GroupPerio-Dfx_1mM...1 GroupPerio-Dfx_1mM...2 GroupPerio-Dfx_1mM...3 GroupPerio-Dfx_1mM...4 GroupPerio-Dfx_1mM...5 GroupPerio-Dfx_1mM...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas pasteri (SP10) -0.134176687615918 0.182190984369363 -0.736461730421829 0.461449749137343 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G67 (SP101) -0.173541820452594 0.31398982340684 -0.552698869567293 0.580469627556914 1 FALSE PrevotellaPrevotella oralis (SP102) -0.550163431176666 0.524409193443755 -1.0491109577309 0.294127053420105 1 FALSE SelenomonasSelenomonas sp._HMT_481 (SP104) -0.208661992338536 0.223469816786553 -0.933736803202554 0.350439675663013 1 FALSE FretibacteriumFretibacterium sp._HMT_360 (SP105) 0.523046654554563 0.167052206536782 3.13103708953043 0.00174190159812565 0.224705306158208 FALSE SelenomonasSelenomonas sp._Oral_Taxon_E83 (SP106) -0.208661992338536 0.33681995283619 -0.619506031580075 0.535583049691684 1 FALSE PrevotellaPrevotella oulorum (SP108) 0.558866371992812 0.602214523065271 0.928018755091098 0.353397840988139 1 FALSE ActinomycesActinomyces odontolyticus (SP109) -0.469581772088414 0.589071882336534 -0.797155298307287 0.425360843887752 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_129 (SP11) 0.619640224257464 0.223254965876694 2.77548238098183 0.00551198858222144 0.68899857277768 FALSE CapnocytophagaCapnocytophaga sputigena (SP111) -0.670760112711833 0.231968112216472 -2.8916048257783 0.00383279706422631 0.486765227156742 FALSE PrevotellaPrevotella baroniae (SP119) 0.113484846181339 0.557647288019309 0.203506497062727 0.838739168013038 1 FALSE PorphyromonasPorphyromonas gingivalis (SP12) 0.885809456330054 0.908257948959452 0.975284011931725 0.329419398912285 1 FALSE MegasphaeraMegasphaera micronuciformis (SP127) 1.09534567613751 0.30783246729708 3.55825259679457 0.000373330204290276 0.0492795869663165 TRUE SelenomonasSelenomonas sp._HMT_136 (SP130) 0.484485188221409 0.2162431883567 2.24046450620324 0 0 TRUE SlackiaSlackia exigua (SP135) 0.484485188221409 0.2162431883567 2.24046450620324 0 0 TRUE StreptococcusStreptococcus constellatus (SP136) -0.147888140073885 0.465350686704746 -0.31779933778784 0.750637153052294 1 FALSE PorphyromonasPorphyromonas sp._HMT_275 (SP14) 0.277626358979706 0.475539532853613 0.583813415708528 0.559345851259568 1 FALSE OribacteriumOribacterium sp._HMT_078 (SP141) -0.208661992338536 0.460057356326072 -0.453556473925056 0.65014808745599 1 FALSE StreptococcusStreptococcus pneumoniae (SP142) -0.208661992338536 0.211177112640567 -0.988089995783248 0 0 TRUE DialisterDialister pneumosintes (SP143) -0.28304317610994 0.672239868106164 -0.421044912000429 0.67372228661069 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_H27 (SP144) -0.208661992338536 0.70046081008661 -0.297892457841768 0.76578524454498 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H64 (SP149) 0.253436128034761 0.285023781015109 0.88917537733922 0 0 TRUE PorphyromonasPorphyromonas endodontalis (SP15) 1.12555445752324 1.38695315088043 0.811530264601038 0.417061220036965 1 FALSE StomatobaculumStomatobaculum longum (SP156) 0.789915432179461 0.435832235011459 1.81243003321838 0.0699197757550893 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G55 (SP158) -0.208661992338536 0.37415699495155 -0.557685664450978 0.577059048462061 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP16) 0.362035363159525 0.599829915536852 0.603563366517825 0.546133974611606 1 FALSE CapnocytophagaCapnocytophaga sp._HMT_864 (SP164) 0.253436128034761 0.285023781015109 0.88917537733922 0 0 TRUE SelenomonasSelenomonas sp._HMT_919 (SP169) -0.298549847988238 