GroupMetronidazole...1 GroupMetronidazole...2 GroupMetronidazole...3 GroupMetronidazole...4 GroupMetronidazole...5 GroupMetronidazole...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance FusobacteriumFusobacterium nucleatum_subsp._animalis (SP1) -5.13531673639009 0.94364732730487 -5.44198726345886 0 0 TRUE Bacteroidaceae_[G-1]Bacteroidaceae_[G-1] sp._oral_taxon_272 (SP10) -1.39188482143167 0.599115932018484 -2.32323119290495 0 0 TRUE PropionibacteriumPropionibacterium propionicum (SP104) 3.7246346882294 0.521454098774084 7.14278533237318 0 0 TRUE StomatobaculumStomatobaculum sp._oral_taxon_373 (SP105) -0.280090668109286 0.43198938833103 -0.64837395472005 0 0 TRUE Peptostreptococcaceae_[XI][G-7]Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsp._yurii_&_margaretiae (SP11) -3.05402888933852 1.11531345996639 -2.7382695528758 0 0 TRUE StomatobaculumStomatobaculum sp._oral_taxon_097 (SP112) -2.15851191187657 0.813362529634769 -2.65381282420992 0 0 TRUE SelenomonasSelenomonas dianae (SP114) -1.78243204425681 0.615390485695481 -2.89642444218552 0 0 TRUE OribacteriumOribacterium asaccharolyticum (SP115) -0.645716090789072 0.473781380492884 -1.36289883346053 0 0 TRUE ParvimonasParvimonas micra (SP12) -4.92955521677846 0.312183158460498 -15.7905866578072 0 0 TRUE ActinomycesActinomyces sp._oral_taxon_169 (SP121) 1.03575957429273 0.826890435330711 1.252595906347 0.210352805421854 1 FALSE RothiaRothia aeria (SP122) 0.967964500924868 0.726836195316898 1.33175054731945 0.182942173164781 1 FALSE GemellaGemella morbillorum (SP125) 3.24679249553988 0.952034023644278 3.41037443505593 0.000648737483375098 0.0674686982710102 FALSE FusobacteriumFusobacterium nucleatum_subsp._nucleatum (SP126) -1.4341711005088 0.71767933535492 -1.99834526348673 0 0 TRUE FusobacteriumFusobacterium periodonticum (SP129) -1.07033941182557 0.605843732065441 -1.76669222635443 0 0 TRUE EikenellaEikenella corrodens (SP13) 1.45706505496029 0.481281775305254 3.02746775324318 0.00246612024567281 0.246612024567281 FALSE ParvimonasParvimonas sp._oral_taxon_393 (SP134) -0.26469845988206 0.417405360956244 -0.634152036944748 0 0 TRUE StreptococcusStreptococcus gordonii (SP135) -0.146640500858013 0.625960825806404 -0.234264661321419 0.814779518811318 1 FALSE GranulicatellaGranulicatella adiacens (SP14) 0.198424859841577 0.950615997218767 0.208732927304097 0.834656734007655 1 FALSE ActinomycesActinomyces sp._oral_taxon_180 (SP147) -0.11284798380412 1.07565441862551 -0.104911002874249 0.916446428120476 1 FALSE LeptotrichiaLeptotrichia wadei (SP15) -0.452699911580354 0.273573700555374 -1.65476400202703 0 0 TRUE AtopobiumAtopobium sp._oral_taxon_199 (SP150) -0.280090668109286 0.394014991856157 -0.710862971964119 0 0 TRUE CampylobacterCampylobacter rectus (SP153) -0.680586768218027 0.602237092078051 -1.13009772591327 0 0 TRUE PrevotellaPrevotella saccharolytica (SP157) -0.845421856811297 0.504275277754037 -1.67650863349215 0 0 TRUE AtopobiumAtopobium parvulum (SP158) -2.09513220770622 0.359580341377557 -5.82660386738537 0 0 TRUE AbiotrophiaAbiotrophia defectiva (SP159) 0.723630024639801 0.59101253544863 1.2243903153264 0.220805020981406 1 FALSE TreponemaTreponema denticola (SP16) -0.036811603244387 0.192641012334042 -0.191089128936652 0 0 TRUE Peptostreptococcaceae_[XI][G-9]Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP160) -0.811051805425965 0.481870985970615 -1.6831306076507 0 0 TRUE TM7_[G-1]TM7_[G-1] sp._oral_taxon_952 (SP161) 1.08704548008227 0.863209875346906 1.25930612140577 0.207919783054752 1 FALSE LachnoanaerobaculumLachnoanaerobaculum saburreum (SP167) -1.31113397269076 0.314684786215516 -4.16649939915689 0 0 TRUE StreptococcusStreptococcus dentisani (SP17) 