Table of Content
I.Project Summary
II.Workflow Checklist
III.NGS Sequencing Results
IV.Complete Report Download
V.Raw Sequence Data Download
VI.Analysis - DADA2 Read Processing
 Sample Meta Info
 Read Count by Sample
VII.Analysis - Read Taxonomy Assignment
 Taxonomy Barplots
VIII.Analysis - Alpha Diversity
IX.Analysis - Beta Diversity
X.Analysis - Differential Abundance
 ANCOM Result
 LEfSe Result
XI.Analysis - Heatmap Profile
XII.Analysis - Network Association
XIII.Disclaimer

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FOMC Service Report

16S rRNA Gene V1V3 Amplicon Sequencing

Version V1.43

Version History

The Forsyth Institute, Cambridge, MA, USA
November 07, 2024

Project ID: FOMC17924_haleon_16S

I. Project Summary

Project FOMC17924_haleon_16S services include NGS sequencing of the V1V3 region of the 16S rRNA gene amplicons from the samples. First and foremost, please download this report, as well as the sequence raw data from the download links provided below. These links will expire after 60 days. We cannot guarantee the availability of your data after 60 days.

Full Bioinformatics analysis service was requested. We provide many analyses, starting from the raw sequence quality and noise filtering, pair reads merging, as well as chimera filtering for the sequences, using the DADA2 denosing algorithm and pipeline.

We also provide many downstream analyses such as taxonomy assignment, alpha and beta diversity analyses, and differential abundance analysis.

For taxonomy assignment, most informative would be the taxonomy barplots. We provide an interactive barplots to show the relative abundance of microbes at different taxonomy levels (from Phylum to species) that you can choose.

If you specify which groups of samples you want to compare for differential abundance, we provide both ANCOM and LEfSe differential abundance analysis.

 

II. Workflow Checklist

☑1.Sample Received
☑2.Sample Quality Evaluated
☑3.Sample Prepared for Sequencing
☑4.Next-Gen Sequencing
☑5.Sequence Quality Check
☑6.Absolute Abundance
☑7.Report and Raw Sequence Data Available for Download
☑8.Bioinformatics Analysis - Reads Processing (DADA2 Quality Trimming, Denoising, Paired Reads Merging)
☑9.Bioinformatics Analysis - Reads Taxonomy Assignment
☑10.Bioinformatics Analysis - Alpha Diversity Analysis
☑11.Bioinformatics Analysis - Beta Diversity Analysis
☑12.Bioinformatics Analysis - Differential Abundance Analysis
☑13.Bioinformatics Analysis - Heatmap Profile
☑14.Bioinformatics Analysis - Network Association
 

III. NGS Sequencing

The samples were processed and analyzed with the ZymoBIOMICS® Service: Targeted Metagenomic Sequencing (Zymo Research, Irvine, CA).

DNA Extraction: If DNA extraction was performed, one of three different DNA extraction kits was used depending on the sample type and sample volume and were used according to the manufacturer’s instructions, unless otherwise stated. The kit used in this project is marked below:

☐ZymoBIOMICS® DNA Miniprep Kit (Zymo Research, Irvine, CA)
☐ZymoBIOMICS® DNA Microprep Kit (Zymo Research, Irvine, CA)
☐ZymoBIOMICS®-96 MagBead DNA Kit (Zymo Research, Irvine, CA)
☑N/A (DNA Extraction Not Performed)
Elution Volume: 50µL
Additional Notes: NA

Targeted Library Preparation: The DNA samples were prepared for targeted sequencing with the Quick-16S™ NGS Library Prep Kit (Zymo Research, Irvine, CA). These primers were custom designed by Zymo Research to provide the best coverage of the 16S gene while maintaining high sensitivity. The primer sets used in this project are marked below:

☐Quick-16S™ Primer Set V1-V2 (Zymo Research, Irvine, CA)
☑Quick-16S™ Primer Set V1-V3 (Zymo Research, Irvine, CA)
☐Quick-16S™ Primer Set V3-V4 (Zymo Research, Irvine, CA)
☐Quick-16S™ Primer Set V4 (Zymo Research, Irvine, CA)
☐Quick-16S™ Primer Set V6-V8 (Zymo Research, Irvine, CA)
☐Other: NA
Additional Notes: NA

The sequencing library was prepared using an innovative library preparation process in which PCR reactions were performed in real-time PCR machines to control cycles and therefore limit PCR chimera formation. The final PCR products were quantified with qPCR fluorescence readings and pooled together based on equal molarity. The final pooled library was cleaned up with the Select-a-Size DNA Clean & Concentrator™ (Zymo Research, Irvine, CA), then quantified with TapeStation® (Agilent Technologies, Santa Clara, CA) and Qubit® (Thermo Fisher Scientific, Waltham, WA).

Control Samples: The ZymoBIOMICS® Microbial Community Standard (Zymo Research, Irvine, CA) was used as a positive control for each DNA extraction, if performed. The ZymoBIOMICS® Microbial Community DNA Standard (Zymo Research, Irvine, CA) was used as a positive control for each targeted library preparation. Negative controls (i.e. blank extraction control, blank library preparation control) were included to assess the level of bioburden carried by the wet-lab process.

Sequencing: The final library was sequenced on Illumina® MiSeq™ with a V3 reagent kit (600 cycles). The sequencing was performed with 10% PhiX spike-in.

Absolute Abundance Quantification*: A quantitative real-time PCR was set up with a standard curve. The standard curve was made with plasmid DNA containing one copy of the 16S gene and one copy of the fungal ITS2 region prepared in 10-fold serial dilutions. The primers used were the same as those used in Targeted Library Preparation. The equation generated by the plasmid DNA standard curve was used to calculate the number of gene copies in the reaction for each sample. The PCR input volume (2 µl) was used to calculate the number of gene copies per microliter in each DNA sample.
The number of genome copies per microliter DNA sample was calculated by dividing the gene copy number by an assumed number of gene copies per genome. The value used for 16S copies per genome is 4. The value used for ITS copies per genome is 200. The amount of DNA per microliter DNA sample was calculated using an assumed genome size of 4.64 x 106 bp, the genome size of Escherichia coli, for 16S samples, or an assumed genome size of 1.20 x 107 bp, the genome size of Saccharomyces cerevisiae, for ITS samples. This calculation is shown below:

Calculated Total DNA = Calculated Total Genome Copies × Assumed Genome Size (4.64 × 106 bp) ×
Average Molecular Weight of a DNA bp (660 g/mole/bp) ÷ Avogadro’s Number (6.022 x 1023/mole)


* Absolute Abundance Quantification is only available for 16S and ITS analyses.

The absolute abundance standard curve data can be viewed in Excel here:

The absolute abundance standard curve is shown below:

Absolute Abundance Standard Curve

 

IV. Complete Report Download

The complete report of your project, including all links in this report, can be downloaded by clicking the link provided below. The downloaded file is a compressed ZIP file and once unzipped, open the file “REPORT.html” (may only shown as "REPORT" in your computer) by double clicking it. Your default web browser will open it and you will see the exact content of this report.

Please download and save the file to your computer storage device. The download link will expire after 60 days upon your receiving of this report.

Complete report download link:

To view the report, please follow the following steps:
1.Download the .zip file from the report link above.
2.Extract all the contents of the downloaded .zip file to your desktop.
3.Open the extracted folder and find the "REPORT.html" (may shown as only "REPORT").
4.Open (double-clicking) the REPORT.html file. Your default browser will open the top age of the complete report. Within the report, there are links to view all the analyses performed for the project.

 

V. Raw Sequence Data Download

The raw NGS sequence data is available for download with the link provided below. The data is a compressed ZIP file and can be unzipped to individual sequence files. Since this is a pair-end sequencing, each of your samples is represented by two sequence files, one for READ 1, with the file extension “*_R1.fastq.gz”, another READ 2, with the file extension “*_R1.fastq.gz”. The files are in FASTQ format and are compressed. FASTQ format is a text-based data format for storing both a biological sequence and its corresponding quality scores. Most sequence analysis software will be able to open them. The Sample IDs associated with the R1 and R2 fastq files are listed in the table below:



Sample IDOriginal Sample IDRead 1 File NameRead 2 File Name


F17924.S100original sample ID herezr17924_100V1V3_R1.fastq.gzzr17924_100V1V3_R2.fastq.gz


F17924.S101original sample ID herezr17924_101V1V3_R1.fastq.gzzr17924_101V1V3_R2.fastq.gz


F17924.S102original sample ID herezr17924_102V1V3_R1.fastq.gzzr17924_102V1V3_R2.fastq.gz


F17924.S103original sample ID herezr17924_103V1V3_R1.fastq.gzzr17924_103V1V3_R2.fastq.gz


F17924.S104original sample ID herezr17924_104V1V3_R1.fastq.gzzr17924_104V1V3_R2.fastq.gz


F17924.S105original sample ID herezr17924_105V1V3_R1.fastq.gzzr17924_105V1V3_R2.fastq.gz


F17924.S106original sample ID herezr17924_106V1V3_R1.fastq.gzzr17924_106V1V3_R2.fastq.gz


F17924.S107original sample ID herezr17924_107V1V3_R1.fastq.gzzr17924_107V1V3_R2.fastq.gz


F17924.S108original sample ID herezr17924_108V1V3_R1.fastq.gzzr17924_108V1V3_R2.fastq.gz


F17924.S109original sample ID herezr17924_109V1V3_R1.fastq.gzzr17924_109V1V3_R2.fastq.gz


F17924.S010original sample ID herezr17924_10V1V3_R1.fastq.gzzr17924_10V1V3_R2.fastq.gz


F17924.S110original sample ID herezr17924_110V1V3_R1.fastq.gzzr17924_110V1V3_R2.fastq.gz


F17924.S111original sample ID herezr17924_111V1V3_R1.fastq.gzzr17924_111V1V3_R2.fastq.gz


F17924.S112original sample ID herezr17924_112V1V3_R1.fastq.gzzr17924_112V1V3_R2.fastq.gz


F17924.S113original sample ID herezr17924_113V1V3_R1.fastq.gzzr17924_113V1V3_R2.fastq.gz


F17924.S114original sample ID herezr17924_114V1V3_R1.fastq.gzzr17924_114V1V3_R2.fastq.gz


F17924.S115original sample ID herezr17924_115V1V3_R1.fastq.gzzr17924_115V1V3_R2.fastq.gz


F17924.S116original sample ID herezr17924_116V1V3_R1.fastq.gzzr17924_116V1V3_R2.fastq.gz


F17924.S117original sample ID herezr17924_117V1V3_R1.fastq.gzzr17924_117V1V3_R2.fastq.gz


F17924.S118original sample ID herezr17924_118V1V3_R1.fastq.gzzr17924_118V1V3_R2.fastq.gz


F17924.S119original sample ID herezr17924_119V1V3_R1.fastq.gzzr17924_119V1V3_R2.fastq.gz


F17924.S011original sample ID herezr17924_11V1V3_R1.fastq.gzzr17924_11V1V3_R2.fastq.gz


F17924.S120original sample ID herezr17924_120V1V3_R1.fastq.gzzr17924_120V1V3_R2.fastq.gz


F17924.S121original sample ID herezr17924_121V1V3_R1.fastq.gzzr17924_121V1V3_R2.fastq.gz


F17924.S122original sample ID herezr17924_122V1V3_R1.fastq.gzzr17924_122V1V3_R2.fastq.gz


F17924.S123original sample ID herezr17924_123V1V3_R1.fastq.gzzr17924_123V1V3_R2.fastq.gz


F17924.S124original sample ID herezr17924_124V1V3_R1.fastq.gzzr17924_124V1V3_R2.fastq.gz


F17924.S125original sample ID herezr17924_125V1V3_R1.fastq.gzzr17924_125V1V3_R2.fastq.gz


F17924.S126original sample ID herezr17924_126V1V3_R1.fastq.gzzr17924_126V1V3_R2.fastq.gz


F17924.S127original sample ID herezr17924_127V1V3_R1.fastq.gzzr17924_127V1V3_R2.fastq.gz


F17924.S128original sample ID herezr17924_128V1V3_R1.fastq.gzzr17924_128V1V3_R2.fastq.gz


F17924.S129original sample ID herezr17924_129V1V3_R1.fastq.gzzr17924_129V1V3_R2.fastq.gz


F17924.S012original sample ID herezr17924_12V1V3_R1.fastq.gzzr17924_12V1V3_R2.fastq.gz


F17924.S130original sample ID herezr17924_130V1V3_R1.fastq.gzzr17924_130V1V3_R2.fastq.gz


F17924.S131original sample ID herezr17924_131V1V3_R1.fastq.gzzr17924_131V1V3_R2.fastq.gz


F17924.S132original sample ID herezr17924_132V1V3_R1.fastq.gzzr17924_132V1V3_R2.fastq.gz


F17924.S133original sample ID herezr17924_133V1V3_R1.fastq.gzzr17924_133V1V3_R2.fastq.gz


F17924.S134original sample ID herezr17924_134V1V3_R1.fastq.gzzr17924_134V1V3_R2.fastq.gz


F17924.S135original sample ID herezr17924_135V1V3_R1.fastq.gzzr17924_135V1V3_R2.fastq.gz


F17924.S136original sample ID herezr17924_136V1V3_R1.fastq.gzzr17924_136V1V3_R2.fastq.gz


F17924.S137original sample ID herezr17924_137V1V3_R1.fastq.gzzr17924_137V1V3_R2.fastq.gz


F17924.S138original sample ID herezr17924_138V1V3_R1.fastq.gzzr17924_138V1V3_R2.fastq.gz


F17924.S139original sample ID herezr17924_139V1V3_R1.fastq.gzzr17924_139V1V3_R2.fastq.gz


F17924.S013original sample ID herezr17924_13V1V3_R1.fastq.gzzr17924_13V1V3_R2.fastq.gz


F17924.S140original sample ID herezr17924_140V1V3_R1.fastq.gzzr17924_140V1V3_R2.fastq.gz


F17924.S141original sample ID herezr17924_141V1V3_R1.fastq.gzzr17924_141V1V3_R2.fastq.gz


F17924.S142original sample ID herezr17924_142V1V3_R1.fastq.gzzr17924_142V1V3_R2.fastq.gz


F17924.S143original sample ID herezr17924_143V1V3_R1.fastq.gzzr17924_143V1V3_R2.fastq.gz


F17924.S144original sample ID herezr17924_144V1V3_R1.fastq.gzzr17924_144V1V3_R2.fastq.gz


F17924.S145original sample ID herezr17924_145V1V3_R1.fastq.gzzr17924_145V1V3_R2.fastq.gz


F17924.S146original sample ID herezr17924_146V1V3_R1.fastq.gzzr17924_146V1V3_R2.fastq.gz


F17924.S147original sample ID herezr17924_147V1V3_R1.fastq.gzzr17924_147V1V3_R2.fastq.gz


F17924.S148original sample ID herezr17924_148V1V3_R1.fastq.gzzr17924_148V1V3_R2.fastq.gz


F17924.S149original sample ID herezr17924_149V1V3_R1.fastq.gzzr17924_149V1V3_R2.fastq.gz


F17924.S014original sample ID herezr17924_14V1V3_R1.fastq.gzzr17924_14V1V3_R2.fastq.gz


F17924.S150original sample ID herezr17924_150V1V3_R1.fastq.gzzr17924_150V1V3_R2.fastq.gz


F17924.S151original sample ID herezr17924_151V1V3_R1.fastq.gzzr17924_151V1V3_R2.fastq.gz


F17924.S152original sample ID herezr17924_152V1V3_R1.fastq.gzzr17924_152V1V3_R2.fastq.gz


F17924.S153original sample ID herezr17924_153V1V3_R1.fastq.gzzr17924_153V1V3_R2.fastq.gz


F17924.S154original sample ID herezr17924_154V1V3_R1.fastq.gzzr17924_154V1V3_R2.fastq.gz


F17924.S155original sample ID herezr17924_155V1V3_R1.fastq.gzzr17924_155V1V3_R2.fastq.gz


F17924.S156original sample ID herezr17924_156V1V3_R1.fastq.gzzr17924_156V1V3_R2.fastq.gz


F17924.S157original sample ID herezr17924_157V1V3_R1.fastq.gzzr17924_157V1V3_R2.fastq.gz


F17924.S158original sample ID herezr17924_158V1V3_R1.fastq.gzzr17924_158V1V3_R2.fastq.gz


F17924.S159original sample ID herezr17924_159V1V3_R1.fastq.gzzr17924_159V1V3_R2.fastq.gz


F17924.S015original sample ID herezr17924_15V1V3_R1.fastq.gzzr17924_15V1V3_R2.fastq.gz


F17924.S160original sample ID herezr17924_160V1V3_R1.fastq.gzzr17924_160V1V3_R2.fastq.gz


F17924.S161original sample ID herezr17924_161V1V3_R1.fastq.gzzr17924_161V1V3_R2.fastq.gz


F17924.S162original sample ID herezr17924_162V1V3_R1.fastq.gzzr17924_162V1V3_R2.fastq.gz


F17924.S163original sample ID herezr17924_163V1V3_R1.fastq.gzzr17924_163V1V3_R2.fastq.gz


F17924.S164original sample ID herezr17924_164V1V3_R1.fastq.gzzr17924_164V1V3_R2.fastq.gz


F17924.S165original sample ID herezr17924_165V1V3_R1.fastq.gzzr17924_165V1V3_R2.fastq.gz


F17924.S166original sample ID herezr17924_166V1V3_R1.fastq.gzzr17924_166V1V3_R2.fastq.gz


F17924.S167original sample ID herezr17924_167V1V3_R1.fastq.gzzr17924_167V1V3_R2.fastq.gz


F17924.S168original sample ID herezr17924_168V1V3_R1.fastq.gzzr17924_168V1V3_R2.fastq.gz


F17924.S169original sample ID herezr17924_169V1V3_R1.fastq.gzzr17924_169V1V3_R2.fastq.gz


F17924.S016original sample ID herezr17924_16V1V3_R1.fastq.gzzr17924_16V1V3_R2.fastq.gz


F17924.S170original sample ID herezr17924_170V1V3_R1.fastq.gzzr17924_170V1V3_R2.fastq.gz


F17924.S171original sample ID herezr17924_171V1V3_R1.fastq.gzzr17924_171V1V3_R2.fastq.gz


F17924.S172original sample ID herezr17924_172V1V3_R1.fastq.gzzr17924_172V1V3_R2.fastq.gz


F17924.S173original sample ID herezr17924_173V1V3_R1.fastq.gzzr17924_173V1V3_R2.fastq.gz


F17924.S174original sample ID herezr17924_174V1V3_R1.fastq.gzzr17924_174V1V3_R2.fastq.gz


F17924.S175original sample ID herezr17924_175V1V3_R1.fastq.gzzr17924_175V1V3_R2.fastq.gz


F17924.S176original sample ID herezr17924_176V1V3_R1.fastq.gzzr17924_176V1V3_R2.fastq.gz


F17924.S177original sample ID herezr17924_177V1V3_R1.fastq.gzzr17924_177V1V3_R2.fastq.gz


F17924.S178original sample ID herezr17924_178V1V3_R1.fastq.gzzr17924_178V1V3_R2.fastq.gz


F17924.S179original sample ID herezr17924_179V1V3_R1.fastq.gzzr17924_179V1V3_R2.fastq.gz


F17924.S017original sample ID herezr17924_17V1V3_R1.fastq.gzzr17924_17V1V3_R2.fastq.gz


F17924.S180original sample ID herezr17924_180V1V3_R1.fastq.gzzr17924_180V1V3_R2.fastq.gz


F17924.S181original sample ID herezr17924_181V1V3_R1.fastq.gzzr17924_181V1V3_R2.fastq.gz


F17924.S182original sample ID herezr17924_182V1V3_R1.fastq.gzzr17924_182V1V3_R2.fastq.gz


F17924.S183original sample ID herezr17924_183V1V3_R1.fastq.gzzr17924_183V1V3_R2.fastq.gz


F17924.S184original sample ID herezr17924_184V1V3_R1.fastq.gzzr17924_184V1V3_R2.fastq.gz


F17924.S185original sample ID herezr17924_185V1V3_R1.fastq.gzzr17924_185V1V3_R2.fastq.gz


F17924.S186original sample ID herezr17924_186V1V3_R1.fastq.gzzr17924_186V1V3_R2.fastq.gz


F17924.S187original sample ID herezr17924_187V1V3_R1.fastq.gzzr17924_187V1V3_R2.fastq.gz


F17924.S188original sample ID herezr17924_188V1V3_R1.fastq.gzzr17924_188V1V3_R2.fastq.gz


F17924.S189original sample ID herezr17924_189V1V3_R1.fastq.gzzr17924_189V1V3_R2.fastq.gz


F17924.S018original sample ID herezr17924_18V1V3_R1.fastq.gzzr17924_18V1V3_R2.fastq.gz


F17924.S190original sample ID herezr17924_190V1V3_R1.fastq.gzzr17924_190V1V3_R2.fastq.gz


F17924.S191original sample ID herezr17924_191V1V3_R1.fastq.gzzr17924_191V1V3_R2.fastq.gz


F17924.S192original sample ID herezr17924_192V1V3_R1.fastq.gzzr17924_192V1V3_R2.fastq.gz


F17924.S193original sample ID herezr17924_193V1V3_R1.fastq.gzzr17924_193V1V3_R2.fastq.gz


F17924.S194original sample ID herezr17924_194V1V3_R1.fastq.gzzr17924_194V1V3_R2.fastq.gz


F17924.S195original sample ID herezr17924_195V1V3_R1.fastq.gzzr17924_195V1V3_R2.fastq.gz


F17924.S196original sample ID herezr17924_196V1V3_R1.fastq.gzzr17924_196V1V3_R2.fastq.gz


F17924.S197original sample ID herezr17924_197V1V3_R1.fastq.gzzr17924_197V1V3_R2.fastq.gz


F17924.S198original sample ID herezr17924_198V1V3_R1.fastq.gzzr17924_198V1V3_R2.fastq.gz


F17924.S199original sample ID herezr17924_199V1V3_R1.fastq.gzzr17924_199V1V3_R2.fastq.gz


F17924.S019original sample ID herezr17924_19V1V3_R1.fastq.gzzr17924_19V1V3_R2.fastq.gz


F17924.S001original sample ID herezr17924_1V1V3_R1.fastq.gzzr17924_1V1V3_R2.fastq.gz


F17924.S200original sample ID herezr17924_200V1V3_R1.fastq.gzzr17924_200V1V3_R2.fastq.gz


F17924.S201original sample ID herezr17924_201V1V3_R1.fastq.gzzr17924_201V1V3_R2.fastq.gz


F17924.S202original sample ID herezr17924_202V1V3_R1.fastq.gzzr17924_202V1V3_R2.fastq.gz


F17924.S203original sample ID herezr17924_203V1V3_R1.fastq.gzzr17924_203V1V3_R2.fastq.gz


F17924.S204original sample ID herezr17924_204V1V3_R1.fastq.gzzr17924_204V1V3_R2.fastq.gz


F17924.S205original sample ID herezr17924_205V1V3_R1.fastq.gzzr17924_205V1V3_R2.fastq.gz


F17924.S206original sample ID herezr17924_206V1V3_R1.fastq.gzzr17924_206V1V3_R2.fastq.gz


F17924.S207original sample ID herezr17924_207V1V3_R1.fastq.gzzr17924_207V1V3_R2.fastq.gz


F17924.S208original sample ID herezr17924_208V1V3_R1.fastq.gzzr17924_208V1V3_R2.fastq.gz


F17924.S209original sample ID herezr17924_209V1V3_R1.fastq.gzzr17924_209V1V3_R2.fastq.gz


F17924.S020original sample ID herezr17924_20V1V3_R1.fastq.gzzr17924_20V1V3_R2.fastq.gz


F17924.S210original sample ID herezr17924_210V1V3_R1.fastq.gzzr17924_210V1V3_R2.fastq.gz


F17924.S211original sample ID herezr17924_211V1V3_R1.fastq.gzzr17924_211V1V3_R2.fastq.gz


F17924.S212original sample ID herezr17924_212V1V3_R1.fastq.gzzr17924_212V1V3_R2.fastq.gz


F17924.S213original sample ID herezr17924_213V1V3_R1.fastq.gzzr17924_213V1V3_R2.fastq.gz


F17924.S214original sample ID herezr17924_214V1V3_R1.fastq.gzzr17924_214V1V3_R2.fastq.gz


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F17924.S370original sample ID herezr17924_370V1V3_R1.fastq.gzzr17924_370V1V3_R2.fastq.gz


F17924.S371original sample ID herezr17924_371V1V3_R1.fastq.gzzr17924_371V1V3_R2.fastq.gz


F17924.S372original sample ID herezr17924_372V1V3_R1.fastq.gzzr17924_372V1V3_R2.fastq.gz


F17924.S373original sample ID herezr17924_373V1V3_R1.fastq.gzzr17924_373V1V3_R2.fastq.gz


F17924.S374original sample ID herezr17924_374V1V3_R1.fastq.gzzr17924_374V1V3_R2.fastq.gz


F17924.S375original sample ID herezr17924_375V1V3_R1.fastq.gzzr17924_375V1V3_R2.fastq.gz


F17924.S376original sample ID herezr17924_376V1V3_R1.fastq.gzzr17924_376V1V3_R2.fastq.gz


F17924.S377original sample ID herezr17924_377V1V3_R1.fastq.gzzr17924_377V1V3_R2.fastq.gz


F17924.S378original sample ID herezr17924_378V1V3_R1.fastq.gzzr17924_378V1V3_R2.fastq.gz


F17924.S379original sample ID herezr17924_379V1V3_R1.fastq.gzzr17924_379V1V3_R2.fastq.gz


F17924.S037original sample ID herezr17924_37V1V3_R1.fastq.gzzr17924_37V1V3_R2.fastq.gz


F17924.S380original sample ID herezr17924_380V1V3_R1.fastq.gzzr17924_380V1V3_R2.fastq.gz


F17924.S381original sample ID herezr17924_381V1V3_R1.fastq.gzzr17924_381V1V3_R2.fastq.gz


F17924.S382original sample ID herezr17924_382V1V3_R1.fastq.gzzr17924_382V1V3_R2.fastq.gz


F17924.S383original sample ID herezr17924_383V1V3_R1.fastq.gzzr17924_383V1V3_R2.fastq.gz


F17924.S384original sample ID herezr17924_384V1V3_R1.fastq.gzzr17924_384V1V3_R2.fastq.gz


F17924.S385original sample ID herezr17924_385V1V3_R1.fastq.gzzr17924_385V1V3_R2.fastq.gz


F17924.S386original sample ID herezr17924_386V1V3_R1.fastq.gzzr17924_386V1V3_R2.fastq.gz


F17924.S387original sample ID herezr17924_387V1V3_R1.fastq.gzzr17924_387V1V3_R2.fastq.gz


F17924.S388original sample ID herezr17924_388V1V3_R1.fastq.gzzr17924_388V1V3_R2.fastq.gz


F17924.S389original sample ID herezr17924_389V1V3_R1.fastq.gzzr17924_389V1V3_R2.fastq.gz


F17924.S038original sample ID herezr17924_38V1V3_R1.fastq.gzzr17924_38V1V3_R2.fastq.gz


F17924.S390original sample ID herezr17924_390V1V3_R1.fastq.gzzr17924_390V1V3_R2.fastq.gz


F17924.S391original sample ID herezr17924_391V1V3_R1.fastq.gzzr17924_391V1V3_R2.fastq.gz


F17924.S392original sample ID herezr17924_392V1V3_R1.fastq.gzzr17924_392V1V3_R2.fastq.gz


F17924.S393original sample ID herezr17924_393V1V3_R1.fastq.gzzr17924_393V1V3_R2.fastq.gz


F17924.S394original sample ID herezr17924_394V1V3_R1.fastq.gzzr17924_394V1V3_R2.fastq.gz


F17924.S395original sample ID herezr17924_395V1V3_R1.fastq.gzzr17924_395V1V3_R2.fastq.gz


F17924.S396original sample ID herezr17924_396V1V3_R1.fastq.gzzr17924_396V1V3_R2.fastq.gz


F17924.S397original sample ID herezr17924_397V1V3_R1.fastq.gzzr17924_397V1V3_R2.fastq.gz


F17924.S398original sample ID herezr17924_398V1V3_R1.fastq.gzzr17924_398V1V3_R2.fastq.gz


F17924.S399original sample ID herezr17924_399V1V3_R1.fastq.gzzr17924_399V1V3_R2.fastq.gz


F17924.S039original sample ID herezr17924_39V1V3_R1.fastq.gzzr17924_39V1V3_R2.fastq.gz


F17924.S003original sample ID herezr17924_3V1V3_R1.fastq.gzzr17924_3V1V3_R2.fastq.gz


F17924.S400original sample ID herezr17924_400V1V3_R1.fastq.gzzr17924_400V1V3_R2.fastq.gz


F17924.S401original sample ID herezr17924_401V1V3_R1.fastq.gzzr17924_401V1V3_R2.fastq.gz


F17924.S402original sample ID herezr17924_402V1V3_R1.fastq.gzzr17924_402V1V3_R2.fastq.gz


F17924.S403original sample ID herezr17924_403V1V3_R1.fastq.gzzr17924_403V1V3_R2.fastq.gz


F17924.S404original sample ID herezr17924_404V1V3_R1.fastq.gzzr17924_404V1V3_R2.fastq.gz


F17924.S405original sample ID herezr17924_405V1V3_R1.fastq.gzzr17924_405V1V3_R2.fastq.gz


F17924.S406original sample ID herezr17924_406V1V3_R1.fastq.gzzr17924_406V1V3_R2.fastq.gz


F17924.S407original sample ID herezr17924_407V1V3_R1.fastq.gzzr17924_407V1V3_R2.fastq.gz


F17924.S408original sample ID herezr17924_408V1V3_R1.fastq.gzzr17924_408V1V3_R2.fastq.gz


F17924.S040original sample ID herezr17924_40V1V3_R1.fastq.gzzr17924_40V1V3_R2.fastq.gz


F17924.S041original sample ID herezr17924_41V1V3_R1.fastq.gzzr17924_41V1V3_R2.fastq.gz


F17924.S042original sample ID herezr17924_42V1V3_R1.fastq.gzzr17924_42V1V3_R2.fastq.gz


F17924.S043original sample ID herezr17924_43V1V3_R1.fastq.gzzr17924_43V1V3_R2.fastq.gz


F17924.S044original sample ID herezr17924_44V1V3_R1.fastq.gzzr17924_44V1V3_R2.fastq.gz


F17924.S045original sample ID herezr17924_45V1V3_R1.fastq.gzzr17924_45V1V3_R2.fastq.gz


F17924.S046original sample ID herezr17924_46V1V3_R1.fastq.gzzr17924_46V1V3_R2.fastq.gz


F17924.S047original sample ID herezr17924_47V1V3_R1.fastq.gzzr17924_47V1V3_R2.fastq.gz


F17924.S048original sample ID herezr17924_48V1V3_R1.fastq.gzzr17924_48V1V3_R2.fastq.gz


F17924.S049original sample ID herezr17924_49V1V3_R1.fastq.gzzr17924_49V1V3_R2.fastq.gz


F17924.S004original sample ID herezr17924_4V1V3_R1.fastq.gzzr17924_4V1V3_R2.fastq.gz


F17924.S050original sample ID herezr17924_50V1V3_R1.fastq.gzzr17924_50V1V3_R2.fastq.gz


F17924.S051original sample ID herezr17924_51V1V3_R1.fastq.gzzr17924_51V1V3_R2.fastq.gz


F17924.S052original sample ID herezr17924_52V1V3_R1.fastq.gzzr17924_52V1V3_R2.fastq.gz


F17924.S053original sample ID herezr17924_53V1V3_R1.fastq.gzzr17924_53V1V3_R2.fastq.gz


F17924.S054original sample ID herezr17924_54V1V3_R1.fastq.gzzr17924_54V1V3_R2.fastq.gz


F17924.S055original sample ID herezr17924_55V1V3_R1.fastq.gzzr17924_55V1V3_R2.fastq.gz


F17924.S056original sample ID herezr17924_56V1V3_R1.fastq.gzzr17924_56V1V3_R2.fastq.gz


F17924.S057original sample ID herezr17924_57V1V3_R1.fastq.gzzr17924_57V1V3_R2.fastq.gz


F17924.S058original sample ID herezr17924_58V1V3_R1.fastq.gzzr17924_58V1V3_R2.fastq.gz


F17924.S059original sample ID herezr17924_59V1V3_R1.fastq.gzzr17924_59V1V3_R2.fastq.gz


F17924.S005original sample ID herezr17924_5V1V3_R1.fastq.gzzr17924_5V1V3_R2.fastq.gz


F17924.S060original sample ID herezr17924_60V1V3_R1.fastq.gzzr17924_60V1V3_R2.fastq.gz


F17924.S061original sample ID herezr17924_61V1V3_R1.fastq.gzzr17924_61V1V3_R2.fastq.gz


F17924.S062original sample ID herezr17924_62V1V3_R1.fastq.gzzr17924_62V1V3_R2.fastq.gz


F17924.S063original sample ID herezr17924_63V1V3_R1.fastq.gzzr17924_63V1V3_R2.fastq.gz


F17924.S064original sample ID herezr17924_64V1V3_R1.fastq.gzzr17924_64V1V3_R2.fastq.gz


F17924.S065original sample ID herezr17924_65V1V3_R1.fastq.gzzr17924_65V1V3_R2.fastq.gz


F17924.S066original sample ID herezr17924_66V1V3_R1.fastq.gzzr17924_66V1V3_R2.fastq.gz


F17924.S067original sample ID herezr17924_67V1V3_R1.fastq.gzzr17924_67V1V3_R2.fastq.gz


F17924.S068original sample ID herezr17924_68V1V3_R1.fastq.gzzr17924_68V1V3_R2.fastq.gz


F17924.S069original sample ID herezr17924_69V1V3_R1.fastq.gzzr17924_69V1V3_R2.fastq.gz


F17924.S006original sample ID herezr17924_6V1V3_R1.fastq.gzzr17924_6V1V3_R2.fastq.gz


F17924.S070original sample ID herezr17924_70V1V3_R1.fastq.gzzr17924_70V1V3_R2.fastq.gz


F17924.S071original sample ID herezr17924_71V1V3_R1.fastq.gzzr17924_71V1V3_R2.fastq.gz


F17924.S072original sample ID herezr17924_72V1V3_R1.fastq.gzzr17924_72V1V3_R2.fastq.gz


F17924.S073original sample ID herezr17924_73V1V3_R1.fastq.gzzr17924_73V1V3_R2.fastq.gz


F17924.S074original sample ID herezr17924_74V1V3_R1.fastq.gzzr17924_74V1V3_R2.fastq.gz


F17924.S075original sample ID herezr17924_75V1V3_R1.fastq.gzzr17924_75V1V3_R2.fastq.gz


F17924.S076original sample ID herezr17924_76V1V3_R1.fastq.gzzr17924_76V1V3_R2.fastq.gz


F17924.S077original sample ID herezr17924_77V1V3_R1.fastq.gzzr17924_77V1V3_R2.fastq.gz


F17924.S078original sample ID herezr17924_78V1V3_R1.fastq.gzzr17924_78V1V3_R2.fastq.gz


F17924.S079original sample ID herezr17924_79V1V3_R1.fastq.gzzr17924_79V1V3_R2.fastq.gz


F17924.S007original sample ID herezr17924_7V1V3_R1.fastq.gzzr17924_7V1V3_R2.fastq.gz


F17924.S080original sample ID herezr17924_80V1V3_R1.fastq.gzzr17924_80V1V3_R2.fastq.gz


F17924.S081original sample ID herezr17924_81V1V3_R1.fastq.gzzr17924_81V1V3_R2.fastq.gz


F17924.S082original sample ID herezr17924_82V1V3_R1.fastq.gzzr17924_82V1V3_R2.fastq.gz


F17924.S083original sample ID herezr17924_83V1V3_R1.fastq.gzzr17924_83V1V3_R2.fastq.gz


F17924.S084original sample ID herezr17924_84V1V3_R1.fastq.gzzr17924_84V1V3_R2.fastq.gz


F17924.S085original sample ID herezr17924_85V1V3_R1.fastq.gzzr17924_85V1V3_R2.fastq.gz


F17924.S086original sample ID herezr17924_86V1V3_R1.fastq.gzzr17924_86V1V3_R2.fastq.gz


F17924.S087original sample ID herezr17924_87V1V3_R1.fastq.gzzr17924_87V1V3_R2.fastq.gz


F17924.S088original sample ID herezr17924_88V1V3_R1.fastq.gzzr17924_88V1V3_R2.fastq.gz


F17924.S089original sample ID herezr17924_89V1V3_R1.fastq.gzzr17924_89V1V3_R2.fastq.gz


F17924.S008original sample ID herezr17924_8V1V3_R1.fastq.gzzr17924_8V1V3_R2.fastq.gz


F17924.S090original sample ID herezr17924_90V1V3_R1.fastq.gzzr17924_90V1V3_R2.fastq.gz


F17924.S091original sample ID herezr17924_91V1V3_R1.fastq.gzzr17924_91V1V3_R2.fastq.gz


F17924.S092original sample ID herezr17924_92V1V3_R1.fastq.gzzr17924_92V1V3_R2.fastq.gz


F17924.S093original sample ID herezr17924_93V1V3_R1.fastq.gzzr17924_93V1V3_R2.fastq.gz


F17924.S094original sample ID herezr17924_94V1V3_R1.fastq.gzzr17924_94V1V3_R2.fastq.gz


F17924.S095original sample ID herezr17924_95V1V3_R1.fastq.gzzr17924_95V1V3_R2.fastq.gz


F17924.S096original sample ID herezr17924_96V1V3_R1.fastq.gzzr17924_96V1V3_R2.fastq.gz


F17924.S097original sample ID herezr17924_97V1V3_R1.fastq.gzzr17924_97V1V3_R2.fastq.gz


F17924.S098original sample ID herezr17924_98V1V3_R1.fastq.gzzr17924_98V1V3_R2.fastq.gz


F17924.S099original sample ID herezr17924_99V1V3_R1.fastq.gzzr17924_99V1V3_R2.fastq.gz


F17924.S009original sample ID herezr17924_9V1V3_R1.fastq.gzzr17924_9V1V3_R2.fastq.gz

Please download and save the file to your computer storage device. The download link will expire after 60 days upon your receiving of this report.

Raw sequence data download link:

 

VI. Analysis - DADA2 Read Processing

What is DADA2?

DADA2 is a software package that models and corrects Illumina-sequenced amplicon errors. DADA2 infers sample sequences exactly, without coarse-graining into OTUs, and resolves differences of as little as one nucleotide. DADA2 identified more real variants and output fewer spurious sequences than other methods.

DADA2’s advantage is that it uses more of the data. The DADA2 error model incorporates quality information, which is ignored by all other methods after filtering. The DADA2 error model incorporates quantitative abundances, whereas most other methods use abundance ranks if they use abundance at all. The DADA2 error model identifies the differences between sequences, eg. A->C, whereas other methods merely count the mismatches. DADA2 can parameterize its error model from the data itself, rather than relying on previous datasets that may or may not reflect the PCR and sequencing protocols used in your study.

DADA2 Publication: Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP. DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods. 2016 Jul;13(7):581-3. doi: 10.1038/nmeth.3869. Epub 2016 May 23. PMID: 27214047; PMCID: PMC4927377.

DADA2 Software Package is available as an R package at : https://benjjneb.github.io/dada2/index.html

Analysis Procedures:

DADA2 pipeline includes several tools for read quality control, including quality filtering, trimming, denoising, pair merging and chimera filtering. Below are the major processing steps of DADA2:

Step 1. Read trimming based on sequence quality The quality of NGS Illumina sequences often decreases toward the end of the reads. DADA2 allows to trim off the poor quality read ends in order to improve the error model building and pair mergicing performance.

Step 2. Learn the Error Rates The DADA2 algorithm makes use of a parametric error model (err) and every amplicon dataset has a different set of error rates. The learnErrors method learns this error model from the data, by alternating estimation of the error rates and inference of sample composition until they converge on a jointly consistent solution. As in many machine-learning problems, the algorithm must begin with an initial guess, for which the maximum possible error rates in this data are used (the error rates if only the most abundant sequence is correct and all the rest are errors).

Step 3. Infer amplicon sequence variants (ASVs) based on the error model built in previous step. This step is also called sequence "denoising". The outcome of this step is a list of ASVs that are the equivalent of oligonucleotides.

Step 4. Merge paired reads. If the sequencing products are read pairs, DADA2 will merge the R1 and R2 ASVs into single sequences. Merging is performed by aligning the denoised forward reads with the reverse-complement of the corresponding denoised reverse reads, and then constructing the merged “contig” sequences. By default, merged sequences are only output if the forward and reverse reads overlap by at least 12 bases, and are identical to each other in the overlap region (but these conditions can be changed via function arguments).

Step 5. Remove chimera. The core dada method corrects substitution and indel errors, but chimeras remain. Fortunately, the accuracy of sequence variants after denoising makes identifying chimeric ASVs simpler than when dealing with fuzzy OTUs. Chimeric sequences are identified if they can be exactly reconstructed by combining a left-segment and a right-segment from two more abundant “parent” sequences. The frequency of chimeric sequences varies substantially from dataset to dataset, and depends on on factors including experimental procedures and sample complexity.

Results

1. Read Quality Plots NGS sequence analaysis starts with visualizing the quality of the sequencing. Below are the quality plots of the first sample for the R1 and R2 reads separately. In gray-scale is a heat map of the frequency of each quality score at each base position. The mean quality score at each position is shown by the green line, and the quartiles of the quality score distribution by the orange lines. The forward reads are usually of better quality. It is a common practice to trim the last few nucleotides to avoid less well-controlled errors that can arise there. The trimming affects the downstream steps including error model building, merging and chimera calling. FOMC uses an empirical approach to test many combinations of different trim length in order to achieve best final amplicon sequence variants (ASVs), see the next section “Optimal trim length for ASVs”.