0.139253599632274 -2.14392912482419 0.0320385661352446 1 FALSE FusobacteriumFusobacterium hwasookii (SP17) -0.0795131248033742 0.199878239014991 -0.397807811371656 0.690771858836686 1 FALSE PorphyromonasPorphyromonas sp._HMT_278 (SP18) 0.189534032040426 0.333540080868229 0.568249643482291 0.569865466811965 1 FALSE SelenomonasSelenomonas sputigena (SP185) -1.07208438082048 0.539854288796987 -1.98587730628114 0.0470469491477876 1 FALSE MycoplasmaMycoplasma salivarium (SP186) 1.02096449236611 0.469497174035739 2.17459134756877 0.0296607532971831 1 FALSE PrevotellaPrevotella sp._HMT_376 (SP190) 0.84129899212188 0.4107470065212 2.04821697727567 0.0405387436546969 1 FALSE PrevotellaPrevotella sp._HMT_301 (SP191) -0.609986260447182 0.315895135514464 -1.93097706127624 0.0534858892170939 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP192) -0.439711052525185 0.405989415955386 -1.08306038345961 0.278781621840438 1 FALSE StreptococcusStreptococcus mitis (SP2) -0.574866088561239 0.358934464950179 -1.60159066541863 0 0 TRUE PrevotellaPrevotella maculosa (SP20) -0.21014677578833 0.27520434882219 -0.763602670843353 0.445104057174092 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H23 (SP200) 1.13312190457318 0.299557035401215 3.7826582942895 0.000155162355583105 0.0207917556481361 TRUE PrevotellaPrevotella intermedia (SP21) -1.25409686174372 0.339110072414509 -3.69819997623305 0.000217133799014771 0.0288787952689645 TRUE OribacteriumOribacterium sinus (SP22) 0.136590731621291 0.467081334118462 0.29243457540234 0.769954375651903 1 FALSE ParvimonasParvimonas micra (SP23) 0.0283932363490048 0.336601927899465 0.0843525660301187 0.932776119636799 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP24) -0.491094612467604 0.461307156311285 -1.06457184925226 0.287069724475276 1 FALSE PrevotellaPrevotella buccae (SP25) 0.362937483692106 0.223269086910961 1.62556083653822 0.104043112167415 1 FALSE StreptococcusStreptococcus sp._HMT_056 (SP26) -0.208661992338536 0.262643869691561 -0.794467400223662 0 0 TRUE CentipedaCentipeda sp._Oral_Taxon_D18 (SP27) -0.208661992338536 0.211177112640567 -0.988089995783248 0 0 TRUE GranulicatellaGranulicatella adiacens (SP28) -0.44929419028718 0.742156750857534 -0.605389885314709 0.544919970084266 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP29) -0.0460942568901578 0.771060694597949 -0.0597803223703323 0.952330598016987 1 FALSE GemellaGemella morbillorum (SP31) 0.240283182454578 0.199674116110309 1.20337671770053 0.228830573347914 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP32) 0.261413780058809 0.629896523738941 0.415010672716701 0.678134090158322 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP33) -0.57486608856124 0.195830420107564 -2.93553007875631 0.00332978327298305 0.42621225894183 FALSE PrevotellaPrevotella melaninogenica (SP34) 0.0892772996688292 0.534138871137107 0.16714248764328 0.867257935898179 1 FALSE CampylobacterCampylobacter showae (SP35) -0.208661992338536 0.262643869691561 -0.794467400223662 0 0 TRUE EikenellaEikenella corrodens (SP37) 0.251951344584967 0.192065748736875 1.31179737273268 0.189588511636341 1 FALSE CampylobacterCampylobacter concisus (SP38) 0.31697624790431 0.219336396272405 1.44516028024205 0.148412870260555 1 FALSE PrevotellaPrevotella denticola (SP39) 1.32452676702537 0.928279928286361 1.42686136656051 0.153619858522012 1 FALSE FusobacteriumFusobacterium nucleatum (SP4) 0.619640224257464 0.370038023290973 1.67453122451208 0.0940262430802154 1 FALSE HaemophilusHaemophilus parainfluenzae (SP40) -0.439711052525185 0.459654931773252 -0.95661119272423 0 0 