GroupPerio-Fe_0.1_mM...1 GroupPerio-Fe_0.1_mM...2 GroupPerio-Fe_0.1_mM...3 GroupPerio-Fe_0.1_mM...4 GroupPerio-Fe_0.1_mM...5 GroupPerio-Fe_0.1_mM...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PrevotellaPrevotella melaninogenica (SP10) 0.127700646329285 0.7032612405098 0.18158351260296 0.855909588769579 1 FALSE SelenomonasSelenomonas sp._HMT_138 (SP101) 0.895229010660634 0.358425845337834 2.49766868741521 0.0125012971022208 1 FALSE PrevotellaPrevotella baroniae (SP102) -0.0201947939801697 0.265065564097718 -0.0761879199544937 0.939269593235125 1 FALSE FusobacteriumFusobacterium periodonticum (SP104) -0.572937486181347 0.933662926317754 -0.61364489263908 0.539450011178541 1 FALSE AlloprevotellaAlloprevotella rava (SP105) 0.314885294252868 0.671647782754719 0.468825033503999 0.639194704779942 1 FALSE PrevotellaPrevotella maculosa (SP106) -0.0885967441893505 0.223846286651901 -0.395792780458876 0.692257903205902 1 FALSE AbiotrophiaAbiotrophia defectiva (SP107) -0.742322617918051 0.355717590811189 -2.08683134344084 0.0369033827942679 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP108) -0.299768481018884 0.262486084722412 -1.14203570576284 0.253439178314825 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP109) 0.493904742551988 0.456837062116738 1.08113982754267 0.279634919393273 1 FALSE PrevotellaPrevotella intermedia (SP11) -2.16764975702673 0.337515639412635 -6.42236834061675 1.34170281906428e-10 1.82471583392743e-08 TRUE SelenomonasSelenomonas flueggei (SP112) 2.08129605415124 0.149820296153147 13.8919499399716 7.08790914408866e-44 1.00648309846059e-41 TRUE HaemophilusHaemophilus parainfluenzae (SP12) 1.75530128719141 0.447431646587082 3.92306020501789 0 0 TRUE OribacteriumOribacterium sp._HMT_078 (SP122) -0.334397474044012 0.338516261474371 -0.987832822528467 0 0 TRUE FretibacteriumFretibacterium fastidiosum (SP123) 0.358749706515933 0.420658681464041 0.85282848619065 0.393754424377299 1 FALSE StreptococcusStreptococcus pneumoniae (SP124) -0.103348413857364 0.171206707105786 -0.603646992600039 0 0 TRUE PrevotellaPrevotella marshii (SP125) 1.59301049294358 0.58174318682219 2.73833975030374 0.00617502462874714 0.654552610647197 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H23 (SP126) -1.22864160508332 0.571562177896398 -2.14962020336137 0.0315852689960718 1 FALSE DialisterDialister invisus (SP13) 0.113371150974588 0.26815405604394 0.422783651484322 0.672453116628605 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F85 (SP130) 0.589798766702582 0.29414717175199 2.00511452545894 0 0 TRUE SelenomonasSelenomonas sp._Oral_Taxon_G51 (SP133) 1.0073864228677 0.473947214624686 2.12552451366434 0.0335428708269892 1 FALSE SelenomonasSelenomonas sp._HMT_919 (SP134) -0.140423625560772 0.200951335388391 -0.698794189595044 0.484680660244072 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP139) 0.493904742551988 0.367300701186137 1.34468772032562 0 0 TRUE PrevotellaPrevotella buccae (SP140) 0.454643730666526 0.329815026836369 1.37848094741932 0.168054846306835 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP145) -0.465095264424771 0.226547060676217 -2.05297417250312 0.0400750824611388 1 FALSE VeillonellaVeillonella sp._Oral_Taxon_G61 (SP147) -0.238503449893419 0.421240752022651 -0.566192726482916 0.571262773865363 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_E20 (SP149) 0.127700646329285 0.244663766326111 0.521943433826949 0.601709715881448 1 FALSE PrevotellaPrevotella pallens (SP15) -0.334397474044012 0.288788927559891 -1.15793038489906 0 0 TRUE PrevotellaPrevotella sp._HMT_314 (SP150) 1.27236304782433 0.890656459944771 1.42856769702567 0.153128524199141 1 FALSE SelenomonasSelenomonas sputigena (SP151) 1.89045632322746 0.497962298608792 3.79638444217368 0.000146821754174642 0.0182058975176556 TRUE CapnocytophagaCapnocytophaga