GroupHealthy-Dfx_1mM...1 GroupHealthy-Dfx_1mM...2 GroupHealthy-Dfx_1mM...3 GroupHealthy-Dfx_1mM...4 GroupHealthy-Dfx_1mM...5 GroupHealthy-Dfx_1mM...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas pasteri (SP10) 1.35901746706994 0.661358094275106 2.05488899105335 0.0398897280342885 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G67 (SP101) -0.721822919603875 0.337693175071055 -2.13751112811799 0.0325564415880407 1 FALSE PrevotellaPrevotella oralis (SP102) 0.235628164527288 0.610676545525787 0.38584773928793 0.699609436994729 1 FALSE SelenomonasSelenomonas sp._HMT_481 (SP104) -0.0923453173331792 0.522737587153393 -0.176657121283458 0.859777723313203 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP105) -0.10389502913757 0.241054946031949 -0.431001441156074 0 0 TRUE PrevotellaPrevotella oulorum (SP108) -1.04116484093526 0.797110241778303 -1.30617421074968 0.191493320790353 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F29 (SP110) -0.361432146442301 0.230481752339757 -1.56815948669771 0.116843916595887 1 FALSE CapnocytophagaCapnocytophaga sputigena (SP111) -1.6483420501225 0.876201648329737 -1.88123596122497 0.0599398279035663 1 FALSE PrevotellaPrevotella salivae (SP124) -1.14173346554103 0.343496938860623 -3.32385339248772 0.000887828562057748 0.0932219990160636 FALSE MegasphaeraMegasphaera micronuciformis (SP127) 0.397464103121188 0.753109163896881 0.52776426336994 0 0 TRUE SelenomonasSelenomonas sp._HMT_136 (SP130) -0.855932057485051 0.196524995483108 -4.35533431959102 1.32863979004721e-05 0.00146150376905193 TRUE SlackiaSlackia exigua (SP135) 0.0312600068984851 0.309542055395596 0.100987915385309 0 0 TRUE StreptococcusStreptococcus constellatus (SP136) 0.201535214820482 0.474923605397437 0.424352911773733 0.671308456372237 1 FALSE PorphyromonasPorphyromonas sp._HMT_275 (SP14) 3.37700381442706 1.10008931782613 3.06975420968572 0.00214235000048735 0.21851970004971 FALSE OribacteriumOribacterium sp._HMT_078 (SP141) 0.127154031049079 0.227682415346004 0.558471021382329 0 0 TRUE StreptococcusStreptococcus pneumoniae (SP142) 0.240796226705943 0.369960523199723 0.650870056684261 0.515130372050194 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_H27 (SP144) -0.0970219334033244 1.06106630174369 -0.0914381441045526 0.927144454070948 1 FALSE CampylobacterCampylobacter curvus (SP145) 3.33385278488291 0.259680948222414 12.8382648311478 1.0009276286559e-37 1.14105749666773e-35 TRUE SelenomonasSelenomonas sp._Oral_Taxon_H64 (SP149) -0.875564233468438 0.336741613658401 -2.60010701961128 0.00931946916370863 0.913307978043445 FALSE PorphyromonasPorphyromonas endodontalis (SP15) -0.565993149510867 0.153106127532359 -3.69673741105655 0 0 TRUE StomatobaculumStomatobaculum longum (SP156) -1.16324630592022 0.426081365677625 -2.73010368353057 0 0 TRUE SelenomonasSelenomonas sp._Oral_Taxon_G55 (SP158) -0.601113321396809 0.433621634959565 -1.38626229167016 0.16566682670383 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP16) 0.139213916574913 0.245308890831575 0.567504569862878 0.570371422685506 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP164) -0.00386016498745739 0.512716739519288 -0.00752884524713705 0.993992907367206 1 FALSE FusobacteriumFusobacterium hwasookii (SP17) -0.00668087124827776 0.448169907348484 -0.0149070054431006 0.988106371008793 1 FALSE PorphyromonasPorphyromonas sp._HMT_278 (SP18) 0.467704446893072 0.811395845627226 0.576419573027918 0.56433161772632 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP183) -1.11873584171204 0.468400307046292 -2.38841825012185 0.0169210724106923 1 FALSE SelenomonasSelenomonas sputigena (SP185) -0.470099125360273 0.37361744267959 -1.25823655873429 