Quality plots for all samples:

2. Optimal trim length for ASVs The final number of merged and chimera-filtered ASVs depends on the quality filtering (hence trimming) in the very beginning of the DADA2 pipeline. In order to achieve highest number of ASVs, an empirical approach was used -

  1. Create a random subset of each sample consisting of 5,000 R1 and 5,000 R2 (to reduce computation time)
  2. Trim 10 bases at a time from the ends of both R1 and R2 up to 50 bases
  3. For each combination of trimmed length (e.g., 300x300, 300x290, 290x290 etc), the trimmed reads are subject to the entire DADA2 pipeline for chimera-filtered merged ASVs
  4. The combination with highest percentage of the input reads becoming final ASVs is selected for the complete set of data

Below is the result of such operation, showing ASV percentages of total reads for all trimming combinations (1st Column = R1 lengths in bases; 1st Row = R2 lengths in bases):

R1/R2281271261251241231
32174.00%74.53%74.80%75.32%75.51%68.69%
31174.03%74.60%74.87%75.04%68.67%44.01%
30174.08%74.65%74.55%68.18%44.01%21.78%
29174.13%74.34%67.73%43.48%21.75%14.60%
28173.96%67.63%43.40%21.46%14.56%6.26%
27167.53%43.65%21.42%14.28%6.24%3.16%

Based on the above result, the trim length combination of R1 = 321 bases and R2 = 241 bases (highlighted red above), was chosen for generating final ASVs for all sequences. This combination generated highest number of merged non-chimeric ASVs and was used for downstream analyses, if requested.

3. Error plots from learning the error rates After DADA2 building the error model for the set of data, it is always worthwhile, as a sanity check if nothing else, to visualize the estimated error rates. The error rates for each possible transition (A→C, A→G, …) are shown below. Points are the observed error rates for each consensus quality score. The black line shows the estimated error rates after convergence of the machine-learning algorithm. The red line shows the error rates expected under the nominal definition of the Q-score. The ideal result would be the estimated error rates (black line) are a good fit to the observed rates (points), and the error rates drop with increased quality as expected.

Forward Read R1 Error Plot


Reverse Read R2 Error Plot

The PDF version of these plots are available here:

 

4. DADA2 Result Summary The table below shows the summary of the DADA2 analysis, tracking paired read counts of each samples for all the steps during DADA2 denoising process - including end-trimming (filtered), denoising (denoisedF, denoisedF), pair merging (merged) and chimera removal (nonchim).

Sample IDF17924.S001F17924.S002F17924.S003F17924.S004F17924.S005F17924.S006F17924.S007F17924.S008F17924.S009F17924.S010F17924.S011F17924.S012F17924.S013F17924.S014F17924.S015F17924.S016F17924.S017F17924.S018F17924.S019F17924.S020F17924.S021F17924.S022F17924.S023F17924.S024F17924.S025F17924.S026F17924.S027F17924.S028F17924.S029F17924.S030F17924.S031F17924.S032F17924.S033F17924.S034F17924.S035F17924.S036F17924.S037F17924.S038F17924.S039F17924.S040F17924.S041F17924.S042F17924.S043F17924.S044F17924.S045F17924.S046F17924.S047F17924.S048F17924.S049F17924.S050F17924.S051F17924.S052F17924.S053F17924.S054F17924.S055F17924.S056F17924.S057F17924.S058F17924.S059F17924.S060F17924.S061F17924.S062F17924.S063F17924.S064F17924.S065F17924.S066F17924.S067F17924.S068F17924.S069F17924.S070F17924.S071F17924.S072F17924.S073F17924.S074F17924.S075F17924.S076F17924.S077F17924.S078F17924.S079F17924.S080F17924.S081F17924.S082F17924.S083F17924.S084F17924.S085F17924.S086F17924.S087F17924.S088F17924.S089F17924.S090F17924.S091F17924.S092F17924.S093F17924.S094F17924.S095F17924.S096F17924.S097F17924.S098F17924.S099F17924.S100F17924.S101F17924.S102F17924.S103F17924.S104F17924.S105F17924.S106F17924.S107F17924.S108F17924.S109F17924.S110F17924.S111F17924.S112F17924.S113F17924.S114F17924.S115F17924.S116F17924.S117F17924.S118F17924.S119F17924.S120F17924.S121F17924.S122F17924.S123F17924.S124F17924.S125F17924.S126F17924.S127F17924.S128F17924.S129F17924.S130F17924.S131F17924.S132F17924.S133F17924.S134F17924.S135F17924.S136F17924.S137F17924.S138F17924.S139F17924.S140F17924.S141F17924.S142F17924.S143F17924.S144F17924.S145F17924.S146F17924.S147F17924.S148F17924.S149F17924.S150F17924.S151F17924.S152F17924.S153F17924.S154F17924.S155F17924.S156F17924.S157F17924.S158F17924.S159F17924.S160F17924.S161F17924.S162F17924.S163F17924.S164F17924.S165F17924.S166F17924.S167F17924.S168F17924.S169F17924.S170F17924.S171F17924.S172F17924.S173F17924.S174F17924.S175F17924.S176F17924.S177F17924.S178F17924.S179F17924.S180F17924.S181F17924.S182F17924.S183F17924.S184F17924.S185F17924.S186F17924.S187F17924.S188F17924.S189F17924.S190F17924.S191F17924.S192F17924.S193F17924.S194F17924.S195F17924.S196F17924.S197F17924.S198F17924.S199F17924.S200F17924.S201F17924.S202F17924.S203F17924.S204F17924.S205F17924.S206F17924.S207F17924.S208F17924.S209F17924.S210F17924.S211F17924.S212F17924.S213F17924.S214F17924.S215F17924.S216F17924.S217F17924.S218F17924.S219F17924.S220F17924.S221F17924.S222F17924.S223F17924.S224F17924.S225F17924.S226F17924.S227F17924.S228F17924.S229F17924.S230F17924.S231F17924.S232F17924.S233F17924.S234F17924.S235F17924.S236F17924.S237F17924.S238F17924.S239F17924.S240F17924.S241F17924.S242F17924.S243F17924.S244F17924.S245F17924.S246F17924.S247F17924.S248F17924.S249F17924.S250F17924.S251F17924.S252F17924.S253F17924.S254F17924.S255F17924.S256F17924.S257F17924.S258F17924.S259F17924.S260F17924.S261F17924.S262F17924.S263F17924.S264F17924.S265F17924.S266F17924.S267F17924.S268F17924.S269F17924.S270F17924.S271F17924.S272F17924.S273F17924.S274F17924.S275F17924.S276F17924.S277F17924.S278F17924.S279F17924.S280F17924.S281F17924.S282F17924.S283F17924.S284F17924.S285F17924.S286F17924.S287F17924.S288F17924.S289F17924.S290F17924.S291F17924.S292F17924.S293F17924.S294F17924.S295F17924.S296F17924.S297F17924.S298F17924.S299F17924.S300F17924.S301F17924.S302F17924.S303F17924.S304F17924.S305F17924.S306F17924.S307F17924.S308F17924.S309F17924.S310F17924.S311F17924.S312F17924.S313F17924.S314F17924.S315F17924.S316F17924.S317F17924.S318F17924.S319F17924.S320F17924.S321F17924.S322F17924.S323F17924.S324F17924.S325F17924.S326F17924.S327F17924.S328F17924.S329F17924.S330F17924.S331F17924.S332F17924.S333F17924.S334F17924.S335F17924.S336F17924.S337F17924.S338F17924.S339F17924.S340F17924.S341F17924.S342F17924.S343F17924.S344F17924.S345F17924.S346F17924.S347F17924.S348F17924.S349F17924.S350F17924.S351F17924.S352F17924.S353F17924.S354F17924.S355F17924.S356F17924.S357F17924.S358F17924.S359F17924.S360F17924.S361F17924.S362F17924.S363F17924.S364F17924.S365F17924.S366F17924.S367F17924.S368F17924.S369F17924.S370F17924.S371F17924.S372F17924.S373F17924.S374F17924.S375F17924.S376F17924.S377F17924.S378F17924.S379F17924.S380F17924.S381F17924.S382F17924.S383F17924.S384F17924.S385F17924.S386F17924.S387F17924.S388F17924.S389F17924.S390F17924.S391F17924.S392F17924.S393F17924.S394F17924.S395F17924.S396F17924.S397F17924.S398F17924.S399F17924.S400F17924.S401F17924.S402F17924.S403F17924.S404F17924.S405F17924.S406F17924.S407F17924.S408Row SumPercentage
input166,864251,140224,605225,087242,271245,083209,711206,876156,450202,306157,916227,511225,603225,927200,250243,211179,671168,844172,727204,936274,861271,402180,223233,399140,073250,807203,045256,470219,854228,848133,056176,309185,330193,158227,804236,999213,229264,409161,192212,928208,375184,628217,372240,972242,890200,469192,014277,619208,236216,563269,403235,506275,799227,620213,811235,024251,504216,900237,868238,574181,886196,226292,767229,157262,425266,791372,963259,467143,319196,262288,223212,664251,151237,603206,339188,106229,171215,748216,312285,717232,693246,032261,028216,957200,491251,107223,937196,916155,401265,363223,237218,024277,443214,080180,490179,018204,273211,155218,984176,939171,483168,375214,374177,624218,601194,003247,031195,795199,596207,236218,484249,829192,141204,556213,359216,481195,895226,042215,761200,772271,301241,455221,665209,021225,124217,083176,451217,999213,392200,211254,774206,281215,933228,989204,462204,032284,760217,118230,050221,934221,170184,441235,884188,539224,683207,753221,962234,904206,074203,029216,589210,573221,995215,424185,901239,090188,616219,588259,518212,459246,128188,751192,612210,360256,381253,031213,970265,285222,136171,099216,066227,639221,346186,346215,314226,772220,896207,354210,439190,139261,608306,879264,768214,648265,637246,448214,977200,113221,123163,908196,201181,817143,029206,034145,165235,832203,530159,334222,154203,336187,942210,383213,408154,526224,225235,966137,295199,267176,792164,342267,734192,530172,196161,945182,672211,462173,042203,203229,915198,026199,663219,610227,320172,967206,076206,999259,690192,884179,050246,810238,951201,987244,353208,392241,337228,153251,426310,366198,219259,291208,573200,609255,940207,633237,844163,018158,367244,201122,836164,384265,172214,296203,461163,957179,859200,718227,472214,322193,110202,959227,759302,944191,145217,002202,570234,959211,140250,741205,105234,127247,814187,496340,993216,744201,080274,973254,654217,199182,560162,823240,887246,588228,093209,454187,503193,006174,992206,619188,208189,972191,570212,466227,171182,692166,158212,887204,164163,006195,163193,247190,621169,200186,513204,413189,385201,718215,203170,717231,882216,358259,265192,317204,895188,248190,479173,412184,484173,829237,393250,621259,310237,627230,207203,535203,164227,437182,374196,890231,028236,897156,702192,701203,810200,608211,033160,579224,918178,312170,767200,666178,799182,551220,317221,938187,448159,511228,085203,621194,082187,093180,387261,38397,104147,510121,095124,570245,783156,52282,434142,204154,043190,189164,279149,906150,930186,528154,783140,28792,530179,79398,993137,533172,799161,888134,73969,956169,388168,167243,152164,003127,87564,204165,48767,098153,969145,106107,78094,861145,553142,54775,674210,212137,441131,630183,023145,471101,654174,129174,072138,95778,916170,037101,627209,268154,772117,04990,050151,35683,066,146100.00%
filtered156,688235,934211,302211,090227,882230,232197,006194,386147,022190,077148,136213,587211,929211,891187,824228,808168,861158,592162,164192,538258,185254,937169,310219,482131,586235,436190,834241,094206,624214,716124,802165,723173,776181,215213,986222,840200,421247,820151,006200,155195,553173,420204,138226,333227,909188,414180,178260,584195,564203,346252,983221,111259,087213,568201,154220,460236,162203,659223,504224,137170,886184,367275,035215,505246,480250,607350,569243,980135,055184,176270,555199,588235,600223,044193,874176,874214,754202,714203,023268,511218,700230,987245,183204,090188,623235,743210,138184,786145,769249,078209,719204,646260,939200,807169,241168,158191,899198,340205,801166,185161,160158,216201,526166,910205,187182,821231,854183,867187,267194,537204,966234,876180,386191,801200,610203,505183,768212,308202,726188,344254,472226,813208,246196,228211,184203,861165,629204,766200,195188,251239,071193,443202,547215,130191,918191,700267,765203,719216,160208,462207,875173,231221,602177,112210,688194,922208,437220,694193,352190,510203,448197,288208,447202,484174,545224,213177,040206,219243,577199,694231,194176,898180,934197,928240,690237,930200,770249,207208,507160,671202,783213,638208,116175,147202,431213,215207,473194,865197,530178,039245,857288,412248,723201,482249,222231,342201,869187,895207,576153,795184,391170,339134,392193,774136,389221,743190,983149,759208,818190,596176,455197,963200,357145,130210,783221,952128,738187,074166,346154,368251,516181,055161,502152,246171,570198,678162,361191,081215,978185,968188,003206,157213,568162,430193,645194,570244,240181,093168,046232,176224,682189,943229,772195,778226,560214,468236,024291,780186,351243,821195,548188,339240,201195,202223,227152,895148,837229,365115,769154,424249,263201,181190,901153,950168,829188,557213,706201,177181,093190,724213,571284,530179,769204,072190,586220,605198,312235,592192,476220,048232,969176,098320,573203,259188,901258,798239,000203,838171,356152,880226,568231,972214,077196,790176,347181,442163,966194,069176,678178,571179,990199,422213,479171,431155,785200,018191,876153,045183,404181,496178,941158,836174,890192,010178,197189,488202,130160,346217,816203,130243,935180,587192,566176,921178,638162,496173,464163,142223,005235,577243,719223,235216,128191,345191,091213,790171,176185,281216,842222,649147,045181,214191,404188,713198,186150,848211,028167,652160,363188,590167,966171,384207,300208,916176,382149,891214,109191,197182,529175,691169,367245,70591,155138,331113,636117,123230,747147,19377,239133,489144,646178,522153,884140,720141,783175,227145,201131,47786,877168,99992,812129,175162,469152,126126,57165,495158,889157,843228,424153,933120,16160,231155,51362,980144,482136,373101,18889,046136,895133,85271,039197,559129,191123,703171,980136,76795,476163,586163,638130,56574,217159,42095,311196,348145,248109,90584,455142,06478,019,19193.92%
denoisedF154,615233,876209,395208,520225,621228,320194,865191,978145,402188,018146,549211,111209,478209,607185,889226,531167,371157,087160,849190,238255,317252,338167,585216,774129,965233,633188,772238,560205,193211,966123,557163,946171,870179,486211,598220,314197,975245,113149,109198,033193,134171,534201,697224,434224,869186,598178,173257,019193,938200,903250,111218,328256,799211,804198,498218,307233,788201,353221,188221,860169,113182,331271,807213,162243,695248,255346,827241,033133,659182,533267,124197,207233,034220,656191,691174,885212,521200,491201,499265,032216,042228,651242,449202,062186,967233,620207,356182,320143,599246,349207,211202,020257,224198,592167,659166,133189,740195,989203,020164,534159,050156,198198,538164,932202,975180,520229,136182,081184,736192,271202,663231,979178,108189,329198,526201,065181,417210,004199,994186,330252,292224,264205,651194,139209,124201,772163,518202,439197,904186,477236,063190,879200,268212,453189,926189,992264,656201,744213,600205,736205,518171,206218,486175,137208,148193,334205,705218,186191,177188,125201,815195,225205,751199,671173,051221,860174,785203,715240,107197,286228,811175,469178,857195,548238,005234,533198,391246,412206,274158,442200,694211,532205,436173,007200,283211,143204,621191,954194,712176,111243,609285,205245,791199,291245,929228,422199,780185,545205,134151,727181,858168,417133,215191,108134,918218,847188,713147,786206,144188,287174,184196,204197,928143,541208,713219,622127,456185,202164,487152,876249,426179,545159,751150,665169,694196,475160,366189,201213,979184,314186,122204,321211,796160,813191,951192,555241,607179,536166,258229,610222,848187,991227,313193,888224,544212,155234,050288,988184,004241,310193,188186,770237,741193,433221,160151,326147,306227,484114,530152,964246,552199,231189,240152,553166,953186,609211,724199,404179,059188,534211,898281,992177,947201,695188,740218,039196,010232,956190,635218,272230,693174,665317,740201,851186,626255,902236,408202,257169,581151,138224,056229,957212,547194,576174,754179,585162,179192,115174,530176,856177,951197,189211,438170,190154,579197,717190,396151,658181,776179,722177,264156,917172,983190,495176,617187,600199,914158,652215,963201,058241,390178,696190,812175,647176,583160,758171,141161,556220,459232,987241,313220,885213,698189,628189,425211,714169,316183,114214,534219,941145,649179,232189,640187,186196,065149,139208,920165,468158,857186,167165,560169,719204,183206,642174,311148,328211,691189,142180,615174,217167,413243,54389,993136,770112,388115,803228,119145,22576,215131,996142,970176,256152,414139,162140,374173,714143,382130,03685,740167,06191,529128,060161,073150,289125,54764,520157,143156,152225,875152,160118,59459,387153,92162,295143,258134,72499,80087,901135,327132,31470,104195,563127,636121,951169,933135,46094,476161,572161,870128,80073,511158,04793,813194,037143,297108,65183,291140,42677,172,38792.90%
denoisedR150,408228,181203,739203,097221,507224,253189,916186,907141,917183,062142,670206,282204,319205,227181,827220,954163,932153,287157,479187,030249,714245,672163,586211,097126,612225,800184,601232,870199,121207,250120,378160,166166,828176,017207,625214,280193,658240,436145,341193,532189,137166,879197,963221,300219,891182,091173,100252,056188,540197,169244,913214,096250,665206,103194,255212,579229,326195,957215,331215,811165,418178,241265,758208,855237,498242,495338,418234,419129,966177,667261,810192,379228,710214,962186,983170,494207,440195,286196,284257,782211,482223,878237,504196,456181,030226,863202,388177,971140,125240,166202,124197,046250,764194,323162,802163,083185,286191,199198,507160,275155,588152,067193,540160,772197,222176,541224,062178,806180,046186,908198,732227,864173,638185,073194,528196,776176,998205,141196,104181,572247,268219,733199,747189,535203,734195,411158,415197,830193,641181,540231,746186,014195,000207,793184,786185,808259,423196,741208,695201,369200,174167,110212,656169,664203,152189,925200,511213,681185,524183,723196,373189,717200,713195,489168,443216,371170,684198,205235,453192,072222,505170,124174,589190,499232,204229,527193,123241,071200,978153,967195,636206,152200,469167,948195,536205,526199,494187,410190,134172,522238,478277,890240,387195,055240,486221,853194,662180,803200,177147,998177,791163,843129,682186,458131,342214,020183,771144,996201,422182,695169,743191,784192,856140,345202,670213,689123,445181,783160,347149,030242,911175,059155,803146,303164,592190,987156,540184,821209,049180,765181,574198,936206,252156,478186,528188,404234,998174,947162,674223,831218,182182,757221,852188,878218,630206,767227,784283,504180,752235,900189,032182,422230,763188,628215,253147,504143,258221,160111,119149,103239,027195,432183,325148,528162,415181,170205,826194,529174,336183,603206,276274,285173,518196,573183,819212,425191,054227,963185,742214,100225,847170,314306,952196,142180,916248,690230,826196,169165,757147,119218,007224,623206,886189,767169,778174,734158,039186,529170,437172,691173,421192,859205,828165,233150,905193,000185,042147,051177,848174,349172,423153,094168,994184,752172,859182,814194,741154,425211,478196,286235,266175,241185,331171,418172,403156,554167,074156,958215,102227,931236,576216,815209,022184,873184,948207,839164,528178,977207,881215,648141,468175,034185,567181,837191,500145,581203,700161,690154,608183,068162,478165,817201,029202,112169,598144,847207,066184,953176,037170,618162,985236,81687,577134,288109,252113,215222,529141,71274,122128,250139,438171,710148,987135,627137,543169,071140,122126,84383,513163,52989,001126,038157,846147,721121,83462,449152,564152,249221,439148,321116,34157,854150,12060,779139,600131,17797,40185,655131,855128,42068,549190,928124,529119,182166,308131,61892,617157,520157,983125,99772,061153,86791,336189,728140,434105,06381,131136,89175,293,43890.64%
merged139,971220,334190,160191,221212,666217,232178,751177,023133,381172,576135,271194,354191,934192,957173,180209,626157,280143,371152,720176,943237,831234,615155,708200,422120,407219,322175,183200,733193,524194,500115,361151,849159,552168,825198,096201,332182,029229,449137,368184,183178,045157,919187,042212,109207,066174,152163,691237,310182,965187,124229,571201,816241,577182,627182,075202,498218,621184,616205,434207,158156,623168,786252,582197,652225,541221,877319,530222,288122,897172,149247,100180,136216,452203,649177,806162,890197,891184,341165,121243,770199,494212,362225,753188,611174,532220,158189,517166,942131,345228,200192,949185,640235,031184,679155,814153,612176,223180,389186,313152,708147,093141,663179,318153,489187,483166,271213,606172,015165,966176,817188,690216,565161,682174,801184,452184,580166,141191,350186,069168,218238,292205,634183,274176,784193,808172,384149,562187,117184,801164,990219,484174,334183,335196,848175,126177,295245,733187,087191,005191,176191,117149,498196,725155,254191,787180,857186,913204,495175,807172,185189,561178,557186,485184,202161,116204,848155,326185,329221,264180,600212,010163,896164,172178,741219,763215,329180,754218,976191,638144,054183,163197,974182,369155,081182,722196,588186,853173,255177,544162,962192,336262,209222,682185,051225,049189,016186,403170,372188,243137,946166,545154,209124,136175,070123,146200,231173,442136,495190,349173,564158,453184,532182,145132,352195,220207,122118,650175,372153,627144,387235,719170,237149,992140,674158,124183,844150,140178,351202,169174,750174,305192,912200,094150,609180,071181,849226,683168,939157,216215,407210,933175,416213,332182,413212,383198,758221,246273,777173,385227,550180,383176,114222,221183,328207,853142,019137,983214,238106,937143,323229,965188,514177,293143,448156,436174,602190,943187,571166,916175,586200,004266,002167,518189,730177,061203,540183,696218,700179,008207,863217,673165,339297,917190,321174,066237,453222,589189,931160,152141,141209,071216,542200,029181,860164,311168,132151,659180,562163,279167,093165,511184,921199,241160,689147,153185,932180,032141,678172,850168,278166,138146,358162,518178,664167,402177,064187,162149,167205,065188,357225,841168,554179,209167,081164,848150,480159,865150,369206,802217,896228,050208,982201,254178,340178,993199,731157,213171,724200,272207,235136,670168,602178,727173,987184,536139,825197,154153,856149,378175,675154,975159,719192,176193,558162,770140,102199,045178,172169,169164,810156,420228,03183,672129,109104,844108,982214,668135,97670,125122,722132,746163,230143,714130,791132,801163,520134,403121,56979,451157,09784,363121,982151,684142,596118,46559,493146,095145,106213,459142,478111,70654,894145,48957,986132,391125,57393,20982,280126,140123,20765,177184,770118,431113,350159,760127,51689,384151,041152,523120,38069,713148,49586,426182,255134,027100,42777,490132,05571,651,17686.26%
nonchim127,904190,651169,647170,062181,942194,859157,698157,886122,627151,893120,011172,942175,246182,690156,892179,702143,023128,341130,862159,572225,645203,042137,252178,017105,352183,616155,438168,062172,539183,277100,931135,629136,331155,267180,162187,717171,561216,998128,542171,563167,679135,111176,485195,423187,063149,299140,561213,395157,093168,266217,421190,438200,250158,594171,487181,494205,684162,642183,722179,542148,056153,553228,292187,344205,428186,035284,124193,230106,839152,320215,232165,752208,220178,463157,165145,029179,330163,561135,450218,698186,048196,036205,787162,090144,976185,712170,743156,858123,043199,835172,623171,522199,837171,810138,353143,182161,296165,789169,606138,896130,299130,505160,654130,478171,159156,718198,093158,219152,907164,707178,515201,808152,386154,338173,653174,904154,392175,940173,111149,907212,320182,027168,427161,222179,806154,266129,374176,240167,736137,284208,516159,978172,490182,770149,658165,655228,820173,418171,427185,420169,174135,981182,962135,789177,474170,660168,763180,041155,036159,809170,891165,998178,807172,273142,429179,191147,128164,862210,987166,521199,391134,909157,784163,549207,640197,834161,379190,402178,994131,687169,215166,724170,682142,816171,795183,165170,968161,793163,533152,137169,439246,920210,278177,612201,190164,556159,737149,921174,650122,052157,353138,546116,888164,258112,957186,490158,094128,934170,652154,791147,547165,311168,480121,185167,422179,30399,516157,226128,999125,938204,256133,962127,334117,023137,709164,037124,186159,573171,206156,385156,469167,106155,015133,181155,971163,084187,527145,130137,714182,996187,208142,675183,844149,549190,929169,346188,636248,675151,867204,618159,290157,774164,102153,077178,386118,283120,496186,88388,778121,267187,289170,172148,827124,687126,741149,175164,172161,444136,282154,024176,336228,877139,547156,775157,807177,583159,660192,630141,045182,872190,542145,568230,839151,549145,483198,844192,779163,656138,143122,254169,820195,818165,047158,580145,222143,899127,682138,554134,916146,816144,877170,902168,746126,725128,115156,272157,090118,290151,986145,954140,179128,733147,762151,997149,871147,351161,400122,407182,765166,490192,174153,794157,729137,094143,226125,835142,038132,712179,970190,198195,788192,283174,948151,364148,503184,269139,816152,410168,881176,523109,138145,331161,377139,935163,011117,427170,421132,790126,446161,386137,466147,303177,073173,958132,075115,251182,184161,062149,097152,973129,300185,56175,958122,17592,29997,885194,086118,24564,011110,363119,404143,069131,664117,503119,785148,732122,469111,59871,286144,15373,801113,823137,267129,93193,03652,584131,673133,413196,786124,28396,75747,515130,37853,358105,796108,24782,06873,992111,862104,56659,269169,179105,529102,787145,503108,10578,975125,104138,959107,42965,822135,83374,761172,055122,98790,06369,108111,44863,590,44076.55%

This table can be downloaded as an Excel table below:

 

5. DADA2 Amplicon Sequence Variants (ASVs). A total of 36789 unique merged and chimera-free ASV sequences were identified, and their corresponding read counts for each sample are available in the "ASV Read Count Table" with rows for the ASV sequences and columns for sample. This read count table can be used for microbial profile comparison among different samples and the sequences provided in the table can be used to taxonomy assignment.

 

The table can be downloaded from this link:

 
 

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F17924.S327S327001024SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S328S328001025SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S329S329001026SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S330S330001027SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S331S331001028SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S332S332001029SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S333S333001031SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S334S334001032SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S335S335001033SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S336S336001034SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S337S337001035SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S338S338001037SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S339S339001038SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S340S340001039SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S341S341001041SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S342S342001042SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S343S343001043SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S344S344001044SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S345S345001045SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S346S346001046SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S347S347001047SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S348S348001049SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S349S349001050SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S350S350001051SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S351S351001052SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S352S352001054SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S353S353001055SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S354S354001056SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S355S355001057SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S356S356001058SALV2Product AProduct A V2Product A V2 SALProduct A V2
F17924.S357S357001059SALV2Product BProduct B V2Product B V2 SALProduct B V2
F17924.S358S358001001SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S359S359001002SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S360S360001003SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S361S361001004SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S362S362001005SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S363S363001006SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S364S364001007SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S365S365001008SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S366S366001009SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S367S367001010SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S368S368001011SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S369S369001012SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S370S370001013SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S371S371001014SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S372S372001015SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S373S373001019SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S374S374001020SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S375S375001021SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S376S376001022SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S377S377001023SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S378S378001024SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S379S379001025SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S380S380001026SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S381S381001027SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S382S382001028SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S383S383001029SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S384S384001031SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S385S385001032SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S386S386001033SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S387S387001034SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S388S388001035SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S389S389001037SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S390S390001038SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S391S391001039SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S392S392001041SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S393S393001042SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S394S394001043SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S395S395001044SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S396S396001045SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S397S397001046SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S398S398001047SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S399S399001049SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S400S400001050SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S401S401001051SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S402S402001052SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S403S403001054SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S404S404001055SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S405S405001056SALV3Product BProduct B V3Product B V3 SALProduct B V3
F17924.S406S406001057SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S407S407001058SALV3Product AProduct A V3Product A V3 SALProduct A V3
F17924.S408S408001059SALV3Product BProduct B V3Product B V3 SALProduct B V3
 
 

ASV Read Counts by Samples

#Sample IDRead Count
F17924.S38247,515
F17924.S37652,584
F17924.S38453,358
F17924.S39159,269
F17924.S35964,011
F17924.S40165,822
F17924.S40769,108
F17924.S36971,286
F17924.S37173,801
F17924.S38873,992
F17924.S40374,761
F17924.S35375,958
F17924.S39778,975
F17924.S38782,068
F17924.S24988,778
F17924.S40690,063
F17924.S35592,299
F17924.S37593,036
F17924.S38196,757
F17924.S35697,885
F17924.S20799,516
F17924.S031100,931
F17924.S394102,787
F17924.S390104,566
F17924.S025105,352
F17924.S393105,529
F17924.S385105,796
F17924.S069106,839
F17924.S400107,429
F17924.S396108,105
F17924.S386108,247
F17924.S331109,138
F17924.S360110,363
F17924.S408111,448
F17924.S368111,598
F17924.S389111,862
F17924.S195112,957
F17924.S372113,823
F17924.S346115,251
F17924.S193116,888
F17924.S214117,023
F17924.S336117,427
F17924.S364117,503
F17924.S358118,245
F17924.S246118,283
F17924.S298118,290
F17924.S361119,404
F17924.S365119,785
F17924.S011120,011
F17924.S247120,496
F17924.S204121,185
F17924.S250121,267
F17924.S190122,052
F17924.S354122,175
F17924.S280122,254
F17924.S308122,407
F17924.S367122,469
F17924.S009122,627
F17924.S405122,987
F17924.S089123,043
F17924.S217124,186
F17924.S380124,283
F17924.S254124,687
F17924.S398125,104
F17924.S316125,835
F17924.S210125,938
F17924.S339126,446
F17924.S294126,725
F17924.S255126,741
F17924.S213127,334
F17924.S287127,682
F17924.S001127,904
F17924.S295128,115
F17924.S018128,341
F17924.S039128,542
F17924.S302128,733
F17924.S198128,934
F17924.S209128,999
F17924.S351129,300
F17924.S127129,374
F17924.S374129,931
F17924.S101130,299
F17924.S383130,378
F17924.S104130,478
F17924.S102130,505
F17924.S019130,862
F17924.S363131,664
F17924.S377131,673
F17924.S170131,687
F17924.S345132,075
F17924.S318132,712
F17924.S338132,790
F17924.S224133,181
F17924.S378133,413
F17924.S212133,962
F17924.S162134,909
F17924.S289134,916
F17924.S042135,111
F17924.S079135,450
F17924.S032135,629
F17924.S144135,789
F17924.S402135,833
F17924.S142135,981
F17924.S259136,282
F17924.S033136,331
F17924.S314137,094
F17924.S023137,252
F17924.S373137,267
F17924.S130137,284
F17924.S341137,466
F17924.S215137,709
F17924.S229137,714
F17924.S279138,143
F17924.S095138,353
F17924.S192138,546
F17924.S288138,554
F17924.S100138,896
F17924.S399138,959
F17924.S263139,547
F17924.S327139,816
F17924.S334139,935
F17924.S301140,179
F17924.S047140,561
F17924.S269141,045
F17924.S317142,038
F17924.S155142,429
F17924.S232142,675
F17924.S174142,816
F17924.S017143,023
F17924.S362143,069
F17924.S096143,182
F17924.S315143,226
F17924.S286143,899
F17924.S370144,153
F17924.S291144,877
F17924.S085144,976
F17924.S076145,029
F17924.S228145,130
F17924.S285145,222
F17924.S332145,331
F17924.S275145,483
F17924.S395145,503
F17924.S272145,568
F17924.S300145,954
F17924.S290146,816
F17924.S157147,128
F17924.S342147,303
F17924.S306147,351
F17924.S201147,547
F17924.S303147,762
F17924.S061148,056
F17924.S325148,503
F17924.S366148,732
F17924.S253148,827
F17924.S349149,097
F17924.S256149,175
F17924.S046149,299
F17924.S234149,549
F17924.S135149,658
F17924.S305149,871
F17924.S120149,907
F17924.S188149,921
F17924.S324151,364
F17924.S274151,549
F17924.S239151,867
F17924.S010151,893
F17924.S299151,986
F17924.S304151,997
F17924.S180152,137
F17924.S070152,320
F17924.S113152,386
F17924.S328152,410
F17924.S109152,907
F17924.S350152,973
F17924.S244153,077
F17924.S062153,553
F17924.S312153,794
F17924.S260154,024
F17924.S126154,266
F17924.S114154,338
F17924.S117154,392
F17924.S200154,791
F17924.S223155,015
F17924.S149155,036
F17924.S034155,267
F17924.S027155,438
F17924.S225155,971
F17924.S296156,272
F17924.S220156,385
F17924.S221156,469
F17924.S106156,718
F17924.S264156,775
F17924.S088156,858
F17924.S015156,892
F17924.S297157,090
F17924.S049157,093
F17924.S075157,165
F17924.S208157,226
F17924.S191157,353
F17924.S007157,698
F17924.S313157,729
F17924.S242157,774
F17924.S163157,784
F17924.S265157,807
F17924.S008157,886
F17924.S197158,094
F17924.S108158,219
F17924.S284158,580
F17924.S054158,594
F17924.S241159,290
F17924.S020159,572
F17924.S218159,573
F17924.S267159,660
F17924.S187159,737
F17924.S150159,809
F17924.S132159,978
F17924.S103160,654
F17924.S348161,062
F17924.S124161,222
F17924.S097161,296
F17924.S333161,377
F17924.S167161,379
F17924.S340161,386
F17924.S307161,400
F17924.S258161,444
F17924.S178161,793
F17924.S084162,090
F17924.S058162,642
F17924.S335163,011
F17924.S226163,084
F17924.S179163,533
F17924.S164163,549
F17924.S078163,561
F17924.S278163,656
F17924.S216164,037
F17924.S243164,102
F17924.S257164,172
F17924.S194164,258
F17924.S186164,556
F17924.S110164,707
F17924.S158164,862
F17924.S283165,047
F17924.S202165,311
F17924.S136165,655
F17924.S072165,752
F17924.S098165,789
F17924.S152165,998
F17924.S310166,490
F17924.S160166,521
F17924.S172166,724
F17924.S222167,106
F17924.S205167,422
F17924.S041167,679
F17924.S129167,736
F17924.S028168,062
F17924.S050168,266
F17924.S123168,427
F17924.S203168,480
F17924.S293168,746
F17924.S147168,763
F17924.S329168,881
F17924.S141169,174
F17924.S392169,179
F17924.S171169,215
F17924.S236169,346
F17924.S181169,439
F17924.S099169,606
F17924.S003169,647
F17924.S281169,820
F17924.S004170,062
F17924.S252170,172
F17924.S337170,421
F17924.S199170,652
F17924.S146170,660
F17924.S173170,682
F17924.S087170,743
F17924.S151170,891
F17924.S292170,902
F17924.S177170,968
F17924.S105171,159
F17924.S219171,206
F17924.S139171,427
F17924.S055171,487
F17924.S092171,522
F17924.S037171,561
F17924.S040171,563
F17924.S175171,795
F17924.S094171,810
F17924.S404172,055
F17924.S154172,273
F17924.S133172,490
F17924.S029172,539
F17924.S091172,623
F17924.S012172,942
F17924.S119173,111
F17924.S138173,418
F17924.S115173,653
F17924.S344173,958
F17924.S189174,650
F17924.S116174,904
F17924.S323174,948
F17924.S013175,246
F17924.S118175,940
F17924.S128176,240
F17924.S261176,336
F17924.S043176,485
F17924.S330176,523
F17924.S343177,073
F17924.S145177,474
F17924.S266177,583
F17924.S184177,612
F17924.S024178,017
F17924.S245178,386
F17924.S074178,463
F17924.S111178,515
F17924.S153178,807
F17924.S169178,994
F17924.S156179,191
F17924.S206179,303
F17924.S077179,330
F17924.S060179,542
F17924.S016179,702
F17924.S125179,806
F17924.S319179,970
F17924.S148180,041
F17924.S035180,162
F17924.S056181,494
F17924.S005181,942
F17924.S122182,027
F17924.S347182,184
F17924.S014182,690
F17924.S309182,765
F17924.S134182,770
F17924.S270182,872
F17924.S143182,962
F17924.S230182,996
F17924.S176183,165
F17924.S030183,277
F17924.S026183,616
F17924.S059183,722
F17924.S233183,844
F17924.S326184,269
F17924.S140185,420
F17924.S352185,561
F17924.S086185,712
F17924.S066186,035
F17924.S081186,048
F17924.S196186,490
F17924.S248186,883
F17924.S045187,063
F17924.S231187,208
F17924.S251187,289
F17924.S064187,344
F17924.S227187,527
F17924.S036187,717
F17924.S237188,636
F17924.S320190,198
F17924.S168190,402
F17924.S052190,438
F17924.S271190,542
F17924.S002190,651
F17924.S235190,929
F17924.S311192,174
F17924.S322192,283
F17924.S268192,630
F17924.S277192,779
F17924.S068193,230
F17924.S357194,086
F17924.S006194,859
F17924.S044195,423
F17924.S321195,788
F17924.S282195,818
F17924.S082196,036
F17924.S379196,786
F17924.S166197,834
F17924.S107198,093
F17924.S276198,844
F17924.S161199,391
F17924.S090199,835
F17924.S093199,837
F17924.S053200,250
F17924.S185201,190
F17924.S112201,808
F17924.S022203,042
F17924.S211204,256
F17924.S240204,618
F17924.S065205,428
F17924.S057205,684
F17924.S083205,787
F17924.S165207,640
F17924.S073208,220
F17924.S131208,516
F17924.S183210,278
F17924.S159210,987
F17924.S121212,320
F17924.S048213,395
F17924.S071215,232
F17924.S038216,998
F17924.S051217,421
F17924.S080218,698
F17924.S021225,645
F17924.S063228,292
F17924.S137228,820
F17924.S262228,877
F17924.S273230,839
F17924.S182246,920
F17924.S238248,675
F17924.S067284,124
 
 
 

VII. Analysis - Read Taxonomy Assignment

Read Taxonomy Assignment - Methods

 

The species-level, open-reference 16S rRNA NGS reads taxonomy assignment pipeline

Version 20210310
 

1. Raw sequences reads in FASTA format were BLASTN-searched against a combined set of 16S rRNA reference sequences. It consists of MOMD (version 0.1), the HOMD (version 15.2 http://www.homd.org/index.php?name=seqDownload&file&type=R ), HOMD 16S rRNA RefSeq Extended Version 1.1 (EXT), GreenGene Gold (GG) (http://greengenes.lbl.gov/Download/Sequence_Data/Fasta_data_files/gold_strains_gg16S_aligned.fasta.gz) , and the NCBI 16S rRNA reference sequence set (https://ftp.ncbi.nlm.nih.gov/blast/db/16S_ribosomal_RNA.tar.gz). These sequences were screened and combined to remove short sequences (<1000nt), chimera, duplicated and sub-sequences, as well as sequences with poor taxonomy annotation (e.g., without species information). This process resulted in 1,015 from HOMD V15.22, 495 from EXT, 3,940 from GG and 18,044 from NCBI, a total of 25,120 sequences. Altogether these sequence represent a total of 15,601 oral and non-oral microbial species.

The NCBI BLASTN version 2.7.1+ (Zhang et al, 2000) was used with the default parameters. Reads with ≥ 98% sequence identity to the matched reference and ≥ 90% alignment length (i.e., ≥ 90% of the read length that was aligned to the reference and was used to calculate the sequence percent identity) were classified based on the taxonomy of the reference sequence with highest sequence identity. If a read matched with reference sequences representing more than one species with equal percent identity and alignment length, it was subject to chimera checking with USEARCH program version v8.1.1861 (Edgar 2010). Non-chimeric reads with multi-species best hits were considered valid and were assigned with a unique species notation (e.g., spp) denoting unresolvable multiple species.

2. Unassigned reads (i.e., reads with < 98% identity or < 90% alignment length) were pooled together and reads < 200 bases were removed. The remaining reads were subject to the de novo operational taxonomy unit (OTU) calling and chimera checking using the USEARCH program version v8.1.1861 (Edgar 2010). The de novo OTU calling and chimera checking was done using 98% as the sequence identity cutoff, i.e., the species-level OTU. The output of this step produced species-level de novo clustered OTUs with 98% identity. Representative reads from each of the OTUs/species were then BLASTN-searched against the same reference sequence set again to determine the closest species for these potential novel species. These potential novel species were pooled together with the reads that were signed to specie-level in the previous step, for down-stream analyses.

Reference:
Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010 Oct 1;26(19):2460-1. doi: 10.1093/bioinformatics/btq461. Epub 2010 Aug 12. PubMed PMID: 20709691.

3. Designations used in the taxonomy:

	1) Taxonomy levels are indicated by these prefixes:
	
	   k__: domain/kingdom
	   p__: phylum
	   c__: class
	   o__: order
	   f__: family
	   g__: genus  
	   s__: species
	
	   Example: 
	
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Blautia;s__faecis
		
	2) Unique level identified – known species:
	   
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__hominis
	
	   The above example shows some reads match to a single species (all levels are unique)
	
	3) Non-unique level identified – known species:

	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__multispecies_spp123_3
	   
	   The above example “s__multispecies_spp123_3” indicates certain reads equally match to 3 species of the 
	   genus Roseburia; the “spp123” is a temporally assigned species ID.
	
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__multigenus;s__multispecies_spp234_5
	   
	   The above example indicates certain reads match equally to 5 different species, which belong to multiple genera.; 
	   the “spp234” is a temporally assigned species ID.
	
	4) Unique level identified – unknown species, potential novel species:
	   
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__ hominis_nov_97%
	   
	   The above example indicates that some reads have no match to any of the reference sequences with 
	   sequence identity ≥ 98% and percent coverage (alignment length)  ≥ 98% as well. However this groups 
	   of reads (actually the representative read from a de novo  OTU) has 96% percent identity to 
	   Roseburia hominis, thus this is a potential novel species, closest to Roseburia hominis. 
	   (But they are not the same species).
	
	5) Multiple level identified – unknown species, potential novel species:
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__ multispecies_sppn123_3_nov_96%
	
	   The above example indicates that some reads have no match to any of the reference sequences 
	   with sequence identity ≥ 98% and percent coverage (alignment length)  ≥ 98% as well. 
	   However this groups of reads (actually the representative read from a de novo  OTU) 
	   has 96% percent identity equally to 3 species in Roseburia. Thus this is no single 
	   closest species, instead this group of reads match equally to multiple species at 96%. 
	   Since they have passed chimera check so they represent a novel species. “sppn123” is a 
	   temporary ID for this potential novel species.