TRUE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP41) 1.09199556418635 0.32828135579219 3.32640140817989 0.000879751360837787 0.11524742826975 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_071 (SP42) 0.0914739028951806 0.3893936592629 0.234913693942361 0.814275720723461 1 FALSE AlloprevotellaAlloprevotella rava (SP43) 0.0458895698500261 0.321337791035334 0.142807883573769 0.886441910711579 1 FALSE StreptococcusStreptococcus gordonii (SP44) -0.0700165230133835 0.672113229111562 -0.104173701663238 0.917031503434421 1 FALSE SelenomonasSelenomonas sp._HMT_146 (SP47) -0.208661992338536 0.262643869691561 -0.794467400223662 0 0 TRUE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP48) 0.0770445405566978 0.415866762017866 0.18526255905344 0.8530231031914 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP49) 0.253436128034761 0.856828962549598 0.295783801799405 0.767395194087665 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP52) 0.686530456078181 0.320567349460731 2.1416106700607 0.0322248243993968 1 FALSE AlloprevotellaAlloprevotella tannerae (SP53) 0.130310439067126 0.709280380040503 0.183722041006809 0.854231517004332 1 FALSE PrevotellaPrevotella marshii (SP54) 0.0564134932500428 0.34162290069938 0.165133816071907 0.868838656997562 1 FALSE StreptococcusStreptococcus cristatus_clade_578 (SP56) -0.161815778524093 0.45483585932376 -0.355767416326138 0.722014752642767 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G51 (SP61) 0.0223870678481122 0.514767563399293 0.0434896629855194 0.965311204473973 1 FALSE CampylobacterCampylobacter sp._Oral_Taxon_E65 (SP63) 2.31136482933541 0.128237744188364 18.0240602637264 1.26137040374454e-72 1.72807745313003e-70 TRUE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsps._yurii_&_margaretiae (SP64) 0.306801612955864 0.198450972757971 1.54598190521362 0.122108937932534 1 FALSE PrevotellaPrevotella sp._HMT_314 (SP65) -0.681017332267418 0.480948242763212 -1.41598881483534 0.156778779328146 1 FALSE StreptococcusStreptococcus chosunense (SP68) -0.492579395917398 0.455289014462255 -1.08190485663087 0.279294806629702 1 FALSE VeillonellaVeillonella parvula (SP7) -0.00524276012941495 0.255361588056707 -0.0205307312243481 0.983619997267199 1 FALSE SelenomonasSelenomonas dianae (SP70) 0.110514544056022 0.188273059865075 0.586990747031049 0.557209921129042 1 FALSE SolobacteriumSolobacterium moorei (SP71) -0.322955922113829 0.16861734367582 -1.91531852580204 0.0554518944106799 1 FALSE FusobacteriumFusobacterium sp._HMT_204 (SP72) 0.416870790716492 0.919759967891707 0.45323867668654 0.650376885000647 1 FALSE AlloprevotellaAlloprevotella sp._HMT_473 (SP73) -2.64640212136864 2.12594740456221 -1.24481072094707 0.213201334354266 1 FALSE SelenomonasSelenomonas infelix (SP74) -0.260045552280956 0.365245389885878 -0.711974906410749 0.476480315098726 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_D95 (SP75) 0.550915966718752 0.278472721319061 1.97834805545473 0.0478894553715434 1 FALSE ParvimonasParvimonas sp._HMT_110 (SP76) -0.070317139297098 0.938270505310233 -0.0749433547139459 0.940259781452823 1 FALSE CatonellaCatonella morbi (SP78) 1.72207839415215 1.3264995674404 1.29821255613001 0.194214304644345 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP79) 0.671023784199884 0.476489277067835 1.40826628529639 0 0 TRUE StreptococcusStreptococcus sp._Oral_Taxon_F53 (SP80) -0.339676188375072 0.337385396338332 -1.00678983756144 0.314035779257818 1 FALSE AbiotrophiaAbiotrophia defectiva (SP81) 0.542602983936335 0.274989380833433 1.97317795433345 0.0484752912515311 1 FALSE SelenomonasSelenomonas flueggei (SP82) -0.57486608856124 