0.208306217080799 1 FALSE MycoplasmaMycoplasma salivarium (SP186) 0.031260006898485 0.47003196247817 0.0665061302079788 0 0 TRUE PrevotellaPrevotella pallens (SP19) 0.0566814731109654 0.250005094003883 0.226721272767686 0.82064048453819 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP192) 0.493358127271782 0.424395256188916 1.16249680004003 0 0 TRUE StreptococcusStreptococcus mitis (SP2) -0.429340634928003 0.266839555271245 -1.60898422458984 0.107619791138768 1 FALSE PrevotellaPrevotella maculosa (SP20) -0.797042209697515 0.492969788820566 -1.61681755712545 0 0 TRUE SelenomonasSelenomonas sp._Oral_Taxon_H23 (SP200) -0.701148185546921 0.595512677571791 -1.17738582561476 0.239041544753769 1 FALSE PrevotellaPrevotella intermedia (SP21) -0.10389502913757 0.299495701569916 -0.346899900709646 0 0 TRUE OribacteriumOribacterium sinus (SP22) 0.110056266253229 0.947510843744959 0.116153041392371 0.907531252303389 1 FALSE ParvimonasParvimonas micra (SP23) -0.0093235497833174 0.19578342518788 -0.0476217523233655 0.96201769584811 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP24) 0.757332650052035 0.561257045009246 1.34935081311907 0.177224311640803 1 FALSE PrevotellaPrevotella buccae (SP25) -0.116017577194528 0.311692328402178 -0.372218263405028 0.709730349243638 1 FALSE StreptococcusStreptococcus sp._HMT_056 (SP26) 0.259397840428882 0.790757342052873 0.328037220312699 0.742883520565131 1 FALSE CentipedaCentipeda sp._Oral_Taxon_D18 (SP27) 0.464354334941905 0.581770814033848 0.79817399522364 0.424769526005978 1 FALSE GranulicatellaGranulicatella adiacens (SP28) 0.0901585053921347 0.1640692992637 0.549514783062658 0.58265222230924 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP29) 0.382809529194959 0.402420420502581 0.951267653656518 0.34146852269604 1 FALSE GemellaGemella morbillorum (SP31) -1.10862793160278 0.608668996552217 -1.82139707769339 0.0685465190789236 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP32) 0.449730895342045 0.509383331957213 0.882892837529717 0.377294173837573 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP33) -0.760971014817438 0.364302513467923 -2.08884371280749 0.0367217940399965 1 FALSE PrevotellaPrevotella melaninogenica (SP34) 0.296933136334367 0.303690910912917 0.977747853703506 0.328199047598143 1 FALSE CampylobacterCampylobacter showae (SP35) -0.0921979225338134 0.375054025333905 -0.245825711247149 0.805817152972863 1 FALSE EikenellaEikenella corrodens (SP37) -0.165202641857879 0.186990995949773 -0.883479126996329 0.376977455281903 1 FALSE CampylobacterCampylobacter concisus (SP38) 0.604770291594528 0.319413491509634 1.89337741726632 0.0583076964030807 1 FALSE PrevotellaPrevotella denticola (SP39) 1.03086831657915 1.06913912732064 0.964204087416202 0.334943615538122 1 FALSE FusobacteriumFusobacterium nucleatum (SP4) -0.334944089324218 0.314046174951609 -1.06654408185621 0.286177762715145 1 FALSE HaemophilusHaemophilus parainfluenzae (SP40) -0.245745651362538 0.275985237855481 -0.890430420380751 0.373234814052156 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP41) -0.470099125360273 0.550033706775682 -0.854673303779893 0.392732033666874 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_071 (SP42) 0.347095426590885 0.419214961906702 0.827965263959574 0.407690172140689 1 FALSE AlloprevotellaAlloprevotella rava (SP43) -0.565993149510867 0.38535571801098 -1.46875503089003 0 0 TRUE StreptococcusStreptococcus gordonii (SP44) -0.854106258258219 0.570715304632615 -1.49655397590578 0.134509353303066 1 FALSE SelenomonasSelenomonas sp._HMT_146 (SP47) -0.57227027555455 0.178448027076344 -3.20692968664607 0.00134159782734146 0.139526174043512 