732 0.718697837162391 1 FALSE StreptococcusStreptococcus sp._HMT_056 (SP131) 0.292893755104319 1.24912339796229 0.234479440207525 0.814612792672559 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G51 (SP133) 1.02371085463217 0.564054396881969 1.81491512217817 0 0 TRUE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP139) -0.240341746556973 0.263339287778081 -0.91266953968339 0.361416368717306 1 FALSE PrevotellaPrevotella buccae (SP140) 0.41285036671607 0.537787996193402 0.767682376026107 0.442675909117363 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP145) 0.0284835420653433 0.476146471428282 0.0598209663927615 0.95229822671257 1 FALSE VeillonellaVeillonella sp._Oral_Taxon_G61 (SP147) 0.991940794697399 0.193405821587817 5.12880525805166 2.91586783793497e-07 3.17829594334911e-05 TRUE SelenomonasSelenomonas sp._Oral_Taxon_E20 (SP149) -0.87419985830206 0.706994536697346 -1.23650157522546 0.216272180564118 1 FALSE PrevotellaPrevotella pallens (SP15) -3.97031853382376 1.08458695880484 -3.66067331124732 0.000251553331625126 0.0236460131727619 TRUE SelenomonasSelenomonas sputigena (SP151) 0.653149397887019 0.44645569472632 1.46296576704527 0.143476746371046 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP155) -2.50180049916418 0.345046182238634 -7.25062506975933 0 0 TRUE CampylobacterCampylobacter showae (SP156) -0.608947637353433 0.602943390280807 -1.00995822687405 0.312515304061058 1 FALSE StreptococcusStreptococcus parasanguinis_clade_411 (SP163) 0.22441243036605 0.408417978934712 0.549467560050591 0 0 TRUE PrevotellaPrevotella saccharolytica (SP167) -0.970093882452653 0.777702383704582 -1.24738447866344 0 0 TRUE BergeyellaBergeyella sp._HMT_900 (SP168) -1.2011429426393 0.333843824494298 -3.59791871081868 0 0 TRUE MegasphaeraMegasphaera micronuciformis (SP169) 1.2837637071487 1.17666501117883 1.09101884984459 0 0 TRUE StreptococcusStreptococcus pseudopneumoniae (SP170) 0.49058166243864 0.552418152054339 0.888062169235858 0.374507310758684 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP172) 0.359567466402105 0.510760635808868 0.70398429556474 0.481442553705356 1 FALSE SelenomonasSelenomonas sp._HMT_134 (SP174) 1.01345363507659 0.379613094868978 2.66970146387173 0 0 TRUE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP176) -2.64398892588027 0.734726117785205 -3.59860478874828 0 0 TRUE SelenomonasSelenomonas artemidis (SP177) -0.703924650380064 0.472103444368439 -1.49103900591478 0.135951254388549 1 FALSE StreptococcusStreptococcus intermedius (SP178) -0.774164994151948 0.607931900426631 -1.27344032055014 0.202861837232157 1 FALSE VeillonellaVeillonella dispar (SP18) 0.455461490552698 0.271893286403834 1.67514798389033 0 0 TRUE VeillonellaVeillonella parvula (SP19) 1.22348331660752 0.311955840808853 3.92197598684231 8.78257467448233e-05 0.00878257467448233 TRUE SelenomonasSelenomonas sp._Oral_Taxon_E83 (SP199) 0.625736698474695 0.441160366690497 1.41838829079062 0 0 TRUE BergeyellaBergeyella sp._HMT_322 (SP204) 0.394687638288047 0.40005326176314 0.986587727215507 0.323844789167112 1 FALSE PorphyromonasPorphyromonas pasteri (SP22) -2.47480769115331 0.923410097130151 -2.68007432325542 0.00736058152488144 0.579910699741074 FALSE StreptococcusStreptococcus mitis (SP25) -1.37492518490517 0.675818134165702 -2.03446033096244 0.0419052043256583 1 FALSE StreptococcusStreptococcus gordonii (SP26) 1.71037235497071 0.44228180448428 3.86715514323516 0.000110112380806253 