 
4. The taxonomy assignment algorithm is illustrated in this flow char below:
 
 
 
 

Read Taxonomy Assignment - Result Summary *

CodeCategoryMPC=0% (>=1 read)MPC=0.01%(>=6328 reads)
ATotal reads63,590,44063,590,440
BTotal assigned reads63,282,89963,282,899
CAssigned reads in species with read count < MPC0487,169
DAssigned reads in samples with read count < 50000
ETotal samples408408
FSamples with reads >= 500408408
GSamples with reads < 50000
HTotal assigned reads used for analysis (B-C-D)63,282,89962,795,730
IReads assigned to single species58,922,59158,622,752
JReads assigned to multiple species2,685,7812,654,474
KReads assigned to novel species1,674,5271,518,504
LTotal number of species1,794371
MNumber of single species578308
NNumber of multi-species6316
ONumber of novel species1,15347
PTotal unassigned reads307,541307,541
QChimeric reads15,20515,205
RReads without BLASTN hits5,0405,040
SOthers: short, low quality, singletons, etc.287,296287,296
A=B+P=C+D+H+Q+R+S
E=F+G
B=C+D+H
H=I+J+K
L=M+N+O
P=Q+R+S
* MPC = Minimal percent (of all assigned reads) read count per species, species with read count < MPC were removed.
* Samples with reads < 500 were removed from downstream analyses.
* The assignment result from MPC=0.1% was used in the downstream analyses.
 
 
 

