GroupMetronidazole...1 GroupMetronidazole...2 GroupMetronidazole...3 GroupMetronidazole...4 GroupMetronidazole...5 GroupMetronidazole...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance StreptococcusStreptococcus constellatus (SP1) 0.26630207133734 0.740557653106448 0.359596677207064 0.71914876879279 1 FALSE EikenellaEikenella corrodens (SP10) 1.42213485684842 0.464538431950993 3.06139332945106 0.00220309476092202 0.266574466071565 FALSE LachnoanaerobaculumLachnoanaerobaculum saburreum (SP104) -1.90608518746698 0.405758162406658 -4.69758926391398 0 0 TRUE CampylobacterCampylobacter concisus (SP109) -3.89937895591352 0.491011333772847 -7.94152535329757 0 0 TRUE StreptococcusStreptococcus sanguinis (SP11) 1.05817632037194 0.965412341363323 1.0960874178153 0.273040520332244 1 FALSE StreptococcusStreptococcus sp._oral_taxon_064 (SP112) 1.12888953982887 1.30775343734787 0.863228118993333 0.388012056354998 1 FALSE SlackiaSlackia exigua (SP113) -1.16738550747293 0.510196259229239 -2.28811067575548 0 0 TRUE SelenomonasSelenomonas sp._oral_taxon_126 (SP114) 0.0487841141756 0.408232564964485 0.119500790388547 0 0 TRUE FusobacteriumFusobacterium periodonticum (SP116) -1.26302558676292 0.49751461172701 -2.53867033649244 0 0 TRUE GemellaGemella sanguinis (SP119) 3.96395991737294 0.989721170406499 4.00512794501997 6.19839224579784e-05 0.00818187776445315 TRUE NeisseriaNeisseria flavescens|subflava (SP12) 1.49667496154574 0.813048765820862 1.84081819500049 0.0656482055329369 1 FALSE ActinomycesActinomyces sp._Oral_Taxon_F78 (SP127) 1.42355485963689 1.14609491987253 1.24209158853546 0.214202771677836 1 FALSE SelenomonasSelenomonas artemidis (SP128) -0.407692362959705 0.441061104739427 -0.924344401668707 0 0 TRUE StreptococcusStreptococcus gordonii (SP13) -0.00564421855817809 1.16857437351076 -0.00483000370889627 0.996146229596117 1 FALSE StreptococcusStreptococcus mitis (SP132) 1.97790350297896 0.692501747403409 2.8561711366004 0.00428783946798504 0.50167721775425 FALSE TM7_[G-1]TM7_[G-1] sp._oral_taxon_346 (SP136) 0.647930568886398 0.29748860744848 2.17800128362431 0.0294059411874633 1 FALSE StomatobaculumStomatobaculum longum (SP14) -4.48156703764334 0.891806879692857 -5.02526627646876 0 0 TRUE CampylobacterCampylobacter showae (SP148) -2.96422954199602 1.02870297626897 -2.88152130437791 0 0 TRUE AtopobiumAtopobium sp._oral_taxon_199 (SP149) -0.457955248615886 0.524507255033489 -0.873115184244013 0 0 TRUE StomatobaculumStomatobaculum sp._oral_taxon_097 (SP15) -2.86133437737174 0.767815987955034 -3.7265886908561 0 0 TRUE ActinomycesActinomyces oris (SP150) 1.91724853958208 0.897429176446574 2.13637865794997 0.0326485621905407 1 FALSE MegasphaeraMegasphaera micronuciformis (SP153) -1.50625425475215 1.10981263106326 -1.3572149141149 0 0 TRUE CampylobacterCampylobacter gracilis (SP156) -2.94904134252603 0.531142346727489 -5.55226176315233 0 0 TRUE FusobacteriumFusobacterium sp._oral_taxon_370 (SP158) -1.46298182244843 0.948843992094965 -1.5418570751745 0 0 TRUE MogibacteriumMogibacterium timidum (SP16) -2.23264885968261 0.704594301460209 -3.16870127257011 0 0 TRUE