sputigena (SP155) 0.40550167035208 0.176930797258291 2.29186595344456 0.0219133794307946 1 FALSE CampylobacterCampylobacter showae (SP156) 0.454643730666527 0.462327290876575 0.983380690775403 0.325420110026727 1 FALSE StreptococcusStreptococcus parasanguinis_clade_411 (SP163) 1.67058149372036 0.439046235939032 3.80502406573951 0.000141790404149896 0.017723800518737 TRUE BilophilaBilophila wadsworthia (SP166) 0.358749706515933 0.302511305696631 1.18590512076828 0.235659770690612 1 FALSE PrevotellaPrevotella saccharolytica (SP167) 0.995263874810746 0.251110812298879 3.96344492576511 7.38759125332856e-05 0.00938224089172727 TRUE BergeyellaBergeyella sp._HMT_900 (SP168) -0.0425745615927121 0.656072911856457 -0.0648930337212689 0.9482591671898 1 FALSE MegasphaeraMegasphaera micronuciformis (SP169) 0.724953802738637 0.301366491844177 2.40555543618127 0 0 TRUE PorphyromonasPorphyromonas gingivalis (SP17) -0.153379706901246 0.636533379332928 -0.240960980022735 0.809585358974945 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP172) 1.16553908273274 0.20859124519805 5.58767019021391 2.30136180021101e-08 3.06081119428064e-06 TRUE SelenomonasSelenomonas sp._HMT_134 (SP174) 0.297975854251282 0.453448970089531 0.657132056540889 0.511096008240501 1 FALSE SelenomonasSelenomonas artemidis (SP177) -1.20196070252547 0.427502038646493 -2.81159057470459 0.00492972089914104 0.537339578006373 FALSE StreptococcusStreptococcus intermedius (SP178) 0.358749706515933 0.294599042227396 1.21775584809614 0 0 TRUE VeillonellaVeillonella dispar (SP18) 0.399037940580531 0.33076097737363 1.20642387668898 0.227654094280964 1 FALSE PrevotellaPrevotella pleuritidis (SP186) 0.493904742551988 0.42619416936603 1.15887259388527 0.246508121540159 1 FALSE VeillonellaVeillonella parvula (SP19) 0.09253901765163 0.171625273648827 0.539192251142333 0.58975420657084 1 FALSE MogibacteriumMogibacterium diversum (SP195) 1.08176760663911 0.826611026812846 1.30867792897715 0.190643471043476 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_E83 (SP199) -0.970911642338825 0.306411090370766 -3.16865698680813 0.00153145017922125 0.174585320431223 FALSE BergeyellaBergeyella sp._HMT_322 (SP204) 0.358749706515933 0.270228738230039 1.32757792108158 0 0 TRUE PorphyromonasPorphyromonas pasteri (SP22) -0.0463200689381213 0.21316933786668 -0.21729236203328 0.82798050911829 1 FALSE StreptococcusStreptococcus mitis (SP25) -0.469552510080067 0.388090220491401 -1.20990554589476 0 0 TRUE StreptococcusStreptococcus gordonii (SP26) 1.47560362841379 0.393069887705229 3.75404902428033 0.000174000809347819 0.0212280987404339 TRUE StreptococcusStreptococcus sp._HMT_064 (SP27) -0.954030398065907 0.680728731285137 -1.40148396008614 0.161069400753937 1 FALSE SolobacteriumSolobacterium moorei (SP28) 1.15852981883514 0.370609027678421 3.12601618501427 0.00177191799505787 0.200226733441539 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP29) -0.700601570266716 0.196427898384012 -3.56671112418591 0 0 TRUE StreptococcusStreptococcus cristatus_clade_578 (SP3) -0.95145638270127 0.350389516688299 -2.71542479836139 0.00661908071755931 0.695003475343728 FALSE SelenomonasSelenomonas sp._HMT_146 (SP30) 0.262855682365339 0.452041461720923 0.581485780894185 0.560913098721796 1 FALSE AlloprevotellaAlloprevotella sp._HMT_473 (SP31) -1.01841034281781 0.776835253321502 -1.31097338652361 0.189866755143123 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_071 (SP32) 0.433784236896764 0.397572426997677 1.09108229706106 0.275236671745527 1 FALSE FusobacteriumFusobacterium sp._HMT_204 (SP33) 1.68402889997239 1.04591518183288 1.6101008276993 0.107375846434958 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP35) 0.156704438659161 0.738366341226885 0.212231286706241 0.831926599392176 1 FALSE PorphyromonasPorphyromonas