Read Taxonomy Assignment - ASV Species-Level Read Counts Table

This table shows the read counts for each sample (columns) and each species identified based on the ASV sequences. The downstream analyses were based on this table.
SPIDTaxonomyF17924.S001F17924.S002F17924.S003F17924.S004F17924.S005F17924.S006F17924.S007F17924.S008F17924.S009F17924.S010F17924.S011F17924.S012F17924.S013F17924.S014F17924.S015F17924.S016F17924.S017F17924.S018F17924.S019F17924.S020F17924.S021F17924.S022F17924.S023F17924.S024F17924.S025F17924.S026F17924.S027F17924.S028F17924.S029F17924.S030F17924.S031F17924.S032F17924.S033F17924.S034F17924.S035F17924.S036F17924.S037F17924.S038F17924.S039F17924.S040F17924.S041F17924.S042F17924.S043F17924.S044F17924.S045F17924.S046F17924.S047F17924.S048F17924.S049F17924.S050F17924.S051F17924.S052F17924.S053F17924.S054F17924.S055F17924.S056F17924.S057F17924.S058F17924.S059F17924.S060F17924.S061F17924.S062F17924.S063F17924.S064F17924.S065F17924.S066F17924.S067F17924.S068F17924.S069F17924.S070F17924.S071F17924.S072F17924.S073F17924.S074F17924.S075F17924.S076F17924.S077F17924.S078F17924.S079F17924.S080F17924.S081F17924.S082F17924.S083F17924.S084F17924.S085F17924.S086F17924.S087F17924.S088F17924.S089F17924.S090F17924.S091F17924.S092F17924.S093F17924.S094F17924.S095F17924.S096F17924.S097F17924.S098F17924.S099F17924.S100F17924.S101F17924.S102F17924.S103F17924.S104F17924.S105F17924.S106F17924.S107F17924.S108F17924.S109F17924.S110F17924.S111F17924.S112F17924.S113F17924.S114F17924.S115F17924.S116F17924.S117F17924.S118F17924.S119F17924.S120F17924.S121F17924.S122F17924.S123F17924.S124F17924.S125F17924.S126F17924.S127F17924.S128F17924.S129F17924.S130F17924.S131F17924.S132F17924.S133F17924.S134F17924.S135F17924.S136F17924.S137F17924.S138F17924.S139F17924.S140F17924.S141F17924.S142F17924.S143F17924.S144F17924.S145F17924.S146F17924.S147F17924.S148F17924.S149F17924.S150F17924.S151F17924.S152F17924.S153F17924.S154F17924.S155F17924.S156F17924.S157F17924.S158F17924.S159F17924.S160F17924.S161F17924.S162F17924.S163F17924.S164F17924.S165F17924.S166F17924.S167F17924.S168F17924.S169F17924.S170F17924.S171F17924.S172F17924.S173F17924.S174F17924.S175F17924.S176F17924.S177F17924.S178F17924.S179F17924.S180F17924.S181F17924.S182F17924.S183F17924.S184F17924.S185F17924.S186F17924.S187F17924.S188F17924.S189F17924.S190F17924.S191F17924.S192F17924.S193F17924.S194F17924.S195F17924.S196F17924.S197F17924.S198F17924.S199F17924.S200F17924.S201F17924.S202F17924.S203F17924.S204F17924.S205F17924.S206F17924.S207F17924.S208F17924.S209F17924.S210F17924.S211F17924.S212F17924.S213F17924.S214F17924.S215F17924.S216F17924.S217F17924.S218F17924.S219F17924.S220F17924.S221F17924.S222F17924.S223F17924.S224F17924.S225F17924.S226F17924.S227F17924.S228F17924.S229F17924.S230F17924.S231F17924.S232F17924.S233F17924.S234F17924.S235F17924.S236F17924.S237F17924.S238F17924.S239F17924.S240F17924.S241F17924.S242F17924.S243F17924.S244F17924.S245F17924.S246F17924.S247F17924.S248F17924.S249F17924.S250F17924.S251F17924.S252F17924.S253F17924.S254F17924.S255F17924.S256F17924.S257F17924.S258F17924.S259F17924.S260F17924.S261F17924.S262F17924.S263F17924.S264F17924.S265F17924.S266F17924.S267F17924.S268F17924.S269F17924.S270F17924.S271F17924.S272F17924.S273F17924.S274F17924.S275F17924.S276F17924.S277F17924.S278F17924.S279F17924.S280F17924.S281F17924.S282F17924.S283F17924.S284F17924.S285F17924.S286F17924.S287F17924.S288F17924.S289F17924.S290F17924.S291F17924.S292F17924.S293F17924.S294F17924.S295F17924.S296F17924.S297F17924.S298F17924.S299F17924.S300F17924.S301F17924.S302F17924.S303F17924.S304F17924.S305F17924.S306F17924.S307F17924.S308F17924.S309F17924.S310F17924.S311F17924.S312F17924.S313F17924.S314F17924.S315F17924.S316F17924.S317F17924.S318F17924.S319F17924.S320F17924.S321F17924.S322F17924.S323F17924.S324F17924.S325F17924.S326F17924.S327F17924.S328F17924.S329F17924.S330F17924.S331F17924.S332F17924.S333F17924.S334F17924.S335F17924.S336F17924.S337F17924.S338F17924.S339F17924.S340F17924.S341F17924.S342F17924.S343F17924.S344F17924.S345F17924.S346F17924.S347F17924.S348F17924.S349F17924.S350F17924.S351F17924.S352F17924.S353F17924.S354F17924.S355F17924.S356F17924.S357F17924.S358F17924.S359F17924.S360F17924.S361F17924.S362F17924.S363F17924.S364F17924.S365F17924.S366F17924.S367F17924.S368F17924.S369F17924.S370F17924.S371F17924.S372F17924.S373F17924.S374F17924.S375F17924.S376F17924.S377F17924.S378F17924.S379F17924.S380F17924.S381F17924.S382F17924.S383F17924.S384F17924.S385F17924.S386F17924.S387F17924.S388F17924.S389F17924.S390F17924.S391F17924.S392F17924.S393F17924.S394F17924.S395F17924.S396F17924.S397F17924.S398F17924.S399F17924.S400F17924.S401F17924.S402F17924.S403F17924.S404F17924.S405F17924.S406F17924.S407F17924.S408
SP1Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sanguinis4735171304184708435742778719136586118538037590448597770193160551193811873561928211432371133222204778822261381379140388953764259448350383987764687355504503231620665222119326121348631096323212810632639789787466858966412321410254602054480214147114813703124027292100842672175161906798642815013100270020921016466235251277820480218721441665395919871285143664242513426999487680206654152452043973452361506281371729694437128413188174867193142484423555176410386228656155584951255105898603622625581748167229108144590234610210154451256203687126511928138931215964682744421789486664032723738809219451123101354451710418237927819938328913041427257736111547169791023447477455003531040967013203119812548653458247816739114341349422886187549117533672109918026269955408024576596169509622807091765245222323814671413186876463277236185210510436147122285651619131043586123720532154446183448236197481559355483449911813994154177882616863599049402341626071541111203641002548651421101991105612250114434021314895529600652015782723362252488511419291151250146359965569143178313488134010966744147132604464242454718736221630125337527156192445803523165734839452101188311457258285104811515316645383830465851029491855430269225203957116381332855834277637073284469646203321725695858601266691119718880932628215727012776224191786168100179966515216775533446441438522738692511273100527197181534145414811421310102703810495
SP10Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;sp. HMT78000000000000075000003000050600000081536610200000003910006100000000000011000000101100010080000000001301700000001320001300000005000000002500410000601700000070017692400050000000180000000000005000000040004000000000002145400000042000500008001500000040060050000120513080000340015554090700003100040000000190000310000001650001401199000007000241510500000008760080000290060001210416830278002620000440526010570004000518185074807770033255000390000800370000255000000136000014682290600023000191354569060000550210029
SP101Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;ochracea000000000000000054231606380417386020000005060296002783100130000132176237700543000000000000001540050314013660269742035000003760311004310200010000494771916007600000000300000068006531690026408666026600000310000072451006000018526033300163016000000000000201006832103840299172023600000234091100116520000000071331999003980000000000000000000000000000000000000000000000036003000000000000000005700000000000000000000000002006000000000000000000002125011000000000000000000000000073900100000000000000000016900025000000000080000600000000860000
SP102Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT45848100449068770497222332681428181104892700572813124771046222297158425331170253000018322700845839274724648762529920297418944705028212610116542697760095657701889541803973896151592632099103025432921700308625221722205273602290503989275218741371543171806169611532759022191220202415243620013097070141332713708654588022379439631816618761369773404139159566191194087003201977066551476147674801340023786572356065112202890130000459470377406111141409613092162185382743308233814561157142534791108246072001759720011145014883547101101331702482620198581088631040014220401782756034349171414251715510704210000001117340728391805101900177002966000173304302525166401517401424240120142360500076200121611026090086110213065247220018817707163628296145040318501114541991484178851976983520046011110163279791281722307303711834680470902428508900109137069870158578531144113702907742981298105317497251013327267026171683920142701113891500523140101462
SP104Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;haemolyticus000100019230003000368310000291500010400000057276101421900480320195812140564350000123014015071008683078001144140000103002740034240023310507506804500552700018004417000000047800360161500016900550076470673700210120540455024910000560123241200000330000006960503700700436114052000252028052003814000141935920050260001294056036408650004529084031015159761532961409710832038103120600073705647351223030401070110013190118096760001400231300011125007133708290871580008648725031452702590091053400579004556422343778141413154010530412770204926521071381106810901123285955395645929301933097000919510214165793472670933759504960136428392665181328720490066901030300500273381797670142935428970133408
SP105Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT94900000000060900017700685001328070001600800017000120702490072000001620000050008022300001210001030301850016002400000003090588830033000001100000000010043004260072003330000000018040000040001498015000008000000000001970000800039060120000019000000000001907600560000000000000000000000300000000800200000000000800000000700000000000000000000000000140000000000000000000000000000000000000025004400090000140000000000000066002200000700000080000000000000001000000000000000000000000600009
SP107Bacteria;Actinobacteria;Actinobacteria;Propionibacteriales;Propionibacteriaceae;Arachnia;propionica25979303646350110087784101744759465684828991438179901703419871982332344186811502217307614321385473023778923362156543353125115913199224436322245864852990809801200682125723873331940664237613570301462219215309234857135563180545020914199107836124577725842166104044340662713495195493451982536711881701468389428052590202921362073200138262060818515903167581971155668537313594616182540527592561196816069812152345551435173172359240513310121082661410228371174288210151021669137528612654944196105913114347312391120162728451722408711017319635075262222320331840158910314689132160445518881473384325651013267212706091923537443661803210616971034561254246118783664840156943913982161992329868752507046051001204800001050500013400000014140309512125050069100011000200030080500600000402010011500000380410509121190140713001411826149721442096043961495360742105138142312204313703503102394228334152961168632169715817227518889010475533132121449249132228080088764744523702408017121940392882417015434149112752317029
SP108Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;gingivalis30802482214179577537317362668495642702953234529317832163196904543346424711047784615417722554150184027169217438263712779493110829147046594718595587121735910167062165681002661027516707272473021381528195039715871324156138075755611039571879333124811151861121192415028243962106920831022136157992162967803622788523753832302776726972423584983674410315102207858452020863222113476124310303672240838559025331543659246582331558056226836565344736399595364780162018371566343869219925130639064722248221294754634113806923756112088271479202198114275530416788210933580207510861259954216197153832327313018432301536135638447178848021610414158548121213885302372961571300496590002404327014102035240196200172967951811151960156029571240001511797987312431105816021901552850007098114128815031632072003186406301045106002201847101201920019072312901943081021325531210300100170860646223294415047762714345625712571841013936814393049291019820294001390567876271966620493145289270050244107102391703319618024799279661561235303611401510518584214815113155025078142911613120103113180281040192319081461458800
SP109Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;sp. HMT2378600000000000000002400000000000306000070030073700000000004820000000000120000016000838000000581572520007100185022006000000009100550000000000000971700000002900022912021217004156305261300235000000000021100566000000026000049439000111400800941735103911580001090663601861170350000000000000000000000000000000000047000000200000000000000000005000000070000000000000000010400000000800000000000700103017000004800003150000008002424917100315800105017160600000000028002600000001900002160000005003676160000000162015600000000000
SP11Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT215192644178413250301620221119515749198354552926651220010884001778150357603911348150100320126311319010790121099340103071500106187597507121317796580015475020176447720130427102965615146511690151137012516386531530017524116911012043715208219590646411204119523242011520512422040312934191243462591421325640106200162533901701550511724102410013807384460172201101402101521049405015144970207448118729014354126470214408047127709746382017501711127635701636206291102003348818600042900219210290780306662192947221891439179192921715652135235976927739402314810141482297028417360133454923922301310438510313823627628325351517054142751554323440031137658723482221006483680235833555063549085797998204033575342317423101173338018637018232196193651901775218274557412364157097700381367598902495131217214833183957556245316290567793214486521893292845105300806471024561401004113860264375474614990511230909107297257584421804622679927913513512441426743183690854910388033417155433471911581603251811021658018349506953634523893140814816317975150600225
SP110Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;veroralis9002100109435000005200000900039902640300000009000201290000063100000000001500011083001300400010718020610394000035576000103000000540050200000140182600000160005600110001781070337201594000021662003103000143458100000360008315004002496100087005504162005700067472050959014500000014903740082885000002147003700000000000100050703000060048001100002003110002300000080000000000000000074600000004009710000006000000150000003004000705301600045023460529055050280050001550000126246929120067064000004000111100190261238000100019235000800050029401500002473222560018700000063000
SP111Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT317145100735007913700643000134417819560889600761389400435207004597952000243144401518210110306600033630000573322027920016562616229146170851466010551798239659201212780232180248901666645888202115317423234709002632278478839731866312134228186605660258008548321606001151429806864706615136201430436721521104768688148934851904506756823320130188119762337453006647215229701331191532018103523014500389952671344001821208297113647138412644403162725136810302071760313364715011190691012261711140822020327445663937128441001559621070454360553422195516190105507300174496600000000480000001270000000427001201200000800070000120050000700500500000703800000465106008141103000160210280030000092000102017921021090626182931438033000761438083018240187711219008331130001800271638000872365139156600535173213753111882804076210273427809003654700606890410131001047
SP112Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT13415200140018050000040000000290000011006500000000001700000030883800019414011900000620023000100000023038655600000033015100000018013643810020511004000151002200380003450002502540916143800000384107236000200980522129500510473461480026130370030300548800052401450171431351000200006510182122740000001060774520000000000000000000000000000000000000000000000000000000000000000000000000003059000500000000000000000000000001104001511000000000700002033002000000110017000000000016000000000000000110010000200288000000000230000000000000
SP114Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;saburreum11250483544106508445516060111299033160372033060883172010973441100891901851588286608069201603578248143627017044768170199160177624450816653056957543436096717404670142621550118573601068641425293423782001036622546209971492001868609151071136173234615234669299223144517765313320694225504405127513492349630800116948989194319418010598104092199267802511914737517343692260051201425327855559500140114065370509110479226780116282110992183032467448671610290135121355154762235541547951187244811444561041038022523157873234010883045345030576197842199502381012167258715591165001450011000031079002100001200220019004700020001508000001500010570000183280310660416060000000013101800930469110010003100001700000024191236034224655200370010701861404100120164062001200425000210041016162521003090002602003350261360180042910498025901601150490026003528022100343000145939006466037815
SP115Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;sputorum0000002500000190001100150500000000029001108300103700000070136400000000010004050005000000000000002500604000006940000036700000000002400000000025000000000001700003600021000001000172600000000000047000000000000000000000502800000173700000220013000220105703753010600012006627370000645506720018003742931871790723381292208098540691680000603612015400780004100349215500076102800160016610519092020919007870016805226211400029011998121121017105000143001189281074000243360172000270019849491413270682112336718905008556060376415000170941303290046100028700109611443800303501470010700360140427854056066277567317066170110573
SP116Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT423378415834152061511737916268002985819549661810862735159072547585814116818247798184970114028872570428575961826020779327634516188421140579912982108774187313390217420631119259001931990378113141703121979747041128434846555862568237633203121326141484744174697493066738341253845240373384424047405310411161204271524728309591718654817089071971223178497716194011761742390017931370639645084667967603773911138109713885519624277014418652884636582280970143741207120905507585540929391753012947727911072431326839395931310077440319851700144161019495749450212141470407731501185811083963593414236125375062643631007468124932008695913295828561344361916062346131305621614569582100730958319709028914721686736483011929111071016879851414272166229379803234165790388264854012592492422910302791981111343732418053254671252012732247444326111451230237543739342340635158207402356294052606130579377321517042364213002944314143228423947023716165642270140243108401406756978211181334025283026136743471571491162158471892312336625928641572678229493017431962283222250412727812500758121738174121412313530489618641202125072118711971335100340022264621521712819818833691947877622817659987562027136297893933353861373178414924640928173753555154410572011303513352071425226443482223038524039522373003791405469494232221341551082136442023772042282457246137088649281445261152552451700228912247134401393847048491184
SP117Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;oris726191517112339032493150916423919113233922101732696377934431724111593173656384224448721203023999576293773236587900297571723652801457302679676117535045382835423205077513277510041944113432681587511716827562777329794264413063971431048782310760221144597381226919329233189338208387523405405700018221199143315891784944536164702343310610165425663830981178133521053267291615962196601336101128813562121666513412319144379370202216276410721282414215943232513619501113560184978132302744915127312639166295325221046272515902702211617636593821220240921825216301062406192073229515281127121925793273995865001288418719956557228500303306433164025622311404046195026213450824001142706619503229030120205131100002729224003214151181027060007471050001903863037911164852132440831941000130600850317000445825683207100724000134514173517254532131616214622137180588916766560190126112002710414013495112300278045740140640181516017022031933940951013010512848252114110196337371393721152580162103061989543531423111811712440134217232446562434932536531970488103
SP118Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;gingivalis0031541000000038919992182343271194200227461400100000024300181326229342038002952280190012842001919638014000139023111350071222000420215000001110038007151413318065045410031018662153606468008500007119100120676902900644151203935946260000000090003907831510680786220400001023008350230000073219760968050401416179002140076004900510618303973620000004086929212505240169030347128168815746112628114281163358337106055258103419710463501025031580180376262675145369469205002231491844598313131413894836136640403502383793072189021298619939769157597880892869564007431700753250935002171983429454491294060325432492241015732565924661894312817424027537214927391033104334615244742611325512188093356483902620129315003749132349169824711503130328521847549121053211017071002082028526488125103144195511243411348285022774363127301110670692500031605044231717230907819739277105873202343421778378
SP119Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT898000930096003601080003300067000009455010300000196704230792070076525203904811150028700018500142001431016040000000420000020240050000060804024003206239083016616400120001300154001990720002300014000004044100000008199020351267010102204000104176200120000200034001967021200000001050000051200000000316011230001699033055686000000000000500000180000000000350000000360123100040000361300700022000007000000000000000000000000904000000000000000001132000001300000279000420000013320770000012901771900004801001135100175000231000004700000800000000053000001100790012000060008015000
SP12Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;downii02419920146503110064229031411330012062334330236922091500000120165029559944101620724160027901903362303350477202238004441866226225395213386904866018084030012819003167016040164040803790131202350042006689771915148401691065001354730636135400259138109556122801248000370355070341216716609101452853407093103999188001125301760094300988136051361526119111754701001261721033900010240253049100103003802145779141289003167440184223110158601013752840945857145031851650473731308341313669881681140910159114558955599191202611895806520135962439370296187815365256904562193141232084364630674920407758782636349966641314890814121174611908402631281124025847740761046137212601544122011169112428427239341710778360436770776585835332306041897360259017025040341495118201447991269515498517176224716133111951702841625249163918816745083078252314614345657472852214516871718793136513678022001097967836543219250002422729402198146264522422139760235952426921911412710621050237601251181760100210673645788193102117146217352135027508674628361381540106785301735013321454
SP120Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;gracilis7912453957569402134491275406359128334241280291052215195312506185354325950144119196965947763343636471134033671556437123557576185137652134419699811738272075546781419917123387407285551505203183447855770348383655980220136055481955847180147482034684381192696813343794321161512322162242887023047112124321452359119674648105118151169809564124925698669013363081686705928402244837378108363270010848997442842171136186842310674735381418525137209094124563035905461467154874349136318933971011159534960890023958110513487784188627085795149610403346309457048910971781960154121464372205144920540177664365195178118556868863348910002299720030500030000000000000000031000000000000000000080001000800003090000000460000000200010000700090030050000000154122182061041250230289000655097490133229900000902012136318061110130220412344225008022185002102214281400027600515171123601081210012417212140001907600
SP122Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT4120024000000000000000020387100276000000913012620000000173000408000020540007600000000000002050056162005000000077201095000000000009600004048004000300000000000161007851520433000000558000002020001150006300000211457001700840000073000022900288332110830000004540349700005600112000880000160130070000000000000000000000000000000000000000000000000000000000000000000006000000000000000000300000000000021000050000000000022000110000109002003500150007000001200130000000000000200140140000000000000002000130000000000
SP125Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;australis1543367288088142712179303067111135691012103109622158020600280872208187209740025869830210123446062063100376304039120282899676400278766153042025100125010148313511032216501540932768127804201701019881282111561186356502001946926558067260373414450181180002148606734209430014412100300000030190300111201818013134612174881140267086172210103207200132126621395761232524110023101209510015034108144353741204920269087348516562236588226412618234890154013095477033378343841640612503846081196081417099604307022109751271956746207551402310351213362218543646854674404194151614973331617311332146766316249146113759026330119294759923097880513201272198412276658214124360115863550138251581181298446483790319171232485656690547399961228574643953412011698013287146865913151621225246712267211046627844505162408548552175114382340421011392262540651132545704171270361558291021361041175063296239821115092542131232435938299291984096462756135920125518653021254285416741007270247450871401451223215362880501026115045313416611357390217380539210998023241309146630636454245840110893381731585187514215018890820405730
SP126Bacteria;Proteobacteria;Betaproteobacteria;Burkholderiales;Burkholderiaceae;Lautropia;mirabilis817833402277152387681173817312382069186855331090547628015951033801939025531512597625014588559014924033532532886235377346147130942232009131136582275925424041116129579513483546138493636982705338101716611837414332443681991072207246812994782185499776504470125665636632710104055422467061956151182185231782155549851717088739347952917327214194101068283103129816226794615060023957251914541961297308690746606212245340315874085731602013406581377236121274943337031021912844442986526279936759821365735891266224337504248513328477823421787574760533661612355109110993441401355856242086492137212168513856703434231404145216035113082150568321241633491175935928131224525647566191814612061341671341002369785134105802211332240151731002049151706328445174201140302800635121016211466274736111220957311596541222190915301481203137318098004215345320029700276630491113154202854316194601466381488423201313158184517556429629586465322252297132201208292221546431363995960437149214556410016119341804623572514328242713794150753791427131314054215462703371614323172481291140152146163046844193153261224429200107462611617101181907235551111742481952010752425919669214
SP127Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_subsp._vincentii830003900000000052800000708780014800001903700130028900758000000256000374100574240000018882185001500175088440010216136083706315709000138004618800000480600018890020235578000021701561320000032201370014207120136200253114004701497800842000000200601420197600674183731340002936753273251090027001530012270086920426203950323222260054002962498434970000013317301330100081036000002000410000700000050161324000100000048290000019000000780170070017000000010018000015958124140021000801570000053400047001096761866000030423201280000093028014011825502303636001277700411052727830000013800027700135679582003001462060000011901450102479114449183100272100106005922113000075516040
SP128Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Dialister;invisus7393618436260103213702100152187313500712099245030540351902270406014161096124882758642581943006422309134824211115816293104502369254555461360818179202161286296195170710602271632619540164138119618815571651036143097690499301579698547617619366352086229143929465924134711079408250113210163166301726695050224404002311221616101415517382754588592890969421546928118229311086316011191734033779015111653147311545019591413208447302195393155349113919292510902497104533411663462952294128318291558297542932124110711202775548884434731272291663925592414871260004006004005140460800500080544013111583205446041340000300606048187045913822782113113006040070363031290010002080211370100090801091722184367378111958137194345127337636962406995465332415933215427161947184371672232850942759022366730540312821114508973764106094107019105284016372273527148838733857915820010025142024
SP129Bacteria;Firmicutes;Clostridia;Clostridiales;Peptoniphilaceae;Parvimonas;sp. HMT110650060067404425740877109704820000161641033001690214091180150015706012104406741120000002925200047300267067044141917087000061347401431027640013449919880057490078000153520000021562000011541259015940698407903734079815289800521675013590563173480140157522009591839087000090672830000371160710170007681720116034022403234020313300036538710820162183158030413470100185000000001892530000017991840000000000040009181800000630014003300070002100000000000000006000009050047000070000001050051500000000000200000600000905016080168530811121730032130472549101516160039000205008022000000165000801101580103003113011300004800240060048070004000120040240000036960
SP13Bacteria;Firmicutes;Clostridia;Eubacteriales;Lachnospiraceae;Lachnospiraceae_[G-2];bacterium HMT096149002517000000600000000610000000011038000000000000110000001200075634000000000000000160000000057022000000000000000000041000120000006650000000019000000002203900000000139000130000002790001130000004400000000000150000019020000000001070000000000243500193500019370016500000450009090012049004073106500000649000802190066200008350195600371144304871120027478350005610009276006069780268430675080036300028359200000005170308500011130016593001850340002300037160034068005374306280350050000053813230035100002460572004393702037250018253890002860008031008002700531704010000526000234239200000002830
SP130Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;trevisanii10100000128708000025000006201370471000000000000133300004500048300027200000303804000029000001867016907800002100000004550000351010000252000600000329208100000000007501501880000000000410400000311130001742000530000087304200000000003840196501900009500000008000090520105000127100000000000000005000000000000000000000000000000000000000000013000000000004000000000000000000000000400000000000000000000500000310000000032000000011000041400007000000000212018000015000002803200000020000000020009400009000
SP132Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT47300004046510413001164490000026000000430560004171772241070255152620000797022336037766000000842503673225350010080000751220646601202170000641267250416131816160012016870860456018012400000010670258002437847000075000070050012110001938601177681100002052004400261182000000894140129706151087010900000140804002040000995000061228301569128208800750171502991154099380000606235407870352315022001070004404933480285100010130411809179142112612170400134823217012390002200124115001138457039000018000112263345200110800001250824241649551756300209270616484018000008053350263580489834810443001267280092761403701775600177834294743153919671133290203703349785469082950000005936505753452399101460000231016102202614518092900149106713276933215731857310943016030244216000021
SP133Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;chosunense0034313046108650516552278755327382062132500001168515300024600032003075042195021296020053715732222125533487441920944251201536039496663545162401541082783880575224031700044518168911902380077900264030356312481861172652771542820110143285213550001004913137702460346841421610481193648365200270612225440011400055006470288092504598148823638102120234411020621633053722001767019478727182328605112820213015319272529000178187511740514020170023964036975826813030402732159060137374194237620257262302603413597274521183389379154717810703251371222345851411419221012824002681700352158210961270290719248224512641789791103312242224009874661267635217548115024946150216735121812979302211425514679716617539380139710024013540322922773863981108666133250474167684145418410484670707533502301270838111998116221271755166353111159093267885605143318647160349982936440851115002277233004054833311509201095538282815657269358410208754641227165366798199262421302736306546346762892416543802500254120591264198661626264259975602407409214910054912274021672320067722972679520306820736211233226532533770824911843602112259662684
SP134Bacteria;Firmicutes;Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;adiacens540291430829555020131440211597815302086263508308901594430715389899118025878829851082115841482294941768795289833272849913262391187141865518120227992281540347117911414931857102113483529802201885237185315037796252132552331361743319616861748915955433127213100868158893956355063812514514626163510383172110538227684810302115254221933401654594314810892999981308770194172410957538654513735402115820439290484211078991113209315747271639826232818464564979344036276439453145199234838547850947652934391353852335432612646113535313135861170270172019011943712162348194813657611189595101175221716873491136981317360239945731188289236244715738713753534271839940826199046588547456155331333844557536452059562518242916078238927294299870946324173916169506043765864248733792645724655801910873774988323432600621773339204453857686228325587825811698854821001416563106461171569390521426141323206294217534246361412005659011992715178377092366215005691126721007523524143648665086924481492416701880273337512141339351191921152842690076516359296310779748448891620151368409908109163430588196828363391104144353848274019801738718354334173520108434192657254999242805932334944443069594018122041167836653085364341602478109932892186100229423710186429972580256538172029395323592330267955656396135057822585303340532170245992582834312224544629012833186151072555240752718953308345176813703003800312416811907492920712242129639913552434897110539972177149120423197229225111202485239345044974682560280258122378396721082488
SP135Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;salivarius1076783813010147027242324200119451538410202312232817200611871521613787165332750045222764932896115305225352676192521200272558101248033495791468348660763155504532080156121721549147131691033791673380037706364313927414289041008272559421100214833951478301816161651001207841431249062790073613882245431011613713101192017271833733003984289900157017883432269150143267700406417628603221081485717547467194134310019002823437203102338516356181923421842595245820678188262078923111190981034890358465762893343426873412861983347675385243988002795145676652319342222110141907826896871151381531154251342635789915636125198346199671597669639413330324551773118967385763089394801120931138128379390431774514984279379097932683846408382394594829757657632963680143071724712436684519310378415471832119794493922019494067538082271723497588115960114394878661456230740100184505179127120048283554884427462313111055564383782532875935717499276651006718935237163219314286359671522531467124934036807020011841931178114126508856845234854106693231081249203796120716592103234012935672961699716552343216374256137096160662026322314114281839015710150811099123542194734040989153060989549425986255650712392910967796558921648322641111115775705837106157622059419453733861040723271122319971994169455486728267732659759103729138197773400039198951437330097
SP136Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;hongkongensis6391040815463922945756206229295825901266373004090490711507203124310004881240223172762672696545410212168545411652790602728352934178351326333203852796001518428315313731221118663842364497532033572722967303904200087151279155836901013191575303165412225260742223208050862792564008586144872681211086318401514143102029892843636130048103528129571672801176320723117310046113535315624251329321503741937110401631226108151429101548417616001030102397018512418430101193200115217786393376816314628117477405476312401703347000211110436571169585248251053714329476205368734804480034218323225042886301158260013112931272629017380340100150075014160110001913241100038000000002232880002100352123612232371314380250240000071217900923592002610012007001000219001600183001779354884955092322616390052117276281741471125635526569105036000001224061745432007914000242612823394433416405312648517330000802945160581049253212214115250023202240552701617250157016
SP137Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Filifactor;alocis570000000000001870000000000000000000019004001630000001140003330000000000001680020002503800000010511000200029300900000076400014600970000000002500109009000000000123400001091104001499003420000005210003140012805490000000390025500197085000000404000000005820021100000056900000010060000000000000000002000000000298007001200000038300000003000000000005004000000003000002600400000000052900016001691330700000001900560048020000005011000293510094003211500000422000410096153800000000004600720130000003913000592002130065700000700000
SP138Bacteria;Firmicutes;Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;elegans00003000000010249000004000080290700000561365062901326010102232100197000000000000432250101700500013527000006001301780490302461601258127000590120000000000051000008700004073000000029062871303002100029180119200000120000008900000000057300000000515081949002401301312380017200150960330000209338937000020000122843590230002225249170154166110393500010140107081100087004800000381137515200990093601425040006803160857819822032246030902022400410380371111900002889567803901345003455020277382065089309083675107819107211824322657991026371783230595560061950102231650615636843317280057140059593154050302640388048615039442333411761702329513491430073
SP139Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;constellatus774003000149000005991008191000009600000255077000022000647021000000000138770013006901125300280477580000565863000089000430049000018610314000000000341803052945011245010437801310483140400000100000005400881213007223100058852230000000007570002631014016251932206231386026781859790000998813402002899044128380006380002512894678400000000472000903000001505016000000000606182001800140000000300000000026003802300100801107000000000000123008200090000040170000000003411301510598009331392210126920000061101400521701977400106180077951451500000000324970292042027039342310121138900000053000053106423670021200050484521000000000
SP14Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT9120000000093000032000000136000000000040000286615700188096030000000000000000000029000000300520000000700005323600034029260001500000000000810000290091400052004000000029800005314140030604670500037000000000000000020040001500113000000350000231467001280484140000210000000000000000000200000000000000000001030023003000000000000000000000000000000000000005000091000600000020000000000050000400200000004000000060900804400670249000000000000000000000000000090000003003000002424005302460000000
SP140Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis_subsp._tigurinus_clade_071003669067100104013197990509064226402577146027040970006026914000581515626764537014908000001048600220321001077015080032779103106740000311214240148476507351240060081576002019103053805315450349328500001220800493283008382033580128220144928105000308642020688221043742660000015115100512838612114427900162010100002715800160377003376013170088050511466803100016692286077313461015415941101000083021008404806451206201833414000045160032482008309800400191030707437000032205080038900704307320115660000107900470014401000012072300000969350630910235130340017612000027079010939000017200249031184041144067001224132018022178203089384413901800001177100308877137298057214700002835003069096830553001350121010160007251744063284772245802700203300005236713150076020900001882002691
SP141Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;sp. HMT1804056411818121612402071070020714692818047220196601666239122657310102350962916185618701094144048303210184047917366323051462938522811181560580862136948501181106687229932206419611739654208477316160426501349502113234817319556003235048156285019936231325157992060239040741987516728036161178018638522140084441461506054544811038326978364799888685221008279477205112843316100473981016043018327040105748664736794291318816402298131706861596643962591434107316284560329714913628671472414667994312439131471956169228306768501416841911972107986060624105261292613204587347205803914087627635180512129816049211921597195007529134662700883824353686459429296352291156366627070102571097619018245881591372351240806718691012021882394137199727353237620352818091663117190025406542276604812368533132527261430400355865659910737584023174371685834105298714331063132305345200329305004325436300316145333903810617046381137492861519033279053572181165114275512934497714233402690332689384172236835373786518386325208261223070611453819502553877201319658151624090021945428261215218808107566301034105725123018557291239681400588533452506177
SP142Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;flava357100540001076124100001499091700001449003668001500000121003672346205770100000457013051123300006260000223587400001103136000008351904102006420000056001116189804130600000171517108500005155934000469342000037008400003632006150057100000000025430228641200000437134153600000154800015914270000456800000353004770024900000230001334538059800000183101390000343620002731460000310590000137002700900000000013870228000001300154000008000514696000032580000030001700400000018000354080630000088002700001889530005683460000127059800001716002020038000003000649361161794000004864362520000145100020125970000471550000020800132009400000580001893861056000000861061370000
SP143Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;pasteri1150907960310387522216641372574195056099875069315105035224907562029970002172600131642025237051697503041678082698203219783545021877160606936812327916802770093713214616115195121800562189415039154177429038561113566690933269181014229645316245112439550647839444654035422885743660123890183731171221157718272971930312446777382762582145401323366106601633321928160431200574106113155226293161225264469124776041118370002297022782600137077462060427053260425068127836700142312208505670364220901421761691164435383703863093483095651286010354451610122361143127315080912531532316121380288688936556803092421823728691803779507890286805265191337441206158819829773112287454116627969622417223581142112163396420388809051051614223110781411042449749278014781508901110116121111805471122291948662853970309127286123933615073884561410691265922817174896429528910981366614101523110204012451978120378981128622599165736448066852276411227501569605038247757600514450297417720203210152314934261587788576112678221974244743961291983482241307577493790128558120020922151207217251444766192022207940653212375190467605805910191068355118569001307469912088160804436042334717338316353363422202518860585054875112035558
SP144Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Mitsuokella;sp. HMT5214990000000000200000000000000000032000004900006700000000062700000000001600000000000000004700000000000050500000000015700000000007685000000000000153000820300000300007000000000929000000000082000000000000000002220180000000000290000000005000000000022000000000000000002070000000000280000000001910000000000400000000000000000974000000000032400000000033000000000017000000000000000016255400000000002600000000001510000000000000000000000000004351800000000001725000000000
SP145Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sputigena15878889611583692241958556264314529452188156954839116163122297188619601334160694833921797048258463555946230475591134713653193923153421236548121123694836638227646574636447915157280017721973576292101263270338488741646771129150511097736639143082898123012412048360692499132312341449120212311421111115718561297153713331034382115538114894127131862154828319355421131884065834578581300275052231342233447537583945675921373167960323030235719516642325167817217130853718843265373215410571526231810441201343923244441212431284192010691729021991610208251657001105525527701547422179778337043532800619242547511762876129112189814901147891048116295952157411103523354407421374051890371722301321006814002459200114930500100845700154516917032175415151710423440125197800119468713331022247096800005151609094080131840992391420130174272389384126301631126220103597258314948202962184544401638106122842318259222191265810352013201897047439215665621853522464042318228700206527320678170820756449420621401847044220039109574464716047929831883318412376022744119604182213820511508
SP146Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT212970012393123885026500128779044881622731400151758479210368534696430262430565232220318923231804227786018083849511931910429274820158640993129154001292289676128020400160126204863081920012942291717805285734000011451290110156256127466336282468687991511341252140135320327191854116101673001259363245703100205548251777423112630069221623711158224776745013888067710806714962837268626587082897393447243257834312620973222100709674281260190034614444124512260011913464015623618510500616340111463655822074286650210816416201627604492971913517932343103610009072011000015407500314020001100407529015011430295301948460300054247800001518501000005105303110200051101066100256450172099101320012204050130036513640299230060189762197026508415654100807471314163112805312008300026649826016004636017000201011001700340001111853114420033301002022139726032
SP147Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Slackia;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
SP148Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;parahaemolyticus0000000006600002000000000002400501810003000000010470050006000028000068080100000094314000001360003905800435207000027002004100000052000046000000501278000806900820434000000000002900311500000002700031890000000051000000210008032001650000000118000038300000910003550000807032240000051732300012118400690000021042602515003100002700025258000000009100000051512001512720011270060000101210150015425000074800014145247002602050392255400692301321227500231304570012638260000561221424001356201234609005740004543574230100003607891290011900300042004620883001331971615300070115314020980334140
SP149Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Peptidiphaga;sp. HMT1833470181402005953001947000255178101486154964647615062621404192580083778320370347664161440329010150989822719742493000834542817525080762495042415738304810001706372568339361296851955313656353453756271905767105897396021122415161072371242241393204528834534614427972040801172357173914243130120129060638508387584154159722253410451197242611641511474692027276460314795001114616132579268469016846048285322292204685382074025961016044819241493900384100220302304215254230169971952335470251823624372526875901318434565163202138021474868468964054722463326023171941951361131310090000000000003000009009225000000600001102202001930000070000007020300000606000214100940052360002140230315150500459110700250005101245042110391272456160018264030183291216813316191942657001021035242029280110002600700290111303100250017130053129197001221151906508614904
SP15Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;catoniae000274018191727715412770389037351293150040493765055833561386460331541631360133954379423555980718174602863000195219501598267921401266538275528630082108121361537005100329632161506813031250860620786107398534103729287799085520969127001266098326690395412106194875871456280157146202503859319476150174870200226131961140446582611011570757431269011914490154000011137500424243108091571103242016774243107974442090010301376440666267235401240718165710362891102153644990975605847340913058914450105716003015270000030290320025002420520700401100025001300010391700140014450760000000001100011250000660009000029060000200034900000145130779375602126014863952014227601428292048207373010620003221285427804860620210126880184121902072322681351033075715044500203810704385008542711041174164803690420600775151030
SP150Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;hwasookii21801018000001926310222562981170000032367000000999000861004546103016766567044011311722770030991859505271958244620480000034643869809110850022003233004009091570000242522202616025426450310165834914350056310307201045375294250253000069753580385046960032005580000011523500061300214827601076291901555801980008114217440479397206490241500005348250531365800620010940730001894443000120300111800200203001715917494403000581264601417380110000000002408140000000000008300070034180039000012002510380000000000000015014000002400000014200028000000170000000003701400103020000000017411112248000001510000056140300430001160935380938011600149471540101910120118000000331226400014009801100024680004400032015870836072000195153099
SP151Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT3060000000520000000000000000450000000000000000000000000000000001360000000050000000004900000000000000200000000000006400530001300000000000010000000000000000000000000000000800000030000000000000018100000000000000000000000000001115007310001821380000880000000472600037287002700486001012200115102001311103540870137600308000360207980002501000000083301200035500000133202300000032005784490000291800291400631103050001470000080275100020308825015400272300108770043100002496230330138014920056400051323254900591000000130273040001571010700232800300000039003731321
SP152Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;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
SP153Bacteria;Firmicutes;Bacilli;Bacillales;Gemellaceae;Gemella;morbillorum18838117118361538133018391421066460120917312637419732158027795413961913254388166731059651980384524544258415012138618138212471045112132401081254147103202684712941716016741122011683132548481008154741537747254571240036346354917071581255208149214660789421203642565453072888826910721527258114980014289357610567122033333987812864981998284355874152617853610363142280198813094246124502004288943675225631136113259604136250345107513991357916925342988028810851026293329508638137609722640646512841538100615099741694913464110619094787402143714076010701408143912112752197112795512012644012005035782441231770816356230623534828305132643851114276201010159310140162424000172837518511513100191012167066900332600010919131071354005061509025228003308117527411001329112912210766300418016128266744014410059275034270961015185320553680010820371205131252820142626136241110758892682990373169515070372313594403306802316188791703841249274343352835302467895347027457381620384103114016296713260459079918117043025354839912534039633603278102617106333401292312131602152400498328971009022161
SP154Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT8970054400201358531960619019366000000300162000000000349100589000736407028971949000489300009054325089212730100097876126101896089940000003716511158000088500268299004690025014220729467223037314010000141827770054080050117692941524378015874000770013681130000100048279017914800026312610124717200071891020000261950630121095810560260393033171489017392000344003676141413390021810620299558234604427400019137601874996761093445000027001597000000008000600000000000001200000040000003000000000700000200000040000000000200470000004000003500000000210001640022409564601870000001150040014152600001200069010163003400000520000029091180045000600990007001400000227005509411400180000417
SP159Bacteria;Proteobacteria;Gammaproteobacteria;Cardiobacteriales;Cardiobacteriaceae;Cardiobacterium;valvarum168073860019721946610111455877308741052031690203182846049802308783273078213912032201372251866261156306102053136647794711010286104201622125226063378091885126024288226524355134004020079459509920156129107267019995128715041814714262717251301311177168765583137869012356302373412501231257033762240449811526011501944980457021181132305010863130112880844901151201009143216397772401021126080267221454061110901039216170647920109066650610310556634787016602130014825670872035361291150316509841102277165376059317036962574442974198302293660118580030080003200030000000900005400400000107050040024000000000060003001120000000000110007000020000500000003600000037039230770011314902303306014701303028760401740310115080112400400121170958007502560241419400000001120410002540004156001601000700425070000
SP16Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;dianae14001200016920700000000000000050000200130004531900200150800000008860025858602710140150000000601201806290201005512013281967233012000124000004660013910040171225300300000613100000741900153150240760043483011088027000000144121500592747630226254206714000012016200164019119700484502614002037961124151180490100000282300000190000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000001240000010000000000000001060000000000024080000000000000420000000000000000000000000000000000001500000000
SP161Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oulorum31910233104320844342761001771200037006723408080104127016686613700871240412376152190261523776125126450800052617771070237358008432492116185572702209636000265527611695851544201117012991451500122300013176073321445265594406014681513459935648772612930505012418558854163114625132020362012152302797947353511102269914784209902511906011007481106273485933421212162459152722281591849602539642297500503808194143115294249454851533179432140237217511127360414363154614252869259951353432881622877171573814534760878237524599219280015535000000800060400000700313200154104000004030421630340000066000050310231024000008001070002276700000220720110313026080105780611230321013520811070141229015113181240444879109713290355067178111240950180012902629040195771115904802575156200169100120102830513511233130718033394115556729209617
SP162Bacteria;Firmicutes;Bacilli;Bacillales;Gemellaceae;Gemella;sanguinis01005594021551820834941947027401450442001770892823690102000634112120012071700050150159138176015110713306115724144082500722181134451551360970036014177160218701883270267000043206003262451172212402441509001414431101018170161003281167181344930050001211032110285030211133300715411124900362401629014837512000110114275813304635765201256772223304845767231151820135617547068127222227973293887397140134001363335531732610841027276652176112902659519698217279364741875706292071648147983795403971425463161536305731038827114916086441919291305665614991871226482226151077316305377583172490568119888725675912981104870226906109515236246625893341112723414261867328151417918014020882344127524983191102851516402120533949088062728518215348871577132111834928488288173025181331129313061285134932371126138069727218280215342612842170113246974446215535961905118640618819293584297510473570331299304467121351184823373425127335483381576923100929012284454508248641923358363513556063304461437110822410218343481401369822521228103671620249037759429539497621976491413979245856607344491007
SP163Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;tannerae13200005993015930087402051114300387046560012270048120163660002106292608999480013001400015395004367000020730271147000022218944706157160104029225272973008940238107839172650110003030491639486952501322905770073640151467130428630063055302432280022184424140284160013038890215236005915716001000700912291970960493140331420000024554290426724016043901832240012483511874528088070686410559431700214112026398122274135220180000036558102301208400000154301100830300018609818424206023216405720404107180000200000000158013000010200070331016024067047702810430021120115140017239000000036035663834762190604743470148260129200422434178112020231821284520216974103773028411326939160088030451120382402905002102559011790504602750672016601472081365832035791240207341515200689000059030323
SP164Bacteria;Firmicutes;Clostridia;Clostridiales;Ruminococcaceae;Ruminococcaceae_[G-2];bacterium HMT085126000820000401690003902000040003000000002101595202274210000004800733525500120108141002403412000110701090150083033008760003172018301142100090011801634380001301860491980510029180371023203000000330778138680801020000003700243513880017029726700483744662111700292630303171624017010410504333098900897231029204071080177166045913164002423262000111227912165022543403822092251541500129531199441821947337260010980210330326302711290023610891709034968604059500153228325477958722075360403932531212206115051852823032017811006412940027295119580131494656131401817859648524484267507310001042347917333824258554903701242555210805304188033243340075243791500966355600215150020575136109403236800323512442825216111175263177002082166802302832220766
SP165Bacteria;Gracilibacteria_(GN02);Gracilibacteria_(GN02)_[C-1];Gracilibacteria_(GN02)_[O-1];Gracilibacteria_(GN02)_[F-1];Gracilibacteria_(GN02)_[G-1];bacterium HMT872000003000054855561210041700319800301088028100000026870021186853107714520379064031112204401600000544106601601845019700260019819073050723639000000105402003351215518452976103077405331501613000002013612709938611000310005552038208229300000047153301499025176456016803105773005530000002902142034992881240026001012330473801381400000014660031565286841710016805516707400000000006040002000000000017000000800014002000004500300000000001820000000000000000000004000600200030070000000022000001700048007147001100011000000400058916340320701317006300000121000131203000006310015008000000070042307270004403226008
SP168Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;sp. HMT2032462001900762000000000000000551370000000850012530000000001065002897016404728002390022858000000000000001485814000320011700156000000000144003114000250060020000000000000000432278554000377401727002003000000000355700250701412039960066900330000000000000001025764700081003452007852000000000921700296006306001100140000000000000003000000000001800000000000019000500800250000000000000000060000005000000000000260026050610018200240000000000000002461000012214023007700000000028600480002060014100878020000000001600004600000440030005400000000030900195000
SP17Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;matruchotii1234611234629771083217532306343240151701730913024246859652115391785532091465425132188124634200894672134251636210438297211734017498622534174221450116908234541621102169971098945631434851171607945366161232638713493104741865914471158712904697442951844717604142147820328921316194891987611632103612046619804537920263866324502207718496351121626254741050745531352106480924930345194771862625841245299962983105307431974153383122613640121685649178761620111893191881571061348617395452963743129239017288756451878725552625525516625312875813242357942139813647443286589411150456766737540732472541336211149067253556213934210215410174485066378046793577851196791405722121116115021171164843494161385489901261562698914890723277418797911586144355045184952620499320013366913646515296297164201418033312332282629687774479580150701312632195181372010384215246061645217143661589211787683721670611331384991535994701512036001144305207400808881722180814201607617003011810253603801231020826571927300067100361006003501512526315058205010145913070814214610334400010307676302529181142331140459264827812728810030404992569497977994941837613721572715471091048452883902217613037344131148193351175311649073712177404819185167012490176212129687511351561208634392642511021421126250371454620514210443016914055151163
SP170Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;sp. HMT17200000000000000025000300000000014004000000129000021000007000000000000000148000300000000000000000001530002280000011004000000000000443005000000000151200000000137190000011000600000000000000034300010000015000000000000002780002000000002877105100571702355000930015076518510822592410825572661855220862702453983937170001150382552404006364580638631831140171229970798323564124720031221508035700110466221880008902168001207912263102322033118626150136310175766018109508248000315807135910942503060040944392219716683097118832704314847650049751068831323118610216500181290044872009130828722210160422854028157230266862974152900033390614780036611347780010096840624133139811227742236813830005888720242517330010512400026923930017082525973386329143440580342230503544199715590000225731800148658907022163823732891495132028401270217243430013175007
SP171Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;gordonii10922070612164248716973321793950604613503231952043129738185707117103332472482229536527042048441881577084187875110922601011105067122268994114349764947117425591238237875786212164001019525368224109628271327185951574089221693079983955048268496997472660254835448874484923824788214612209754825767501021313531114227225911677049411593100349270924401862722942036262553000121522052409123451082916774011272107813704631570403889209558718490161262506546294154123125082811691437242401482748864136746358915998019142011730243012004110148619322772229764322849450232928802057735999219494361931444311291605102340531778218452572002565611773285510955346003360014074047293835272110030071663110212301270017032003536127557045015151413317230391322182950049115044264124184810564944000011191017534594814846135039601990014160743007221444874256172012032044208110863179242546022934281832105852358101246900102406581255185493123558184624313476190174315922219320117216219391493095401801721183262245204259457324167502041632111762714071600358917121832451255230206194461191333793412802317411517835510574431879833936370744272
SP172Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;cristatus0007900007900002000000001570100000077303190061880041200042586400005000000133800002370000000000006204230103800000167600010106100067610888000000000002000000000000000000665033090078501632001022409100002930191000000000038500000000000000000001800744000002490002520380001649770000000000090000000000000000000000004200000159180100800012400007449000000500050000000000000000010000000000042902700007000003088000000479000000000000000003807014004000500617640143000281090000344700000064100003000000000000087050740009021003323014000015740000888000
SP173Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Lancefieldella;rimae290027701200187200407464213900640025702710262601780200170540053158621259316721066160274320011180010750046468821752539740007510545289031514216765244502808852420228349103437084176415684022191640914640680117001189244333443558130160528546128671325540179852111394062412611131783555440585082616148958366075641131071620135020549027246198206517443513485728054644109604564178758714432020572767092335882634911361249176454982122504002470106569987615272648230161740645422197971247704567003312002058521000154084001041010810210134446143502136908251631057930600921969480114525200800041526810352406514840652815010641131371610189830400102218929165102018118933787341152155129143196402126201122521452724051622703672338321352852291097636111819319566041170830230700166190318463884201617496667844373812037231931
SP174Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Eikenella;corrodens1032694165984918625519820943472466551889387893263011846208421854804451592735057202415026335182225900256144640115243385452695725280190656786136748532250188430428911000157130824948129111172642523692429410594138233821135141417791737442399910800371138395618752261562756132314951822461137632345618268613680100146875173108379742611961049214314221148206231228114474265452275467461648118114638040056235701647122734946197324506608304638813213111018292051403249464213744324892791151422662117089313542995992682442296425525955261188724494934174432051024174040810584172051004293194806197386411283817529361957478787308802148300003010120014212421411911073300663002337000304015105039274034002840016280000084898200040025509000134373300124450030009372201940514027800607004040514145224011218342832342663063720208141122373358101311471020852311211016712213167151836211412786140423731701503911241455535235387436387250104412096050516512235194316445132659076181900
SP175Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT864291019136000009001250024110400824875380360023012300920119023980296208611803660030001500178935001036000400103002671720341162014923210645150019376001360353304042300300000000015001048210110002001290044583532044248127112563259702103859289004504603040233492013013900000033503060840156410011240150002631230601273143203561293512178128346992560036601493900531065020100820000000000000000000000000400056400000000003900000000000000000000000000000600040080000000000006000000000000011390000000000000000402940120224900000000301411450000000000019190000000000008000041800510922606000000016500000007000
SP176Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;infantis_clade_4315814000019000002314032025005001300000002884420027000001702025020310110000034000000111202560011002304109000019056332094400040501203500000065023000000879000064032240000470006000258290069000191925013173041150234000106400000100000571000000017800000028672692200000001071039002601103346135381020910031411217621515103826512448997312437802442914605436180225341217732584985102119309015510839745513602219365122639450190785710261381346123383458279164636766619381274108111060618317341066213311003917977377760774052106113314048941530244626371074122952969802471835370103127724259316493444623304923713141813951604492781101517143740010628142040052823241917327718102185267811027122827512641396334340421090658721721125106223698123165390312202665216031030784418612065117635353656553240714682504179575014063910015994490264797140943411661048480229555665723717498813601693591723092747146952016489812890319030068037062651647012417612151432124225368832815622641580247456207828583722012396011966383007681663
SP177Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;durum79011643192234441574781824421715024223345564182393397043192588165333723064961693425721985121414478955084778019694880248756067934206152401556624266413816419192366722116260360816114226661805318464110770637392091421508409014810457927378947323498408645927127463012724763110021786610923556020842052390264720590319623589153539079081677613329022961810832301911499557341211869224225415206610511230105710630421947429270246534532587463018611512750222451236633303959347759772531846922044808170238257945753383229166088618351222161809136689242825108519600337109222291638360142311093415916015905325116924853750391601083502475724211066029591033265252713519225214096173923706142745251230534041212540370813016711231214277362003818878390212010152364591279535166822445001577228381291274414071401103333077224837029000105334203803464164628846189365271513524337060845699208667137726656503313197223241312951727036250146300203042001843992112211572881889402371901090859071316103326273660948342428121329247277059060257325211165101719203185019412105166554914067453124618912521463996286142085110
SP179Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium HMT15010500000000000013000000000000600400000000600000000130003870062400000600580000050400000018363900000005200000028604000252093531750000019800500051003000440211039710257118027000767329000346105300021201584228190004772170113019007204089223036774211118217143003000114164900051497071000000000000000000000000000000000000000000000000000000000000000000000000000000001100000000000000000000000000002160000000000800300000002300006000003000000000002000490000000000110000000002230000000000000000000000
SP18Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;odontolytica3530556311420434120153451451706453267028748411661053930061885412245668002002808210534742719922102342313229961311573309757990986139120116818258599132452022779110814381216101168105215718133420123587300108978077451960223342952761827811030193713954288383092306231803000292017425804969262764181237576078259015220121312152520342800118510331016218780995725136226408293015244512114703541580018958147311014781225284868169818176145407625054851010510100127950089715283163482346729623691563790261117044901044531368014172326640196454478916331943137445465193392401304429191462999428688155674623001213915607613431035735403125309691305367403617257152486183849823913396182736790106410255419586005761198812591650189223684962243609130580124201307810112400535432710301323818043831406756701075007417011945279945452222738644662698786781151696467149401971444079831128184052147113273594311440820560117624903464929366429922564382420004149451050530181427343335201277270533984718661825805733347759182113554123131001148094957174115625391905654568121315211608281033009230688549431120233413056700458970234701147454923630991825696414145293391510234731383257340301774214
SP180Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;noxia708130544488192941611949113320532715286215519612610445590233238730126260260104600638475084661305100116243416336136715455547125032567877501050763199177927040286532564319298611297891253856169836870038112583653037423286290126311322267870326673262156973251582271487199382611665406991489993798530803295829910836741194903608084535301522360149710351587352118311961695111425354398192276511921493245101192482148863300296243173451152351518127627314920262716391155197490277817630337121343781955797467040920156615241115010929217695598713423018334024427440905957621322046279098234162215161644184592094820255616387082488327799696329002000004000000002002000003300000000000300000002000000003700000000000000000000440000030000200000000001505066216692600510097113290613020123120001601172000007514510312308150301107303857218028236003070245203209160021102051044708043254032607101805
SP183Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT4986850000000000259900000344027970001100000200000003760000000000000015910000140030001100000605100260022000011700000036300000000016300005210000000000103380000031005400003430000038000000100000000000000016330000700000597000001899044021352000162000005080006004900000000045000000000800000160000000000005000000000000000000000000000000000000011000009009300060000000000040000000000000030000920000044000000062900050000000000060000000000000060000220000070000013029245000000000000000000000000000000
SP184Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT5132750016300031025107350599141400327700997010822340004500000080013372615000209500001202013538077005800061014405519939212789230900068033132700039000000200005616970000334000014130550270003049001701302160684943006150032240353615100014000000900214813490000000002880399664000770010950600544643477981058021500168021786000360000086001046590000129600004680003000570070001806056006700220205000285000000116006968000240000451004585003000001601613103025012001403200005030000002800153800000000047000680010310040240101011084340041000564077100001900000001520036338800084230000120017773149001720030033014613921083045001030431190002730000046400391580000230000197000
SP185Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT314000100000007800360000081268700000005079000042131029000002680110000000000580000037110053002170076565762009381400324619000001251883185030052018003108500000100000017450085003520067721000000013816610017926590860392000042406800200000017100000343054004300836001362039101014947800052240100021877336648200001340147605018000532000000004290030000300000000013201022142214402135085040000225154055001001402200900020107011440007240240501410034001020009753107084000006149210010061760177332701012000933503890251502811947044016170870004301410001170090037460006000013124151114380004532022207615590027021801290507853