0.600256980702667 -0.95769996358609 0.338214075139334 1 FALSE VeillonellaVeillonella sp._Oral_Taxon_G61 (SP83) -0.28304317610994 0.504013758940294 -0.561578272595271 0.574403387295316 1 FALSE SelenomonasSelenomonas sp._HMT_149 (SP84) -0.208661992338536 0.497851527179565 -0.419124941768585 0.675124823316312 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP85) -0.135765592016927 0.587346857359217 -0.231150623036182 0.817197788330613 1 FALSE StreptococcusStreptococcus cristatus (SP87) 0.410104004450006 0.449792468590361 0.911762719672169 0.361893639254637 1 FALSE DialisterDialister invisus (SP88) 0.0819617889320087 0.203282814118607 0.40319094010666 0.686807764109626 1 FALSE FusobacteriumFusobacterium periodonticum (SP89) -0.116451246916805 0.366454344569609 -0.317778322572689 0.750653095105658 1 FALSE VeillonellaVeillonella dispar (SP9) -0.462708676354169 0.237691445525375 -1.94667786773492 0.0515733666325216 1 FALSE StreptococcusStreptococcus sanguinis (SP90) 0.152675837410449 0.22213480020702 0.687311656112244 0.491886355122125 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP91) 0.179054944263357 0.504939233321853 0.354606915936013 0.722884094290733 1 FALSE StreptococcusStreptococcus anginosus (SP96) 0.241313579977803 0.475495978167578 0.507498677292191 0.61180496423913 1 FALSE PrevotellaPrevotella sp._HMT_472 (SP98) -1.20723941685653 0.571913899960063 -2.11087615975208 0.0347829577242488 1 FALSE AlloprevotellaAlloprevotella rava_nov_97.865% (SPN1) 1.31278740481741 0.129730228240746 10.1193640265645 0 0 TRUE SelenomonasSelenomonas artemidis_nov_97.857% (SPN17) 0.584520052371522 0.347734665900628 1.68093696053462 0.0927751598627505 1 FALSE SelenomonasSelenomonas dianae_nov_97.527% (SPN22) -0.401934824089518 0.305065799294087 -1.31753485647878 0.187659405232754 1 FALSE AlloprevotellaAlloprevotella sp._HMT_473_nov_97.153% (SPN31) -0.0972612963096452 0.752163161109323 -0.129308774131134 0.897113328971563 1 FALSE FusobacteriumFusobacterium hwasookii_nov_97.802% (SPN42) 0.0223870678481123 0.27735332670799 0.0807167814204095 0.935667190719868 1 FALSE FusobacteriumFusobacterium hwasookii_nov_96.774% (SPN46) -0.112767968187943 0.490235052013568 -0.230028366443332 0.8180697274397 1 FALSE SelenomonasSelenomonas sp._HMT_481_nov_96.786% (SPN54) -0.138421648566652 0.218390407592789 -0.633826595647707 0.526193994451552 1 FALSE FusobacteriumFusobacterium hwasookii_nov_94.139% (SPN57) -0.0519941159232912 0.5640292750061 -0.0921833639268616 0.92655235542333 1 FALSE PorphyromonasPorphyromonas pasteri_nov_97.865% (SPN62) 0.388591164070815 0.813281553206481 0.477806440510962 0.632787976716177 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058_nov_97.857% (SPN63) -0.208661992338536 0.211177112640567 -0.988089995783248 0 0 TRUE PorphyromonasPorphyromonas endodontalis_nov_97.865% (SPN64) 0.359587371740939 0.859533346030444 0.418351857320731 0.675689879966937 1 FALSE PorphyromonasPorphyromonas sp._HMT_278_nov_97.865% (SPN65) 0.253436128034761 0.286758682359857 0.883795831216438 0.376806437194035 1 FALSE BacteroidesBacteroides heparinolyticus_nov_95.745% (SPN7) 0.148960043485158 0.285803047242529 0.521198233966875 0.602228684291354 1 FALSE SelenomonasSelenomonas noxia_sp._HMT_937 (SPP11) 0.0575072397340542 0.366775420204158 0.156791422124318 0.875409233389644 1 FALSE Bacteroidaceae_[G-1]_PhocaeicolaBacteroidaceae_[G-1]_Phocaeicola abscessus_bacterium_HMT_272 (SPP15) 0.985844320480167 0.30432494792974 3.23944627999335 0.00119762024086251 0.155690631312126 FALSE FusobacteriumFusobacterium hwasookii_nucleatum_nucleatum_ss_polymorphum_nucle ...