Table of Content
I.Project Summary
II.Workflow Checklist
III.NGS Sequencing Results
IV.Complete Report Download
V.Raw Sequence Data Download
VI.Analysis - DADA2 Read Processing
 Sample Meta Info
 Read Count by Sample
VII.Analysis - Read Taxonomy Assignment
 Taxonomy Barplots
VIII.Analysis - Alpha Diversity
IX.Analysis - Beta Diversity
X.Analysis - Differential Abundance
 ANCOM Result
 LEfSe Result
XI.Analysis - Heatmap Profile
XII.Analysis - Network Association

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FOMC Service Report

16S rRNA Gene V1V3 Amplicon Sequencing

Version V1.41

Version History

The Forsyth Institute, Cambridge, MA, USA
September 30, 2022

Project ID: FOMC5677_Subgroup_P2_1

I. Project Summary

Project FOMC5677_Subgroup_P2_1 services include NGS sequencing of the V1V3 region of the 16S rRNA amplicons from the samples. First and foremost, please download this report, as well as the sequence raw data from the download links provided below. These links will expire after 60 days. We cannot guarantee the availability of your data after 60 days.

Full Bioinformatics analysis service was requested. We provide many analyses, starting from the raw sequence quality and noise filtering, pair reads merging, as well as chimera filtering for the sequences, using the DADA2 denosing algorithm and pipeline.

We also provide many downstream analyses such as taxonomy assignment, alpha and beta diversity analyses, and differential abundance analysis.

For taxonomy assignment, most informative would be the taxonomy barplots. We provide an interactive barplots to show the relative abundance of microbes at different taxonomy levels (from Phylum to species) that you can choose.

If you specify which groups of samples you want to compare for differential abundance, we provide both ANCOM and LEfSe differential abundance analysis.

 

II. Workflow Checklist

☑1.Sample Received
☑2.Sample Quality Evaluated
☑3.Sample Prepared for Sequencing
☑4.Next-Gen Sequencing
☑5.Sequence Quality Check
☑6.Absolute Abundance
☑7.Report and Raw Sequence Data Available for Download
☑8.Bioinformatics Analysis - Reads Processing (DADA2 Quality Trimming, Denoising, Paired Reads Merging)
☑9.Bioinformatics Analysis - Reads Taxonomy Assignment
☑10.Bioinformatics Analysis - Alpha Diversity Analysis
☑11.Bioinformatics Analysis - Beta Diversity Analysis
☑12.Bioinformatics Analysis - Differential Abundance Analysis
☑13.Bioinformatics Analysis - Heatmap Profile
☑14.Bioinformatics Analysis - Network Association
 

III. NGS Sequencing

The samples were processed and analyzed with the ZymoBIOMICS® Service: Targeted Metagenomic Sequencing (Zymo Research, Irvine, CA).

DNA Extraction: If DNA extraction was performed, one of three different DNA extraction kits was used depending on the sample type and sample volume and were used according to the manufacturer’s instructions, unless otherwise stated. The kit used in this project is marked below:

☐ZymoBIOMICS® DNA Miniprep Kit (Zymo Research, Irvine, CA)
☐ZymoBIOMICS® DNA Microprep Kit (Zymo Research, Irvine, CA)
☐ZymoBIOMICS®-96 MagBead DNA Kit (Zymo Research, Irvine, CA)
☑N/A (DNA Extraction Not Performed)
Elution Volume: 50µL
Additional Notes: NA

Targeted Library Preparation: The DNA samples were prepared for targeted sequencing with the Quick-16S™ NGS Library Prep Kit (Zymo Research, Irvine, CA). These primers were custom designed by Zymo Research to provide the best coverage of the 16S gene while maintaining high sensitivity. The primer sets used in this project are marked below:

☐Quick-16S™ Primer Set V1-V2 (Zymo Research, Irvine, CA)
☑Quick-16S™ Primer Set V1-V3 (Zymo Research, Irvine, CA)
☐Quick-16S™ Primer Set V3-V4 (Zymo Research, Irvine, CA)
☐Quick-16S™ Primer Set V4 (Zymo Research, Irvine, CA)
☐Quick-16S™ Primer Set V6-V8 (Zymo Research, Irvine, CA)
☐Other: NA
Additional Notes: NA

The sequencing library was prepared using an innovative library preparation process in which PCR reactions were performed in real-time PCR machines to control cycles and therefore limit PCR chimera formation. The final PCR products were quantified with qPCR fluorescence readings and pooled together based on equal molarity. The final pooled library was cleaned up with the Select-a-Size DNA Clean & Concentrator™ (Zymo Research, Irvine, CA), then quantified with TapeStation® (Agilent Technologies, Santa Clara, CA) and Qubit® (Thermo Fisher Scientific, Waltham, WA).

Control Samples: The ZymoBIOMICS® Microbial Community Standard (Zymo Research, Irvine, CA) was used as a positive control for each DNA extraction, if performed. The ZymoBIOMICS® Microbial Community DNA Standard (Zymo Research, Irvine, CA) was used as a positive control for each targeted library preparation. Negative controls (i.e. blank extraction control, blank library preparation control) were included to assess the level of bioburden carried by the wet-lab process.

Sequencing: The final library was sequenced on Illumina® MiSeq™ with a V3 reagent kit (600 cycles). The sequencing was performed with 10% PhiX spike-in.

 

IV. Complete Report Download

The complete report of your project, including all links in this report, can be downloaded by clicking the link provided below. The downloaded file is a compressed ZIP file and once unzipped, open the file “REPORT.html” (may only shown as "REPORT" in your computer) by double clicking it. Your default web browser will open it and you will see the exact content of this report.

Please download and save the file to your computer storage device. The download link will expire after 60 days upon your receiving of this report.

Complete report download link:

To view the report, please follow the following steps:
1.Download the .zip file from the report link above.
2.Extract all the contents of the downloaded .zip file to your desktop.
3.Open the extracted folder and find the "REPORT.html" (may shown as only "REPORT").
4.Open (double-clicking) the REPORT.html file. Your default browser will open the top age of the complete report. Within the report, there are links to view all the analyses performed for the project.

 

V. Raw Sequence Data Download

The raw NGS sequence data is available for download with the link provided below. The data is a compressed ZIP file and can be unzipped to individual sequence files. Since this is a pair-end sequencing, each of your samples is represented by two sequence files, one for READ 1, with the file extension “*_R1.fastq.gz”, another READ 2, with the file extension “*_R1.fastq.gz”. The files are in FASTQ format and are compressed. FASTQ format is a text-based data format for storing both a biological sequence and its corresponding quality scores. Most sequence analysis software will be able to open them. The Sample IDs associated with the R1 and R2 fastq files are listed in the table below:



Sample IDOriginal Sample IDRead 1 File NameRead 2 File Name


F5677.S001Visit 3 Subject 26001 Plaque 1 of 2zr5677_100V1V3_R1.fastq.gzzr5677_100V1V3_R2.fastq.gz


F5677.S002Visit 3 Subject 26002 Plaque 1 of 2zr5677_101V1V3_R1.fastq.gzzr5677_101V1V3_R2.fastq.gz


F5677.S003Visit 3 Subject 26003 Plaque 1 of 2zr5677_102V1V3_R1.fastq.gzzr5677_102V1V3_R2.fastq.gz


F5677.S004Visit 3 Subject 26004 Plaque 1 of 2zr5677_103V1V3_R1.fastq.gzzr5677_103V1V3_R2.fastq.gz


F5677.S005Visit 3 Subject 26005 Plaque 1 of 2zr5677_104V1V3_R1.fastq.gzzr5677_104V1V3_R2.fastq.gz


F5677.S006Visit 3 Subject 26006 Plaque 1 of 2zr5677_105V1V3_R1.fastq.gzzr5677_105V1V3_R2.fastq.gz


F5677.S007Visit 3 Subject 26007 Plaque 1 of 2zr5677_106V1V3_R1.fastq.gzzr5677_106V1V3_R2.fastq.gz


F5677.S008Visit 3 Subject 26008 Plaque 1 of 2zr5677_107V1V3_R1.fastq.gzzr5677_107V1V3_R2.fastq.gz


F5677.S009Visit 3 Subject 26009 Plaque 1 of 2zr5677_108V1V3_R1.fastq.gzzr5677_108V1V3_R2.fastq.gz


F5677.S010Visit 3 Subject 26010 Plaque 1 of 2zr5677_109V1V3_R1.fastq.gzzr5677_109V1V3_R2.fastq.gz


F5677.S011Visit 3 Subject 26011 Plaque 1 of 2zr5677_10V1V3_R1.fastq.gzzr5677_10V1V3_R2.fastq.gz


F5677.S012Visit 3 Subject 26012 Plaque 1 of 2zr5677_110V1V3_R1.fastq.gzzr5677_110V1V3_R2.fastq.gz


F5677.S013Visit 3 Subject 26013 Plaque 1 of 2zr5677_111V1V3_R1.fastq.gzzr5677_111V1V3_R2.fastq.gz


F5677.S014Visit 3 Subject 26014 Plaque 1 of 2zr5677_112V1V3_R1.fastq.gzzr5677_112V1V3_R2.fastq.gz


F5677.S015Visit 3 Subject 26015 Plaque 1 of 2zr5677_113V1V3_R1.fastq.gzzr5677_113V1V3_R2.fastq.gz


F5677.S016Visit 3 Subject 26016 Plaque 1 of 2zr5677_114V1V3_R1.fastq.gzzr5677_114V1V3_R2.fastq.gz


F5677.S017Visit 3 Subject 26017 Plaque 1 of 2zr5677_115V1V3_R1.fastq.gzzr5677_115V1V3_R2.fastq.gz


F5677.S018Visit 3 Subject 26018 Plaque 1 of 2zr5677_116V1V3_R1.fastq.gzzr5677_116V1V3_R2.fastq.gz


F5677.S019Visit 3 Subject 26019 Plaque 1 of 2zr5677_117V1V3_R1.fastq.gzzr5677_117V1V3_R2.fastq.gz


F5677.S020Visit 3 Subject 26020 Plaque 1 of 2zr5677_118V1V3_R1.fastq.gzzr5677_118V1V3_R2.fastq.gz


F5677.S021Visit 3 Subject 26021 Plaque 1 of 2zr5677_119V1V3_R1.fastq.gzzr5677_119V1V3_R2.fastq.gz


F5677.S022Visit 3 Subject 26022 Plaque 1 of 2zr5677_11V1V3_R1.fastq.gzzr5677_11V1V3_R2.fastq.gz


F5677.S023Visit 3 Subject 26023 Plaque 1 of 2zr5677_120V1V3_R1.fastq.gzzr5677_120V1V3_R2.fastq.gz


F5677.S024Visit 3 Subject 26024 Plaque 1 of 2zr5677_121V1V3_R1.fastq.gzzr5677_121V1V3_R2.fastq.gz


F5677.S025Visit 3 Subject 26027 Plaque 1 of 2zr5677_122V1V3_R1.fastq.gzzr5677_122V1V3_R2.fastq.gz


F5677.S026Visit 3 Subject 26028 Plaque 1 of 2zr5677_123V1V3_R1.fastq.gzzr5677_123V1V3_R2.fastq.gz


F5677.S027Visit 3 Subject 26029 Plaque 1 of 2zr5677_124V1V3_R1.fastq.gzzr5677_124V1V3_R2.fastq.gz


F5677.S028Visit 3 Subject 26030 Plaque 1 of 2zr5677_125V1V3_R1.fastq.gzzr5677_125V1V3_R2.fastq.gz


F5677.S029Visit 3 Subject 26031 Plaque 1 of 2zr5677_126V1V3_R1.fastq.gzzr5677_126V1V3_R2.fastq.gz


F5677.S030Visit 3 Subject 26032 Plaque 1 of 2zr5677_127V1V3_R1.fastq.gzzr5677_127V1V3_R2.fastq.gz


F5677.S031Visit 3 Subject 26033 Plaque 1 of 2zr5677_128V1V3_R1.fastq.gzzr5677_128V1V3_R2.fastq.gz


F5677.S032Visit 3 Subject 26034 Plaque 1 of 2zr5677_129V1V3_R1.fastq.gzzr5677_129V1V3_R2.fastq.gz


F5677.S033Visit 3 Subject 26035 Plaque 1 of 2zr5677_12V1V3_R1.fastq.gzzr5677_12V1V3_R2.fastq.gz


F5677.S034Visit 3 Subject 26036 Plaque 1 of 2zr5677_130V1V3_R1.fastq.gzzr5677_130V1V3_R2.fastq.gz


F5677.S035Visit 3 Subject 26037 Plaque 1 of 2zr5677_131V1V3_R1.fastq.gzzr5677_131V1V3_R2.fastq.gz


F5677.S036Visit 3 Subject 26038 Plaque 1 of 2zr5677_132V1V3_R1.fastq.gzzr5677_132V1V3_R2.fastq.gz


F5677.S037Visit 3 Subject 26039 Plaque 1 of 2zr5677_133V1V3_R1.fastq.gzzr5677_133V1V3_R2.fastq.gz


F5677.S038Visit 3 Subject 26040 Plaque 1 of 2zr5677_134V1V3_R1.fastq.gzzr5677_134V1V3_R2.fastq.gz


F5677.S039Visit 3 Subject 26042 Plaque 1 of 2zr5677_135V1V3_R1.fastq.gzzr5677_135V1V3_R2.fastq.gz


F5677.S040Visit 3 Subject 26043 Plaque 1 of 2zr5677_136V1V3_R1.fastq.gzzr5677_136V1V3_R2.fastq.gz


F5677.S041Visit 3 Subject 26044 Plaque 1 of 2zr5677_137V1V3_R1.fastq.gzzr5677_137V1V3_R2.fastq.gz


F5677.S042Visit 3 Subject 26045 Plaque 1 of 2zr5677_138V1V3_R1.fastq.gzzr5677_138V1V3_R2.fastq.gz


F5677.S043Visit 3 Subject 26046 Plaque 1 of 2zr5677_139V1V3_R1.fastq.gzzr5677_139V1V3_R2.fastq.gz


F5677.S044Visit 3 Subject 26047 Plaque 1 of 2zr5677_13V1V3_R1.fastq.gzzr5677_13V1V3_R2.fastq.gz


F5677.S045Visit 3 Subject 26048 Plaque 1 of 2zr5677_140V1V3_R1.fastq.gzzr5677_140V1V3_R2.fastq.gz


F5677.S046Visit 3 Subject 26050 Plaque 1 of 2zr5677_141V1V3_R1.fastq.gzzr5677_141V1V3_R2.fastq.gz


F5677.S047Visit 3 Subject 26052 Plaque 1 of 2zr5677_142V1V3_R1.fastq.gzzr5677_142V1V3_R2.fastq.gz


F5677.S048Visit 3 Subject 26054 Plaque 1 of 2zr5677_143V1V3_R1.fastq.gzzr5677_143V1V3_R2.fastq.gz


F5677.S049Visit 3 Subject 26055 Plaque 1 of 2zr5677_144V1V3_R1.fastq.gzzr5677_144V1V3_R2.fastq.gz


F5677.S050Visit 3 Subject 26056 Plaque 1 of 2zr5677_145V1V3_R1.fastq.gzzr5677_145V1V3_R2.fastq.gz


F5677.S051Visit 3 Subject 26057 Plaque 1 of 2zr5677_146V1V3_R1.fastq.gzzr5677_146V1V3_R2.fastq.gz


F5677.S052Visit 3 Subject 26058 Plaque 1 of 2zr5677_147V1V3_R1.fastq.gzzr5677_147V1V3_R2.fastq.gz


F5677.S053Visit 3 Subject 26059 Plaque 1 of 2zr5677_148V1V3_R1.fastq.gzzr5677_148V1V3_R2.fastq.gz


F5677.S054Visit 3 Subject 26061 Plaque 1 of 2zr5677_149V1V3_R1.fastq.gzzr5677_149V1V3_R2.fastq.gz


F5677.S055Visit 3 Subject 26062 Plaque 1 of 2zr5677_14V1V3_R1.fastq.gzzr5677_14V1V3_R2.fastq.gz


F5677.S056Visit 3 Subject 26063 Plaque 1 of 2zr5677_150V1V3_R1.fastq.gzzr5677_150V1V3_R2.fastq.gz


F5677.S057Visit 3 Subject 26064 Plaque 1 of 2zr5677_151V1V3_R1.fastq.gzzr5677_151V1V3_R2.fastq.gz


F5677.S058Visit 3 Subject 26065 Plaque 1 of 2zr5677_152V1V3_R1.fastq.gzzr5677_152V1V3_R2.fastq.gz


F5677.S059Visit 3 Subject 26066 Plaque 1 of 2zr5677_153V1V3_R1.fastq.gzzr5677_153V1V3_R2.fastq.gz


F5677.S060Visit 3 Subject 26067 Plaque 1 of 2zr5677_154V1V3_R1.fastq.gzzr5677_154V1V3_R2.fastq.gz


F5677.S061Visit 3 Subject 26068 Plaque 1 of 2zr5677_155V1V3_R1.fastq.gzzr5677_155V1V3_R2.fastq.gz


F5677.S062Visit 3 Subject 26070 Plaque 1 of 2zr5677_156V1V3_R1.fastq.gzzr5677_156V1V3_R2.fastq.gz


F5677.S063Visit 3 Subject 26071 Plaque 1 of 2zr5677_157V1V3_R1.fastq.gzzr5677_157V1V3_R2.fastq.gz


F5677.S064Visit 3 Subject 26072 Plaque 1 of 2zr5677_158V1V3_R1.fastq.gzzr5677_158V1V3_R2.fastq.gz


F5677.S065Visit 3 Subject 26073 Plaque 1 of 2zr5677_159V1V3_R1.fastq.gzzr5677_159V1V3_R2.fastq.gz


F5677.S066Visit 3 Subject 26075 Plaque 1 of 2zr5677_15V1V3_R1.fastq.gzzr5677_15V1V3_R2.fastq.gz


F5677.S067Visit 3 Subject 26076 Plaque 1 of 2zr5677_160V1V3_R1.fastq.gzzr5677_160V1V3_R2.fastq.gz


F5677.S068Visit 3 Subject 26077 Plaque 1 of 2zr5677_161V1V3_R1.fastq.gzzr5677_161V1V3_R2.fastq.gz


F5677.S069Visit 3 Subject 26078 Plaque 1 of 2zr5677_162V1V3_R1.fastq.gzzr5677_162V1V3_R2.fastq.gz


F5677.S070Visit 3 Subject 26079 Plaque 1 of 2zr5677_163V1V3_R1.fastq.gzzr5677_163V1V3_R2.fastq.gz


F5677.S071Visit 3 Subject 26080 Plaque 1 of 2zr5677_164V1V3_R1.fastq.gzzr5677_164V1V3_R2.fastq.gz


F5677.S072Visit 3 Subject 26081 Plaque 1 of 2zr5677_165V1V3_R1.fastq.gzzr5677_165V1V3_R2.fastq.gz


F5677.S073Visit 3 Subject 26082 Plaque 1 of 2zr5677_166V1V3_R1.fastq.gzzr5677_166V1V3_R2.fastq.gz


F5677.S074Visit 3 Subject 26083 Plaque 1 of 2zr5677_167V1V3_R1.fastq.gzzr5677_167V1V3_R2.fastq.gz


F5677.S075Visit 3 Subject 26084 Plaque 1 of 2zr5677_168V1V3_R1.fastq.gzzr5677_168V1V3_R2.fastq.gz


F5677.S076Visit 3 Subject 26085 Plaque 1 of 2zr5677_169V1V3_R1.fastq.gzzr5677_169V1V3_R2.fastq.gz


F5677.S077Visit 3 Subject 26086 Plaque 1 of 2zr5677_16V1V3_R1.fastq.gzzr5677_16V1V3_R2.fastq.gz


F5677.S078Visit 3 Subject 26087 Plaque 1 of 2zr5677_170V1V3_R1.fastq.gzzr5677_170V1V3_R2.fastq.gz


F5677.S079Visit 3 Subject 26088 Plaque 1 of 2zr5677_171V1V3_R1.fastq.gzzr5677_171V1V3_R2.fastq.gz


F5677.S080Visit 3 Subject 26089 Plaque 1 of 2zr5677_172V1V3_R1.fastq.gzzr5677_172V1V3_R2.fastq.gz


F5677.S081Visit 3 Subject 26090 Plaque 1 of 2zr5677_173V1V3_R1.fastq.gzzr5677_173V1V3_R2.fastq.gz


F5677.S082Visit 3 Subject 26091 Plaque 1 of 2zr5677_174V1V3_R1.fastq.gzzr5677_174V1V3_R2.fastq.gz


F5677.S083Visit 3 Subject 26092 Plaque 1 of 2zr5677_175V1V3_R1.fastq.gzzr5677_175V1V3_R2.fastq.gz


F5677.S084Visit 3 Subject 26093 Plaque 1 of 2zr5677_176V1V3_R1.fastq.gzzr5677_176V1V3_R2.fastq.gz


F5677.S085Visit 3 Subject 26094 Plaque 1 of 2zr5677_177V1V3_R1.fastq.gzzr5677_177V1V3_R2.fastq.gz


F5677.S086Visit 3 Subject 26095 Plaque 1 of 2zr5677_178V1V3_R1.fastq.gzzr5677_178V1V3_R2.fastq.gz


F5677.S087Visit 3 Subject 26096 Plaque 1 of 2zr5677_179V1V3_R1.fastq.gzzr5677_179V1V3_R2.fastq.gz


F5677.S088Visit 3 Subject 26097 Plaque 1 of 2zr5677_17V1V3_R1.fastq.gzzr5677_17V1V3_R2.fastq.gz


F5677.S089Visit 3 Subject 26098 Plaque 1 of 2zr5677_180V1V3_R1.fastq.gzzr5677_180V1V3_R2.fastq.gz


F5677.S090Visit 3 Subject 26099 Plaque 1 of 2zr5677_181V1V3_R1.fastq.gzzr5677_181V1V3_R2.fastq.gz


F5677.S091Visit 3 Subject 26100 Plaque 1 of 2zr5677_182V1V3_R1.fastq.gzzr5677_182V1V3_R2.fastq.gz


F5677.S092Visit 3 Subject 26101 Plaque 1 of 2zr5677_183V1V3_R1.fastq.gzzr5677_183V1V3_R2.fastq.gz


F5677.S093Visit 3 Subject 26102 Plaque 1 of 2zr5677_184V1V3_R1.fastq.gzzr5677_184V1V3_R2.fastq.gz


F5677.S094Visit 3 Subject 26103 Plaque 1 of 2zr5677_185V1V3_R1.fastq.gzzr5677_185V1V3_R2.fastq.gz


F5677.S095Visit 3 Subject 26104 Plaque 1 of 2zr5677_186V1V3_R1.fastq.gzzr5677_186V1V3_R2.fastq.gz


F5677.S096Visit 3 Subject 26105 Plaque 1 of 2zr5677_187V1V3_R1.fastq.gzzr5677_187V1V3_R2.fastq.gz


F5677.S097Visit 3 Subject 26106 Plaque 1 of 2zr5677_188V1V3_R1.fastq.gzzr5677_188V1V3_R2.fastq.gz


F5677.S098Visit 3 Subject 26108 Plaque 1 of 2zr5677_189V1V3_R1.fastq.gzzr5677_189V1V3_R2.fastq.gz


F5677.S099Visit 3 Subject 26109 Plaque 1 of 2zr5677_18V1V3_R1.fastq.gzzr5677_18V1V3_R2.fastq.gz


F5677.S100Visit 3 Subject 26110 Plaque 1 of 2zr5677_190V1V3_R1.fastq.gzzr5677_190V1V3_R2.fastq.gz


F5677.S101Visit 3 Subject 26111 Plaque 1 of 2zr5677_191V1V3_R1.fastq.gzzr5677_191V1V3_R2.fastq.gz


F5677.S102Visit 3 Subject 26113 Plaque 1 of 2zr5677_192V1V3_R1.fastq.gzzr5677_192V1V3_R2.fastq.gz


F5677.S103Visit 3 Subject 26114 Plaque 1 of 2zr5677_193V1V3_R1.fastq.gzzr5677_193V1V3_R2.fastq.gz


F5677.S104Visit 3 Subject 26115 Plaque 1 of 2zr5677_194V1V3_R1.fastq.gzzr5677_194V1V3_R2.fastq.gz


F5677.S105Visit 3 Subject 26116 Plaque 1 of 2zr5677_195V1V3_R1.fastq.gzzr5677_195V1V3_R2.fastq.gz


F5677.S106Visit 3 Subject 26118 Plaque 1 of 2zr5677_196V1V3_R1.fastq.gzzr5677_196V1V3_R2.fastq.gz


F5677.S107Visit 3 Subject 26119 Plaque 1 of 2zr5677_197V1V3_R1.fastq.gzzr5677_197V1V3_R2.fastq.gz


F5677.S108Visit 3 Subject 26120 Plaque 1 of 2zr5677_198V1V3_R1.fastq.gzzr5677_198V1V3_R2.fastq.gz


F5677.S109Visit 3 Subject 26121 Plaque 1 of 2zr5677_199V1V3_R1.fastq.gzzr5677_199V1V3_R2.fastq.gz


F5677.S110Visit 3 Subject 26122 Plaque 1 of 2zr5677_19V1V3_R1.fastq.gzzr5677_19V1V3_R2.fastq.gz


F5677.S111Visit 3 Subject 26123 Plaque 1 of 2zr5677_1V1V3_R1.fastq.gzzr5677_1V1V3_R2.fastq.gz


F5677.S112Visit 3 Subject 26124 Plaque 1 of 2zr5677_200V1V3_R1.fastq.gzzr5677_200V1V3_R2.fastq.gz


F5677.S113Visit 3 Subject 26125 Plaque 1 of 2zr5677_201V1V3_R1.fastq.gzzr5677_201V1V3_R2.fastq.gz


F5677.S114Visit 3 Subject 26126 Plaque 1 of 2zr5677_202V1V3_R1.fastq.gzzr5677_202V1V3_R2.fastq.gz


F5677.S115Visit 3 Subject 26127 Plaque 1 of 2zr5677_203V1V3_R1.fastq.gzzr5677_203V1V3_R2.fastq.gz


F5677.S116Visit 3 Subject 26129 Plaque 1 of 2zr5677_204V1V3_R1.fastq.gzzr5677_204V1V3_R2.fastq.gz


F5677.S117Visit 3 Subject 26131 Plaque 1 of 2zr5677_205V1V3_R1.fastq.gzzr5677_205V1V3_R2.fastq.gz


F5677.S118Visit 3 Subject 26132 Plaque 1 of 2zr5677_206V1V3_R1.fastq.gzzr5677_206V1V3_R2.fastq.gz


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F5677.S120Visit 3 Subject 26135 Plaque 1 of 2zr5677_208V1V3_R1.fastq.gzzr5677_208V1V3_R2.fastq.gz


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F5677.S271Visit 3 Subject 26015 Plaque 2 of 2zr5677_344V1V3_R1.fastq.gzzr5677_344V1V3_R2.fastq.gz


F5677.S272Visit 3 Subject 26016 Plaque 2 of 2zr5677_345V1V3_R1.fastq.gzzr5677_345V1V3_R2.fastq.gz


F5677.S273Visit 3 Subject 26017 Plaque 2 of 2zr5677_346V1V3_R1.fastq.gzzr5677_346V1V3_R2.fastq.gz


F5677.S274Visit 3 Subject 26018 Plaque 2 of 2zr5677_347V1V3_R1.fastq.gzzr5677_347V1V3_R2.fastq.gz


F5677.S275Visit 3 Subject 26019 Plaque 2 of 2zr5677_348V1V3_R1.fastq.gzzr5677_348V1V3_R2.fastq.gz


F5677.S276Visit 3 Subject 26020 Plaque 2 of 2zr5677_349V1V3_R1.fastq.gzzr5677_349V1V3_R2.fastq.gz


F5677.S277Visit 3 Subject 26021 Plaque 2 of 2zr5677_34V1V3_R1.fastq.gzzr5677_34V1V3_R2.fastq.gz


F5677.S278Visit 3 Subject 26022 Plaque 2 of 2zr5677_350V1V3_R1.fastq.gzzr5677_350V1V3_R2.fastq.gz


F5677.S279Visit 3 Subject 26023 Plaque 2 of 2zr5677_351V1V3_R1.fastq.gzzr5677_351V1V3_R2.fastq.gz


F5677.S280Visit 3 Subject 26024 Plaque 2 of 2zr5677_352V1V3_R1.fastq.gzzr5677_352V1V3_R2.fastq.gz


F5677.S281Visit 3 Subject 26027 Plaque 2 of 2zr5677_353V1V3_R1.fastq.gzzr5677_353V1V3_R2.fastq.gz


F5677.S282Visit 3 Subject 26028 Plaque 2 of 2zr5677_354V1V3_R1.fastq.gzzr5677_354V1V3_R2.fastq.gz


F5677.S283Visit 3 Subject 26029 Plaque 2 of 2zr5677_355V1V3_R1.fastq.gzzr5677_355V1V3_R2.fastq.gz


F5677.S284Visit 3 Subject 26030 Plaque 2 of 2zr5677_356V1V3_R1.fastq.gzzr5677_356V1V3_R2.fastq.gz


F5677.S285Visit 3 Subject 26031 Plaque 2 of 2zr5677_357V1V3_R1.fastq.gzzr5677_357V1V3_R2.fastq.gz


F5677.S286Visit 3 Subject 26032 Plaque 2 of 2zr5677_358V1V3_R1.fastq.gzzr5677_358V1V3_R2.fastq.gz


F5677.S287Visit 3 Subject 26033 Plaque 2 of 2zr5677_359V1V3_R1.fastq.gzzr5677_359V1V3_R2.fastq.gz


F5677.S288Visit 3 Subject 26034 Plaque 2 of 2zr5677_35V1V3_R1.fastq.gzzr5677_35V1V3_R2.fastq.gz


F5677.S289Visit 3 Subject 26035 Plaque 2 of 2zr5677_360V1V3_R1.fastq.gzzr5677_360V1V3_R2.fastq.gz


F5677.S290Visit 3 Subject 26036 Plaque 2 of 2zr5677_361V1V3_R1.fastq.gzzr5677_361V1V3_R2.fastq.gz


F5677.S291Visit 3 Subject 26037 Plaque 2 of 2zr5677_362V1V3_R1.fastq.gzzr5677_362V1V3_R2.fastq.gz


F5677.S292Visit 3 Subject 26038 Plaque 2 of 2zr5677_363V1V3_R1.fastq.gzzr5677_363V1V3_R2.fastq.gz


F5677.S293Visit 3 Subject 26039 Plaque 2 of 2zr5677_364V1V3_R1.fastq.gzzr5677_364V1V3_R2.fastq.gz


F5677.S294Visit 3 Subject 26040 Plaque 2 of 2zr5677_365V1V3_R1.fastq.gzzr5677_365V1V3_R2.fastq.gz


F5677.S295Visit 3 Subject 26042 Plaque 2 of 2zr5677_366V1V3_R1.fastq.gzzr5677_366V1V3_R2.fastq.gz


F5677.S296Visit 3 Subject 26043 Plaque 2 of 2zr5677_367V1V3_R1.fastq.gzzr5677_367V1V3_R2.fastq.gz


F5677.S297Visit 3 Subject 26044 Plaque 2 of 2zr5677_368V1V3_R1.fastq.gzzr5677_368V1V3_R2.fastq.gz


F5677.S298Visit 3 Subject 26045 Plaque 2 of 2zr5677_369V1V3_R1.fastq.gzzr5677_369V1V3_R2.fastq.gz


F5677.S299Visit 3 Subject 26046 Plaque 2 of 2zr5677_36V1V3_R1.fastq.gzzr5677_36V1V3_R2.fastq.gz


F5677.S300Visit 3 Subject 26047 Plaque 2 of 2zr5677_370V1V3_R1.fastq.gzzr5677_370V1V3_R2.fastq.gz


F5677.S301Visit 3 Subject 26048 Plaque 2 of 2zr5677_371V1V3_R1.fastq.gzzr5677_371V1V3_R2.fastq.gz


F5677.S302Visit 3 Subject 26050 Plaque 2 of 2zr5677_372V1V3_R1.fastq.gzzr5677_372V1V3_R2.fastq.gz


F5677.S303Visit 3 Subject 26052 Plaque 2 of 2zr5677_373V1V3_R1.fastq.gzzr5677_373V1V3_R2.fastq.gz


F5677.S304Visit 3 Subject 26054 Plaque 2 of 2zr5677_374V1V3_R1.fastq.gzzr5677_374V1V3_R2.fastq.gz


F5677.S305Visit 3 Subject 26055 Plaque 2 of 2zr5677_375V1V3_R1.fastq.gzzr5677_375V1V3_R2.fastq.gz


F5677.S306Visit 3 Subject 26056 Plaque 2 of 2zr5677_376V1V3_R1.fastq.gzzr5677_376V1V3_R2.fastq.gz


F5677.S307Visit 3 Subject 26057 Plaque 2 of 2zr5677_377V1V3_R1.fastq.gzzr5677_377V1V3_R2.fastq.gz


F5677.S308Visit 3 Subject 26058 Plaque 2 of 2zr5677_378V1V3_R1.fastq.gzzr5677_378V1V3_R2.fastq.gz


F5677.S309Visit 3 Subject 26059 Plaque 2 of 2zr5677_379V1V3_R1.fastq.gzzr5677_379V1V3_R2.fastq.gz


F5677.S310Visit 3 Subject 26061 Plaque 2 of 2zr5677_37V1V3_R1.fastq.gzzr5677_37V1V3_R2.fastq.gz


F5677.S311Visit 3 Subject 26062 Plaque 2 of 2zr5677_380V1V3_R1.fastq.gzzr5677_380V1V3_R2.fastq.gz


F5677.S312Visit 3 Subject 26063 Plaque 2 of 2zr5677_381V1V3_R1.fastq.gzzr5677_381V1V3_R2.fastq.gz


F5677.S313Visit 3 Subject 26064 Plaque 2 of 2zr5677_382V1V3_R1.fastq.gzzr5677_382V1V3_R2.fastq.gz