SP187Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;segnis25900229023034012361731400131001750005721173600240010139600033519570017011106435277301170035380004960042902809054405654721100600430001049221001340031409950009840089335302582121035722920172900016700200101011001815701780600018000390011000027003236801503008909004204480434801201100023000016300221017940920543042223306700330001151947008000140510620004351300972154023110185019102203960006000073000410900007000052700000111107022390027880156000300130000001103970140114060000000012080200015180000700430270003190180002300154035500014253210800210004358900320054450805010500609458557300030008100057001210147409903791010030090008015100430073180360102000563216216024012990135000
SP189Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT38092904900001880154372203910224103811661557900402593401943002250015002492810071104439000001475000128402050000132081313410197000103211614050372005002809029268009019348007810019280000039000048809822000172076627204760733035993161329200645373839044804828600290506120470048000000196000550034480001290341888098000381701682720012106060764017103001339241040074702011910000080000009000000000001000000000000280000007000000011000000000000000000700000001000000000470050000000000000000000000032600000790004602800190200004500000012080060018000000000210156000130190000000001700000017000000060002008000000000
SP19Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;parainfluenzae31181133458714714964794067664275175660322386109045551291601087673637161619714453119878552573344642871212320022783590973922367934872450320383159731105161524084370191155688818933345450868711583620745914589856087033395010982596134549760675824782479304128391502959564177979965421344232001000025581502372290715123780095325771521105107346316752178186446317212422349822126604199274242771211654298881338138184752403767134011177136416721993921030270144784018612229230978475124690796270816941214921191122957149568931298258117225753010822170514739812506949845850174534557692272392053740881372179434331234767873832182378047261703575046404110728632380130127955542724513611378154472018341249325118038223745386375137144211131381320223753088704229541539624256535182107579119528831942458920929181367089872770887143841222688115302643178210488130260112072852933612290843005711199136057585157285760104522343104599040140311975788340381266527165789426678141286901673473009144232542817166210718868528193657548859553512844614250570160343980156382193692573486434698200119721442039603643565013148635440682213170491318172809936519333473783672295127711541559854880889721966377611794361320666142746934142336427741112781073878273517118581190481463710863251282994810561642162471865852013309708564998450552185134357073104516819190964141250921078660799498638106141228913348042219197911081443509321139744393012107597236199312120136428604334472523654931514412424021567594213751189388862133118141662066043192602378584512812537978310167411314075153256934507212602545156365360836966934820527144438
SP190Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Stomatobaculum;sp. HMT09768551105520000068402611501988000010149018006038417001210000016018130006286041000858200400122470400560540001300133001720184026622901579190000420301217527155037015012583400000001420012001201700021513351206349017015122800400000026404370000258012025003000000341790080040117700100042431117400840119161500427110001908270532476487761246961217140931641140042641550587162504964890159470442803110925503901008442212613529019911991060745267016510624219454213126705982337466542716111916945494300148722049472720801618270392540993174023039504550113010141032537138304191667103622765900010869221653558154711181216351114496363845051125802249066420311105107202560120617791119114578001669008232110591891018788030449434019283818749267933111904722843516529484169410872311502210702400150110098521016310564097049948003090042921668116101342005370498399006080391371084228311671043285
SP191Bacteria;Synergistetes;Synergistia;Synergistales;Synergistaceae;Fretibacterium;sp. HMT3602030084003000000274000000000100000035000070251140021600000047300029500569454000000015300500310000000010152800118003862000800000013510001280010572908000133003420091009100000000413477500046856041212403754300000024090001710348118320654570020344520910016100289090010500012720754900092008210286100000013770000000312000000000000000000000000000020020000000000000000004300020000000000000000000000000000000000000000000568138300030030050000000004160050071500130036000000110000007681000013302000005000000005030006005001240000053000
SP192Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;graevenitzii03000000000000000000000000000140120000009000000000080000000000001100025000000071600000000004007000000000600625003000000000000000000500000002090000000121900007030000004000000000030000000001300001301202200000000000000120024462767702682061050100748516918649420157960230256973940369145232284811306965299200687765594252192380513195051435720083142006173189524882569379037761051121351322155290232493265240240111271900942118349299524219781653057985540404218200934232481934101414010002151120350075531884184128068871266241434851365459227322522471223675088213037151024812374116410524980309131291383626266849200236587504601821959327785367391268131700759317848761505263714348087042781107296016017384818391860222951105527501852444108024051308639801821700013150328621472111720749503273647701546110016436334472170222007832121023325545258412743347648237239067617433127716261499613504109646988061343
SP193Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;endodontalis63700700000000012698003200000127000950830031990752006787000000587055246266700203636080352875015260031303000207600083331371000202000118509723700003260127101776397003523129224000951200213422905832185000082100060420648538730386424075015320206510830000001745075228615820026856623213000106115419802130059115000070012600042012757645008004531230100534900003978026530330210006243600002502101313016300001008010261919111004296061100311100000310297003516000041490380911600005002030161222001340410012120000002804124500653109112600528739151019446031822230005418809218082436615201233610001816102875459000509502012729700800662070027183624034500346109000240607235545338178020725601214502525920008032401422
SP195Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;flavescens77187001116004533005648600693614854577007644507000411340510000727521062941743432140006278127022670001414533060300042079004990398356048622952300171167000018253510000183013002520241050747217321800042168351487120682403141376231720030318415868100044501307000354798000011072975153402935600057021276104401949379160108000111781515007481805083358100023612490001041670160020118163903721785560000721492950036142012517945028983508491151908412871478001625799484241601561700004626885776035200120607804301765534080325307660760266110517631001331691210008736800128461703797731130521326406701182002584178371382001112104200345063951171029100676515014687728998169549204350312152844001062260129763220381200196026942228278314781442137322708190393426153658107824992685290051726256680389005808171217512957242152358154603480378204599431630394757364171823289430668901834582326061340819969067098945277673200160224274370006671122553059600463981043063225806211047092602610621399185059454150511126
SP198Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Kingella;oralis129718284161379111248297541315243619443256211111905332610025135850994453408120693832256116117671212847646210312183303177086522751863680236623712124375598658759536542648246779281235193117147028357831352219564271681275294279401366186685233168638610815311972038730256172080358147711120806343740242852220584241157804449209751371287881226404732121198261169923211038186277736813307903537995114085319161112297112701086129145816251006681496337296393873712001742501434291652431893639121012133279176888642932252243136506102110951371235282565697025504762411315362710523842561827721911496101670138926813555010967292498224191481127578226424152110107889575212141513031279006090180510070002100120235714427501040986006194897303520011026245783001515100090004100280631000501733584373165001646474443178634259401988129182122622641860157304541712150402102365024591378785026763241146923711284306415510770413014272706214821520469399104126119706061121310757066314250360409
SP2Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Bergeyella;sp. HMT20600000000020000000000000000000000000002700604000000070000000000120012000000000000000000001500000190000000000000000000034000000000000000000000000005300000000000010400000000038005000000000000000000001270018000000000000160000000000216333310000000000000000000017004390500370000000671900000000013815046000000000000000000000001700920000000001300000000006752745241121000000000000000000002300362309073102210000000523637000000000547183416884000000000000000000002700912805890623000000260
SP20Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;intermedia160400237000090000000140000300000069600000004600000009940000004287009380005000000001200000447800000057379000000051580000001566000000422100597600000000000085000002200000020508170000315200269100000021800000041960015377000000000000236700002951000000605620000052700010707000000244540000001200880000000000001180000160000003838000057001600000009000000000119000000000000380000100000005339000090032000000400000001670014110000110000160014620000122000000585119000372120014240000005120000004850016140000000000004220000565000000145588000815200305000000599000000
SP200Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT30500130000000000000000000000000000000000000000000000000000000000060000000000000000000000000000000000000000028020000000390000000000000000000000000000000000000000015000000009600002100000001200000000000000000000000000202054014000903267284067010587002702023353000017519801660000000640011400061322625301640164000250033831801630289000157057516304002244807150000000130000000452203329006201700003402314185010508310800202034294112000112516601294200800006010010200028341732530480199000960023031078822508000205010285640000184150474800160000255000000793056
SP202Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT221150000240070000000000001200060000170174000000880000092600000134190000003000000005270002400142700005005400000019000000000003930911009001100000000000060000000020011700000052000005300000042700021000000001100195800070094120000310420000000008000000001195826071620161004200000000460001272000108124000134903370000695053700191150300302000477291533179280411004400000040003960001059216048115967821007460167000059901080038041002800039117266213374703030095000000006100047351260171371000007580349000038901379001447360994690001555233275423021600208000002400407000610912203143943500032602330000804027100138528005000097656
SP203Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;nanceiensis083911722050020150298233125367280092741850000032360612287917207000107196714129002304140002060414472008151000912200744000320640010321771344033010337152121783600450266310500400271879679627015500273233152033730005290116017415000002291006005900203001209110104006809800414100240000420250825135117060017154264590596215565012544331861255861853402830036883101142154422189510355197626661144332377572216702544447695204455114216942738103681557041411532609165178942030515276697013863924951665631261112672379239967941827266144062226138720701734265418401013822043500111899138017832156191204127267461884710702404717160195542125738929086315914062222833163154549153121924954432316224808851521039332664184131132165086335221955022071164975257761045333531260208329221515291902375014011910829417556817825697123190938719897212203776231102523743126692114616637540453141088371710161261994109616790928019997112859332932071326010399
SP204Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;showae214015711411325343338100819608405962213146824636689781114524021322521335155600373410381611103266126010292823638164033784842832184263123010189012582572180113118930075300152147233454786825252275251458027497520172228893131603515821482233190905319091510105284375234586682432150610541504156307211622796612361251123620482314589943583070175100816231320159598389821646931010272528007693672598619399376100716061217029135911002394923311004168118071115100838019311256471751757312617602302308145182715835388053021312622572143314468757594933746635729731601151580202249790030706420103238369023294803006387874151441551145278620548193771321287125623691297422914163896000122343005101971802330300007300003350500061243517891301495560650019202045001431525800012689990120000841517005034000000078216194300000796041831375701497192133211501014082838247020365716122481149252046135050924141115687747178246253454171704623385945704611535038682972363720557896116051063500121456329580571001370734106233177551185163396845407837730514
SP205Bacteria;Synergistetes;Synergistia;Synergistales;Synergistaceae;Fretibacterium;sp. HMT359196000000000000133000000000000020240000190016702200000000002860000000000006800000000000000315800000003720000000000000320002690000000001790011000000040001194124000038001495001740000000000867002020139500000003000370000000380003775300002000642705300000000000000000000000000000000000001500000000000000000000000300000000000000000000000000000000000000000000000000000001080000060000000000040007123100000000160091000000000022000010000000000030000000000192470000000000200000000000
SP206Bacteria;Firmicutes;Bacilli;Lactobacillales;Aerococcaceae;Abiotrophia;defectiva0660185437608506902061535632734266311018616911704711797000812133863075521677231064622697573652097017570057320333830166610110300240011752108760701010200200023043823970838001185922113110664531272135449732443577933466501180024209302402360034022133272427217000437101260032321580000181885045502672261225785882143665590946211034417802130562570200040226754541700000000017512400185600077250359482024042109103372030021414111087801741027056087300009372016200400190080004960600149042048135962812017190017900171410809750688800001011075160155000003205252304601002779022406114443027123501013900094077027920675000035792197140217000647818096345702301128140105892432204493981330115382617372304651002303580024958000291492713705570000018644848205874413641513013681546125608951484414791015941500133
SP207Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;sp. HMT1785035201062234735027948711710361371881052611900157326066740628000624421586610017834017970142232469157217035622862127681093950414879101347151866194202026552015843771708708141400368266522559245117863063153981611520010833911391353637955281502358933284254418152309417115124165114601880553375242842535460216032602033381500029782341079012501122000146391059300691552731433252410258373136224444611850369031693438718962226014956164209019453490501922134003943900506035088002882846557204200584111238512351544901777229661740292758791610767340576000010000400100001300000011000800000000000900600801000253054000176000001420000000007008000000000801400110313007000207220041100768190681900394160000043332970070023601001814052142850118330028223005571400354302522002483220011001312519000117835539521501451998343540
SP208Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-5];[Eubacterium]_saphenum000000000000000000000000000000000000000000000000000000000000000000000000000000037000000002220000000000000000165000000000000380022000000001250000003900181400000000000000005260104200000000009300000000000574000000006300300000000000000004000008000000020000000016000003008020000000000000060400000300000000000000000000000001000000000000000009403240000028000040000000000038000001600106040600000000000012403600000000000001700000000470000011001430400000000000
SP21Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Bacteroidales_[F-2];Bacteroidales_[G-2];bacterium HMT27439200135001027014210000262170040014800462260004120107012139417337639334266696009619008270109712001861511196132200011912370968063137010828384748610721003027401471013901496671394019763400112780028930282412200100700848013966011220770147908420501930010617160002797623481662096438109624890902645850014714910048740204770838001403900120710570201215462719534420280453901461504499304598729100901705579957052042017134334025329501980317700252901643590000006000004000008030003002240002097024202300000000032000340000002030274011018000030000604000220030002009067920609137110401231018053933753072016028310112305240131762824203995403703100199211004204772000720013023820169412783060566800530008131470038000302116401038
SP210Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT3520000200000001040040000078000000000000000000200160150000000000000000000220000000000000004080000000000006000000244180000000000804140000019500000030310000000460006080000001690110000000200140000005500000000007000000006387003360051776100333548018041401284128333945904326673680752611082983498240601157117207549110719013277831300011945546212062516195010347180317183406010455375330501447112291458181124701433960070126856372513913211205955327513928120017475532228507821311870116698253461036272392638401376016013495854783203693078044536743519992171092118502362077817269104532526083361007631995344195624544602829620325857000968023950521576810007792270463564214021461490064181795139801145540026878126209166426413325644726335013333531970221099526952020271
SP211Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT3380003800000001050241000000015201001800013207000024000002930005100006841100210500002600110220000000011710217000267150000027020001060002000002020006723024000002102710000000450164280001091510000480009400171000480000584290013134901270029006017700000002070021000230205000076065100232000275000014780000000000020000000004000000000002000000000000000000000000000000000000000000000000000000000600000000025015120800000008000000030000000000003000002500000000000007030000000000000002400000004000020070040000000000
SP212Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Kingella;denitrificans00000000241002550185900000001481100370000040000601450004300333000064307000000003308001855000031000012909900000000600120000580076011000000000000000180992000000023330000000000500841140000005203003076000000005604002510000160000713021000000009003628000700200000000000000000022064000000000000000000015000000000000200004000000005800000000000000000000000012000200000019000078000000003000200624000000090000000000060005400087096000008604000000416002400000000008000000000000001500017001540000120
SP213Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;shahii000000000001310000000000000000043003500006850000000024750010885100000980000020000000000000000004704135250000902000000000001057857000000000001470000000000000000044100883000018920000000021004356094000000000088000000000000000002107513000003542000088000000575713200000000000000000000000000000000101300030700000000000000000000000000000000000000000000000000149000000000000000000000000000000000000000000001010000130000000000000000000000000000000000000000000000201000026900000000000056
SP216Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-1];[Eubacterium]_sulci000000051300011000000000000000000000000000000000000000000000230001820001800000000000000000407000000000000000000000063000000080000000000000001206090000120000000000000000018000211000187000000000000000000017000000000000000593019336075094536211259291284101363551039041302502603470217200332990118402561364106861088262294573389809121013401980407601259012710610273704583220117019755304811440720842317623640746790428026687931640400021128849927256806381701250705045181470133654912145255466883300515007335853545300630026762075403531778735540402267788896040020180530772931043260238510142922846311101010360123738830214583319003863302830144270854652406111274322165167049430650
SP218Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;aphrophilus360040041533428101653074001190059572859212039400035077126521628013900018870055552250598974342009002840649310323100000001859073168081130000484010405414280180000174000065106829710000007279172957201501930900648015921320178750082862504722421037000037200773134045342684000250079021250839000000040401690106090000601820041269201400002240000438055693000000500002500301000701470001000041780001040000500129240172300000000000600000009011000000020703400300007006080811012007300326900720190064002690229460000000181949601710533300003230042424141016511242300230026402202100200009201903100960055933615001780000302001684408712
SP219Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;elongata87151434149419793666304615417821048944644354057055261614072981120336125183037319471813683014700229508298476224931918373283001361079632680541209336321287561791076376411339751735417221396191191553111626941315930099001655412238619250915300052638010550015010130710571663085064101183446634428387051411526709334322084136236151284866434956558341121551442492084372176073976435119722349322315332768840304001524072641240321571432291871886491600508414066480737092011539855916929623164301125146908106511714448738095905371308753608180712919008641509401420620877015830261047109115816139227911603431014058410102593534146010282604271247150142316723280074703001170383810521945941405271728232338415132847310020342282525200831490971013038310015040081025815000155013472125843211873866731757531944767835042571120204771178185010186982323192127151351398021802090371753628691564529253203065367191751011296157331177908371953192851775888620971170544170361159102825701087009100650025405873393510604442170402981099580
SP22Bacteria;Firmicutes;Clostridia;Clostridiales;Peptococcaceae;Peptococcus;sp. HMT16800000011100026006431091870011400000000000401216200004112100000017000000000015900036014835837700026400000370055300550111200002811220001100422200000000338000110612695034140100330000000088200104093918000087158000000950000000007130006508441273890600071300000586006460049401123600001441030001500120000900000530006800362137123006201090001900142006023231600190008560000016800000000083001644001300966000980290000243015300703527900770050040370021300070000061000670058721117100530118030306089005011027800146001488190000120000000000160074105214123650053022800014608600100102900084004551202200201000
SP223Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;wadei5740018577202270179222119706021631754941571140810700821326961601551130304598382488481201106004888378933181169473207914439343272001946105540014144764556468523111762436019573699102501631342138010771288422331168865608640665315235713565240409017191730110742371372192183712042046413830091615251095000256760128125751823486055351862234966529426683442713223511253443059804688115283109593001901169038301984863064103201118912038213002115331601364692744165186719522931700806788196073652635212326710937372252101024224350177607672331875727173982141131271258065439935962996919463345381076546063651600002300000017083112070097010011014129043290371061620208614002742000006001501670000018090111827029543011900370074700001359042230380578000000200000110980391900227608311975210174450891119016940361990251004982039011183421245299000008936059648351272130013432706020331098261056140016921178313276039102095609425103329030001344
SP224Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;timonensis16361720000000574021600000000000032000000000000001725200000279000011170000000000000000002470000230000000027000000779000005500004922000000002400000000000000540000000021000785001950000000000793000000001804800000006200006000000000000470073300000600000000000000000000000000000000000001000000020000000000000000000000000000000000000000000000000080000000000190000000000000000000000000000000013000360077000003700005800000000000000000039000000000120000000530070000001020000
SP225Bacteria;Firmicutes;Clostridia;Clostridiales;Ruminococcaceae;Ruminococcaceae_[G-1];bacterium HMT07515100161500779164864867809000544102003130409008301600142029320820224420017380002865720241437563007351040110717631012885528607806260012249328610723020558007425044160082649426040531357430001672148050809172001824200483295671160099013762001562336110125186254535040338023530764451038902714582850001241900341682230008514605401623221379285594909029361390124004014161730010201966840375570707435096149107005959128980003722010387153130006100000396019002007463000586607100030751438817002552900014200770001529011023384246074027000016005658500630000011398113130094840002225003915001954138007171164840113295300282555945078202610104302394024541819515006112733441000342202328637001977942379050243332300107000477113020646150220001201723711802820053324690001213490090
SP227Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-3];bacterium HMT35142005100012036903072610040020227030703003303001259217042700840286891354063372240037111003001226501317662232946940173390190014403400121003025112364701450310832331583350223118102710902004503122180484371537927230301227804566919034148591999008814290363192178002168103110052531147081801000023944343074248781253824700533123174397822432153021183841953285024927219491837272704072230626422040139120124654000315789178961960721115041391154356510325193106216947755510256034174281502807560103811005274061208582104185290426300425611027296858626071544442111186946109001671233066008609728020362821440101204103290165654143903001206461813923245241815207359751632466337313832686701191098274642138223012701346523014491291012572225036147246154011181490073129233258510933739916606419113064407830060389644703701132980420
SP228Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Stomatobaculum;longum1330000000000256529000562003600000560105301307000708133828003511702660185376000140012633111202016014722141264000002492105799151460530000270281820616500006240138049758869740218006591629516671520701091181003260128001111781222001334116724025860025419018128670157009912727801084036974800010600634522691457041201824674124623001030841198255191182482313726753232150000230155271726322500046701362337143488603400651820014412650005293479500000289012940125111813559280000038401520200160965801163627967075113014200559315180013367500113652919004510085405015003619216119648839005304104061425000436242059255309255393909200251298230155226411002345395703704020304174983934115213825100100581041557006416121011951939615871223019200482361204043552100014017510388102334724708600133099814119339051640203261171022000281115047237302
SP229Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium HMT15510020002755585000330000296010011700000310063040000150001100523500309513700002451076004019000540011380313000017036723230500000303800972903000021712491101390073395640209170001422622841234004474022207165901444060011340152260032200231378206535000061105100500105463400069310561729984865016473420150247032414165502260000104024420046373400261929921800000000000000000000000000400000000000000000000000000000000000000000000000000190000000000000000000000000000052000000000016339400000222307000000000940060000000000023460000000025001104000000009000000000930200001000
SP23Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_subsp._animalis48601111800196441625263490092420360009290961000932767911090165016530149283066209422075637857121890106812919727900788630038599205014716322684879301631730037550426250106345316105139891049203077210481735602018527377870182811522148061023025034405222701179421119130916532695126728973072231432038542172177428154025827057023871629540873341736508521262055228524241640154211991175197398517094682261171232403302105714005260873658981281282229922562851046372161979101301239246680121118539778486875481113121267189224244261253951443378431145671240165130621629131628931481765174263249912833006821536371581127718511200002100000000540043000000200036171070183101600000038000003200000000370000000268003515200025000014700473700000340004200023037048012001044510811000946123731661952738249942769241412911929170342388019017203338780003873239024964300083160001188201255142110177792110291231055101108017100351200767737341532166226001141061802923298064000
SP232Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;umeaense53001804182348359651172569800003450170231613411228501813002603004970347319082139016003617720432159238129300172880010803241176941002394981473201002075003163459915855851205010342410140603017901554724000404640010421340666858082426772005785511078312545022765224024047973450080633079158443760494221010900159190174680003221080015912231691730166713700972261747254860623481391042903127917404932702033386256644033401190165500179803844390013784132059458108042202412014101450700040021000139000000000141053026037025330027810001060000102000630681890000002000000900000000135040300110222830201170006440050214000430407747900900106800027642005814900018001300200330304300191010000210071014700016040112275000071219010004725604203313000053022018018460028132000070260115185000
SP233Bacteria;Actinobacteria;Actinomycetia;Micrococcales;Micrococcaceae;Rothia;aeria7588514059391251269769131522104249415333058893474174727630940153511655291903102913651329736350122361121208181736441989806756630323737872012169331122512321164819510483227356643079610121448422323067254167201477733215416215146756918304497237731640920619974411141803329833169204213041558234399125380128115624963935054265513904215213165202754178549196201243116036219616821372327235876558506162860312028612376290903901574832529350115572101165418554493127230489065020305170328843302900103817383213870646285912473048017923293754506748168412858854517013583131804051242100303000544486377033583726743515374141679012651042531012654198142910838031510870806282524103264951353915869443773034100151882401211131699051030489343910431670266662967942422811703373103023881935131028250233520054400336510017051118920046015406970204516052260201996918279001012614152208016481572194902074553151156976654811562050145407431433614739431449505314445110726562203462925241351234521536413521264567173372235236131282020904513541866126188838631421093336417590141115315512115611175456490126835030238883660130378651533242322961059573463404164224
SP234Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT347022790151707127067415632407166446496441739620700016016020710004000006033011089756039860001161600212100039110078540144390898040911001130726096378352890000019802427650003800110211630124161433140021800052804520069345727003102803639985226726266242742690000481182001159000037210001004001420800572600975560001550292202342058402811931892210475721400000010400100006002036013719513256000590001401370094080000000000000500000010000000000409002060000009000010090400005110000000000003000250000000070600000000000029058043408000120105136551000000240014130090138039170150180001500231000982022026012320202814571000100000071001770000011067390611000000000120052
SP235Bacteria;Absconditabacteria_(SR1);Absconditabacteria_(SR1)_[C-1];Absconditabacteria_(SR1)_[O-1];Absconditabacteria_(SR1)_[F-1];Absconditabacteria_(SR1)_[G-1];bacterium HMT875000000240000000000001000000000000000011258000000000462000000000110000000000000000000000000000077920000000007390000000001120000000000006000000000000005808100001800000013000000000017200401000000000000000000900000002890003010000541000000060343004001900000078300000820027100702340025633900227010000033090000000330480009000000000000003210182000014003176196023140006000101900000003701860015190172000000863000001680067000038000623231057470590000316200000006103700690000000000000032002500301340289961703277021038001646000
SP236Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT0664488601424882363324475616241427921016101080010302080310501017011033788401400483206007841301000153431041510197047934003100160857810181418120905204013081083102700102290173016134741282412798280100011013339034002816411134114533900272740000003752122806169890061655640122000510010914880158057722025090190528105156573430112255218505006502092132582710518033143818113685450547313243500723527311275522919707848501121287126602534245749837191072565113236147337362970812288439802872306231932522042344183616676867415144947217122352775836250113903511267386356884221637280682942721033562911713195881141529155939816191128219723271347552711336420411196622115170515204521033820184710921476746324588792701197102412581115111648401291136460507918354116192012815141852019330143029981415401394010468872497503778825381595243133464076344964163145158301369180631681141111323298059777986899455113607005832888691510806778460117818305833546001180297428501165123547445579197566323013549333151841971202565734212905361077
SP237Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Johnsonella;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
SP238Bacteria;Synergistetes;Synergistia;Synergistales;Synergistaceae;Fretibacterium;fastidiosum1560018050025000037000000000000000130000701110650139000760000039208001434110000000124000005064300000050109102001650290400000011300001905560023729911001410500012003500210000000066010044070211440000034100015900001796495170010912316380002643117024007316102300272001390010305941207400707089416800024460000100270002070000000000000000000003000000000000500000000000000000000030000000000000000000000000000000000000004002008200005100000000000000005010090012500000146000500000619009415300003000000000000000151905005400000220009000000
SP239Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT16928658726490319374179365140995671103054194229783444668562122715276266891922949793954954792871550321631992561399440455425271494722299536604633321182585995564386393139188502635114114028135189423570573620872915694237272146589211139597133186570928537823765628972534953244110594080585031431649308025198733166855647167265135483045591116206779783815802164894312121790240981113369124715595212851801250794581618993782322733949140746675715000315235340524876743689303299612717994822186819236456853611920751042702971603695141410976766682103702011264623206183267316542886330106435257541987283101542563932664711828410114633171299421422356316389015022114317629414183203731004443392201478112725109761876537625761450531869901113101096311420140226370158229517361617139208075725352760520730021638224348176000000093617974656427398371116627270190341311452211361815818646367700179142632420227300291162271210166013001112134216474123683064911611135829123311702655735474139093518024406519197151611979092251935762471116520216753137128590288168156133291729866250255070645019838139812049698066292561371631005301079923381086320151439311214413083593352101081103507230123275021355131978921901067553133863168141
SP24Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT52515326414410021937315262303600734112400175204133750044350188003403326030215219662216380144815513560990410880183003188992339133804271859534046394493396008831322629837304952710944362751610773960475581484186832228427310032712957232354010181124205556612811122207028324649821782892418032761136343023117903260139235694742490027130354618112913326312560659116241231035037802518794136762572636028562011975163019575219323239179816119121011647153937788920915573734230476931928047393656661314396711321567212761202780462124885164444491263649499921484412971201623200318620712528308009823681634803006013000600004000000000000080000000005058000000000005000000000000110015004000009100050060000000700000021000658225381840818561601611009005606025111618103000161189729151098000013181303655172674917060025052001601100003860119938301100700214000001124707
SP240Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Johnsonella;sp. HMT1660005040000000000000000000000000000000180000000000000000001300000330000000000000000900000000492000000000000000079300000000000000000000000023520000000049300000000000000007620778000002550000000000000000770000000010000000000000000000603000000000000000000000000000000000000000000000000700000000000000000000000000000000000000000000000000540182000004000000000000000011000000005300000000000000009407000009000000000000000010000000001210000000000000
SP244Bacteria;Firmicutes;Clostridia;Clostridiales;Peptococcaceae;Peptococcus;sp. HMT167500000000029500001380000000202300000510000250169218001550000002420959330400000000002508500000001697003600002630000004869800190400002570142304980000000133201450050000000097019150000595000541130157194500330062000039002736115100000000033733034000000096800260000173000000211804001900250000423021724800000000001150000000000000000000000004250080000000000000000000004000000000700000002000000013000000000000000000000073440150000000120000000900012801527100740100000100527700000000049000000000117000000070000607129003306000072035
SP245Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-2];Saccharibacteria_(TM7)_[G-5];bacterium HMT3560001600291000000300052308721500050003000000018043026500000022500161000800000000031000962204043900530003961032200000140023503520000021017173002687038400000030032131306411522000153000105406940001402403201293000000274501746600027658602412770000170174400301564805397115200357441000006143024350680005205303440000006760185109000000900000002000000000030002000010000000000000040030003052000000300411030000500000500000500051400000002000013016200600604002830194003400014002500633013000862000008002200043062300800307600141303411000300025021018299010000119000008004
SP246Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;periodonticum0000000000000000000001700000000026805000000014500000000000080001800000000000000130000000221603800000804200000000000000000000000000000000000000099000000000090000000000001100012000000000000045000000070148000003907700000000010422066106001411001100028758500003684829018100000924101639138654727624502402717060600180143014610800279501190420100500002917000017895443830002260227312591044169872797000381000051205613302494342093300283016011730040002131020000030017830720000013974632011882571257802751043063000000522360034001395011025700000000153800006769139000800813758282060493200014310370205043210822139
SP247Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;denticola5000000000000047949001100000000000450000203651501310000002260021810044440000000010380000012084500000055966500653001850870000000367003117700802000000000351345019458015000003000614572070049117808896033950000001381051551040011312181490000000220003316602400965000000485813780000031083281441970000002570421450000500000000000500000000011150000000004000000000000000002000000000003000000000360200000000005000000060002002103000000001970474021000000215116390071306660410090000030013000676000007088026903909000010121458000500107003100000010030
SP248Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Catonella;morbi288005423232214434305294014037554227709923013821154221619000321220054153235766070681156346362307252266041178016417195340056596532872520289201492773154253200424227383121812594388204926470308079910767879005656313602603913229233683713271159016327746809639137729339252116408127474635990137197188738218854810401760594042238624122338875002570103518570137923060349170896116964803242298113399951885705991828631429164366161701712716094681957687320033866890985125408860147556932253161437193516101724511773372546681039303892315623421514301502036626443135351463883797311098715829098225225345020101748415588370062124724040410707205976250178917932361774613291502522740135008382269119583401587102227011133121882061261940065335207407218103051400411384633872813104431741673258373122103189248682001643826701540103379532057025882231351458456139738915916264114053167043530123099371182111725521622169971694671623832073167216635952129047162721227015540713621665934801558627511280258332283249
SP249Bacteria;Proteobacteria;Betaproteobacteria;Burkholderiales;Comamonadaceae;Ottowia;sp. HMT894000105001006400109689101900622536952300000059000603096142782140019090263450022117000110016003200107135400871603392322540000000660000000174128800705021914240847000012001420147870660133701902000291690720000000110024040610033170061643140313201599000000115800118013177300131001646110252400000006000000007412000278713417030293600000000009000418060002460000000000005000020000009400000000000000060003000500000000000000000000000000000000003400130638087420482302674480305000000060120413003404340064300015400900170040020002707000000000000000948002900380200
SP25Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-6];bacterium HMT87002723000005240013316169022000194008042000000000210013390019800000052088470371000007200053674702360000400214014300000000001312150010800000154730136310164900000657019121610427502152000250087000000000030000140014702100075202123802419000005450318022055710389000100080013100000030000219005360000092190306218039003280600313829722366125003530163792634004300754111523302867081434154110006410205941080180026000057143302160017900015347921211815800240009682400161200869804800450368360258542014300614080013010842944314915772900395150511451422310001600414051154360801040810138485790001361620200355049008500001091419153314019600028372275748418280000001449438042126097123057004572012920184537
SP251Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT149000000000000063500800390000000000100000000000001620000038000000080421600002530000140370000060725000000140015012014001302500000002007113608750133670074000010004140114037001380005060025245000011200000002604122000783176100290180480000260231533200800634000443041000078131020000000421031910124020170900000111990000130102301400000000073010000010245614711044120070646017710008213100003811000042000000042027000017003529181524410770570000103403623300042125214020002120003703778220000003013800016000241370207651901138032024040695324000129002500333180000229126005013318
SP252Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;sp. HMT25736008050000000000000000002000014500000000005900000000001660043017000000014000000010400200058436500030002400000000000608600568000000000260019000000014000145525000101200605001060000000070134007870918000000010005000074001760002113433000000056008000000003000000016000000000000000000500063000800040040000000000200003000000000000000200000094000000000000000000000000760390000000000016000000016000853100017000270014640000000006300340213000000020035000012003000902100090001400190000000000
SP253Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT39226100111692115167553952897100157210200148310180173422464256567351502530080015559668079303714939447131381238218939163210840067406440011137208240015642154147549061764111340974180004702435924757613711323467392909230789246049103695236915948425274641231868001146272148004882001240011774711516821692451320434347802715626017732510236635125088148202425430620108672901180127197024244020730489160948378801487112323001242132368858021515433976547501203503184022126762010845569912901471003380055172336420013437594272739260000355103483013994100056203050030020006150900077300704048561153063529013005500618000555510000215220000045473030590007000413623001104000050052002768221003983399104514170321330334003773026990035699189237952368017003541700102754003641121017001001950081109913450200516070970033380815517553100085600013
SP254Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;sp. HMT917000000000000000000000000700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010630000000000000060000000714000000000000000000000000000388300000000000000130000000251000000000000053000000000000041500000000000000000000001286000000000000012000000000000010160000000000000070000000610000000000000241000000000000
SP257Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;koreensis001500028000000000002000300240000000012030000000000260000000001200000000000000040012000000000000000000370015000003400012000000000000000500200000000902000000000040000000006000000000001000600000000000002000000030000000008420026586000000008640007003857600235000040005803280001230000130002281000001990073530000000000007001127550047021010095001600787000285000164280266900000263200455050000000668000900125188002270000721004101840102990003000073700000393000131700000000000700322910022200000124009503310002670001695001100000
SP259Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;nigrescens13320923483141678721310999064582879273702102014123190422131206481039470113631263434562279816819612962951337095481817881665873032371940370615946784862024116237621993646469386266380534823362194381558017498434356424072108724551929228324162751047423582507131682160542015761644321751916308724812370202005895520395718484522182289581101231717131820419554484225075473719359221142312344284110925201711380482143692239302510374272852415431151410016796399510053112653285740642779222110315930332478545621101246305771283146813324247027936656486103211603473645887027931369290873454819491685551648651383331113262216052310516712428348351891533335457985916361168211107859178998998092939120723236579131774222658129700251805725107351223512022105130889736690113471011381601039613714572991769058893221464201301723020470050668644171948120484121620229279210215744026518533225903927388736941868731340639760628794805401577121763689513791331391161181846227926234185411541305125193541803304931387274734342826229593610824353141742077915739821336023112613124012928297575529139111210138371812771372202482275641107136462375063271249416149
SP26Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;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
SP260Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;anginosus440550020430604209030001089016250361001920221734906021011004877231976004203121002658901274303366026350702002173365204473011171629020064138222155564201001803374192603600054021008738193717066711251003395015150501202280133867016816906749011001147581298283264740211099007210153042220712700349917256042273323501676864038430143626830017021341064220601432834375704450041764540200213300402919101221040446206689210011364622180173111541902401952060026171015032260500010703728831713033000023069009030003808313130800049160007454200740138015021424627004002010520900160304195595382933501103264102532680127964066811055110583102255930615190381324781913200213323306043582013312092512182711694043111440120625016306646211655101253404024332014466001566330361043
SP262Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;marshii132000001226900000319000600000021000000000408100781060000034000061400139275350750000035700000640531011000023338950000016621001100013092000019100224460025680000018750006800000013200090308811400009181095940000000000256003801302877813900000194400203072017200051000075146106700011093112091760006901300000000200000000000000000000007000000000000000000000000000000000000000000000000000300000000000000000000000007449000000000000013060000061400000000600290300000000160031020000000000000000510000071900000000120080700000000
SP263Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT34827200168007171424882215347012244340007132963015004001066000013897451728184510390510424231522420201258300655149466900482762239370309172496481212069228007215100435320101034127089505143702750009931080216148578802911257679285873601390873037513301820041043375020422715872162390308118433313301740677016441105204294084000406241101280640283143043914141401662800618375509001436770110764719121119177908658792561121022031547067766509262218074000202232620915001990315732370183610700466237012572420000000000000000000000000024000000000000000000020000000000000000000000000000000340000000000000000000000025000120730020000024050000360000001600000000000019000000250001741002805364000000016003000000016000000000018000000003300030
SP264Bacteria;Absconditabacteria_(SR1);Absconditabacteria_(SR1)_[C-1];Absconditabacteria_(SR1)_[O-1];Absconditabacteria_(SR1)_[F-1];Absconditabacteria_(SR1)_[G-1];bacterium HMT8740000003309294783105062271700015077340019009105001390251490389681046548912572000102940427610000001702110513270580900003441334951533226001780045427000524304011728324507340662004419000000810791047703833283040026221422490007974006021215833225609321905833504500035158012180000000000231776208003600026106138001345260234003970370421200419770401130473503046000000000002402103000104000030040000035012123009050000243020000000000015350003000044000032000000000027000060205560030000201051204401760345800417800012520230000598070171058721650008473081870000208002625100301540001739003167012000006091660438068052058255000
SP265Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT9572662700334040422549379457622436906062729205095009500215003241181592261735305398341265960013264840032213161271540000005330535237163219101360004196701361103068268095117905125615655570464242301016331510441300025611553741120047015336613816435841322711718640821095672307784162782508432350312405185689320901931603332918344641400159219828538500253834675008901171385318970130320060383482811714847102348263084671110444301033843323127172217174000315757050000007603700600000000007104403022000054000002050006040008002845900150000600000450230030030206200000000410990065410015822614218050702660472555019160480127020112808030350000331170045300143034118550263000707000160782030201232067414801205650026
SP267Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;melaninogenica77658831515226457844194625472400040731884110673006131000137821244130323024367827140302578912231526382443126136192834126112643602237075235781590190197727926234871072151060000145842885513259298504744019733237139155843422210033721524985933884063900115181171842383107817802420611077427348633584872002466350318251258401019610520871941019493736161371311309872133391767014099628011102512743771461220034735342621461376284174234624700307216107494885380378664810214084311862108946703382835216564598961863666657526854744038961130316598136196225448535920061216847523325115673594933311467335436053154606523118527081156311242824313456826418731250944517848548013622591712011466298871181011443561138986581082836418953526784265511065001931512650132691581134888201605491598750703975388557117167329020961734351681890383247615926600438311408112452690111234944108174087571491113222083186768691125132161302520311644461003031772549211562203904350914906112011001431754091105434011746888431702255197705438131841026210837474013090060145531453811497155512283753941276130007461163976960661808082333637725501025410869038014499636370834105527865746322447956814369184235054228469542883661373796954085212171876873875391345543075955018673397696426256176286240817808526361710521375715112912591173283301717110504273519143214305
SP268Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Shuttleworthia;satelles170000000000000000000770000090022000000120014000041001500016000000220050000333000014000005013804800000540004104035330400215000060061003000001671810112006600000672012580140807402800111506002540023004422170010000892001000018145707630710110014751620660268010439260005335901123540211007616801030149586000000000000000055000000002716000005003000600000000000000000000060003500400000019200000000030000000300000400054130000311000405100173000002314380800293010100433805110000001030800049060008092114027053000681510000081101011010356007309077
SP27Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis_subsp._dentisani_clade_058320017974391231171312802193021006182968230169902668245216571700147320186400009471217102059441748205014045120650000009416100001227650075351902130042190140390026637182418762764910153225421140605001916081700671796605091810930239196500061166600202629692061993212460184714234980443191222615975218101861267505010500018921798998441211683920004311750000001546000019833242116140331270528604081008700343665324910539342910953008553131401105519000903800100754000110016002251011022320813826425461433804003042317341001982840780033814363413040999242200173890000422650104068090174483201217201883862303984019439182332202829524010070015727401787617292600128001041355015007903139001112234312254934407019110446310315832740364731182549143066221279011000513648174257039471059063115511800001400015391604122972351058461254185120263316032323012663371139226147035269246018640124343225414461897420918169802431217041082944
SP271Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;aurantiaca00000000000000000000000000000000000000000000000000000000000000000000000000000000000005000000000000400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000066000000000000000000200000040020550041900000000027450000000006000000000000000000170000000012040019100000000013330000000004160000000000000000001020000011002121002620000000005340000000000140000000000000000008000008003107003920000000002671000
SP273Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;concisus56510159421355094706384171362651126249262289172315171144677014416033928810019862691249548928801777643137827790221854064684720322484567754112229619333269340035415437526741842104161245382986449446665113722472202741903141911051510688665204224641171873042012996312390466252866858125726338751586321054168326455296103458014484321232453473823369635198214835980017480505157967902674611415624882108960584458720444332801313035344264658275118562141001238801202675118572290613627119543143498222409584270046325636341931119144050304252865291065118119936614711684393355854604553457819303812655758105110015221682172774414963249657133474017228412941522521861050591222265912451582239037122831823018614118355621011515977789365104943253426522607318788817356983271173572559432137256544920728619419512102861443873592122441498833331843215111813532328410725749977634699127120128477717512973949202962235523764146038237567826552912632162826102726459545001501161824835014206864892861283113441502254036466816276802344094302432051305345902501094267692841244551064166813855238142098969121133599138382063311157861565229113203106167443453156444664324193811311263623661365322570962338147234
SP274Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT05720000000000000000000000002000200000000000000160000000000000000000005200000001600003130001110000000000880000000000000000000002500000050000000650004000006264909400000000000000000006200000001330000140400200000000000200001540099194000023817923321828916394101393031410349948854014822200194551301915242129847810850020152415439449905018490064196334001865260015727373618380516730595430015015911356065464731715029729203150115304723137800351984364389354665051430192711201316229000023986498333491855141618307744685202155841396008705290142073242983506580019830455646303663028100281572000035645000331386432771036027431009210260656256927001641780431356960839264800240341192923671892071640089
SP275Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT863000022800018001500000000288200000000000000008601844004360000000160000000000065000000002373400000000000000021540780238330000000000000000000000000000999280000000000000000360237007000000000000064000000230000000058523800000000000000833011038550000000000000000500000000000000000000000000000070000000000000000000000000000000000000000000000000000000000000000001500014000000000002313000000000000004001500220000000370000000000000000000011240000000000000000011002400000000
SP276Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT05630005903555103090013039563357000078030102661055214710022160350499074515190042400290580002136820621003730413005750912270000090181600270162216800128904551037002200270030602372061012324684234300900112613001558231851256000006008438611758154412000123051824303903260092001204900015561161400016261224200704051627000004904560022392020001597051640000000008590278016078824700000605009061456000060004000513120160116060130000000006009000014130900607000000700050001520070120000000000003806025605007724120001310251112160000440002201943300140250211102704900100090940100422491600432655700195023435000019009170077593701409104000003002504400870134120
SP277Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT847320000000000000000000000000000000000000000011700000000017900000000000000000000000000000000000000001290000000007400000000000000000000000000000000000000002796000000000371400000000000000000000004000000000000320000360000000000000000000000000000000000000000000000000020000000007000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000070000000004400000000000000000000000000000000000600005000000000
SP278Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;massiliensis506002023112788249551333315639945499821184173051517826354738823103717863121412917106921253684014557295110111033759660915686772149388458417219623871860784534911720773191090825010085601523436184851571289245016212302211364908202841392886252711927005085335637891372264465017973476014412993143415653397149507196481221451138610483985462942711413275174025454105311428240445700223728263493346027204004164617242819792492228029408623922034403611012170522813306013362284131379827107006564842800219624935510603001167910754393133109350109328931565041155716813720428823374116158944942036234346599135153831759941179994019829056379150285124047125520967966239552111389454791711245297349469341124129198994479471114000000178130010008007609883062413100134264000230521008060000900280502805375240179001378005901150078781300120960360250018110014220038834421513846778196411554135203124411455346213811202175237011351040282056164558471916413792201079560116205837953417311119148671232010103334197153151158450482220127202812424714130418969317842156601516
SP279Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;canifelinum0006860002053567584123133000000026392877626100000359000443177354620145085000090501484000000633000711476512314399600000038660857336120185005564700014607281887056053580001980118000000330000991124717829572000101008158132959431900008428000543012181701440377000011000187000400747000894295101304119500000968426398951113580010605400014439110391031000353080002202800000000003001220000000000500500000000450000000700000000000012000500250600000000015000000000008020000000004000000001540000220490200000006505823000009000020012130150512000907000000330110714022011000000730850009001700000022600014230000020000
SP28Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;odontolyticus3629304104300021160001174811712001413600070101403400001100009101801002441000242030024000013000037000000043160017027038032000010000000150188400227410011000330320000074142006600251110002780718421000026000014123902700570000800050000700013052060000170001670620460600600000001412002400710566781824440071201571860104781157760105843000171888013117485934239194694174028583624679315928114081214035065138734346521308074031632303459823335108815897312842137335368742458140241420348863290564410332113570971259142913560600759562997171513514975453219847377493926253028503716137910798259360123154875115763974201319771396152733678674218952334279062710548912201788929926473432024792424307150115213585199472253960114771228139265818042327760911481456105149837903824951330507371040254837263644099432015396415042175721488331149338639154842084566868942873566161337331305140024521172229376862486145412583960675238293160638174032230580637425652025731626103516507296047824525321996416321275124611180751232757169143659736
SP280Bacteria;Proteobacteria;Gammaproteobacteria;Cardiobacteriales;Cardiobacteriaceae;Cardiobacterium;hominis4350123913721031222725071851491131745222772601115936161780332121054236526703123244526851280423139202875451973409784195210723756139930725811357553400199121128915325765476216696258920319846854413111265224158210272691773135311505871286112002105362314911001206463210612193127209751991211411052170146365375910772195472191202750155410518211566582120315681683199393067363224243623302482758664721706174960523115081201922991752685112614057948971434237059110476593911634268210446896637806221243793010140101489225180601018127185030021302266821473243150489105950553558104528672019431386307595481215235401147010869683653965353320144312961713217581932681112031244732129285172001772150080349010002101022002166039106067001205058501218002500617504970181008500008022900017160000004300600011711300503405551122008040821996922115410549118761301927020419421312851641650191826240181035614948152786901471394026018963501212506950144218130378695706811992217065590439417581910687759154310110763124443
SP284Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;gingivalis00030000000000000000000000000000000000000000000000000000000000000004000000000000040000000000000000000000050300000000008980000000000000000000000000000000000000001863000000000013410000000000000000000000000000000000000130260000000000100000000000000000000000400000000000000160300000000001200000000000009000000005000000000000006350738000000000019300000000000004600000000340000000000000045901000000000000152000000000000045000000001900000000000
SP285Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT2251800133265660405820057185396700000267003070000030000133665788937432919423720473585790189568138504271186510001759586060000174985223001500127007950210002190004012165418232439011589178023814862421255156406120157558114001852703460250043732140040070000000035000014180165206182231820030731889141740336051228440014717703900006472770003100650036021000203000491074101984896407013069537174984283064101729570005000000090480000000000000000000004002301530000003000092900028000000004000000000240140000000301102208290007009033002613006510000700112117000000120990600020000000255122062661500270035161504225600011500210000141200000000063000001700000441780129185002400002090040
SP288Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;baroniae00000000000000000000000000024031000000000000000000000410000000000000000000000000009955510000000200000028006500031000000000000000000000000061021886013600034000160740000001680002900004420000189000000000000680003411272870000000410210004280020100000000000003290000000000000001070000000000000000000800000000200000000000000000000196000000000000000000010000000001330000133220000000000000003992200000220000000000001800013000045000000000000000000000101290006013000000000190050000
SP289Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;mutans454481240008734000000000685004000120273452760663001710000045194950329007930002800041816180013600114800174000023227100231013050328917469014330020050051532215013820055200042101000512241701340072200175316005006530076901103176014633570910616200000130098314993035070021080007110005716630300320042280000694091500014609309107315780346900460000066816181054100080021900081001302000016003003000000280783092300500000321202100000050007390100800371000030000002003232010600000002290560132000801030646015212730087431331006000010631166476014200030001991160770942240045010654102901210383100013990002522002000132252546028332804000357601592403006203
SP29Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT17164721544196243211133815316229361057112169670711738921397969223370470292719129473407740304410236465719482419004891221450525263166080818759750144652714200233614100910492711080103205197208164221013449891642188962078353111710958104359713617619364543481287431644314711781065813987389518341710829186257077622983479713864235985387231339435232362017322261353678286660386227019320671388309957325772127331822159309301823916911178207420071240150010156111410335901453120851188056681252203343402981941322439360252160164203380556291627250614977145618659517060587725568397369643202141008155119919343115638179839651498862600143640478932601305801826070000312214311359041601111060180141104250001219016577043017158540110046023063970366573110901019312361500270012010085151114076046439825491402745432571982124570471726119995918001215178122021442112623062821837840624355593320106670102913031843384803254613657059209430141127389178681449370627436541352394144032144534704530340296080550106246656
SP290Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;johnsonii1251740211043373831039644081247731259289923315014833711363125312701449185263302846853791326233046631192805532544456462275406820171324653001251507133984112152160170685532628997737142922375246397225410475159720081986001216290848614102620173352015429002923232512583541681209260410458221712531281003216449218336179132756709521827361041388123444337975203508407258542725182419101866304014410061355326374151711053212352728769403825379219317894371563810341206955611051901191540186257601043758150430173411131647348671306617130155415687260055887542683931100178321211158513955822937191625957722082257000001074003900214060020096028008040000021618003420700000184010044002200216014443004448009005000000632556302000022813830220241504211305315864043713189022153421001338010101100525334320782591600328162328329060160391646276451041640322300141931047007010802519333700280047
SP291Bacteria;Absconditabacteria_(SR1);Absconditabacteria_(SR1)_[C-1];Absconditabacteria_(SR1)_[O-1];Absconditabacteria_(SR1)_[F-1];Absconditabacteria_(SR1)_[G-1];bacterium HMT34544009100260391630002970003805527000300000000001644600112760000077760097700175001540084124160138038200057220420005004650004002468709900000018340136168001440045802086832150373073624440516940000001800005804821094850271026000002477006314100800072800213114492101830177000345825100161880012050000021401729000574000002850130000000000053090000000000000077000038282260290023000005600440060000004100000000000000000148000070016180038000000300040082001005150047030000209150304001110000609010864169004930100005390024250054000001221026008000341700000012600002210046124001520100003841000
SP292Bacteria;Actinobacteria;Actinomycetia;Micrococcales;Micrococcaceae;Rothia;dentocariosa185879211758758811442153706368017792788427310374157252967123614935129071891715333639519152467812623540814176242597366305378214721840215415805129258246710326662802652153915754390140719620287617616872124483710149952201725649566613538828101057517535441148728704621856180583608598614171648775117834832983710191421756186290061832772933084272974141746165131852991376142223894206291017202941002805229633835911816259934792422323883786376049526817117199485382896210230685691544955152408866448627351590546380913360124931225417077320011131003948222435817612111000012218733243730813641754596142277812788869401536261504255019427043925733380438011912631709145620101101411449676332965276231140862287807192121336567012111139277535851124065802152194512420745331321745415879751043016183171772020025316232712317295683618581658489101156107345933028939674122391101193094304975141127178137249149691271162022931256253984120912826385772321071311961144317215418716446215191172940323976402024430260422711156159582681657512485264026631945723392562415144722136583091107182634869195337127437510624118787451227746232154271180124723815917821702811861731213175223559050220925512204716298629833639846399414181593411411993823018919751032160349429185729517224059771041264627658111711852009332261183158545541431472592718170647204733312278
SP293Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT346785360769185313213021910199320066528800306027224850002405300992089156019919614151325392165281100049609344397043548371876813592618091752567464883274431115812298795704287081113182673631481191607875034501884172999571136616601896521251812216017047929551472727335121316945821059388647016510315217854623125951820114771453814162333700005666801268185043876468162883715302097810778197215319337441001057357256519902607688726000928108620373946158814726165568227383187967542333598257217172412965759821568185051713106051522452526276919122168636881111217243472451129806436329156105541581081539205900001129003401200000004110000090500401100800038000007000600013540000050071801501170048329100350012007004139000009211270010341232641721193231720968371376171217191144301131080601192649440717833001320351000109570658829753926146043051391820710071404016620314251025311121847011997303095365531738
SP294Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;pleuritidis10660000800000000410000050000049014223000000001260000000025415265000006015071160007019500000000012031014114643006210000140520000000025226660000180301276270002150295000000000003850103257489017400000029600000000216309129900003200000142174000604240000000136065801103682970503300001690990000000020490000029000016900130200000002070227110500140000001619000000000500001100001300060300000000019400014007000000119000000001340000069005083267305780700000001810011092214137810012100001705441410000000123819600032120160182790495077000000450521641892060120430006003203100000001022
SP295Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-5];bacterium HMT5119000160000000000000000000020000731000000133003100000000020940070103000000000030000219100000033770000004167000000000000164630055300000000000070000000120008152740000000162800347000000003068125800690027900000000007600007330017800087105000000381250490000000014109000000000000000000000000000000000000017008000000000300000000000000000000060050003000000001000000000000060001605000000000005000070040009000000001783056000000000739001608000000000021000012800000032000000021268001500000000225
SP297Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;shahii000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001500500000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013800230000000000000460070000750000826840390465000019000053500000021100500000032700000003080016000012200006170029438300001501590050200000015004500000140000000230001507002300001361807048831804001280000107500900034002200000397000000052500115000013000017642020176800008303600989000
SP3Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT3261080000647008800600860000406803094001023005204160009080684513205120002180000853044300005117230124002200090180001701020944001670018943510001269601440275045200026800001480213179000094580000130090000026023101008003730024642490001090001422152058800012200002450145000060615160170059204680000601390310006100105517200022321770636500907000470000672000000000000000600000020700240012000000020010000000000000000000000009000000130000210024000000020000000000060000002800000200300000000012002900110000140000057000300000010000000000000042000010900200400000000009002200011000000
SP30Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;denticola4920148120001144000001380008500003700022200418075026165251011531817380000900000140241700006023780020200172623131622807803791844410068302592367642450012318270249001991011400179380096684223104757000028600054960026974533701022942909143293017751237820163250205222849505477526370405914382216157000122200006743154601629372840731101952150207681229101363340468303262482715925536064431022196131816439338041179621901202713781290247346581271157337200861889150012971162100905210900460013012700000120043939019010827016081024183000006160000163209408675001587528126000100170019070031258020051650128539070495022410201550972660616111710016232853019301080344310960686677867114319108823610027901681631343619014256701819084744405718702482147150095378131498128083029837110295901416901533555401942941161013727235850363273202482
SP300Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;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