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP48) -0.470099125360273 0.509626311201904 -0.922438883211485 0.356299695711092 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP49) 0.442516132571696 0.922373185678746 0.47975823608322 0.63139931287921 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP52) -0.98358080567599 0.536830564667007 -1.83219971144173 0.0669216718565944 1 FALSE AlloprevotellaAlloprevotella tannerae (SP53) 0.765954669194189 1.35240843169864 0.56636342338693 0.571146753851435 1 FALSE StreptococcusStreptococcus cristatus_clade_578 (SP56) -0.0873288956204865 0.152415922122617 -0.572964388525178 0.566668806282447 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G51 (SP61) -0.10389502913757 0.331962226104046 -0.312972443753303 0.754301597889089 1 FALSE SelenomonasSelenomonas sp._HMT_892 (SP62) -0.93219724573357 0.190795588214873 -4.88584277265224 1.02987361349774e-06 0.000115345844711747 TRUE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsps._yurii_&_margaretiae (SP64) -0.565993149510867 0.335278106312262 -1.68813035761938 0 0 TRUE StreptococcusStreptococcus chosunense (SP68) -0.0355179869146737 0.376626876729664 -0.0943055026319002 0.924866478930295 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP69) -1.37119143281012 0.539554615608836 -2.54133945506678 0.0110428647961967 1 FALSE VeillonellaVeillonella parvula (SP7) -0.598165664469881 0.465282134962002 -1.28559774709324 0.1985834834148 1 FALSE SelenomonasSelenomonas dianae (SP70) 0.0761422874679479 0.365412669207024 0.208373419655052 0.834937408857946 1 FALSE SolobacteriumSolobacterium moorei (SP71) -0.618942883047138 0.6599137276082 -0.937914847279269 0.348288172416607 1 FALSE FusobacteriumFusobacterium sp._HMT_204 (SP72) -3.45660773160592 0.913292768473798 -3.78477510271131 0.000153847640627616 0.0167693928284102 TRUE SelenomonasSelenomonas infelix (SP74) 0.131085829177093 0.448461954212908 0.292300891849702 0.770056576978743 1 FALSE ParvimonasParvimonas sp._HMT_110 (SP76) -0.565993149510867 0.153106127532359 -3.69673741105655 0 0 TRUE PorphyromonasPorphyromonas catoniae (SP77) -1.96892271504852 0.29640817913462 -6.64260588488786 3.08185112375584e-11 3.4824917698441e-09 TRUE CatonellaCatonella morbi (SP78) -0.565993149510867 0.153106127532359 -3.69673741105655 0 0 TRUE SchaaliaSchaalia sp._HMT_180 (SP79) -0.871423393468919 0.31793376017273 -2.7408960690286 0.00612718851951066 0.612718851951066 FALSE AbiotrophiaAbiotrophia defectiva (SP81) 0.0559626642830588 0.45967890864214 0.121742945414591 0.903102600658089 1 FALSE SelenomonasSelenomonas flueggei (SP82) -0.491611965739464 0.54316294169968 -0.90509113932018 0.365417105896194 1 FALSE VeillonellaVeillonella sp._Oral_Taxon_G61 (SP83) 0.474305322658466 0.436194769333531 1.0873704959442 0.276873104819031 1 FALSE SelenomonasSelenomonas sp._HMT_149 (SP84) -0.409325273095622 0.627032058133783 -0.652797999378029 0.513886513563918 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP85) -1.17536885397718 0.57403346772497 -2.04756154486156 0.0406029806106996 1 FALSE StreptococcusStreptococcus pseudopneumoniae (SP86) 0.127154031049078 0.41637870490101 0.305380725652883 0.760076199822218 1 FALSE DialisterDialister invisus (SP88) 0.0705210187839462 0.443203658260003 0.159116508786973 0.873577081791829 1 FALSE FusobacteriumFusobacterium periodonticum (SP89) -0.701148185546921 0.635206422021175 -1.10381155044989 0.26967489334618 1 FALSE VeillonellaVeillonella dispar (SP9) 0.031260006898485 0.380387896831123 0.0821792889808037 0 0 TRUE StreptococcusStreptococcus sanguinis (SP90) -0.431544328428241 0.301850161177243 -1.42966406492937 0.152813458656622 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP91) -2.64608509790112 