F5677.S314Visit 3 Subject 26065 Plaque 2 of 2zr5677_383V1V3_R1.fastq.gzzr5677_383V1V3_R2.fastq.gz


F5677.S315Visit 3 Subject 26066 Plaque 2 of 2zr5677_384V1V3_R1.fastq.gzzr5677_384V1V3_R2.fastq.gz


F5677.S316Visit 3 Subject 26067 Plaque 2 of 2zr5677_385V1V3_R1.fastq.gzzr5677_385V1V3_R2.fastq.gz


F5677.S317Visit 3 Subject 26068 Plaque 2 of 2zr5677_386V1V3_R1.fastq.gzzr5677_386V1V3_R2.fastq.gz


F5677.S318Visit 3 Subject 26070 Plaque 2 of 2zr5677_387V1V3_R1.fastq.gzzr5677_387V1V3_R2.fastq.gz


F5677.S319Visit 3 Subject 26071 Plaque 2 of 2zr5677_388V1V3_R1.fastq.gzzr5677_388V1V3_R2.fastq.gz


F5677.S320Visit 3 Subject 26072 Plaque 2 of 2zr5677_389V1V3_R1.fastq.gzzr5677_389V1V3_R2.fastq.gz


F5677.S321Visit 3 Subject 26073 Plaque 2 of 2zr5677_38V1V3_R1.fastq.gzzr5677_38V1V3_R2.fastq.gz


F5677.S322Visit 3 Subject 26075 Plaque 2 of 2zr5677_390V1V3_R1.fastq.gzzr5677_390V1V3_R2.fastq.gz


F5677.S323Visit 3 Subject 26076 Plaque 2 of 2zr5677_391V1V3_R1.fastq.gzzr5677_391V1V3_R2.fastq.gz


F5677.S324Visit 3 Subject 26077 Plaque 2 of 2zr5677_392V1V3_R1.fastq.gzzr5677_392V1V3_R2.fastq.gz


F5677.S325Visit 3 Subject 26078 Plaque 2 of 2zr5677_393V1V3_R1.fastq.gzzr5677_393V1V3_R2.fastq.gz


F5677.S326Visit 3 Subject 26079 Plaque 2 of 2zr5677_394V1V3_R1.fastq.gzzr5677_394V1V3_R2.fastq.gz


F5677.S327Visit 3 Subject 26080 Plaque 2 of 2zr5677_395V1V3_R1.fastq.gzzr5677_395V1V3_R2.fastq.gz


F5677.S328Visit 3 Subject 26081 Plaque 2 of 2zr5677_396V1V3_R1.fastq.gzzr5677_396V1V3_R2.fastq.gz


F5677.S329Visit 3 Subject 26082 Plaque 2 of 2zr5677_397V1V3_R1.fastq.gzzr5677_397V1V3_R2.fastq.gz


F5677.S330Visit 3 Subject 26083 Plaque 2 of 2zr5677_398V1V3_R1.fastq.gzzr5677_398V1V3_R2.fastq.gz


F5677.S331Visit 3 Subject 26084 Plaque 2 of 2zr5677_399V1V3_R1.fastq.gzzr5677_399V1V3_R2.fastq.gz


F5677.S332Visit 3 Subject 26085 Plaque 2 of 2zr5677_39V1V3_R1.fastq.gzzr5677_39V1V3_R2.fastq.gz


F5677.S333Visit 3 Subject 26086 Plaque 2 of 2zr5677_3V1V3_R1.fastq.gzzr5677_3V1V3_R2.fastq.gz


F5677.S334Visit 3 Subject 26087 Plaque 2 of 2zr5677_400V1V3_R1.fastq.gzzr5677_400V1V3_R2.fastq.gz


F5677.S335Visit 3 Subject 26088 Plaque 2 of 2zr5677_401V1V3_R1.fastq.gzzr5677_401V1V3_R2.fastq.gz


F5677.S336Visit 3 Subject 26089 Plaque 2 of 2zr5677_402V1V3_R1.fastq.gzzr5677_402V1V3_R2.fastq.gz


F5677.S337Visit 3 Subject 26090 Plaque 2 of 2zr5677_403V1V3_R1.fastq.gzzr5677_403V1V3_R2.fastq.gz


F5677.S338Visit 3 Subject 26091 Plaque 2 of 2zr5677_404V1V3_R1.fastq.gzzr5677_404V1V3_R2.fastq.gz


F5677.S339Visit 3 Subject 26092 Plaque 2 of 2zr5677_405V1V3_R1.fastq.gzzr5677_405V1V3_R2.fastq.gz


F5677.S340Visit 3 Subject 26093 Plaque 2 of 2zr5677_406V1V3_R1.fastq.gzzr5677_406V1V3_R2.fastq.gz


F5677.S341Visit 3 Subject 26094 Plaque 2 of 2zr5677_407V1V3_R1.fastq.gzzr5677_407V1V3_R2.fastq.gz


F5677.S342Visit 3 Subject 26095 Plaque 2 of 2zr5677_408V1V3_R1.fastq.gzzr5677_408V1V3_R2.fastq.gz


F5677.S343Visit 3 Subject 26096 Plaque 2 of 2zr5677_409V1V3_R1.fastq.gzzr5677_409V1V3_R2.fastq.gz


F5677.S344Visit 3 Subject 26097 Plaque 2 of 2zr5677_40V1V3_R1.fastq.gzzr5677_40V1V3_R2.fastq.gz


F5677.S345Visit 3 Subject 26098 Plaque 2 of 2zr5677_410V1V3_R1.fastq.gzzr5677_410V1V3_R2.fastq.gz


F5677.S346Visit 3 Subject 26099 Plaque 2 of 2zr5677_411V1V3_R1.fastq.gzzr5677_411V1V3_R2.fastq.gz


F5677.S347Visit 3 Subject 26100 Plaque 2 of 2zr5677_412V1V3_R1.fastq.gzzr5677_412V1V3_R2.fastq.gz


F5677.S348Visit 3 Subject 26101 Plaque 2 of 2zr5677_413V1V3_R1.fastq.gzzr5677_413V1V3_R2.fastq.gz


F5677.S349Visit 3 Subject 26102 Plaque 2 of 2zr5677_414V1V3_R1.fastq.gzzr5677_414V1V3_R2.fastq.gz


F5677.S350Visit 3 Subject 26103 Plaque 2 of 2zr5677_415V1V3_R1.fastq.gzzr5677_415V1V3_R2.fastq.gz


F5677.S351Visit 3 Subject 26104 Plaque 2 of 2zr5677_416V1V3_R1.fastq.gzzr5677_416V1V3_R2.fastq.gz


F5677.S352Visit 3 Subject 26105 Plaque 2 of 2zr5677_417V1V3_R1.fastq.gzzr5677_417V1V3_R2.fastq.gz


F5677.S353Visit 3 Subject 26106 Plaque 2 of 2zr5677_418V1V3_R1.fastq.gzzr5677_418V1V3_R2.fastq.gz


F5677.S354Visit 3 Subject 26108 Plaque 2 of 2zr5677_419V1V3_R1.fastq.gzzr5677_419V1V3_R2.fastq.gz


F5677.S355Visit 3 Subject 26109 Plaque 2 of 2zr5677_41V1V3_R1.fastq.gzzr5677_41V1V3_R2.fastq.gz


F5677.S356Visit 3 Subject 26110 Plaque 2 of 2zr5677_420V1V3_R1.fastq.gzzr5677_420V1V3_R2.fastq.gz


F5677.S357Visit 3 Subject 26111 Plaque 2 of 2zr5677_421V1V3_R1.fastq.gzzr5677_421V1V3_R2.fastq.gz


F5677.S358Visit 3 Subject 26113 Plaque 2 of 2zr5677_422V1V3_R1.fastq.gzzr5677_422V1V3_R2.fastq.gz


F5677.S359Visit 3 Subject 26114 Plaque 2 of 2zr5677_423V1V3_R1.fastq.gzzr5677_423V1V3_R2.fastq.gz


F5677.S360Visit 3 Subject 26115 Plaque 2 of 2zr5677_424V1V3_R1.fastq.gzzr5677_424V1V3_R2.fastq.gz


F5677.S361Visit 3 Subject 26116 Plaque 2 of 2zr5677_425V1V3_R1.fastq.gzzr5677_425V1V3_R2.fastq.gz


F5677.S362Visit 3 Subject 26118 Plaque 2 of 2zr5677_426V1V3_R1.fastq.gzzr5677_426V1V3_R2.fastq.gz


F5677.S363Visit 3 Subject 26119 Plaque 2 of 2zr5677_427V1V3_R1.fastq.gzzr5677_427V1V3_R2.fastq.gz


F5677.S364Visit 3 Subject 26120 Plaque 2 of 2zr5677_428V1V3_R1.fastq.gzzr5677_428V1V3_R2.fastq.gz


F5677.S365Visit 3 Subject 26121 Plaque 2 of 2zr5677_429V1V3_R1.fastq.gzzr5677_429V1V3_R2.fastq.gz


F5677.S366Visit 3 Subject 26122 Plaque 2 of 2zr5677_42V1V3_R1.fastq.gzzr5677_42V1V3_R2.fastq.gz


F5677.S367Visit 3 Subject 26123 Plaque 2 of 2zr5677_430V1V3_R1.fastq.gzzr5677_430V1V3_R2.fastq.gz


F5677.S368Visit 3 Subject 26124 Plaque 2 of 2zr5677_431V1V3_R1.fastq.gzzr5677_431V1V3_R2.fastq.gz


F5677.S369Visit 3 Subject 26125 Plaque 2 of 2zr5677_432V1V3_R1.fastq.gzzr5677_432V1V3_R2.fastq.gz


F5677.S370Visit 3 Subject 26126 Plaque 2 of 2zr5677_433V1V3_R1.fastq.gzzr5677_433V1V3_R2.fastq.gz


F5677.S371Visit 3 Subject 26127 Plaque 2 of 2zr5677_434V1V3_R1.fastq.gzzr5677_434V1V3_R2.fastq.gz


F5677.S372Visit 3 Subject 26129 Plaque 2 of 2zr5677_435V1V3_R1.fastq.gzzr5677_435V1V3_R2.fastq.gz


F5677.S373Visit 3 Subject 26131 Plaque 2 of 2zr5677_436V1V3_R1.fastq.gzzr5677_436V1V3_R2.fastq.gz


F5677.S374Visit 3 Subject 26132 Plaque 2 of 2zr5677_437V1V3_R1.fastq.gzzr5677_437V1V3_R2.fastq.gz


F5677.S375Visit 3 Subject 26134 Plaque 2 of 2zr5677_438V1V3_R1.fastq.gzzr5677_438V1V3_R2.fastq.gz


F5677.S376Visit 3 Subject 26135 Plaque 2 of 2zr5677_439V1V3_R1.fastq.gzzr5677_439V1V3_R2.fastq.gz


F5677.S377Visit 3 Subject 26136 Plaque 2 of 2zr5677_43V1V3_R1.fastq.gzzr5677_43V1V3_R2.fastq.gz


F5677.S378Visit 3 Subject 26140 Plaque 2 of 2zr5677_440V1V3_R1.fastq.gzzr5677_440V1V3_R2.fastq.gz


F5677.S379Visit 3 Subject 26141 Plaque 2 of 2zr5677_441V1V3_R1.fastq.gzzr5677_441V1V3_R2.fastq.gz


F5677.S380Visit 3 Subject 26142 Plaque 2 of 2zr5677_442V1V3_R1.fastq.gzzr5677_442V1V3_R2.fastq.gz


F5677.S381Visit 3 Subject 26143 Plaque 2 of 2zr5677_443V1V3_R1.fastq.gzzr5677_443V1V3_R2.fastq.gz


F5677.S382Visit 3 Subject 26144 Plaque 2 of 2zr5677_444V1V3_R1.fastq.gzzr5677_444V1V3_R2.fastq.gz


F5677.S383Visit 3 Subject 26145 Plaque 2 of 2zr5677_445V1V3_R1.fastq.gzzr5677_445V1V3_R2.fastq.gz


F5677.S384Visit 3 Subject 26146 Plaque 2 of 2zr5677_446V1V3_R1.fastq.gzzr5677_446V1V3_R2.fastq.gz


F5677.S385Visit 3 Subject 26147 Plaque 2 of 2zr5677_447V1V3_R1.fastq.gzzr5677_447V1V3_R2.fastq.gz


F5677.S386Visit 3 Subject 26148 Plaque 2 of 2zr5677_448V1V3_R1.fastq.gzzr5677_448V1V3_R2.fastq.gz


F5677.S387Visit 3 Subject 26149 Plaque 2 of 2zr5677_449V1V3_R1.fastq.gzzr5677_449V1V3_R2.fastq.gz


F5677.S388Visit 3 Subject 26151 Plaque 2 of 2zr5677_44V1V3_R1.fastq.gzzr5677_44V1V3_R2.fastq.gz


F5677.S389Visit 3 Subject 26152 Plaque 2 of 2zr5677_450V1V3_R1.fastq.gzzr5677_450V1V3_R2.fastq.gz


F5677.S390Visit 3 Subject 26154 Plaque 2 of 2zr5677_451V1V3_R1.fastq.gzzr5677_451V1V3_R2.fastq.gz


F5677.S391Visit 3 Subject 26155 Plaque 2 of 2zr5677_452V1V3_R1.fastq.gzzr5677_452V1V3_R2.fastq.gz


F5677.S392Visit 3 Subject 26156 Plaque 2 of 2zr5677_453V1V3_R1.fastq.gzzr5677_453V1V3_R2.fastq.gz


F5677.S393Visit 3 Subject 26157 Plaque 2 of 2zr5677_454V1V3_R1.fastq.gzzr5677_454V1V3_R2.fastq.gz


F5677.S394Visit 3 Subject 26158 Plaque 2 of 2zr5677_455V1V3_R1.fastq.gzzr5677_455V1V3_R2.fastq.gz


F5677.S395Visit 3 Subject 26159 Plaque 2 of 2zr5677_456V1V3_R1.fastq.gzzr5677_456V1V3_R2.fastq.gz


F5677.S396Visit 3 Subject 26160 Plaque 2 of 2zr5677_457V1V3_R1.fastq.gzzr5677_457V1V3_R2.fastq.gz


F5677.S397Visit 3 Subject 26161 Plaque 2 of 2zr5677_458V1V3_R1.fastq.gzzr5677_458V1V3_R2.fastq.gz


F5677.S398Visit 3 Subject 26162 Plaque 2 of 2zr5677_459V1V3_R1.fastq.gzzr5677_459V1V3_R2.fastq.gz


F5677.S399Visit 3 Subject 26163 Plaque 2 of 2zr5677_45V1V3_R1.fastq.gzzr5677_45V1V3_R2.fastq.gz


F5677.S400Visit 3 Subject 26164 Plaque 2 of 2zr5677_460V1V3_R1.fastq.gzzr5677_460V1V3_R2.fastq.gz


F5677.S401Visit 3 Subject 26165 Plaque 2 of 2zr5677_461V1V3_R1.fastq.gzzr5677_461V1V3_R2.fastq.gz


F5677.S402Visit 3 Subject 26166 Plaque 2 of 2zr5677_462V1V3_R1.fastq.gzzr5677_462V1V3_R2.fastq.gz


F5677.S403Visit 3 Subject 26167 Plaque 2 of 2zr5677_463V1V3_R1.fastq.gzzr5677_463V1V3_R2.fastq.gz


F5677.S404Visit 3 Subject 26168 Plaque 2 of 2zr5677_464V1V3_R1.fastq.gzzr5677_464V1V3_R2.fastq.gz


F5677.S405Visit 3 Subject 26170 Plaque 2 of 2zr5677_465V1V3_R1.fastq.gzzr5677_465V1V3_R2.fastq.gz


F5677.S406Visit 3 Subject 26171 Plaque 2 of 2zr5677_466V1V3_R1.fastq.gzzr5677_466V1V3_R2.fastq.gz


F5677.S407Visit 3 Subject 26173 Plaque 2 of 2zr5677_467V1V3_R1.fastq.gzzr5677_467V1V3_R2.fastq.gz


F5677.S408Visit 3 Subject 26174 Plaque 2 of 2zr5677_468V1V3_R1.fastq.gzzr5677_468V1V3_R2.fastq.gz


F5677.S409Visit 3 Subject 26175 Plaque 2 of 2zr5677_469V1V3_R1.fastq.gzzr5677_469V1V3_R2.fastq.gz


F5677.S410Visit 3 Subject 26176 Plaque 2 of 2zr5677_46V1V3_R1.fastq.gzzr5677_46V1V3_R2.fastq.gz


F5677.S411Visit 3 Subject 26177 Plaque 2 of 2zr5677_470V1V3_R1.fastq.gzzr5677_470V1V3_R2.fastq.gz


F5677.S412Visit 3 Subject 26178 Plaque 2 of 2zr5677_471V1V3_R1.fastq.gzzr5677_471V1V3_R2.fastq.gz


F5677.S413Visit 9 Subject 26001 Plaque 2 of 2zr5677_472V1V3_R1.fastq.gzzr5677_472V1V3_R2.fastq.gz


F5677.S414Visit 9 Subject 26003 Plaque 2of 2zr5677_473V1V3_R1.fastq.gzzr5677_473V1V3_R2.fastq.gz


F5677.S415Visit 9 Subject 26005 Plaque 2 of 2zr5677_474V1V3_R1.fastq.gzzr5677_474V1V3_R2.fastq.gz


F5677.S416Visit 9 Subject 26006 Plaque 2 of 2zr5677_475V1V3_R1.fastq.gzzr5677_475V1V3_R2.fastq.gz


F5677.S417Visit 9 Subject 26008 Plaque 2 of 2zr5677_476V1V3_R1.fastq.gzzr5677_476V1V3_R2.fastq.gz


F5677.S418Visit 9 Subject 26009 Plaque 2 of 2zr5677_477V1V3_R1.fastq.gzzr5677_477V1V3_R2.fastq.gz


F5677.S419Visit 9 Subject 26012 Plaque 2 of 2zr5677_478V1V3_R1.fastq.gzzr5677_478V1V3_R2.fastq.gz


F5677.S420Visit 9 Subject 26013 Plaque 2 of 2zr5677_479V1V3_R1.fastq.gzzr5677_479V1V3_R2.fastq.gz


F5677.S421Visit 9 Subject 26014 Plaque 2 of 2zr5677_47V1V3_R1.fastq.gzzr5677_47V1V3_R2.fastq.gz


F5677.S422Visit 9 Subject 26015 Plaque 2 of 2zr5677_480V1V3_R1.fastq.gzzr5677_480V1V3_R2.fastq.gz


F5677.S423Visit 9 Subject 26016 Plaque 2 of 2zr5677_481V1V3_R1.fastq.gzzr5677_481V1V3_R2.fastq.gz


F5677.S424Visit 9 Subject 26018 Plaque 2 of 2zr5677_482V1V3_R1.fastq.gzzr5677_482V1V3_R2.fastq.gz


F5677.S425Visit 9 Subject 26019 Plaque 2 of 2zr5677_483V1V3_R1.fastq.gzzr5677_483V1V3_R2.fastq.gz


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F5677.S428Visit 9 Subject 26027 Plaque 2 of 2zr5677_486V1V3_R1.fastq.gzzr5677_486V1V3_R2.fastq.gz


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F5677.S434Visit 9 Subject 26037 Plaque 2 of 2zr5677_491V1V3_R1.fastq.gzzr5677_491V1V3_R2.fastq.gz


F5677.S435Visit 9 Subject 26040 Plaque 2 of 2zr5677_492V1V3_R1.fastq.gzzr5677_492V1V3_R2.fastq.gz


F5677.S436Visit 9 Subject 26042 Plaque 2 of 2zr5677_493V1V3_R1.fastq.gzzr5677_493V1V3_R2.fastq.gz


F5677.S437Visit 9 Subject 26044 Plaque 2 of 2zr5677_494V1V3_R1.fastq.gzzr5677_494V1V3_R2.fastq.gz


F5677.S438Visit 9 Subject 26046 Plaque 2 of 2zr5677_495V1V3_R1.fastq.gzzr5677_495V1V3_R2.fastq.gz


F5677.S439Visit 9 Subject 26048 Plaque 2 of 2zr5677_496V1V3_R1.fastq.gzzr5677_496V1V3_R2.fastq.gz


F5677.S440Visit 9 Subject 26050 Plaque 2 of 2zr5677_497V1V3_R1.fastq.gzzr5677_497V1V3_R2.fastq.gz


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F5677.S442Visit 9 Subject 26054 Plaque 2 of 2zr5677_499V1V3_R1.fastq.gzzr5677_499V1V3_R2.fastq.gz


F5677.S443Visit 9 Subject 26055 Plaque 2 of 2zr5677_49V1V3_R1.fastq.gzzr5677_49V1V3_R2.fastq.gz


F5677.S444Visit 9 Subject 26059 Plaque 2 of 2zr5677_4V1V3_R1.fastq.gzzr5677_4V1V3_R2.fastq.gz


F5677.S445Visit 9 Subject 26061 Plaque 2 of 2zr5677_500V1V3_R1.fastq.gzzr5677_500V1V3_R2.fastq.gz


F5677.S446Visit 9 Subject 26062 Plaque 2of 2zr5677_501V1V3_R1.fastq.gzzr5677_501V1V3_R2.fastq.gz


F5677.S447Visit 9 Subject 26065 Plaque 2 of 2zr5677_502V1V3_R1.fastq.gzzr5677_502V1V3_R2.fastq.gz


F5677.S448Visit 9 Subject 26066 Plaque 2 of 2zr5677_503V1V3_R1.fastq.gzzr5677_503V1V3_R2.fastq.gz


F5677.S449Visit 9 Subject 26067 Plaque 2 of 2zr5677_504V1V3_R1.fastq.gzzr5677_504V1V3_R2.fastq.gz


F5677.S450Visit 9 Subject 26072 Plaque 2 of 2zr5677_505V1V3_R1.fastq.gzzr5677_505V1V3_R2.fastq.gz


F5677.S451Visit 9 Subject 26073 Plaque 2 of 2zr5677_506V1V3_R1.fastq.gzzr5677_506V1V3_R2.fastq.gz


F5677.S452Visit 9 Subject 26079 Plaque 2 of 2zr5677_507V1V3_R1.fastq.gzzr5677_507V1V3_R2.fastq.gz


F5677.S453Visit 9 Subject 26080 Plaque 2 of 2zr5677_508V1V3_R1.fastq.gzzr5677_508V1V3_R2.fastq.gz


F5677.S454Visit 9 Subject 26081 Plaque 2 of 2zr5677_509V1V3_R1.fastq.gzzr5677_509V1V3_R2.fastq.gz


F5677.S455Visit 9 Subject 26083 Plaque 2 of 2zr5677_50V1V3_R1.fastq.gzzr5677_50V1V3_R2.fastq.gz


F5677.S456Visit 9 Subject 26084 Plaque 2 of 2zr5677_510V1V3_R1.fastq.gzzr5677_510V1V3_R2.fastq.gz


F5677.S457Visit 9 Subject 26085 Plaque 2 of 2zr5677_511V1V3_R1.fastq.gzzr5677_511V1V3_R2.fastq.gz


F5677.S458Visit 9 Subject 26086 Plaque 2 of 2zr5677_512V1V3_R1.fastq.gzzr5677_512V1V3_R2.fastq.gz


F5677.S459Visit 9 Subject 26087 Plaque 2 of 2zr5677_513V1V3_R1.fastq.gzzr5677_513V1V3_R2.fastq.gz


F5677.S460Visit 9 Subject 26089 Plaque 2 of 2zr5677_514V1V3_R1.fastq.gzzr5677_514V1V3_R2.fastq.gz


F5677.S461Visit 9 Subject 26090 Plaque 2 of 2zr5677_515V1V3_R1.fastq.gzzr5677_515V1V3_R2.fastq.gz


F5677.S462Visit 9 Subject 26091 Plaque 2 of 2zr5677_516V1V3_R1.fastq.gzzr5677_516V1V3_R2.fastq.gz


F5677.S463Visit 9 Subject 26093 Plaque 2 of 2zr5677_517V1V3_R1.fastq.gzzr5677_517V1V3_R2.fastq.gz


F5677.S464Visit 9 Subject 26094 Plaque 2 of 2zr5677_518V1V3_R1.fastq.gzzr5677_518V1V3_R2.fastq.gz


F5677.S465Visit 9 Subject 26095 Plaque 2 of 2zr5677_519V1V3_R1.fastq.gzzr5677_519V1V3_R2.fastq.gz


F5677.S466Visit 9 Subject 26097 Plaque 2 of 2zr5677_51V1V3_R1.fastq.gzzr5677_51V1V3_R2.fastq.gz


F5677.S467Visit 9 Subject 26099 Plaque 2 of 2zr5677_520V1V3_R1.fastq.gzzr5677_520V1V3_R2.fastq.gz


F5677.S468Visit 9 Subject 26100 Plaque 2 of 2zr5677_521V1V3_R1.fastq.gzzr5677_521V1V3_R2.fastq.gz


F5677.S469Visit 9 Subject 26102 Plaque 2 of 2zr5677_522V1V3_R1.fastq.gzzr5677_522V1V3_R2.fastq.gz


F5677.S470Visit 9 Subject 26103 Plaque 2 of 2zr5677_523V1V3_R1.fastq.gzzr5677_523V1V3_R2.fastq.gz


F5677.S471Visit 9 Subject 26105 Plaque 2 of 2zr5677_524V1V3_R1.fastq.gzzr5677_524V1V3_R2.fastq.gz


F5677.S472Visit 9 Subject 26106 Plaque 2 of 2zr5677_525V1V3_R1.fastq.gzzr5677_525V1V3_R2.fastq.gz


F5677.S473Visit 9 Subject 26109 Plaque 2 of 2zr5677_526V1V3_R1.fastq.gzzr5677_526V1V3_R2.fastq.gz


F5677.S474Visit 9 Subject 26111 Plaque 2 of 2zr5677_527V1V3_R1.fastq.gzzr5677_527V1V3_R2.fastq.gz


F5677.S475Visit 9 Subject 26114 Plaque 2 of 2zr5677_528V1V3_R1.fastq.gzzr5677_528V1V3_R2.fastq.gz


F5677.S476Visit 9 Subject 26115 Plaque 2 of 2zr5677_529V1V3_R1.fastq.gzzr5677_529V1V3_R2.fastq.gz


F5677.S477Visit 9 Subject 26116 Plaque 2 of 2zr5677_52V1V3_R1.fastq.gzzr5677_52V1V3_R2.fastq.gz


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F5677.S479Visit 9 Subject 26120 Plaque 2 of 2zr5677_531V1V3_R1.fastq.gzzr5677_531V1V3_R2.fastq.gz


F5677.S480Visit 9 Subject 26121 Plaque 2 of 2zr5677_532V1V3_R1.fastq.gzzr5677_532V1V3_R2.fastq.gz


F5677.S481Visit 9 Subject 26123 Plaque 2 of 2zr5677_533V1V3_R1.fastq.gzzr5677_533V1V3_R2.fastq.gz


F5677.S482Visit 9 Subject 26125 Plaque 2 of 2zr5677_534V1V3_R1.fastq.gzzr5677_534V1V3_R2.fastq.gz


F5677.S483Visit 9 Subject 26126 Plaque 2 of 2zr5677_535V1V3_R1.fastq.gzzr5677_535V1V3_R2.fastq.gz


F5677.S484Visit 9 Subject 26129 Plaque 2 of 2zr5677_536V1V3_R1.fastq.gzzr5677_536V1V3_R2.fastq.gz


F5677.S485Visit 9 Subject 26131 Plaque 2 of 2zr5677_537V1V3_R1.fastq.gzzr5677_537V1V3_R2.fastq.gz


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F5677.S487Visit 9 Subject 26140 Plaque 2 of 2zr5677_539V1V3_R1.fastq.gzzr5677_539V1V3_R2.fastq.gz


F5677.S488Visit 9 Subject 26142 Plaque 2 of 2zr5677_53V1V3_R1.fastq.gzzr5677_53V1V3_R2.fastq.gz


F5677.S489Visit 9 Subject 26143 Plaque 2 of 2zr5677_540V1V3_R1.fastq.gzzr5677_540V1V3_R2.fastq.gz


F5677.S490Visit 9 Subject 26144 Plaque 2 of 2zr5677_541V1V3_R1.fastq.gzzr5677_541V1V3_R2.fastq.gz


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F5677.S492Visit 9 Subject 26147 Plaque 2 of 2zr5677_543V1V3_R1.fastq.gzzr5677_543V1V3_R2.fastq.gz


F5677.S493Visit 9 Subject 26148 Plaque 2 of 2zr5677_544V1V3_R1.fastq.gzzr5677_544V1V3_R2.fastq.gz


F5677.S494Visit 9 Subject 26149 Plaque 2 of 2zr5677_545V1V3_R1.fastq.gzzr5677_545V1V3_R2.fastq.gz


F5677.S495Visit 9 Subject 26151 Plaque 2 of 2zr5677_546V1V3_R1.fastq.gzzr5677_546V1V3_R2.fastq.gz


F5677.S496Visit 9 Subject 26152 Plaque 2 of 2zr5677_547V1V3_R1.fastq.gzzr5677_547V1V3_R2.fastq.gz


F5677.S497Visit 9 Subject 26154 Plaque 2 of 2zr5677_548V1V3_R1.fastq.gzzr5677_548V1V3_R2.fastq.gz


F5677.S498Visit 9 Subject 26155 Plaque 2 of 2zr5677_549V1V3_R1.fastq.gzzr5677_549V1V3_R2.fastq.gz


F5677.S499Visit 9 Subject 26157 Plaque 2 of 2zr5677_54V1V3_R1.fastq.gzzr5677_54V1V3_R2.fastq.gz


F5677.S500Visit 9 Subject 26160 Plaque 2 of 2zr5677_550V1V3_R1.fastq.gzzr5677_550V1V3_R2.fastq.gz


F5677.S501Visit 9 Subject 26161 Plaque 2 of 2zr5677_551V1V3_R1.fastq.gzzr5677_551V1V3_R2.fastq.gz


F5677.S502Visit 9 Subject 26162 Plaque 2 of 2zr5677_552V1V3_R1.fastq.gzzr5677_552V1V3_R2.fastq.gz


F5677.S503Visit 9 Subject 26163 Plaque 2 of 2zr5677_553V1V3_R1.fastq.gzzr5677_553V1V3_R2.fastq.gz


F5677.S504Visit 9 Subject 26164 Plaque 2 of 2zr5677_554V1V3_R1.fastq.gzzr5677_554V1V3_R2.fastq.gz


F5677.S505Visit 9 Subject 26165 Plaque 2 of 2zr5677_555V1V3_R1.fastq.gzzr5677_555V1V3_R2.fastq.gz


F5677.S506Visit 9 Subject 26167 Plaque 2 of 2zr5677_556V1V3_R1.fastq.gzzr5677_556V1V3_R2.fastq.gz


F5677.S507Visit 9 Subject 26168 Plaque 2 of 2zr5677_557V1V3_R1.fastq.gzzr5677_557V1V3_R2.fastq.gz


F5677.S508Visit 9 Subject 26170 Plaque 2 of 2zr5677_558V1V3_R1.fastq.gzzr5677_558V1V3_R2.fastq.gz


F5677.S509Visit 9 Subject 26173 Plaque 2 of 2zr5677_559V1V3_R1.fastq.gzzr5677_559V1V3_R2.fastq.gz


F5677.S510Visit 9 Subject 26175 Plaque 2 of 2zr5677_55V1V3_R1.fastq.gzzr5677_55V1V3_R2.fastq.gz


F5677.S511Visit 9 Subject 26176 Plaque 2 of 2zr5677_560V1V3_R1.fastq.gzzr5677_560V1V3_R2.fastq.gz


F5677.S512Visit 9 Subject 26177 Plaque 2 of 2zr5677_561V1V3_R1.fastq.gzzr5677_561V1V3_R2.fastq.gz


F5677.S513Visit 15 Subject 26001 Plaque 1 of 2zr5677_562V1V3_R1.fastq.gzzr5677_562V1V3_R2.fastq.gz


F5677.S514Visit 15 Subject 26003 Plaque 1 of 2zr5677_563V1V3_R1.fastq.gzzr5677_563V1V3_R2.fastq.gz


F5677.S515Visit 15 Subject 26005 Plaque 1 of 2zr5677_564V1V3_R1.fastq.gzzr5677_564V1V3_R2.fastq.gz


F5677.S516Visit 15 Subject 26006 Plaque 1 of 2zr5677_565V1V3_R1.fastq.gzzr5677_565V1V3_R2.fastq.gz


F5677.S517Visit 15 Subject 26008 Plaque 1 of 2zr5677_566V1V3_R1.fastq.gzzr5677_566V1V3_R2.fastq.gz


F5677.S518Visit 15 Subject 26009 Plaque 1 of 2zr5677_567V1V3_R1.fastq.gzzr5677_567V1V3_R2.fastq.gz


F5677.S519Visit 15 Subject 26012 Plaque 1 of 2zr5677_568V1V3_R1.fastq.gzzr5677_568V1V3_R2.fastq.gz


F5677.S520Visit 15 Subject 26013 Plaque 1 of 2zr5677_569V1V3_R1.fastq.gzzr5677_569V1V3_R2.fastq.gz


F5677.S521Visit 15 Subject 26014 Plaque 1 of 2zr5677_56V1V3_R1.fastq.gzzr5677_56V1V3_R2.fastq.gz


F5677.S522Visit 15 Subject 26015 Plaque 1 of 2zr5677_570V1V3_R1.fastq.gzzr5677_570V1V3_R2.fastq.gz


F5677.S523Visit 15 Subject 26016 Plaque 1 of 2zr5677_571V1V3_R1.fastq.gzzr5677_571V1V3_R2.fastq.gz


F5677.S524Visit 15 Subject 26018 Plaque 1 of 2zr5677_572V1V3_R1.fastq.gzzr5677_572V1V3_R2.fastq.gz