SP304Bacteria;Actinobacteria;Actinomycetia;Micrococcales;Micrococcaceae;Rothia;mucilaginosa31817152141201068126875824342013013305729614713566114019601252796404015519750482211442111225069156455360111851512381494745613650681120125376342484594850854581882130312315401335155819180184164771796827110235177121212739281211101962436371714410661427361065423060108026764110003213122410195366114939911315833973241502719384185409190523224621191217713013293210214401824118241653881650212211719500187388220025465036655815310527261313229335516150911158146992045847911488949473040205418768140121894420024310171792195092144828020698717952105942910134937296958417581202091655729656998901617927369745868277761072620813284887364129052855510240292641024416827220151313610424773416523349984910115633171531304481054874338810271690114819541410527424476192491682416104403001085482369950130101684911918538311830150471610311221346069438779148489396447215114787816447388144661950266117354258031004597792564835921200888862661318450150564114610938667764774869029231055749024130116618048103235473462815866131588003475754926561369315841231212564380229648545649376699451038829119073410616395872989972125219303038121609038117119106315414470610895325473126055251154633426807715791353464019621409207815214692614629737789811271232983158290419398934336614604746818860141618193032102962689857731645642830371023216978477055364922841057258594550
SP305Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT064295136963255790103976096510368309471572145620703916404419812303379368606263813862492634300163165649035515102332232499685605094110241210231291591374110034310010584200024921302992334966329300000119963212071024106965622177898639386013559282191921037779575130564212570101576315972075315231430250254800937094004134365365100224805231715707713016810014081836209419621151002691202103319245910222571059116493901274652103668870196972011120037928300082333255197415841100002645379132226211147200335426290323498428834519264807565821853753201971153517596617263002950548811800005402426174389201229511810021102121770281510421112016824651282709172050363832345004038200116781170022706849640000808241162302711040014303870055616151837692482441310102106764271408013144125363750237282450195101782093103401951247076660250113520712359344640143511588391446261463159454667883469615602601197109289811818430165112152568218977982564447760238600905051629427710019792769643349026270322416680245812451089331151353734344211182593707123246177291401232094306900205313292119422
SP306Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT9371680054700000001600000006101700100000061070000001010000009000034200337066800000380000250046801260180120000013800000150086000000100420770047907700000294000000013080605600780010909000610014400000027901002640020802810000017500009003170711000270000014700000250026900000062039000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012000000050000000200000000000000000000110000000000000200000000000000050400000000000000050010000000000
SP307Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;hofstadii1760004213009984631296320413601536314185001205193832114490372419290013560135307529816022973610014573527849113307250011262820377400035200222936275185247402752010542405001580213210812028029523881015502190024770782285993201927300120623936699002465139400374964259000200036778213035923620447042892000910521531640456605840958284401793060503202451350050309713623970700014528082200011200502104312924590827203398200663469018300228067901642612056401224716373371801590043244603167044413860040922800000000010404030000000040540010080000065800603100000073000000000350000000020000020700100001438380440001408500000029000016000295160111982000111115011967081600017068673750872436001400151195500000091220901301960028057420720410030120714744107100046047004100066
SP308Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT27867002100000423270012300000214032029500000000077830402251870000000000001138631004590000074001800000110625019700000000016320330301000000015360000177226008000008530001440000019017860320000000006084900561560000000000001995100019000006715614000000014036023000000000157543068337000000038700005500040000000001000000000000000000001800000000000000003500028000003000000000000000000000000000500000001000000000201000001990092000003204305000000000569039590000000000053350003070000016500000000007600200000000255085000000024000010
SP31Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;pallens270128600000057180232600001000000000501009000000000000102056009600330000032068360016358000880077000000905700050000000058028004251100420003012338314990325220004644003000000150700430000000009023004360533700008701045474002249520001223000400070040840331700000020506260801106180723837671434305031531564142126499414502211381891333014413832337173443250134661501317015472214982207810326211384330506449043614216581245200461496205317312334210020839022181995781922043064414592026024614859415910211307793901003545051801537411053685860101135691175189873028108087107541378464658187245115840082253844162111663747378879229323371115116140123852575836385722851002277167302042038096911313449550653709179511594698310029311263947051716961372333521101824630759216017621984501864028855852119901581642402284918430497561130100912780875019913914352808151027199898214138935304585373413290
SP310Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Mogibacterium;timidum139000040000000000000000000000012000020000911700000012500022300800300050000000020000000000131910020002024500000012900054000590000001880000073003800000000015154500129244006600111642000000329000463007674667931000122200007340107000014600002474000000005004509000000475000000405000004000080000000000000000113000001200000000004007200000400000430200000000047007000005900000040008009912500003723000015202000040000730037600502948000004000150012524315003740000123015000000000214071320004056700000051000
SP313Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT335001735139720223620218577938713927991310188003449407000302003240088529705572821852718028705500378086800000107510266018964537754216311643711027012710061382028000453260372680166000301603211600686028009530191000009105130088282518043691582175105630801845001150239020200998190044345130568570159712479005850600638015100000290640510544565821594637122721344012470032218300000259530241481142482901077895460011579600275028600000000000800000090000000000800000060003000000000000000600000800000090000000000400000000300000000000000000738903003300129180670001402000196010000060170002660007000000072100143224040140017000130230002500000800001000000000005000
SP314Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT512000148010400000801320054000339123000000000000153000013003202500000000026201323000001201400280003011385000000000000200000685001206600000000000850000000750013000561076000000000000143000000000190000000001190634000005106200700095880000000000000179000023008600000000000002360000000000000000000000000000000000000000000000001201458000000000000001133000000000000000001700000000000000850111400000009001400087100000000000024000040090500000000067025660000000000000003950000000000000000037002506000000
SP315Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Lancefieldella;parvula7361670400750652317415050262000303904399043801034091420323111841303802200060291023100298401252223140769996631006062204300243423756520600282171800831596293607255700826973201965018020840149411181143701688472613067019810279171263529932867180194532711701528197682141170381742570124783146760412087421540200325129105592821569373522907061750141215694095597304510212624733838104076620490106401251995320179632228625614692423478033246167383633323067514669720539816962169192580123234611919626075953952849451824221051157514672503561000189135531613421262331195155810901318975565811922806693722677893671560155824691658172436734208394817202236796032781732573835713145014138413250818766217496361235199154603117624438234317742501421209148353013891601039146816861949219225634440030512771774192291121701738666183435947151681184157550191037210781663811374532651896567208611353421581364648386152591801383277534115634062901421104155213346038034314110645144016001601182129632716891514649246264250531224440230541882002092825420221163866323117268313728211683072667301159459295923100749341689
SP316Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT0610001300000500472372000000900006000034046100650000322323400000000000090000050072000000000000000325338845020005900382200000000000000000000201120000000000400009503820039000075114800000000000000000000053000000000000000310282113070001305013000000220920597137102600591420667163876158382018724181172000112544024307102216113123396025307600682589387963736704859024085110132165018700828150126161240779001517441104100884480012700155632265471166049041370491010193452535920032501402149008912700100161223210445427895908990283631215110002731606500587182449513401556280827176433181955780347102506600014870640056300283151803650001022811550006015052001196886236613290145210006233614275611996002500230
SP32Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;buccalis17300288700004447162239742351014800000784182690311280724080031600137804401123756598135259714740570004108502828394150900336400000327411290879000174100514111453307191312286214900351001170920270491233239592033771225664879000238820300125358001289000012336834410776507100000034539606140505198052700398000770206301168159224615100218700011782360191142977001330000544134345014800003540016164852810116857080153200441002747991175981716629123921449917610527000556456086108000000000000000000001000000260000000000369224130000017000386001300000008900000001700302460000050015023110141730008900370001390000500164501100003273080882400500000369491545213719610005350123643200126000000010310000005436002067150000023007710747901027635000941160074
SP320Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;tobetsuensis00000000000000000000000000000000005000000040000000000040000000000010000000000000400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009000000000000000002850030004300000117000000000241003500000574011178720000463135000590000003620024000277000015100000000034890132000005500131450200002662000015000000023005000331000015000000000017700290000011100144723100001115781000124000000410090005800004190000000003700340000016670864626000067823000138000
SP322Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;lecithinolyticum0000000000060114300000000400000080000011501901403700000000000000000003000700056000016600001000930006259001610000000000000000013300000490039870018500000000011001150003132704746004100000000000006822000007212003622014800003010120010150050400001670065316028000000000000000000009003000000000000400000004027008000000000000000000000000000000000000560000003000000000000000000000700000250024603700000004019002000610005400500000200000000070007034001505500002000001700000002023100160000000000
SP324Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;endodontalis79006282696140900108175001807333310068000000341001248058300012400441062700024100008342583440098519758640016945320516861763005540048002300654300191801176001483470010110368000283000012462111300081215671949002822001169411028001260000038166001782014700053200493072900012600005381679600221298013020002532124162236102410028000003430008790954017452778100201096602107000005543000005270000000000000000000000000006000000000000000000008617000700000000000000002200003060000009000000000000057464800130500220200014000008000000070800290630300000006000015390012222314308000000000250002603300014000000300000000
SP326Bacteria;Firmicutes;Clostridia;Eubacteriales;Peptostreptococcaceae;Peptoanaerobacter;[Eubacterium] yurii00000016604490000299000000097000400000004895503225000000290000072800004605360310271320257000000028820027180000001700220021200000009600070000002030275029000006030000600000054000120001050491138501472900000146092000726168000036108060010590640103000000224600061400000150439300168000000015800031113000000000003000000000000000000000900000000000000000000000000700000000000400000000000000000000000000000000023050400001100000002500015000000018000360000000000000000040580007000000000336000000000004100000000000000000
SP330Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii81021000000000015000000000000070256300450000040981029700000000232778489002460000091071001940705600102000000004249000029800005691154000024506000313825021558310400046170025840780412002170000000333136210180030786000016231132441700000100470223366523802769380120000527360017930150036970011140000000935456142770034834280000804191233340000341900053143640011000000000000000000000000720000060000150600000000000000000000000000000000000000000006000000300000060000011904000000060033000000000071421300522000041820000000000010000000000000000450020000000026090025170000031200000000010
SP334Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;paraphrophilus0000000000000677800000000000130000000019511344000000000000000000000000000036600000000000000000000247700000000000000000000000000000180000000000000000000000715520000000000000020000000000000020300000000000000000000420000000000000000000000000000000000000000003540000000030000000000000000000000000000002100000000000130000000065000000000000000000000000000001520000000000050300000000615490000000000000015000000000000011600000000000000000000322000000000000000
SP336Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-1];[Eubacterium]_infirmum225012020102000002931000270463000001100560160000100165321000180012700059002212601115005007900236019531001300130788038280000462519161000031540850249388028501660538002620012646603716901417901800701660150604231137029041552855530366557119045603302900302223643642501480411250083240463029156672614611619153524022911044916847040517217196880613771768036534611740000330000000000000000000050000000000000000000000000000320000000040000000000014000060000000070000000000040903361000000071003000400040047700603160001300340001120000270096269600130000406501201200054766301900620046000500600112600
SP338Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;forsythia388000200000000150119000000001800000000001703012660000790010400040600062000060303030080011000000002174702552044153572700010008450002630067950000048001032300155301860006000032897328021563560016510253060003330065100037800111211111500083122003426034018902040770060559016014631900012021146156159950001239003540002007500000000300040000000016000500050016001500000000000003000000000050080600000043020000300050040002000000500531532000070019003620470004051001709001714041440412700014600000500358413000000694342201070400081202107060705257043100070043000
SP34Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT48100022600005472000900080010000000000000001130084960002710718280000118005631336300239050800131000316203100001351900000018100444141603552212800007000144112900112370000200336705180010030490013000032024301150000130143400346004202840002045749002001672205258012000013717000000365075172720145532229000200000000000000000000000000000000000000000000000000000000000000000000300000000000000000000040000000000000015000000000000000000000000000000004001322003000000070017000005000003000000000000000000000000000000490000
SP341Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;cinerea00000000000000300000000000240000004001200000604051707866100000000000000000000000400740000000000022000610001100173000000000000000000000000002200000080014050000000000141187000000000000000000000005001000000000000800085060000290000000000000002300002700000005546000005100002100050001680010000000000000001070000000070015763000000000000000000012000300000000000000478024047639000110031160000628406173284003105011801955032133000000000000002060006821000300203700001000000075700240406050018
SP342Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT4750903000000000200000008600000000000000008119992335000196139000001611103750002900000129106000047027050000000000000272129853270001800000021058025300010000001800007173098000000000000000691509000008417000002497203160003360000038036800001150625082200000000000008319294400006843971330000561400000600000300030000000000070000000501000000400000330000050000060005040000000000000000000400000500000000140007300000137003011502909000001500000001845574000103600000153800000490000041100360001005100000260000003241700004900000000
SP345Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Bifidobacterium;dentium000000051300000000000029400000029000000000000000000000003500000002000013000000000300000012400000000000000000000010317045003400239002050000019000274500000896800005000000146500000000001231000000013570047000002500471529003246310150000004600000016347000000000175764070030000000000000000000701248000000000001100000013000005000000100000000000000025084000000500000110000006002450910035400002030000900004000120661000000000001800000017000804000430619000000050000000090891000008000001300000015002114
SP347Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT902000500026300000000000000011600800600000370007110460000006100000019000377000000000000000557002240049000066000866012900000000000002800047800000500000000037000240094000025000524044000000350000003300018700078026000000000278003100133000060007630400000001120000000000000000000000000000030000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000040000000000000000000000000001000070000000000000000005000000000000000000005000
SP349Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT44813501139000075158000000029913076309000270348456700590200690000000214555091630730000001630311280245038924020587006941000280671763619100003100125824900212633929349004000041461913103713003700013230163623015070025910595590010095002306225544949444301200411225159107222045794171220000135003463543816919511000380000297658301248977322016192400258174000833738042795131581930024310780501004727127479542000250001599228201477900000394000034050015000170000070000436001205000000001070150000001200501030200160000000074159070990000320000000094013000000140040311017074500352041020625654914038182912301618161100150000106271334001100021007403770000246300000061694405506855400015886009006018401900000011365
SP35Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum4996308216901337377401369120455553444860263590426612363205211850472717843121445943142915738777528093369340950841146942625453816013556698591803705132807320469012493704729871957977268251931338389456410103807918661776129201319912123153001734170874243990180315165182571171300440272692586595675202449031223527202845777189066221758893629074100122383718113161038191013049317389942574551426781487954057297145031923489134889597177435948432121734599187202772195021211068594189136272501454791102010531206652093684611590485754449114244016215309858139928469520047087560978719613514712931513218778866457081748251343797143057201114419572008549273150197150686415100192807272864101645416377810019154852444324737211597023687331545721089200919933534860724215084311629810599327221675429677022124475310642101081241116722778543038076050432145325706160583133793028309010317383281658735598434329911421433110291043569742054842423142662303021114642122083241426226921401079142046612371231304553727416141129032904011093497534743121532875601480048961205138703626350390317530361637372191021805168684369804037661170323847131149885196112112192408406624124010127736214113841215840404678926025398343162306531441880231129121822720254136632391731510363533428131118840112669292407028125261450272393146355786167859149372583719740725472616424611593852131675886033852752198305373563497230711054243
SP350Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT2929120000000000010300000000050000000000000001120000700000001154000000004450370005100004601300180421800000003400000000146000084800000000002612203404600130009027340000000011000245000003030000019030000000019802412100092002604426064120330480420000010184000022001880000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000120000000070015000170000501600000000000000000002000000039000000001500230001900004000000000050400000000000220000
SP353Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-7];[Eubacterium]_yurii_subsps._yurii_&_margaretiae000245702317577000214910000001101536000001369000002950287617417229868160013300308060393812007930654189400930211485009000344067340400470147224015019235056719481219167740411696406760355281400208806144658208505583000000570193400000003410340147126007174330169470425329139760197203086218620039101052376221001565020360080021835013142504012030696000026101731687455003391053019971320613010173700000000000000000000000000300000000000000000000000300070100000000000000000000090000000000000000000040000002730480000021500200002000700008590000021024600116110800905297001710360300001600000053073000100080000000450050130292028000
SP355Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT8961524001438491100042658000003447010180004440067000041400136738574250900267600192907002503000130200181750256822000055000037010909801911025014360016700088396204421249774460011226206411600321800059700220980881120000257000502788308900063301912200032324201010877273273129800162100601455001734000210900586413552880000155000150162230866072305190013800086062901451363291843110064650070121940052200000000000000000003005000000000000029000000000000000000007000000000300009000000900000009000800140023000000000041310000000008011002900011000000630141815101300140006000000300023472300000000120000130017000500001140121366000330080000000
SP358Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT21811000000000023000000000000000000000000000000000000000130000000000180000000000000000000000000000000090000003400000000004500000000000000000500000000000000000000084000000000039000000000000000000000000000000000000000970000000000202400000000000000000350000000000000011700000025450000000000236100000000000000000390000000000000079000000158000000000069190000000000000000074000000000000001080000001390000000000023810000000000000000023000000000000000000000
SP36Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT9140009900569001190008040000011800000300200890988050211000021114002510403000032100335000001416000006815370004200700397306013551000053132001180170000620056100000527400000470000081000002040134807550000103515800835501150000272002890012800712000000221660900661840062002570000723000016919043430157000031820018360095138000003004883021601430013623002001391469100353855530000210454801341080560000105550247130709158000000006231600030440527501050376035688990000264431880208149000000502001097007350602395002600372623017005600753180120471437647475522304002393289069100430160004270074003861090230001200171412200041002190023427601011468620000325272240428248000
SP361Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;histicola308900000200144208210360000004100003301870000090000090001310701400000400000008522030000003023000036510520000081007403000200015168326406002000131000159330000041800003018384000008056740860619090043900000900011104017801440000001511000039101714170000618002000801100120211004268808502033511301001035257150116112203750716087151579001440350194610003211191128181623328016603862000129814113366109417001813010021187453168224261447792020223014237034470010142271711059746911122869494813603003951810626816009515326341848023595466873407022092165764628191039052017713251348168501694570913240305010702029220071326000148039370041551451118063101381656233556360007641276828822355488782102335880224469837876097102801028042801092765015296842173236035701124514413002612208412483411130581700647364115011117239441652000291216216947114763430136388508025279563401580883603301672317141154538
SP363Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT2750000090004763749056000004010010000030702540075301643000000000137002210000258290042115137011000001802400304200002060000730044000000006943530000000038100085741005500000007640013960001950329008890220000000000103000000003354040079269207000000000140077450001300100130700570000000017264000000000120007000000000103000000000500110080000000000000000001000090300000000000000000000000000000000004000000000094000108003700000409000530004050048081180000000030000100000179000238000000006060001390000014001002100000000055726020
SP365Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Mogibacterium;diversum267083000036702400176115300071068762014000112303330399053172119316266010581332303612301710600119177395530986847948939551355435381688056092811432237963456139216544129510526878660560493345297147214200536314310074160232758240582483461042781312882601190685512534501449321907699104269145183436369262110330710902641814050124828092109605217419727331441512765189525767837322875215725232413422524300265256950278111262197334872656511931241446358459022041117723707492987060272419062997636419635092030232533172714193154585236186579513467825818743577461536013026512582743412331238411113810270674284604561286106317451001245622518222689013543459704686821326658739903061557706560842956769587241036398119492802574142891668779535796854145227121523601502551838664088746989469719132363717846199691025185380959118610732013893083958133328599586193133418916210718354172406932884692647121399714934171111572479802971722916075032242794730692832476429045830418729931041165021251171290386216153716721615153
SP37Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Scardovia;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
SP371Bacteria;Firmicutes;Clostridia;Eubacteriales;Lachnospiraceae;Butyrivibrio;sp. HMT4550030000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000500060000000000000000040000000000000000000000000000000000000000000000001570220000054233370001100002806000009160230002545002836300350018011011702316500018021616621400900004581471400007160194005143000185114017001301604230330190004822224295600260000419105373400002116707200057142120103676964402100670502280170600033115418735500610005738116361340000341028467078560003228336360088000
SP38Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;maculosa2230161248005314587900317836166003320431440011100150080017014405415140328429605877428373311505334342183145851183292265038044231581059209034517761013016926903409315619102588375691662438201021137337183272707612325804013533521377635710811161373164305213175517315337107623248933423826346543012013136372711388724684428911370584111604475163945062635867132523059119101211562072031123799184974459245636905830817560807011117687569424822064191703082033128137425278080359726247601694250000000000000000000000000150207000000000300000000000002000030000052080002000066000200500020266050000130003433103470005913161345078904000039294540182656197310100702502073208186161273007802510137011026050720003721649048041640202572902
SP380Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT3495703000055343450001244133374000073390000000002291000500045321955782186000000154014324252133703943448095901570496214842000000394103685660040610501171100366008382041915310408006703520814248332706461442281900717584922592801917399580130032748071270070006759306120101413080415842657334400160002779014145342126093814481192430327572557144232223117067907300212341008514008680308572241465016214250011812399872710590901502024000512116490000018002000000000000000000150300010000000000000000080000000000000000000003002070000001700000040000000021400043536400648651016300002616401300042194171400200013620831000000300111300245125031121100010800005752002000224406022120063001901000004301226
SP382Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Pseudoleptotrichia;goodfellowii23001200581000000000000010600000000177000000000079000410172768000004221700154700000000040002400000000150000000100020900047081799000001917002460000000000000500000000450000000000230003303202530002907617100140000000000000050000000080000000300102000195017417200000000000000000003000000000000000000000000000008000000000000000000000000000000000000000000000000006500000192200000000000070000000000000000000080014000003390000052700610000000005000600000000500000000007000004129000
SP387Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;meyeri00000000000000000000000711050008958000737220000021900000000158283480081000000000000000000011710002421810001021870011009500000000490000180490000000000000000023122800077431100012591113003950011300000250018724965900183025800000000000000000011078313271154460001321520002600339000000007315814040001440002008005883962900013440290000009280331500002153452031466030000322400007360060200052290041247514001120350230000590045015600072332397070022500001453000014850041015300156900447380300781707901144700001012819014601329686816758251011400004570005371430396136003238005813706003005305834100020393631050010120217400250817000011160000
SP388Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;paraphrohaemolyticus0000000370000000000300000000860000000110000000007000345039811300002760046100000080000490000000240000000040000000000000062400000430041000000000039900000001070000000000000000036001020182300000300097000000000024000000300000000000000000000000716000007500930000000000505000000014756000000000000000003800930663800002600110000000286000250000000695000000000000000004000033300000668005330000000000135680500003570410000000340005000009440053204345840000423002212000000604000266000000338105000000022001200000050003205290
SP39Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT41730907424165190181001556526246360011001412501630000000142390008020930001751001246965131457611133011270023887153101404255383101536807471460007969181645000220006354700502512580006424604900149951598267118591641233341014370231948010850101028518123820084100312905360020860000128259000000001237074002601033520990308235001024020961370112082239543110199101354762024372202739787106518000020758560217904900009900012499336720107681528283830119234576002234129284428279034262484300023602981368210013034545793670163755173099351931411043041417936611026212168253165904301893901628123979457603671480940143166024562286076738934836064763644770198323292470222972302997681630153681522143430232836443099201928095117446058528534009950915866024172358185150585535800127183725607572401212701226161142641024615104657108106915135368533881672605572026321011681589127917831901670212304038402619101268525142490253492472423533395717323331733604624100370003045064083671185108
SP390Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT2840005350004003912500650000000029300900583000006162037840000000063000070002450000000289191000000000000003909846000000375266456000010004300000001775005200162000170000000020005003540000042834112000040003600003800139600000017194000000000000001001405720000087157204000040001700000000000000040000000000000001102000000001000000000000000027000000000000000000000021000000000020000000000000500149000000610001400000000000410280000005230260000000017000090021900020033000000000000000507110000037710000000001300000
SP392Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;sp. HMT2041100790623231333185841967868128870586656090312538455123039901462025105976322501448523183918611521034100242624102252294043343435627100371227060356731709186275446364101220005940017902020533779823770645323272584107059141981994239583771224820225635605201002276412191113460003374817293654257378675152574658012493000200490862116576191669802812632829475095654917386173859348050110287178502790104363294135115849001187094902015581841266177533922257109001315357233920701611995080337292324710730111110203841101477242300154830612843702984322052940255707000146200614015123009000019050300166100010880140000304101000000014090005432060801127000003180200408258004274090019080117012003018860800013229490106112452027105059007178026260402329676106611018018535278175019960321722010143200083549029373415171512305000131013764015611811700793029119242494456106001418958756
SP395Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-9];[Eubacterium]_brachy98004003479611521660143360228001560036611311400186052950068410152262740842836208420841033406291320029383003973371712915407008692292611131400000465907530050105153195385884873297309010485635211917968101684128104361128126727316001348010607005481386282951493045016696642616026845411125645228322911626320781416501922111260272119163102308388250385925038027360217043260005711423730242614507806057806402012169500010203371069442544483323905412475105865712774611340200014005004911207003320000002210408000130061600217002004003003010003802770200170009004010800132800803000408041200900528010387005345118699472901521509662012308692382006835363116981528229166704020320357530645520291325169275483000106520493003185157265507201824182102013912470114072160901112
SP396Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis_subsp._dentisani_clade_398296600000008100856000027526081010000000000000000000000000000000454500000060004010000578129904480984120000000000110000000000000000061720000000000655000035003900170000000000600000000000000000458200000008009870000107910107401715000000000048000000000000000003000000001200000000005000000000000017600000000000000000690000000500406700017011010000000000001400000000000000000077000000024001800001900720580000000000770000000000000000044600000008001402600113201550621200000000004800000000000000000
SP399Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;oralis290031009100001596001281000024145700164312141656900000211104703147013494370000331802701500440327008200162000437100216000009991840081317396111600008653080370039602100508005107900001400470089000011650064200008247005854434241180000121591010274086238000091002490129001101390063008300004140011120000270400030716859230000092806240000600181030360000000000000003200270000030058055800000110801100000305038000020019003100002700000003110002438500000170000000000000000001300160000000900013708007232008654777700000851000361208005801390710090000137002380000440014000025170002158320000059015044080034000890000
SP4Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT892220371600101091437436001000035240062900060060000470305152067225600376028851830623462018281223003426561541709000367378281038745086220014020263860153300658362194193601905018013421001101002732610140500000353371970049035123008203401023604432150348870459121810344044021432662110034815306171000000206223129770101802660200230033098026660133322166152158940650732170000000000000000000000000000000000000000000000011000000000000000000000000000000000000000000000000000000006900470000000000000100000000000000000008309000037000110000000000000000007600000000000000000000000702312000
SP40Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;salivae2070100901080023400037414200403750210000370000412300000220030021789040250150003351500351003170397738600691742670000015507008667701900122000014133005744907900477112177038360033901116227314560858132291000000592057702611615900038230011001163820009704500138607603970032809018835140007081241526021090522741030026159715590115210070952470082910043010993038116165676553940947236123361087778043595801827455114225701382297918111671862319323840112833729923993183494306865304234320194830622517031338156634114520096182915990422931539375022214415494213546796833031810041964902118771874153195544581451853041411477058619024817324576720140649140165015877441126692203001312352106422491203263857115356420891414369224182177611037895195163763195435718585263869360728328782621753377547260439159251621409752051789969351888190268253553316211601439125297437852676221482896235912697038925122124246671720780260524222833610049792367110737135265446104832179163150
SP401Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Megasphaera;sp. HMT123400000000000000000002840000000000000003100000000000000190000000000000003009620000050002000005572003000096000009000000000650000073301019600000016408000000018580053000000000012000000007192000016001028517790001315038040860000014885001320000602000000000000000000000000000000010000000000000000000000000000000000000000000000000001100000000000000000000000000000000020000009004000000200000000050008000000000030000000000000001000600000080000000007000000000260000
SP41Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;dispar3152824011210252443241606608700031210226004386021138671440244252702383102899202601900199806605101856511600061000110522320002832172624251331415802931572236280425810570121318563300004896314431509303900122210439200033230334945000922132319811825309841003300006330111027010107413800004700018013181240016350780339849417249097507658002320338035001708396131425180011410646264767801539400540263960046532357477111563625168119079820784113853867338515222535185103602316695347318382714102725457723691937972554284845440302774718836337461319196623839336131993638350158624751030231621240331125889951823865437364985251616223852191984463113851031145447400716172122186447996527441384424164911867340187417375054879813653914057550424973560981277284532660206822173140984110121823907312801912130903684109116601920992485115512008963433205773832352801289219113021363641498767877860317645511506933041015402411569241396982045735513691496135068983485683223179149910238616825845219444468225068771857
SP414Bacteria;Firmicutes;Mollicutes;Mycoplasmatales;Mycoplasmataceae;Mycoplasma;salivarium70050000000004190070386000301800430200013603068000000900034005400057070100043000907860040234901213143100010804021000002800236012077002800000503230034690082911201164202607123014100552300130101600000040011049005000050649200962900039015815400007523140251502080018309107901319000748130396266900000000000000414000000000007000000000000000000000000000000000430305000000000003700000000000000000600400000002000013150200190120370000024116000064300009600340010000400000040140090700001200000411612000000300004000660032000
SP42Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;parvula117915857811675759886353410317685808985223732794126148710732631169119236932253216723375313279061542148969992214170215997734925583735211309669817352927931782569153135040941837112688538837917097270941798480964642470881347831933350893156995676489817826358317910125110562144125234931287201202515698243676175026717813042756518921278653101601251490412445824212178919727687983631714318116652585454576226181204745840356705675079122442745960300664847661689676827301171493893210160212128615159182638518201060110495353946431278571029118232413481210255113731614056824125242518760396214597237503153003514052623404661828333147318624665932032052166049254519310764009203780322195373001117547637263100955736923869291590259572721682612684252187817821186800153719102886085014481507121425310748731461133128722319103619129001717296276178060913102123179645457555561842535361000103480123492006161168473761604214832819854898034080172313033585268732351167423153316282315447030717518524091787961105538105221012394739873112782892289611202278144063439360151960016911891141227710333342027135215675258126101063101176125906780531449185998820737525822176017916131519837745775021901394100163444232951816228551067107524637321746434105355358928298405011111205134220839522097025257861523266506766941385
SP421Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;micans5006600880000001526000000000000004000008204312806312300000072700100001207001410000880324170537041070806380000116293000000131017800100000009700014008320054500000455252070038070910000212122000731020286200051000000713046411002830045000062711065133135058220199093405438657200782323000357302529200710000001939030000000000000020000000000000020000100000030000000000000050000000000000000000000200000000000300000000000000003500000009810100700004003000030009001327001400000080021000470000000000800001005700007000000600014400600000025000
SP425Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;sicca0000000000355000002400585000018251763000000710000000012493144000322000119200000000000479000001300000001164527810000012519300009900046433914002600004720000000000024000002520020403000013339500000136920000360000174461600109000180000000000068800000000000001200272800000017700001980002641637008400020900000000000500000060027000001200000044000025000661500113000370000000000023600000000000000380000003100002200051160061000610110000000001740000033001295000013137000000840000456000348288001224000179000000000001318000000000000008510000072101000013200017538000216000940
SP426Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT9200000002526120500000083000600935000004580810085037302200010010018216000100013301608013673002006915237004002050160006002292500120000007919302140203207531494069004932811114621051891530000012807400750016511707050100210250000065123342440112000074007742019421118211107021620655109054031116041032124904000148171600010000000100000000000000000000000130000000000000000000000000000000000000000000000000000000000000006000000270001201000017721140000050501100002501002000003000000000002000000300000010000600028050150000500000003600
SP429Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;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
SP43Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;atypica150130880010053013310000150060004100484903603700000034110015500680000051430034110000007012000264102000280071761901793848021201902000003240098003300027028272528082100560266054900155039000010037002767028144500000004864047009213000039320004000120020565180043740251601130014375048422770770210200000261230000000013002526153064448155419200476490085953531011643452721421358119916328164603554319633191195820112373238170478845246682538710518482690190471577211356142572039171420242053826792300115857858536973944790222813302522723968870264807391883112473739337834074224642639011576048342483806151769248031284563940105151058003720101502104181106486689011452537411432455335983728617717531569010011708193130051489105774546842140665210732001949101616622295232313239019580450366380405539306131999781381347103103416526917334671474961122523777753356113305657864423632819574630010328837683435557475246389359412417456720038221282702111011283581236126154433956098154615002745786233122290705617474619848308986972911185278136112816433257
SP432Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Parascardovia;denticolens00000000000000000000000000037910000000000000000000000000000000000000090000000000027600000000000000000000000000000000011200005000000019000420000000100000000000000000000000000030000960000000000045320000000000000000000000007000000000000000000000400031000002000000000000000000000000000000000050000030000000000000000000000000000400500000000000000000711000610000000200000000000000001700000000003000000000700007700000000000000000000000
SP435Bacteria;Actinobacteria;Actinobacteria;Propionibacteriales;Propionibacteriaceae;Arachnia;rubra000650139989100000015861643000007910002797980136301800728630503010000000000000200041306181344000000158802220000064000233844200140994000134109000110006078000000150782585000000801860000015330001201500011703490039378901000000000000000001610602304000000130103000000000814340014000086323890000000000068000000000000000000800000200001300303003006000000000000000060300000000050000000060190040000032000000000008000000130500000040160220000007000141500705001715202700000000050000002907416000000006000001100018800006000870160000000005000
SP44Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;serpentiformis0000250000691813211212033600000115000000011600000045800006870673000047200719850000000012152120520900000028205217000015400000079600005340220079200191430000110000936331001285012290000040006825600053000000120000013403060036021387732000000001251520199430390000020704612000024000000110000041204701200296160000550000019700120120000410000000160000082094770000000002300200004790000034706000000021980000001400000001031600000000034000000023300000360014081000026110100014005880000132012436000040000070003400002310000020050021000035083000000000000110232510000100180045000
SP442Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;goodfellowii670000078937000003981000002100013863600000013000293246160000000123067003960127000002237000002667740210018170000443121850000027000824655700000001150440000000000334760000262330460043336000107747646000005800979826140000000113013100800780000020721000064637039001425400055448300000124600424972320000000754083000000000000000001300000500060000000000006000000000600000000000300000003000000000030000000070000000000300000000001080000766030004200012020200000001029260000000801300000000005410000010006000150000046000000003161115000000300210000
SP445Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT0740002030000000000800000000081900917213301300160000000423000000000197000000000000000011025244009704706300000040003000005000012850000100001304004000030003003080110050000000801100060008800000000000000000092240061906607200000060002100003807870092211237000439132603935311060204302244064256361621204669410425428006220179472940906737003530125510477300283148774100346212720000393143780001512484099467910900003066424445011693773426620703503827916109161400400100710000944106001535253745505331258485008611014000423759033517961162103160593111317392167861625667005195062615808021960047704172344020014437349005113006700158632000001216900247590000011541225261087150410221060067538784630008250040300087671507227116900638945
SP446Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT223403001200000000030900085100000000000660600630700100004320000002960024500000000017390017163700001690100042727046110057001000000000000001220030000000000215900233902036000070017200018252656208001880131240900003500260002660055800000000013420071185688000015702980055131210663601317304816700000832700214000000000000000016000000000000000000000000000000000000000050000000005000300000000000500000007000007170000000001200000000049002804700008070026060000008000000000600070040000000002000135000000013000050001400100000000000000
SP447Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;bacilliformis00002499002990137890755500001219000000001303790000000025300033600000000000026804035404576318884415000071330000000103001002000000003400001027000000000000138063090321233086823900091100000000002900000000178000390000000000002550621059042373614291350000280000000182708890000000018800011410000000000001400000003000000000000085200000000001000000000000000013002500000000030000000067000000000000000000000000000038001000285935000500000000107201600000000100000000000000002502490027140000001640000000233206000000007000800000000
SP45Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;sp. HMT28627900175703213181539001592374249223306880650286800056000066395828103763412413132431670140146568267191926900024700343736546123125833003056047823961748571140545175324131308700093124365235605839313014606310761630571649299092902920790012636214145922827100365620163837176539146795114122900262950520402091924191057104050428916650029856421623700024000792191161642357747007659087513085399741708474361210273541000120312148158412500724730218302743900235626441869600162000019000000015014000001100000070030000020500005005006000000001593800000000000019000000000000002012600005003508000000062055308001374700320329150000000001100009501180266000813000000093100210120000180150000968000000196002506310800321300000190000
SP450Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;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
SP455Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Alloscardovia;omnicolens0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002000300800000000000000000000007000000000000000000000000000000000000000000000000000030000000000000000001340002100031340789000016350270000371800003222106600000257820300040000638415000410062134071400084826804041800010960000517102600001361120393000000078982340002070023450236500061784902233000403000010517705670000092159023100200000481660100056001018002018000153631056819000390000365504730000108140132200000006117
SP458Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;intermedius64029018200793253325260403072241184018237906586512771060293510481181630217143610966816346028681570947260501025920081903498530713460152513159549463011218260294410149382897431956156211634851696711395419287289333277112633377455304351560913334702891931013111148208192000109246304344454407893601079193467564415435216407071657151712041821103914333119168125748747328066534332247053723020525600137352537616720183059608954291646517486210730524694256453326376220037121269111684891761966116915571959834114748621555168069995252668501128010367730302107601150714001302211292403031609315010010713177000110022000050001500466067918017231103818731081703701460072050210000410015021120605054364021685026432355160171551100971764957551467861741508433765273012114832271615101130724602320360018989370270650201838074228147930437112415801947475026811241471130202732292972434270396003512237087313
SP46Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;infelix14800101536471704304001121055334110340022490953470000152828343001009619947303292008612320697151102737844200435709558159006391473342249214825902643450735387632300882522476151522187484436732012311022554126011913670841800180744141307240270108202519395332650411490363609144128623907701028030687295292729348326022036100133714016522421514553454606137208674331162343741141012103119211580237500661248781956263841357128030080145315722023733898143963240510202458879949687476080004020000121000000000000000000000600000000000000000000090000004100000060000000024000000000000000000000110040019747000011340488086012060050000241200500000050001014400023500620404203140341000000240000300016604000180414800001505200
SP461Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;sp. HMT8770000000706660000000001070000006360086000600017600062000073000769400000001903210000000002280000002895001030003900356700039600002960001921630000000160330000000000180000000204009500023300688000730000361000255480000000260126000000000137000000108800230001100026800077000037300059728000000000000000000000000004900000000000000000000000000000000080000000000000000144000000300300000000000003000000000000002000016000000230010000005000000000000000000000001200000000012000000360000002001300060000000000
SP464Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;peroris00000000000000000000000000000000000000000000000000000000000000400000000000000000000000000000060000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000000000000000000000000009200020000000000019670000000000138000397000000000000000000000000180000000000153100000000002500053300000000000000000000870003300000000001174000000000015600024600000000000000000000000023000000000045400000000003200040400000000
SP465Bacteria;Actinobacteria;Coriobacteriia;Eggerthellales;Eggerthellaceae;Cryptobacterium;curtum00000005670000000000000000000001800200000060283000000004000000398002300002600140000012003122659000200800002418003000013130004003580018690021472540031006954680140027000500500661407051404012737400000099100462100375248486002500186821703356312190211270001680248140118004753004135295600000000008000000300000028206403100000000010017000030000220000000003000000103000000041010500246020600000407700004085490004000005108000018000000080211206002070050090820000000001610000005062003096700060000461131870238002007523800002603004
SP469Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oralis295241900000000005940000000000004404300003300000000000073000286000000530070027402240100000052010961056000870000040000003000833411350007000290001532530913401300000040322295630960001223000001800000001960004070435003701930153900281340151276019700002700181412128511260000150170002910000008520000000000000000000000000000015965000002000000000000000000000000000000000300000000162000000000000000000000000602000140000000209020311100000002714527050014700000220000001200026000050000000090337013000000383623300068010001000000016000
SP47Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;maltophilum330075000043000023800010019000020000189000032052782101300000005300034001510287000001304070002401002450770000247723000220571951195300000089000910041406002680000367000400170000340002606616500011600383001460000003560005805268039000000190081001429802370510006651001991363560014330940122012000000027500000000000000000000000000200002000000000000000000000000000000000000002000000000000000000000000000000000000000370000090000000000000000406000000402000000000000007090000000300040706000000800020000810000000000000
SP472Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Peptidiphaga;gingivicola1350016545710110000272203227080841490325510201676302300148188367005200443011611401638443237006600713695003360239533600001509035901083579634037002855185360031229803740103509209743323037519496001330005118004206423333000143401229086482800752018096511010610446629419731114520252820252828661142154210044000091950079004513000017150110140163132401345002211919601372561560550962021500236131973000954000800030060000808090000000090140000000000000070000700040005001600002600000003000000000780000500000505000000210005130160000590650401940200002050013200002000014141625130042001410140035002550000190190053070000000002710040013000461706007500026
SP48Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;artemidis00027284001121040020580011600006361215402000020803486895645505649819738002991585215374018217764500712731850109017217010127100172004050592451664890002948807160717890272812618643240631387263027815343210051737150626101030111752003920011502741301144546802018198545534802827184272183170020620894413010057896109001318512201144119609493000620011503932073701221882400053160051539105653493174031741510014721542800274124200000000000000000000003000320003000000030000000000000000000000000000000000000000000000000000000000000000001500000000003000004100100000012300000000211000800110031116004030500002700000200000000008750003000830002010033
SP481Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT8693690000018007331420000000000002120000000400000000600800050000120014001900341610000142000000010000000000040000000000025000069500000426006173900003160000000117000000021002600000230210000000079007400261200116113600001810000000001020000033000000003103500059000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000040000000080000011000000000000000000000000004000000005001200000074000500000000000000000000000000000000000
SP486Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT3130000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001820000000008600000000012800005700000223000000000011000000003200000000002590000000001758000041000002280000830000015000000003980003000003900000000010908200010000002910000980000029000000004430000000002700000000015145300016000002640000267000004500000000
SP49Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT332000014231480014600182000000003212600000000000000913757130274900226056100230050262000062513724000003614570000000248002258000000000005740146400510034300501900000923768003900400000000051749100200000000003720349046600229030900460038000052159270000022413050000000051700125520000000000052708700163502300005202000047007000000000004000000000000000500800000006007000048000000000000000500000000000000000000000000000000008419800109048000000003013000160000000006104001000230000740021800002639700000613000000022710052000000000008100440078000011003
SP495Bacteria;Gracilibacteria_(GN02);Gracilibacteria_(GN02)_[C-1];Gracilibacteria_(GN02)_[O-1];Gracilibacteria_(GN02)_[F-1];Gracilibacteria_(GN02)_[G-1];bacterium HMT8710001349000073000014110000000000000007500000000000741716000000344720002960000480090112003100000000000013600000026000060206500000025500002240000145001601009000000000000000120000026000000057200000028455000430000000530520000000000000001220000240460000318167200000023600000000000000160000000000000000000000000000000000020000000000000000000000000000000000000000000000000000200177000039000022700000000000000000000001100008430000000000023000050000000500000000000000000000000005300000000
SP50Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT1707428591030918021614626118214114757991985118291516505231733837596033522081333100332943433441348215628783742153887811015011326738489863111712273395819552586326832027734972029859631325751954453318525631582304107811704711308169815980398451224850690867102207623298209618681593425461423671829128117074197381281797526299891177952822506477032352779310935147234517523977483731970022100323866907625983358231752075942145253548444497892994148904251248031933063013711399521159640289211574131677929040535130532258327915616611480667646202760135089103914544620605568234426233810791468456882368905041573671673322156710121316143513811736029111417030687402900730032339002910000171500012000537000107520632050044101001100259106800742002013627151529000497000001405365001923861503330005155104501190212342735194020046354069208252830438111601750129180114797144170030221026418742430211950102113139182743899368193870158232316315985373108921625101417128560835006956026158484350161596311358501031920622309308418444
SP502Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT277400043300000000000000000000000003000000000002076000000000000024410000000000000000000000000350000002000092600000000001910097300000000000000000000000000000000000024170000000000000132300000000000000000000000007920000000000631000000000000000000000000000000000000000000000000002900000000000002700000000000000000000000000000000000016000000000000013400000000000033002000000000000000000001380000000000000190000000000000000000000000000000000000930000000000
SP508Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;massiliensis00178000000000000000000000000001124000000002763000000000000007000000000000000020000000001530002600008850000000000000012620000000000000000900000000065000450000369800000000000000654000000000000000048900000000049000218000046930000000000000000000000000000000000000001010000010000000000000000000000000000000000000300000000000000000000000000000000019000000000000000010000000022501300012900018000000000000006000000000000000046000000098050001800009000000000000
SP51Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT336668032630147605501998112830325098047013470596202070810027379494259119069254042034003563355320054262901227301362032950274206546642845015702240133001101776200310122001532475135637600854020047003813226109052317001722845802339086702641391822345045307510400427191620115022502910073152322213224029960103087005056076030109870168147824606337016640803042779309602000150131186181120521179001191145473725805278011034004563047004772201036500000000500000200000000030030000000000000000270010000500180000030000015000000200000015600000000000073000000070232078004500607201000280000000000310003806000005200170003890290120101222007079012042701402000000139003009000007100260000
SP52Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;vespertina200000014000000000000000000000160000000000014000000000300000000000000000000000000000140000000000000000000000070000140000000000000000000009000000000007000000000230000007000000000000000000000090000000000000000000007700033400041030394000004000116100000353927800000013052701541000000081001620004290001410302325225000015600023331000001468116612000006209310718000000012620180000841000128000414000227000171004000004390292700000007960637900000003300181000473000324060280420800003400049134900000111051241000009207550276500000004590
SP520Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Olsenella;uli63700000000000000000000000000000000001100000000000110045700000000000000000000000000074060000012015009000017900001195008000000085000001927091130000011154543094000027029310144000060213006322770111403480000380000029263010116600059133313256023700004801230012600001506029006390000000000000000700000000013190000030000000000000000000000000000000007000000000176000500000000000000000000000602100004780000100000000302528301400830011049600040500000030120000600000000150000003428000000000000790000010000
SP536Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-8];bacterium HMT9550000008100000000000058000000000000094700378146807200000001750260000002951370000410000700261000004720000000690077193901600000004010125000000115720000000000008500000000000003467004334101800000031342034000000091520000006750000000395000006080000000723300121254070000000841084000000003000030000000000000000000005000402000000100000000000000000000000000000000000000000000000000000000000001613000000000000430000000000000000761000000009000000000211400000000000037000007000000000009000000001318000
SP537Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sinensis0000000000000000000000000000000000000000000000000000000000000079600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000672800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000150000000000000000000000000000000000000000000000000026000000000000000000000000000000000000000
SP54Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Bergeyella;sp. HMT9001190094290010771810409554323703700055875306731046094003430461901610346565523172173754539572100828656023253432500718843014772813755932582081013700322383463302864589135001767562536000182439832181155192143153342724002441763520613571002818964016224991511790625483483009829442341320810001972173174040303901491095636522833948567722558027283174008892208902373474631722561064904925815392226838776130026350652720148522599710211527328822245641996070892106180000000000050400000000000090060000014050050030002600000000000000000000000300000130005000040200020000012252000089514001650904623310001130080032300770000392772509065140058059640026060601031300040003603800301000504005100013585720040482400
SP55Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;periodonticum6415395880234812660164711764487206238313571525271048253441450205093001121520204903565615384202023140057911701140143840213013045762203738471315437277019562094534176592813514019137642777089636615016222088967401921128160530535020189450015614519892129445511000611822130535171090028352067894857762616022023371249321152020000181032113421121333670984214200564033394729280677160615901152427223844301832662418775815815793930331370713352664273008810325547325221666127364424301195140201272171133171801699430204309125373333359359184124777713781946971573821694494542313386039823469816449982064451529412703984319535199497108841643010664677473270126113555061730907139813779891869612455794972069272891323912357552167131379136771194577787187439781749001996456043872631078493917638839129405704217160130043692452780064608880528903073763881872423620701550393015808025225363912425612201593272140216717111390108335726451535425686850560272291547173566933034864892123436185023813482755512125552813710438768723471164341622112914344627048222823731103049672440784901393116539351013192992768201866143829075248374985451175096926033724206311103331787280611601099163140735731921302707037254397607404452494147270790211049143336106010253939
SP56Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT4720000013888024080002313000001011740050913400009700375045415441118791111970210007105180488014200000067819101173503067730000005010076613800171001900320017329524261672222080014028117540858075210000014488702869485870933000002584200135356805950013800654060410802527822901280020080142701020012600000050314250138940464286400000249300403730792006100640134147045940009100384301194098169145000000013200000500000000040000010000180070000000000000000000000000000000004000000008000000000000001000080000000062124286006300040257900231300009400002200873700001502616019000000005934511000650000004300330036001080060009221000160001930572100
SP560Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-2];bacterium HMT35057000000000000000000000000000000000000240030000000000107574950000000000190000000000000092062000000001220014700000000722472870000000000000001400000000080221000006810047000140800000000511143585000027000001076000010000000000147073700000000776001241000000008352170000000000000000000000000070600002000000140000000000000000000000000000000000003200000070000006100000000010000007900000200006000000000140230000110000008500000000312100000350000000000000000000011070000121100500400000000026
SP57Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT1370015402803150009802411500141377132003946259001002460713100020301484020465742423623860612122114016314010072944028800000427503557247420300512064001100544010115100104285220603282535218287119282141402349713016049137920004201694620660212692670003028870070341005800512208871065116414430179481796337083525001313902170000053176042533146435005318111702198015303526500340512745408385112954428181308122404226800500000000000000000000000600000000000000000007000000600000000000180000000000038000000000000003000000000001431725000000100018104000501003002009000000000000120012170000900154100000000075016004012000090000000000000011007000000
SP58Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Megasphaera;micronuciformis00714700064006019700303600210001100003902700003200202600220006204112001900060032984400191000032201070000191878090024200012000151700164051449431015000170402091861191827922090073140546140001864107360110014130195306221270023101101610225120250145011502811027817210461131440440503485113380027183321476445100087029245002906300184201019278658210039900480791091288400615602794541969861155863042886266454237970010228153192864969206066855931581614433891051512551051800162414733185027551064491110603296322727830350215701230392452941292264228810942363161313300815590201227531938704545326773129448134843322659711768234021102601115993724601291216124138738628228799997044454425141325918814255805072551232400024126471237715306461003709273218711549117663966452098614704511472153125771735764111017039439411755711705443670887195381588816792297714032901100473228436347182935511313438117134465421233092081111055652495435525
SP585Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Bifidobacterium;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
SP587Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;argentoratense00000000800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000990200000000000000000000000000000000000000000000000000255800000000000000000000000000000000000000000000000000403000000002200000000000000000000000000000000000170000001420000000000000000000000000000000000000000000
SP59Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis_subsp._tigurinus_clade_07000270251774892978000018441008700000002960154000000070267110360000000000000005032939123887000040019830013080000000513098760700017800133144100000000003000019086153391366300034080800298003400002320444860000090047527000000000000000280348901425780000822332700331400000002660336810600079400152340000000000000000030788000000280131900019900031330134500000600040000090000000000003628210000010310060000566000140642437000002700018000036000000000000109802461500082695008900014600067011637000000233089420000170050000000002023564791600021742610042800629200021021560100000190013146000022000100000
SP6Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;cristatus_clade_5781953063175915337885580753666222236095211241368284381395248426032593746244087073309527503353845621296446552423331456100146327491082243461021161428414746623524541289153643190019782155175249621091114116063453076421137761123575054241572201990012645940266849091482392086826526129115819474394276265627027620924193860253325351617182945687178157698238100127721483996182839826252262135502284024962434616975633154326393257520013111402246037561789377542806397551514854974092884823703903051681835981631884599380444198306113861913352003130651818048394452742211865462941681227069133916901375223012594937601778158915001359411188448334901022136360232300141388314430439260468611583973200022153972311405922171153117812117431131111717209003041206491561214263278171171801162132114181514046510076368237368133201043411125255521471394323102334694222007476562612028938242127921015929373295138382031720152581699431767214583451696972326547316811498332116621853047668485200075170295371022651803525252961270485507402444004743505445918545652601577327311364191544483994741866061821733656118564120214537612493847954108050120389227127182351591161339165112468142249112461478420119348
SP60Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis34335715557081634711501048232197930745779573105892523752007383460305710435151253148485767574336641935791403506341347339411870647514155459840867924252323002693467300238119083034473666106999782311781104711381015820274291961154601558862836014355416720663960062147181426967031576116219437621149276481410023536873207821297264259021293930157549620126362497074379313091154960319304006469044048266304333594113713502112212008531436833475112415774738119365553126091171271082229957659352929783881366056257244327575292262183715746026583943289243887743438152046721847183163833302116610311728566344422947752782785640198044732829183614614435330125917942762741110211840622179479741029636437723812707356960477934046341439899799962309772890923876172344673992130509413244134305168101395411810212797131371806165526228661193274284414571314511510192248325131638304852813434910107918117456836413184117232805012529393544481061298919186381173771780215160135117523417302506412831514246711681510440210040641194257026202676911296893418655785243391444523125321083324945573452130192565292271141385228149610011059135419112912742883468118547521913439212184030158381187257200763953350548125499689743156191300287757543235812122704546501806244469553619223138808981478295685286321124423250446290350067017054591339
SP61Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT414000000000000000091076018001674000000000000095000015230000000000000001650000000000561164704500066480000000000000334200024327000000000000000000000000028563597000099340000000000000182000742100000000000000070000000000059975435031002007800000000000001340006316600046000000000000000000000000000000000000000000000100000000000000003000000000070000000000000000000000012170000000000000063000000000035301000420000000000000700068000000000000000440000000000176018009000000000000020009619000000000
SP63Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;sp. HMT8084130000000250000492300820281340010390300020000008770046107000150021900272610020400000180061160006025191150251000044069617600031260015130000000150223680030000606101200204185023230025361001137510761470316139157414001951129036089420000240035603544165400546012011170101001003641280814884577589264047892805264083738910112742480107493027040255900000354111014000000000207003000000000007000000000000000000000000000000000000000000000003002200000000000030200000000000011020000009701600009000107013051004060120706480000000009000100460000106150080140460002115017000000000001900000005620