0.652481068291352 1.40538045737562 0.464273617060096 0.642451723671272 1 FALSE SelenomonasSelenomonas sp._oral_taxon_919 (SP170) -0.545917857565274 0.516183274891431 -1.05760469995874 0 0 TRUE CapnocytophagaCapnocytophaga sp._oral_taxon_412 (SP173) 0.809429145743473 0.763176128220823 1.06060595426442 0.288869015471876 1 FALSE StreptococcusStreptococcus sp._str._C300 (SP178) 0.737428598937191 0.280544263765516 2.62856416680666 0 0 TRUE StreptococcusStreptococcus parasanguinis_I (SP179) 1.65029823723076 0.597244824124765 2.76318549875957 0 0 TRUE Peptostreptococcaceae_[XI][G-1]Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP18) -0.314070475468365 0.38752431887753 -0.810453590056168 0 0 TRUE DialisterDialister invisus (SP181) -0.601978250596106 0.421323905470341 -1.42877781863361 0 0 TRUE EikenellaEikenella sp._oral_taxon_011 (SP182) 0.625505441350107 0.714104640485294 0.875929668969835 0.381068269283182 1 FALSE LachnoanaerobaculumLachnoanaerobaculum umeaense (SP183) -0.909112603035004 0.538430143027544 -1.68845042352782 0.0913247980806696 1 FALSE PyramidobacterPyramidobacter piscolens (SP185) -0.557349540333264 0.597641210935217 -0.932582174949243 0 0 TRUE ActinomycesActinomyces timonensis (SP189) 1.53460716973611 1.01765603589114 1.50798218220392 0.131559087313779 1 FALSE StaphylococcusStaphylococcus epidermidis (SP19) 1.63921219124702 1.81806638649786 0.901623946969636 0.367256665643831 1 FALSE OribacteriumOribacterium sinus (SP190) -2.2817148955847 0.321787455426774 -7.09075154144389 0 0 TRUE Lachnospiraceae_[G-8]Lachnospiraceae_[G-8] sp._oral_taxon_500 (SP191) -0.301162771240851 0.491445504336838 -0.612810105257232 0 0 TRUE StreptococcusStreptococcus parasanguinis_II (SP2) 1.37959732957138 0.851988514997214 1.61926751979267 0.105389715934277 1 FALSE CapnocytophagaCapnocytophaga gingivalis (SP20) 3.7522695460064 1.17391419507863 3.19637462579202 0.001391662921876 0.140557955109476 FALSE MegasphaeraMegasphaera micronuciformis (SP203) -0.578421643464829 0.619727252569997 -0.933348728922482 0 0 TRUE SelenomonasSelenomonas infelix (SP209) -0.672422369313976 0.600769982512051 -1.11926758807476 0 0 TRUE StreptococcusStreptococcus sp._oral_taxon_423 (SP21) 1.73407621859997 0.805600017513272 2.15252753339396 0.0313558291341513 1 FALSE ActinomycesActinomyces lingnae_[NVP] (SP210) 0.481241829844778 0.39996478330494 1.20321050735577 0.228894869836006 1 FALSE StreptococcusStreptococcus intermedius (SP217) 0.423705415354422 0.409309237146111 1.03517188693001 0.300588645361696 1 FALSE AtopobiumAtopobium rimae (SP22) -1.65907720390173 0.399592896406543 -4.15191866227221 0 0 TRUE ActinomycesActinomyces naeslundii (SP223) 0.321540290601224 0.3397930985383 0.946282581913539 0.344004474995424 1 FALSE ActinomycesActinomyces sp._oral_taxon_170 (SP230) 1.49121303129469 0.59189387430673 2.51939257361179 0 0 TRUE StreptococcusStreptococcus tigurinus (SP24) 1.96840115680356 1.33523686139868 1.47419623716921 0.1404287627099 1 FALSE AggregatibacterAggregatibacter sp._oral_taxon_458 (SP256) 0.619871265956767 0.488577555024951 1.26872644799475 0.204538646095971 1 FALSE CampylobacterCampylobacter sp._Oral_Taxon_G43 (SP262) -0.623050353727671 0.704005887157123 -0.885007306179836 0 0 TRUE CatonellaCatonella morbi (SP268) 0.101817832867602 0.242461482176111 0.419934052839152 0 0 TRUE StreptococcusStreptococcus sp._oral_taxon_070 (SP27) 1.4544269422351 1.23414015998283 1.17849413656171 0.238599668517847 1 FALSE GemellaGemella sanguinis (SP272) 1.81554712746863 0.674330064551197 2.69237161875168 0 0 TRUE PseudoramibacterPseudoramibacter alactolyticus (SP276) 0.101817832867602 0.156005944567117 0.652653545671765 0 0 TRUE NeisseriaNeisseria flavescens|subflava (SP29) 0.849351756524276 0.452012538907738 1.87904467999203 0.0602383927145683 1 FALSE PropionibacteriumPropionibacterium acnes (SP298) 1.57736961451318 0.527026589275564 2.99296021607067 0 0 TRUE FusobacteriumFusobacterium nucleatum_subsp._polymorphum (SP30) -4.90185214638515 0.55045570665261 -8.90508007664037 0 0 TRUE PrevotellaPrevotella oralis (SP304) -0.314070475468365 0.476888350771401 -0.658582821241773 0 0 TRUE OlsenellaOlsenella uli (SP309) -1.12003168368527 0.299054777288774 -3.74523922954671 0 0 TRUE FusobacteriumFusobacterium nucleatum_subsp._vincentii (SP33) -3.61126904332785 0.867981221364599 -4.16053821723283 0 0 TRUE RothiaRothia dentocariosa (SP34) -0.0647639917194187 0.860326786008267 -0.0752783625625674 0.939993236799985 1 FALSE FusobacteriumFusobacterium sp._oral_taxon_203 (SP35) -0.919371261912514 0.570335793102707 -1.61198240235109 0 0 TRUE AnaeroglobusAnaeroglobus geminatus (SP354) -0.868588219916321 0.48390099195478 -1.79497094314179 0 0 TRUE StreptococcusStreptococcus sp._oral_taxon_058 (SP36) 0.722607004506447 0.976192140602256 0.74023030349398 0.45916026301381 1 FALSE StreptococcusStreptococcus sinensis (SP38) 0.490149400730959 1.210712437903 0.40484378072461 0.685592345037485 1 FALSE HaemophilusHaemophilus parainfluenzae (SP39) 1.80766420859099 0.995469556681886 1.81589099983763 0.0693870941937323 1 FALSE RothiaRothia mucilaginosa (SP4) 5.96713485333983 1.36646638273712 4.36683619057446 1.26059195939606e-05 0.00141186299452358 TRUE LeptotrichiaLeptotrichia buccalis (SP40) -0.036811603244387 0.29094276288865 -0.126525241181117 0 0 TRUE CampylobacterCampylobacter showae (SP41) -2.8988329622044 1.04328539131229 -2.77856182626894 0 0 TRUE StreptococcusStreptococcus cristatus (SP42) 0.718134336898784 0.936796274499083 0.766585389425016 0.443328065038231 1 FALSE StreptococcusStreptococcus vestibularis (SP43) 1.10305402161698 0.639371978191926 1.72521483461989 0.0844887632355841 1 FALSE StreptococcusStreptococcus salivarius (SP44) 0.513582283763022 0.923489094524533 0.55613248365152 0.578120290203302 1 FALSE CampylobacterCampylobacter gracilis (SP45) -3.00782784124742 0.467118624144241 -6.43910922361049 0 0 TRUE OribacteriumOribacterium sp._oral_taxon_078 (SP46) -2.3781231658264 0.698513039817694 -3.40455085340578 0 0 TRUE CampylobacterCampylobacter concisus (SP47) -3.69834095152881 0.478391260950671 -7.73078702186027 0 0 TRUE MogibacteriumMogibacterium timidum (SP49) -2.09913475885714 0.536546485975112 -3.91230734657073 0 0 TRUE StreptococcusStreptococcus anginosus (SP5) 0.736093724669992 0.684914240796587 1.07472393012865 0.282498346620898 1 FALSE VeillonellaVeillonella atypica (SP52) -2.98191190078237 1.14690110569551 -2.59997299328966 0.0093231097358273 0.820433656752802 FALSE StreptococcusStreptococcus mitis (SP53) 1.70180723283707 0.658093473045505 2.5859658278656 0.00971065573437888 0.844827048890962 FALSE PropionibacteriumPropionibacterium acidifaciens (SP54) 1.89109279809595 0.747846451589613 2.52871801969009 0 0 TRUE FusobacteriumFusobacterium sp._oral_taxon_370 (SP56) -1.49945568066245 0.831653802910076 -1.80298060973886 0 0 TRUE StreptococcusStreptococcus constellatus (SP57) 0.107381463144494 0.757022034513237 0.141847209524806 0.887200693243281 1 FALSE FusobacteriumFusobacterium canifelinum (SP58) -0.835532201728501 0.631137100846587 -1.32385214022079 0 0 TRUE MogibacteriumMogibacterium diversum (SP6) -2.57152623215594 0.556532256921052 -4.62062387251838 0 0 TRUE StreptococcusStreptococcus sanguinis (SP60) 1.12334334488432 0.73351041178962 1.53146203084368 0.125655243481079 1 FALSE VeillonellaVeillonella sp._oral_taxon_780 (SP61) -0.545917857565274 0.687057434057117 -0.794573831101128 