F5677.S525Visit 15 Subject 26019 Plaque 1 of 2zr5677_573V1V3_R1.fastq.gzzr5677_573V1V3_R2.fastq.gz


F5677.S526Visit 15 Subject 26020 Plaque 1 of 2zr5677_574V1V3_R1.fastq.gzzr5677_574V1V3_R2.fastq.gz


F5677.S527Visit 15 Subject 26027 Plaque 1 of 2zr5677_575V1V3_R1.fastq.gzzr5677_575V1V3_R2.fastq.gz


F5677.S528Visit 15 Subject 26029 Plaque 1 of 2zr5677_576V1V3_R1.fastq.gzzr5677_576V1V3_R2.fastq.gz


F5677.S529Visit 15 Subject 26030 Plaque 1 of 2zr5677_577V1V3_R1.fastq.gzzr5677_577V1V3_R2.fastq.gz


F5677.S530Visit 15 Subject 26031 Plaque 1 of 2zr5677_578V1V3_R1.fastq.gzzr5677_578V1V3_R2.fastq.gz


F5677.S531Visit 15 Subject 26032 Plaque 1 of 2zr5677_579V1V3_R1.fastq.gzzr5677_579V1V3_R2.fastq.gz


F5677.S532Visit 15 Subject 26033 Plaque 1 of 2zr5677_57V1V3_R1.fastq.gzzr5677_57V1V3_R2.fastq.gz


F5677.S533Visit 15 Subject 26037 Plaque 1 of 2zr5677_580V1V3_R1.fastq.gzzr5677_580V1V3_R2.fastq.gz


F5677.S534Visit 15 Subject 26040 Plaque 1 of 2zr5677_581V1V3_R1.fastq.gzzr5677_581V1V3_R2.fastq.gz


F5677.S535Visit 15 Subject 26044 Plaque 1 of 2zr5677_582V1V3_R1.fastq.gzzr5677_582V1V3_R2.fastq.gz


F5677.S536Visit 15 Subject 26046 Plaque 1 of 2zr5677_583V1V3_R1.fastq.gzzr5677_583V1V3_R2.fastq.gz


F5677.S537Visit 15 Subject 26048 Plaque 1 of 2zr5677_584V1V3_R1.fastq.gzzr5677_584V1V3_R2.fastq.gz


F5677.S538Visit 15 Subject 26050 Plaque 1 of 2zr5677_585V1V3_R1.fastq.gzzr5677_585V1V3_R2.fastq.gz


F5677.S539Visit 15 Subject 26052 Plaque 1 of 2zr5677_586V1V3_R1.fastq.gzzr5677_586V1V3_R2.fastq.gz


F5677.S540Visit 15 Subject 26054 Plaque 1 of 2zr5677_587V1V3_R1.fastq.gzzr5677_587V1V3_R2.fastq.gz


F5677.S541Visit 15 Subject 26055 Plaque 1 of 2zr5677_588V1V3_R1.fastq.gzzr5677_588V1V3_R2.fastq.gz


F5677.S542Visit 15 Subject 26059 Plaque 1 of 2zr5677_589V1V3_R1.fastq.gzzr5677_589V1V3_R2.fastq.gz


F5677.S543Visit 15 Subject 26061 Plaque 1 of 2zr5677_58V1V3_R1.fastq.gzzr5677_58V1V3_R2.fastq.gz


F5677.S544Visit 15 Subject 26062 Plaque 1 of 2zr5677_590V1V3_R1.fastq.gzzr5677_590V1V3_R2.fastq.gz


F5677.S545Visit 15 Subject 26066 Plaque 1 of 2zr5677_591V1V3_R1.fastq.gzzr5677_591V1V3_R2.fastq.gz


F5677.S546Visit 15 Subject 26067 Plaque 1 of 2zr5677_592V1V3_R1.fastq.gzzr5677_592V1V3_R2.fastq.gz


F5677.S547Visit 15 Subject 26072 Plaque 1 of 2zr5677_593V1V3_R1.fastq.gzzr5677_593V1V3_R2.fastq.gz


F5677.S548Visit 15 Subject 26073 Plaque 1 of 2zr5677_594V1V3_R1.fastq.gzzr5677_594V1V3_R2.fastq.gz


F5677.S549Visit 15 Subject 26079 Plaque 1 of 2zr5677_595V1V3_R1.fastq.gzzr5677_595V1V3_R2.fastq.gz


F5677.S550Visit 15 Subject 26080 Plaque 1 of 2zr5677_596V1V3_R1.fastq.gzzr5677_596V1V3_R2.fastq.gz


F5677.S551Visit 15 Subject 26081 Plaque 1 of 2zr5677_597V1V3_R1.fastq.gzzr5677_597V1V3_R2.fastq.gz


F5677.S552Visit 15 Subject 26083 Plaque 1 of 2zr5677_598V1V3_R1.fastq.gzzr5677_598V1V3_R2.fastq.gz


F5677.S553Visit 15 Subject 26084 Plaque 1 of 2zr5677_599V1V3_R1.fastq.gzzr5677_599V1V3_R2.fastq.gz


F5677.S554Visit 15 Subject 26085 Plaque 1 of 2zr5677_59V1V3_R1.fastq.gzzr5677_59V1V3_R2.fastq.gz


F5677.S555Visit 15 Subject 26086 Plaque 1 of 2zr5677_5V1V3_R1.fastq.gzzr5677_5V1V3_R2.fastq.gz


F5677.S556Visit 15 Subject 26087 Plaque 1 of 2zr5677_600V1V3_R1.fastq.gzzr5677_600V1V3_R2.fastq.gz


F5677.S557Visit 15 Subject 26089 Plaque 1 of 2zr5677_601V1V3_R1.fastq.gzzr5677_601V1V3_R2.fastq.gz


F5677.S558Visit 15 Subject 26090 Plaque 1 of 2zr5677_602V1V3_R1.fastq.gzzr5677_602V1V3_R2.fastq.gz


F5677.S559Visit 15 Subject 26091 Plaque 1 of 2zr5677_603V1V3_R1.fastq.gzzr5677_603V1V3_R2.fastq.gz


F5677.S560Visit 15 Subject 26094 Plaque 1 of 2zr5677_604V1V3_R1.fastq.gzzr5677_604V1V3_R2.fastq.gz


F5677.S561Visit 15 Subject 26095 Plaque 1 of 2zr5677_605V1V3_R1.fastq.gzzr5677_605V1V3_R2.fastq.gz


F5677.S562Visit 15 Subject 26099 Plaque 1 of 2zr5677_606V1V3_R1.fastq.gzzr5677_606V1V3_R2.fastq.gz


F5677.S563Visit 15 Subject 26102 Plaque 1 of 2zr5677_607V1V3_R1.fastq.gzzr5677_607V1V3_R2.fastq.gz


F5677.S564Visit 15 Subject 26103 Plaque 1 of 2zr5677_608V1V3_R1.fastq.gzzr5677_608V1V3_R2.fastq.gz


F5677.S565Visit 15 Subject 26105 Plaque 1 of 2zr5677_609V1V3_R1.fastq.gzzr5677_609V1V3_R2.fastq.gz


F5677.S566Visit 15 Subject 26106 Plaque 1 of 2zr5677_60V1V3_R1.fastq.gzzr5677_60V1V3_R2.fastq.gz


F5677.S567Visit 15 Subject 26109 Plaque 1 of 2zr5677_610V1V3_R1.fastq.gzzr5677_610V1V3_R2.fastq.gz


F5677.S568Visit 15 Subject 26111 Plaque 1 of 2zr5677_611V1V3_R1.fastq.gzzr5677_611V1V3_R2.fastq.gz


F5677.S569Visit 15 Subject 26116 Plaque 1 of 2zr5677_612V1V3_R1.fastq.gzzr5677_612V1V3_R2.fastq.gz


F5677.S570Visit 15 Subject 26118 Plaque 1 of 2zr5677_613V1V3_R1.fastq.gzzr5677_613V1V3_R2.fastq.gz


F5677.S571Visit 15 Subject 26121 Plaque 1 of 2zr5677_614V1V3_R1.fastq.gzzr5677_614V1V3_R2.fastq.gz


F5677.S572Visit 15 Subject 26123 Plaque 1 of 2zr5677_615V1V3_R1.fastq.gzzr5677_615V1V3_R2.fastq.gz


F5677.S573Visit 15 Subject 26126 Plaque 1 of 2zr5677_616V1V3_R1.fastq.gzzr5677_616V1V3_R2.fastq.gz


F5677.S574Visit 15 Subject 26131 Plaque 1 of 2zr5677_617V1V3_R1.fastq.gzzr5677_617V1V3_R2.fastq.gz


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Please download and save the file to your computer storage device. The download link will expire after 60 days upon your receiving of this report.

Raw sequence data download link:

 

VI. Analysis - DADA2 Read Processing

What is DADA2?

DADA2 is a software package that models and corrects Illumina-sequenced amplicon errors. DADA2 infers sample sequences exactly, without coarse-graining into OTUs, and resolves differences of as little as one nucleotide. DADA2 identified more real variants and output fewer spurious sequences than other methods.

DADA2’s advantage is that it uses more of the data. The DADA2 error model incorporates quality information, which is ignored by all other methods after filtering. The DADA2 error model incorporates quantitative abundances, whereas most other methods use abundance ranks if they use abundance at all. The DADA2 error model identifies the differences between sequences, eg. A->C, whereas other methods merely count the mismatches. DADA2 can parameterize its error model from the data itself, rather than relying on previous datasets that may or may not reflect the PCR and sequencing protocols used in your study.

DADA2 Publication: Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP. DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods. 2016 Jul;13(7):581-3. doi: 10.1038/nmeth.3869. Epub 2016 May 23. PMID: 27214047; PMCID: PMC4927377.

DADA2 Software Package is available as an R package at : https://benjjneb.github.io/dada2/index.html

Analysis Procedures:

DADA2 pipeline includes several tools for read quality control, including quality filtering, trimming, denoising, pair merging and chimera filtering. Below are the major processing steps of DADA2:

Step 1. Read trimming based on sequence quality The quality of NGS Illumina sequences often decreases toward the end of the reads. DADA2 allows to trim off the poor quality read ends in order to improve the error model building and pair mergicing performance.

Step 2. Learn the Error Rates The DADA2 algorithm makes use of a parametric error model (err) and every amplicon dataset has a different set of error rates. The learnErrors method learns this error model from the data, by alternating estimation of the error rates and inference of sample composition until they converge on a jointly consistent solution. As in many machine-learning problems, the algorithm must begin with an initial guess, for which the maximum possible error rates in this data are used (the error rates if only the most abundant sequence is correct and all the rest are errors).

Step 3. Infer amplicon sequence variants (ASVs) based on the error model built in previous step. This step is also called sequence "denoising". The outcome of this step is a list of ASVs that are the equivalent of oligonucleotides.

Step 4. Merge paired reads. If the sequencing products are read pairs, DADA2 will merge the R1 and R2 ASVs into single sequences. Merging is performed by aligning the denoised forward reads with the reverse-complement of the corresponding denoised reverse reads, and then constructing the merged “contig” sequences. By default, merged sequences are only output if the forward and reverse reads overlap by at least 12 bases, and are identical to each other in the overlap region (but these conditions can be changed via function arguments).

Step 5. Remove chimera. The core dada method corrects substitution and indel errors, but chimeras remain. Fortunately, the accuracy of sequence variants after denoising makes identifying chimeric ASVs simpler than when dealing with fuzzy OTUs. Chimeric sequences are identified if they can be exactly reconstructed by combining a left-segment and a right-segment from two more abundant “parent” sequences. The frequency of chimeric sequences varies substantially from dataset to dataset, and depends on on factors including experimental procedures and sample complexity.

Results

1. Read Quality Plots NGS sequence analaysis starts with visualizing the quality of the sequencing. Below are the quality plots of the first sample for the R1 and R2 reads separately. In gray-scale is a heat map of the frequency of each quality score at each base position. The mean quality score at each position is shown by the green line, and the quartiles of the quality score distribution by the orange lines. The forward reads are usually of better quality. It is a common practice to trim the last few nucleotides to avoid less well-controlled errors that can arise there. The trimming affects the downstream steps including error model building, merging and chimera calling. FOMC uses an empirical approach to test many combinations of different trim length in order to achieve best final amplicon sequence variants (ASVs), see the next section “Optimal trim length for ASVs”.

Specific to this project only, since there are over 600 samples, they were sequenced in 3 batches - Part 1, Part 2, and Part 3. Hence the DADA2 read quality plotting were also done in 3 parts.

Below is only the quality plots of Read 1 and 2 of the first sample:

2. Optimal trim length for ASVs The final number of merged and chimera-filtered ASVs depends on the quality filtering (hence trimming) in the very beginning of the DADA2 pipeline. In order to achieve highest number of ASVs, an empirical approach was used -

  1. Create a random subset of each sample consisting of 5,000 R1 and 5,000 R2 (to reduce computation time)
  2. Trim 10 bases at a time from the ends of both R1 and R2 up to 50 bases
  3. For each combination of trimmed length (e.g., 300x300, 300x290, 290x290 etc), the trimmed reads are subject to the entire DADA2 pipeline for chimera-filtered merged ASVs
  4. The combination with highest percentage of the input reads becoming final ASVs is selected for the complete set of data

Specific to this project only, since there are 3 sequencing batches - Part 1, Part 2, and Part 3, this step was done seperately for individual parts. Hence each batch (part) has a different trim length combination.

 

3. Error plots from learning the error rates After DADA2 building the error model for the set of data, it is always worthwhile, as a sanity check if nothing else, to visualize the estimated error rates. The error rates for each possible transition (A→C, A→G, …) are shown below. Points are the observed error rates for each consensus quality score. The black line shows the estimated error rates after convergence of the machine-learning algorithm. The red line shows the error rates expected under the nominal definition of the Q-score. The ideal result would be the estimated error rates (black line) are a good fit to the observed rates (points), and the error rates drop with increased quality as expected.

Specific to this project only, since there are over 600 samples, they were sequenced in 3 batches - Part 1, Part 2, and Part 3. Hence the DADA2 error models were also built in 3 parts. Following error modeling, ASVs were called by 3 parts seperatedly as well. These three batches of ASVs were subject to chimera removal using DADA2's "removeBimeraDenovo" fucntion with "consensus" option (meaning chimera were identified seperately for each sample without pooling the reads together first). ASVs from these 3 parts were then combined, and an additional chimera removal step, using DADA2's "removeBimeraDenovo" fucntion with "pooled" option (meaning the ASVs were pooled together from all samples and then chimera were identified) was performed to general a final ASV table.

Below you can view the plots generated during the error modle building step for the 3 individual sequencing parts:

Seqence Reads Part 1

Forward Read R1 Error Plot


Reverse Read R2 Error Plot

Seqence Reads Part 2

Forward Read R1 Error Plot


Reverse Read R2 Error Plot

Seqence Reads Part 3

Forward Read R1 Error Plot


Reverse Read R2 Error Plot

 

4. DADA2 Result Summary The table below shows the summary of the DADA2 analysis, tracking paired read counts of each samples for all the steps during DADA2 denoising process - including end-trimming (filtered), denoising (denoisedF, denoisedF), pair merging (merged) and chimera removal (nonchim).