0.859443081320208 -3.07883692988303 0 0 TRUE StreptococcusStreptococcus anginosus (SP96) -0.565993149510867 0.335278106312262 -1.68813035761938 0 0 TRUE PrevotellaPrevotella melaninogenica_nov_97.865% (SPN10) 0.507570969087333 0.4718947066616 1.07560216701332 0.282105217850042 1 FALSE SelenomonasSelenomonas artemidis_nov_97.857% (SPN17) -0.797042209697515 0.281083416342148 -2.83560737972289 0 0 TRUE AbiotrophiaAbiotrophia defectiva_nov_97.491% (SPN2) -0.274170237059567 0.515049158350203 -0.532318580886112 0.594505365239082 1 FALSE FusobacteriumFusobacterium hwasookii_nov_97.802% (SPN42) 0.00457910434063974 0.329127280243534 0.0139128678037611 0.98889949570091 1 FALSE FusobacteriumFusobacterium hwasookii_nov_96.774% (SPN46) -0.10389502913757 0.559208894165092 -0.185789300244745 0.852609995616595 1 FALSE FusobacteriumFusobacterium hwasookii_nov_94.139% (SPN57) 0.031260006898485 0.366593075207627 0.0852716786338102 0.932045406682166 1 FALSE PrevotellaPrevotella pallens_nov_97.865% (SPN61) 0.763668199343892 0.596346650255709 1.2805776623654 0.200342050125973 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058_nov_97.857% (SPN63) -0.624110945225793 0.622857684817603 -1.00201211358347 0.316337742341974 1 FALSE FusobacteriumFusobacterium hwasookii_nucleatum_nucleatum_ss_polymorphum_nucle ...(4 species) (SPP17) -0.460093253326806 0.484600938623116 -0.949427078358652 0.342403443701206 1 FALSE StreptococcusStreptococcus mitis_oralis_oralis_subsp._dentisani_clade_398 (SPP20) -0.00800100498697637 0.378798686731075 -0.0211220504907838 0.983148295069684 1 FALSE StreptococcusStreptococcus oralis_oralis_subsp._tigurinus_clade_071 (SPP21) -0.10389502913757 0.241054946031949 -0.431001441156074 0 0 TRUE GranulicatellaGranulicatella adiacens_paradiacens (SPP23) -0.521482685302693 0.309891791539234 -1.68278960443736 0.0924158281715542 1 FALSE StreptococcusStreptococcus sp._HMT_423_sp._str._C300 (SPP24) 0.163153575575965 0.233469640305148 0.698821377215132 0.484663667197857 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nucleatum_subsp._animalis (SPP26) -0.0211418097089203 0.887792709047835 -0.0238139032833409 0.981001049978466 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP27) 0.127154031049079 0.874897251049101 0.145335959047313 0.8844456249032 1 FALSE FusobacteriumFusobacterium naviforme_nucleatum (SPP30) -1.50044660981305 1.02168123786374 -1.46860542623878 0.141939842224277 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_subsp._vincentii (SPP31) -0.12099279393342 0.777198028680069 -0.155678204870005 0.876286677681078 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_polymorphum_nucleatum_subsp._polymorphum (SPP32) -0.645402586664625 0.487998941957572 -1.32254915159373 0.18598535356705 1 FALSE SelenomonasSelenomonas sp._HMT_892_sp._Oral_Taxon_G51 (SPP35) -0.10389502913757 0.299495701569916 -0.346899900709646 0 0 TRUE VeillonellaVeillonella dispar_parvula_sp._Oral_Taxon_E53 (SPP38) 0.050642889624647 0.119308841491357 0.424468874155614 0.67122390052854 1 FALSE VeillonellaVeillonella dispar_parvula (SPP39) -0.386327649266638 0.748753515933115 -0.51596104865723 0.605881614304987 1 FALSE PorphyromonasPorphyromonas pasteri_sp._HMT_284 (SPP4) 1.6307738665547 0.336251815353349 4.84985892147825 0 0 TRUE Atopobium_LancefieldellaAtopobium_Lancefieldella rimae (SPP40) 0.14366795149866 0.293907443740019 0.488820390768136 0.624968860602607 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP5) -0.260562905552815 0.52050204483418 -0.500599196754019 0.616653227871099 1 FALSE FusobacteriumFusobacterium multispecies_sppn2_3_nov_96.970% (SPPN2) 0.763668199343892 0.518144628614475 1.4738514252014 0 0 TRUE