sp._HMT_278 (SP36) -0.0366515952169369 0.228145775586322 -0.160649896421463 0.872369153591842 1 FALSE PorphyromonasPorphyromonas endodontalis (SP37) 1.93393225249418 1.30417085363746 1.48288258942473 0.138105607965609 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP38) 0.934460626776127 0.334031044896262 2.79752628102677 0.00514955776324774 0.556152238430756 FALSE CatonellaCatonella morbi (SP39) -0.658083733905872 1.44880802450011 -0.454224246951513 0.649667432945797 1 FALSE CampylobacterCampylobacter concisus (SP4) 0.19067667919484 0.414445076797093 0.46007707623993 0.645460897653134 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP40) 0.00615294179998144 0.410201431496404 0.0149998057723389 0.988032335336695 1 FALSE PrevotellaPrevotella oralis (SP42) 0.089924417893617 0.504979150593621 0.178075506261808 0.858663677743886 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F29 (SP43) 0.358749706515933 0.294599042227396 1.21775584809614 0 0 TRUE CampylobacterCampylobacter curvus (SP44) 0.0318066221786911 0.382324919060365 0.0831926473871014 0.933698359009503 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP45) -0.607403169801432 0.684752229787129 -0.887040805971902 0.375056931436592 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H64 (SP46) 0.589798766702582 0.271226014830928 2.17456561853124 0 0 TRUE StreptococcusStreptococcus sanguinis (SP47) 0.383999009261192 0.292356339008064 1.31346223093388 0.189027239731555 1 FALSE AlloprevotellaAlloprevotella tannerae (SP48) -0.284261611376332 0.556681690916713 -0.510635819382213 0.609606089307271 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_D95 (SP49) -0.0776185342936542 0.493100547981923 -0.157409142235428 0.874922408814566 1 FALSE SelenomonasSelenomonas dianae (SP5) 1.18222410117241 0.174879946331659 6.76020393401954 1.37797641598218e-11 1.90160745405541e-09 TRUE SelenomonasSelenomonas sp._HMT_481 (SP50) 0.127700646329285 0.276540796320508 0.461778688816969 0.644240035036053 1 FALSE DialisterDialister pneumosintes (SP51) -0.176862670395414 0.628655689514754 -0.281334716833519 0.778453684964528 1 FALSE StreptococcusStreptococcus cristatus (SP52) 1.44797170286181 0.642092714313126 2.25508196960429 0.0241281841585334 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP53) 0.477641354495511 0.267587963525483 1.78498818931377 0.0742632326355837 1 FALSE PrevotellaPrevotella denticola (SP54) -2.55554811732145 0.704408806549889 -3.62793323075874 0.000285699118415871 0.0339981950914886 TRUE StreptococcusStreptococcus sp._Oral_Taxon_F53 (SP55) 0.298195080390939 0.293457550198497 1.01614383473602 0.309560897590274 1 FALSE StreptococcusStreptococcus chosunense (SP56) 0.099328765721041 0.265314596093302 0.3743810826228 0.708120815203962 1 FALSE PrevotellaPrevotella oulorum (SP60) -0.483159841586819 0.545352320555223 -0.885959082552201 0.375639576603844 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP61) 0.0499802351381629 0.302903063923992 0.165004059353802 0.868940786952215 1 FALSE EikenellaEikenella corrodens (SP62) -0.00745438970677029 0.5163459893209 -0.0144368114809497 0.988481491131051 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP63) 0.820146567992241 0.502356570623871 1.63259846880018 0.102553473492842 1 FALSE SelenomonasSelenomonas sp._HMT_149 (SP64) 1.18705192311193 0.606283632604259 1.9579151724961 0.0502399672416479 1 FALSE ParvimonasParvimonas micra (SP67) -0.557841641641937 0.152392250262328 -3.66056437044318 0.000251660318208425 0.030199238185011 TRUE GranulicatellaGranulicatella adiacens (SP68) -1.13753050647063 0.531727930582889 -2.13930929906889 0.0324106270835424 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_H27 (SP69) 0.0533194625578814 0.66875976209491 0.0797288736254954 0.936452894714495 1 FALSE OribacteriumOribacterium sinus (SP70) 