Sample IDF5677.S001F5677.S002F5677.S003F5677.S004F5677.S005F5677.S006F5677.S007F5677.S008F5677.S009F5677.S010F5677.S011F5677.S012F5677.S013F5677.S014F5677.S015F5677.S016F5677.S017F5677.S018F5677.S019F5677.S020F5677.S021F5677.S022F5677.S023F5677.S024F5677.S025F5677.S026F5677.S027F5677.S028F5677.S029F5677.S030F5677.S031F5677.S032F5677.S033F5677.S034F5677.S035F5677.S036F5677.S037F5677.S038F5677.S039F5677.S040F5677.S041F5677.S042F5677.S043F5677.S044F5677.S045F5677.S046F5677.S047F5677.S048F5677.S049F5677.S050F5677.S051F5677.S052F5677.S053F5677.S054F5677.S055F5677.S056F5677.S057F5677.S058F5677.S059F5677.S060F5677.S061F5677.S062F5677.S063F5677.S064F5677.S065F5677.S066F5677.S067F5677.S068F5677.S069F5677.S070F5677.S071F5677.S072F5677.S073F5677.S074F5677.S075F5677.S076F5677.S077F5677.S078F5677.S079F5677.S080F5677.S081F5677.S082F5677.S083F5677.S084F5677.S085F5677.S086F5677.S087F5677.S088F5677.S089F5677.S090F5677.S091F5677.S092F5677.S093F5677.S094F5677.S095F5677.S096F5677.S097F5677.S098F5677.S099F5677.S100F5677.S101F5677.S102F5677.S103F5677.S104F5677.S105F5677.S106F5677.S107F5677.S108F5677.S109F5677.S110F5677.S111F5677.S112F5677.S113F5677.S114F5677.S115F5677.S116F5677.S117F5677.S118F5677.S119F5677.S120F5677.S121F5677.S122F5677.S123F5677.S124F5677.S125F5677.S126F5677.S127F5677.S128F5677.S129F5677.S130F5677.S131F5677.S132F5677.S133F5677.S134F5677.S135F5677.S136F5677.S137F5677.S138F5677.S139F5677.S140F5677.S141F5677.S142F5677.S143F5677.S144F5677.S145F5677.S146F5677.S147F5677.S148F5677.S149F5677.S150F5677.S151F5677.S152F5677.S153F5677.S154F5677.S155F5677.S156F5677.S157F5677.S158F5677.S159F5677.S160F5677.S161F5677.S162F5677.S163F5677.S164F5677.S165F5677.S166F5677.S167F5677.S168F5677.S169F5677.S170F5677.S171F5677.S172F5677.S173F5677.S174F5677.S175F5677.S176F5677.S177F5677.S178F5677.S179F5677.S180F5677.S181F5677.S182F5677.S183F5677.S184F5677.S185F5677.S186F5677.S187F5677.S188F5677.S189F5677.S190F5677.S191F5677.S192F5677.S193F5677.S194F5677.S195F5677.S196F5677.S197F5677.S198F5677.S199F5677.S200F5677.S201F5677.S202F5677.S203F5677.S204F5677.S205F5677.S206F5677.S207F5677.S208F5677.S209F5677.S210F5677.S211F5677.S212F5677.S213F5677.S214F5677.S215F5677.S216F5677.S217F5677.S218F5677.S219F5677.S220F5677.S221F5677.S222F5677.S223F5677.S224F5677.S225F5677.S226F5677.S227F5677.S228F5677.S229F5677.S230F5677.S231F5677.S232F5677.S233F5677.S234F5677.S235F5677.S236F5677.S237F5677.S238F5677.S239F5677.S240F5677.S241F5677.S242F5677.S243F5677.S244F5677.S245F5677.S246F5677.S247F5677.S248F5677.S249F5677.S250F5677.S251F5677.S252F5677.S253F5677.S254F5677.S255F5677.S256F5677.S257F5677.S258F5677.S259F5677.S260F5677.S261F5677.S262F5677.S263F5677.S264F5677.S265F5677.S266F5677.S267F5677.S268F5677.S269F5677.S270F5677.S271F5677.S272F5677.S273F5677.S274F5677.S275F5677.S276F5677.S277F5677.S278F5677.S279F5677.S280F5677.S281F5677.S282F5677.S283F5677.S284F5677.S285F5677.S286F5677.S287F5677.S288F5677.S289F5677.S290F5677.S291F5677.S292F5677.S293F5677.S294F5677.S295F5677.S296F5677.S297F5677.S298F5677.S299F5677.S300F5677.S301F5677.S302F5677.S303F5677.S304F5677.S305F5677.S306F5677.S307F5677.S308F5677.S309F5677.S310F5677.S311F5677.S312F5677.S313F5677.S314F5677.S315F5677.S316F5677.S317F5677.S318F5677.S319F5677.S320F5677.S321F5677.S322F5677.S323F5677.S324F5677.S325F5677.S326F5677.S327F5677.S328F5677.S329F5677.S330F5677.S331F5677.S332F5677.S333F5677.S334F5677.S335F5677.S336F5677.S337F5677.S338F5677.S339F5677.S340F5677.S341F5677.S342F5677.S343F5677.S344F5677.S345F5677.S346F5677.S347F5677.S348F5677.S349F5677.S350F5677.S351F5677.S352F5677.S353F5677.S354F5677.S355F5677.S356F5677.S357F5677.S358F5677.S359F5677.S360F5677.S361F5677.S362F5677.S363F5677.S364F5677.S365F5677.S366F5677.S367F5677.S368F5677.S369F5677.S370F5677.S371F5677.S372F5677.S373F5677.S374F5677.S375F5677.S376F5677.S377F5677.S378F5677.S379F5677.S380F5677.S381F5677.S382F5677.S383F5677.S384F5677.S385F5677.S386F5677.S387F5677.S388F5677.S389F5677.S390F5677.S391F5677.S392F5677.S393F5677.S394F5677.S395F5677.S396F5677.S397F5677.S398F5677.S399F5677.S400F5677.S401F5677.S402F5677.S403F5677.S404F5677.S405F5677.S406F5677.S407F5677.S408F5677.S409F5677.S410F5677.S411F5677.S412F5677.S413F5677.S414F5677.S415F5677.S416F5677.S417F5677.S418F5677.S419F5677.S420F5677.S421F5677.S422F5677.S423F5677.S424F5677.S425F5677.S426F5677.S427F5677.S428F5677.S429F5677.S430F5677.S431F5677.S432F5677.S433F5677.S434F5677.S435F5677.S436F5677.S437F5677.S438F5677.S439F5677.S440F5677.S441F5677.S442F5677.S443F5677.S444F5677.S445F5677.S446F5677.S447F5677.S448F5677.S449F5677.S450F5677.S451F5677.S452F5677.S453F5677.S454F5677.S455F5677.S456F5677.S457F5677.S458F5677.S459F5677.S460F5677.S461F5677.S462F5677.S463F5677.S464F5677.S465F5677.S466F5677.S467F5677.S468F5677.S469F5677.S470F5677.S471F5677.S472F5677.S473F5677.S474F5677.S475F5677.S476F5677.S477F5677.S478F5677.S479F5677.S480F5677.S481F5677.S482F5677.S483F5677.S484F5677.S485F5677.S486F5677.S487F5677.S488F5677.S489F5677.S490F5677.S491F5677.S492F5677.S493F5677.S494F5677.S495F5677.S496F5677.S497F5677.S498F5677.S499F5677.S500F5677.S501F5677.S502F5677.S503F5677.S504F5677.S505F5677.S506F5677.S507F5677.S508F5677.S509F5677.S510F5677.S511F5677.S512F5677.S513F5677.S514F5677.S515F5677.S516F5677.S517F5677.S518F5677.S519F5677.S520F5677.S521F5677.S522F5677.S523F5677.S524F5677.S525F5677.S526F5677.S527F5677.S528F5677.S529F5677.S530F5677.S531F5677.S532F5677.S533F5677.S534F5677.S535F5677.S536F5677.S537F5677.S538F5677.S539F5677.S540F5677.S541F5677.S542F5677.S543F5677.S544F5677.S545F5677.S546F5677.S547F5677.S548F5677.S549F5677.S550F5677.S551F5677.S552F5677.S553F5677.S554F5677.S555F5677.S556F5677.S557F5677.S558F5677.S559F5677.S560F5677.S561F5677.S562F5677.S563F5677.S564F5677.S565F5677.S566F5677.S567F5677.S568F5677.S569F5677.S570F5677.S571F5677.S572F5677.S573F5677.S574F5677.S575F5677.S576F5677.S577F5677.S578F5677.S579F5677.S580F5677.S581F5677.S582F5677.S583F5677.S584F5677.S585F5677.S586F5677.S587F5677.S588F5677.S589F5677.S590F5677.S591F5677.S592F5677.S593F5677.S594F5677.S595F5677.S596F5677.S597F5677.S598F5677.S599F5677.S600F5677.S601F5677.S602F5677.S603F5677.S604F5677.S605F5677.S606F5677.S607F5677.S608F5677.S609F5677.S610F5677.S611F5677.S612F5677.S613F5677.S614F5677.S615F5677.S616F5677.S617F5677.S618F5677.S619F5677.S620F5677.S621F5677.S622F5677.S623F5677.S624F5677.S625F5677.S626F5677.S627F5677.S628F5677.S629F5677.S630F5677.S631F5677.S632F5677.S633F5677.S634F5677.S635F5677.S636F5677.S637F5677.S638F5677.S639F5677.S640F5677.S641F5677.S642F5677.S643F5677.S644F5677.S645F5677.S646F5677.S647F5677.S648F5677.S649F5677.S650F5677.S651F5677.S652F5677.S653F5677.S654F5677.S655F5677.S656F5677.S657F5677.S658F5677.S659F5677.S660F5677.S661F5677.S662F5677.S663F5677.S664F5677.S665F5677.S666F5677.S667F5677.S668F5677.S669F5677.S670F5677.S671F5677.S672F5677.S673F5677.S674F5677.S675F5677.S676F5677.S677F5677.S678F5677.S679F5677.S680F5677.S681F5677.S682Row SumPercentage
input62,94771,41875,42046,49356,41755,34251,94155,66058,77659,24154,20066,82343,99557,57446,62143,33359,75257,37752,43654,74849,77946,67654,19451,72355,26957,67748,72156,73252,93765,17379,60261,63953,96252,68870,87354,80461,78264,23656,03753,67458,59664,19249,37551,52551,01658,35459,63738,45251,84250,08551,97250,49651,17756,85262,70157,13343,95059,99358,78557,20546,42159,10056,59167,47144,77660,85945,81867,42058,86755,14455,63062,15358,75352,29853,44642,07160,35237,61844,57757,14954,42461,67559,41177,51964,76753,11355,34548,94156,93759,73267,64745,91338,57240,47835,57737,26839,16050,77056,49654,77055,05162,59950,74451,39451,48555,93053,51763,81250,68744,67951,53460,41854,97155,32055,79758,63550,42763,99163,08854,19551,21458,55361,28266,21666,15243,86547,13754,02844,51046,17251,61951,10245,95247,94154,61452,96143,37048,75046,42061,00049,94156,43149,14247,82738,96959,99043,89354,09048,03957,77943,43540,45652,43246,61157,77950,52342,20352,75750,93638,80645,33040,35146,03947,09150,40563,80846,39140,45245,19242,35445,05743,40839,88650,23738,19942,58158,54746,17551,14344,94546,96355,26050,12851,06951,95141,57746,76151,93548,04243,81146,16160,08253,48249,58345,27041,94237,63047,00051,21939,49045,30244,94651,45845,56545,73450,67051,05244,86849,35749,08345,97952,04740,97343,00450,09253,20045,69156,09257,66647,40754,24361,93243,17142,77841,76144,54540,89344,41943,60539,31052,27749,02865,50445,99846,68652,52758,71052,54054,92138,78234,04939,32736,49361,01530,89248,51139,16858,49557,88049,50849,42851,98747,69564,01057,21539,39752,07749,38747,16546,49745,27148,37252,15842,07848,97349,71649,48642,80650,70136,04950,16343,45739,87244,15741,18746,79861,40438,25732,35639,02637,83951,69850,32447,37951,22248,29144,95849,45253,69453,99042,99142,96341,85944,27552,11339,93950,29449,76060,19838,22348,35947,50133,91945,06634,72639,09048,89446,87743,39354,18046,70546,14848,79755,48850,57943,34051,11240,46949,20346,45767,91845,24045,59043,32448,92837,80336,78534,14440,15338,76538,26464,14759,01443,56056,85646,62850,47151,58151,31753,88342,97949,14847,66960,50233,00832,23638,03938,38029,54333,49344,47249,71836,38637,39159,54342,32148,37841,05550,74040,74545,85041,84948,95645,91055,31563,84945,27155,98044,06345,59838,58352,09839,69639,83837,64443,10161,44534,64342,42533,13244,94637,78438,83246,08344,90445,58845,20183,91237,12637,24034,64851,17544,60623,97734,68129,38217,73845,16559,75125,84526,26732,04219,81018,45432,38630,84628,85932,83932,00167,16020,26837,19626,86623,50023,20027,26530,95239,74426,62223,24166,55522,00718,00732,45418,90937,21823,27339,02019,62118,98831,53454,99736,75012,03435,05524,41432,59838,41424,34724,92417,38830,25740,54064,32234,93030,73626,33531,44028,61916,16831,94828,91729,06330,31051,07737,89328,92124,20626,90634,67231,39332,02529,91230,86738,43755,92925,94134,54925,37622,16327,72531,95134,86534,94045,27625,30151,49021,95233,19329,15336,68625,32034,45648,03832,96629,16232,02352,28219,06417,10934,09442,66330,03627,11823,79022,20128,68724,80853,34628,55443,27235,30131,06023,74728,50828,22132,83738,29433,31152,50426,41745,36827,02025,07439,56233,49436,78027,81335,57224,79051,71340,30038,75137,38229,99427,11031,17141,24341,44432,20432,90858,89840,16138,23242,47629,49125,50220,51634,34034,13332,87243,21554,80236,05929,51839,03232,26533,10132,37340,58834,73636,51221,32060,67650,12434,94828,68426,19833,96529,63338,39233,37030,75826,20125,14856,84031,73433,98835,87237,13329,09832,59535,97038,01032,92238,97257,22427,38131,96133,80534,34945,98932,56823,19527,17330,92132,91268,36428,09357,05037,39735,39634,26931,16236,71940,36423,55930,37155,13728,73530,35431,24223,71443,00033,26324,92321,39833,70340,79755,55730,03126,33144,24035,98632,84630,45532,21515,94533,54737,71657,34427,97548,94930,06838,44841,04937,12336,89431,96728,46727,41950,17536,92433,68132,69527,78545,43620,30230,41234,34628,21528,77553,65822,85133,44041,94163,26749,32661,13458,20856,95659,92453,36747,38649,67950,73841,96456,72145,32654,37347,57453,98569,19160,45582,72956,09888,27059,81472,37548,26363,82347,73640,32445,02034,12640,64846,12782,97259,47956,03361,55652,77130,089,286100.00%
filtered62,00270,36774,32245,83855,56954,55751,15054,83857,88558,39453,44065,84543,35556,70845,92842,76758,96056,58751,72053,92449,13446,05653,40850,93854,52856,82347,99755,87552,15964,32378,42660,77853,21451,96569,81354,00260,89663,27555,24852,87157,68763,32248,66150,77550,30957,47158,81937,89251,07949,28951,13849,81650,47356,08561,78756,25243,38759,03957,93756,38945,78558,21855,73066,50744,14660,02845,18466,44958,02154,35254,78261,30057,90051,57152,63941,41559,43137,09243,94356,32253,70160,77458,49376,32063,82952,38654,57548,22856,12958,88166,61145,31237,96839,83335,05136,72638,55050,03355,61953,98454,26561,75250,02950,60150,70755,15252,72362,87949,95044,03350,79859,55654,21254,50754,94757,78249,69963,04662,20053,38250,47257,69560,38565,21365,24243,26546,48253,28843,90445,50750,84650,33445,32947,30953,85952,13542,76048,03845,74260,09249,23255,99448,75047,10238,68359,51743,61053,70247,69757,32243,08940,14552,06046,26456,94350,19441,84052,37150,55738,50544,98740,07145,63046,75350,04162,87046,04940,16944,85241,94644,74343,06339,63449,84537,93842,27257,72145,82850,75644,61546,53054,86249,72050,74851,60841,28146,43151,14847,71243,48345,82959,61253,10749,20944,89241,63837,39346,62850,50139,25344,96544,61851,10145,21745,37250,30450,63844,55848,97648,35745,68251,66140,63242,65649,73352,80745,38155,67357,29247,07253,48861,03842,85142,43541,48444,18940,64244,06543,26139,05851,90848,66964,49945,68546,30452,18658,24552,21854,53238,50533,76939,05336,19660,07930,69948,14438,86258,08657,40049,11849,07051,65847,31663,51256,33839,15251,67549,03146,79946,14545,00548,03751,79141,79248,59349,00649,10242,44350,34835,83149,77843,12139,56543,82140,85646,44060,47837,99432,18838,74837,54651,32549,96146,99250,84647,97544,65548,77953,31353,53042,67642,63741,55343,92251,76839,69349,92349,32859,29737,94948,02847,12533,68644,76834,49838,81648,51746,54343,06253,41346,34445,78048,45055,11950,17143,02250,73440,19548,82346,08166,90144,89445,28442,97848,56737,51136,51733,87339,82438,47538,03463,20358,19143,25056,38846,29450,09451,16050,89353,46842,71548,77147,29159,58432,78532,00137,76038,07429,33433,29144,16149,34936,11937,11058,71742,04848,00340,79850,34440,41945,47741,53948,57645,56954,90162,93344,94455,57243,74945,22138,34851,68139,42639,51937,40042,76060,56234,39342,09932,89244,61237,50338,48845,74044,54245,25744,84682,73036,87336,90034,40650,77444,28123,78134,38029,14917,59544,74758,89325,64126,06831,77419,64718,26732,14230,57128,65232,54731,74166,17120,11536,92326,63623,33523,03827,03230,71139,36126,36323,03365,51821,79917,83832,19118,77136,88423,09438,65819,42318,81331,24754,22736,40611,92734,75224,21832,29538,01024,13624,71717,25029,98439,94263,37634,56130,47126,08431,16728,38016,02731,69028,63328,79830,05350,33537,58128,65323,99526,67134,38831,12631,74129,66030,61138,11855,18025,71134,24825,17621,94627,49731,69034,52934,64844,89925,06450,72721,74932,93328,89336,35925,10834,15447,67732,65928,91031,71051,55518,90916,97633,80142,30229,75326,87323,62622,04628,41324,57452,61428,30442,92135,02730,76423,55128,24027,96832,55537,95233,01851,73126,17144,97326,78424,84039,21733,21936,47927,56135,27624,56150,96639,92738,44137,08629,73226,87830,88340,87841,08131,92632,62258,01039,81737,90842,13029,24525,29220,33534,04133,82032,57442,83853,95135,70029,25738,67231,99132,80732,11240,22534,47636,17721,14659,81549,40634,61028,45525,96833,72429,35438,06933,07430,45825,99024,95655,98731,44933,71735,53036,81928,83832,30535,65437,65232,60338,60656,43627,12831,69133,48034,09445,57732,29523,01026,94830,69132,65067,24727,84356,54137,04435,05233,98230,87136,41040,01123,33230,10554,32628,50030,08631,00023,47642,62132,95324,76521,24133,42640,47654,78029,77526,08143,87535,66532,60530,21031,94515,84333,24637,36756,57727,75348,49429,79138,12040,69536,81236,57631,71028,22427,14649,46736,55533,39632,41227,54545,08920,14630,15534,00927,95428,52852,92922,69133,14941,58062,34048,65060,28357,34756,15759,02852,58946,68248,99249,98441,35455,87744,61953,58546,87553,21168,18759,56981,44655,32187,01558,93771,24047,59762,94047,07539,66444,37033,69340,11445,51581,80758,56455,18960,67252,00629,768,43098.93%
denoisedF57,43166,09868,64341,67452,69250,67846,75250,78954,25054,58049,74561,30539,97951,78942,12938,49454,50753,75348,01349,70144,70842,26649,45046,43849,64152,24644,43852,37948,08359,53973,02856,20048,76946,87965,59550,40056,83257,79951,01848,42853,93858,71544,38846,92046,11653,34154,45234,14647,32145,53646,85945,89646,98052,16957,94852,79438,96154,22153,25251,68941,43155,43151,93762,99640,48856,13141,81363,37652,19050,08551,53457,29553,00448,28548,83937,61555,80032,99940,41753,38950,17457,43954,15072,20559,01747,33050,65643,96251,91555,41962,18341,91735,02437,06831,37434,07336,59845,69451,98550,53349,41657,15046,74446,51047,61750,72948,93159,07345,50239,75446,73155,39050,51750,41451,24154,65445,88159,18358,73049,72546,67053,44857,29561,94561,08239,63143,28049,42241,45141,85747,30447,13440,98544,56750,09248,15038,85544,90241,84156,99845,52753,68945,69743,19236,51956,41140,85251,30745,40954,17240,51537,86349,64743,76953,09547,47339,00649,62448,13035,77042,50037,30043,26943,99946,98358,83443,81637,97642,20439,42242,02940,32736,77947,16335,65539,62452,73843,02047,74641,64743,70451,96746,89347,82548,53838,63944,25247,50044,62040,89243,24456,19050,56546,62842,54539,11135,16244,36046,24836,91542,93842,52748,41341,94243,09147,64348,25541,68046,41844,34042,89348,42838,04040,37647,19349,80843,15253,55754,27744,29348,94155,94040,14840,09238,84342,62138,21341,78140,66437,11048,82446,12760,97543,10644,11148,82054,52348,83951,53836,30031,31636,84034,59255,83428,63345,88535,81954,32254,61046,20746,25348,89744,80560,11752,09636,74748,88946,68344,44144,11943,03345,57648,51539,14246,28443,84946,24539,09147,69033,88047,76440,17937,44641,25437,99343,27855,52835,75430,20336,35335,81448,08447,02043,86646,60744,98442,28244,00051,29950,30040,04040,72438,74641,40148,67637,56447,14846,03354,80335,57845,53845,21731,18642,55332,73636,54245,57843,97739,78249,21443,26442,75346,12852,25146,91140,00047,84037,60444,93442,63262,19742,45442,81340,31745,45335,32533,94131,43836,69536,40535,67357,87154,50040,68752,78643,59747,27948,21547,42550,73341,11045,49044,04754,73331,26529,87236,39535,51127,48931,61741,72447,09634,16134,52854,97339,61145,59137,99847,27437,91742,81638,92245,56642,92951,88059,15942,47252,36740,84842,87635,88249,57736,42137,71235,02640,28456,79432,15040,43230,57942,45535,64636,29843,42841,35542,41442,68777,91134,02235,46232,14048,23742,14122,70033,07628,47516,67143,88954,30224,86724,69231,02618,59217,32430,51629,46527,58331,29830,51661,89319,02035,86725,70522,26521,34725,74029,69938,25125,02321,85662,28320,72616,67830,91317,59935,91121,78937,53718,33717,85930,35650,06635,14410,94433,03723,00730,98536,60722,98223,55716,02428,42437,08159,20632,97829,07124,88230,01626,96114,87329,97226,89727,63428,63646,51735,87227,36222,49325,23733,75729,55830,59228,12729,13336,23251,40324,46332,96923,17921,19226,51930,11033,01232,76943,45724,03147,37820,31331,89027,30334,42523,98333,25146,57431,28527,77430,86148,42417,43116,28932,71440,66928,63025,57022,40621,10327,38723,29047,54027,04641,94033,52629,54122,21427,43626,68931,41136,75031,59548,62525,17243,63725,87323,69538,18731,68635,20826,66433,95123,55047,05038,31336,99135,82228,77525,62030,14840,25539,42530,71131,24853,41538,87336,55041,31727,52824,04519,29132,72732,51731,25840,72149,28634,09327,89137,22330,81631,19330,82138,62832,61834,86420,03754,82545,66733,47527,30325,03932,29527,87136,40132,00429,31424,75523,86551,68130,52632,14733,93235,21927,48130,86534,53236,32530,68037,47952,82226,11030,01432,50332,59644,86331,09321,68125,79929,36531,27362,40226,53455,20335,55433,79532,44329,71035,55238,49422,65829,23650,75127,62128,67030,14022,11841,33731,46723,04720,54331,94538,99451,21328,83125,12242,92233,67431,09028,72930,54014,87431,65336,28552,71326,90947,21028,87636,75139,56835,70735,01730,29426,35826,05045,33135,13631,68831,03325,81442,77818,99728,75732,64926,85827,02047,96521,67931,74539,32258,74944,98455,72253,31553,25555,00948,02543,14345,25346,68338,08851,98540,96349,72743,95349,45464,11355,64977,32651,02982,60354,59168,03143,87859,18744,02936,27541,13430,98237,40940,97276,59554,51348,97156,25847,02827,987,11693.01%
denoisedR58,61067,13770,68943,53053,52251,24348,91952,25855,15355,34950,62162,64641,39153,45943,40140,87056,15954,23848,98451,17346,58643,52650,21548,10251,97953,51545,38353,20749,23061,95674,95957,93749,95749,54267,06651,39858,06059,99352,68450,17854,95060,96846,14148,22947,91254,42656,11135,69848,13046,31348,75547,15047,88552,70158,84653,96141,29856,11054,92654,11142,88755,93052,80363,99941,99357,28343,13964,11055,63451,47652,40058,17054,98249,32249,72638,97356,94134,97441,49853,93450,69758,11655,73473,15260,29849,77951,36645,61153,13556,28763,57442,96536,02437,92633,15235,03137,10147,45752,80551,72851,79558,85747,88147,89048,30752,06250,44159,91447,42141,84548,15256,32451,99551,30852,55755,01947,18460,47559,81050,50848,36254,78557,95862,54261,70240,99843,99750,98341,99443,35948,11047,85543,17944,69951,54949,42540,48645,94043,68658,03946,52353,82046,11644,33536,48456,37641,20151,29045,56154,45340,79537,79549,47743,62654,03247,88039,48349,82748,14136,19742,74737,77543,39644,47347,25859,70443,62338,13942,81439,55242,39340,80837,50647,60935,86340,00854,81943,85048,39441,97543,91952,58147,41548,34448,69439,13244,14448,59245,01541,08743,86256,98650,40547,03242,41038,93234,92743,44447,80037,17542,58042,49347,94842,36143,20447,55948,15142,30446,76445,78242,87148,70438,47540,41247,32749,89243,54653,45354,29444,40551,05057,77540,24840,13139,09442,11838,66441,68540,92637,29349,03946,04062,09843,37143,87449,45054,98549,16851,31336,58131,70037,15234,56956,76229,05346,00836,93754,99554,65847,29246,27848,97744,76860,55453,64637,02948,97546,67344,91143,91342,93845,59349,03839,97446,20146,31746,37439,90647,67033,71347,23440,76237,89041,56238,37443,97357,13235,57730,33136,06435,95749,02947,53244,19248,12545,49042,22746,31551,06050,92040,26540,82539,06842,05048,99537,75547,19046,89356,41835,49045,41844,95731,91442,72232,19535,90445,42744,53840,28451,22843,63443,67045,97552,02347,17940,70848,26938,01145,93043,66163,78242,39142,75140,27646,43335,79634,36331,66337,73336,47435,38559,70355,73140,51153,29444,27147,38048,42248,46550,83040,72645,47244,68656,44631,33629,82636,33336,50227,78831,85542,14947,08634,29634,92456,30740,13445,84338,14447,81638,17143,01139,18945,55443,54652,13960,21242,44252,58041,50443,42236,18049,54737,23637,89435,26740,41658,25032,48040,16030,79342,36336,04236,43143,34241,74042,93742,55579,26834,62535,31732,69448,58442,03922,93333,14628,42016,60843,62456,48924,95425,09631,00118,67617,40730,76729,72827,67431,32230,82362,84319,28635,85025,74322,46822,06326,05429,80738,26725,20822,07962,81321,02717,11731,16817,96335,84322,19837,59318,49818,00130,47551,41935,23811,36933,46223,28130,95636,44623,09423,71316,47328,81738,13760,59233,19529,39025,10630,08127,31215,23630,53827,48927,95628,82147,39235,96927,64222,93725,63933,46829,98630,76628,71529,41336,58452,66024,76733,24724,20221,32926,50430,21632,95733,73943,56324,13247,68720,85032,17527,57034,67024,19333,19546,35031,64227,80330,86249,30618,19116,35632,59640,81328,80925,60722,95021,33527,42623,42249,35227,40441,81433,69329,57922,72627,28526,90431,62336,69232,00149,30625,18343,74026,08123,79737,84632,13534,99026,55633,93123,75647,69238,71937,19335,80628,66425,93629,76339,98939,84030,80731,40755,21838,59536,38141,08827,72924,37919,44133,02632,43931,41441,17750,64634,47228,20437,17730,70531,54230,90138,81533,00134,96920,48356,83947,16133,53727,49325,03632,32428,16736,60132,07229,34724,97024,18053,00430,46132,58734,39535,44727,59831,07534,51636,64131,33137,39054,46526,11430,57032,22433,16044,55731,23922,13725,94129,38831,43264,08526,79155,09635,80634,00032,97829,71735,46638,80822,65829,18651,59927,49629,26129,99222,55141,35531,55923,89020,58932,20739,29651,77228,79825,25142,94633,97631,21529,17830,98615,03131,70736,32554,05426,86147,29728,80037,04139,61335,70034,98030,40927,06026,30746,73735,31632,08331,12026,53343,79819,53928,97532,76026,98227,11650,09922,04731,83639,43559,85846,82856,57354,30353,97556,22150,02344,08946,53147,29139,52453,20342,06750,94044,87050,70265,16257,13378,26752,77283,45655,40068,36745,08560,18944,80337,81642,20532,19337,98843,57678,36555,85952,24757,92049,23628,383,86794.33%
merged55,14864,05666,40540,41051,37248,52145,65649,19152,33652,55947,90559,37138,96049,86840,63937,58752,84952,20146,29447,97843,20540,75747,51044,80848,19150,18842,66750,68546,41358,12770,99854,49246,65345,60264,01948,82555,02955,80249,44346,80752,17257,35542,86345,29744,57651,32852,74433,00245,51043,73945,70344,36545,28550,08756,05751,38237,84552,46551,54950,36739,64953,91250,01161,50239,16554,27940,54161,86450,93948,32049,84555,10551,19046,96947,02536,11354,33231,77538,98651,68948,09755,67452,44770,21656,82845,80548,57542,34149,94053,81860,30240,34233,80035,96330,28032,98635,61844,05250,21049,06847,84255,37045,34344,72546,12448,75947,59357,17344,03538,49145,23253,38749,11448,42349,72852,97044,49457,53557,27248,01145,40451,68755,78360,25958,77138,29541,79348,07640,25140,50545,54545,53439,74742,88848,62546,52137,48843,54540,60555,71243,78052,32143,87041,42735,20454,18539,20749,60243,96152,18439,00636,19647,91841,90051,17145,87737,32547,78646,41034,30441,10535,83041,73442,51245,00356,80942,18036,63040,88237,77940,59038,79135,39745,71534,29638,08351,15441,81146,14739,96141,85750,48645,30646,16446,59337,17742,58845,96542,72739,10441,88254,33848,64545,10240,77237,15233,41241,91144,63635,52441,34740,96746,13140,05941,71745,81646,59040,22644,93242,78740,88146,34736,65338,81945,56047,60041,93051,97552,07642,46847,51953,97238,36838,50737,23641,14636,84740,18439,02735,91546,95944,32559,46341,64842,34947,01052,24946,65449,26734,96729,82135,56333,43453,68027,46644,38434,50052,28952,69545,11244,34346,89443,12858,26650,47635,29047,10845,04343,27642,57841,50543,84046,58638,01844,76342,34644,48537,48445,88832,23846,00838,68536,40539,72636,36741,65753,38034,05628,83334,44534,84546,55945,46342,00344,84343,28940,55842,62149,78648,50538,34339,56836,98540,15746,62736,10345,16544,45153,08433,77843,73943,70830,05041,09830,93034,38643,46042,78437,91447,90941,47041,42844,43649,88844,88738,52546,08436,19942,95541,09260,25040,64640,79438,40144,02834,26332,57129,95635,42935,07933,66455,63153,02138,69850,68142,35445,43146,40745,92748,84439,66943,16542,27552,99130,25628,31135,39734,47226,37130,54340,45145,55332,91933,00353,56838,27844,02836,04445,48636,48741,10737,40543,49841,57050,01757,42140,72750,22439,34441,68234,56348,09734,94836,58233,51938,64355,30730,81539,07029,14740,83634,67234,92441,66239,39940,92141,06975,64932,57134,39731,01546,71940,58821,99132,07527,87815,85942,95152,83824,31123,89630,36917,82816,62429,38128,77926,88730,27229,85059,66318,37634,95324,94221,60920,61024,94828,94337,33624,06321,09360,52020,10216,08830,08816,90835,05021,03536,66917,64117,20429,68448,24834,18410,55432,00222,24129,88435,35022,13622,77815,39427,46636,08557,55131,94828,18724,09529,12226,09914,23329,03525,98126,97227,59744,79234,55726,54921,64924,39632,98328,64229,82127,36728,13834,94549,77823,69732,18122,43220,71725,68328,85631,68732,02142,34123,23845,36119,57631,26426,17733,03623,24232,41945,45130,47826,87030,16846,99416,84615,79631,71539,40327,84624,55421,88220,54626,55122,33745,51126,33041,01532,41028,51121,56726,65525,81230,69635,70030,75546,99924,39542,65225,29722,85937,10930,85833,95025,79732,85922,88644,94337,30135,93934,74127,88724,84329,21939,47338,38229,78730,24551,84637,90635,25640,46526,25923,29118,53031,88431,34630,26139,35147,11533,13027,02436,01029,73630,11929,75137,47831,38233,83619,51653,23044,45732,61626,50224,24931,14426,90235,17631,20528,35423,92723,23749,91629,72331,20932,95534,09226,42229,86333,55935,47529,62036,44751,69225,28029,13131,40831,84243,97030,22820,96924,99328,29830,28360,36525,74053,96634,56632,95531,61928,73834,77537,47322,12028,47849,07326,85328,02229,25421,34940,26230,32722,33519,99830,92938,05349,52128,01224,39942,20632,26029,93027,89229,76414,20230,35435,37851,25526,18846,21828,04435,85638,64234,79133,69829,22725,45725,42143,58634,10430,57529,94324,98841,73418,51927,73831,60826,06925,80946,32621,21230,63737,49857,11543,92853,29151,31151,76553,30146,54841,56243,69044,92836,90550,26439,23948,18842,66948,07762,22554,20475,26949,53280,30652,25266,21142,36457,44342,59535,14339,72230,08036,09139,79574,54052,97747,27754,54745,44327,046,30489.89%
nonchim25,87532,67928,48125,48923,45120,71522,82621,52422,31324,35323,36527,78319,93324,30717,92818,30125,59828,59921,48318,13423,54621,74824,47421,24922,85925,92920,58118,71018,82626,13932,76922,28322,56721,03727,75323,68123,52425,92024,20721,68623,41631,39520,33020,82320,64324,11421,16523,80626,00922,41018,10919,45819,62721,57723,32628,38721,44323,51223,58822,32322,00925,92124,40929,41019,76530,13719,45326,69927,27125,14221,91225,24324,51424,36121,34616,99825,72416,40120,49623,72425,16226,55221,54634,44026,66022,44224,93523,89825,19921,81724,72119,06415,05017,12515,65315,16718,40223,20719,01422,21223,32724,10820,26820,34323,15620,46023,32727,28221,78719,27328,98624,22926,18823,50919,65325,46018,99330,04036,92622,28722,86023,30129,67630,35423,48922,99920,68321,07016,50618,01020,83720,58617,75121,20224,23520,47918,95721,31423,43118,69217,02131,73421,20619,91216,11724,43922,97119,55116,72422,00117,80116,15419,63719,63819,57719,62917,94719,00520,16316,66116,13717,67717,21820,48223,70126,18618,46912,92514,08415,71320,76616,98218,24319,14816,24616,93624,48015,87319,76923,66021,75524,56817,73920,66222,78021,48918,29820,21821,47618,07516,90624,79019,61317,38117,21117,36617,62815,58621,00316,30118,84717,85920,21318,36820,44425,66217,70918,42722,51417,09822,22222,40516,67716,16219,66922,54115,40424,73223,97719,79725,57627,42219,19517,80717,56024,07017,20819,83316,59414,69319,63321,74925,42620,10220,45020,26026,40022,23623,86215,41815,50214,71612,71222,06313,58220,47317,99722,33123,26821,14423,83520,40517,61226,53525,92616,21918,79421,52423,00624,44720,86522,11221,42717,57320,09720,31018,85519,32422,70317,07322,52919,29816,76617,27415,01820,62824,42517,23113,19215,17619,39421,03617,83919,01724,41220,74120,18920,35327,77422,87719,83814,34619,38220,29120,67216,57019,39421,74227,08716,10419,99016,92613,87016,24115,11615,92418,23220,79717,84718,86621,25617,43317,49626,41419,68216,81319,65218,10221,53220,44128,47316,88920,09618,44120,46214,97113,37016,97216,93017,21720,13325,24622,28220,45025,42918,63221,00421,61022,03118,13023,03123,95620,06221,45213,00814,52115,74413,94911,77911,75420,66620,90014,40317,94026,39317,90318,46117,07419,97717,52018,74915,34122,14017,31022,60830,06517,73822,05217,74227,90916,70827,65218,57722,96515,09316,51225,72215,35821,02914,48218,11621,55220,26522,80518,79417,52618,19346,64216,14624,27720,82222,73819,67410,05013,82818,2718,21130,57123,90812,41911,98412,7198,9908,10915,23013,2929,05514,56615,58430,8109,25418,1288,35012,18811,87711,34112,00016,84011,7389,21626,6017,8678,35012,5469,00317,98911,71116,0057,5027,14611,80621,87414,7715,74414,02010,15816,79314,8498,6469,0328,16012,40814,01822,77711,80111,1749,84211,60912,1407,67113,09510,83412,09113,80424,06415,06311,37211,68012,26817,60913,57012,22012,98612,27216,96323,19310,15613,03410,7428,93312,98313,90414,93613,44118,7939,87321,04810,15616,30412,42013,2209,72515,38817,49113,11413,43511,10325,1348,0915,84815,43916,48810,71612,6698,0218,14411,23311,02124,56811,62416,31814,44614,3889,47313,30710,92410,03014,16513,31319,08412,69618,98711,94711,25616,48112,43013,49310,52412,4968,50119,29114,30914,38515,4819,52211,43212,98716,42316,53311,70213,08525,71818,57915,51117,74213,5229,8559,20512,13319,61113,01719,83325,99714,76312,34317,11211,77013,71112,93817,85717,14016,4618,68922,62021,89211,95411,38911,76512,71613,50416,05514,57313,56410,05310,11920,27317,27812,24714,26014,47510,79012,71017,08917,63415,15813,83627,41612,82212,96712,68612,82821,42113,3399,37110,78515,12113,40426,24911,24820,79613,91713,98815,43611,37518,08915,2367,68915,91116,38014,92610,74212,78511,23017,82214,67112,9268,58215,33323,01027,48112,13911,19230,03416,26016,05813,33913,6117,92513,46118,19321,69013,24620,35212,71016,22820,36617,88416,70515,75112,9179,16022,89914,75914,69015,54813,31521,95610,48012,64716,10411,75912,64926,9547,84414,50018,92123,84323,99831,03328,35027,64123,92920,06821,37526,84427,19516,69925,45621,96122,52817,03928,91333,91824,80144,84024,79646,38525,66933,13924,28428,34718,67616,74619,27319,85816,46622,22235,85523,46827,08727,90122,45612,764,16642.42%

This table can be downloaded as an Excel table below:

 

5. DADA2 Amplicon Sequence Variants (ASVs). A total of 40270 unique merged and chimera-free ASV sequences were identified, and their corresponding read counts for each sample are available in the "ASV Read Count Table" with rows for the ASV sequences and columns for sample. This read count table can be used for microbial profile comparison among different samples and the sequences provided in the table can be used to taxonomy assignment.

 

The table can be downloaded from this link:

 
 