(4 species) (SPP17) -1.74036860905007 0.383740328796406 -4.53527679644383 5.75279885463812e-06 0.000776627845376147 TRUE StreptococcusStreptococcus mitis_oralis_oralis_subsp._dentisani_clade_398 (SPP20) 0.249958937544228 0.276485654067737 0.904057530171128 0.365964896585602 1 FALSE StreptococcusStreptococcus oralis_oralis_subsp._tigurinus_clade_071 (SPP21) -1.34926754862683 0.467844568974221 -2.88400814737508 0.00392648594575868 0.494737229165594 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP23) -0.26594541131409 0.432016451492999 -0.615590935009565 0.538164535643827 1 FALSE StreptococcusStreptococcus sp._HMT_423_sp._str._C300 (SPP24) -0.0776477963020007 0.35628600981081 -0.217936697383184 0.827478433918253 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nucleatum_subsp._animalis (SPP26) 0.568080164628956 0.269159713384657 2.11056906505585 0.0348093689686688 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP27) -0.84103532063383 0.492028756288886 -1.709321477422 0.0873914170761632 1 FALSE FusobacteriumFusobacterium naviforme_nucleatum (SPP30) -0.147888140073885 0.467848822850929 -0.316102409262674 0.751924778106514 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_subsp._vincentii (SPP31) -0.0734481967171729 0.264260116327766 -0.277939016064286 0.781059172907411 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_polymorphum_nucleatum_subsp._polymorphum (SPP32) 0.188797394814927 0.18878111117438 1.00008625672582 0.317268766458347 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP33) 0.410104004450006 0.596591072097872 0.687412238684536 0.491822987411931 1 FALSE StreptococcusStreptococcus cristatus_cristatus_clade_578 (SPP34) 1.40933183567842 0.790843005143274 1.78206271853299 0.0747390045652707 1 FALSE SelenomonasSelenomonas sp._HMT_892_sp._Oral_Taxon_G51 (SPP35) -0.0572435682460043 0.267913748439912 -0.213664168335292 0.830808955568836 1 FALSE Eubacterium_[XI][G-7]_PeptoanaerobacterEubacterium_[XI][G-7]_Peptoanaerobacter [Eubacterium] yurii_yurii (SPP36) 0.349005617588309 0.187756626484233 1.85881917524555 0.0630527735366667 1 FALSE VeillonellaVeillonella dispar_parvula_sp._Oral_Taxon_E53 (SPP38) -0.380734149805493 0.315307792098674 -1.20749997096914 0.227239656239987 1 FALSE VeillonellaVeillonella dispar_parvula (SPP39) -0.75174217224863 0.344505984978856 -2.18208740929354 0.0291030822595444 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella rimae (SPP40) -0.29467226244342 0.251984650772174 -1.16940560284301 0.242240253538436 1 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP5) -0.761404684539714 0.291577524134019 -2.61132845133066 0.00901912250374851 1 FALSE CapnocytophagaCapnocytophaga ochracea_sp._HMT_335 (SPP6) -0.378937200260533 0.488421627687445 -0.775840337076609 0.437843263827766 1 FALSE PorphyromonasPorphyromonas gingivalis_sp._Oral_Taxon_F92 (SPP8) 1.95715062285672 1.9493823371365 1.0039849985158 0.315385844443286 1 FALSE StreptococcusStreptococcus multispecies_sppn1_2_nov_97.509% (SPPN1) -0.626249648503659 0.437478213726113 -1.43149905264935 0.152287238294517 1 FALSE FusobacteriumFusobacterium multispecies_sppn2_3_nov_96.970% (SPPN2) 0.324467199854997 0.249053665560156 1.30280033873513 0.192642935102897 1 FALSE PorphyromonasPorphyromonas multispecies_sppn3_2_nov_97.865% (SPPN3) 0.0223870678481121 0.561930555142639 0.0398395631688499 0.968221034407667 1 FALSE multigenusmultigenus multispecies_sppn7_2_nov_96.071% (SPPN7) -0.558602700504762 0.512954611062442 -1.08899050414572 0.276158073204361 1 FALSE FusobacteriumFusobacterium multispecies_sppn9_3_nov_96.337% (SPPN9) 0.484485188221409 0.840550191018702 0.576390551567467 0.564351229357569 1 FALSE