GroupPerio-Dfx_2mM...1 GroupPerio-Dfx_2mM...2 GroupPerio-Dfx_2mM...3 GroupPerio-Dfx_2mM...4 GroupPerio-Dfx_2mM...5 GroupPerio-Dfx_2mM...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance PorphyromonasPorphyromonas pasteri (SP10) -0.39991304193172 0.125348516321822 -3.1904090584126 0.00142071546450783 0.177589433063478 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G67 (SP101) 0.075819143650531 0.409206385089901 0.185283383674167 0.853006770289645 1 FALSE PrevotellaPrevotella oralis (SP102) -1.10610705984056 0.546094811187272 -2.02548538675135 0.0428175475071979 1 FALSE SelenomonasSelenomonas sp._HMT_481 (SP104) -0.668711596851834 0.217228633896272 -3.07837684589569 0 0 TRUE FretibacteriumFretibacterium sp._HMT_360 (SP105) 0.0326418342687085 0.157040134282279 0.207856637527034 0.835340907884019 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_E83 (SP106) 0.120329607858705 0.463480896345999 0.259621505022887 0.795155746391593 1 FALSE PrevotellaPrevotella oulorum (SP108) 0.210974179686585 0.605048102503839 0.348689928641247 0.727322106071213 1 FALSE ActinomycesActinomyces odontolyticus (SP109) 0.264874936216992 0.537323547474555 0.492952407282197 0.622046215898685 1 FALSE Veillonellaceae_[G-1]Veillonellaceae_[G-1] bacterium_HMT_129 (SP11) 0.390639679930815 0.432046504434712 0.90416118617121 0.365909938022309 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F29 (SP110) 0.0244355837081114 0.126890354173283 0.192572428907732 0 0 TRUE CapnocytophagaCapnocytophaga sputigena (SP111) -0.594330413080431 0.144990740183514 -4.09909220635878 4.14773781011367e-05 0.00535058177504664 TRUE PrevotellaPrevotella baroniae (SP119) 0.106722276351953 0.4323430670365 0.246846276692909 0.805027194793223 1 FALSE PorphyromonasPorphyromonas gingivalis (SP12) 1.21996911870595 0.768876867046185 1.58668984722188 0.112582906916208 1 FALSE MegasphaeraMegasphaera micronuciformis (SP127) 0.987892836340166 0.406932420088025 2.42765822424881 0.0151966565354535 1 FALSE SelenomonasSelenomonas sp._HMT_136 (SP130) 0.0244355837081114 0.313029247750669 0.0780616631950464 0 0 TRUE SlackiaSlackia exigua (SP135) 0.927118984075515 0.133776630803607 6.93035082813969 0 0 TRUE StreptococcusStreptococcus constellatus (SP136) -0.19035008842206 0.517086011966521 -0.368120745904811 0.712783202402085 1 FALSE PorphyromonasPorphyromonas sp._HMT_275 (SP14) 0.285457754284575 0.45701727749287 0.624610421405849 0.532226778199448 1 FALSE OribacteriumOribacterium sp._HMT_078 (SP141) 0.525794715966869 0.477574484067775 1.10096902893215 0.27091013677751 1 FALSE StreptococcusStreptococcus pneumoniae (SP142) -0.437662536665186 0.206614462211236 -2.11825702799901 0 0 TRUE DialisterDialister pneumosintes (SP143) -0.302507500629131 0.976653760027542 -0.309738735476327 0.75675964371456 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_H27 (SP144) 0.159590619744166 0.682056228299995 0.233984550132972 0.814996972978931 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H64 (SP149) 0.25548464389476 0.321533464554288 0.79458181514299 0 0 TRUE PorphyromonasPorphyromonas endodontalis (SP15) 0.718938730906321 1.30068776174492 0.552737368683963 0.580443261030017 1 FALSE StomatobaculumStomatobaculum longum (SP156) 0.390639679930815 0.338865240128953 1.15278769749933 0.248997535191341 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G55 (SP158) -0.206613476478537 0.282297554257345 -0.731899633427877 0.464229829947424 1 FALSE AlloprevotellaAlloprevotella sp._HMT_308 (SP16) -0.908893648434522 0.799887418359912 -1.13627696544861 0.255840667972617 1 FALSE SelenomonasSelenomonas sp._HMT_919 (SP169) -0.69539249940968 0.467650275891252 -1.48699259951124 0.13701676552764 1 FALSE