0 0 TRUE StreptococcusStreptococcus oralis (SP62) 1.92921041330188 0.865102238129483 2.23003747796701 0.0257449548998487 1 FALSE StreptococcusStreptococcus sp._Oral_Taxon_B66 (SP63) 0.020724811245969 0.301007855142084 0.0688513967058645 0.945107906464877 1 FALSE PorphyromonasPorphyromonas sp._oral_taxon_279 (SP65) 0.101817832867602 0.191010202870696 0.533049184480095 0 0 TRUE StomatobaculumStomatobaculum longum (SP66) -3.79239136621857 0.909950298341024 -4.1676906674273 0 0 TRUE FusobacteriumFusobacterium sp._HOT_204 (SP68) -0.685525290736102 0.661200098364015 -1.03678945667473 0 0 TRUE SlackiaSlackia exigua (SP69) -2.48106542172668 0.431218122164336 -5.75362048624931 0 0 TRUE VeillonellaVeillonella parvula_group (SP7) -5.13948483578972 1.55681235377895 -3.3012872895788 0.000962422802405858 0.0981671258453975 FALSE LeptotrichiaLeptotrichia sp._oral_taxon_498 (SP70) -0.314070475468365 0.334004080162538 -0.940319277882857 0 0 TRUE DialisterDialister pneumosintes (SP73) -2.1033649709931 0.294292819967205 -7.14718412507478 0 0 TRUE StreptococcusStreptococcus sp._oral_taxon_064 (SP78) 1.46891618459301 0.969188330978712 1.51561480637067 0.129616780904276 1 FALSE LeptotrichiaLeptotrichia sp._oral_taxon_215 (SP79) -0.672422369313976 0.273967188214515 -2.4543901541504 0 0 TRUE PeptostreptococcusPeptostreptococcus stomatis (SP8) -3.68261172564105 1.23800184956067 -2.97464153785223 0 0 TRUE PrevotellaPrevotella maculosa (SP80) -0.672422369313976 0.466922128700859 -1.44011673035264 0 0 TRUE ActinomycesActinomyces odontolyticus (SP83) 1.26267268132334 1.04891310014048 1.20379150680283 0.22867017321938 1 FALSE PrevotellaPrevotella salivae (SP85) 0.0207248112459691 0.315545691769675 0.0656792717711916 0 0 TRUE SelenomonasSelenomonas sputigena (SP86) -0.879237122820083 0.548272125295044 -1.60365096501475 0 0 TRUE TannerellaTannerella forsythia (SP87) -0.0711816546297191 0.598125463472671 -0.119007898805117 0.905269097916271 1 FALSE SolobacteriumSolobacterium moorei (SP88) -1.56939917333669 0.373551585817042 -4.20129169015322 0 0 TRUE PrevotellaPrevotella denticola (SP89) -0.198997646487653 0.391101560343851 -0.508813225681577 0 0 TRUE LeptotrichiaLeptotrichia sp._oral_taxon_417 (SP9) -0.036811603244387 0.317281381785045 -0.116021945685192 0 0 TRUE PrevotellaPrevotella sp._oral_taxon_317 (SP91) -0.533792933201987 0.506635888681704 -1.05360268612424 0 0 TRUE MycoplasmaMycoplasma salivarium (SP97) 0.920686745312022 0.348594425579178 2.64114018398984 0 0 TRUE CapnocytophagaCapnocytophaga gingivalis_nov_97.912% (SPN106) 1.6345932846083 1.30826278180801 1.24943803900719 0.211504902763269 1 FALSE ActinomycesActinomyces naeslundii_nov_97.980% (SPN123) 0.849351756524276 0.451856496129098 1.8796935836939 0.0601498505520345 1 FALSE LaceyellaLaceyella sediminis_nov_84.583% (SPN37) 1.11685259591437 0.944322560401077 1.18270243955626 0.23692709702815 1 FALSE ActinomycesActinomyces meyeri_nov_87.247% (SPN82) 1.96367389683382 0.658662004149056 2.98130738446154 0.0028702053954211 0.281280128751268 FALSE Clostridiales_[G]Clostridiales_[G] sp._Oral_Taxon_C16_nov_79.093% (SPN93) -0.710270769241682 0.641690929236226 -1.10687363165174 0 0 TRUE FusobacteriumFusobacterium naviforme_nucleatum_subsp._vincentii (SPP11) -0.337627082599642 0.525814876238721 -0.642102568521395 0 0 TRUE StreptococcusStreptococcus salivarius_vestibularis (SPP12) 0.481241829844778 0.442484031966962 1.08759140461075 0.2767755269631 1 FALSE OribacteriumOribacterium asaccharolyticum_parvum (SPP3) -0.578421643464829 0.364197641301859 -1.5882080987598 0 0 TRUE VeillonellaVeillonella denticariosi_parvula_group (SPP4) -0.690344801051914 0.474380807249943 -1.45525449280705 0.145598819928413 1 FALSE