0.010901125699819 TRUE StreptococcusStreptococcus sp._HMT_064 (SP27) 1.04347274461111 0.350207100452826 2.97958763046744 0.00288636658203245 0.239568426308693 FALSE SolobacteriumSolobacterium moorei (SP28) -0.915326198688895 0.730679700159949 -1.25270511619322 0.210313043360632 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP29) 0.725771562624808 0.664674422729718 1.0919204016369 0.274868089476685 1 FALSE StreptococcusStreptococcus cristatus_clade_578 (SP3) 1.83871286681781 0.333989084143028 5.5053082693876 3.68522838847513e-08 4.05375122732264e-06 TRUE SelenomonasSelenomonas sp._HMT_146 (SP30) -1.03392532068802 0.38565168981991 -2.68098221265629 0.00734064176887435 0.579910699741074 FALSE AlloprevotellaAlloprevotella sp._HMT_473 (SP31) -0.372840726043302 0.251228988774479 -1.48406729598387 0 0 TRUE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_071 (SP32) 0.739581635240383 0.344467665850725 2.14702774326831 0.0317910729960321 1 FALSE FusobacteriumFusobacterium sp._HMT_204 (SP33) -2.004360013754 1.70627882179628 -1.17469664872469 0.240116100616208 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP35) 0.827199316758374 0.256785650281421 3.22136114635618 0.00127583267878867 0.107169945018249 FALSE PorphyromonasPorphyromonas sp._HMT_278 (SP36) -2.95069876194071 0.490701950559659 -6.01321995678915 1.81873990869224e-09 2.03698869773531e-07 TRUE AnaeroglobusAnaeroglobus geminatus (SP38) 2.20094214482935 0.809784851689851 2.71793444917677 0.00656908511075146 0.525526808860117 FALSE CatonellaCatonella morbi (SP39) -0.00663662982059846 0.50248796866078 -0.0132075397512228 0.989462214314186 1 FALSE CampylobacterCampylobacter concisus (SP4) 1.66731852392442 0.381393012738202 4.37165461410514 1.23308481613709e-05 0.00128240820878258 TRUE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP40) -1.87277728282006 0.456422021731806 -4.10317029777433 0 0 TRUE PrevotellaPrevotella oralis (SP42) -0.385914297094396 1.1371511900377 -0.339369382431551 0.734331480710805 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F29 (SP43) -0.97972699897377 0.330339222352603 -2.96582098848684 0.00301876143572606 0.247538437729537 FALSE CampylobacterCampylobacter curvus (SP44) 4.49445441079153 0.45934493025448 9.78448680885968 1.31259458915937e-22 1.54886161520806e-20 TRUE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP45) -2.67358742547464 0.469980737832488 -5.68871702658497 1.27997366279178e-08 1.42077076569888e-06 TRUE SelenomonasSelenomonas sp._Oral_Taxon_H64 (SP46) -0.507995762079357 0.353465190760918 -1.43718752329126 0.15066471719944 1 FALSE StreptococcusStreptococcus sanguinis (SP47) -1.42112918650639 0.370596642758347 -3.83470604571305 0.000125714550283566 0.0121943113775059 TRUE AlloprevotellaAlloprevotella tannerae (SP48) -1.72052448198815 1.05349988536991 -1.63315108609057 0 0 TRUE SelenomonasSelenomonas dianae (SP5) -0.549628474409298 0.286127087161061 -1.92092429927794 0.0547412518312212 1 FALSE SelenomonasSelenomonas sp._HMT_481 (SP50) -0.492615376746739 0.291890143829466 -1.68767389773375 0.0914738450706417 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP53) -3.1154773385758 0.368157189277193 -8.46235637742793 2.62028341703708e-17 3.06573159793339e-15 TRUE PrevotellaPrevotella denticola (SP54) -0.543115933965299 0.890580229738409 -0.609845037908408 0.54196446385663 1 FALSE StreptococcusStreptococcus chosunense (SP56) 0.510264465598588 0.245978734192542 2.07442512164151 0.0380398462175291 