0.256455838862977 0.277375897680721 0.924578671064546 0.355185111892243 1 FALSE SelenomonasSelenomonas infelix (SP71) -0.653413715492786 0.369026810549586 -1.77064022670783 0.0766205480952988 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G67 (SP72) -1.1807220977301 0.519233761113387 -2.27397019638764 0.0229677785270484 1 FALSE ParvimonasParvimonas sp._HMT_110 (SP75) -0.172424445860134 0.595698645204002 -0.28944911533429 0.772237714069623 1 FALSE GemellaGemella morbillorum (SP78) -0.669668201878092 0.307795476796271 -2.17569214742341 0.0295782877694777 1 FALSE FusobacteriumFusobacterium nucleatum (SP8) -0.00745438970677029 0.445478023537058 -0.0167334622875065 0.986649251849335 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G55 (SP80) 0.358749706515933 0.244100132617746 1.46968255473144 0.141647749690928 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP81) 0.26285568236534 0.446429576660228 0.588795402696617 0.555998530195315 1 FALSE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsps._yurii_&_margaretiae (SP83) -0.127999692892298 0.304505098764604 -0.420353200690565 0.674227450782551 1 FALSE MegasphaeraMegasphaera sp._HMT_123 (SP84) 0.724953802738636 0.264107124594537 2.74492331038627 0.00605250397523526 0.647617925350173 FALSE PorphyromonasPorphyromonas sp._HMT_275 (SP88) 0.299875194622827 0.460411313820639 0.651320212212787 0.514839803550601 1 FALSE ActinomycesActinomyces odontolyticus (SP89) 0.856164019559023 0.670203720895373 1.27746831726809 0.201436958982384 1 FALSE FusobacteriumFusobacterium hwasookii (SP9) -0.0425745615927123 0.676723016148917 -0.0629128322470762 0.949835916432689 1 FALSE StreptococcusStreptococcus anginosus (SP92) 1.14648627811943 0.136591134300975 8.393562905724 4.71627132853484e-17 6.60277985994877e-15 TRUE StreptococcusStreptococcus constellatus (SP93) -0.774982754038119 0.348335880090208 -2.22481460663031 0.0260936864249432 1 FALSE CampylobacterCampylobacter sp._Oral_Taxon_E65 (SP98) 0.506027290608946 0.320928831585249 1.57675858572566 0.114851084266716 1 FALSE SelenomonasSelenomonas sp._HMT_136 (SP99) 1.23242931455346 0.285392335827516 4.3183686449741 1.57186727197346e-05 0.00201199010812603 TRUE BacteroidesBacteroides heparinolyticus_nov_95.745% (SPN10) 0.868468733573699 0.307215591024952 2.82690318768087 0.0047000534970092 0.517005884671012 FALSE AlloprevotellaAlloprevotella sp._HMT_473_nov_97.153% (SPN14) 1.3548054895139 0.684772873145376 1.9784742396276 0.0478752318670237 1 FALSE SelenomonasSelenomonas sp._HMT_481_nov_96.786% (SPN24) -0.11687684056239 0.121427579672046 -0.962523018889557 0.335786945983922 1 FALSE SelenomonasSelenomonas dianae_nov_97.527% (SPN3) -0.419665585228598 0.350776746126315 -1.19638941253385 0.231544631022213 1 FALSE PorphyromonasPorphyromonas pasteri_nov_97.500% (SPN30) 0.467223839994143 0.625825590098058 0.746571964116929 0.455321976921199 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F30_nov_97.857% (SPN40) -2.28799288186597 0.466623462246561 -4.90329584125585 0 0 TRUE SelenomonasSelenomonas infelix_nov_97.509% (SPN47) -0.334397474044012 0.288788927559891 -1.15793038489906 0 0 TRUE SelenomonasSelenomonas artemidis_nov_97.857% (SPN57) -1.15920925735091 0.4970268911599 -2.33228679970553 0.0196856084904345 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F87_nov_97.857% (SPN67) -1.64717757862585 0.444227171346779 -3.70796224290389 0.000208933798891435 0.0252809896658637 TRUE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP11) -2.47084819911558 0.651384136543116 -3.79322746824682 0.00014870182100268 0.0182903239833297 TRUE FusobacteriumFusobacterium nucleatum_nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP12) -1.82303351359554 0.527715892087611 -3.45457383590199 0 0 TRUE SelenomonasSelenomonas sp._HMT_892_sp._Oral_Taxon_G51 (SPP13) 1.22891919060462 