FusobacteriumFusobacterium hwasookii (SP17) 0.0960273509226752 0.160408349930446 0.598643094105221 0.549410912296901 1 FALSE PorphyromonasPorphyromonas sp._HMT_278 (SP18) -0.20403961912788 0.271545795763004 -0.751400398428406 0.452411723024743 1 FALSE SelenomonasSelenomonas sputigena (SP185) -0.568676732701722 0.387839682026426 -1.46626753026002 0.142575417573647 1 FALSE MycoplasmaMycoplasma salivarium (SP186) 0.390639679930814 0.478316453376444 0.816697140926854 0.414101525620409 1 FALSE PrevotellaPrevotella pallens (SP19) 0.159590619744166 0.226027645118317 0.706066816121658 0 0 TRUE PrevotellaPrevotella sp._HMT_376 (SP190) -0.341768512514592 0.386746793888201 -0.883700958652002 0.376857662701394 1 FALSE PrevotellaPrevotella sp._HMT_301 (SP191) -0.974141840809886 0.530821306375402 -1.8351596462124 0.0664820383511676 1 FALSE StreptococcusStreptococcus sp._str._2136FAA (SP192) -1.03491569307454 0.154253026771695 -6.70920833603013 0 0 TRUE StreptococcusStreptococcus mitis (SP2) -0.803866632887889 0.348635852331944 -2.30574861280334 0 0 TRUE PrevotellaPrevotella maculosa (SP20) -0.624818988860101 0.191264969729702 -3.26677169239669 0.00108781369770522 0.137064525910858 FALSE SelenomonasSelenomonas sp._Oral_Taxon_H23 (SP200) 0.329865827666163 0.490073737857992 0.673094275787837 0.500887315381357 1 FALSE PrevotellaPrevotella intermedia (SP21) -1.04467425516811 0.370833759108041 -2.81709588059309 0.00484600565421678 0.562136655889147 FALSE OribacteriumOribacterium sinus (SP22) -0.100253311842089 0.330988464259055 -0.302890652296642 0.761973195333301 1 FALSE ParvimonasParvimonas micra (SP23) -0.456359025548867 0.3264523540795 -1.3979345526108 0.162132721542967 1 FALSE StreptococcusStreptococcus sp._HMT_064 (SP24) -1.25657446093895 0.438766391222302 -2.86388038390641 0.00418486010711112 0.493813492639112 FALSE PrevotellaPrevotella buccae (SP25) -0.328161181007841 0.170012810894659 -1.93021443078881 0.0535802742368036 1 FALSE StreptococcusStreptococcus sp._HMT_056 (SP26) -0.437662536665186 0.255176475826417 -1.71513669215694 0 0 TRUE CentipedaCentipeda sp._Oral_Taxon_D18 (SP27) -0.437662536665186 0.206614462211236 -2.11825702799901 0 0 TRUE GranulicatellaGranulicatella adiacens (SP28) -0.653045473483611 0.661763705592542 -0.986825762677442 0.323728062711721 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP29) -0.257997036420957 0.365048441331478 -0.706747399002549 0.47972346817632 1 FALSE GemellaGemella morbillorum (SP31) 0.502631707201061 0.302488088418233 1.6616578518163 0.0965813965997648 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] bacterium_HMT_274 (SP32) -1.30222332986149 0.280937403869336 -4.63527928971379 3.56455875010792e-06 0.000474086313764353 TRUE CapnocytophagaCapnocytophaga gingivalis (SP33) -0.0423444370574327 0.213284021776155 -0.198535439761512 0.842626159643272 1 FALSE PrevotellaPrevotella melaninogenica (SP34) -0.505927340880524 0.642039812825635 -0.787999950741253 0.43069673469681 1 FALSE CampylobacterCampylobacter showae (SP35) -0.206613476478537 0.330078244386673 -0.625953027781188 0.531345751400679 1 FALSE EikenellaEikenella corrodens (SP37) 0.158105836294373 0.114216185816975 1.3842682205106 0.166276341071467 1 FALSE CampylobacterCampylobacter concisus (SP38) 0.215389255269925 0.290083985441284 0.74250653631316 0.457780493057039 1 FALSE PrevotellaPrevotella denticola (SP39) 0.985569946568135 0.919345627047645 1.0720341921168 0.28370467480125 1 FALSE FusobacteriumFusobacterium nucleatum (SP4) -0.57281757270124 0.354333518831959 -1.61660566177736 0 0 TRUE HaemophilusHaemophilus parainfluenzae (SP40) -0.437662536665186 0.493139267758953 -0.887502913029258 0.37480819855418 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058 (SP41) 0.265741863450344 0.354159355611937 0.750345456754008 0.45304667178929 1 FALSE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_071 (SP42) -0.552253049699461 0.341973143599925 -1.61490181330012 0.10633195952461 1 FALSE AlloprevotellaAlloprevotella rava (SP43) 0.114620575652635 0.331049986309255 0.346233440244158 0.729167285389893 1 FALSE StreptococcusStreptococcus gordonii (SP44) -0.308407359662264 0.597179360672522 -0.516440084792862 0.60554707540622 1 FALSE SelenomonasSelenomonas sp._HMT_146 (SP47) -0.437662536665186 0.255176475826417 -1.71513669215694 0 0 TRUE StreptococcusStreptococcus oralis_subsp._tigurinus_clade_070 (SP48) -0.184343919921167 0.415568744692102 -0.443594284401126 0.657335938803 1 FALSE AnaeroglobusAnaeroglobus geminatus (SP49) 0.779841399982502 0.731317075345908 1.06635196452051 0.286264567284558 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP52) -0.110719452327944 0.403960424428184 -0.274084899491502 0.784019378112324 1 FALSE AlloprevotellaAlloprevotella tannerae (SP53) 0.0816388841077865 0.400847636251599 0.20366562435345 0.838614806909759 1 FALSE PrevotellaPrevotella marshii (SP54) -0.577214257987298 0.388566129773283 -1.48549812698314 0.1374119191946 1 FALSE StreptococcusStreptococcus cristatus_clade_578 (SP56) 0.0447808805702338 0.360822423457627 0.124107809434667 0.901229914932963 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_G51 (SP61) -0.803866632887889 0.423191479587118 -1.89953406829498 0.0574942916796011 1 FALSE CampylobacterCampylobacter sp._Oral_Taxon_E65 (SP63) 3.2256798833248 0.199594041326221 16.1612033199563 9.4695038000509e-59 1.30679152440702e-56 TRUE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsps._yurii_&_margaretiae (SP64) -0.463929103143165 0.121619570312794 -3.81459251952611 0.000136407825880686 0.0174602017127277 TRUE PrevotellaPrevotella sp._HMT_314 (SP65) -0.543813780371364 0.68908354243854 -0.789184107411574 0.430004409307618 1 FALSE StreptococcusStreptococcus chosunense (SP68) -0.360625296344057 0.450573544470361 -0.800369441947517 0.423496780377069 1 FALSE VeillonellaVeillonella parvula (SP7) -0.539536462949429 0.217312607075345 -2.48276650954892 0.0130366507628305 1 FALSE SelenomonasSelenomonas dianae (SP70) -0.143974295712512 0.160351193817444 -0.897868561405433 0.369255627221654 1 FALSE SolobacteriumSolobacterium moorei (SP71) -0.574104832909863 0.195496429541785 -2.93665124348042 0.00331776992675418 0.394814621283747 FALSE FusobacteriumFusobacterium sp._HMT_204 (SP72) -0.0714584404424826 0.773565735658911 -0.0923753950678999 0.926399787719712 1 FALSE AlloprevotellaAlloprevotella sp._HMT_473 (SP73) -0.376426042642252 1.89194514600699 -0.198962450595733 0.842292117402538 1 FALSE SelenomonasSelenomonas infelix (SP74) 0.278482267723744 0.289997705974431 0.960291278125824 0.336908638445976 1 FALSE FusobacteriumFusobacterium sp._Oral_Taxon_D95 (SP75) 0.0216693161032127 0.320393094591216 0.0676335304007103 0.9460773631007 1 FALSE ParvimonasParvimonas sp._HMT_110 (SP76) -2.76639477176142 0.980251830657282 -2.82212660588095 0.00477063397177736 0.558164174697951 FALSE CatonellaCatonella morbi (SP78) 1.48218864125253 1.36641089655812 1.08473128030964 0.278040689451818 1 FALSE SchaaliaSchaalia sp._HMT_180 (SP79) 0.25548464389476 0.430622152819498 0.593291920125276 0 0 TRUE StreptococcusStreptococcus sp._Oral_Taxon_F53 (SP80) 0.0636965955935725 0.392085433006275 0.162455909430721 0.870946846162429 1 FALSE AbiotrophiaAbiotrophia defectiva (SP81) 0.366885339923651 0.296380911023197 1.2378845137396 0.215758885297865 1 FALSE SelenomonasSelenomonas flueggei (SP82) -0.960534509303135 0.463481717349174 -2.07243236000072 0.0382251381392129 1 