Sample Meta Information

#SampleIDSamplesVisitWeekSubjectPlaque NoTobacco KeyGroupSubgroup
F5677.S157F5677.S157Visit 912 WeeksSubject 26001Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S161F5677.S161Visit 912 WeeksSubject 26008Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S164F5677.S164Visit 912 WeeksSubject 26013Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S165F5677.S165Visit 912 WeeksSubject 26014Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S166F5677.S166Visit 912 WeeksSubject 26015Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S167F5677.S167Visit 912 WeeksSubject 26016Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S168F5677.S168Visit 912 WeeksSubject 26018Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S169F5677.S169Visit 912 WeeksSubject 26019Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S170F5677.S170Visit 912 WeeksSubject 26020Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S174F5677.S174Visit 912 WeeksSubject 26030Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S177F5677.S177Visit 912 WeeksSubject 26033Plaque 1A12 Weeks.A.Plaque 1None 12 Weeks P1
F5677.S178F5677.S178Visit 912 WeeksSubject 26037Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S179F5677.S179Visit 912 WeeksSubject 26040Plaque 1A12 Weeks.A.Plaque 1None 12 Weeks P1
F5677.S180F5677.S180Visit 912 WeeksSubject 26042Plaque 1A12 Weeks.A.Plaque 1None 12 Weeks P1
F5677.S181F5677.S181Visit 912 WeeksSubject 26044Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S183F5677.S183Visit 912 WeeksSubject 26048Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S187F5677.S187Visit 912 WeeksSubject 26055Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S188F5677.S188Visit 912 WeeksSubject 26059Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S189F5677.S189Visit 912 WeeksSubject 26061Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S190F5677.S190Visit 912 WeeksSubject 26062Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S193F5677.S193Visit 912 WeeksSubject 26067Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S201F5677.S201Visit 912 WeeksSubject 26085Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S203F5677.S203Visit 912 WeeksSubject 26087Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S207F5677.S207Visit 912 WeeksSubject 26093Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S208F5677.S208Visit 912 WeeksSubject 26094Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S209F5677.S209Visit 912 WeeksSubject 26095Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S210F5677.S210Visit 912 WeeksSubject 26097Plaque 1A12 Weeks.A.Plaque 1None 12 Weeks P1
F5677.S211F5677.S211Visit 912 WeeksSubject 26099Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S215F5677.S215Visit 912 WeeksSubject 26105Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S216F5677.S216Visit 912 WeeksSubject 26106Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S219F5677.S219Visit 912 WeeksSubject 26114Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S220F5677.S220Visit 912 WeeksSubject 26115Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S221F5677.S221Visit 912 WeeksSubject 26116Plaque 1A12 Weeks.A.Plaque 1OSS 12 Weeks P1
F5677.S226F5677.S226Visit 912 WeeksSubject 26125Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S227F5677.S227Visit 912 WeeksSubject 26126Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S229F5677.S229Visit 912 WeeksSubject 26131Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S231F5677.S231Visit 912 WeeksSubject 26140Plaque 1A12 Weeks.A.Plaque 1None 12 Weeks P1
F5677.S232F5677.S232Visit 912 WeeksSubject 26142Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S236F5677.S236Visit 912 WeeksSubject 26147Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
F5677.S243F5677.S243Visit 912 WeeksSubject 26157Plaque 1A12 Weeks.A.Plaque 1DUS 12 Weeks P1
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F5677.S588F5677.S588Visit 1524 WeeksSubject 26160Plaque 1A24 Weeks.A.Plaque 1DUS 24 Weeks P1
F5677.S589F5677.S589Visit 1524 WeeksSubject 26161Plaque 1A24 Weeks.A.Plaque 1DUS 24 Weeks P1
F5677.S590F5677.S590Visit 1524 WeeksSubject 26162Plaque 1A24 Weeks.A.Plaque 1DUS 24 Weeks P1
F5677.S591F5677.S591Visit 1524 WeeksSubject 26163Plaque 1A24 Weeks.A.Plaque 1None 24 Weeks P1
F5677.S592F5677.S592Visit 1524 WeeksSubject 26165Plaque 1A24 Weeks.A.Plaque 1DUS 24 Weeks P1
F5677.S593F5677.S593Visit 1524 WeeksSubject 26167Plaque 1A24 Weeks.A.Plaque 1DUS 24 Weeks P1
F5677.S597F5677.S597Visit 1524 WeeksSubject 26177Plaque 1A24 Weeks.A.Plaque 1DUS 24 Weeks P1
F5677.S598F5677.S598Visit 1524 WeeksSubject 26001Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S602F5677.S602Visit 1524 WeeksSubject 26008Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S605F5677.S605Visit 1524 WeeksSubject 26013Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S606F5677.S606Visit 1524 WeeksSubject 26014Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S607F5677.S607Visit 1524 WeeksSubject 26015Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S608F5677.S608Visit 1524 WeeksSubject 26016Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S609F5677.S609Visit 1524 WeeksSubject 26018Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S610F5677.S610Visit 1524 WeeksSubject 26019Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S611F5677.S611Visit 1524 WeeksSubject 26020Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S614F5677.S614Visit 1524 WeeksSubject 26030Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S617F5677.S617Visit 1524 WeeksSubject 26033Plaque 2A24 Weeks.A.Plaque 2None 24 Weeks P2
F5677.S618F5677.S618Visit 1524 WeeksSubject 26037Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S619F5677.S619Visit 1524 WeeksSubject 26040Plaque 2A24 Weeks.A.Plaque 2None 24 Weeks P2
F5677.S620F5677.S620Visit 1524 WeeksSubject 26044Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S622F5677.S622Visit 1524 WeeksSubject 26048Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S626F5677.S626Visit 1524 WeeksSubject 26055Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S627F5677.S627Visit 1524 WeeksSubject 26059Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S628F5677.S628Visit 1524 WeeksSubject 26061Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S629F5677.S629Visit 1524 WeeksSubject 26062Plaque 2A24 Weeks.A.Plaque 2None 24 Weeks P2
F5677.S631F5677.S631Visit 1524 WeeksSubject 26067Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S639F5677.S639Visit 1524 WeeksSubject 26085Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S641F5677.S641Visit 1524 WeeksSubject 26087Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S645F5677.S645Visit 1524 WeeksSubject 26094Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S646F5677.S646Visit 1524 WeeksSubject 26095Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S647F5677.S647Visit 1524 WeeksSubject 26099Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S650F5677.S650Visit 1524 WeeksSubject 26105Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S651F5677.S651Visit 1524 WeeksSubject 26106Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S654F5677.S654Visit 1524 WeeksSubject 26116Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S658F5677.S658Visit 1524 WeeksSubject 26126Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S659F5677.S659Visit 1524 WeeksSubject 26131Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S661F5677.S661Visit 1524 WeeksSubject 26140Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S665F5677.S665Visit 1524 WeeksSubject 26147Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S672F5677.S672Visit 1524 WeeksSubject 26157Plaque 2A24 Weeks.A.Plaque 2OSS 24 Weeks P2
F5677.S673F5677.S673Visit 1524 WeeksSubject 26160Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S674F5677.S674Visit 1524 WeeksSubject 26161Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S675F5677.S675Visit 1524 WeeksSubject 26162Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S676F5677.S676Visit 1524 WeeksSubject 26163Plaque 2A24 Weeks.A.Plaque 2None 24 Weeks P2
F5677.S677F5677.S677Visit 1524 WeeksSubject 26165Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S678F5677.S678Visit 1524 WeeksSubject 26167Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S682F5677.S682Visit 1524 WeeksSubject 26177Plaque 2A24 Weeks.A.Plaque 2DUS 24 Weeks P2
F5677.S514F5677.S514Visit 1524 WeeksSubject 26003Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S515F5677.S515Visit 1524 WeeksSubject 26005Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S516F5677.S516Visit 1524 WeeksSubject 26006Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S518F5677.S518Visit 1524 WeeksSubject 26009Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S519F5677.S519Visit 1524 WeeksSubject 26012Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S527F5677.S527Visit 1524 WeeksSubject 26027Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S528F5677.S528Visit 1524 WeeksSubject 26029Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S530F5677.S530Visit 1524 WeeksSubject 26031Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S531F5677.S531Visit 1524 WeeksSubject 26032Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S536F5677.S536Visit 1524 WeeksSubject 26046Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S538F5677.S538Visit 1524 WeeksSubject 26050Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S539F5677.S539Visit 1524 WeeksSubject 26052Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S540F5677.S540Visit 1524 WeeksSubject 26054Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S545F5677.S545Visit 1524 WeeksSubject 26066Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S547F5677.S547Visit 1524 WeeksSubject 26072Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S548F5677.S548Visit 1524 WeeksSubject 26073Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S549F5677.S549Visit 1524 WeeksSubject 26079Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S550F5677.S550Visit 1524 WeeksSubject 26080Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S551F5677.S551Visit 1524 WeeksSubject 26081Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S552F5677.S552Visit 1524 WeeksSubject 26083Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S553F5677.S553Visit 1524 WeeksSubject 26084Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S555F5677.S555Visit 1524 WeeksSubject 26086Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S557F5677.S557Visit 1524 WeeksSubject 26089Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S558F5677.S558Visit 1524 WeeksSubject 26090Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S559F5677.S559Visit 1524 WeeksSubject 26091Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S563F5677.S563Visit 1524 WeeksSubject 26102Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S564F5677.S564Visit 1524 WeeksSubject 26103Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S567F5677.S567Visit 1524 WeeksSubject 26109Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S568F5677.S568Visit 1524 WeeksSubject 26111Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S570F5677.S570Visit 1524 WeeksSubject 26118Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S571F5677.S571Visit 1524 WeeksSubject 26121Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S572F5677.S572Visit 1524 WeeksSubject 26123Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S575F5677.S575Visit 1524 WeeksSubject 26132Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S577F5677.S577Visit 1524 WeeksSubject 26143Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S578F5677.S578Visit 1524 WeeksSubject 26144Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S579F5677.S579Visit 1524 WeeksSubject 26146Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S581F5677.S581Visit 1524 WeeksSubject 26148Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S582F5677.S582Visit 1524 WeeksSubject 26149Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S583F5677.S583Visit 1524 WeeksSubject 26151Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S584F5677.S584Visit 1524 WeeksSubject 26152Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S585F5677.S585Visit 1524 WeeksSubject 26154Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S586F5677.S586Visit 1524 WeeksSubject 26155Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S594F5677.S594Visit 1524 WeeksSubject 26168Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S595F5677.S595Visit 1524 WeeksSubject 26170Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S596F5677.S596Visit 1524 WeeksSubject 26175Plaque 1B24 Weeks.B.Plaque 1Smoker 24 Weeks P1
F5677.S599F5677.S599Visit 1524 WeeksSubject 26003Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S600F5677.S600Visit 1524 WeeksSubject 26005Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S601F5677.S601Visit 1524 WeeksSubject 26006Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S603F5677.S603Visit 1524 WeeksSubject 26009Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S604F5677.S604Visit 1524 WeeksSubject 26012Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S612F5677.S612Visit 1524 WeeksSubject 26027Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S613F5677.S613Visit 1524 WeeksSubject 26029Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S615F5677.S615Visit 1524 WeeksSubject 26031Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S616F5677.S616Visit 1524 WeeksSubject 26032Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S621F5677.S621Visit 1524 WeeksSubject 26046Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S623F5677.S623Visit 1524 WeeksSubject 26050Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S624F5677.S624Visit 1524 WeeksSubject 26052Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S625F5677.S625Visit 1524 WeeksSubject 26054Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S630F5677.S630Visit 1524 WeeksSubject 26066Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S632F5677.S632Visit 1524 WeeksSubject 26072Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S633F5677.S633Visit 1524 WeeksSubject 26073Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S634F5677.S634Visit 1524 WeeksSubject 26079Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S635F5677.S635Visit 1524 WeeksSubject 26080Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S636F5677.S636Visit 1524 WeeksSubject 26081Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S637F5677.S637Visit 1524 WeeksSubject 26083Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S638F5677.S638Visit 1524 WeeksSubject 26084Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S640F5677.S640Visit 1524 WeeksSubject 26086Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S642F5677.S642Visit 1524 WeeksSubject 26089Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S643F5677.S643Visit 1524 WeeksSubject 26090Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S644F5677.S644Visit 1524 WeeksSubject 26091Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S648F5677.S648Visit 1524 WeeksSubject 26102Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S649F5677.S649Visit 1524 WeeksSubject 26103Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S652F5677.S652Visit 1524 WeeksSubject 26109Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S653F5677.S653Visit 1524 WeeksSubject 26111Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S655F5677.S655Visit 1524 WeeksSubject 26118Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S656F5677.S656Visit 1524 WeeksSubject 26121Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S657F5677.S657Visit 1524 WeeksSubject 26123Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S660F5677.S660Visit 1524 WeeksSubject 26132Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S662F5677.S662Visit 1524 WeeksSubject 26143Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S663F5677.S663Visit 1524 WeeksSubject 26144Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S664F5677.S664Visit 1524 WeeksSubject 26146Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S666F5677.S666Visit 1524 WeeksSubject 26148Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S667F5677.S667Visit 1524 WeeksSubject 26149Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S668F5677.S668Visit 1524 WeeksSubject 26151Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S669F5677.S669Visit 1524 WeeksSubject 26152Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S670F5677.S670Visit 1524 WeeksSubject 26154Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S671F5677.S671Visit 1524 WeeksSubject 26155Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S679F5677.S679Visit 1524 WeeksSubject 26168Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S680F5677.S680Visit 1524 WeeksSubject 26170Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S681F5677.S681Visit 1524 WeeksSubject 26175Plaque 2B24 Weeks.B.Plaque 2Smoker 24 Weeks P2
F5677.S001F5677.S001Visit 3BaselineSubject 26001Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S002F5677.S002Visit 3BaselineSubject 26002Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S007F5677.S007Visit 3BaselineSubject 26007Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S008F5677.S008Visit 3BaselineSubject 26008Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S010F5677.S010Visit 3BaselineSubject 26010Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S011F5677.S011Visit 3BaselineSubject 26011Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S013F5677.S013Visit 3BaselineSubject 26013Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S014F5677.S014Visit 3BaselineSubject 26014Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S015F5677.S015Visit 3BaselineSubject 26015Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S016F5677.S016Visit 3BaselineSubject 26016Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S017F5677.S017Visit 3BaselineSubject 26017Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S018F5677.S018Visit 3BaselineSubject 26018Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S019F5677.S019Visit 3BaselineSubject 26019Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S020F5677.S020Visit 3BaselineSubject 26020Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S022F5677.S022Visit 3BaselineSubject 26022Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S023F5677.S023Visit 3BaselineSubject 26023Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S024F5677.S024Visit 3BaselineSubject 26024Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S026F5677.S026Visit 3BaselineSubject 26028Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S028F5677.S028Visit 3BaselineSubject 26030Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S031F5677.S031Visit 3BaselineSubject 26033Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S032F5677.S032Visit 3BaselineSubject 26034Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S033F5677.S033Visit 3BaselineSubject 26035Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S034F5677.S034Visit 3BaselineSubject 26036Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S035F5677.S035Visit 3BaselineSubject 26037Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S036F5677.S036Visit 3BaselineSubject 26038Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S037F5677.S037Visit 3BaselineSubject 26039Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S038F5677.S038Visit 3BaselineSubject 26040Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S039F5677.S039Visit 3BaselineSubject 26042Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S040F5677.S040Visit 3BaselineSubject 26043Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S041F5677.S041Visit 3BaselineSubject 26044Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S042F5677.S042Visit 3BaselineSubject 26045Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S045F5677.S045Visit 3BaselineSubject 26048Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S049F5677.S049Visit 3BaselineSubject 26055Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S050F5677.S050Visit 3BaselineSubject 26056Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S053F5677.S053Visit 3BaselineSubject 26059Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S054F5677.S054Visit 3BaselineSubject 26061Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S055F5677.S055Visit 3BaselineSubject 26062Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S056F5677.S056Visit 3BaselineSubject 26063Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S057F5677.S057Visit 3BaselineSubject 26064Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S060F5677.S060Visit 3BaselineSubject 26067Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S061F5677.S061Visit 3BaselineSubject 26068Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S062F5677.S062Visit 3BaselineSubject 26070Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S063F5677.S063Visit 3BaselineSubject 26071Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S066F5677.S066Visit 3BaselineSubject 26075Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S068F5677.S068Visit 3BaselineSubject 26077Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S073F5677.S073Visit 3BaselineSubject 26082Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S076F5677.S076Visit 3BaselineSubject 26085Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S078F5677.S078Visit 3BaselineSubject 26087Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S079F5677.S079Visit 3BaselineSubject 26088Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S083F5677.S083Visit 3BaselineSubject 26092Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S084F5677.S084Visit 3BaselineSubject 26093Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S085F5677.S085Visit 3BaselineSubject 26094Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S086F5677.S086Visit 3BaselineSubject 26095Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S087F5677.S087Visit 3BaselineSubject 26096Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S088F5677.S088Visit 3BaselineSubject 26097Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S089F5677.S089Visit 3BaselineSubject 26098Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S090F5677.S090Visit 3BaselineSubject 26099Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S095F5677.S095Visit 3BaselineSubject 26104Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S096F5677.S096Visit 3BaselineSubject 26105Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S097F5677.S097Visit 3BaselineSubject 26106Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S098F5677.S098Visit 3BaselineSubject 26108Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S102F5677.S102Visit 3BaselineSubject 26113Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S103F5677.S103Visit 3BaselineSubject 26114Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S104F5677.S104Visit 3BaselineSubject 26115Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S105F5677.S105Visit 3BaselineSubject 26116Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S107F5677.S107Visit 3BaselineSubject 26119Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S110F5677.S110Visit 3BaselineSubject 26122Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S113F5677.S113Visit 3BaselineSubject 26125Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S114F5677.S114Visit 3BaselineSubject 26126Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S115F5677.S115Visit 3BaselineSubject 26127Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S117F5677.S117Visit 3BaselineSubject 26131Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S119F5677.S119Visit 3BaselineSubject 26134Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S120F5677.S120Visit 3BaselineSubject 26135Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S121F5677.S121Visit 3BaselineSubject 26136Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S122F5677.S122Visit 3BaselineSubject 26140Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S123F5677.S123Visit 3BaselineSubject 26141Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S124F5677.S124Visit 3BaselineSubject 26142Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S127F5677.S127Visit 3BaselineSubject 26145Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S129F5677.S129Visit 3BaselineSubject 26147Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S137F5677.S137Visit 3BaselineSubject 26157Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S138F5677.S138Visit 3BaselineSubject 26158Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S139F5677.S139Visit 3BaselineSubject 26159Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S140F5677.S140Visit 3BaselineSubject 26160Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S141F5677.S141Visit 3BaselineSubject 26161Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S142F5677.S142Visit 3BaselineSubject 26162Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S143F5677.S143Visit 3BaselineSubject 26163Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S145F5677.S145Visit 3BaselineSubject 26165Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S146F5677.S146Visit 3BaselineSubject 26166Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S147F5677.S147Visit 3BaselineSubject 26167Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S151F5677.S151Visit 3BaselineSubject 26173Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S155F5677.S155Visit 3BaselineSubject 26177Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S156F5677.S156Visit 3BaselineSubject 26178Plaque 1ABaseline.A.Plaque 1Baseline A P1
F5677.S257F5677.S257Visit 3BaselineSubject 26001Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S258F5677.S258Visit 3BaselineSubject 26002Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S263F5677.S263Visit 3BaselineSubject 26007Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S264F5677.S264Visit 3BaselineSubject 26008Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S266F5677.S266Visit 3BaselineSubject 26010Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S267F5677.S267Visit 3BaselineSubject 26011Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S269F5677.S269Visit 3BaselineSubject 26013Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S270F5677.S270Visit 3BaselineSubject 26014Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S271F5677.S271Visit 3BaselineSubject 26015Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S272F5677.S272Visit 3BaselineSubject 26016Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S273F5677.S273Visit 3BaselineSubject 26017Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S274F5677.S274Visit 3BaselineSubject 26018Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S275F5677.S275Visit 3BaselineSubject 26019Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S276F5677.S276Visit 3BaselineSubject 26020Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S278F5677.S278Visit 3BaselineSubject 26022Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S279F5677.S279Visit 3BaselineSubject 26023Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S280F5677.S280Visit 3BaselineSubject 26024Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S282F5677.S282Visit 3BaselineSubject 26028Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S284F5677.S284Visit 3BaselineSubject 26030Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S287F5677.S287Visit 3BaselineSubject 26033Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S288F5677.S288Visit 3BaselineSubject 26034Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S289F5677.S289Visit 3BaselineSubject 26035Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S290F5677.S290Visit 3BaselineSubject 26036Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S291F5677.S291Visit 3BaselineSubject 26037Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S292F5677.S292Visit 3BaselineSubject 26038Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S293F5677.S293Visit 3BaselineSubject 26039Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S294F5677.S294Visit 3BaselineSubject 26040Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S295F5677.S295Visit 3BaselineSubject 26042Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S296F5677.S296Visit 3BaselineSubject 26043Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S297F5677.S297Visit 3BaselineSubject 26044Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S298F5677.S298Visit 3BaselineSubject 26045Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S301F5677.S301Visit 3BaselineSubject 26048Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S305F5677.S305Visit 3BaselineSubject 26055Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S306F5677.S306Visit 3BaselineSubject 26056Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S309F5677.S309Visit 3BaselineSubject 26059Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S310F5677.S310Visit 3BaselineSubject 26061Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S311F5677.S311Visit 3BaselineSubject 26062Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S312F5677.S312Visit 3BaselineSubject 26063Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S313F5677.S313Visit 3BaselineSubject 26064Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S316F5677.S316Visit 3BaselineSubject 26067Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S317F5677.S317Visit 3BaselineSubject 26068Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S318F5677.S318Visit 3BaselineSubject 26070Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S319F5677.S319Visit 3BaselineSubject 26071Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S322F5677.S322Visit 3BaselineSubject 26075Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S324F5677.S324Visit 3BaselineSubject 26077Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S329F5677.S329Visit 3BaselineSubject 26082Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S332F5677.S332Visit 3BaselineSubject 26085Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S334F5677.S334Visit 3BaselineSubject 26087Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S335F5677.S335Visit 3BaselineSubject 26088Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S339F5677.S339Visit 3BaselineSubject 26092Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S340F5677.S340Visit 3BaselineSubject 26093Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S341F5677.S341Visit 3BaselineSubject 26094Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S342F5677.S342Visit 3BaselineSubject 26095Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S343F5677.S343Visit 3BaselineSubject 26096Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S344F5677.S344Visit 3BaselineSubject 26097Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S345F5677.S345Visit 3BaselineSubject 26098Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S346F5677.S346Visit 3BaselineSubject 26099Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S351F5677.S351Visit 3BaselineSubject 26104Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S352F5677.S352Visit 3BaselineSubject 26105Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S353F5677.S353Visit 3BaselineSubject 26106Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S354F5677.S354Visit 3BaselineSubject 26108Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S358F5677.S358Visit 3BaselineSubject 26113Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S359F5677.S359Visit 3BaselineSubject 26114Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S360F5677.S360Visit 3BaselineSubject 26115Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S361F5677.S361Visit 3BaselineSubject 26116Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S363F5677.S363Visit 3BaselineSubject 26119Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S366F5677.S366Visit 3BaselineSubject 26122Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S369F5677.S369Visit 3BaselineSubject 26125Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S370F5677.S370Visit 3BaselineSubject 26126Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S371F5677.S371Visit 3BaselineSubject 26127Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S373F5677.S373Visit 3BaselineSubject 26131Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S375F5677.S375Visit 3BaselineSubject 26134Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S376F5677.S376Visit 3BaselineSubject 26135Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S377F5677.S377Visit 3BaselineSubject 26136Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S378F5677.S378Visit 3BaselineSubject 26140Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S379F5677.S379Visit 3BaselineSubject 26141Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S380F5677.S380Visit 3BaselineSubject 26142Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S383F5677.S383Visit 3BaselineSubject 26145Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S385F5677.S385Visit 3BaselineSubject 26147Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S393F5677.S393Visit 3BaselineSubject 26157Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S394F5677.S394Visit 3BaselineSubject 26158Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S395F5677.S395Visit 3BaselineSubject 26159Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S396F5677.S396Visit 3BaselineSubject 26160Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S397F5677.S397Visit 3BaselineSubject 26161Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S398F5677.S398Visit 3BaselineSubject 26162Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S399F5677.S399Visit 3BaselineSubject 26163Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S401F5677.S401Visit 3BaselineSubject 26165Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S402F5677.S402Visit 3BaselineSubject 26166Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S403F5677.S403Visit 3BaselineSubject 26167Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S407F5677.S407Visit 3BaselineSubject 26173Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S411F5677.S411Visit 3BaselineSubject 26177Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S412F5677.S412Visit 3BaselineSubject 26178Plaque 2ABaseline.A.Plaque 2Baseline A P2
F5677.S003F5677.S003Visit 3BaselineSubject 26003Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S004F5677.S004Visit 3BaselineSubject 26004Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S005F5677.S005Visit 3BaselineSubject 26005Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S006F5677.S006Visit 3BaselineSubject 26006Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S009F5677.S009Visit 3BaselineSubject 26009Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S012F5677.S012Visit 3BaselineSubject 26012Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S021F5677.S021Visit 3BaselineSubject 26021Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S025F5677.S025Visit 3BaselineSubject 26027Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S027F5677.S027Visit 3BaselineSubject 26029Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S029F5677.S029Visit 3BaselineSubject 26031Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S030F5677.S030Visit 3BaselineSubject 26032Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S043F5677.S043Visit 3BaselineSubject 26046Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S044F5677.S044Visit 3BaselineSubject 26047Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S046F5677.S046Visit 3BaselineSubject 26050Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S047F5677.S047Visit 3BaselineSubject 26052Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S048F5677.S048Visit 3BaselineSubject 26054Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S051F5677.S051Visit 3BaselineSubject 26057Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S052F5677.S052Visit 3BaselineSubject 26058Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S058F5677.S058Visit 3BaselineSubject 26065Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S059F5677.S059Visit 3BaselineSubject 26066Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S064F5677.S064Visit 3BaselineSubject 26072Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S065F5677.S065Visit 3BaselineSubject 26073Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S067F5677.S067Visit 3BaselineSubject 26076Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S070F5677.S070Visit 3BaselineSubject 26079Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S071F5677.S071Visit 3BaselineSubject 26080Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S072F5677.S072Visit 3BaselineSubject 26081Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S074F5677.S074Visit 3BaselineSubject 26083Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S075F5677.S075Visit 3BaselineSubject 26084Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S077F5677.S077Visit 3BaselineSubject 26086Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S080F5677.S080Visit 3BaselineSubject 26089Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S081F5677.S081Visit 3BaselineSubject 26090Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S082F5677.S082Visit 3BaselineSubject 26091Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S091F5677.S091Visit 3BaselineSubject 26100Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S092F5677.S092Visit 3BaselineSubject 26101Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S093F5677.S093Visit 3BaselineSubject 26102Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S094F5677.S094Visit 3BaselineSubject 26103Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S099F5677.S099Visit 3BaselineSubject 26109Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S100F5677.S100Visit 3BaselineSubject 26110Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S101F5677.S101Visit 3BaselineSubject 26111Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S106F5677.S106Visit 3BaselineSubject 26118Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S108F5677.S108Visit 3BaselineSubject 26120Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S109F5677.S109Visit 3BaselineSubject 26121Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S111F5677.S111Visit 3BaselineSubject 26123Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S112F5677.S112Visit 3BaselineSubject 26124Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S116F5677.S116Visit 3BaselineSubject 26129Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S118F5677.S118Visit 3BaselineSubject 26132Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S125F5677.S125Visit 3BaselineSubject 26143Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S126F5677.S126Visit 3BaselineSubject 26144Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S128F5677.S128Visit 3BaselineSubject 26146Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S130F5677.S130Visit 3BaselineSubject 26148Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S131F5677.S131Visit 3BaselineSubject 26149Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S132F5677.S132Visit 3BaselineSubject 26151Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S133F5677.S133Visit 3BaselineSubject 26152Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S134F5677.S134Visit 3BaselineSubject 26154Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S135F5677.S135Visit 3BaselineSubject 26155Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S136F5677.S136Visit 3BaselineSubject 26156Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S144F5677.S144Visit 3BaselineSubject 26164Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S148F5677.S148Visit 3BaselineSubject 26168Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S149F5677.S149Visit 3BaselineSubject 26170Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S150F5677.S150Visit 3BaselineSubject 26171Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S152F5677.S152Visit 3BaselineSubject 26174Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S153F5677.S153Visit 3BaselineSubject 26175Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S154F5677.S154Visit 3BaselineSubject 26176Plaque 1BBaseline.B.Plaque 1Baseline B P1
F5677.S259F5677.S259Visit 3BaselineSubject 26003Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S260F5677.S260Visit 3BaselineSubject 26004Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S261F5677.S261Visit 3BaselineSubject 26005Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S262F5677.S262Visit 3BaselineSubject 26006Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S265F5677.S265Visit 3BaselineSubject 26009Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S268F5677.S268Visit 3BaselineSubject 26012Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S277F5677.S277Visit 3BaselineSubject 26021Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S281F5677.S281Visit 3BaselineSubject 26027Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S283F5677.S283Visit 3BaselineSubject 26029Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S285F5677.S285Visit 3BaselineSubject 26031Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S286F5677.S286Visit 3BaselineSubject 26032Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S299F5677.S299Visit 3BaselineSubject 26046Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S300F5677.S300Visit 3BaselineSubject 26047Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S302F5677.S302Visit 3BaselineSubject 26050Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S303F5677.S303Visit 3BaselineSubject 26052Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S304F5677.S304Visit 3BaselineSubject 26054Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S307F5677.S307Visit 3BaselineSubject 26057Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S308F5677.S308Visit 3BaselineSubject 26058Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S314F5677.S314Visit 3BaselineSubject 26065Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S315F5677.S315Visit 3BaselineSubject 26066Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S320F5677.S320Visit 3BaselineSubject 26072Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S321F5677.S321Visit 3BaselineSubject 26073Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S323F5677.S323Visit 3BaselineSubject 26076Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S326F5677.S326Visit 3BaselineSubject 26079Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S327F5677.S327Visit 3BaselineSubject 26080Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S328F5677.S328Visit 3BaselineSubject 26081Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S330F5677.S330Visit 3BaselineSubject 26083Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S331F5677.S331Visit 3BaselineSubject 26084Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S333F5677.S333Visit 3BaselineSubject 26086Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S336F5677.S336Visit 3BaselineSubject 26089Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S337F5677.S337Visit 3BaselineSubject 26090Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S338F5677.S338Visit 3BaselineSubject 26091Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S347F5677.S347Visit 3BaselineSubject 26100Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S348F5677.S348Visit 3BaselineSubject 26101Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S349F5677.S349Visit 3BaselineSubject 26102Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S350F5677.S350Visit 3BaselineSubject 26103Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S355F5677.S355Visit 3BaselineSubject 26109Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S356F5677.S356Visit 3BaselineSubject 26110Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S357F5677.S357Visit 3BaselineSubject 26111Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S362F5677.S362Visit 3BaselineSubject 26118Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S364F5677.S364Visit 3BaselineSubject 26120Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S365F5677.S365Visit 3BaselineSubject 26121Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S367F5677.S367Visit 3BaselineSubject 26123Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S368F5677.S368Visit 3BaselineSubject 26124Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S372F5677.S372Visit 3BaselineSubject 26129Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S374F5677.S374Visit 3BaselineSubject 26132Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S381F5677.S381Visit 3BaselineSubject 26143Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S382F5677.S382Visit 3BaselineSubject 26144Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S384F5677.S384Visit 3BaselineSubject 26146Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S386F5677.S386Visit 3BaselineSubject 26148Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S387F5677.S387Visit 3BaselineSubject 26149Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S388F5677.S388Visit 3BaselineSubject 26151Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S389F5677.S389Visit 3BaselineSubject 26152Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S390F5677.S390Visit 3BaselineSubject 26154Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S391F5677.S391Visit 3BaselineSubject 26155Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S392F5677.S392Visit 3BaselineSubject 26156Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S400F5677.S400Visit 3BaselineSubject 26164Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S404F5677.S404Visit 3BaselineSubject 26168Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S405F5677.S405Visit 3BaselineSubject 26170Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S406F5677.S406Visit 3BaselineSubject 26171Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S408F5677.S408Visit 3BaselineSubject 26174Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S409F5677.S409Visit 3BaselineSubject 26175Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S410F5677.S410Visit 3BaselineSubject 26176Plaque 2BBaseline.B.Plaque 2Baseline B P2
F5677.S069F5677.S069Visit 3BaselineSubject 26078Plaque 1NABaseline.NA.Plaque 1Baseline NA P1
F5677.S325F5677.S325Visit 3BaselineSubject 26078Plaque 2NABaseline.NA.Plaque 2Baseline NA P2
 
 

ASV Read Counts by Samples

#Sample IDRead Count
F5677.S0494,271
F5677.S0194,971
F5677.S0775,472
F5677.S1915,791
F5677.S1926,081
F5677.S4676,200
F5677.S4756,377
F5677.S0216,386
F5677.S0756,425
F5677.S5456,655
F5677.S0936,761
F5677.S2966,849
F5677.S1936,861
F5677.S0956,921
F5677.S5476,957
F5677.S1147,015
F5677.S0807,081
F5677.S2177,159
F5677.S2207,167
F5677.S1837,225
F5677.S5297,230
F5677.S1697,235
F5677.S0917,242
F5677.S1867,280
F5677.S0227,315
F5677.S2217,395
F5677.S0177,422
F5677.S1877,447
F5677.S5467,454
F5677.S2247,478
F5677.S2087,506
F5677.S2277,526
F5677.S0187,539
F5677.S1897,553
F5677.S0567,587
F5677.S6007,601
F5677.S1857,611
F5677.S2057,678
F5677.S1517,683
F5677.S0737,692
F5677.S5957,695
F5677.S1117,735
F5677.S1847,778
F5677.S0057,782
F5677.S1497,814
F5677.S0357,825
F5677.S2227,867
F5677.S5347,889
F5677.S1437,922
F5677.S6517,980
F5677.S1997,982
F5677.S6478,001
F5677.S5638,002
F5677.S0908,046
F5677.S0138,050
F5677.S6738,063
F5677.S1188,131
F5677.S6088,131
F5677.S0288,154
F5677.S6418,172
F5677.S1608,192
F5677.S2258,218
F5677.S1488,243
F5677.S0798,258
F5677.S1968,265
F5677.S1978,298
F5677.S2308,345
F5677.S1908,354
F5677.S5068,355
F5677.S1718,452
F5677.S1138,463
F5677.S6698,489
F5677.S0528,506
F5677.S5998,506
F5677.S0268,522
F5677.S0128,558
F5677.S6428,574
F5677.S1198,579
F5677.S1948,589
F5677.S1368,603
F5677.S6228,611
F5677.S2138,612
F5677.S6588,613
F5677.S0298,615
F5677.S1408,615
F5677.S0098,648
F5677.S1258,655
F5677.S2098,680
F5677.S2238,680
F5677.S5038,709
F5677.S6018,740
F5677.S1128,789
F5677.S5078,796
F5677.S0948,828
F5677.S1458,831
F5677.S2128,861
F5677.S1058,877
F5677.S0558,885
F5677.S0118,889
F5677.S1708,907
F5677.S0338,920
F5677.S6438,949
F5677.S0238,961
F5677.S0318,966
F5677.S4978,975
F5677.S0638,995
F5677.S0379,018
F5677.S4839,025
F5677.S6759,028
F5677.S0249,052
F5677.S6049,078
F5677.S1249,145
F5677.S2199,149
F5677.S0259,181
F5677.S2169,181
F5677.S0549,183
F5677.S1599,190
F5677.S5979,214
F5677.S3469,214
F5677.S1559,232
F5677.S1079,256
F5677.S5309,261
F5677.S6709,281
F5677.S0609,290
F5677.S5319,300
F5677.S6569,302
F5677.S0459,313
F5677.S0599,338
F5677.S1479,354
F5677.S2029,355
F5677.S0279,361
F5677.S4789,366
F5677.S1329,374
F5677.S1399,416
F5677.S6719,434
F5677.S5859,456
F5677.S5719,472
F5677.S5339,501
F5677.S5699,534
F5677.S6359,548
F5677.S1039,578
F5677.S4189,614
F5677.S1689,631
F5677.S6219,636
F5677.S3189,642
F5677.S0749,645
F5677.S3199,679
F5677.S2159,688
F5677.S1269,750
F5677.S0859,769
F5677.S1359,773
F5677.S0509,782
F5677.S6809,790
F5677.S0929,814
F5677.S0409,830
F5677.S1529,833
F5677.S0439,835
F5677.S1219,848
F5677.S1309,852
F5677.S6579,861
F5677.S1009,865
F5677.S2449,879
F5677.S5059,904
F5677.S0489,914
F5677.S1449,928
F5677.S2019,931
F5677.S4819,934
F5677.S6039,941
F5677.S6789,952
F5677.S0519,954
F5677.S5849,960
F5677.S56610,029
F5677.S55510,040
F5677.S56810,043
F5677.S09710,061
F5677.S07610,075
F5677.S65510,103
F5677.S56710,168
F5677.S03610,192
F5677.S20010,217
F5677.S08310,218
F5677.S05810,228
F5677.S39810,259
F5677.S10810,282
F5677.S47210,287
F5677.S54110,313
F5677.S01510,315
F5677.S06910,321
F5677.S17210,325
F5677.S59610,351
F5677.S07210,354
F5677.S50810,365
F5677.S64510,370
F5677.S47610,370
F5677.S39510,391
F5677.S11710,397
F5677.S41510,432
F5677.S17710,434
F5677.S12010,455
F5677.S15310,458
F5677.S20310,464
F5677.S41110,490
F5677.S62510,501
F5677.S48210,503
F5677.S17310,529
F5677.S51210,529
F5677.S11510,545
F5677.S05310,547
F5677.S51010,561
F5677.S66710,563
F5677.S66810,583
F5677.S66510,608
F5677.S41410,624
F5677.S37510,629
F5677.S59310,634
F5677.S43810,661
F5677.S66210,662
F5677.S21410,672
F5677.S66310,706
F5677.S14610,714
F5677.S67610,731
F5677.S23710,750
F5677.S00410,754
F5677.S16710,775
F5677.S64610,786
F5677.S35110,797
F5677.S59810,803
F5677.S03410,812
F5677.S06610,831
F5677.S63810,841
F5677.S20610,869
F5677.S49910,878
F5677.S54310,886
F5677.S39410,893
F5677.S19510,906
F5677.S54410,910
F5677.S47410,922
F5677.S13310,947
F5677.S66610,960
F5677.S63210,969
F5677.S21810,977
F5677.S49110,992
F5677.S49811,006
F5677.S10611,019
F5677.S01411,043
F5677.S20411,075
F5677.S55711,089
F5677.S06711,096
F5677.S52711,103
F5677.S44211,105
F5677.S63711,115
F5677.S03211,122
F5677.S47711,124
F5677.S65311,146
F5677.S61111,188
F5677.S32011,196
F5677.S62311,218
F5677.S61911,254
F5677.S36311,262
F5677.S01611,266
F5677.S00711,266
F5677.S01011,280
F5677.S16411,289
F5677.S14211,305
F5677.S51111,329
F5677.S25111,373
F5677.S08111,435
F5677.S22611,458
F5677.S08911,474
F5677.S09811,484
F5677.S13411,511
F5677.S09911,514
F5677.S30711,531
F5677.S54011,561
F5677.S53211,576
F5677.S15711,579
F5677.S18811,591
F5677.S36711,594
F5677.S07011,650
F5677.S56011,662
F5677.S27511,667
F5677.S50011,686
F5677.S48611,689
F5677.S63911,720
F5677.S12911,730
F5677.S53711,737
F5677.S51511,778
F5677.S12211,800
F5677.S60711,810
F5677.S62011,824
F5677.S16611,850
F5677.S41211,865
F5677.S67911,872
F5677.S65011,876
F5677.S37211,876
F5677.S57711,903
F5677.S07811,905
F5677.S52611,913
F5677.S55611,928
F5677.S15611,945
F5677.S45811,964
F5677.S48912,005
F5677.S58812,008
F5677.S14112,013
F5677.S17812,020
F5677.S06412,020
F5677.S06512,026
F5677.S68112,052
F5677.S64012,068
F5677.S06812,081
F5677.S17512,096
F5677.S57312,106
F5677.S52012,131
F5677.S08712,148
F5677.S18012,160
F5677.S61512,172
F5677.S58312,198
F5677.S16312,212
F5677.S42812,216
F5677.S67212,220
F5677.S50912,222
F5677.S31612,222
F5677.S10912,227
F5677.S28112,250
F5677.S30412,278
F5677.S60212,310
F5677.S46312,320
F5677.S15012,332
F5677.S60612,336
F5677.S25212,337
F5677.S39012,376
F5677.S08812,383
F5677.S13712,418
F5677.S49012,431
F5677.S10412,481
F5677.S61612,528
F5677.S25812,544
F5677.S17412,576
F5677.S35512,600
F5677.S48812,622
F5677.S28012,647
F5677.S65412,663
F5677.S59412,671
F5677.S62812,683
F5677.S27912,686
F5677.S43012,694
F5677.S44812,723
F5677.S43612,724
F5677.S55812,732
F5677.S51312,734
F5677.S61212,744
F5677.S47912,745
F5677.S02012,782
F5677.S05712,784
F5677.S64412,799
F5677.S00112,853
F5677.S67712,875
F5677.S00812,880
F5677.S12712,893
F5677.S15412,921
F5677.S45012,923
F5677.S17912,929
F5677.S61412,930
F5677.S12312,932
F5677.S41312,952
F5677.S52112,953
F5677.S16512,957
F5677.S37312,978
F5677.S53912,991
F5677.S46812,995
F5677.S44913,004
F5677.S18113,017
F5677.S56513,021
F5677.S03913,035
F5677.S57513,037
F5677.S62613,055
F5677.S52313,056
F5677.S29313,060
F5677.S44013,071
F5677.S57413,140
F5677.S27113,151
F5677.S06213,155
F5677.S44413,170
F5677.S50413,176
F5677.S60513,214
F5677.S42013,237
F5677.S09613,260
F5677.S26913,265
F5677.S33013,299
F5677.S36813,308
F5677.S41013,318
F5677.S25513,336
F5677.S30613,346
F5677.S50213,358
F5677.S10113,398
F5677.S51913,429
F5677.S55213,461
F5677.S40213,478
F5677.S23913,482
F5677.S03013,489
F5677.S64813,496
F5677.S49613,522
F5677.S57813,556
F5677.S38413,557
F5677.S56413,573
F5677.S57213,575
F5677.S68213,578
F5677.S04113,579
F5677.S39613,616
F5677.S48013,620
F5677.S19813,630
F5677.S24513,632
F5677.S51813,663
F5677.S59113,667
F5677.S42613,678
F5677.S39313,716
F5677.S28813,728
F5677.S28213,776
F5677.S63013,777
F5677.S33613,782
F5677.S33913,802
F5677.S37013,802
F5677.S57013,809
F5677.S52513,830
F5677.S10213,843
F5677.S45113,846
F5677.S53813,869
F5677.S26013,882
F5677.S29513,903
F5677.S25713,908
F5677.S28513,915
F5677.S49513,920
F5677.S54913,926
F5677.S55913,932
F5677.S06113,935
F5677.S24113,960
F5677.S39913,961
F5677.S25313,966
F5677.S37414,003
F5677.S16214,026
F5677.S00214,037
F5677.S59014,040
F5677.S46114,068
F5677.S30914,089
F5677.S24214,120
F5677.S43214,165
F5677.S34314,182
F5677.S27714,192
F5677.S67414,223
F5677.S31014,238
F5677.S27214,268
F5677.S63614,280
F5677.S43914,283
F5677.S33414,290
F5677.S00614,309
F5677.S44514,324
F5677.S34814,361
F5677.S50114,372
F5677.S58114,380
F5677.S04614,391
F5677.S52414,409
F5677.S61314,423
F5677.S23814,427
F5677.S12814,431
F5677.S37614,440
F5677.S38214,465
F5677.S07114,468
F5677.S39714,477
F5677.S45214,500
F5677.S30114,522
F5677.S44314,530
F5677.S65914,531
F5677.S31714,546
F5677.S35014,566
F5677.S18214,593
F5677.S39114,614
F5677.S42214,654
F5677.S45514,673
F5677.S38714,676
F5677.S46414,678
F5677.S35314,805
F5677.S38514,812
F5677.S57614,859
F5677.S45614,909
F5677.S29914,917
F5677.S41914,923
F5677.S24714,932
F5677.S33114,934
F5677.S35614,985
F5677.S28714,989
F5677.S35214,999
F5677.S52215,000
F5677.S25915,013
F5677.S36215,047
F5677.S33715,048
F5677.S32215,064
F5677.S48715,069
F5677.S46515,078
F5677.S48515,127
F5677.S58915,163
F5677.S46615,198
F5677.S17615,199
F5677.S44715,257
F5677.S23615,272
F5677.S62715,287
F5677.S30815,291
F5677.S59215,295
F5677.S03815,300
F5677.S45315,337
F5677.S33515,343
F5677.S32815,359
F5677.S24015,411
F5677.S55315,456
F5677.S25615,507
F5677.S25015,509
F5677.S29215,526
F5677.S43415,526
F5677.S34715,540
F5677.S29415,554
F5677.S00315,593
F5677.S58615,594
F5677.S27615,600
F5677.S26515,636
F5677.S28915,668
F5677.S37915,674
F5677.S27415,682
F5677.S63315,702
F5677.S60915,711
F5677.S34515,746
F5677.S40815,751
F5677.S24615,751
F5677.S40315,781
F5677.S42415,786
F5677.S30515,789
F5677.S36415,792
F5677.S24315,823
F5677.S28415,845
F5677.S23415,975
F5677.S26115,977
F5677.S42115,994
F5677.S28616,034
F5677.S38116,056
F5677.S39216,064
F5677.S27816,095
F5677.S37716,103
F5677.S32516,115
F5677.S47316,119
F5677.S55116,140
F5677.S58716,180
F5677.S22816,199
F5677.S23216,247
F5677.S30316,256
F5677.S61816,275
F5677.S30016,286
F5677.S37816,306
F5677.S52816,309
F5677.S22916,318
F5677.S66016,325
F5677.S48416,331
F5677.S38616,358
F5677.S49316,375
F5677.S33816,497
F5677.S44616,529
F5677.S26616,532
F5677.S47116,533
F5677.S53616,536
F5677.S56216,566
F5677.S42316,569
F5677.S23316,617
F5677.S31516,636
F5677.S37116,642
F5677.S46216,648
F5677.S35416,686
F5677.S35816,729
F5677.S34116,746
F5677.S36916,820
F5677.S41616,842
F5677.S38816,897
F5677.S40516,935
F5677.S32116,949
F5677.S24916,962
F5677.S38016,988
F5677.S04216,998
F5677.S51617,014
F5677.S30217,038
F5677.S54817,076
F5677.S31217,090
F5677.S34417,092
F5677.S31417,102
F5677.S62917,154
F5677.S38917,312
F5677.S32717,469
F5677.S32317,509
F5677.S40417,513
F5677.S26817,517
F5677.S62417,535
F5677.S16117,543
F5677.S11617,601
F5677.S34017,616
F5677.S49217,686
F5677.S45417,709
F5677.S29017,801
F5677.S42917,819
F5677.S34917,837
F5677.S40917,867
F5677.S43517,896
F5677.S56117,899
F5677.S25417,911
F5677.S11017,916
F5677.S26317,939
F5677.S33217,954
F5677.S43717,973
F5677.S43118,009
F5677.S36518,029
F5677.S43318,056
F5677.S42518,106
F5677.S04718,147
F5677.S63118,155
F5677.S34218,180
F5677.S32618,186
F5677.S53518,191
F5677.S08218,196
F5677.S35718,230
F5677.S63418,278
F5677.S55018,494
F5677.S57918,532
F5677.S36618,544
F5677.S35918,609
F5677.S44118,619
F5677.S46918,684
F5677.S42718,775
F5677.S61718,795
F5677.S47018,798
F5677.S13118,820
F5677.S33318,904
F5677.S31118,910
F5677.S66418,923
F5677.S36118,991
F5677.S40719,042
F5677.S66119,051
F5677.S27019,244
F5677.S40019,447
F5677.S40119,455
F5677.S21019,631
F5677.S04419,652
F5677.S23119,654
F5677.S29719,731
F5677.S54219,794
F5677.S41719,839
F5677.S36020,004
F5677.S29120,174
F5677.S21120,247
F5677.S58220,301
F5677.S51720,334
F5677.S23520,348
F5677.S26220,350
F5677.S45720,426
F5677.S64920,438
F5677.S24820,480
F5677.S15820,586
F5677.S40620,647
F5677.S46020,906
F5677.S28321,038
F5677.S26721,120
F5677.S38321,363
F5677.S27321,409
F5677.S32421,432
F5677.S31321,930
F5677.S49422,243
F5677.S29822,529
F5677.S26423,010
F5677.S51423,137
F5677.S32923,283
F5677.S55423,731
F5677.S13823,972
F5677.S58024,163
F5677.S20724,599
F5677.S08625,122
F5677.S61025,333
F5677.S08429,612
F5677.S45932,972
F5677.S65233,034
 
 
 

VII. Analysis - Read Taxonomy Assignment

Read Taxonomy Assignment - Methods

 

The species-level, open-reference 16S rRNA NGS reads taxonomy assignment pipeline

Version 20210310
 

1. Raw sequences reads in FASTA format were BLASTN-searched against a combined set of 16S rRNA reference sequences. It consists of MOMD (version 0.1), the HOMD (version 15.2 http://www.homd.org/index.php?name=seqDownload&file&type=R ), HOMD 16S rRNA RefSeq Extended Version 1.1 (EXT), GreenGene Gold (GG) (http://greengenes.lbl.gov/Download/Sequence_Data/Fasta_data_files/gold_strains_gg16S_aligned.fasta.gz) , and the NCBI 16S rRNA reference sequence set (https://ftp.ncbi.nlm.nih.gov/blast/db/16S_ribosomal_RNA.tar.gz). These sequences were screened and combined to remove short sequences (<1000nt), chimera, duplicated and sub-sequences, as well as sequences with poor taxonomy annotation (e.g., without species information). This process resulted in 1,015 from HOMD V15.22, 495 from EXT, 3,940 from GG and 18,044 from NCBI, a total of 25,120 sequences. Altogether these sequence represent a total of 15,601 oral and non-oral microbial species.