0.111944638886327 10.9779191110037 4.88036043672103e-28 6.88130821577665e-26 TRUE CapnocytophagaCapnocytophaga ochracea_sp._HMT_335 (SPP16) 1.49248216706999 0.300320433581517 4.96963243316867 6.70799417552112e-07 8.85455231168788e-05 TRUE SelenomonasSelenomonas noxia_sp._HMT_937 (SPP18) -2.64772428280297 0.430168237506522 -6.15509015298422 0 0 TRUE PorphyromonasPorphyromonas gingivalis_sp._Oral_Taxon_F92 (SPP22) 0.263199980493773 0.512850801749834 0.513209650049764 0.607804676370601 1 FALSE VeillonellaVeillonella dispar_parvula (SPP25) 0.451732504010275 0.345823205873156 1.30625272202226 0.191466629053083 1 FALSE VeillonellaVeillonella dispar_parvula_sp._Oral_Taxon_E53 (SPP26) 0.216325979814316 0.256470703356285 0.84347247846784 0.398964251521912 1 FALSE AggregatibacterAggregatibacter segnis_sp._HMT_513 (SPP29) 0.568285926323391 0.186327934214105 3.04992339833697 0.00228899739845778 0.256367708627271 FALSE StreptococcusStreptococcus mitis_oralis_oralis_subsp._dentisani_clade_398 (SPP31) -1.45823999896072 0.246866740036516 -5.90699256912868 3.48409461004122e-09 4.66868677745523e-07 TRUE StreptococcusStreptococcus oralis_oralis_subsp._oralis (SPP32) 0.358749706515933 0.270228738230039 1.32757792108158 0 0 TRUE StreptococcusStreptococcus sp._HMT_423_sp._str._C300 (SPP36) -1.12860674093321 0.354428960765716 -3.18429605327663 0.00145106522181726 0.166872500508985 FALSE StreptococcusStreptococcus cristatus_cristatus_clade_578 (SPP37) 2.00760588683105 0.625346588774497 3.2103891231987 0.00132555395962354 0.153764259316331 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_subsp._vincentii (SPP38) -0.601344072772696 0.466223623491948 -1.28981896770635 0.197113520664987 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nucleatum_subsp._animalis (SPP39) -0.00897299521872399 0.639606139992458 -0.0140289385258712 0.988806893701583 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_polymorphum_nucleatum_subsp._polymorphum (SPP43) 0.20516386207198 0.266336738004326 0.770317544658999 0.441111551554319 1 FALSE FusobacteriumFusobacterium hwasookii_nucleatum_nucleatum_ss_polymorphum_nucle ...(4 species) (SPP44) 2.48404178852204 0.830776106255515 2.99002555540282 0.00278954107780989 0.309639059636898 FALSE Bacteroidaceae_[G-1]_PhocaeicolaBacteroidaceae_[G-1]_Phocaeicola abscessus_bacterium_HMT_272 (SPP45) 0.956002862925285 0.114512937145321 8.34842670843456 6.91782515854302e-17 9.61577697037479e-15 TRUE Atopobium_LancefieldellaAtopobium_Lancefieldella rimae (SPP46) 1.44442557012679 0.300984745056732 4.79899926441301 1.59460380131106e-06 0.000207298494170437 TRUE Eubacterium_[XI][G-7]_PeptoanaerobacterEubacterium_[XI][G-7]_Peptoanaerobacter [Eubacterium] yurii_yurii (SPP48) -0.111125648994818 0.274217422397168 -0.405246493907549 0.685296332306414 1 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP6) -1.27647903229072 0.479649505931075 -2.66127456925631 0.00778454487690274 0.809592667197885 FALSE OribacteriumOribacterium asaccharolyticum_parvum (SPP7) 2.297786759837 0.347005848834494 6.62175224871481 3.54965641585478e-11 4.86302928972104e-09 TRUE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP8) 1.69173801836992 0.361506677807812 4.67968677267228 2.87313520618735e-06 0.000370634441598168 TRUE FusobacteriumFusobacterium multispecies_sppn1_2_nov_77.143% (SPPN1) 0.664179950473985 0.469299133996196 1.41525927145514 0 0 TRUE StreptococcusStreptococcus multispecies_sppn6_2_nov_97.509% (SPPN6) -0.440548717750191 0.193111814163276 -2.28131416847292 0.0225298629113131 1 FALSE FusobacteriumFusobacterium multispecies_sppn8_3_nov_97.436% (SPPN8) 0.0318066221786911 0.324435223651534 0.0980368956881623 0.92190299594659 1 FALSE multigenusmultigenus multispecies_sppn9_2_nov_96.071% (SPPN9) -0.661340558381255 0.403327108306773 -1.63971264207273 0.101064929117988 1 FALSE