FALSE VeillonellaVeillonella sp._Oral_Taxon_G61 (SP83) -0.838986804773831 0.465846135013724 -1.80099552559154 0.0717035852030138 1 FALSE SelenomonasSelenomonas sp._HMT_149 (SP84) -0.437662536665186 0.475396444743202 -0.920626440320985 0.357245493016228 1 FALSE PrevotellaPrevotella sp._HMT_317 (SP85) -0.537697400815299 0.579909675450755 -0.927208880240452 0.353818093049153 1 FALSE StreptococcusStreptococcus cristatus (SP87) -0.376888684400534 0.461212796153373 -0.817168750615503 0.413831998063261 1 FALSE DialisterDialister invisus (SP88) 0.0092555028557996 0.185012171910443 0.05002645372046 0.960101307689354 1 FALSE FusobacteriumFusobacterium periodonticum (SP89) -0.127143135330204 0.209328995497326 -0.607384251895619 0.543595937059072 1 FALSE VeillonellaVeillonella dispar (SP9) -0.595815196530224 0.199193969886418 -2.99113068969891 0.00277946511729716 0.336315279192956 FALSE StreptococcusStreptococcus sanguinis (SP90) -0.24265509562253 0.190886592002963 -1.27120031363315 0.20365739504093 1 FALSE LeptotrichiaLeptotrichia sp._HMT_215 (SP91) -0.512043720436589 0.591021400322933 -0.866370862640183 0.386286817245248 1 FALSE StreptococcusStreptococcus anginosus (SP96) -0.393152072457012 0.361857357626656 -1.08648356644068 0.277265107613865 1 FALSE PrevotellaPrevotella sp._HMT_472 (SP98) -1.80244405740589 0.430669670521289 -4.18521242794781 0 0 TRUE AlloprevotellaAlloprevotella rava_nov_97.865% (SPN1) 1.08378686049076 0.249689104572854 4.34054526465945 0 0 TRUE SelenomonasSelenomonas artemidis_nov_97.857% (SPN17) -0.0499456000632922 0.264262884030833 -0.188999678280454 0.850093068941067 1 FALSE SelenomonasSelenomonas dianae_nov_97.527% (SPN22) -0.223711241274387 0.151091960266688 -1.48062968327052 0.13870528099896 1 FALSE AlloprevotellaAlloprevotella sp._HMT_473_nov_97.153% (SPN31) -0.768746461001947 0.823490051893176 -0.933522462396024 0.350550278285872 1 FALSE FusobacteriumFusobacterium hwasookii_nov_97.802% (SPN42) -0.533556560815779 0.328923282413555 -1.6221307196641 0.104775361817577 1 FALSE FusobacteriumFusobacterium hwasookii_nov_96.774% (SPN46) -0.402542364779244 0.309617559948348 -1.30012769574955 0.1935572067222 1 FALSE SelenomonasSelenomonas sp._HMT_481_nov_96.786% (SPN54) -0.599956036529744 0.119654626549163 -5.01406467791898 5.32920595769536e-07 7.14113598331178e-05 TRUE FusobacteriumFusobacterium hwasookii_nov_94.139% (SPN57) -0.28099466024994 0.628816119444709 -0.44686300424054 0.654973977252223 1 FALSE PorphyromonasPorphyromonas pasteri_nov_97.865% (SPN62) 0.486533704081408 0.847610359375625 0.574006321064555 0.565963523826257 1 FALSE StreptococcusStreptococcus oralis_subsp._dentisani_clade_058_nov_97.857% (SPN63) -0.437662536665186 0.206614462211236 -2.11825702799901 0 0 TRUE PorphyromonasPorphyromonas endodontalis_nov_97.865% (SPN64) 0.756843776153518 0.534578816116884 1.41577584695769 0.156841143354411 1 FALSE PorphyromonasPorphyromonas sp._HMT_278_nov_97.865% (SPN65) -0.0714584404424823 0.224016350489382 -0.318987610888115 0.749735907504884 1 FALSE BacteroidesBacteroides heparinolyticus_nov_95.745% (SPN7) 0.0872144545493499 0.272108068340207 0.320514033565182 0.748578693791876 1 FALSE SelenomonasSelenomonas noxia_sp._HMT_937 (SPP11) -0.267387328743189 0.323276649574614 -0.827116122042939 0.408171247133588 1 FALSE Bacteroidaceae_[G-1]_PhocaeicolaBacteroidaceae_[G-1]_Phocaeicola abscessus_bacterium_HMT_272 (SPP15) 1.23254922803357 0.294139952121321 4.19034959088179 2.78524993828359e-05 0.00364867741915151 TRUE FusobacteriumFusobacterium hwasookii_nucleatum_nucleatum_ss_polymorphum_nucle ...