StreptococcusStreptococcus parasanguinis_I (SP160) 2.15278884032045 0.775908683383948 2.7745389198785 0.00552800191988403 0.641248222706548 FALSE ActinomycesActinomyces timonensis (SP161) 1.75681253905596 1.42118498451233 1.23616035787121 0.216398962833038 1 FALSE StomatobaculumStomatobaculum sp._oral_taxon_373 (SP162) -0.461104920009514 0.571423371404988 -0.806940953212627 0 0 TRUE SolobacteriumSolobacterium moorei (SP163) -2.1434714551612 0.526083600876419 -4.07439321733337 0 0 TRUE ActinomycesActinomyces odontolyticus (SP164) 1.3476397717268 1.4756417633626 0.913256730180831 0.361107533734993 1 FALSE PrevotellaPrevotella denticola (SP168) -0.508218134272068 0.52715800458091 -0.964071739128956 0.335009960291113 1 FALSE DialisterDialister pneumosintes (SP169) -4.83522029141605 0.244156256109799 -19.8037943751956 2.76093288869147e-87 4.19661799081103e-85 TRUE StreptococcusStreptococcus parasanguinis_II (SP17) 2.15490103027733 0.991630055004335 2.17308967129673 0.0297735689386585 1 FALSE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP171) -0.995070717665917 0.460871948903217 -2.15910454093374 0 0 TRUE SelenomonasSelenomonas sp._Oral_Taxon_G55 (SP173) -1.35676750009977 0.859187324008418 -1.57912886071219 0 0 TRUE OribacteriumOribacterium sp._oral_taxon_078 (SP175) -2.72193385596726 0.813528443846101 -3.34583735400674 0 0 TRUE StreptococcusStreptococcus salivarius (SP177) 0.367947117856492 1.23848989336244 0.29709335524534 0.766395237221839 1 FALSE FusobacteriumFusobacterium canifelinum (SP179) -0.651725861008889 0.824219838342672 -0.790718483941576 0 0 TRUE StreptococcusStreptococcus dentisani (SP18) 0.502735870138326 1.83258115514853 0.27433211823985 0.783829404143351 1 FALSE OribacteriumOribacterium sinus (SP182) -2.81734685439926 0.384252892374826 -7.33201209491751 0 0 TRUE FusobacteriumFusobacterium nucleatum_subsp._nucleatum (SP183) -0.79275053533022 0.834637710206404 -0.949813943985559 0 0 TRUE SelenomonasSelenomonas sp._oral_taxon_149 (SP184) -1.17065088613042 0.686620905494285 -1.70494500933916 0 0 TRUE FusobacteriumFusobacterium sp._HOT_204 (SP185) -0.72039252640912 0.59350836495924 -1.21378664386406 0 0 TRUE LeptotrichiaLeptotrichia wadei (SP187) -0.565754548762424 0.353291063305831 -1.60138369611877 0 0 TRUE StreptococcusStreptococcus tigurinus (SP19) 2.04813193686656 1.50125726288245 1.36427778736211 0.172480154145716 1 FALSE SelenomonasSelenomonas flueggei (SP194) -0.238232790882264 0.301675677139796 -0.789698371247436 0 0 TRUE PrevotellaPrevotella saccharolytica (SP199) -1.42147320340375 0.715602215026884 -1.98640134638257 0 0 TRUE ActinomycesActinomyces lingnae_[NVP] (SP2) 1.56390104448716 0.807032580086058 1.93784127565258 0.0526425902957202 1 FALSE StreptococcusStreptococcus anginosus (SP20) 0.935837153865226 0.602265364278963 1.55386181801375 0.120217381074205 1 FALSE EikenellaEikenella sp._oral_taxon_011 (SP202) 0.871776884060568 1.01187800742973 0.861543464389517 0.388938793368576 1 FALSE StreptococcusStreptococcus oralis (SP21) 2.16046681823078 1.22920502954469 1.7576130639744 0.0788133689809815 1 FALSE Lachnospiraceae_[G-8]Lachnospiraceae_[G-8] sp._oral_taxon_500 (SP211) -0.529290237403633 0.559943230814198 -0.94525696227099 0 0 TRUE VeillonellaVeillonella sp._oral_taxon_780 (SP214) -0.814713508531662 0.944733457779717 -0.862373933962683 0 0 TRUE VeillonellaVeillonella atypica (SP22) -4.76942955892954 0.962058474312797 -4.95752564555534 7.13966204256394e-07 0.000100669234800152 TRUE LeptotrichiaLeptotrichia sp._oral_taxon_215 (SP227) -0.403568505519158 0.409914513376713 -0.984518704143263 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_169 (SP23) 1.2439180791843 0.896914123635312 1.38688648824319 0.165476378600778 1 FALSE PrevotellaPrevotella oralis (SP232) -0.581763090297131 0.626827023895164 -0.928107864083458 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_175 (SP233) 1.23148471530325 0.791626283872997 1.55563899328641 0.11979396095353 1 FALSE AlloprevotellaAlloprevotella rava (SP235) 0.232042260550431 0.239995124939845 0.966862391928141 0 0 TRUE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP236) -1.40480469426853 0.740795704177353 -1.89634562720441 0 0 TRUE PropionibacteriumPropionibacterium propionicum (SP237) 3.98586726630135 0.601638122913705 6.62502443661313 0 0 TRUE AnaeroglobusAnaeroglobus geminatus (SP25) -2.97121317707988 1.08464012732949 -2.73935391307656 0 0 TRUE PyramidobacterPyramidobacter piscolens (SP252) -0.473229844372801 0.689145983765607 -0.686690273934408 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_897 (SP257) 1.28354133495599 0.384328767103391 3.33969623098937 0 0 TRUE AtopobiumAtopobium parvulum (SP259) -1.8897691900685 0.483143013244261 -3.91140746790245 0 0 TRUE SelenomonasSelenomonas sp._oral_taxon_481 (SP26) -0.739920220321903 0.905546892746644 -0.817097630446974 0 0 TRUE SelenomonasSelenomonas sp._Oral_Taxon_G67 (SP260) -0.742232384802118 0.495341224618341 -1.49842643396783 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_180 (SP27) 0.455242771475473 1.45136605986843 0.313665025015633 0.753775467067439 1 FALSE ActinobaculumActinobaculum sp._oral_taxon_183 (SP271) 1.53049022755453 0.521920303032605 2.93242132689924 0.00336330123890077 0.403596148668093 FALSE PrevotellaPrevotella intermedia (SP274) -0.288495676538446 0.415092145772244 -0.695015984948892 0 0 TRUE TreponemaTreponema denticola (SP28) 0.289578675040787 0.294461564647063 0.983417565507645 0.325401968596632 1 FALSE GemellaGemella haemolysans (SP281) 2.60853137167796 0.697112293992651 3.7419098675449 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_170 (SP29) 2.04645636009678 1.18491351644464 1.72709343905301 0.0841508837285872 1 FALSE ActinomycesActinomyces cardiffensis (SP290) 0.765487901866822 0.584121897258606 1.31049341834196 0.190028969303786 1 FALSE PseudoramibacterPseudoramibacter alactolyticus (SP299) -0.0996033547702754 0.36580780216147 -0.272283297900546 0 0 TRUE GemellaGemella morbillorum (SP3) 4.48486170005998 0.935225921732118 4.79548480836976 1.62281868747469e-06 0.000227194616246456 TRUE OlsenellaOlsenella uli (SP307) -1.21479317539954 0.279812323524472 -4.34145701696836 0 0 TRUE StreptococcusStreptococcus vestibularis (SP31) 1.4926058052772 