1 FALSE CentipedaCentipeda sp._Oral_Taxon_D18 (SP57) -0.678270970001354 0.616547002593119 -1.10011234690726 0.271283174880746 1 FALSE PrevotellaPrevotella oulorum (SP60) -1.43219200282595 0.409820219634141 -3.49468360566619 0 0 TRUE EikenellaEikenella corrodens (SP62) 0.100537195122789 0.326462756294334 0.307959156701312 0.758113411131958 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP63) -5.856693848215 0.39593793330525 -14.7919493323711 1.65102010492945e-49 1.96471392486605e-47 TRUE SelenomonasSelenomonas sp._HMT_149 (SP64) -0.141791665856653 0.380674109201736 -0.372475202356123 0.709539071579268 1 FALSE ParvimonasParvimonas micra (SP67) -2.6490780832572 0.774245502640442 -3.42149624921674 0.000622775839856012 0.054181498067473 FALSE GranulicatellaGranulicatella adiacens (SP68) -0.32540424528205 0.269291237062231 -1.20837294533595 0.226903841509109 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_H27 (SP69) -1.57648003025804 0.93972740984879 -1.67759289953212 0 0 TRUE OribacteriumOribacterium sinus (SP70) -1.51208295391443 1.21535803194945 -1.2441460986513 0 0 TRUE SelenomonasSelenomonas infelix (SP71) 0.643899426902719 0.514928884646448 1.25046282331748 0.211130527724576 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G67 (SP72) -1.3714181505613 0.412062280176519 -3.32818172528146 0.000874148248787229 0.0743026011469144 FALSE ParvimonasParvimonas sp._HMT_110 (SP75) -0.372840726043302 0.372832800100339 -1.00002125870621 0 0 TRUE GemellaGemella morbillorum (SP78) -1.05581501718094 0.878356485906178 -1.20203474798924 0.229350065595921 1 FALSE FusobacteriumFusobacterium nucleatum (SP8) -1.83765711093412 0.750008808030468 -2.45018070622374 0 0 TRUE SelenomonasSelenomonas sp._Oral_Taxon_G55 (SP80) 1.26225086676951 0.348124948918766 3.62585580461816 0.000288006039763697 0.0267845616980238 TRUE SchaaliaSchaalia sp._HMT_180 (SP81) 0.686510550739347 0.569790201399588 1.20484794061578 0.228262008891604 1 FALSE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsps._yurii_&_margaretiae (SP83) -0.372840726043302 0.318387847923262 -1.17102687327804 0 0 TRUE LautropiaLautropia mirabilis (SP86) 3.36407217606189 0.496793874839472 6.77156532404695 0 0 TRUE PorphyromonasPorphyromonas sp._HMT_275 (SP88) -2.01840414636988 1.79859568952269 -1.12221115514044 0.261772670758851 1 FALSE FusobacteriumFusobacterium hwasookii (SP9) 1.62845496299221 0.471106592714757 3.4566592532875 0.000546915937552214 0.0481286025045948 TRUE StreptococcusStreptococcus constellatus (SP93) -0.468734750193896 0.329277975116561 -1.42352293689843 0.154584617788937 1 FALSE SelenomonasSelenomonas sp._HMT_136 (SP99) 0.68316043878818 0.386580330812629 1.76718882037301 0.0771966113480925 1 FALSE AbiotrophiaAbiotrophia defectiva_nov_97.500% (SPN1) -0.739044822266005 0.765033201009078 -0.966029737390751 0.334029300983804 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F85_nov_97.518% (SPN19) 1.19999223105506 0.314157970964448 3.81970964279898 0.000133608860156976 0.0128264505750697 TRUE GranulicatellaGranulicatella adiacens_nov_97.857% (SPN2) 0.275795990308469 0.434765673450046 0.6343554865312 0.525848852751539 1 FALSE StreptococcusStreptococcus sp._HMT_056_nov_97.857% (SPN36) 1.23031615712364 0.644588659860113 1.90868414810561 0.0563028492955675 1 FALSE StreptococcusStreptococcus gordonii_nov_97.857% (SPN4) 1.43104129124171 0.345781475311142 4.13857130418577 3.4947526250701e-05 0.0035646476775715 TRUE