The NCBI BLASTN version 2.7.1+ (Zhang et al, 2000) was used with the default parameters. Reads with ≥ 98% sequence identity to the matched reference and ≥ 90% alignment length (i.e., ≥ 90% of the read length that was aligned to the reference and was used to calculate the sequence percent identity) were classified based on the taxonomy of the reference sequence with highest sequence identity. If a read matched with reference sequences representing more than one species with equal percent identity and alignment length, it was subject to chimera checking with USEARCH program version v8.1.1861 (Edgar 2010). Non-chimeric reads with multi-species best hits were considered valid and were assigned with a unique species notation (e.g., spp) denoting unresolvable multiple species.

2. Unassigned reads (i.e., reads with < 98% identity or < 90% alignment length) were pooled together and reads < 200 bases were removed. The remaining reads were subject to the de novo operational taxonomy unit (OTU) calling and chimera checking using the USEARCH program version v8.1.1861 (Edgar 2010). The de novo OTU calling and chimera checking was done using 98% as the sequence identity cutoff, i.e., the species-level OTU. The output of this step produced species-level de novo clustered OTUs with 98% identity. Representative reads from each of the OTUs/species were then BLASTN-searched against the same reference sequence set again to determine the closest species for these potential novel species. These potential novel species were pooled together with the reads that were signed to specie-level in the previous step, for down-stream analyses.

Reference:
Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010 Oct 1;26(19):2460-1. doi: 10.1093/bioinformatics/btq461. Epub 2010 Aug 12. PubMed PMID: 20709691.

3. Designations used in the taxonomy:

	1) Taxonomy levels are indicated by these prefixes:
	
	   k__: domain/kingdom
	   p__: phylum
	   c__: class
	   o__: order
	   f__: family
	   g__: genus  
	   s__: species
	
	   Example: 
	
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Blautia;s__faecis
		
	2) Unique level identified – known species:
	   
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__hominis
	
	   The above example shows some reads match to a single species (all levels are unique)
	
	3) Non-unique level identified – known species:

	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__multispecies_spp123_3
	   
	   The above example “s__multispecies_spp123_3” indicates certain reads equally match to 3 species of the 
	   genus Roseburia; the “spp123” is a temporally assigned species ID.
	
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__multigenus;s__multispecies_spp234_5
	   
	   The above example indicates certain reads match equally to 5 different species, which belong to multiple genera.; 
	   the “spp234” is a temporally assigned species ID.
	
	4) Unique level identified – unknown species, potential novel species:
	   
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__ hominis_nov_97%
	   
	   The above example indicates that some reads have no match to any of the reference sequences with 
	   sequence identity ≥ 98% and percent coverage (alignment length)  ≥ 98% as well. However this groups 
	   of reads (actually the representative read from a de novo  OTU) has 96% percent identity to 
	   Roseburia hominis, thus this is a potential novel species, closest to Roseburia hominis. 
	   (But they are not the same species).
	
	5) Multiple level identified – unknown species, potential novel species:
	   k__Bacteria;p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Roseburia;s__ multispecies_sppn123_3_nov_96%
	
	   The above example indicates that some reads have no match to any of the reference sequences 
	   with sequence identity ≥ 98% and percent coverage (alignment length)  ≥ 98% as well. 
	   However this groups of reads (actually the representative read from a de novo  OTU) 
	   has 96% percent identity equally to 3 species in Roseburia. Thus this is no single 
	   closest species, instead this group of reads match equally to multiple species at 96%. 
	   Since they have passed chimera check so they represent a novel species. “sppn123” is a 
	   temporary ID for this potential novel species.

 
4. The taxonomy assignment algorithm is illustrated in this flow char below:
 
 
 
 

Read Taxonomy Assignment - Result Summary *

CodeCategoryMPC=0% (>=1 read)MPC=0.01%(>=881 reads)
ATotal reads8,851,0608,851,060
BTotal assigned reads8,810,2968,810,296
CAssigned reads in species with read count < MPC0122,874
DAssigned reads in samples with read count < 50000
ETotal samples682682
FSamples with reads >= 500682682
GSamples with reads < 50000
HTotal assigned reads used for analysis (B-C-D)8,810,2968,687,422
IReads assigned to single species8,349,6468,287,261
JReads assigned to multiple species254,402245,521
KReads assigned to novel species206,248154,640
LTotal number of species1,299416
MNumber of single species614363
NNumber of multi-species6915
ONumber of novel species61638
PTotal unassigned reads40,76440,764
QChimeric reads5,7975,797
RReads without BLASTN hits354354
SOthers: short, low quality, singletons, etc.34,61334,613
A=B+P=C+D+H+Q+R+S
E=F+G
B=C+D+H
H=I+J+K
L=M+N+O
P=Q+R+S
* MPC = Minimal percent (of all assigned reads) read count per species, species with read count < MPC were removed.
* Samples with reads < 500 were removed from downstream analyses.
* The assignment result from MPC=0.01% was used in the downstream analyses.
 
 
 