SP64Bacteria;Firmicutes;Clostridia;Eubacteriales;Lachnospiraceae;Lachnospiraceae_[G-3];bacterium HMT1002790016204653747705905923752901362484219162077014071362540602190000153607020191029225942425750567811152917348165622819250369192114202302524940211032022419543359570134000255802869958193407764686800149327019632611550491712935012765441394531876255616387348513300208370745018500385165130012735327552767883180131178645902742185500021780011230124816138510417350215436072598301973211586071930451015989010816395856047747278968145900462901294550352402241842092005404430183936718731843342898010323278478100118358403468289070000006800013630570400032004098009100500962290400000360000136000600018014570003373000000093600073001750000161560384000000000131042030081157065095721402003648006471903016400530010030848861112206304240051111830023000152489000622627005000641073020290031008719323061090023017000241119400
SP65Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oris137102284521065048485130028701474300010530287963227624020825031870222810518637002464157284672625811572396031606036727600192828143120729414100664251304318964126933179134308304909282977440512179103610706563594125367158821297523284033569306740545939149812420683226101124731086153401422333282119436205563252311842401165404261721236427131885811613759765826053272821231856526788343775191007309180192016844390220751942332928434032202381173057183991962229344312865180816662321716522809340790307915704709927516563517844588960586196835771615251938606343623311129381909113553545692705125846310265151811572163281791202620221324000065172012540123309100084586435814111002851001314123638050154138010161734189000215925380600132407170901222017731366017500001213031210013017810268423074579209199223002442299936101293641315661776454851364810534311028671518665390228221669110211859830142811652388256662221683571128013913612451957048396053446381616913521033011435311819395033801945415020801741632553169321894217476529525765013107
SP66Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sputigena44602160212366064196352810267274111384322367022070600094653506905325540848189291169264417321277904187036947163309336442734224490192478073195928005441429100312309061221251410396071446144577422051359807265639144350283151190126623641802227322795026401605341747995321854574141749127609207724980629744130758183446630464461316939533486628947010758528315358256766155025674099377102702011715236002624278642751149211661126528106939516331770373310701002159731155276925447551520692105375472515003326240428830511033171163253633146639523652519639101375717071222762108004300007000020000000000279080000030006400000900601003555005076000034002000006900003020000000900020007084083348455803320202681632119754626060584281918365716602700024531540131396020041024474712706855207400628575819250000141147212801359104180201558410501188070
SP67Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Bergeyella;sp. HMT322527617835044454748232558776511623581356194634318901006187556572748933244462361815758134416286229154191274770812713225311298325113919617344202571430789267952529144527417084287966822858477746519239217333792244436433355209312368741767182667371085934310834923163511869043022092361631630219281561201459440215242669531944136021812367460567492361353198230442244694472384112817982454744292152221054113286916770336605179012406796774120573674126389073722152821474946209210902226257464744171459314679483350525362505283521717412749193646066426913161446471723817959108691117442709185661510525527391458775618843878333741841328529425418729470272624515912915868615175255249808392351414224271311461756112963122733853250125327331668635733650354154310634153642512701371142514425174309241083162281282148175261199024210571323020220202193248062290409720720437642716601285166114927147220729140129724514039947350318445227794618424594131537674206335314345121410320406613185686524021318622537848256236162342181957214288436240128451021492312772270357110173815527131246302618681021615863003010223365130308133731314963756586418304214192
SP68Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;parasanguinis_clade_411534210000014300950310000218600012009700184410730844690000662824009632300506025044016229001552904040049016901493440400204540029110172720811682690000861024100243928005210325555320113001311104880000371974013000135800136890159234943311000031626466144233013113015910180160081700105120277380870260351812400011255800161350643067442540000128719260019034002252601140187632476419423010214862633539987535920410685256233118331297918011132834611559771937461372040060130521531287092716849814007845003597019378107071218270065783239858151117811484019188501468425564592541182251937801648529981751808909451361265761663167162973198119001116301024819316105089078387861191902238163553661566316142121936035525011272429111784753373145969231518517512101318158591085599272900130907010040794240353352591328623389496130234494115766271139414083930477811032828015473293104432603518974874685033140813447473258319834361609371811374463082502046414018251488294959364880040756685261435227919811656515552270213690257856177112124736401327902180101204515748967339178032893711091705672195546803506301616721385648529650544323434807
SP69Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT300618018230000513000035040000396001560228009039830000782805920928731792106299056838402340006470679207323053201550642983693200350287312090040816474232006811900739723167588563133101102480058620014290329383413281375348140204771003391863599886432037071639761341931644722632170430386411901718329124602658960717701127330969829322722316923132932038155245429873895160219198652633120902067400168253435957212774769199708422556328110428100404000000300405800000000150007008000000140000000000005000000404000032400000400153000800500000065040000000306563146000015184900045830010260029305672903230102744613590043004700316384153108060963000282300017000770157032051204212107351404002681760
SP7Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;lingnae_[Not_Validly_Published]00000000000050050300000180000000170000000000000000000000000000000000000000008000000000120000000000000050000000000001600009000000413000000020000000000000000000000000005901001900100000000000000200230280000400000000000016151080106612826184865157031061928176110301016870111341823924210127980117131006163838751106111200638319569018937703608346445697328301620911929136349444603771403115151470963977892767322654972784481009134944352521851799233895069439135962455227542421291271601166212681301606563795161711558423217409240575146529762801078106110978707131457129158310339584849442643253016103957136220161046499463511792583197577232229921982180746819477721640026511015221450911101533017449316582931735892333610722311517772022332837652909511761661822413595232351720152218494379126205171444324414110665602215512715800126121733464613526284745921272481098124229695370221344354592290320449230
SP70Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;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
SP71Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;jejuni003800001600000000000000000000001109000000000029000000000003300000006000000000000006400802004000000001900000000001410000340001000000000000090000901900000000006000000000034700002300014000010000000080192000000300000000692000000006533715233939400552943202008430742351652010995490049412232822981410065163830147493892270653184083104705084313149505284201188125780954105796120100391163071813024189245158108630005350347922616942501160411875339663816930303838541526732922448241360134437019181130103724763076123790198051260991088421651562304018797090032011691812898151400017927881878850258812340104990402461826232306152609460538140106658211216397613517540440037908398442637145180801338004472515233511943023580392303185892311376960779121203568093116440111020011004161454
SP72Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Anaeroglobus;geminatus00449000200000001700000000000000003610000000001071130000000001690000000000770043000000000000000423113670000000018900000014014113002445000000081800410016000002742001626634362615402308100003025361000000600188100676330471100119369107017200320040000110080355240375012470000001232466000000620147393000004000023200000000000000094000030000003100000000005000000000000000000000000008100000000000013400000000000029303200076840500130080000001613504000265000011560000004002100000632000000000300000000016590040570000016926000008040
SP73Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;saccharolytica78004310039302222371345487439125004605822890221501602300730138033112650338656220213482039668950034117801158752220023901009332003219417848453210216971001274203704806383512360019307308617000898410748901266165281121190382790261686014084901349330236430129258659394896402163727831148036654312491470017332720603330071191455315628401751494101672059294187146008501032747007721176249967229814222441675976830730742642732502411984186900855109981676553030402433509384040564541051525000006000000013000000000000130000000300000000000000000000044003000004000000000018000000000000000000000000000520510000071178037110035709504406400080120240014040300000263009021250030012068000250003001006003000001200947000196004
SP74Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;orale00420000000116443600001200340000000020029000847057000000000388900602088000003950506501613800760027430000107060000420410000000009465401133500000001810324340006298620000000014302600840151513100026018000639400003000009174137278050103362097002870000085080000701600000000006100108691539836181108007015255126122194917016202262090087029987408670152391526364370029092211304261858182179034017618601542164377441407130621163800144288656577217712505084317597088517220601031107650002983351219058015743080242659292035840593741381022225399780691732502240010020817808609493331811795238028279503532701611905067290211836505602512020375172055035601282551120100758175153434132144596006429564015732371976529231404821797132213245110019301134761930360843342011540013429267002997010872173114
SP77Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT3082877949616160493480313133702192116023231110110709009094015018227002812215231180120010014028450137420486010246260272531553102209259150120013181701140991080087049529046601320810421689904560892073312725361348526221923951134440000025131074101741221900025116041016253109422109444601912202020143645288011737816025810098372733072015002214120841117174503163006401550122883154433662123806152152928285613741256878552740138312353598019245614933002045408294227103801619611535283030438470180555786010301991906836192466558213950533425604570105584030332870215029632663152765942413369911413020230402552497183115828091353207100194118241561222927041549531490638521132101890234732488501321655695527381893092539215130150518975001045366798222091191444922964215562117229710666819146024046146467321571007415171619714360107233958529626063437607401055922012724981515741633163800225150130789107056245603377420541858147737217718314833441642024001454775148231516737337810531820458622391610813196706553801269178228
SP78Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT138350150237303340600620606127900024003102802400402417015345566900851284076210936010112717014764325296320016301001028120034902220968172706214722060930649171010174560342614000391422201903241058832730121912180931002540368043001142801310531107041304029292104562910522133900002200633117114839446101180516660294250120428183471135445001231980420151872568246004871681205337005000000336000017000000000000000000000000150000000000000000000260000048000000000000000000000000000000000000000000230137121000022008058000700000004011000001801667380600000000000163230000000002000000600000010500000001000100000040000
SP79Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;loescheii510013030500130000000000040161449000000153000066021498637100690046300008280140970016010708000009700000001101571632501100000000059120135736972593091026200952010302000015310171003047000000000031141500634000700000048603081506977730298000136502503610013160548000001483000000000200230900930005100003480017099490168039800196002240000300000000000000000000000000000150000000000000000000200800000000000000000000000000060050000030000000000024505800000000000000023220000004000070055060013102100000000012604800000000000001001261600000000001311700308012000034000
SP8Bacteria;Firmicutes;Bacilli;Bacillales;Gemellaceae;Gemella;haemolysans380050227169318006901743620467600330465260888728903163260105018356961244187571922140171011562254202610741107887665462100950715770813554208710110363481058692090013335710012082791013020557518815112301943866150015590650143201115170053087570344200085136573304814329364021281514059314122227342411074891460044271611702478050212145162050230355706418270072340196725108548024263700203319717213158401717722129020416128450196115728233250559383607542781209332581472872292372202022662144298282422571321138861615318804550256420137135614934017561314346147189242881154969939721001533324555177313518926281403971874402942375695044228917920381244892871707619410760636953536313120740712523354201833105215052535304558353589767309310624131390156171146381955207917372567907338138510354541895293784133572197279952751442137848171599975398222317883366129916062129219718542793558957249076923631035852131409946387671166406011024246042236815471304380627181857674223368240543522054792676412610810372561792591149415119215141053111814353518784241690394024651871914151671267
SP80Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;naeslundii49141560183870246228791998618500915424443761379593328443289468351425111437957927422452733210311100114851379896320291602485244110029561105232436442200389249229733728301664991503444151531369753714370923846162661801556595110061816269329121157473820243277678117283156585388589371994184179903015202568511248771832611648667197148513333301412821819979962930119040385993372921193198138711571707129521002746177519411181459184616522472140810861220719449631750371998832892711160234601135929781729296946140658517031950244965045485023579482939873228382275156935360315328308141226515591609382314943861330116233031313258437797097463881401986159080653876901268167218802719255159956030088447561795036919066420951629841266470712641335117044236230121500059322921018801900144200002004429018104480000500802860001101722349218008622334230200007002960023100432400710901800002601302315006108112703126959174720264357108013426049215161642157131324203361714579050167020032131201422207015905265974206222232468741821165366402797597384314412143387713347132107664169388150102190173643782500940960902182204984143721038111829
SP81Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Olsenella;sp. HMT807128502119900166930470000510007810265850019000602660140017408487206087800000870051891654002339241824516147690033904636152106015518582025900001298413222204300023326665063721654900171413203662313117320400881533010620544920150456068015271691201812460013137710890886881012122310833004707018701989702172139000003293370260166034590966611529254658306212462395772089003790571359914207423377502923141211640120814391908263551962828033013121498202893141512266730126413191472771594680000000300011000000000000000190000000000003300000000000000000007000001400000005000001300000000002416000000001580002685000403100061100905080003022131500219013700187000000080027068173308011000310019001502000070190100817819072107751100004908200
SP82Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;rava32409150021280007049520000000243280000230040000100000000137000001944690083531500007001107012500001993306048021711021480400241200170001500140161714611219320123011614005412092465025600000665146049011141281811180821470045001810002390017003404020687520198554000055150124720123000073617714215257518562964241580970052006800045008106847951200181361300530819632030800038000002612387125015021905280004000673000030202980214382000500483541402010440008770011001570274799070099100000006000020906270491004252610252970571985410100700003070019002915928841961301504501966800290003760050532927806904601090834054744557013017220005494402126528478509100192201021100080005001601300
SP83Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;dentalis15253613972182220019010603001150267588365500095244930002170165003200723011550294813441380852384690016911942062914577422178341073507372340030024502729106111578447476570032473260119940776275619029380418079283921922750001884233280702995716250002503150729762385117905358312656886219703622300204390218882770845904415042210861637937969382228530360021411081192556791780184061379133005825879700488172722084070102983543466203400941592023453137601290634850443049244028802662132533913710517100331595237223431155261840012103762182936568566316639768530070311596273200133489901596128847528420000050000030400300000000330003000000800014100000615000001524300014051400500011000370163050004170550091213000001104251402881427715008045257911011042812610180033098612302904241001512016009910901125350482495472013038100517147810012214210100025041010420150103011029139440000572231622
SP84Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;socranskii68802320100333226262004314629136002210144595429161803800728015003001301848891603214592310233060174431293004843074033834011819531959723012510184235883184223042730497376354630468401554111201091691916053010221051421034040510977892426824094930356102402641257083411341857831314311181673622214365831874351164365204676065409881894829480001340010613991274021811325141446494285804122433049886791190131149714138460111426719531475312791263124910492619113610953039905994227210462046351444551030925171383340000200000000000000000000001900700000030000000000000000000000000000000000000003500010000000000003000000430441816400057211512308006045400514829904000080004540040000021900170230300051577050038011302083670720000046027300001010900
SP85Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT1752175184018605117347288973061141229448925340337116962030700400926527633395712116091714021122977922156117854565605283821266890425424733791852701195144118743315375228252407385662209491817100904351110754435194422571933291928816781430173133654937911380259203884479376661096022571180281610105379132691362244098454051641881504179324623330085003011373215059795481378636622714631693212917785705536761406486314210051013063534629121014302713435811522378154931186296205904746118237525813218022670132581326104130319940897124415727160237318584170180710908254314456231000234410603525566956513073877291791347701121943237431283351954346697553878215033221041442181961903371817832197011161465869313837537026480379036056173488251735172935037108114221131900017720001253171983727102141101506339486006933602730180843457110044461716174772391641117142519021000151052821242381600449194711058151397616633036538316854021493240179549884653140288360440532361244235217712965919401707721831501711787279349411810531565641262717055727288404566310516841620744712734040303980461374421693129521214491251061611587123160064168
SP86Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;mitis1423056101711857932791311343173137220440197135164628724501103033751711937038144728527864247218307405246743523021467085906750404652247628184689685017616617115182325188276203313901021174309239645064654321181212510811564958658239035924985891012103389877633434712406624028346798088824140771061841231091413197104234117616326305541066200350690123105443429353885913665711884852522659224141978666415142458211854168224911205213034918310671031627360523231132910952893329622205371103433974474391958042501511401104264415513308771471397832698795716324358330712745214156601003168276157054838059316903569785255714163984241261634566915101125745664613164051676166189934941338514749553720238711319240168414236551051783753151252599138802982291423581297242212014743917414225981564141411143035085421912937960311443438159528549334125532591219882144849255517807402286854444379032315661278338168107676211919804032485157282112986234192637556076816301484112509378439042007812300141100216825091045524117141814066803257046524525726315914311129132464435301686530948450953277885110799839510982074872793943005962010001637031572528102022041149937631713303870533531391685528524857173055452794291895400318948259916646645258301903410216157293949484137155021764110591265424262006103338369935431829761121174885394701094033408245310062668242037258136
SP87Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;sp. HMT231309003500837016400401326000410779030703000096200000010462123221264000000113701812246000751142582050170130205000261509421181911192800078822013500210156331512775200002130331818811047009072360363072701100014250011515402327442551724003196518011295069108259323427040000001814041811557001038340494289004521415206570062483052020712661175189400731518250109200489057900168189516183700621011824120369200000000002500000000200000003100000000080090000004000000030000000030005042000000000040000000000000007009000121187990046724060006032400600001210001600000190013768000018027900030019110001000110090041024023709000840000129002931100000228321
SP88Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Oribacterium;sp. HMT078350134171100363728290416817256320316109600042601621032000013919823092550522516511328376027460561062505573808051075044183337500042553023640916654301600211120222311300175258790868452680227169018392516411148288071010292930651192957150013906286200622872151121071734599947915001814613142702392376343493525986831260132461918743613355510301471034106266193362324277394724264051453032387191606711871851222177911371172721964535913912745672516015496527221339169179312150435811994956121131410000000000070100000000000001548000000000000000000601900000000000000000008000000006700800000000000600000020080127902600001031634004517770723155024262008001110121000941990112070949080705194807072111001112024032004813210061000141100081527901501509400
SP89Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;leadbetteri3600202637681530448247503858290016681518285115354286044668740971585312949502595115221117088445917436573181143172959535713672250440241882249405280423399158185741472702812698569802891810281433884545601313827822107838752116329992580564019548164533246903481048373220210144368342637147232543123830922670754290717801270781335437894068345511134539282791112550129916081898682272310382325666319841040493150533261125187117732265470368228946227987601342065226096549791882192135392168012377602774168179621208316642119112728810520353321481041063081121718837981674134813720001357358215204278458210062429930229473944886258073990180758401251525445025011224196217994841105179649796244540638382221033319242079900251374137523161113163139292800092682334109961171011338369661499137839358214837845618421629015286015109141490531891720150309000041510111012182313203071419231788450388419126641011100415427123701294217321513923713810645245362671672008971076274969012129743194282067457839149315281892141357597756455540121913688376560103813420584414418478310347131424816944400902528916611084213382293508546371171137123979059328623078303364019181453063241
SP9Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;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
SP90Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT136008800000000004100043081300000320000162000000002170000000970000200140020001420291600000000071000124200000011001000031007058101320650022071181701000119143005800002011000059710000000009000461000018900120360037075616032224213269002200005133000157349117001001560040038110011111050270530001209813423051523003330715000025100170003010941602624101780214687024107800029111153035401852540120488980180200035431805311688700360083260056424403103930035861137392790397118223492252475320700312317356711307185151216432891050361922611133112505101890011645614293812109321170892161046276461603011110314501179631161707239412032720123010
SP91Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT9130000000029600601470011000103097000000000000017934580018400174000000000000000080066012800600000045000021900400001588970041002000072300000000002401500010200424000250000000000187240004347260017706216000730000000000001997034015003750003100152000043700900007386900106098490004115000000000006011080000000000000070000000014000001000000000000000090000000000000000006000000051200603000040002000000018801502900460000000000066009000030249004108200019000000000000410000002600000000000300021000014730047011000022900
SP92Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcus;stomatis249008045000007249562700011390410004600110085001133706024020000330021200035700659015330003604419411359112404087115371108111113840784001840300319082700620031870014040037120772014090000705079273802884250094279158600305240234000149406315205612670006480001000563030100069289205762470002659481134201494971439046454361613711250610668960140017062701048141418697670617150071300165414360765341730884239807093033416735194084315450022166241509056866850014011860132960811220831450103941011143566010878001631460876486720299418816297812424991448194599432225044718336854637209071203660104327453210157004512378322567181479736047096036240189463571010854850557770654352211890029528610219133931589648415350887019219771481763160123681710620164968141457457188931030215128611433789621371126640371635108122227344996338928914024807310365074744824126423740334179358260171497126327300
SP93Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;sp. HMT036000745076800000127000086701024690022081000058896502072003500093250155031000071950000400081500005701660731780012210200026167015663400002600270234000036310210000004000003840560197203107100003967040724002000012902801100000450090000007000090170028000072560201337021506000027001401810000861080435600000028530020703026168807820670000133550501806521400194062010000414100130010029055000161603355160863802219000090175451000025100137032017000454136202332546029042972402770082796001671161015163992501669420004203461236975706765900554196022703170008934604398001710194491241600281127013059626030217106237501306200059615318900001832924688047454
SP94Bacteria;Firmicutes;Clostridia;Clostridiales;Peptoniphilaceae;Parvimonas;micra2180090712530530020015670041280000002001624111080560305367569782174522268000203410305015337510590013322616516020386070423020913823719901135476033036039114301112100056750197254377218547110600041153023980121028465230206880192430650156194900107310391404481130404810416444802111366751978630379315888011212257288992231049984400024774563132602627751261005120245848852194306603747768207400519491175713010220811461082901076353183160663121105339036882261151744555930105000964176839003310303811834110332056000531310190001150020010067387231817308634041015341803603620007001134611133802024000483270023009026410420742027974003030607190776001222200574191197707111940922901470021338351150301832001067188472125724318960247817624933706163721224003591630084218760157519432496001901650248103011400905824327149190281578122278372602407503215459992008
SP95Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT219000346008809700462001180000168032170099999003800000339717400031303337444000210826360020003865840000161600016000767034300204698117000171630001211417007720108431100451100000099077288022200118600336700002709220292100415900240000819414411001060112786100110500080039023123700007810008000357011007155720000800018450140037901684427001584018000060000500000000005000000410000000000000001400000000000000000001100000000000000210000000000000000000000000002410800110029001160004100006104800000000023000005000050001700061001100000000000013050031740000150000010000040000164000
SP96Bacteria;Firmicutes;Erysipelotrichia;Erysipelotrichales;Erysipelotrichaceae;Solobacterium;moorei13640190528322920076857715504100016246044000550063425001161127027471341240036470630613192110124961858853156223283112891072460100167163719403870700651781460110624270111472113412003021131153850343143079742800298911913386095211926553759292524244020841116972920152387192343140738659611421492788500284795115021035117901588275592718385801385271177881991729592143170538519251612831409343338590950422064813890060028723919163200111266001011630116924452175831620144461142822270137734734732240116620293778158825641727117318537136952653424550943901353319454191127131334227424349461141281003373023113111102094014029340951331898085942247466139324902426108114726910122061931549802012048271912962658702251924971075748752137892104352835681166616239323319791231381972052381926811085773745191461414252151635615795461074333522124432307883892471924892610726269635312858137239158350306110051584517646100131180114387632292157702441912577063782323381161288999138248136154282143283100015317928060031218163672268105516057
SP98Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Oribacterium;sinus002649041331314041559016031006215190000001821135300001300370035422611100001500062100044464529340004520000100977110000015110301860002801306412423371900151206402500108205608601455230481466602012011005322733390000007090800101380605100006678014362346413711001840001700583529700190118610121800192001300305135018020055410265553109673517516812184672031055454481473405575363186265877574160846632431200545365130011233809425411632527372564321037473232143222463911933900289578172210389519537692974796161124532590512122062212003812921187329534413548420120484786106966753880061348237760298137421349177417140734478514010335486965023326718611122473821797990200839142258851462528973612462179026973868138552677800437622352810654879144691502296153162831336712474159344417732134460236209091923962461249114258100111581477175314447193085619209463391155389263148332117600368520666655109631413582692726397771230928222234785417046010176508
SP99Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;granulosa135824535328697392080411452965144617476340917305941580355124065922706765429840590390052772641486345181201902159132343654210529441542326105132051179017322440339215225251657720035508868231105815852348170125245527207787271002759833453380289911505194173127920331842278395141180631341732129915131319984711348079372495565112330005163491188631186174411525420470198273210081315398568907052972340328196713345836557583310648054201022517194915450449503179919496339310165303967710183812467146901204261200938935210234857254219012987725571617904490159075704502234123810955978781509141861403471719138541784911032313314110211468384121001368266013513612109402971899500690010017800000000215405210010060400123807713250520031001800070010840419000044000000100063800000030000100030190498011011061000005029185610055644009131098480160104280063213266481414000017387679072135464374845641622028005719213310380492418333860080048017505794523002723008026425330612172772153747131021170110
SPN1068Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT175 nov_97.746%197453805781923103405001647802329000905745013192310132806918459003600001467511002000001368769807087194901214067327261180182601245103272501065564560509900346021902385342601800001236355581574780014219580877160216203790916453660001212121242891004482242018954403978048801555900000007188292044270024521903613318540677011323743770319051440245190156767350393120047206915172423002000001314994180000581720921974928150061120000038607001252001000038000000000061341600000842150000911025178000011510613006925001000021901428000000013320000001512000131025305738253000007913610140002935600400160000618000000537273100120010434820082538737066124390500127521341001168900000150260285380000000138180715005710800036
SPN1087Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT308 nov_97.347%0000780103000004128000000200060000290000000000000029040000006270105000000184240000000000000006000000000000001000270000001800145000003734000000000000000340000000000000030210000007750330900001006520080000000160000400000000000000405000000293491441629800003017389000360008590022000069604001710000000000288010139000009891030208193020140809363430032900025300710000322060016000003000110802931220000055910112129901500501872199115023390023525003104100403059024160000000007301323710090011101320349359700903029323100590001068006000030000002600000600012830262550
SPN248Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;parasanguinis_clade_411_nov_97.976%1350000003000000053000000000000000000000000000000000050000000700000006020000000000000010000000000000000074400000000000000631000000000000000000000004500000000050000006200000051000000000000000000000000000000000089291160011200101504122832580805522134405300300000940160000677143071584500016000228328706126003360022726718337300020140034016000290000130335000003501351305000103001071114472271100900008441115019006015550740803000000001000800002804103235930006001537831115420023200117045311112000152211049041000000030030000015093576000510020444
SPN255Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sanguinis_nov_97.782%109301293000014720000000000900701175076926651038900424353037801200085700098700000014465321780246400002766000000000013030293603174330393008618214102790159300004410602321519000006641884030269000041200000000002474017320309135804030040121710286090000610100389700000076644012409690000300000000000017905501087610001426002728169301001355000045080869130000037618320140000250000000000500901840050010140310000002202397050000001566904500001000000000002005307760000862401601230000805190680000062391180366000079000000000045208401382790109004964022012000013405390122000000704343210108000011300000000002010860599250450051176101320144000036050309840000030682
SPN323Bacteria;Proteobacteria;Gammaproteobacteria;Cardiobacteriales;Cardiobacteriaceae;Cardiobacterium;hominis_nov_97.510%00055333710700115931363693004320001208058364160138000028000737394002280021366170700014805003096793600122785251537102003562000033837180050751259000038000306127009140165935008111100214000032358784007337747481700619100003392000301116980000210005931890066300112724010000220150005655230011154001056790014100007923929061945350000000061667007406081282002029001570000000000000000000000000008000000000000300000000000000500000100000030000000000900000000000000000000000000011232110043130161000160000000000150000000000006002500050000000194000002012070000000000005000003000000020017000210000
SPN335Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;gingivalis_nov_96.429%000000000141703211977972700002370790001100130115701144164800724197618318640000507000000000000229431339855000000002410002390070060002093600381180798012700373000000000000411539629210661620120012400320026000402313032149369002895808980000574000000000000183308168730000004802200058000303000161610013225611746000078000000000000600026000000003000300000700023700014400000270000000000004200000000000400000000000000000705000000000000000003213164226510060054006201307400002540344412013166659018001170000000000003338033000000902110000080015004191100088047060011000
SPN347Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;veroralis_nov_97.342%4100360000000004500028070000000850056111000140000736035600194500000800000000000305400127802320157000006860138434101000300000108800000000005519000000000000750048410149000000125704435315700011900005940159600331100000112470050000000264045007552570120605500910321050033743800040000579024600330000039000000000005030080010000000148041670003020027059004000000000300000000000015810270000003470014330002000017004000000040000280000000407230197280332000000185064947000033050012201640010400000223300430000000004301553802810770000110005751000330000159020000020005
SPN358Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;sp. HMT172 nov_97.732%00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000072000174000000890000000010600000004400004004140000000150211001440669000116100000065600000000288900000003000050012760000000007150018205800010500000003130000000016370000000125000041002259000000047057800105088300013150000001037000000005754000000000000300024270000000001215001520
SPN370Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;gingivalis_nov_97.689%300017018073440000000072310000706970153327610000000156900000053000230400000500031624314500000000043000013150204180134300000002400090005700011282000000001281036426000000000630018039320133785709000000014990000001400014880000000001482742460000000000000078940153020941000000100000000700021700000300007040000000010000000060701900000000000000000200000000000318000000000000000020904000000000000000000000000040006280140000000005000001807013232000000230000004000154000000000015228000000000000000130003215000000000000030000160000
SPN382Bacteria;Firmicutes;Clostridia;Eubacteriales;Lachnospiraceae;Lacrimispora;xylanolytica_nov_88.613%00000020021171241912635000000240002940000036720000980402190036333000000000499370000012200312016221189200000001371617300000003550000002486209340014004100013330000000550954229180000000023022088000003070000900592016112000000120237207000008313000186717760411130000006940366000000050100004150066801136818012750073000532000000000540000000000000000000130000000000000000000000000000000008000000000000000000000000000000000000000000001204100214300270001400000000000000000170090220000008280000000001000710000005000000000000000005001501200000000
SPN392Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT300 nov_97.347%0011250150000000123000081020000070000039300000000000004503000415521702201440850000930200009622015404207009100100460000000000300050400375243770385530132200000100209701190144157050000110015200329152010000000002204047700748231210009727169214200006864116030335880915019305283001230056830107910002000002077011900016834993600500400000050000000000000500500000000000000000000000801100000000000000000000017001100000000000000000010080037023500000031700050005500070030017200000000000005018002548071464328000000250207400390500004001120000000000000000003906
SPN404Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;matruchotii_nov_97.755%00041950004100001829002402003234219021827803760000228100000000000000000000230005818000000031721310025260070598330012136066000004205000000000000000000067000036050001400014058730019140013572761004614013590000246300000000000000000000000010270000000100444300549000166600274001208000040000000000000000000217000000000000000000000000000000000000000000000000000000000000000000000001500000000000000000000000000000000003600000000280016001341004208000000000000000000000000000002300000000340000007500390600000000000000000000000000
SPN405Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT175 nov_97.951%0910355413430005410422973222320015800160717003642750018309420005900004222043140400032002233004402153027341551850000031000053310000374270897606105001002451200009678135000015001433721278200000003260000082000261148020330102000030014111600012003000009000107331180000000000000000000240250501350000100703500013700000020000016000000000000000030000000480500000000000017000000420600000000000000000010000001788017000000003600020001055305800006500580004202050000012904000001202830210000000781770000000081012902100700000000000000091030000000795030000002004700000
SPN416Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;naeslundii_nov_97.963%0000000000003000000001700003800000000000000027001550000000000000021141000002621000001280022665000580802000004000000940000000000003009223000003960000018005935344000351020200008067000282005900000000000000187140000025250000019900389760008470490900000520600001420000000000000000000000000000000260000000000000000000000000000000000000000000000000030000000000000000000000000000000070500000000000000001500027000000000500003800000000000014080010001600000000015000500000000060000000000
SPN427Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT137 nov_97.228%007378471800000430005037690000400000118071960000000288550021028314229308000003041316690000017500282910910000360013023501422000000026347400103000805749000260650294162100000451001031929113000081400260150045000000099400090211432222400000531314700000018140001196325400001270065307604224000014002381394001620200680048000000000000000000000000000000000000000000005000000000000000000000008000000000002400000000000000000000000000550260000000009900000000806024000000000000130002200000001001700000000029080000000004000000000000008040205000
SPN436Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;matruchotii_nov_97.967%00000000000000000000000000000000059830052134600000000000000000000000000000000000000000000008050016007200000000000000000000000000000000000000000000004679008090000000000000000000000000000000000000000000000080300884574000000000000000000000000000000000000000000000000008000000000000000000000000000000000000000000000000000000000000000000000000000000000000004000000000000094000000000000000000000000000000000000500000000000007210000000000000
SPN458Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;matruchotii_nov_97.764%000326000000000002427000105000000000000000000000000000000000002830000000000069910003575000000000000000000000000000000000024200000000000279600087800000000000000000000000000000000006900000000000731000319000000000000000000000000000000000000000000000017000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004900000000000000000000000000000000000000130000000000012000190000000000000000000000000000000
SPN471Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;hofstadii_nov_96.970%6700260000000000000000000000000000000000002720000000000242000059000000000000000000000011100000000000280000000000404005196000000000000000000000000517000000000000675000000000043000286101319000000000000000000000010960000000000079700000000000009018000000000000000000000000000000000000000000000000101000000000000000000000000000000000000000000000010043014400000000000000000000001400000000000420000000000000108089000000000000000000000080000000000000000000000
SPN480Bacteria;Firmicutes;Clostridia;Clostridiales;Peptoniphilaceae;Parvimonas;sp. HMT393 nov_97.895%000000000000218600000000000000000000030000000000000000000000000000173900000000000000000000400000000000000000000000000000737000000050000000000000640000000000000000000000000000622100000000000000000000400000000000000000000000000000110000000000000000000000000000000000100000000000000022000000000000000000001000000000000000000000000000001060000000000000000000000000000000000200000000000000017600000000000000000000000000000000002000
SPN492Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT897 nov_97.769%000000000000046390000000000000000000000000000000000000000000000001380138000000480000000000000030000000000000000000000000000031850000039000000005000004380000000000000029000000000000060650378002100938000000001900000110000000000000010300000000000040000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000070300000000000000000000200000000000000000000000000000000000100000000000000020000000000000000
SPN503Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;granulosa_nov_97.468%000000000000053200000000000000000000000000000000000000000000000000900000000000000000000000000000000003715000000000000000812000000000000000000000000000000000000000000000000005000000000000000000000000000000000012315000000000000000160000000000000000000000000000000000000004000000000000000000000000000000000000000000000290000000000000007800000000000000000000000000000000000000000000000000000000000000000000000000000000000008500
SPN514Bacteria;Actinobacteria;Actinomycetia;Corynebacteriales;Corynebacteriaceae;Corynebacterium;durum_nov_97.904%1841870313312232945304682801470969311039522536348710321583241427039293424910098619200123053189480378151468104415373051610927390418817168416442066136902090801170431992020122511131254170462174050890313506131392013386251802183122831207136914002124453803481210106313055417002530051845602800322103101619359593051191000116970028137183833763814116268915952361318061103261500589164039700181422167000295330184532161700183300564914900903717177132519376611262050858014000240701170090002274006531200600090110050037008158811002151709805011033000400523400016364204290053200021800080301075701503650013256605440685403200722796307022741222037390027605208213001404145148811037107811181549835018281335091079655046000833430161552600118307430031053430093204312541041010348123701120
SPN515Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;gingivalis_nov_90.546%00000067060082022384000019810065290000400000005500200120469000043503333300000016000047200000080000176300000000000006600090550840028307790000000000004094662000125000670700013000000022100420002290000631027817000000100000206000000696002700000000000000300040240140014304270000000500000030220003400310000128000000090013000000009290390000006000012000000900117000000000000001001000000005011500000050300702081210006260093800024200000002500240000470204791034450000000170000130000005200112210000000000013301909009073078280127
SPN527Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT305 nov_93.865%000000000000017000000000000000007002000000001500000000007000000000001200000000000000930110000000000200000000000009000000110010000000000000000040040004001000000000000000000000001400000050000030000090500000000000001707200238194913077121240257102521170546013800064001870303400207131149277710215264810410005706604001481187372213953346162140656001532020460014400100017134022764175496114074808786152012236013606900276124559025040210073247042512200246029314005500194058343032517882316540108219181345179012670520700381704895138137133010315083800121103368007001320341860219150114299124014400169153540215510190
SPN537Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_94.882%0000024003222000000002703200000000000000004900033400000000840000000006360000002460001819000001400022000007400657060000830001260000003500199600000069013082440000000009800000303004711200003300033190000001200121800000038017001703920000392100044000001165000195000013000871000000000000000000000000000000000000040000000000000000000000000000000000000000000000000000008000000000000000000260000000000000000000000000008006000000000000000000020000000001602500000700000000007000140000000000
SPN548Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;noxia_nov_97.030%00230900000080700000000061803300000038164030000120101014000000000001060000000441480000000007050124100000085845050000308401670000000000015980000005182900000000021203750000005182004300000084040100000000000146900000013466000000000275013260000005848600000000130530000000000000000000000000000000000000000000000000010000000000080000000000000000000000000000000000000000000000000019400000060000000000401400000001700000000001000000000001500000060000000000601300000001000000000000000000000
SPN560Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT215 nov_96.963%000000000000000000000000000000025905390040000000004300000000000000000000000000000000009204150010000000007520000000000000000000000000000000000105005001000000000000000000000000000000000000000290000050020000000000000490000000002500000000000000000000000020701284270053300000000029600000000002990000000000000000008000001080116110035500000000030690000000001800000000000000000090000023806559000155000000000124300000000021000004000000000000000000143081118003110000000001468000
SPN571Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT215 nov_97.614%6200044016570285738000141683000001134300002804010700000008500001310006900050000300210385264000031000000040100028406301300000000500001800030205086000160125407795960003527002500891600000609600000001240000111000000630005001810354226000011300830011453000860360480000000000000000907050000806700503200081200300388430005036401400000006000032300073000000000069016310000080002300506210002301940380000000000000000380003500011011600631800049290070068231000601830220000000150000178000490132440000003901102900001270010004912100010069026000000000000000017000
SPN583Bacteria;Proteobacteria;Betaproteobacteria;Burkholderiales;Comamonadaceae;Ottowia;sp. HMT894 nov_97.286%0000000000080100000000000000000000000000000000000000000000000000580200000001909000000000000000000000000000000000000000019700000000000000000000000000000000000000000000000000792900000000000000000000000000000000000000000000000000900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000340000000000000000000000000000000000000000000000000024000000000000000000000000000000000000000
SPN593Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Peptidiphaga;gingivicola_nov_96.920%00000000000000000000000534900000000000000008200000000000000000000000000000000001706000000000000000013960000000000000000000000000000000003880000000000000000293000000000000000000000000000000000108200000000000000002804000000000000000000000000000000000000000000000000006000000000000000000000000000000000000000000000000005000000000000000000000000000000000500000000000000003500000000000000000000000000000000000000000000000000130000000000
SPN605Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT137 nov_95.842%00007300026680140009200000000000001040000001086000000490007000285500001900008080720007000000030000060000015000000031000400013500001700023304000001380000000000000390000031600000089000000428367000080000250204400005000000001000001200000318000000389000300073000000000000000000000000000000000000000000000040002000000000000000000000000000000000000000000000000000000033000000000083000000000000000000030000002400060007000030000110000070000000000000000000000000032000180000
SPN618Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Sneathia;sanguinegens_nov_90.792%000340000000000000000000000000000000000000000000000000022000000000000000000000000000000000000000000000000001456000000000000000000000000000000000000000000000000001527000000000000000000000000000000000000000000000000001370000000000000000000000000000000000000000000000000016800000000000000000000000000000000000000000000000000580400000000000000000000000000000000000000000000000000230300000000000000000000000000000000000000000000000
SPN627Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;naeslundii_nov_96.755%2470210000000109800000300000001260000347000006570000012500000329017470160000275600750079915230140302300242568051080672381296600006777000009500100148302240950080052302400732429063022000011741331503345064328943481010406177600694001210000028710981725136058430401891058001289154501911707300474214072610171094086010000072108000257001140000000000000000000000000000000350000000000000000000000000019000000100020060000000000102000000000000000000000000200061300055034001420000000008703004311000000014000002700000330730000012120021001220000000006360002069000000000000000000
SPN629Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT284 nov_97.746%69005600000200000000001711200596000000000004903000500000000007500236600002300220000000180003580000000000028300000000000000025900176700006000000000018000294000000000031745600040000000000260012920000620013300000004500010800000000007566000000000000000000000000000000000000000000000000000000000000000000004500000000000000000000000000000004000000000000000150014100000000000000024000300000000000340000000000000001400263000040000000000000000000000000020300000000000000
SPN64Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_97.410%009842516001496006100113290029500136234260550000047400003855585018951107553740510000740322370027780978800132600537001651901455603661465041001800059108100084206950190944997101093003230465041815002339559175389016990077600791235060843021164011421269162460009128916800338344460427674120283000012501141024743005742365431850128801912263501388301172163225288641596537091400061716146500446179174023208181223960000170201402019821700000000000000000400000000000000010000005000000000000000000000000000014000000000000000900000002500000000000760191210000000000000005160300033000009000009000000000000001056090180002500006250100000001000007000000151120006023000
SPN641Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;concisus_nov_97.397%00000000000390000000000210000000000000000000000009002900009000000310000000000220005000000000180040030000200000000000000085000000000044000300000000056400000000030060000110000001170000000000270000000000600130000000000000000000011000032400000000002880005070000002015001240019020000069089200000038000010900000000001540001224000000111600380280190000145080139000040241200014400230000000101600028100092001936001200013320880000890222130000012331600000033000000081100016001003700036009706300820000201029120
SPN653Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;haemolyticus_nov_97.947%00000000000000100000001872700000000001280000000000000443000000000000004000080393000000000000000000000000000970000000000000004000024014098000000000000000080000000022000000000000000000000046200000000000000000000000000880000000000000004000003500471320070000000000480024800000001100000000000000613000027010122000170000000000742500000000020218200000020100000303000027720413197070014000000004102583852602000200006111000000000000003300004780310267000200000001002202589000000000261513
SPN664Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Kingella;oralis_nov_97.741%000741061000004650074100001613200000004440261025500000000052000011000185100201031150000850000005439800000006308120313710000000001660002000260002204600000195002800001786900004800116403711100000000001650000000020007600280000940073000084700000009190523000000000011000600060000000000060000000000000040000000000000000000000000001500000000000000000000000000030000000000000000005000368010000001600400000000000160000000000000000000000425000960153000000000000000000000000340000000000000000005
SPN676Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT892 nov_97.041%0037605000130006510190000000000000006000000001010000003002320002102910000000771010000000016000000060000043000000000000260004670600000000537041000000000000000020300230011600000000046400167301070000006617900152000000012000007000000010000000000000300000000000000000000000000000000000000000000000000000005000000000000000000000000000000000000000000000000007700000000011000000000000000000000000000000000000000000000000004012000000000000000000000000000000000000
SPN688Bacteria;Proteobacteria;Betaproteobacteria;Rhodocyclales;Rhodocyclaceae;Propionivibrio;dicarboxylicus_nov_93.802%000940025700000000000028000790000040004403046011104000000232042010001604054740000165000000244022107700000180000000270390000000210146000019505579800000000000050008000004700003205287011290000007870480120027036742200001837000000140040200000046000003320014021310000002990740000000000000000000000000000000000200000020000000000000000000000000000000000000000000000000000000000000000000000000000000000000000080000030000000000000000200200300000000000000000000000000000020000000000000
SPN699Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;catoniae_nov_97.342%000000000002500000000000011000000027300000205003690000000000000000000000000000011100001341712000002150000000074300000000000000000000000000000440000591673000003000000900169000000000000000000000000000003300002647800000000000000143000000000000000000000000000000000002000004000000000000000000000000000000000000000000000000000000000000000000000000000000000800000007300000870000010000000008000000000000000000000000000002100000107000001500000000110000000000
SPN711Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;sp. HMT908 nov_96.920%0201600000000000000000000000000000000000000000009000000000380000000000000012000000000000000000000000120000020000000000000000000000000000000000000000000012000000000014000000000000000000000000000000000000000130000024063001390042800000000000000200000000000000039000064280000007500123003019000000000017000000000000000000000000220900003004180020300156142075000000067100700000000190250003017200002031030702690257005870016216400000000001902100140000000000110002000000220078000
SPN745Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_96.838%118053002000474422520181000820000002600000002213000001067038246190124601600000010244542714154001515170683418024711306006134563800250359000069022475720000132903700281023303900139024020814935310219034040036821132301586000551689101000066100000044709960000733091039702118050005201070301126033705001032002416245959481117001551456271003070774000036402885623690000315045254880293094600832061030303810003110000000000000000000000000000000000000000000000000000040000000840000000002700000000000001217000000000001604900058700000700000000000020000000303300230000160000090000000270000007000000000000000000000111608263000000000
SPN850Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT473 nov_97.546%000820031006540000000068000001600000000413035100000132600215301800040000000000000000011600027000000001402715000000170066050000000064008003000000440000032800000000189083000001726100002100000300100019610025000000240162000300130000017011400006000042906990000447100139960147235000000001008409310923003071360308012176436185657610000746612002719316390001327001781109612360000000023700240166021013115000201870054601299000010455810304521600000029200764001007860000000066912801017034100176810901812138284476272740130091740700131616213220002600034150465171050000001103402801020059120604260701654103700001189411490973730150
SPN962Bacteria;Firmicutes;Clostridia;Clostridiales;Peptoniphilaceae;Parvimonas;sp. HMT393 nov_97.053%0000006000000423061000000000000000000050003000000220000005002000000000000000000000000000000000000050027000000000300000029505260000000000000000000180009000000000000000050000006000000000000000000000030000000380010130000172819024902931160457675501011556001123316329030186006370075045731909244364023800125801855000326605000012936103750001100483987000001839171596000332604100015098112089300058002320207002295000000428102180286164042047810859628004983126520309800990036027181819201234882008390339000021220000001975201250001701108105000007149212650202400000220231859223000213039305900730000
SPP10Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;multispecies_spp10_231200080231100000000000000000000000000000000000000000000013100011721292000000000000000000000000000004000000000000000210000394423000000000000000000000000000000000000000000000455000756931000000000000000000000000000000000000000000000000030000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000093000000000000000000000000000000000000000000000700048000000000000000000000000000000000000000000000
SPP11Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp11_213188488170155897102490094929121997917281608725138379800297082915820515031112176060578138655005210948402019253712067301941113102175020400222825792662341560031121627119918622206621088189350138722002219926252315154741103473452326600651112506085549632738144101900171911132130302030182510041487111071131238089293360601651101212844035662602410024317431223104380031161727729920555176721005255853629100737004213204072706120163810497166385488174558461237437135044373801495929991591158602469399413024740821850736614110015596285355980813292734212655335814712733728181328506369146351266183861801024449716032180891891181123406493021192143489379697413223971368253231671335022431487681774446764146233984234959123731334431605568374606711783146401195606848219262207505980089759238525671500703236042570532121242530208812021210812751484567377128472499316529792451445357842909992254632794621107573148633163181554953750504163256470054115552159815422040100833767168172230964475487892799088161931240425823729472977762748358271047627623892347124119032650248780578111053399133026841035117613501132015675352950003338254315990895164625634217223216860711141238589741732071651266934601445201817801468
SPP12Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp12_30000028000031000951000100050000100000229003700009011000009000000010136140000000019000000010000000002900200000430900000000000000251500019000037000000450001220000127001800001400000010100000000012800000000123185000500120000000022000000040000000000097426371881117171548951706302969374713284001381992295354129145486520920421465250057607749704493471502101122051794596010115022393101246118510606314031873029914002034470260215232661585682143771400123301687094301012028934036213440168018269140811600598920436975901135447551342801672112061988767729186057110229288106432251201460345841643210022753332379646653319613602212996812620291240442413327792243910018044198818239720316102653770181135454348313011959200518200825007010329137009675292754609429012260
SPP14Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp14_3000000000000000064000000000000000000000000000000019000000000000000000000000000000000001500000000000000000000000000000000013300000000000000000000000000000003000000000000000000014000000000000000000000000000000000000000000000000035162000342000000000000800940103000000000019100000210000000000009000249000000000000160173902200000000000000000000000000002616070001970000000000001050590265000000000094000000000000000000370009800000000000027044803380000000000000
SPP16Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;multispecies_spp16_3000000530000000000000004500000000250005300880000000000000037800041000000003100000003710000000000004500908170000000000000790001600000000327000000109600190000000008520027029000000000000008041110052000000009040000001242000000000000301006618710000000000000000000000000000000000000000000000000000000000000000700000000000010000000000000000000000000000000000000020000000000000260000002700000000000000001500000000000001500000000000022000000000000000000000001200000000000
SPP2Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;multispecies_spp2_200000982000000000000010300000000033400307000000000127400000000000001845000000000000000000410000143022180900000000014670000000000000199100002000000000000000000056090003400000001750000000000000115800000000000000000027000033100570000000000501000000000000000000000000000000000000070000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021007000000000240000000000000000000000000000000000000001600000000003700000000
SPP20Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;multispecies_spp20_30000000000000015000000016018000000000000090000000002700150027000000000002115000140049310000000000000250000000000009017000000000000000000010011000000000000015000003115240260000000000000000154011000000272200000000150000280000000001400148926971140419490108215161117325398144325556327011604951036160202916636419742013004669553636104202656100503300879260509961228157271516822034019541738191725513861261961346812353419240373030015302294121931266123615042141443738054718843165001061106929810920986102906515010764521028251859242224114791853011122285326914991006661254981043042979654786401921133159915413870163202745518213298819660078962417319428025097504262401045813011961120198732217282390111754822901056140374717132989232311529580353253637891508489220407720165515558311431206003362541282616899469016934909022670127880599192793131605935921431
SPP28Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp28_20000000000000000000000000000000000000000000000014000000000000000000000000000000000000000000000000000040000000000000000000000000000000000000000000001600000000000000000000000000000000000000000000000000000000000000000000000000000150000002150000000000000054805500413300284000000000000000000002400000000000000000000011007200127800790000000000000000000003900000049000008000000000132202870012000115840000000000000000000001900000020700000000000000868021700395001394
SPP34Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp34_20000041100100001000000500027000000000000000000200000000000500000000000000000006002000000030007000000100000000300000000300060010000000000000000001500000000000000000000000000000002000000300000000000100000000000000003009205200000004000103001205240046700300000004300014930000001500100000181018100000000000430034737300128001500100009200013710000002202000000134722770001000200081004671600123004000000036150038900000020000003081868000000000001500113380051003100000002900011290000004080
SPP35Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;multispecies_spp35_22860406000257177962240054879300055107321863106161009847225640195830104136521372144466726421164998311500771632124591685201891719920515016980266115621623515667181112021401957817158941232531000884911121142045144156690781478152264317139388005025737364917009239064859117602587149621612447301691484661682274405751471300011339045884492072712435141675012225996741213115137503597837139236016538655971541658407100175546509601816281710361460973316703902404281215736286780903177723882970172114801856853625611624415316028421911974119345311531864406256438457598661204008019020100000004602114700201212901297802010370010800238000100101100210020325000262505800000162147023700380001303120311280340141372006411237200222601079152230711026948226123903171731312703330088195333400461777916037512300189629496701068217012019881061104740200860033912953000370231021520466717313044079164382070
SPP43Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Oribacterium;multispecies_spp43_2001572000260000000000000000000000000000000000000003600000013000110000700450000000000005000040000000000153306000001290000230031300060000000000000150254000000011000700000000870000000014820085015000048000050016070007000000212000000283087183137066428403765712850491051668825276108703213822700021420033427290472578697219076149311170301152965963606821021622820341243012132356172692100361701523048031531496678151902212401486223219020138112103010919105112941132667353838813280782034803985219420025166956321515411232339436338556211179500249190309272846765631102206088402432210372625382955264311308859278134127302948050558130484909420265432846523139440013127010978105434197178133023100161812899107223955611874
SPP44Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;multispecies_spp44_20013000035541160000789000000000406120120000000204800005600000000000046560000074014042000010001940340900400000000290000000000000599000105634502050010239406100000002001232350072000000160472000032500000000311000231093001700235594111070000406015433018988519007600000398901882003301700000000000000000000000000000000204100000000000140000000000000000000000400060000000000790000000000001800000000000000000000002079710000000013028719000000000042000080000000000000800000111593200001900002480000000000001600000000000
SPP52Bacteria;Firmicutes;Clostridia;Negativicutes;Veillonellaceae;Veillonella;multispecies_spp52_24993513814690445222499111582263102589506122167171467298561295699619830720414342093175797810091012068128907188184977047812719671578193102887510432901306139326591521912620540423640124321476476939715655381020311681466120692734105053902541335857448105191752167441807353464231640737963789719626282941149130042955301854613449876956932257630324561196552682118803193852266446672446512940761200213248771365199461795820512397704917665990242302527141550165671317294839952221691476362291197847911070714145861133036012244632066125425255815439325352077419975103202684311754517394211134524765675765814172891109200748760243955584926966671129879611742293016263811944231207937503061499238675002693624361114357338023916224482204283655926799144343191942681281549667505994120512552049453150113126125130032639104565229232397115713913687538128477251105044467828841548174340431821407131115923013915276311058161825040251819849102713635420182093053130742202206493114765602300350124798518710682350129913025695346777255325801542064207559887436851304042019117104736713914291234716538138316023421541070400218033967562265180117541025102221043321606604295954516775271035087585095432012303903051785207988011063155929322772666402342783226139468804893121600825572384433158138329481722218330712278186271514881112144423231030310302412512525744794131074209600947795464951231158672409711112129830268215169335195233325169777221
SPP54Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;multispecies_spp54_2213005861537071370618861660000013720220101000045500012010690209943422557455034600198001023903243214200573369919620410913529704320000003506000730295180106807111213000101106328980207002500101700293565800123899321211280668366426000006940370000058319012701015600188042811598150101001559000188057479171003413051365971180929541431219000000367076003861015077408002818048193204033940371006020023645070105000004000027000000000000000320000501005580900000000000000000050006233000000000000000180004004017605000000000000000062770000110000000018000000230000002302660130000000010000000092211000211107000000480140002500009130002290000000000210003
SPP62Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp62_202950000000000970024450000091800000010000000800000100000003235000004004000097801240490036000003100074020110000000000003310111000025000000013004003072700000183800000000000000200000015200002200330000532000000000000042000112030000000000000015776177158702872037962732639366031434826104654681411901297141267856435617241656000109978344310062267264211818216041106165877901637091739622290763861348447818830111406251823374291502121422820550819525100714391732086133211789109164390141841373462012105078341365111320756535641031143589157123438415202363586174238904870437702313568241389119320614079446160757787516102821380218214620692372282002121542281764004785872238394117994083796541813537204516653048016665024661470010290128411890726261547115149906862991128991732654142239109257858000147189742324372059603608551723400384105627434043131540411901053579
SPP8Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;multispecies_spp8_2007535100000024281059520032630071221150100000000910032022136123039000179013701137718600412810016000683213000005751001190731000001000013001401864150036000214002774176176002210001200026073900019747283114332419960000000078001203654240140340153000034910018000080001324469220001041472262008650000050002001084505983000000239006502814013107146200617800009300608005322007510000042701982135200406690798081125371129809633800294800050052000015001101600515210000321001081141200099380020200206771148930122310008140004510400081110051150013500000396057742400130107270199900020117263704810500135100072590000000101100029004002840995890100064240011808172185315
SPPN13Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_sppn13_2_nov_97.773%0000000060001000000000105000000600000000000000180300000000000001900300000000000900000000017000000000000000000000000010000000000021000003000000000000000070064500000000000120000000000000400000030002100000000005800000000000008970012515092780017280424209595598286003210005590510357800415000108013070451682872920045139000000001168009918656750004802361759716744233105009002750860302200185600083202110456252502610179259000000001183002214703170031701855376678174002180001640005000020200039088804920734827805570010000000962004224716770051033701231262101130184000950002510043400019108401827610105031219
SPPN20Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;multispecies_sppn20_2_nov_97.845%900160092000000000000000123000000003700010216901136228000000000610205627800790000000004900000103900011900010800193013838010352651000002200123011077000150000000003900000265300180000441037271631808700033038540000005001061180010311120082000000000240000029320005400013750707061720874954690000014200675000000000000000000000001000020000000000900700000000000007000000000000000000000007100000000000040000000000000431200000000000038000003600029000000003326007620000011000270021140010000000000220000000002800080060611008000000220002134
 