StreptococcusStreptococcus gordonii_nov_96.429% (SPN5) 1.37965773129929 0.312317341292836 4.41748679592431 0 0 TRUE SelenomonasSelenomonas artemidis_nov_97.857% (SPN57) -1.04447506622406 0.305653247696049 -3.41718949200473 0.000632712237947661 0.0544132524634989 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F87_nov_97.857% (SPN67) 0.455461490552698 0.271893286403834 1.67514798389033 0 0 TRUE PrevotellaPrevotella melaninogenica_nov_97.865% (SPN73) -0.141791665856654 0.760728335921388 -0.186389357621228 0.852139437584938 1 FALSE PrevotellaPrevotella pallens_nov_97.865% (SPN74) -0.372840726043302 0.638576538693634 -0.583862236476836 0.559313001936232 1 FALSE PorphyromonasPorphyromonas pasteri_sp._HMT_284 (SPP15) -0.497738542523772 0.793084480509904 -0.62759838927091 0.530267064147886 1 FALSE PorphyromonasPorphyromonas gingivalis_sp._Oral_Taxon_F92 (SPP22) 0.089257394329995 0.312299262999453 0.285807252545938 0 0 TRUE VeillonellaVeillonella dispar_parvula (SPP25) -0.87419985830206 0.535985622123966 -1.63101363584688 0.102887442305617 1 FALSE VeillonellaVeillonella dispar_parvula_sp._Oral_Taxon_E53 (SPP26) 0.536995835149622 0.246642171043981 2.17722635539834 0.0294636828045927 1 FALSE AggregatibacterAggregatibacter segnis_sp._HMT_513 (SPP29) 0.0892573943299951 0.236788446256534 0.376949955714033 0 0 TRUE StreptococcusStreptococcus mitis_oralis_oralis_subsp._dentisani_clade_398 (SPP31) 1.41891874318475 0.379532665643087 3.73859451802525 0.000185051919209315 0.0175799323248849 TRUE StreptococcusStreptococcus oralis_oralis_subsp._oralis (SPP32) 2.83856146244178 0.609510772749034 4.65711450781946 3.20672105980623e-06 0.000346325874459073 TRUE StreptococcusStreptococcus mitis_oralis_subsp._dentisani_clade_058 (SPP33) 0.844045354387945 0.697089479072715 1.21081350346976 0.225966888703406 1 FALSE StreptococcusStreptococcus sp._HMT_423_sp._str._C300 (SPP36) -1.14876686214309 0.250287048527243 -4.58979747015577 4.43676289641801e-06 0.000474733629916727 TRUE FusobacteriumFusobacterium nucleatum_nucleatum_subsp._vincentii (SPP38) -3.304238165007 1.6511217231444 -2.00120809913058 0.0453699685217823 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nucleatum_subsp._animalis (SPP39) -0.00184038400323203 1.44809259734958 -0.00127090215542877 0.998985967064869 1 FALSE ParvimonasParvimonas micra_sp._Oral_Taxon_110 (SPP42) -3.668457363171 1.0527438510512 -3.48466282610714 0 0 TRUE FusobacteriumFusobacterium nucleatum_nucleatum_ss_polymorphum_nucleatum_subsp._polymorphum (SPP43) 0.0029311601716909 0.148782328580964 0.0197009967490583 0.984281895644145 1 FALSE FusobacteriumFusobacterium hwasookii_nucleatum_nucleatum_ss_polymorphum_nucle ...(4 species) (SPP44) 1.34910315606612 0.631147721254629 2.13753945492239 0.0325541402056775 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella rimae (SPP46) -1.2687898906382 0.457539552185857 -2.77307149639121 0.00555299190111602 0.449792343990397 FALSE StreptococcusStreptococcus infantis_infantis_clade_638 (SPP47) 1.02371085463217 1.23088586088715 0.831686257159819 0.40558605978755 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP6) -0.616469895557567 0.463623404978108 -1.32967811576872 0.183624348236487 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP8) -1.61873059880443 0.352738136045723 -4.58904335366393 0 0 TRUE FusobacteriumFusobacterium multispecies_sppn8_3_nov_97.436% (SPPN8) -0.468734750193896 0.526240823572522 -0.890722895673066 0.37307784864459 1 FALSE