Read Taxonomy Assignment - ASV Species-Level Read Counts Table

This table shows the read counts for each sample (columns) and each species identified based on the ASV sequences. The downstream analyses were based on this table.
SPIDTaxonomyF5677.S001F5677.S002F5677.S003F5677.S004F5677.S005F5677.S006F5677.S007F5677.S008F5677.S009F5677.S010F5677.S011F5677.S012F5677.S013F5677.S014F5677.S015F5677.S016F5677.S017F5677.S018F5677.S019F5677.S020F5677.S021F5677.S022F5677.S023F5677.S024F5677.S025F5677.S026F5677.S027F5677.S028F5677.S029F5677.S030F5677.S031F5677.S032F5677.S033F5677.S034F5677.S035F5677.S036F5677.S037F5677.S038F5677.S039F5677.S040F5677.S041F5677.S042F5677.S043F5677.S044F5677.S045F5677.S046F5677.S047F5677.S048F5677.S049F5677.S050F5677.S051F5677.S052F5677.S053F5677.S054F5677.S055F5677.S056F5677.S057F5677.S058F5677.S059F5677.S060F5677.S061F5677.S062F5677.S063F5677.S064F5677.S065F5677.S066F5677.S067F5677.S068F5677.S069F5677.S070F5677.S071F5677.S072F5677.S073F5677.S074F5677.S075F5677.S076F5677.S077F5677.S078F5677.S079F5677.S080F5677.S081F5677.S082F5677.S083F5677.S084F5677.S085F5677.S086F5677.S087F5677.S088F5677.S089F5677.S090F5677.S091F5677.S092F5677.S093F5677.S094F5677.S095F5677.S096F5677.S097F5677.S098F5677.S099F5677.S100F5677.S101F5677.S102F5677.S103F5677.S104F5677.S105F5677.S106F5677.S107F5677.S108F5677.S109F5677.S110F5677.S111F5677.S112F5677.S113F5677.S114F5677.S115F5677.S116F5677.S117F5677.S118F5677.S119F5677.S120F5677.S121F5677.S122F5677.S123F5677.S124F5677.S125F5677.S126F5677.S127F5677.S128F5677.S129F5677.S130F5677.S131F5677.S132F5677.S133F5677.S134F5677.S135F5677.S136F5677.S137F5677.S138F5677.S139F5677.S140F5677.S141F5677.S142F5677.S143F5677.S144F5677.S145F5677.S146F5677.S147F5677.S148F5677.S149F5677.S150F5677.S151F5677.S152F5677.S153F5677.S154F5677.S155F5677.S156F5677.S157F5677.S158F5677.S159F5677.S160F5677.S161F5677.S162F5677.S163F5677.S164F5677.S165F5677.S166F5677.S167F5677.S168F5677.S169F5677.S170F5677.S171F5677.S172F5677.S173F5677.S174F5677.S175F5677.S176F5677.S177F5677.S178F5677.S179F5677.S180F5677.S181F5677.S182F5677.S183F5677.S184F5677.S185F5677.S186F5677.S187F5677.S188F5677.S189F5677.S190F5677.S191F5677.S192F5677.S193F5677.S194F5677.S195F5677.S196F5677.S197F5677.S198F5677.S199F5677.S200F5677.S201F5677.S202F5677.S203F5677.S204F5677.S205F5677.S206F5677.S207F5677.S208F5677.S209F5677.S210F5677.S211F5677.S212F5677.S213F5677.S214F5677.S215F5677.S216F5677.S217F5677.S218F5677.S219F5677.S220F5677.S221F5677.S222F5677.S223F5677.S224F5677.S225F5677.S226F5677.S227F5677.S228F5677.S229F5677.S230F5677.S231F5677.S232F5677.S233F5677.S234F5677.S235F5677.S236F5677.S237F5677.S238F5677.S239F5677.S240F5677.S241F5677.S242F5677.S243F5677.S244F5677.S245F5677.S246F5677.S247F5677.S248F5677.S249F5677.S250F5677.S251F5677.S252F5677.S253F5677.S254F5677.S255F5677.S256F5677.S257F5677.S258F5677.S259F5677.S260F5677.S261F5677.S262F5677.S263F5677.S264F5677.S265F5677.S266F5677.S267F5677.S268F5677.S269F5677.S270F5677.S271F5677.S272F5677.S273F5677.S274F5677.S275F5677.S276F5677.S277F5677.S278F5677.S279F5677.S280F5677.S281F5677.S282F5677.S283F5677.S284F5677.S285F5677.S286F5677.S287F5677.S288F5677.S289F5677.S290F5677.S291F5677.S292F5677.S293F5677.S294F5677.S295F5677.S296F5677.S297F5677.S298F5677.S299F5677.S300F5677.S301F5677.S302F5677.S303F5677.S304F5677.S305F5677.S306F5677.S307F5677.S308F5677.S309F5677.S310F5677.S311F5677.S312F5677.S313F5677.S314F5677.S315F5677.S316F5677.S317F5677.S318F5677.S319F5677.S320F5677.S321F5677.S322F5677.S323F5677.S324F5677.S325F5677.S326F5677.S327F5677.S328F5677.S329F5677.S330F5677.S331F5677.S332F5677.S333F5677.S334F5677.S335F5677.S336F5677.S337F5677.S338F5677.S339F5677.S340F5677.S341F5677.S342F5677.S343F5677.S344F5677.S345F5677.S346F5677.S347F5677.S348F5677.S349F5677.S350F5677.S351F5677.S352F5677.S353F5677.S354F5677.S355F5677.S356F5677.S357F5677.S358F5677.S359F5677.S360F5677.S361F5677.S362F5677.S363F5677.S364F5677.S365F5677.S366F5677.S367F5677.S368F5677.S369F5677.S370F5677.S371F5677.S372F5677.S373F5677.S374F5677.S375F5677.S376F5677.S377F5677.S378F5677.S379F5677.S380F5677.S381F5677.S382F5677.S383F5677.S384F5677.S385F5677.S386F5677.S387F5677.S388F5677.S389F5677.S390F5677.S391F5677.S392F5677.S393F5677.S394F5677.S395F5677.S396F5677.S397F5677.S398F5677.S399F5677.S400F5677.S401F5677.S402F5677.S403F5677.S404F5677.S405F5677.S406F5677.S407F5677.S408F5677.S409F5677.S410F5677.S411F5677.S412F5677.S413F5677.S414F5677.S415F5677.S416F5677.S417F5677.S418F5677.S419F5677.S420F5677.S421F5677.S422F5677.S423F5677.S424F5677.S425F5677.S426F5677.S427F5677.S428F5677.S429F5677.S430F5677.S431F5677.S432F5677.S433F5677.S434F5677.S435F5677.S436F5677.S437F5677.S438F5677.S439F5677.S440F5677.S441F5677.S442F5677.S443F5677.S444F5677.S445F5677.S446F5677.S447F5677.S448F5677.S449F5677.S450F5677.S451F5677.S452F5677.S453F5677.S454F5677.S455F5677.S456F5677.S457F5677.S458F5677.S459F5677.S460F5677.S461F5677.S462F5677.S463F5677.S464F5677.S465F5677.S466F5677.S467F5677.S468F5677.S469F5677.S470F5677.S471F5677.S472F5677.S473F5677.S474F5677.S475F5677.S476F5677.S477F5677.S478F5677.S479F5677.S480F5677.S481F5677.S482F5677.S483F5677.S484F5677.S485F5677.S486F5677.S487F5677.S488F5677.S489F5677.S490F5677.S491F5677.S492F5677.S493F5677.S494F5677.S495F5677.S496F5677.S497F5677.S498F5677.S499F5677.S500F5677.S501F5677.S502F5677.S503F5677.S504F5677.S505F5677.S506F5677.S507F5677.S508F5677.S509F5677.S510F5677.S511F5677.S512F5677.S513F5677.S514F5677.S515F5677.S516F5677.S517F5677.S518F5677.S519F5677.S520F5677.S521F5677.S522F5677.S523F5677.S524F5677.S525F5677.S526F5677.S527F5677.S528F5677.S529F5677.S530F5677.S531F5677.S532F5677.S533F5677.S534F5677.S535F5677.S536F5677.S537F5677.S538F5677.S539F5677.S540F5677.S541F5677.S542F5677.S543F5677.S544F5677.S545F5677.S546F5677.S547F5677.S548F5677.S549F5677.S550F5677.S551F5677.S552F5677.S553F5677.S554F5677.S555F5677.S556F5677.S557F5677.S558F5677.S559F5677.S560F5677.S561F5677.S562F5677.S563F5677.S564F5677.S565F5677.S566F5677.S567F5677.S568F5677.S569F5677.S570F5677.S571F5677.S572F5677.S573F5677.S574F5677.S575F5677.S576F5677.S577F5677.S578F5677.S579F5677.S580F5677.S581F5677.S582F5677.S583F5677.S584F5677.S585F5677.S586F5677.S587F5677.S588F5677.S589F5677.S590F5677.S591F5677.S592F5677.S593F5677.S594F5677.S595F5677.S596F5677.S597F5677.S598F5677.S599F5677.S600F5677.S601F5677.S602F5677.S603F5677.S604F5677.S605F5677.S606F5677.S607F5677.S608F5677.S609F5677.S610F5677.S611F5677.S612F5677.S613F5677.S614F5677.S615F5677.S616F5677.S617F5677.S618F5677.S619F5677.S620F5677.S621F5677.S622F5677.S623F5677.S624F5677.S625F5677.S626F5677.S627F5677.S628F5677.S629F5677.S630F5677.S631F5677.S632F5677.S633F5677.S634F5677.S635F5677.S636F5677.S637F5677.S638F5677.S639F5677.S640F5677.S641F5677.S642F5677.S643F5677.S644F5677.S645F5677.S646F5677.S647F5677.S648F5677.S649F5677.S650F5677.S651F5677.S652F5677.S653F5677.S654F5677.S655F5677.S656F5677.S657F5677.S658F5677.S659F5677.S660F5677.S661F5677.S662F5677.S663F5677.S664F5677.S665F5677.S666F5677.S667F5677.S668F5677.S669F5677.S670F5677.S671F5677.S672F5677.S673F5677.S674F5677.S675F5677.S676F5677.S677F5677.S678F5677.S679F5677.S680F5677.S681F5677.S682
SP1Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Slackia;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
SP10Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;catoniae000000000000000000132000147375700000260017700000000000000000001900006300013100001550000000000000000000420000000000000000000000006600000000081027000000000143200000000000000006800000000000000005600950000888842830000000053000000000000000000000000000000000000000001142760208000000074000007410700000524000200000113000000023704100000000000000023112200032700026000004400000000500000000000000000000000006100074000001950055047600067000000000000000000000618407201610000016155680005000000000001080000000000000000173000000092000001316000000015600000000000000000000001920000000840000000000367000840000114000006600000633306700000000000132013400004500000000890156000000000000000000000000000002000124166600000082000010000001022650000055000003101400000150950007100060000000000000000000008800000018000020040000000000000013000000
SP100Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;mutans4413139900017003590031000000587000000000000000001998123100141400002600000150017000022550000343720004108703000051868699084200003400000078001723000000011408510000031510110027115332400157372037000003550272000784000054001530018160000299327080760000000033150000000011750219270000000400528500000720013850039455101017480001637023073509000855160000013200000007100239605436021421017000000000000173300418000048800000583360000573233200665200000073900024260205145900219000037960003934420041900029700000002015560007940000185577000004344330001540032843915627800034200000000031040000029309890673262015034070001203017501890015500000900000000000048100338300000111070630104700000000000000000000017300000011034000105003643000000000051700129803253347134390076322800001765000001411430045672413420016200156000000000023400698000000000001745180236498500000053020189004000009136363000330726005506323631960448000014572024991927002630001135322090014701167026612198116900198000010300028500446024037411300029269550394500124000557000021700210021196100000121900120163715726427023315700505681418933971000052401462711379001740183700313000000000000000311800390000
SP101Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Tannerellaceae;Tannerella;forsythia00000000013701311230000000042011110111400000560009431002100370010600000000059000000000001400750620000000000000000000000012801001630000000869003400330000000124000090000000114000210000089000520000000000000000490000000000006800000000000044000147021000240000000001190000000000062000000780000000438546000000430379000437161000000000000000146162107000000000097000000190002041800101056000107000123006700107248089000864400015800000000028910005111590000000190000000243276400000212140420021000013100000088080075017478000030500198122000140067001350000000126000010200164000003842960024001030000000004881040018800000470030071000013000690000000003900095061000000099406101130001666000000000580084000450000000104084000016500000003200012902801730000020600006569000044000000007500029000292455066000801840000000032852400420016000075004600000017310170134567000009003500001667100079833614415500000000857201240086157000650133000
SP102Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_subsp._vincentii0000001120000000000000000000000000210000000000052004100000000000000000000000000000000000000460000000000000000000000000000063000000000038095000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000087084000130000000000000000000000011800000000000000000000000000000000000085000000000000000000000000000000000000000000000000000270000000000004170000000000000000000000000081000000000000000000000000000000000000011200000000000000005012520000000000000005100000001690000010000000200000022012600000000000200000000005400000000075470000000000421000000000000000000000810000050000000000000390000000000000000000000000000000083800000000002900022100000000000000000000000000000018000
SP103Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Bacteroidaceae;Phocaeicola;abscessus000000000000000013000530000000000150000000390000400000000000001600000004950000000640000000000000000000000046006400000000000000000000000000000000000000000000000000000001600000007400000000000000000000000000000000000000000000000000000000010000000000000000000270000000000000000000000000000500000000000000000068000000000133000000000000000000000000530065000766600000000098246000000000000000000083051000000000000000000000000016800000000271069006502600000000000022600000000000000000042001400000000001700000000600000000000000000000000000000000000000000000000000013800000580000000000000000000003600009900071004243000000000000000000000000019000000046091000000228000000700000000000000001000000000000000000000024000000000075520268000000000000004400000000085
SP104Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oralis3000001410000005500000000240000000000005100010600000000000420000183000000000092007300013943010700000000000000570000000950034000002700000000008200000000000000060000000000000004900000002500360752061390000000000006000000000000000000085355101340000000000000000000040000001000000000000000153001650000001250000012300000000000188000000005000000000001530000006201480000000188000254000000001263000750001712190000000001390000000000000000028101941940787700000000000383062830000000000017400000000000010100242000000000000025100001970000000000000001610000000000001701300082001039367000015000000000000000610000001060004300047000000950018480660097000950251198600000039000000600000000080084144182200000000000000001230000000000000000381996003400000000001701570460000000000000111000063002015200000000000001600000000661437501305200000005707003901857000000000
SP105Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Stomatobaculum;longum000000104001156700030001150000000000007700003400000000000430000000000000087107146327400730000000000000000006000007838800000012414101370000000107290094163000039001160079000019900001500171600000730000000000000280624800023016700000012456000001280161000000010611311100015407600000023400059000001460000000001700000606017519800015503520024500014700000000021308802440000001160000000000178309213000000000000241000215000029614900002670000188048173000001000033300560170000000000445446002710040600002360000000186012800111000000000217134063800215003159700000020000000226328000000000000151000002400015300129217000193000107057000020700003240000000000000691270000000001253500124019761000001010978486006108401650011400000000190000057000490000000000000000081000000034012306300000580000000000610003200800006700000064000000006300000000096000000107000000003500001090043054012000000000000004500200000000006800096000003043000001150510000
SP107Bacteria;Firmicutes;Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;adiacens02703670000099000001510138000010114805070140016921336126023700075000002096816800000192122017514102182350151000084339500502040000210762330024900000000000870012900010300018417745000000000308860015200470154442630000296007725205401480029085132000822336416700557061000696014501475800330215139026101101582250000003200000273187000009314701660000023319700000000950000000322000128384833752062685200001152060028598000000000337004472332619778171128014103480032801970003264021036501431305622100000000000003791370121001510049103690000703673451080000313000000001833240243001490000001860221010500349000000000000000000052700000087910014100001820028200000313792340224000122940000167072041000195002260007600000098000000000028615302481200000190000012200170141008019736057920000000000267715039287960312000295000000110230310000000780650020044022201907748000000020706600000000000020305896001220000000540000780022400741709767000077026500885000000003608300001610181105174015647712001691170000111000102851580830000013500000000006605700170000115210692422558832500001515600071007213400026
SP108Bacteria;Firmicutes;Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;paradiacens002592700071000000583300000005501400121139000000051005406100000000197000169000004400168162001982000000000459205112921600000007511900000000083009306595002260000012824000991790001309400009000200006148013600143000001801310000000007000125000044300560007408400007902170000730640000000000060000000000059080119000000149094017114200000000000016400000001670273005020000022800075000114231000000194019700010700000001060142000011000001120015102600316000139000007301160000002700002371660000016400002510001046636648100000142000001450000189034800017700438000095213890190002250000001390013900006700000019900201001200115680002053570000000000000000000132134000020300000079057068000400000000000001030126810067660801390010700122000101830001080033000000000007600001313246000000000000091000008807801000013100012605850157000940761000011071620000011612901430000000062001530000000361120108204714005100000610000055000000037920000220106000005300000600004899630136000002913400850001120000
SP109Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._Oral_Taxon_17172208000430000000000000484000980110000000000202882004500032500000002260000210000005530228000002090000000001881760000000000000023300000000000225020807300009200000005130000115006300000002889800096000001180001510158648000000000709216000138000000031000002600000921700143000000000000000000007405501750161198000000000000000108000250670032000000000000000000000000000001060000000027614800011800000110000000000000000000000000000000000000000000000000000000000000000000046900000000000000000000007500006700224000000000000000270000000000000000000000000000000000720000000000010200000000000507000818073019206230000043101170001060000000774003701370003700015518660000001280122350000000003200000000000130905900021200029500000004750016544147169088000608000000390000041000000025600000034000000000000000000000150038200290000000000000194000000002640084000592000001790000044801870141000
SP11Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIVa];Lachnospiraceae_[G];sp._Oral_Taxon_B3200000000000001110000000000108000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146000000000000240000000000000000590000000000000000000021000000000000000020000000000000000000000000000000000000031000533116190000000004430000000000104016300000000000000000000000000000078000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005100000000000000000000000000000000002770000000000000000000000000000000000000000000000000000000000000000002400001160010800000000000000000000000000000000000000000340000000000000000000000000000000013000000000930000000000072000007900000000000000000000000000000000000000001080000000000000000000000000135005600000000
SP110Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-2];Saccharibacteria_(TM7)_[G-5];bacterium HMT35669487400087700170127042827200012601261332435240000048100096313358400202138001010140053011300000176381413021728424404100080710830010400021332600011800000001247011860024810420005410318790940007600340107004000065672497000000001510240018500042330052670250000086224001830197084000011312934002590886000005820263420039003400123003307650000010618804370000000007188630002130000114501040620377000000000322000020410100052251000008250329000076417411143180593480000006600154000670000016150112600680007230135908905000011300011740184650466820068044315002670052321612000000720025276025300000010275000011640902700064101220017103653540000162569176006130000004601134011970000725082204064090251000580381062101600000676107901710084501094019129000235303950027926801622200019231900027800638200002430130515900000000945700571480751366601170000039006631618704420428033100345553200003937801000070431335204002330000350360000000012200126021100019800270338016400000009752989604900030501090000346000389000015912393920651065004400042052221991014200608500105140012910000000000038400031000000000022500051000230022002061750000000137041719108606610159023901390225160
SP111Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;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
SP113Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonella;sp. HMT7800000000000000330000000636000000000008600000000000000003700000000000000000000000000000000000000000000000001530000005900000000000000000000000000000000000000000000000000000000930000000000000000000000000500000000000000000000000000000002100000000000000000000000000000000000000000000000000000001400000000000078000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012100000000000000004500000000000000014900000000000008500000000008400000000000000000000000000000000000000000000000000000000000005200000000000089000000000000000000000000000000001100000000000000000000000000000000000000000042000000000000000000000262000000000000000000000000000000000000000007000000000019000000005200
SP114Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-1];[Eubacterium]_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
SP115Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT896000000000000000000107000000000000000000007700000000000000000153021100000621140067083153000000000005400000000000000003110000000000000000122000018300000245000110000001850001280000000000370000000131000000000000000000000000000002330000000000000000000000000000000000000000000297000000436000000000000001760000000000000001830000000000000023600000000270116000000000000198000000003190000000000000000000000000000000000102000000000000000024900000000000156000000007200000000000000000241000000000000000000000000000000000050200000000000000000000000000000000000000000000000000000000000013300011491000138000000000000000000000000008800000000370000520000000000000000000018200000031000000000015100000000000000000000000000000000001020000000000108000000000000000000000113000000000000000
SP116Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Veillonella;atypica000014828000000860000000670000000000000000000820000000000000000000000000000000000000540000001170000000000000000015815400071028000010400000002300000000000000081093690000680016100001040000325000000000010000000000000070000000000470000000000000000001430021300010400001921210013000000000000920000000000000000000000000000000000000000000000000000460473000000000000000000000003200000000000006712400000000000039300002250001900063000001620124000000000001400000000091279013500355017802020000000373003160000000000000000223000000000000000000000000000000000000000000000630670132000000000000000000390000001100000000000013437400000000000000000000001680000077008501060000000000001000000038001060000000000000000420001634000115000144000000000200000000182000000400004506400000000000038000000000000000000000000000000234000000
SP117Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;haemolyticus0000000000000000000009200000000000121000000000100000000000000000000000000000000000000000000000003100000001220000000000000000000000000340000000001120000000000000000000000000000000000121000001801600000000000000000000000000000000290001620005900000000000000000000000000000000000000000000000000000000156000000000001576600000000000000000000000000000000000000001060000000000000000000000000000680000000000009300000000000000000000000000000000000000000000001160000002380000415063000000001640000000017200000000410000006100014033007000000000000004600000000000000003100000000000000000000000000000000002335000000000000000000010000001632760000000000000005700000105003201100000000000000000000165019300000000240000000000000003100000001700000000230000000000000000009100
SP118Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Catonella;morbi0000000016500310054600000000490033570041018916000038005200000470000018900000008500052660000000029048310000076000000000000580128200620000145500000000000023220012000015500001060470000000012400000450000000000011500166000048781236288620160043042000000740032000000000049000000000000055000036000000003321943700000113200870000000000369850000000000003706706126118993801270302000000420000022016500000014503000036000000001120501610000087000012000000000011116400227900000000000021400840152057000020633700000000001070002075104617201630021276000072009600000001258400000000008600002630123012300153000270007500000000000000027089107010002700000044002603101013800204000001450023003414200021900148530760480840007212300005745426225000147008004768554200000000065001900130000650000024000000000483949000450230000061024029121733800241180532900006455750720042630000000015440000009300000000300000028709618900000000002011130000000095700601149000210000082120
SP119Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT27500000000000000000082000000000032000480000000000000000000000000007000000008600000000000000001110000000000000000000038000000000000000269100000000003500000000000000000035000000000000000003600000000000000000000000000000000000000000000000000000000005923200000000000000000000043450000000000010100001670185000000000077000192000000000000014600000000000000000000043000000000000000013100000000000000000000420000000000000000153000000000049370000000000000000054000000091000000000000680000000000000000000000000000000000000000000000270000000706700000000000000870000000000000050000002700000740000000000000000000210000000000000000000000000226000750000004400000000000000014000000000002108100000000000000000000000000000000000000000001239900470000000000000000
SP12Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oris34168250007716817656151095816007600012110415200000130006800391700267199441800011527515521601550392850000013252010301060085790001740014924412300842230084004090620059232123001905013165276000148015300010400084000125181010535501510000022228301291813704400158106062107603501677200295441850088064025008312559997122506301360000481020037294000001160000000098621473359032165171000741661450000639470001041618900010134579413900057566364000197002670026718030928723609121717614080479557137437297873580036125336643672055169115055925401584500313000830018437636112261163802237042100147173051265359003961190088380000034118300172169027918662120901770246196141421011334123000510016819700152125009722144872523061011950004451390030949118901920180143885047825193655242052285201985310347292001245889217099000178460001071500088420020539902625202420151117506012518803300002755950198023216005783030043101830351491341281306800291410001261144001119600224232000003888081102786392100004552289142670680000856601172482150213951660220111011029002520740236111173000001104124704751159079047001610761911631296417810090011501253270063741529817269869011128300350950094691000146869203301707572461630007827014108108076227012300970350079570951667200009542451148237001628938613000003906001107207100177022712411210401572170000048943314007263055690421250570044
SP120Bacteria;Bacteroidetes;Flavobacteria;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;gingivalis0270110014600059530000000000071210315129013604678120510110000005741000002200044650000000410111021386415000107380000000052000000000008100000010200031000580770001833000000166000103611500923913703700091000030390000600225025300000084066087000052109006993351348100039005700000074000837269910000000240000012200010708877015116004700008702570192182000103000360286000000158148125006613000848381020610709427823115593245001210078001021595758714211900005100089002000115062000003347400422970140095121000000000000084532650057000016701260149105029300020001192030003309724200000000067000049551472120330026100000000228143317212000005900067098003848803004100000172081188115000000830000480248003900004881000023124023619200108093000240026012100000120000930015544000037620000126000008111066001090012301603180052069004146001190015806125001861500004810572313969000002200002618000000077004401064219101290292440109002022255500024390575101193701102210003387701815021335010151182334041113440000106006206409100000048012000000545600162717900000130000000085081481960700
SP121Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Bifidobacterium;dentium0400066800001500000000087317850000091000000209010407200006711326000000000850013500000139000001660015840480000000001290166000000000000000000040800000000000001870000000013800000042001080000000880000000014580000000000770000000003400124000000100000000000271014000000000001190000000000108000000000000000000000118500046220000000000000000000000000000000005360000000000015700013000000000000000000000000000000000007100000000000000000000103000000002350000000000000760000000000000000001200000030936100010700000000000000000000000011500000310041900000000013300107000056000000000000000000526033000001000000015900001010372007217500000000387000000000015000000130000000000001270017600031141000000000000000000000000000000000001624404550119000000000018500000000190005100000001820001210000000000000000000000465600610000000000000000037084045000
SP122Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;showae00000000620000250000000064000012600730000000000000000000000330000000138000001000001500000000071000000000001330000290720000052000000000000065075200000000400105000004100000000000000000000058000006600002153410711700450000000055000000000000000000000000000000001700000000143256001170010701117230100000000029300123270000000016700001840817512415043100000005700000790000245000006400000009000000071000002750000000000000001820000000002240157001090078000000008700083000014100000000000000000197000242035000000000190000061009300120010907926600192019411212000000139310000000000000000000068000000571410600028000000007600000000666742000127004400000085021600862400010100000000135015300243002800000270310000000000200000880000000000000000073030010100131881660232000012501520371750540079650012710038174052195007600044103006177000493000000064000011908300000000000330000000064001076100540570000060
SP123Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT1380000000000000000000000000005700000000004500000000000000270000000000000000000000000130000400000000000000000000000000000000001100000000000000000000000000000000000000000000000210000024000032000000000000000000810000000000000000000003100000000000097950000000053000024009400100440000033000000115000041000500000000000000000000000000690000000000000000000001450000000000000000000000000000000000000000000000000000000000000000000008200000000000000000000000000000001590000000000000181000000000000000000000370000002500000000000000460000000280000000000000000001250000000000000000491800000000026000000000000000000002500000000000023000000000003258000100000005535000000000000000070006100000000000000000000000000440000000000003300000002300000520000000000
SP124Bacteria;Synergistetes;Synergistetes_[C-1];Synergistetes_[O-1];Synergistetes_[F-2];Fretibacterium;fastidiosum0540008600000144890000000681151000000000153920079007700530078840000000003507100000000750060000931340004700000003200000000007501560000006600810400000000133008200000000005752148000104000000007900000470440000029012710000000051000000210058003500000145000129021000157000000002510800000660000000000000162000000188355590000000363000000000000062000146000730000000000000000118002832521331267600507000002500000000000432000000233000010400000000000040180129000000000000000000020200013009201540000025762000001040000134030200000474002330169003099200028300000000033800672800038000261000000820600000000387000000000161004000000044000000000000000097012700000007556071000000009400007965072000000550150008805808400001361102800580340002000161181190520000000000001601100002600000000880004802290220006400000045005105400000413000430010204200000000008800000000004700000000119400064000000000000013773740074087000
SP125Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT2120003700000000051000092000132120000005810604800000000000000000000000000095000039000000000000000000000000000000000036000000000600000001300000381010000000181000000000058000000000603300000000000000000009110400000000006300000000000000000000000000000000000000000002100000000000590000000000004800004200001750000003440288180000191000002430000630000430000000000000000001610000000016700000000000000000000000001380000115000000000000000000000000000084000000089022400000062000000000000000000000027600167000025200000001990000000940000000000000000370000000000000000000000000000560000109000003100000172000000005000000109000000323900000008307100000000006000000000000000000000000000000013612400000000001111360000191000021000000029226500093000000000000000000000000010674000000000000000000000000000000000
SP126Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT30065270006400065388700000089029350000010000310530120910637200090010800017635000000004005768001231150042000000006900600000000008001200009281007800000000000220028021742000091000870850910390001640580044038002400005600089000177002200003900000000920000275900000320930000024011900000000000000454200001760290000000013600440007101064401630022487000002660199159061229215112001161750000014800023700001340000160001061370059000013704600080022900515011700780000000670116017068000000530550000970000132006454001070975916400238011862530023208900063226002093301780000106177219099092002137600079066027600012501470011200146026400102001090450115000042020300010801730000000208012400000029011900392200000005500350005717385300002030820009090011809000880012318900000120004008500000000810000055000000011200006700041000801071690146000145000601590001470000007300005165000046001310000360008911304986002400007400000000000000032620008100260000000350000011100341123600000061000010838001371140390620000104
SP127Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT8640000007407943690000000068000000000000000000000140000027000000000098002220002828000003700005500000047000000000000000000003100000000007200000000000000000000000380078390000000000000000481400001050492500000000000003400021047000000000004300008000005200000001200000000783020000003500000023872001930000000000000052760000012800052000000000600120008300220000021116000000000440100089002620000000000111000000000000000000000000550000001270000001110000134000000000144000000061000000002700000008600000000000000013910004400195000127000125006200000028000000000000031000004000000000001500000000000000043355615480042000000000033000000000052820000000400000030391090000000000002300000770000000294600000000000000000310061000280012000004300000440000000011000600000003337000059000000000000000000000037170000032000002700000000000
SP128Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp._str._2136FAA520108960114125003000003310280000000000000005300062000070006900129017500013990608001016101060000000001980000000240174222093180039011000500018900054600117016746009101121656300115750000200001190000000000115000121320740760000019104230029525518300001920380000000025000255016007100560079000000244510580980011000015800006801620000000001340017700000000000085201003450000000003630112160035800244447000270366003010004070861305000006400000124001300000000463067500120659005890018803939400000095003850000011704901453070000006200010700161602601770008200011743904630000298350000000000000000000160000162017400000000027800553235378000000000013300000000000260700000123600000003533175473051000033139125270000021039142000005201140403191158047000133000000239003291101900000015502591174100005501030000000000082119000001290024600000330001290490010115783105123607707600000028913100000670000000000000000000134860000045000142000011584370093552900097075314504030001772020390000029000460015501170490064001037200019450000013800065105000000
SP129Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;veroralis0000000620000002400000004000170000003706100058000072000000117008300000340000050000003800000101000139000056003600000000690000000052000000000165000000000000047038085000032000000000000000119000027000000660000000012708200080000095000775800390000036008500000000007982000000000000000000000010001150031000001111213506300000003440000512761160004600332060005000790034069000280000000000000000001270114134009074000013209700230072004300000470062107099116000215108625000000980000495200001490001343050000000334000501540004200022500026200000000002466100001100172000551670023900115730019096000019301164100404200000000000000000013349200006700091000495000000600590000000970493004951941000117000000033000650000000092000112034000002510000058009800000004900000000000000065000000000070000000108360000540062005600000000000114000153000017200000000000003400072600007800000000000000000024000025
SP13Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT247000000007300000000000000000000000180027000000006644000000000000000000000000000000000000000000000000000000670000000000000000000001590000000000000000000000000000000000000000000000000000000000011300000000000000000000000000000000000000000000000186000000012000000000000000000000000000000000000000055000000000000000000000050000000000000000000000008600000000000000000000000000000000000000011900000000000000000000000000000000187000000000000018700000000000000000000000058000000000027600000000000000000000540000000000000000600000003800000100000000000000000000000000000000000000670000000074000000000000000007200000000000000000000000000000000000000000000000000000000520000000000005200000000000000000000000000000000350000033000000000
SP130Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT34600000152620000013229333000233700062000197000021317261163001920000022362014001700096000014467010400013313500001520130206270129000000143023801530000000027016974942920040000000346600001129218111401600000161450003611916115000015445000870085000560052013600000080140096211630044000008200000118001000015085000078000957000000000079000000000000000295023733001420047129124102002470000370002020036200124570000015400002400077030501652020000003701920417149262000002020471177007006570000001650172000018802260005802742220370000651390790291028000001261670075098000000020700009703411630000453730447000214066164121001783100488711900292440146082004300122056313908500000586001040125191018623101550029731300013500000118000003561260009000470035000010113300127033000000001362670064013100000304001461025228194500000000770893910812500000180000142057970001560010400001760014000008400000225600020800000000000000015206500001200119024128804441612250023417580023700000001340129390000016515100223011229640000070196037460000000004161260019670000451371000161050000480010568187601380152000006300132
SP133Bacteria;Firmicutes;Clostridia;Clostridiales;Peptococcaceae;Peptococcus;sp._Oral_Taxon_1670000000014400450000000003517035000000000000000000000000000022000460000000000000000000880000007300016000000001790010500000000000000000000524900001160000000000000000000057000000000000049042760000002900000020000000000005200000000048128000000000000000000000000000033001760003712240000053000002500000000000000000000000000000000000000000000000000000000000000580570000000001160000000004900000000000000000000102000004507500000000000000009200000510000000001650000000000000000000000000000000000000000000000042249535900000009700130000000000008000000000000000000000000000383200000750000103000006307900000044000000000000000000000000220000000000000091000000000041000560180000000006200000000004360000037000061000000000000000000000000006000124000000250000000000000000000000000022
SP134Bacteria;Synergistetes;Synergistia;Synergistales;Synergistaceae;Fretibacterium;sp. HMT36200000560001820560000000010800000000000000000000005700000000000012472000000000000000000000000000000000000000000181000000000000000000000000000000000127000000000000000000000000000000000000000000000000000000000000134000000000000000810000000000000000000000000030300000000000000000000000000000000021300091000000000000000000000000000000000001832210000000000019900000000000000000000000000000000000000000000000000000000000000000000000000000408000010100000000000000000000000000700000000000570000000000000007700000000002000000000000000000000070000000000063000000000000000000000000000000000000000005100027000000000000000000000000000000863600810000000011800000000000000000000000000000000000002400000000000000000000000000000000370185008000000053000
SP135Bacteria;Actinobacteria;Actinomycetia;Propionibacteriales;Propionibacteriaceae;Propionibacterium;acidifaciens00001460000000002371000000000000000000000140000000000000000000000000000000000000000000000000000620004180015000000000000000000000000000000000019900000010700000000000000000000000000000000000000000000000000000000000000000152000000000000000000000000000000000000000000026900000000000340000000000000000000000008200000000000001079500000000000000760000000000000000000000000162000000018770000085100007300000000000420000000000000000000002080000000000984000000000000000000000003300000000005100000000000003360000043000000000000000000001520000000000000000000000000000000002300000058000000000000000000000000000000000001500000000000000000000000000000000015300000000000000130000000000000000000000220000046000000000000172000088000000000000000000001020000000
SP136Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Atopobium;sp. HMT4160000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SP137Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;saccharolytica00000000000007300004300000000160000019000390000000000000004700010000065000000000000000380000000068000000000000000000000000000820001620000980000270000710170000000000000000000000000047057000000001700480720000000000000000000000000000000000000030000000000000000000000000000000000000209620000000000000101000009500000000000008100000000002500000000000000000025000000000000000000000000000010100006500066000000000000000021100000000000000000000000000000000000112000000000001250000000947300000029000000000000000000000000000000000000000260000000000000000000860054000000007903500000044035000780003200986300000000033000000000000000000000000000000000760000006600000000000062000004743000340000036590063000000000550000000000000000000630000000000000000013054000270170000004133
SP138Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT912000000000000000000000000510041000006800000000000000000000000000000000000000000000000000000000000000000000000001234000900000000205035000000000038000000000000000000000000000900000000530680000000000000000920000000000000000000000440000000000000000405900000502000960000000004000000000000000000000000000000000000000000000000003900000000000000000000115000000000000000005202700000000000000000000055000000000000000000000000000000031000000000000000000000000000000000000000000000000000000000000000000000000950000000320000000000000000000131002100000000000000000000000000010800000000000000000000000000000000000000000300000220000029000000500000003200000000000000000000000003300000000000000000000053000000000000007000000000077000000000034
SP139Bacteria;Firmicutes;Clostridia;Eubacteriales;Lachnospiraceae;Lachnoanaerobaculum;orale014300000000000000016200064005800000005855096000000000500570001310000002400010001130000000000000000000055000000075000000000046000000000000720340000066003800000000078970000009600000000084000200000000094930000000000000010000000000004100000090000930004900000005400000000000020101530000000000000000350000000000000000000001860000000420040000000176000000000000000000000173065001610350000820041000019000000000000000322000000031000000000630000000000000039717604113100266000000007900009521600000000000012500000000000007313300000015100000000009700000000000000588700004100010100000006101500696401848096063000030000003200087000420003500800000530000002163025001200098000004802300000000000610000000000000000000000000000000000069000000510000000330007900000000000290007900173000000000000097000000000277100119000000000000003800040
SP14Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Bergeyella;sp. HMT9000000000004600000000300000730000200200000000350000000000000000009300088000000000000000028000000022000000000000000000000000000000000000122003100000033920000000000000000420000000000008000000000104020058000000000000000000071000000000000000000014000000000110015500000000016400000000000000000000000490000000507710200000000000001030000183000006900000000000000032000061000000000000000000000000001210000000000002900000001280000000000000000000005300000000900000000000000000000000000000148035000014430008800000000000000000000000000000001600270000280000000013031000530000000000016100000000001200019000110024000000000061000000000000000000000000000000000000000007718705500097100071100000060000000601407854001402004300053000000000000000000740080000000430033000000000000300088000260000
SP140Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;parainfluenzae003119801500000022041302616200002120780009054824000136000000066700156281420095070702210066000029000010733600526000000550021613829301010608000000531270670002070020333827500409084000000000192330435016388561000860007650006140018600000007817371905700443000124193030631621000001597185001003481840307030901331270581383036312201501140014123015401060000163020500000440250221236053928400006375600930392040043203478024800506014950113249003900115536088003870104002950000120225017272020000407002900157064100225149000074010150004410000142096418300342570000011900002513232201100016155114400001510000184044400000000048600000050700260437000000085400147118200728062101120003100063100000080275000000000015213250000111001102191123159650068019200644490000000698001301361810002230144001273363406040006090049000004133420002791260218123052100319041560289013036293119671360013101307011914449001820372300261690011854939441348770158084523500295210100043270822531803044144651909931502407066750690007101956803221105580041658000109002250123301782941351345820019814000000042678320022300632002337012008102000150218114210610590953162225902338721276071975220063940822900009693901301523402901346800050011032728086937321928100029600232009400286260
SP141Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;parasanguinis_I000000000000000000000000000000000000000000000000000000000000000000000000000000000007500000000000000210000000000044000024000000000000000000000000000000000000000040000000000000000000000000000000000000000000000000021000000000000000000000000000000000000000000000000000000000000000000000000001380000000000013300000000000000007000000000000000000000000000000200000000000008000000000000000088000000000000660000000000000000000000000005800000000000034000000000000000000000000000000000000000000000000000060360085000000000000000000000000000000000000000000000000000000000000000000000000000080000000000121000000000000000000144000000000000000000000000000000000000000000000000000150000000000005000000000000000000047000000
SP142Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIVa];Oribacterium;sp._Oral_Taxon_780940007570012884331340000001080000058014688000073009900000000171540600320400119271950004100980341171160000000000157000029000000106083001030581310000002170000000134114320000390099005900095019000000000000220000000000230600013701170000009201620155000000000000000154008800315303227880721010850000000443800922192701010001150181002900620025400000730721900000022900000156076000292055202670154004842600007714369013101202330000001363750000000000002496401230020755111175071241231008317801510000000001300000000079000000027325600601390101160015300174176150178060312800000000177147022302290082000044400084000000227019800990023600000121000000000124003160001440000112000119000920000000108440077055097628013100000136254901220030016048240000259710035269004306800126086013362774501360006602403144371540790727896052000000000680352801600003240287000520208018987002155001411831640010412354000013510600015100041990015188011100000013115114000750320070787400035000130047167045059005551850260000000470026390970414907674134078000620196042000980014460000061
SP143Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;subflava000000000000000001900000000000000090000000000000000000000001220000000000000000000000000000000000000000000000000000000000000000000000000000000000000900000000000000000000000000000000000160000000000000000000000000000000000000000000000000000000029200000000000000000000000000000000000247251000000000000000000012600000000000000780000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133400000000000019000000041000000000000000000000000000800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002000000040000000000000000000490000000000000000000000000000000000000000020000000000000000000000000000000000000000000000000000115300000
SP144Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp._Oral_Taxon_710011752000000000048019700000015500017300022000000000000000000000720000000000000027200000000480000000000620079078000000000000880000000012702830000000027000000002001710000116000000103000040025201421905700023021000000000000062000000029000000000002370000230000000000195000096000000000000000000000002000000002790000200000566090000000000000088008900000590000000000011700011200109021000000171000000000273016426010700000270009108900000003310000000860059000641420000072016400000013500000000000027979001260000000000018024508901002011560000000000233000000000000000270000440000002320000350046000000040000023000000001300000000000000000000000134000015369920000000910000001150006306100000000000000076000000751121040001470000000002800000000011500000000011500150149300000018400081000810000410000000000000105052209000125008908000000005800580000000000000000000080011026
SP145Bacteria;Firmicutes;Erysipelotrichia;Erysipelotrichales;Erysipelotrichaceae;Erysipelotrichaceae_[G-1];bacterium HMT9051534000000470000000000011130000000000000000000000000000000000011011000000000000001800000000000000000000005000000000003400000000000000000000000050029000970000570000000000000000000308400570180000000000000000000000000000004200000000000000031000049000000000000000380172000000031000000000000053005500000000000000000000000100000000000000000000000034000000000000000000000000000000000000000000000000000137000300000001360000000000000000001060000000000000053000000061000000000000000000000000000220000000000000290000000000000000017000000000006000000000000000000000000000000520010000000280000000700000000000002400000000000000000000000000000002400245800000000000000000000000250000000000016000000000000000000000000000000000000000017000005252000000000
SP146Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Leptotrichiaceae;Leptotrichia;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
SP147Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;viscosus7151026100018603714900003462580000006700470000063008018190565736871683060177319950103610700964655078002910907319252000002900680017422003713966000001051100012801230011700154020700008572134353119000462005820500000000186045120000130000550000011301850137478007580760632480002210065001860000081636046001231318122940720414000104027907310253859017000132021423817300004444610000046390000030300000034600000111370000006000024821200309183112209002702995021225000004001340112006330000155016324507570710806300185000150066119333071834027202650990029274311365015902440018152306103501350076013228300020432892502666321990026500776026595190000701808800241000228443059388192031800195057054000000000020901090000000090000154024327701600168007980033200115116000620229001012850342000006990714461209123703922940187029120944825101350020602890614906830276148204301188440016080139000237328077010522335002370001040002950052011806023640232694240041308416600119038351069007105700000150721032085075430019901060040837252191045390598521801202781320272021700081601270112403005370113000105007500521860010133479027514601172300273220171001210501054000008116416692194094145970148034714103640472080244485313146005104013106384569001080092332100800302960274200200000428089100
SP148Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;segnis0000000000000000000000000000026000000004000000000000000178000000020900000000000000000000000000000000000000000000070000000000000004180027000000004840000000000000000000000000000072000001350000270094000000000000000000000000000000000000000000000000000160446800000000000000000000000000000000000000000000000000000000000008700000000000000000000000000024800000000000000000000000000000000000000000000000000000000000000000000000000000001190000000000000000000000000001260000000000000000000000020000000000000900470000000000004980000590000000000000000000002860000000000000000141000006300000000076022000000330002900000000000000000000150000000000000002300019000000321000000051800000345100000000000000000050000000000022000000000000013600000860000000000001120
SP149Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT23400000110000460000000000000000000000000000000000180000023000000000000000000000000000000000000000000000000121000000000000000000000540000000000000000200000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014154000000000000850000000006700010000000740000000000000000000000000400019000000000080000000340000000000000000000000100000029000000039150000000000000000000002600000000500000000009556320000001500000000000000000000000000000000000000000750000000000000000000000000000000000000000000005300000000000000030000004800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000390000034002100000000000079000000028000000000000000660001800000103000
SP15Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;cristatus0002770026800148026362385200975623048000170002350100705774001880232014994000000310127300010801690005511050103179207301001820123119026039620000905810028601341240338004500652216456223100013100500821790121019200002912900006570260184758176791024120630241220002660000200170005342070370212000001672778905829924000154093101700141176000135530118901016639032136991800999527319100095000392702110012154000223014610000003970590001910177156469000235048742904207043086000190108791000001930052957548014544390183385499439248176042500029802163829100174302450882430000032271150151008201001004157694003534147142302361329251600331030014024178326344811495002100006724330602798951421282301614852804760552640407109359012200791581430002853211013660001441635302636000018000016400023415936400002344400029400177039203019420104121275904796121520199043851714510210733622014604040591425284617463617004215563000000731241710051416063001261380114801780480183011900050039272416166914800434390046551211151857705001499400000866029505989713558271541222057001309225050316001231490863270036910828001130040356050310393900209530784700348538010001032137224208900014373400687491532800123003250020301663867602312776152189115067005601212400234015132109447100525155207345000002800212039545400118000172296803662003521975001500001331073553318450
SP150Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;aphrophilus000250000205010700000000000450810000530001500000000000000000000000000030000000000000000000000000000000000000000000000000000000000051300000000000000000000002300000009000000000000000000193580015800000000000000063000000001900000000000000003087000000000000533025000000191000000001700820000000000000210000000000000000000000004600000002420000000000000000287000000000000000000000000000000000000000000000000000000000000001990000000000000000000001130000000000000000000000000000007027500000000000000097000000000000000000000000000000000000000000000006600000007000010700000000000054000108009809300000000000000250000000000000012000000000000000710000000000000001410075024000000005000039000005100000000001800000000000000000000000021800000000000000000000000055008900
SP151Bacteria;Proteobacteria;Gammaproteobacteria;Cardiobacteriales;Cardiobacteriaceae;Cardiobacterium;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
SP152Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;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
SP153Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-5];[Eubacterium]_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
SP154Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp._str._C1500000000000000000000000000000000000003610000000000000026005600000000000000034600006200041000000000342400000000000006833000000166000110000000054000000000000000262000000001680100600000000162280000000000000000000000000000000000000000000000000024960000000045500000630000000000000000000000000000000000000000000000000000000000000000001750000000000000002510070000000000000000488000000001150000000005237000000000000010506000000000031901310000000000000000000000000000003660344900000000540000000000000000000000000000000000000456000000000000017100000000780000000042000000000000000000000000000000000000000000000000000000000000000043000240042000053130000000000000000000000000000000000000000000000000000000000000000000000008100001190720000165500000000000000000000000000000000000
SP155Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;endodontalis06300000169898107000654012900010034001770081045710000530897970000169020000111840000940270000000032006265606200005963000000000015181000000002341090000077620101000013782210181850152186132000430000001330003900014300001590730048310300000149236011768003100022450000005645200000000003846000241000000580054000009677768000000001980000250000000181018028144983176002300000001214462090961880031001020401760026741430900001641650000027201120001533538201430000010605200000681770016819129415001860012400268001033964001981120093540177003512251780012004890018700012201471787321700013603910242881330272464000052221400000153000002511771740155001250015747100061617711601522800015300044002200824891140008900015800025925400000105000006060154034133700730932830002011410200107300000152000301560003715000000018308170119271220000027002220059012325700043169270021700012710200770172048200000902200750001164002600581420001000110900000000000000043006353660013446800890019767640440007600015962900000470029024821292000000025430320409359000006505201620120720002080950060000000001554762930169273000077029443
SP156Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;infelix00000000000005700310000000780634200350000000350000000000000000006100026600036000000055000000000090000000000000000000000000000000000320105005600000000002170000147250000000000000610000009700940000350008700000000000000000000000000002800000000000000630000000000000000000000013300000000003400000000000007700164000000000000000000010800001150000000000000870001740000000000000000000000000142015201290000000000000036500011700000010600000001400000149000001820045724611300018400000000001500000000000000000000025700201000720000000000000000000000000000000000000000000000800000021500000005509500000006200002500000000000400018940530340000000000000000000000000000000000000032000000000000460000000762700000000282900000000023000000590000000000000000000000037710000000000000000000008804234000010000001100
SP158Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Bergeyella;sp. HMT3220001240070056000065065000007511518270000002940000006003028007900001500712600000046038000140006741100300000003101900430000493000000007500041148005405200000000010808915503410900001280001080000000058000000576901635700002336013818000008648983256004412900000000000000000011501470000000000000520006400000000000005703804101100490062000012200299300134046008015800031027500122475201840283000000060218103840650230001772019041026149000069097000175950003912700000000000080000050000000600000127000060000000750000000000000000890118000018860017000161000000109105013000010405400045088001760000014349119066450000004500001800001060043000020514500000246041007401130000000046000343646000003984703907500430106016890005862860004000000350000056331240122000077000320816480000000721270670000000000540070003403607218201000076000144061047661300000650120001220000640169075000706934000065150033024012211004011514000000320074051000000021276601240000430000001230063140000