(4 species) (SPP17) -0.949278888479529 0.183540952353393 -5.17202769358944 2.31567253322834e-07 3.12615791985825e-05 TRUE StreptococcusStreptococcus mitis_oralis_oralis_subsp._dentisani_clade_398 (SPP20) -0.198643545016998 0.273621775008572 -0.725978570275609 0.467851907877393 1 FALSE StreptococcusStreptococcus oralis_oralis_subsp._tigurinus_clade_071 (SPP21) -1.21206399673078 0.436641638247646 -2.77587818146502 0.00550528314694185 0.627602278751371 FALSE GranulicatellaGranulicatella adiacens_paradiacens (SPP23) -0.805625651921504 0.587254251366715 -1.37185154478929 0.170109657313133 1 FALSE StreptococcusStreptococcus sp._HMT_423_sp._str._C300 (SPP24) -0.672852436851353 0.369066586055452 -1.82311935643574 0.068285315533081 1 FALSE FusobacteriumFusobacterium nucleatum_ss_animalis_nucleatum_subsp._animalis (SPP26) 0.792049079781292 0.255258479441781 3.10292955404814 0.00191615245915094 0.237602904934717 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_animalis (SPP27) -1.30108492514713 0.513575305791642 -2.53338684799417 0.0112966205446314 1 FALSE FusobacteriumFusobacterium naviforme_nucleatum (SPP30) -0.607937744587183 0.479412873370239 -1.26808806846054 0.204766501938419 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_subsp._vincentii (SPP31) -0.397291198488636 0.269251096230831 -1.47554161914362 0.140066987588955 1 FALSE FusobacteriumFusobacterium nucleatum_nucleatum_ss_polymorphum_nucleatum_subsp._polymorphum (SPP32) -0.222639779021331 0.156795161493188 -1.41994036615093 0.155625042886895 1 FALSE FusobacteriumFusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP33) 0.394322958659676 0.704367297935427 0.559825761098615 0.575598290382877 1 FALSE StreptococcusStreptococcus cristatus_cristatus_clade_578 (SPP34) 0.665745997820291 0.78976099439075 0.842971484472807 0.399244391977463 1 FALSE SelenomonasSelenomonas sp._HMT_892_sp._Oral_Taxon_G51 (SPP35) 0.0673798743224341 0.253678247768747 0.265611556824759 0.790538384169575 1 FALSE Eubacterium_[XI][G-7]_PeptoanaerobacterEubacterium_[XI][G-7]_Peptoanaerobacter [Eubacterium] yurii_yurii (SPP36) -0.520050474850051 0.140582991012906 -3.6992417866704 0.000216244519408156 0.0274630539648358 TRUE VeillonellaVeillonella dispar_parvula_sp._Oral_Taxon_E53 (SPP38) -0.624313158634745 0.210066791943438 -2.9719745460903 0.00295891213992694 0.355069456791233 FALSE VeillonellaVeillonella dispar_parvula (SPP39) -1.02844299778884 0.336241046128696 -3.05864798373011 0.0022233823709491 0.271252649255791 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella rimae (SPP40) -0.741193440251692 0.263389753364431 -2.81405571319307 0.00489207490148009 0.56258861367021 FALSE Atopobium_LancefieldellaAtopobium_Lancefieldella parvula_parvulum (SPP5) -0.245874488363999 0.210439757426523 -1.16838420349277 0.242651823859058 1 FALSE CapnocytophagaCapnocytophaga ochracea_sp._HMT_335 (SPP6) -0.28099466024994 0.440911617464053 -0.637303824893772 0.523926960014923 1 FALSE PorphyromonasPorphyromonas gingivalis_sp._Oral_Taxon_F92 (SPP8) 2.68632272285412 1.62660225888242 1.65149329418723 0.0986378889084966 1 FALSE StreptococcusStreptococcus multispecies_sppn1_2_nov_97.509% (SPPN1) -0.318770888685608 0.607771877545307 -0.524491014577826 0.599937067830063 1 FALSE FusobacteriumFusobacterium multispecies_sppn2_3_nov_96.970% (SPPN2) 0.111890338530608 0.312308363354159 0.35826878706967 0.720142174183316 1 FALSE PorphyromonasPorphyromonas multispecies_sppn3_2_nov_97.865% (SPPN3) 0.412152520310005 0.433994672050543 0.949671843579696 0.342279020828532 1 FALSE multigenusmultigenus multispecies_sppn7_2_nov_96.071% (SPPN7) -0.19035008842206 0.627008912229143 -0.303584342597822 0.761444581723762 1 FALSE FusobacteriumFusobacterium multispecies_sppn9_3_nov_96.337% (SPPN9) -0.110719452327944 0.762899960286266 -0.145129713057526 0.884608459010977 1 FALSE