1.00899304115197 1.47930237811462 0.139059517572178 1 FALSE SelenomonasSelenomonas sp._oral_taxon_479 (SP310) -0.84759027975312 0.77981965279279 -1.08690551298319 0 0 TRUE AlloprevotellaAlloprevotella tannerae (SP311) -0.183846047785536 0.397475943650804 -0.462533772728271 0 0 TRUE SelenomonasSelenomonas sputigena (SP32) -1.72408608395703 0.651350331558078 -2.64694128554888 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_172 (SP322) -0.687318126713084 0.750545110385327 -0.9157585829321 0.359793530955147 1 FALSE StreptococcusStreptococcus sp._oral_taxon_423 (SP33) 1.62549206135549 0.840226119236774 1.93458882572232 0.0530407723461228 1 FALSE EggerthiaEggerthia catenaformis (SP34) -1.10488008498315 0.511675943626182 -2.15933560830124 0 0 TRUE Peptostreptococcaceae_[XI][G-2]Peptostreptococcaceae_[XI][G-2] sp._oral_taxon_091 (SP345) -0.295769205372621 0.572888061369042 -0.516277481268881 0 0 TRUE ActinomycesActinomyces naeslundii (SP37) 0.939653573426302 1.05018921816367 0.894746924815465 0.370922388175875 1 FALSE CapnocytophagaCapnocytophaga sp._oral_taxon_380 (SP373) 1.43033516997203 0.926767386631392 1.54335941316515 0.122743595525684 1 FALSE PropionibacteriumPropionibacterium acidifaciens (SP375) 2.25695204807963 0.821875345444161 2.74610019705595 0 0 TRUE CapnocytophagaCapnocytophaga gingivalis (SP38) 3.82522037235733 1.31382337571348 2.91151797347192 0.00359677213685436 0.428015884285669 FALSE StreptococcusStreptococcus cristatus (SP39) 0.346269545175553 1.04550352908738 0.331198829599181 0.740494304225595 1 FALSE VeillonellaVeillonella parvula_group (SP4) -5.15795832835812 1.56493594079068 -3.29595492947275 0.000980877500132692 0.122609687516586 FALSE StreptococcusStreptococcus sinensis (SP40) 0.425533763759598 1.64217595526629 0.259127995629794 0.795536484934189 1 FALSE StreptococcusStreptococcus mutans (SP42) 1.42077703720476 0.956695560949788 1.4850879372684 0.137520531067858 1 FALSE HaemophilusHaemophilus parainfluenzae (SP43) 1.88366048425973 0.944265119465057 1.99484280995877 0.046060026611213 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._animalis (SP44) -5.39459269137454 0.934825672162541 -5.77069377961687 0 0 TRUE SelenomonasSelenomonas sp._oral_taxon_134 (SP45) -1.20198164813949 0.766017182204914 -1.56913144517163 0.116617314071866 1 FALSE Bacteroidales_[G-2]Bacteroidales_[G-2] sp._oral_taxon_274 (SP46) 0.150949238928798 0.223408821183677 0.675663736682511 0 0 TRUE SelenomonasSelenomonas noxia (SP48) 0.208485653419154 0.396196379078215 0.526217967726546 0.598736771393461 1 FALSE AggregatibacterAggregatibacter sp._oral_taxon_949 (SP49) 0.901377569107179 0.955292800846401 0.943561563856178 0.345393741409917 1 FALSE RothiaRothia mucilaginosa (SP5) 5.47585885895685 1.23126430079987 4.44734640271754 8.69375808566637e-06 0.00118235109965063 TRUE DialisterDialister invisus (SP50) -2.66043861025092 0.531810408513221 -5.00260725939662 5.65600938857514e-07 8.0315333317767e-05 TRUE MogibacteriumMogibacterium diversum (SP51) -3.17663538829531 0.664705222412332 -4.77901373599373 0 0 TRUE AggregatibacterAggregatibacter sp._oral_taxon_512 (SP52) -0.62329096325278 0.990064021597332 -0.629546119903626 0.528991584976265 1 FALSE LachnoanaerobaculumLachnoanaerobaculum umeaense (SP53) -1.26200256662956 0.812162601130401 -1.55387919226157 0.120213235915927 1 FALSE Lachnospiraceae_[G-3]Lachnospiraceae_[G-3] sp._oral_taxon_100 (SP55) -0.0687732188048236 0.463977397817795 -0.148225364270505 0 0 TRUE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP56) -3.58212715972909 0.859713475159078 -4.16665233619406 0 0 TRUE PeptostreptococcusPeptostreptococcus stomatis (SP57) -4.59449784812762 1.46270482885515 -3.14109706722148 0.00168316237101022 0.205345809263247 FALSE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsp._yurii_&_margaretiae (SP59) -3.74194501041878 1.14914888459262 -3.25627519687785 0.00112884281612352 0.139976509199316 FALSE GranulicatellaGranulicatella adiacens (SP6) 0.313776769065027 0.909733417868611 0.34491067702027 0.730161523512872 1 FALSE SelenomonasSelenomonas sp._Oral_Taxon_F21 (SP61) -1.46602488689884 0.816024373182978 -1.79654546491115 0 0 TRUE OribacteriumOribacterium asaccharolyticum (SP63) -0.915272198945407 0.61848653714457 -1.4798579176372 0 0 TRUE StaphylococcusStaphylococcus epidermidis (SP65) 2.27489027533746 2.30912556911109 0.985173914216018 0.324538651613704 1 FALSE NeisseriaNeisseria mucosa (SP66) 2.51105074541313 1.27683946162869 1.96661430107285 0.0492276934861738 1 FALSE PrevotellaPrevotella maculosa (SP69) -1.00396107018008 0.583909853164306 -1.71937682630195 0.0855457790549905 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._polymorphum (SP7) -4.88757485737149 0.596639252058317 -8.19184262602583 0 0 TRUE TM7_[G-1]TM7_[G-1] sp._oral_taxon_952 (SP70) 1.51617149691712 0.955633406349559 1.58656184143748 0.112611915544616 1 FALSE AtopobiumAtopobium rimae (SP71) -1.82032995007166 0.467956623656068 -3.88995444887545 0 0 TRUE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP74) 0.18942361745829 0.781495322221975 0.242386118089247 0.808480989884185 1 FALSE TannerellaTannerella forsythia (SP75) -0.479027351747452 0.66755995589116 -0.71757951854373 0.47301658999526 1 FALSE AbiotrophiaAbiotrophia defectiva (SP76) 1.26529104893946 1.0940591450879 1.15651064626657 0.247472347439607 1 FALSE StreptococcusStreptococcus intermedius (SP8) 0.566533364696624 1.22070115026951 0.46410488314158 0.642572603372219 1 FALSE StreptococcusStreptococcus sp._oral_taxon_070 (SP80) 1.51027621821598 1.54291638357545 0.978845149544765 0.32765649733685 1 FALSE Bacteroidaceae_[G-1]Bacteroidaceae_[G-1] sp._oral_taxon_272 (SP81) -1.80789687439104 0.734793987999628 -2.46041326401265 0 0 TRUE PorphyromonasPorphyromonas endodontalis (SP82) 0.37067169666242 0.246423499443623 1.50420596046776 0.132528343513678 1 FALSE RothiaRothia dentocariosa (SP83) -0.679389932809915 1.10763976606923 -0.613367227885762 0.539633550377873 1 FALSE PrevotellaPrevotella oris (SP84) 0.150949238928798 0.223408821183677 0.675663736682511 0 0 TRUE SelenomonasSelenomonas dianae (SP87) -2.45800549280957 0.54594588895926 -4.5022877587654 0 0 TRUE SelenomonasSelenomonas sp._oral_taxon_138 (SP88) -0.586826651893989 0.478678342551101 -1.22593106837989 0 0 TRUE AggregatibacterAggregatibacter sp._Oral_Taxon_G24 (SP91) 0.723960028911173 0.815607232747725 0.887633164399734 0.374738108119096 1 FALSE ParvimonasParvimonas micra (SP92) -5.79049758025269 0.35085843547739 -16.5038003785599 0 0 TRUE PorphyromonasPorphyromonas sp._oral_taxon_279 (SP93) -1.6387159703258 0.769521763544985 -2.1295251777892 0 0 TRUE StreptococcusStreptococcus sp._oral_taxon_058 (SP98) 0.532467495879434 1.24861359420497 0.426446979554528 0.66978217481615 1 FALSE CapnocytophagaCapnocytophaga gingivalis_nov_97.509% (SPN14) 1.83103616509001 1.42087759047757 1.28866566505182 0.197514344007464 1 FALSE ActinomycesActinomyces naeslundii_nov_97.527% (SPN2) 0.906484229508212 0.837227009445109 1.08272215215441 0.278931768402214 1 FALSE SelenomonasSelenomonas sp._oral_taxon_388_nov_97.518% (SPN206) -0.655308046322194 0.873186973808191 -0.75047849541803 0 0 TRUE StreptococcusStreptococcus dentisani_nov_97.872% (SPN223) 0.613349257314528 1.07590706598083 0.570076428260445 0.568625861859141 1 FALSE FusobacteriumFusobacterium sp._oral_taxon_370_nov_97.153% (SPN244) -0.0687732188048236 0.463977397817795 -0.148225364270505 0 0 TRUE VeillonellaVeillonella sp._oral_taxon_780_nov_86.786% (SPN254) -1.24562331136499 0.688879112703508 -1.80818853176799 0.0705771628998772 1 FALSE StreptococcusStreptococcus dentisani_nov_97.518% (SPN27) 0.0898729090185618 0.796704438076693 0.112805834539496 0.910184492579039 1 FALSE ActinomycesActinomyces sp._oral_taxon_175_nov_96.809% (SPN43) 1.17124746363904 0.754954863948149 1.55141389183696 0.120802528211262 1 FALSE FusobacteriumFusobacterium nucleatum_subsp._polymorphum_periodonticum (SPP1) -0.346032091028802 0.387745462139816 -0.892420736839023 0 0 TRUE VeillonellaVeillonella atypica_parvula_group (SPP12) -1.52325289731883 0.950346557047607 -1.60283939161209 0 0 TRUE LactobacillusLactobacillus casei_rhamnosus (SPP13) 1.1827602987717 0.830102453661766 1.42483652897818 0.154204460351985 1 FALSE SelenomonasSelenomonas dianae_sp._oral_taxon_920 (SPP14) -0.704383984874413 0.658136881020141 -1.07026973443972 0 0 TRUE VeillonellaVeillonella denticariosi_parvula_group (SPP22) -2.88045715857517 0.516779084216854 -5.57386559663173 0 0 TRUE SelenomonasSelenomonas dianae_infelix_sp._oral_taxon_138 (SPP24) -0.688991776647187 0.663648164212929 -1.03818832598492 0 0 TRUE SelenomonasSelenomonas infelix_sp._oral_taxon_138 (SPP25) -1.15464234459571 0.7227058175215 -1.59766576745643 0 0 TRUE SelenomonasSelenomonas dianae_sp._oral_taxon_138 (SPP26) -1.15735293787665 0.705859911319877 -1.63963545643573 0 0 TRUE StomatobaculumStomatobaculum longum_sp._oral_taxon_097 (SPP6) -1.13739949527239 1.05091608167584 -1.08229335824669 0 0 TRUE StreptococcusStreptococcus salivarius_vestibularis (SPP8) 0.72994737967929 0.636440310943639 1.14692197701464 0.251413868803841 1 FALSE FusobacteriumFusobacterium naviforme_nucleatum_subsp._vincentii (SPP9) -1.21228837816253 0.925025132043106 -1.31054642319279 0 0 TRUE SelenomonasSelenomonas multispecies_sppn20_2_nov_97.509% (SPPN20) -0.825611145588476 0.810330772487053 -1.01885695770201 0 0 TRUE