 
Download OTU Tables at Different Taxonomy Levels
PhylumCount*: Relative**: CLR***:
ClassCount*: Relative**: CLR***:
OrderCount*: Relative**: CLR***:
FamilyCount*: Relative**: CLR***:
GenusCount*: Relative**: CLR***:
SpeciesCount*: Relative**: CLR***:
* Read count
** Relative abundance (count/total sample count)
*** Centered log ratio transformed abundance
;
 
The species listed in the table has full taxonomy and a dynamically assigned species ID specific to this report. When some reads match with the reference sequences of more than one species equally (i.e., same percent identiy and alignmnet coverage), they can't be assigned to a particular species. Instead, they are assigned to multiple species with the species notaton "s__multispecies_spp2_2". In this notation, spp2 is the dynamic ID assigned to these reads that hit multiple sequences and the "_2" at the end of the notation means there are two species in the spp2.

You can look up which species are included in the multi-species assignment, in this table below:
 
 
 
 
Another type of notation is "s__multispecies_sppn2_2", in which the "n" in the sppn2 means it's a potential novel species because all the reads in this species have < 98% idenity to any of the reference sequences. They were grouped together based on de novo OTU clustering at 98% identity cutoff. And then a representative sequence was chosed to BLASTN search against the reference database to find the closest match (but will still be < 98%). This representative sequence also matched equally to more than one species, hence the "spp" was given in the label.
 
 

Taxonomy Bar Plots for All Samples

 
 

Taxonomy Bar Plots for Individual Comparison Groups

 
 
Comparison No.Comparison NameFamiliesGeneraSpecies
Comparison 1Product A V2 vs Product A V3PDFSVGPDFSVGPDFSVG
Comparison 2Product B V2 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 3Product A V2 vs Product B V2PDFSVGPDFSVGPDFSVG
Comparison 4Product A V3 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 5Product A V2 SAL vs Product A V3 SALPDFSVGPDFSVGPDFSVG
Comparison 6Product B V2 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 7Product A V2 SAL vs Product B V2 SALPDFSVGPDFSVGPDFSVG
Comparison 8Product A V3 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 9Product A V2 TNG vs Product A V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 10Product B V2 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 11Product A V2 TNG vs Product B V2 TNGPDFSVGPDFSVGPDFSVG
Comparison 12Product A V3 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 13Product A V2 SUPG vs Product A V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 14Product B V2 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 15Product A V2 SUPG vs Product B V2 SUPGPDFSVGPDFSVGPDFSVG
Comparison 16Product A V3 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 17Product A V2 SUBG vs Product A V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 18Product B V2 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 19Product A V2 SUBG vs Product B V2 SUBGPDFSVGPDFSVGPDFSVG
Comparison 20Product A V3 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
 
 

VIII. Analysis - Alpha Diversity

 

In ecology, alpha diversity (α-diversity) is the mean species diversity in sites or habitats at a local scale. The term was introduced by R. H. Whittaker[1][2] together with the terms beta diversity (β-diversity) and gamma diversity (γ-diversity). Whittaker's idea was that the total species diversity in a landscape (gamma diversity) is determined by two different things, the mean species diversity in sites or habitats at a more local scale (alpha diversity) and the differentiation among those habitats (beta diversity).


References:
Whittaker, R. H. (1960) Vegetation of the Siskiyou Mountains, Oregon and California. Ecological Monographs, 30, 279–338. doi:10.2307/1943563
Whittaker, R. H. (1972). Evolution and Measurement of Species Diversity. Taxon, 21, 213-251. doi:10.2307/1218190

 

Alpha Diversity Analysis by Rarefaction

Diversity measures are affected by the sampling depth. Rarefaction is a technique to assess species richness from the results of sampling. Rarefaction allows the calculation of species richness for a given number of individual samples, based on the construction of so-called rarefaction curves. This curve is a plot of the number of species as a function of the number of samples. Rarefaction curves generally grow rapidly at first, as the most common species are found, but the curves plateau as only the rarest species remain to be sampled.


References:
Willis AD. Rarefaction, Alpha Diversity, and Statistics. Front Microbiol. 2019 Oct 23;10:2407. doi: 10.3389/fmicb.2019.02407. PMID: 31708888; PMCID: PMC6819366.

 
 
 

Boxplot of Alpha-diversity Indices

The two main factors taken into account when measuring diversity are richness and evenness. Richness is a measure of the number of different kinds of organisms present in a particular area. Evenness compares the similarity of the population size of each of the species present. There are many different ways to measure the richness and evenness. These measurements are called "estimators" or "indices". Below is a diversity of 3 commonly used indices showing the values for all the samples (dots) and in groups (boxes).

 
Alpha Diversity Box Plots for All Groups
 
 
 
 
 
 
 
Alpha Diversity Box Plots for Individual Comparisons
 
Comparison 1Product A V2 vs Product A V3View in PDFView in SVG
Comparison 2Product B V2 vs Product B V3View in PDFView in SVG
Comparison 3Product A V2 vs Product B V2View in PDFView in SVG
Comparison 4Product A V3 vs Product B V3View in PDFView in SVG
Comparison 5Product A V2 SAL vs Product A V3 SALView in PDFView in SVG
Comparison 6Product B V2 SAL vs Product B V3 SALView in PDFView in SVG
Comparison 7Product A V2 SAL vs Product B V2 SALView in PDFView in SVG
Comparison 8Product A V3 SAL vs Product B V3 SALView in PDFView in SVG
Comparison 9Product A V2 TNG vs Product A V3 TNGView in PDFView in SVG
Comparison 10Product B V2 TNG vs Product B V3 TNGView in PDFView in SVG
Comparison 11Product A V2 TNG vs Product B V2 TNGView in PDFView in SVG
Comparison 12Product A V3 TNG vs Product B V3 TNGView in PDFView in SVG
Comparison 13Product A V2 SUPG vs Product A V3 SUPGView in PDFView in SVG
Comparison 14Product B V2 SUPG vs Product B V3 SUPGView in PDFView in SVG
Comparison 15Product A V2 SUPG vs Product B V2 SUPGView in PDFView in SVG
Comparison 16Product A V3 SUPG vs Product B V3 SUPGView in PDFView in SVG
Comparison 17Product A V2 SUBG vs Product A V3 SUBGView in PDFView in SVG
Comparison 18Product B V2 SUBG vs Product B V3 SUBGView in PDFView in SVG
Comparison 19Product A V2 SUBG vs Product B V2 SUBGView in PDFView in SVG
Comparison 20Product A V3 SUBG vs Product B V3 SUBGView in PDFView in SVG
 
 
 

Group Significance of Alpha-diversity Indices

To test whether the alpha diversity among different comparison groups are different statistically, we use the Kruskal Wallis H test provided the "alpha-group-significance" fucntion in the QIIME 2 "diversity" package. Kruskal Wallis H test is the non-parametric alternative to the One Way ANOVA. Non-parametric means that the test doesn’t assume your data comes from a particular distribution. The H test is used when the assumptions for ANOVA aren’t met (like the assumption of normality). It is sometimes called the one-way ANOVA on ranks, as the ranks of the data values are used in the test rather than the actual data points. The H test determines whether the medians of two or more groups are different.

Below are the Kruskal Wallis H test results for each comparison based on three different alpha diversity measures: 1) Observed species (features), 2) Shannon index, and 3) Simpson index.

 
 
Comparison 1.Product A V2 vs Product A V3Observed FeaturesShannon IndexSimpson Index
Comparison 2.Product B V2 vs Product B V3Observed FeaturesShannon IndexSimpson Index
Comparison 3.Product A V2 vs Product B V2Observed FeaturesShannon IndexSimpson Index
Comparison 4.Product A V3 vs Product B V3Observed FeaturesShannon IndexSimpson Index
Comparison 5.Product A V2 SAL vs Product A V3 SALObserved FeaturesShannon IndexSimpson Index
Comparison 6.Product B V2 SAL vs Product B V3 SALObserved FeaturesShannon IndexSimpson Index
Comparison 7.Product A V2 SAL vs Product B V2 SALObserved FeaturesShannon IndexSimpson Index
Comparison 8.Product A V3 SAL vs Product B V3 SALObserved FeaturesShannon IndexSimpson Index
Comparison 9.Product A V2 TNG vs Product A V3 TNGObserved FeaturesShannon IndexSimpson Index
Comparison 10.Product B V2 TNG vs Product B V3 TNGObserved FeaturesShannon IndexSimpson Index
Comparison 11.Product A V2 TNG vs Product B V2 TNGObserved FeaturesShannon IndexSimpson Index
Comparison 12.Product A V3 TNG vs Product B V3 TNGObserved FeaturesShannon IndexSimpson Index
Comparison 13.Product A V2 SUPG vs Product A V3 SUPGObserved FeaturesShannon IndexSimpson Index
Comparison 14.Product B V2 SUPG vs Product B V3 SUPGObserved FeaturesShannon IndexSimpson Index
Comparison 15.Product A V2 SUPG vs Product B V2 SUPGObserved FeaturesShannon IndexSimpson Index
Comparison 16.Product A V3 SUPG vs Product B V3 SUPGObserved FeaturesShannon IndexSimpson Index
Comparison 17.Product A V2 SUBG vs Product A V3 SUBGObserved FeaturesShannon IndexSimpson Index
Comparison 18.Product B V2 SUBG vs Product B V3 SUBGObserved FeaturesShannon IndexSimpson Index
Comparison 19.Product A V2 SUBG vs Product B V2 SUBGObserved FeaturesShannon IndexSimpson Index
Comparison 20.Product A V3 SUBG vs Product B V3 SUBGObserved FeaturesShannon IndexSimpson Index
 
 

IX. Analysis - Beta Diversity

 

NMDS and PCoA Plots

Beta diversity compares the similarity (or dissimilarity) of microbial profiles between different groups of samples. There are many different similarity/dissimilarity metrics. In general, they can be quantitative (using sequence abundance, e.g., Bray-Curtis or weighted UniFrac) or binary (considering only presence-absence of sequences, e.g., binary Jaccard or unweighted UniFrac). They can be even based on phylogeny (e.g., UniFrac metrics) or not (non-UniFrac metrics, such as Bray-Curtis, etc.).

For microbiome studies, species profiles of samples can be compared with the Bray-Curtis dissimilarity, which is based on the count data type. The pair-wise Bray-Curtis dissimilarity matrix of all samples can then be subject to either multi-dimensional scaling (MDS, also known as PCoA) or non-metric MDS (NMDS).

MDS/PCoA is a scaling or ordination method that starts with a matrix of similarities or dissimilarities between a set of samples and aims to produce a low-dimensional graphical plot of the data in such a way that distances between points in the plot are close to original dissimilarities.

NMDS is similar to MDS, however it does not use the dissimilarities data, instead it converts them into the ranks and use these ranks in the calculation.

In our beta diversity analysis, Bray-Curtis dissimilarity matrix was first calculated and then plotted by the PCoA and NMDS separately. Below are beta diveristy results for all groups together:

 
 
NMDS and PCoA Plots for All Groups
 
 
 
 
 

The above PCoA and NMDS plots are based on count data. The count data can also be transformed into centered log ratio (CLR) for each species. The CLR data is no longer count data and cannot be used in Bray-Curtis dissimilarity calculation. Instead CLR can be compared with Euclidean distances. When CLR data are compared by Euclidean distance, the distance is also called Aitchison distance.

Below are the NMDS and PCoA plots of the Aitchison distances of the samples:

 
 
 
 
 
 
 
NMDS and PCoA Plots for Individual Comparisons
 
 
Comparison No.Comparison NameNMDAPCoA
Bray-CurtisCLR EuclideanBray-CurtisCLR Euclidean
Comparison 1Product A V2 vs Product A V3PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 2Product B V2 vs Product B V3PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 3Product A V2 vs Product B V2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 4Product A V3 vs Product B V3PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 5Product A V2 SAL vs Product A V3 SALPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 6Product B V2 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 7Product A V2 SAL vs Product B V2 SALPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 8Product A V3 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 9Product A V2 TNG vs Product A V3 TNGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 10Product B V2 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 11Product A V2 TNG vs Product B V2 TNGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 12Product A V3 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 13Product A V2 SUPG vs Product A V3 SUPGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 14Product B V2 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 15Product A V2 SUPG vs Product B V2 SUPGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 16Product A V3 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 17Product A V2 SUBG vs Product A V3 SUBGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 18Product B V2 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 19Product A V2 SUBG vs Product B V2 SUBGPDFSVGPDFSVGPDFSVGPDFSVG
Comparison 20Product A V3 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVGPDFSVG
 
 
 
 
 

Interactive 3D PCoA Plots - Bray-Curtis Dissimilarity

 
 
 

Interactive 3D PCoA Plots - Euclidean Distance

 
 
 

Interactive 3D PCoA Plots - Correlation Coefficients

 
 
 

Group Significance of Beta-diversity Indices

To test whether the between-group dissimilarities are significantly greater than the within-group dissimilarities, the "beta-group-significance" function provided in the QIIME 2 "diversity" package was used with PERMANOVA (permutational multivariate analysis of variance) as the group significant testing method.

Three beta diversity matrics were used: 1) Bray–Curtis dissimilarity 2) Correlation coefficient matrix , and 3) Aitchison distance (Euclidean distance between clr-transformed compositions).

 
 
Comparison 1.Product A V2 vs Product A V3Bray–CurtisCorrelationAitchison
Comparison 2.Product B V2 vs Product B V3Bray–CurtisCorrelationAitchison
Comparison 3.Product A V2 vs Product B V2Bray–CurtisCorrelationAitchison
Comparison 4.Product A V3 vs Product B V3Bray–CurtisCorrelationAitchison
Comparison 5.Product A V2 SAL vs Product A V3 SALBray–CurtisCorrelationAitchison
Comparison 6.Product B V2 SAL vs Product B V3 SALBray–CurtisCorrelationAitchison
Comparison 7.Product A V2 SAL vs Product B V2 SALBray–CurtisCorrelationAitchison
Comparison 8.Product A V3 SAL vs Product B V3 SALBray–CurtisCorrelationAitchison
Comparison 9.Product A V2 TNG vs Product A V3 TNGBray–CurtisCorrelationAitchison
Comparison 10.Product B V2 TNG vs Product B V3 TNGBray–CurtisCorrelationAitchison
Comparison 11.Product A V2 TNG vs Product B V2 TNGBray–CurtisCorrelationAitchison
Comparison 12.Product A V3 TNG vs Product B V3 TNGBray–CurtisCorrelationAitchison
Comparison 13.Product A V2 SUPG vs Product A V3 SUPGBray–CurtisCorrelationAitchison
Comparison 14.Product B V2 SUPG vs Product B V3 SUPGBray–CurtisCorrelationAitchison
Comparison 15.Product A V2 SUPG vs Product B V2 SUPGBray–CurtisCorrelationAitchison
Comparison 16.Product A V3 SUPG vs Product B V3 SUPGBray–CurtisCorrelationAitchison
Comparison 17.Product A V2 SUBG vs Product A V3 SUBGBray–CurtisCorrelationAitchison
Comparison 18.Product B V2 SUBG vs Product B V3 SUBGBray–CurtisCorrelationAitchison
Comparison 19.Product A V2 SUBG vs Product B V2 SUBGBray–CurtisCorrelationAitchison
Comparison 20.Product A V3 SUBG vs Product B V3 SUBGBray–CurtisCorrelationAitchison
 
 
 

X. Analysis - Differential Abundance

16S rRNA next generation sequencing (NGS) generates a fixed number of reads that reflect the proportion of different species in a sample, i.e., the relative abundance of species, instead of the absolute abundance. In Mathematics, measurements involving probabilities, proportions, percentages, and ppm can all be thought of as compositional data. This makes the microbiome read count data “compositional” (Gloor et al, 2017). In general, compositional data represent parts of a whole which only carry relative information (http://www.compositionaldata.com/).

The problem of microbiome data being compositional arises when comparing two groups of samples for identifying “differentially abundant” species. A species with the same absolute abundance between two conditions, its relative abundances in the two conditions (e.g., percent abundance) can become different if the relative abundance of other species change greatly. This problem can lead to incorrect conclusion in terms of differential abundance for microbial species in the samples.

When studying differential abundance (DA), the current better approach is to transform the read count data into log ratio data. The ratios are calculated between read counts of all species in a sample to a “reference” count (e.g., mean read count of the sample). The log ratio data allow the detection of DA species without being affected by percentage bias mentioned above

In this report, a compositional DA analysis tool “ANCOM” (analysis of composition of microbiomes) was used. ANCOM transforms the count data into log-ratios and thus is more suitable for comparing the composition of microbiomes in two or more populations. "ANCOM" generates a table of features with W-statistics and whether the null hypothesis is rejected. The “W” is the W-statistic, or number of features that a single feature is tested to be significantly different against. Hence the higher the "W" the more statistical sifgnificant that a feature/species is differentially abundant.


References:

Gloor GB, Macklaim JM, Pawlowsky-Glahn V, Egozcue JJ. Microbiome Datasets Are Compositional: And This Is Not Optional. Front Microbiol. 2017 Nov 15;8:2224. doi: 10.3389/fmicb.2017.02224. PMID: 29187837; PMCID: PMC5695134.

Mandal S, Van Treuren W, White RA, Eggesbø M, Knight R, Peddada SD. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb Ecol Health Dis. 2015 May 29;26:27663. doi: 10.3402/mehd.v26.27663. PMID: 26028277; PMCID: PMC4450248.

Lin H, Peddada SD. Analysis of compositions of microbiomes with bias correction. Nat Commun. 2020 Jul 14;11(1):3514. doi: 10.1038/s41467-020-17041-7. PMID: 32665548; PMCID: PMC7360769.

 
 

ANCOM Differential Abundance Analysis

 
ANCOM Results for Individual Comparisons
Comparison No.Comparison Name
Comparison 1.Product A V2 vs Product A V3
Comparison 2.Product B V2 vs Product B V3
Comparison 3.Product A V2 vs Product B V2
Comparison 4.Product A V3 vs Product B V3
Comparison 5.Product A V2 SAL vs Product A V3 SAL
Comparison 6.Product B V2 SAL vs Product B V3 SAL
Comparison 7.Product A V2 SAL vs Product B V2 SAL
Comparison 8.Product A V3 SAL vs Product B V3 SAL
Comparison 9.Product A V2 TNG vs Product A V3 TNG
Comparison 10.Product B V2 TNG vs Product B V3 TNG
Comparison 11.Product A V2 TNG vs Product B V2 TNG
Comparison 12.Product A V3 TNG vs Product B V3 TNG
Comparison 13.Product A V2 SUPG vs Product A V3 SUPG
Comparison 14.Product B V2 SUPG vs Product B V3 SUPG
Comparison 15.Product A V2 SUPG vs Product B V2 SUPG
Comparison 16.Product A V3 SUPG vs Product B V3 SUPG
Comparison 17.Product A V2 SUBG vs Product A V3 SUBG
Comparison 18.Product B V2 SUBG vs Product B V3 SUBG
Comparison 19.Product A V2 SUBG vs Product B V2 SUBG
Comparison 20.Product A V3 SUBG vs Product B V3 SUBG
 
 

ANCOM-BC2 Differential Abundance Analysis

 

Starting with version V1.2, we include the results of ANCOM-BC (Analysis of Compositions of Microbiomes with Bias Correction) (Lin and Peddada 2020). ANCOM-BC is an updated version of "ANCOM" that:
(a) provides statistically valid test with appropriate p-values,
(b) provides confidence intervals for differential abundance of each taxon,
(c) controls the False Discovery Rate (FDR),
(d) maintains adequate power, and
(e) is computationally simple to implement.

The bias correction (BC) addresses a challenging problem of the bias introduced by differences in the sampling fractions across samples. This bias has been a major hurdle in performing DA analysis of microbiome data. ANCOM-BC estimates the unknown sampling fractions and corrects the bias induced by their differences among samples. The absolute abundance data are modeled using a linear regression framework.

Starting with version V1.43, ANCOM-BC2 is used instead of ANCOM-BC, So that multiple pairwise directional test can be performed (if there are more than two gorups in a comparison). When performing pairwise directional test, the mixed directional false discover rate (mdFDR) is taken into account. The mdFDR is the combination of false discovery rate due to multiple testing, multiple pairwise comparisons, and directional tests within each pairwise comparison. The mdFDR is adopted from (Guo, Sarkar, and Peddada 2010; Grandhi, Guo, and Peddada 2016). For more detail explanation and additional features of ANCOM-BC2 please see author's documentation.

References:

Lin H, Peddada SD. Analysis of compositions of microbiomes with bias correction. Nat Commun. 2020 Jul 14;11(1):3514. doi: 10.1038/s41467-020-17041-7. PMID: 32665548; PMCID: PMC7360769.

Guo W, Sarkar SK, Peddada SD. Controlling false discoveries in multidimensional directional decisions, with applications to gene expression data on ordered categories. Biometrics. 2010 Jun;66(2):485-92. doi: 10.1111/j.1541-0420.2009.01292.x. Epub 2009 Jul 23. PMID: 19645703; PMCID: PMC2895927.

Grandhi A, Guo W, Peddada SD. A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies. BMC Bioinformatics. 2016 Feb 25;17:104. doi: 10.1186/s12859-016-0937-5. PMID: 26917217; PMCID: PMC4768411.

 
 
ANCOM-BC Results for Individual Comparisons
 
Comparison No.Comparison Name
Comparison 1.Product A V2 vs Product A V3
Comparison 2.Product B V2 vs Product B V3
Comparison 3.Product A V2 vs Product B V2
Comparison 4.Product A V3 vs Product B V3
Comparison 5.Product A V2 SAL vs Product A V3 SAL
Comparison 6.Product B V2 SAL vs Product B V3 SAL
Comparison 7.Product A V2 SAL vs Product B V2 SAL
Comparison 8.Product A V3 SAL vs Product B V3 SAL
Comparison 9.Product A V2 TNG vs Product A V3 TNG
Comparison 10.Product B V2 TNG vs Product B V3 TNG
Comparison 11.Product A V2 TNG vs Product B V2 TNG
Comparison 12.Product A V3 TNG vs Product B V3 TNG
Comparison 13.Product A V2 SUPG vs Product A V3 SUPG
Comparison 14.Product B V2 SUPG vs Product B V3 SUPG
Comparison 15.Product A V2 SUPG vs Product B V2 SUPG
Comparison 16.Product A V3 SUPG vs Product B V3 SUPG
Comparison 17.Product A V2 SUBG vs Product A V3 SUBG
Comparison 18.Product B V2 SUBG vs Product B V3 SUBG
Comparison 19.Product A V2 SUBG vs Product B V2 SUBG
Comparison 20.Product A V3 SUBG vs Product B V3 SUBG
 
 
 

LEfSe - Linear Discriminant Analysis Effect Size

LEfSe (Linear Discriminant Analysis Effect Size) is an alternative method to find "organisms, genes, or pathways that consistently explain the differences between two or more microbial communities" (Segata et al., 2011). Specifically, LEfSe uses rank-based Kruskal-Wallis (KW) sum-rank test to detect features with significant differential (relative) abundance with respect to the class of interest. Since it is rank-based, instead of proportional based, the differential species identified among the comparison groups is less biased (than percent abundance based).

Reference:

Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C. Metagenomic biomarker discovery and explanation. Genome Biol. 2011 Jun 24;12(6):R60. doi: 10.1186/gb-2011-12-6-r60. PMID: 21702898; PMCID: PMC3218848.

 
Product A V2 vs Product A V3
 
 
 
 
 
 
 
LEfSe Results for All Comparisons
 
Comparison No.Comparison Name
Comparison 1.Product A V2 vs Product A V3
Comparison 2.Product B V2 vs Product B V3
Comparison 3.Product A V2 vs Product B V2
Comparison 4.Product A V3 vs Product B V3
Comparison 5.Product A V2 SAL vs Product A V3 SAL
Comparison 6.Product B V2 SAL vs Product B V3 SAL
Comparison 7.Product A V2 SAL vs Product B V2 SAL
Comparison 8.Product A V3 SAL vs Product B V3 SAL
Comparison 9.Product A V2 TNG vs Product A V3 TNG
Comparison 10.Product B V2 TNG vs Product B V3 TNG
Comparison 11.Product A V2 TNG vs Product B V2 TNG
Comparison 12.Product A V3 TNG vs Product B V3 TNG
Comparison 13.Product A V2 SUPG vs Product A V3 SUPG
Comparison 14.Product B V2 SUPG vs Product B V3 SUPG
Comparison 15.Product A V2 SUPG vs Product B V2 SUPG
Comparison 16.Product A V3 SUPG vs Product B V3 SUPG
Comparison 17.Product A V2 SUBG vs Product A V3 SUBG
Comparison 18.Product B V2 SUBG vs Product B V3 SUBG
Comparison 19.Product A V2 SUBG vs Product B V2 SUBG
Comparison 20.Product A V3 SUBG vs Product B V3 SUBG
 
 

XI. Analysis - Heatmap Profile

 

Species vs Sample Abundance Heatmap for All Samples

 
 
 

Heatmaps for Individual Comparisons

 
A) Two-way clustering - clustered on both columns (Samples) and rows (organism)
Comparison No.Comparison NameFamily LevelGenus LevelSpecies Level
Comparison 1Product A V2 vs Product A V3PDFSVGPDFSVGPDFSVG
Comparison 2Product B V2 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 3Product A V2 vs Product B V2PDFSVGPDFSVGPDFSVG
Comparison 4Product A V3 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 5Product A V2 SAL vs Product A V3 SALPDFSVGPDFSVGPDFSVG
Comparison 6Product B V2 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 7Product A V2 SAL vs Product B V2 SALPDFSVGPDFSVGPDFSVG
Comparison 8Product A V3 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 9Product A V2 TNG vs Product A V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 10Product B V2 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 11Product A V2 TNG vs Product B V2 TNGPDFSVGPDFSVGPDFSVG
Comparison 12Product A V3 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 13Product A V2 SUPG vs Product A V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 14Product B V2 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 15Product A V2 SUPG vs Product B V2 SUPGPDFSVGPDFSVGPDFSVG
Comparison 16Product A V3 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 17Product A V2 SUBG vs Product A V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 18Product B V2 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 19Product A V2 SUBG vs Product B V2 SUBGPDFSVGPDFSVGPDFSVG
Comparison 20Product A V3 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
 
 
B) One-way clustering - clustered on rows (organism) only
Comparison No.Comparison NameFamily LevelGenus LevelSpecies Level
Comparison 1Product A V2 vs Product A V3PDFSVGPDFSVGPDFSVG
Comparison 2Product B V2 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 3Product A V2 vs Product B V2PDFSVGPDFSVGPDFSVG
Comparison 4Product A V3 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 5Product A V2 SAL vs Product A V3 SALPDFSVGPDFSVGPDFSVG
Comparison 6Product B V2 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 7Product A V2 SAL vs Product B V2 SALPDFSVGPDFSVGPDFSVG
Comparison 8Product A V3 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 9Product A V2 TNG vs Product A V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 10Product B V2 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 11Product A V2 TNG vs Product B V2 TNGPDFSVGPDFSVGPDFSVG
Comparison 12Product A V3 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 13Product A V2 SUPG vs Product A V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 14Product B V2 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 15Product A V2 SUPG vs Product B V2 SUPGPDFSVGPDFSVGPDFSVG
Comparison 16Product A V3 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 17Product A V2 SUBG vs Product A V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 18Product B V2 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 19Product A V2 SUBG vs Product B V2 SUBGPDFSVGPDFSVGPDFSVG
Comparison 20Product A V3 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
 
 
C) No clustering
Comparison No.Comparison NameFamily LevelGenus LevelSpecies Level
Comparison 1Product A V2 vs Product A V3PDFSVGPDFSVGPDFSVG
Comparison 2Product B V2 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 3Product A V2 vs Product B V2PDFSVGPDFSVGPDFSVG
Comparison 4Product A V3 vs Product B V3PDFSVGPDFSVGPDFSVG
Comparison 5Product A V2 SAL vs Product A V3 SALPDFSVGPDFSVGPDFSVG
Comparison 6Product B V2 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 7Product A V2 SAL vs Product B V2 SALPDFSVGPDFSVGPDFSVG
Comparison 8Product A V3 SAL vs Product B V3 SALPDFSVGPDFSVGPDFSVG
Comparison 9Product A V2 TNG vs Product A V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 10Product B V2 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 11Product A V2 TNG vs Product B V2 TNGPDFSVGPDFSVGPDFSVG
Comparison 12Product A V3 TNG vs Product B V3 TNGPDFSVGPDFSVGPDFSVG
Comparison 13Product A V2 SUPG vs Product A V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 14Product B V2 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 15Product A V2 SUPG vs Product B V2 SUPGPDFSVGPDFSVGPDFSVG
Comparison 16Product A V3 SUPG vs Product B V3 SUPGPDFSVGPDFSVGPDFSVG
Comparison 17Product A V2 SUBG vs Product A V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 18Product B V2 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
Comparison 19Product A V2 SUBG vs Product B V2 SUBGPDFSVGPDFSVGPDFSVG
Comparison 20Product A V3 SUBG vs Product B V3 SUBGPDFSVGPDFSVGPDFSVG
 
 

XII. Analysis - Network Association

To analyze the co-occurrence or co-exclusion between microbial species among different samples, network correlation analysis tools are usually used for this purpose. However, microbiome count data are compositional. If count data are normalized to the total number of counts in the sample, the data become not independent and traditional statistical metrics (e.g., correlation) for the detection of specie-species relationships can lead to spurious results. In addition, sequencing-based studies typically measure hundreds of OTUs (species) on few samples; thus, inference of OTU-OTU association networks is severely under-powered. Here we use SPIEC-EASI (SParse InversE Covariance Estimation for Ecological Association Inference), a statistical method for the inference of microbial ecological networks from amplicon sequencing datasets that addresses both of these issues (Kurtz et al., 2015). SPIEC-EASI combines data transformations developed for compositional data analysis with a graphical model inference framework that assumes the underlying ecological association network is sparse. SPIEC-EASI provides two algorithms for network inferencing – 1) Meinshausen-Bühlmann's neighborhood selection (MB method) and inverse covariance selection (GLASSO method, i.e., graphical least absolute shrinkage and selection operator). This is fundamentally distinct from SparCC, which essentially estimate pairwise correlations. In addition to these two methods, we provide the results of a third method - SparCC (Sparse Correlations for Compositional Data)(Friedman & Alm 2012), which is also a method for inferring correlations from compositional data. SparCC estimates the linear Pearson correlations between the log-transformed components.


References:

Kurtz ZD, Müller CL, Miraldi ER, Littman DR, Blaser MJ, Bonneau RA. Sparse and compositionally robust inference of microbial ecological networks. PLoS Comput Biol. 2015 May 7;11(5):e1004226. doi: 10.1371/journal.pcbi.1004226. PMID: 25950956; PMCID: PMC4423992.

Friedman J, Alm EJ. Inferring correlation networks from genomic survey data. PLoS Comput Biol. 2012;8(9):e1002687. doi: 10.1371/journal.pcbi.1002687. Epub 2012 Sep 20. PMID: 23028285; PMCID: PMC3447976.

 

SPIEC-EASI Network Inference by Neighborhood Selection (MB Method)

 
 

 

Association Network Inference by SparCC

 
 

 
 

XIII. Disclaimer

The results of this analysis are for research purpose only. They are not intended to diagnose, treat, cure, or prevent any disease. Forsyth and FOMC are not responsible for use of information provided in this report outside the research area.

 
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