SP159Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT306000000000000000000000000090000000000000000000000000000000000000000000000000000000000044300000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000069350000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205000000000000000000000079420000000000000000000000000000211000000038000000000000000000000000002400000000000000000000000000000000000000000000000004800000000000000000000009000270000000000000000000000000000000000000000005400000000000000000000000000000000000000000000000000035000000000000000000000000000000000000000000000000000000000000000620000000000000070000000000000000000000000000000000000000130000000000000075000000
SP16Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;marshii00000000920000000000037300000000000000000410000004000000004800000000000750000000000000000007600026000000000095000000000000000000030001400000000005464400003800000000000230028000000006369550000000000000000000000000000000000000000000000000000000098000000000000000002700000000000000277000000000000004209100000000000000000000004900000000000000000000000000004100000000000000002890000000000000000000000000000000000000000000000000000000005045000000870000000000061001870000000047000000000000000000000000030004700000000000000000130005000000000000000124185175000420007400221010000220000001110000000000000028036000000000000000002900000000000000000000000025000880016000000000000003300000000250000000000036000002100000000130000000000055004400000000000015677900000001374
SP160Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT169000000000039000055000000000000000000000720000001040000000113440000378000000000000000000000001248900000000000038800000000000000099538700000000000000040000000000000000000000000024700011200000053000000000000000000008600057000000000000002460330000010917600000000002400000000001480000000000000000000002042700000000000004000012900000000000000000000000000000000000000000000000000000000094000218214000000006600016100000000000940006090000000000000000018000001510000000000000000000283004140000000000019700000000000000000000000000081260072037037073000000304000000000223000066000000000001160000000000480000000000063000000000000000000020800000000000003700005700000000000250000000098000052000000000000192000000850102000000000000000009100810800000034001070700032000000000000000000000000000000000000
SP161Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT22300000000000000000000000000000000000000000000000000000000000000000000000000000000000022000000006700000000000000000000000000000000000000000500006700000000000000000000001140000086000108000003500000000000000000000000890000000000000000000000000000000001680000000000000000000000000000001340000000000000000000000000000000000000000000000000000000000000000022300000010600000000990000000000000000000000000011900000117000000000000000000000000000000000000000000000108000000000000000129021400000000000000059000000000000000000000007300000370000000000000000000000000770000043000000000000000000000000000000000000000000000000000000054000000000000000000000000000000000000000000000000000000000000000103004197000000000000000000000000000000000
SP162Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;lecithinolyticum000000000601230000000000660000000000261400000000000000002560000000000000000000000050000000000000000000000000000000000840380000000000000009000000000000000000000138000000000000000000000000000000000000000000000047000001180000000002700000000000000000000000000337184000000050000000950000000000000440001180000000000000000380920000000000000000050540000000000000000000000000000000520000006100000000000007701330000005400199000000000000000000060000125000000000000740001900000000100000000000000000000000000000000007600000000099000000000091000000000000003551000041000130033047000109000000000008500100000121000000000000000018000098000000000170006900000000000000000000001540000000000000877500000022000000068000000055000019900000000000007113000000000000000037610860028440000023000
SP163Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnospiraceae_[G-2];bacterium HMT09600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000660000000000000000000000000000000000000000000030100027000000000000000000000000000000000000000000000035700000000000000000000000000000000000000000000221000000000000000000000000000000000000000000000000000000000022700000000000000026200000000000000000000000000000000018600002040000000000005500000000000000000000000000000000000000000000000000000000000000008600000000000000000000330079000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127000000000000000000000000000000000000910000000000000017400530000102000000
SP165Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium HMT15500000059091005100000004201140000000000007800000000001800000000062000000000702300000000001400000000084020300000000313900770000000000000000084001040000001960000000011312000000470000000000010800430000000000000000210000007300000000310032024028000000000005300034000000000025700000002410000000000000000004470000000011400000000000410000002640000075117000000000000000000000000000000000000000000000000024600000000013600000000000000000000000000004600000000002100000014800000003000001471010216000000000022000001060024200049300000001120000000168000000000033008244000017000000000000000000009100011603490000000000000090004700000000011065000000000000000036062003500000001630000004100012700000032000000390000000370000630035000190111790000000000280000000000004002400000000000000000000000000000000000004500001090184500009095
SP166Bacteria;Actinobacteria;Actinomycetia;Bifidobacteriales;Bifidobacteriaceae;Scardovia;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
SP167Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;sp. HMT0830000000000000000000010600000000000000000000000000000000000090000000085940000000000000000000000000000000000000000000000000000000015600000000000880000000000000000000000000000000000000000000000000000000114000000000000000000000000000000000000000276000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000560156000000000000000000000000000000000000000000048000000000000000000000000000000000000000000000000000000000000000000000000000000000011301550000000222
SP168Bacteria;Firmicutes;Erysipelotrichi;Erysipelotrichales;Erysipelotrichaceae;Bulleidia;extructa0420000000006400537500000000000041000310000960002706101605900000000000001020005900064001700000000000000000000000010500000000000000000000008800000000000000000000000790000500130000000006500000000002000000016000000000000000000000000000000000000000000540290000000000000000000000012500002010000000000003600052160000000000000000046012900000024501560000000281000931610000000000162001530341770000000009300000000000000000000053079000000000000131000001210000000000000000013500000007500000020000000000000001690000000000000000660000187000099000049000000000000005761000000000000003300008013002176038300000017004472000780380000055000000000590000000000000048000000017000000000000000000027000000008400039001700000003311500000000000000000000000320000000100379000072000000370000000000000010100000031000680
SP169Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;sp._Oral_Taxon_G55000000000000000000000000000000000000000000000000000120000000000000000000000000000000000000000000000000000000000000000000000000000000000019000000000000000000000000000000000000000000000000000000000000003700000000000000000000000000000123000000000000000000000000000000000114000000000000240000000000000000000000000000000000000000000000000000063700000000009502100000000000000226017300000000000000000000000000000000000000013000000000139000000000012300000000000000000000000000000000000000000000000011000000000000000070000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051000000000000000000020000000000000000000000000000000000000000000000000000000000045000000000000003200000500500000041
SP17Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sanguinis004472690019027034417800690208016000001125273841159547759215449423023754340146040272583019017370158562666761903304321892000117005903171761780014229661790061442700109614610172551004694853181730049063700992641530337200900900012751342015401632070000452290167799021526874237424424114038700006923884001000585890191040001121262322465036983041377001222802102135259816725850004933316278252100662461534079814683281200424963191405001134254012606013061262116050935005883241330230000194242012198109000000011600024538434248612506550001010720003331086126111300101106428933016401213059314940091601920781001862002126524508530032506501828205816933724153500002740003840011744503082811486011300002429630000000033100039706371770907650367042000007161314193515441610000080900002505942502100000000030200045800003136260000060328510006759010001423330482000000232927000000000121405268948000014110743250012370754033422602780028501100849301922568040310560417136019830000131087489517858127509437961766016600440205216775012932300246032500010200607309633059313485212606810001953729024222063207734500159127141459111729115040052122047532736290150099173251063561000371380139097112802411194366230235912304345468213691152460329055196417241001684114003441000303082502140176769135610228763901201702019803056137171850487271030516400413290000054066338582521044469917631210460194489147718621511290496030503700001391584119583021101088888300060455664116380450000035163313390013561015483001903660022913611748203877540
SP170Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;odontolyticus069006500000000000000004890116000700019620000000025501520009100000000000550541590000027100000000000890014213600105000001690010400000244009801420001680000000000000198000000000004400022900660085000001461531140000000010700000004700000016278000000088000009400000000000012030000010400650000000010501050000170000000000000029000000019500017200000000000000128000000029702720000000000000000500000154051000000000000000017300000000000000000164000000022300017200000000000001170000165000002211470000000094000000011239700000243000024433300000116000000096004060000000000000001030000000000000000000254000000606801010000810001100018700000001210000000083000000319141875801030000006400000044000000000000001700000000005100008000000000000141001240000600065520016820000012718800008400008600558300047000000001370000085028508200006500004200006610812400011800000820000011779117400000073005413509606804387138
SP171Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT1710010560010640015400036001020000007100000000000091001602400560404500323088720290142000143035600107000000361072700001311190000000216800127000000032145670000000210061200000000040100000440037720820000000004900000551426000000000001374059012300001060000056000176239037700032043900081001300099021000003660150005710000038400432001600000000000005999551300000000000014800000000000560200000150001555630000000012200436009500040000012300350007000002023440000239002620000007010000000000009190013900000017100001115300235000000000253000000000000000001024290000000233000002100000266000000007003602400015302500000000131000000000000017400000000261272083500008299000000770000000000000057002142170800870610250000250006500003619000010900015800001740000830443199000000530031900128534862116026011600002629136017033000880000000000914589228740001270004393750000000000001840000786000410003570010820700000857035073000223511280541461360000142003920630048000000000053094000000000274006700
SP172Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;naeslundii01390001190000000000047700000000000000028200000226021700000000000188000000150185680000000140049000000002580188000000002700324002710000000068001780000000001200537630000410000000025550026707200340000037701361541160000028359000130800000000000000000000000000000590016600000017400000215000650000065000000170018017400000136252002950000000001640000001020069001345600000608000485002561540000188000005700000000118000000000191053700292000000000000000000000000000255000000001650001830000065000000000000000000000000000000000128371706000000000000000003000000484000376000000021500000000005790000000000000000000000167055800000004400000032845911972001270029606630786434840000000000801240000057071003160000000000000000009900000001047014500013503610000049608400008800257600037001201414706064803907100375150000002186101750039600236000002160000880000004760000000000000037100031900090000000000000485301800108041426000000141
SP173Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;periodonticum00000000000124000000000010000000141018000000000000000000000009100000000000000062000000000000046000000000063000000000000000000000000001140255000000000015983000000000000000000510000000000000000240114001150000000000011101990000000000000000460000000000810460000000000421000011500005130000000006300149000000000000000002450000000000000000000002060000000000000000002250000000000000000000000000000000000000002520000000000000000000000000000000000000000000000000000000025300000000000000000000000000000000000000000000000000137000000052000000500000000000082000000008200005000007100000000001980000000244011400362000000000736000000000000000000000000001250000000000037321740013000000000003020000001130155000000052006810100000044000115000000000000004100000000000000000000000750000000000000235
SP174Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;histicola00450000810000002500000000000000000000000001260000360000000000000000000000000000001900000000000000000000000000018500047000004668230000000062000000000000000760000810018000000000697800000000000000000007500722700000000000000000000000000000000000000000510570000003500000000000000000000000016600000000000000000000000000138000022200000300000000000000000000000000000000008700000000000000000000000000000000000061312800000000000000026000000000129000294270039000000000000097000000000000000000052003000000010800000000000000000000000000000670000000000000000000000000000000000352242500500000000000000082001010000000000000000000000000000000000900000000000000000000000001630106310027000000000000000000004400327600003100000000000000000000000300000000000000000000000
SP175Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;anginosus10318678048722679871795723000002120077291202000000007372057391662861040330001000001130254022800706010039630022900215005144933000006120000780053011701221136243000354726900150057800371151234200098319160488200169654434115600647001580116063934548110110311102202800649313313000013003702260483110117000002061450000001590115001691550562200075234482415214458002248266900700000000040606017200021310702020952759527500001880002771930520018524960244144304902001398920691455289257100027023370000001318380000012660004663915629245314120018815200343000398075104790013591520012416451330008007025011920710015600388064901820305940003000136117400076464302891590236155000070031525048414063102410033274018617808460001432418861150028150088231700010200030033529150186818000012630019007504680000346234018100002020106002090114700113803550000400234046110053305769570014000141167010150116152117529312807500008522204680300521640010101321205302016704013207811761014711845500261711050001360000048704000023200000053145238350690036220201617700020004544716609755900116650000025011528400591741911661182962849940370309134810400180555000052074340011814525126000000491312381751000730023051003130527500002761245505825157462200000006300000619007285110173062451
SP176Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Kingella;oralis000247000000000390075000004610201090091006150002400056000004600670000000001602791011100750930022403700087000153730000200000018200023000018008611411701270000007800040000304017161016403112800000000000000000000004722840000143732462438184000010601190004000480063018792142106007253810011123967760330000461580000060000920000000012100005030615106020500000000000017210002000107203744461314000000013204303790109000238013100042301840000000000000022500189000383000000007714700000000000000000017400040010500237000000000000029000000048500001230000000800501190294000000000033007300006700000020000000000152064119000000011055000000035101752910114005240000059802111150063302901104807706504280871010394400360069129000327345311716516805509041020114372100219113593751000000950105133016301670138132002032006400017202201721040035999044203137178997209500031800079250002421100970320443728630290118002300290680000057018214835100000173801391730138775600253204901121561293734559728204125439054526424000010759070000380765900802600065181161117794880053000240038380000
SP177Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;sp. HMT03600000000000000000000005900000028000000000000000000000000000000000000000000000000000000000000000000000090000000000000000000000001205700000000000000000000000000000000000035009100000000550000000000000042085000000000000000000000000000029000000000000000327000000000000000000000000000000000000000000000007900000000000000000000000000000000000000000000069000000000000000000000000000000000000000004700000000000000000000000000000000000000455000000000000000000018400000000000011000000418000000002100000000003029000000000000000000000000000000000000000000000000000000004300000000005603700000000000000000000000550200000000000000000000003500000000000000000000000000000000000017059000000130000000000000001700000014000000000000000000000
SP178Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;lingnae_[Not_Validly_Published]000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002130000000000073000000000000053053001210000326000000000000660000000000000000000000000000000000000000000000000000000000000000138000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027000000000000000000000000000000000000000038000000000000062123000000000000000000000000000000000000000000000000000590015400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SP179Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;amylovorum0000000000000000000000000029000000000000000049000000000000000000000004900000000000000000000003800000000880000000000000000000000830000000000000000680000000000005400000000000036000003400000000000000000000000000000000000000000000000000000000000000000000000000000000093000000008100000072000000000000000000000000000002160000000000001550000000000000000000000000006300000000000000000000000049000000000000400000000000000000000002480000000750000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075000000360000000000000000000000000000000000000000000000000000000000034000000000
SP18Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp._AF189244.14365025500840001990031162401401420000313840037903600020800108016495057000068130450000380000018085805065017000000881140003390035301200135014300000000005300002020000087000000000106008500016861016516181010400000240002516001240000012000043445100000004616013700005001310011900239001145401250050000157960005800192035000004400062116000000284041000000006060407000000000002000000008206710219000100000910436000918511200054174118461740239000802100000139000212001581230223340001508948605002057768158150092000000000001500294000000000980000190017100034100000037000000000000000687317139010300000000190000014516500000000130105001210000527003360000163000000113195002561720000383600000000020310000180000006300003708760360000000000223405740630000330097085000003757000000000000000002810101039086169015222337130182015261023301240275000127089750012200000000012000260078003833292408000000000795100000191911135125000000022004221140000002209901641620175008604037500000120390000023100000000237000620000138001812200000000001870000
SP180Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;artemidis000000000000000000000000000770022003500000000000000000000000000000000000007400001380000000000000000000000000000000000070000000000005003700001010103000000000003000035000000000074000000000000000000000102000000000000017071080000000070000000000000025000000000540000004300720000000000000000000000000000000000000000000000000700000001000000000000000000000000000000000000223000000000128000000000000000000000000000000000276700000069002300000031000000900000000000059000000000022000001710000000000000000000000000080047001833480000000000000011072000000320030000055005800250130006418000000000000000004200034000034001120000006204700024200000180000000030031000000560000166071000000400000000000000000000155000000011501900560000000000000000013002200000540009000019000005501600076000000730
SP181Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._Oral_Taxon_17800000000000000000000000000012800193006605000000000000000000122000000432207400121000810240005225000000000000000810000007100006000000013900019005500000000012001550043000006100000000019395294700000005765000012113000012400620000008607800720000162000000078000000480000000011933000000060000000019400000099100000180001540001570000000000001260012900000000000000000000000000001950000168000003520000000000000000000001030000000000002130000000000000000000000000000000000000000000001050010100000000000000000000015200002778216922100000000000002190000000001350000000000520220200000000000000031000000000000051008018000001660009906500690000011119003800000800010600000000003101600000000006600000000011600026000000000019000061073000049801080000053024657500370012810200101000008906400000000000000000007500000001220000006600000000000017000000088061910
SP182Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;bacilliformis0004200000000000000000000000000000190000000000000000000000000000000000168000000000000011800000000000000000000000000490000000000000000000000000000000000000000001000660000000000000000540000008100000000000018000000430000000000000000000000000000000000000000000000000000000000000000012600000000000000000073201170000000000000000000000000000000640000021800000000000001343000000000000000000000000000000000000000013000000000000000000000261700267000000000000000000000000000000000000000000011200000000000000887100140000000000000000000000000000550000000000000190000000000002400009113000101000000000000000000000560000000000000000000000000000009600000070104000000000000001890001010021011810000120000055000000000106000000007101600000000000180000002100000029000460000
SP183Bacteria;Firmicutes;Bacilli;Bacillales;Staphylococcaceae;Gemella;haemolysans000116000000000380000000000000002280008000000000238000002809211200830000075000000570000000000028000210846000001700002170011408300000000440000000000014700003217200125074000880001540065000000038000016350000014126200000040000001260000000000064239013900000000000011300000000260135083000000720531110000004600000000003610660000000000000000000000043600000376000000040601122619400125000027900107045200261000601153233500001130000064025900000135890000000192043700000247000009270000000026600000000002750002720000000000220590000000000000000190004320900000004300000002600000529072000000000044000133101000004300080003500000000055690000000006613800001130000000000095020000000000018000780000000000000000000000412770200000000000510001090009225013047000540000580000007101130000000000000000006407290000000027980000000001330000006901060075007300000730390000001120124004100044000005602587005400
SP184Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;pasteri00011000000000019300731890000134000066166018400760000108000160000000000000049000580000112000000000000000000000000000000000097004300137000000000785500000001110000024400024000000370000000137033000000000019300000028010006704118200000000059179008600012111351000000002160000000001020100182000084000001640009700000000000000600000000940330013300328038310255321117000287000003340280001606000000001770000000000530004360002155500015190000000097000000000000000000000197730000000050000000000831240053000020300004810000000023100518600208000000000000000154047642192710000007301900082051000042002072410021900000000000001341410000000015530171000000000005700000230006600000000760000000000310166000000062000000000049720000000000008200000027000500372000000036000500667001240000004805000000000000000000010959052112000000950002100900000800000001886000000037000000017400000000000001707800620
SP185Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT913000000000000000000000000000410280001470000000000000000000000000000000000000000000000000000000000000000000000000056000230000000017200000000000073000000000000000000000000000180000000000000220035000000000029000000000000000000000000000000000000000093000000000119000000000000760000000000000000311000000000000000000000058000000520000000000000000000010300000000000000000350111000000000000000000000900000000000000000000000000000000147000000000000000000000000015900014600001070001620000000000000000000000006800000000500000000002800000300000000000250000000016000000000000000000000440000000000000000000000047000000000000000005500000000000000000000002600410000000000870000000000000031000000000000000000000460000000000350000000000000015004600000000
SP186Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT332000000000000000000000000000000000000000000000000000004700081000000000000000000000000000000000000000000000000000000000000000000000000000021400000000000000000000000000000000000000000000000000000680142000000000000000000000000000114000000000000000000000000000000000000000000500000000000000000000000000092000041000000000000000000000000000000000000000000000000000003690000000000000000000000000000000000000000000000000000000000000000000002110000000000008200000000000000313000000000000000000000000000400000000000000000000000000000000000000000000000000000000000000000230013100000000000000000000000000000000028000000170000005700000160000003900000003201170840000000013500000000000000000000003300000000000000000006100190000165000000
SP188Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];unclassified_Peptostreptococcaceae;Oral_sp._str._CM5000000000000000000000012000000000000000000000000000000000000000000118000000003067000000000000000000000000000000041000000000000000000000000000000000000000000000000000000200010700000000000000000000000000000000000000000000000000000000370000000000000000920000000000000000000000000000005600000000000000000000000000990101000000000000000000000137000000000000000000000000000000000000000000000001630000000000000000000000000000000000000000000000000000000057000086000000000000000000000000000000000001170000000000000031000000000000000000430000000000000000000710000240000000000000000010000000000000000000000000000000000000049000002100003300000000000052000000000000000000000000000000000000000000000000000000000004933000980000000000
SP189Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Olsenella;sp._Oral_Taxon_80743441200805533020461295168485106010500005690463000004180000238119039417106532205017300083036800000177034605864652380394000754358002151679501811681250121102000002490369035067013308400043190326215136000000342670731320125000419301214019600000021904610330062010920149512197590399048122002881180038402350160003458200106003962374850194000384014214300052057800241002491970090000970308000000000293015600142287008304420000000000000000000000000000075006200479299000520527063818439600116360000000000015270000036700000003934200000000052200057632907370706002590622000000733000000192159000101954002300000291000001865377850018400892910036502141700000000010320006801220044520410240237003990782009006830360396000260005570000045933674454000000411326603170223006680596016600000000037000031800067065115059603671001590013002700006800038212233921720501740433540000281671365030015505713137130129802105960108003652240147135025616782050908823484901680277024801300124750309001850223000609023509318383421760010178015278004161392388000329015300012763028029517927903052498021735039837500001490214084315328382312020826711003200153753500028203363160410153003330309000498000094000490573193000021202553003590620205000039001340980149251179407802583249003850140250
SP19Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_ss_nucleatum0000000000000001250000000000000000000000000000000000000000024000000000000000000000000000000000000000000000000000005900890000000000000000000000011400000000000000207000000000000000001700001000001394400000000000000000000000000006400000000000000000000000000000000000000000035600000000000000211008800000000000000003400000000000000000000000200000021300000019300000000000010300001420000000000000000000014905900209000001870000000000000000080000000000315004718400000000003314200000000000000000000000000000000000000003400000000000000056000000000000000000000930000000001560970000000000000290000590000400000000000000000000000000005000000000000002300000000000044000001150000000230000000000000000000002400030006700000000000000000000000000000000000000570012600000
SP190Bacteria;Firmicutes;Bacilli;Lactobacillales;Lactobacillaceae;Lactobacillus;salivarius000000000000000000000000000000000000000000000000000000000000000000000010100000000000000000023700000000000005100000025000000000000000000000000000129000000000012400000000000000000000000000000000000000000000000000000000000000000000021000000000000000000000000000000000000000000000000000000000000105500000000000012000000000000000000000000000000000008500000000000000000264700000000000003560000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002350000600000002117000000001480000000000000000000000000000000000000000000000000000000000000000000000019000000000000014100000000016000000000000000000000000000000000000000000000000000004400000000000000000000000000000000000000000000000000000000
SP191Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT22100000000000000350089080000000000000250000000000000000000000000000000000000000000000000000030000000000000002380018100000008780000000074000000480000000000391590350001950000000000000000000004500000000004000340000000001250000063000000510000000000000000000000000000023900000000000000000000000000000000000000000000000000000000000000000000000178000000019200000000000000000000000000000000000000028000000000000000000000000014400000000000000500000000000000007800000000000000003300000086268000000000000000000000086000000000000380000000000000030000000000000000000000000000000020008300000000000000000000000000000000000000000098000000000001170000002400690000000110000000000009500000000000000000000520000000000001080000000000000000000000064000000203000000
SP192Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT27000000000000410000000000000000000021000000000000000000000000000000006510087000000000000000018000000000000000000000000000000000000000000000000000000000000000000000000000000000002200000000000000000000000000000000000000000000003500000000000000000000000000000000000000000000000007300000000000000000000060000000000000000000000016000000001600034300000000000000820000000000000000000000000000000000000000000000000000000007900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000900000207000000000000000000000000000000000530000040000000046000000000000000000000000000000520000018600000000009000000000000000000000001400000000000000
SP193Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Micrococcaceae;Rothia;dentocariosa24253821647335991074021725590791104742372188586323434153604726022334149606511637271116313480000716362152083245570376410766604887101678260122419483432176552419514820364301818317091241201292255160011171107294479223342686017247096390504178708623392331712513504540138512912381058935030138272299466901909729186543034037030581073463748955244197359314404501040010470461058857414911371377651111873003610002266124500001884817631664840100911241233002232377398012833881147924205269214225774758198434615401152946271382995401618801506485882481406469022112364159061811731120333611754957351673560317255271413421137318661213442226911113999346148181243171460298469028090277358048252832322528611631263300263000109870566302029100237621251100518892386980103600279743303344702736521024454257172822148722513718631491875152098156011941855321851248396100344537693763183115236067003197880407360073301821611317627601535031001534414523877220120165010510101812473001380148618340437259021101295380621803181592230336619050369040038022450113217502112661651718019213401238042112312917140016148501988297425251000279131010379501051162047457521083000008287000000130805271655239327097740008850854657361312603116200336945023501762510037600316228707577104422115023938630053841051276804701819053658431859335811599882952527147434440150015712673141923391423161551487754196104182873747339834461649610145119236108871087241605382707034093356385506810522387336668820022300677323121341224198560012986520532894026350634520489095406799861013724293241967051010473880223334382914930235486472817261211862721313153352954952761933857417534068160932214894671336037291722941841494411214588933914266891351295144662156061875904072954105468045611955968770058833039310291762018960977555127419960269256761292178180986887048399511686622921955141087308141476602640415100311671268283215583135026728499153681930338083817936761187312183632869235910011043815220260845846688913721198471896109114824355686032041253774220844031262984800
SP194Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;sp. HMT3700000000082000000000000000147000000000000000000000000000000000000000000000000000000000000000000000000660000000000000000000000000000000000000000000000000350000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000020800000000000000000000000000300000000000000000000000000000000153000000000000000000000000000000000000000027900000000000000000000000000000000000000000348000000000000000000000000000000000001700000000000000000000000000000000000000000000000000000000000000000000000000000000000000035000000000038000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173000000000000000000000000000000000113
SP195Bacteria;Firmicutes;Clostridia;Clostridiales;Ruminococcaceae;Ruminococcaceae_[G-2];bacterium HMT08502000000000000280000280000000000000025000000000000000000000005600000000000000000000290000000130000000172720000004000000000000000000000000000000001254800055000025000000000000000000000005300000002900000000230056000000000000000000000000000000000000000000460089000000148000000000000073000000000000067010200015000000000000000000061000008000001260000000180000000000000000000000000043046000000036200000227037000000000000000122000000980000000030947400040102000000000000020200000004400091001220000000009800115000000039000000000000000000000082000012008700000000049000000000581130000170000000000000033000000000000000000000002400000000000000000000000000000000000000000004712160000000000000080000640043000071019000000000000022000000000000970000000003600000008000000000060080000137
SP196Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;sp. HMT8087642000000550000000630680000088039530000000750570000031630050000000000000000008412700003501014100000000000640630000000099000000000000000041000058910000000000400650410001950000120000000000000000000000000000761500070600000006500000000000000006000000000000000730000170000000000000001070115001430001500000000000009401160001600990544000000000080000000013400000000125000000300037106086000000076000000640000000000010300060002900000000000000000000000000003510000018400000000510004000001340000000000000000000003460810000000013300000000000010800000000000490800930000000000420000600003900004300000000000512300181720000005000000000000080000000000008300230000000008000280000028001800000610000000000130007600004631005700000000916306900052000000021000000000000066000450000000000000000007900078820000000650000000000000000
SP197Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium HMT129000000000000000000000420000000000000000000000021060000000001500000000000000000002900000000000000000000000000000002600000000000000000000003700000007600000000240000000000000002200000370000000000000000000030000000000920000000000000000000000000079000000000000000000000000000000000000000000000003600000000000000380000000000000000000001150000000000000000000000000000000000000000000061000000770000000000000000000000000000001400000000000000000000000000000000000000000000003400000000000000005400000630000000000000000001401903900000002200002300000000000000320000000003100000000000000510040600000000000000000000000000000000000000000000750000000000000000000000000000000000000000830000000000000011000000000000000000000025000000000000450
SP198Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;vestibularis000000640000020018701900000000000059300000000000007700000001930000480018110500000000000117000000001646000420067122000003640000155000098000000000231000000182002510530000000002060001010000000002400000034000083060025200000000076000000000000000000000000114003861000000000000000156014055800000000068000000400000000000000000000285000000000000019100017400002900000000745001150000000000000249163000000000000177020401360290030601010075000000000000000000000000000000190005920000000000000000000000000000000000000000000000000000006700000004320000000000188000204000001070000066059000310000000000007100019603210900022917800029000001650000006700000000006704101490000000000000320009303270580000001370000933886058004976000020064004400041000000000002710000013800000000152000000015100000304000810003000069107005400001536001638004600200000016125000910064550000000000660000000
SP2Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;fusca00000930000000000000000000000000001420105010100000000000000000017000000001520000007014600000000000000000000000110042001030000000041000000000018200037000000000580000000000131091076007400000000000000000000000000000000000000000000000000000000027000000000000000000000000014700000000000000000000003452180002440000000000000000000000006900000000000000000000720002830000163000000029100000000000000000110880000000002850000000000000000000000035100004694000000000157000023201150000000000000000000000000000000000000000000000000390000000000000000000000000000000000000000000000000028200001080000000000000000000000000000000000000007600000000001330000000000000000000870004100000012300000000000000000000000000000000096000000000000000000043600000000000000000000000000000010700646
SP20Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;sp. HMT2040000000000000000000000000000000059000012200000000000466200000000000000000000000000000000000000010300000000000000011700000000000000000000860000000000013700000000153000003400000000000000000250000014600000000000054000000000000000000062000000000135115000000014900000830000000000000000019000000000000000000000000000000000001300019000000000000000000000000000000000000000000000000000000000000000000000000000000000007600000000000000000000000000000000900000000000000000000000000000000000000000127000000000011600004900000000013521700000009800000890000004300000000000300000000000000097000026017200000000000000000000000000000000000198000000000000000000000000002900000000000000000000022200000032900000000000000000000000000000000000005100530000000000030000
SP200Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Eikenella;corrodens0006600000553903000000000004200000072160000003100030480000000005800050000800000000000000000000021046000000001700000007600000000012300002700001020000082000000890000000000000154000000000000060000140000006300672345000000000420000000004000000000000010000000156680000000000030565990169000000159000001620002360015100000000001760012400854750303122000000000111730027500002210098000000000077000018000000000174000027000000000000007400000000000000000000001390166000000000000000000000063011200000000085000000000000000000091481460007700000043000000000910000000007200170049654900073094000061090000000021000630058590780063006100342100001260000200000047000001038400051170021000000790019005078000890000000000000630410000001590103083030330670000900009200118000001280003300826561180491149600086690430059139010806700000000013033290000000970003300000000746900000870420056000
SP201Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._str._ChDCB197172103138500000018814800005030006900083000328004410000023101130109760208022603020000000192000429000252624000271107004852910000000153728012600003870164825505700510836600000620255000093841081270560021500001310000315500004400000000079032308803181561230287982218402160014202140772797000000002530000044820864501870017207603619682808008660660000030431653100083000000001230000231337900000099100244000000003387660060000219000637900000145016500002860184004163980326347608881000123032000114000890110136022242400000169140800213000005272114090005800090867000010000019820588055001070289000002232453010000508000149000037700011625500000000000034395000634000000017900920029240400729090400821160166000000001550265000530331000980878002805160026841132300324000810002811110000001426944541152003850701001080720680000010401270000000881913130118490880000704241001240965044384780021323000000022526700355200397044905940830079404300000162311304280638000003850013169170000126753110680000230000000000010412000000061014500154407000000009801761002871022884294306000343060006400155002030142860010702291750000472528001660660298000039000001500000
SP202Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT3479402030000000000001170000000006900009511900006346168000001290002230000000000015022980001680330680122000136560000000000001567108400005360000001743599608100051006100000109001400000031000980330013485000005400041000000000000000000000000000501132884290001260000850000000001791571200000014100000051000000000128000000067000000000066797141000839000000098800000000000016732200000002540094000000003770000000296000000013400000000010580000067000000006520000000000001501640210000014900000001927000000000112320000000000000120000000494000000000010800001710009800000000000000000000000017300000013500000000000292065000002060009900140000011800440010900000001530001030073418578211000273207000000000000000000000000480009100049300000700337630000606412409200084002900000020500007024900000000000560047154002761168000000580000007400000011064000112005322801070019200033711167000000507305743000000000074000000340000000195080200
SP204Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;multiformis01700000000000001020159000245100000000000000000000000000000154000001260100000000207120000000090000000000000000000000000000000000000000000000009600000000000019800000000000000000000156000000001510000000000000000000000000000000001070000000000000000000000000000000000000000100000000960261000820000000890000000048000000208800155000800000000000000021000000000008910000000000306000000002030000000000000000000000000480000000033899002230000025700391000000000000659000000104104000014300000002200000000215000036900000000000000000000800000000000011606700000000001270001310000000000000008700001150000000000000000000000320000000000000000000000040600000003600000000000000000000000000000004300000000820000000000001160000000000000000000000270015000000000014400000000018103920130112000000000002604340000000000
SP205Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;gracilis04840017132048002000480201489251018251970088044117005217958377123321321170170403075152092012572007109500273740133766501671040378906218822010911314452000125019102210770410021401351731020011880011211160007401676455970135010101790126002420491978061707600002072012675130931550006100056046090000016016881412901170331590170160013101397509109600650600013900110001210120047932187000061890751131710114240139006300134010802142770007913803260025017602492880172198206003801870147197015529901184580170034304272043251783515421400139166004500228173000128200011935065492120002452490302590011622301892596204690038811030324210825817800001281043125230131501440012811015934211200570123001671121433242240011302991731510650169021610631625809997300151001311730218486183419264332389744680046911610018219801420180053123311921790363001180014501001510130219015002574060021729501222520064232232216106128969922112014100150003600132717639403101661129414452113025263114121220160142050011859690950228001150012318619835812956981721671111281276030137000164097136850146224903917811501890131248740156012002141871727734434341081072261415709112401691711348779116938412905510069698120808823763228985507209694007349019526572212801972561081391918329514628014901764898144150167278141230751320786134811491002161281231490671415616218031614313951148939885058082036288008629333121104000141646508910314910500577836981401247901401257399351142761362812063
SP206Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT225000000000000000000000068000091450000000000000000001330000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114050000000000000000000018477000000000090000000000000000000000000000000000000000055000920000000000000000000000000000000000000000000399000000001679300000000000000000000000000000000000000000000000000030000000000001110000000000000000000000000000000000000000000000000000000000337000000000000000000001670550000000000000001490000000050000000000000000000000000000000000000000000000000000000000000000000000000148000000000000000000000000000000000000000000000000000000000000000000000000000000750000001400000000000000000000000000000000000000000000000000000000000058000000
SP207Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT219000000000000000000000000000000000000000000000000000006200000004500004000000000000000000000000000000000000000000000000000000000000000000000000000000900000000000000000000000000000000000000000005101370000000000000000000000000000000000000000000000000000000000000001400000000000000000011700000000000000000000016400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007400000000000000014000000000000000000017000000000000000000000190000000000000000000000000062000000000048000000000000000000000000000000000500000000000000000000000000000000000000000000000000000000000000000000064000000000000000000000000000000000000
SP208Bacteria;Synergistetes;Synergistia;Synergistales;Synergistaceae;Fretibacterium;sp. HMT359000000000000000000000410000000000000000000008800000000000430000000001000000000000000000000000000260000000991610000000063000000000149240000000000000140000000000000013700000000000000000000000390000000000000000000000000000000000000060000000000000000000000000000366000000002610000000000000000015400017400000000000000000002630000002940148000142000000000031700000021000000000000000000001550000000000000000000000000000000000000000000000021800000000138000000000000000000010700000000000022000000000000000025600000000000000004200158000000000000000083000000000002900000005800000003100005500000028000011200000000034000066000520007600000000000000500000000000000033400000000000320000000000290000000000017600105000000005800017400000000680000000005300000000000000000000000000000
SP21Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sputigena0156000201430900022510301100001391828927900015200000771581096995255065000041000009400061083891171582301400001731800600002036100899400000117023504474701730011800260014501521800750024680002800015800205211010462069059000191085772500039010410106300119017710576165000000046860006518200281292820680009200760001540216000001850005002212056074136044000470049000160513508003970000051811201330099000536502590000000891660012200482015920305403750006000023700001424060600003081040000036403760010100012514818411108406402110044051158574125737700051400060001734493130000890068025702120271010421101600850000328413326001680256008304330001280066511040512216825601642830687454378820401470025800219000113191442004222940000290870005821450134960271167134025733319687088011401120179060950580023801060000000410022805311400018000590171775308211526013270198038760002900103003720910340033650726500441780625407307503200761760049840190940000001430010002091710000048111617666004944029580014100001500480000850001670100049325070001980230020000298400112100539903319800015601595900037004243502100000000000144036214000063019816298000570003900614035723105025114603714300270189131
SP212Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis_subsp._tigurinus_clade_07000000049219947430000015800003180000001800001220000000083000010303816017901376000028005845901090123300014800000001130247000000017000024349114113513903074000570161040616800244070202084912770032002840000225300200101700001110189027245200912401041013021304144117000540123870200112230008000000000000050598400000000052000000000000000005891222000053052000581102802428400200001705200000015614100260102982415004670000280012196482650007805200057741221068001460026063900048000019920990786124465728607045014201038400205420166710326350440112600000272000001902300238100000084960402504581500717206901690440227032700878048013464521061000009400007351401232741152000024722211469221100205943215277219830102202466800022030000074000038300000444000003481875000020600000126026900510900131221100001606939040031000006503451000281732320000200001010530110701990433120683036219026152000090480008410026000000009700078000000930010970007905000001600182585700051007630661000037000000330098414252552222200072000001480003400079902090152500041001410000320000297670009504400063960001005650000001540408128000262001160250128044351717970405104866
SP213Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Oribacterium;sp. HMT078076000000000015000000000000000000000000008100000000000000000000000000000000000037000000000000000000000000000000000000000000018100000000000000000009000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052000000000000000000000000000000000000000000000000000000000000000000000000158000000000000000000003450000000000000000000000000000000000000014700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000590000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017000320000000000000000000000000000000000000000000000000000000000000000
SP214Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Bacteroidales_[F-2];Bacteroidales_[G-2];bacterium HMT274000000000000000000000000000000000000040000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000060000000000000000000000000068400000000084000000000000000000000000000000006200098000000028690000000000000000040000000000000000000000000000000000000000061000000000000000830000000000000000000000000000000000000000000000000000000000000000000000000000003500000330000000270000000000000002600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000370000000000000000000000000000000000000000000000000000
SP215Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;sicca0006500000000000000000021503200000000514000000000000000012300064000000000000000000000000000000001458000000000000000000023000000000004100000000006300559000000000109000000000034949000000000380000002150572000850000000037007100000000000000000700000000000000000000000004450637000000000000000760000000010600000000000079000000000000013800396000000000000000000000000000000000000000000000000000001451000000000000000000000000000000000000000000000000000000000000000000000000000028900000029900000000000000000140000000000000000000000000000000000000000000640470000000000000000000062000000000000001230580000000000000074000000000000000000000000000074000000000000000000000006600000000000000420170078100000000000357000000000000000000000000000000000000000002100000000000
SP216Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Atopobium;sp. HMT19905600000790000000000000000000065000059000000000049000000000000000000000000370000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012000000000000000000000380000000000000000000000000000470000000000000000000000000000000000000000000000000000002570000000000000000000000000000000000139000000000089000000000000000000000000000000000000000035000000000000000000000000000000000000000000000000000000000000000241000000000000000000000000000000000000000000000000000000000000000000000000000000000000082000000000000360000000000000000001700000000000000000000003100000000000740000000000039000000000000000000112000000000000000052000000000000000000000128001540000000000000000000000000
SP217Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Lancefieldella;rimae9425403704500001131210790001052301900056000000000285000200208069045010507609000000643000172015001871450001808300175181001029400530000213010800340000013716300005300000294000009000001910000000003250223025500000008700107014000005800100000273002279003990117139886100000801574300013776361960000007710012209009630501400027100004100000011989000014300000072010400002690004580000366001668560000000020701661981855900001349464200000000000000252016520037900000000119084006450033600015231600486420000000000569030900000090000192000203005850001670011560447600900028700006130000008962807621500000000623205083136970530863005830901150602000000005230017903320053200238000028800069902570000088459400023900000124030710141001980154003030020007218024202900015221411053460005448100660668124402750010903050371941899602700000867802380840228021401110000003600068001100610014600348021707714010100034214300360009266545007900154000933805001510540002338435221014100000001150592330899640126477200101019365000006416600000064532430000000760102000000034902583809200000007803424218079001795011600000
SP218Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;sp. HMT286000000000005601560025085000370000000760000000600000000000000079000943900380000490000000000074000000015400000001300001900109000000000000000070000014800000150009000000000000000000188005600000009400000000000003709800000000010900000000000000000000000065000660000004505500097851061706008400015200121000000027100029000000000551000075540004618192000000000570000113000930000006700037200000001400027713705200181000000000030000000002000000014202110012700476192000001390000000000209000052380229134000276001170820001320000087000010100106000000013405400008600001170000000379000000012600000008100000001211161160000000008300540000180000004127000000028044000000009506200000014300000580000020550570041006900000000000000000000000000000000000000045019079400116000044000114820047008600000004200860010400025320047000040000000000000010900920000082016000000000280134028000008000000108
SP219Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;australis000870000000000000000000000000000000000000000000000000011300000000000000000000000000002900000000003150000000000000000000000000000000030000000000000000000000000000000000000000000000000000000000000000000000000000000270000000000001920000015000000002000000740000000000000000000000100000000100000000000012000000000019000000000000000000000000000140000000000000000000000000000000000002400000000000000000000000000120000000000000000000000000000000000000000000051000000000000000000000000000000000000000000080000000000000000000000000000000000000000000180000015000000000000000000000002900000000000000000138000000480000470000000000000000000000000000000000027000000014100000000000000000940000000000000000028000000000000000000000
SP22Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;hofstadii00000000016800000000000000000000148000000000000000000000000000000000000000007500900000000080000000000000650000000000000000000010700000000000000810000000000061000002020000000000000000000000350108003000000000000000000000000000000000000000006100002300000000202000001000000000000000000000073011505300000066041200028100000270000000003000130000000000000035100000000000000000000000041000000000000015800000000082000000000000409000000011492076010000000000000025000000000000000000000000000006900000480070000002470000000000000002244200000000000006700000000000001700000000000000000001950000009900000000000004101400000000431600000000017600000000000000000000000099000230000850000107000088000000000000000000074000830000000000000000770000011100000000017200000000000000000000204000000
SP220Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT4170000007000004400000000000000000000000510018500000000360000066000018400000000000000000009100000008900000000000000211000000000000000000000000000000029830000004500000000006300000000000000000000000000071000002920010380011000000710910000000000000000000000000000000190000000013100171000000000001180000000000000680000000000000000000000000000000000000000048700000000000002803800000002093080000032700000000000000000000000000000000000971391890000000005620000037102660000000000017200000000000940000001260000010705630000000000000000000000105000000000000000000000000004900005000001960079056000000245068000000000000046000000237000000000006100007073800640530000000000000000000000008400000000000048300529400000410000001520027021000000000003809500001500000000022000000000060000000000080014400258210430659003360332246
SP221Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;baroniae0270000000000000000000000000000000000000000000000000000000000000000000000000000500000000000000000000027800000000018000000000940085105000000000008000000000750000000000000000000372020004500000000000000000000000000000000000000000370000000000520000000026200000000000000001970000203000000001080000000000000000000000000000000000000000185000000001460000000000000000000000000002300000000000000000242000000800000000000000000000000000000000000000000000000000000188000000011400000000000000000000170000000000000000000051000000000000290000000000000000002808100000000000000000001230000000620000000007200005900000000000000000000000000000000000000000380157250000021000000000000000000000000000000000000000000000000000000000000136000000000070096066690006200055115
SP222Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT23000000000000500000000000000000000022840000000000000000000000022000000000000000000000000000000000000000006900000000000000000000000000000000000000000000000000000000000000000640000000000000000000000008600000000000000000000000000000000000000000000000430520000000000000000000031000990000000000000000000000016307900000000000000000000000000000000000000000000000000000000000000000360000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000290000000000000000000390000000000004900003300000490000000000000000000000003000000000076000000000000000000000000000009500000000000480000000000015700000000590000000000030000000000000000000000000000000000000006583000000000000055
SP223Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT5260000000005600002100000000000000000000000150000000000000000000000000000000830003800000000000000003300000000044000000000000000000000000000000000000000000090000024003900000000000013500000000000001430000000000000001290000000000000001210000000000000000000000000000000000000000011700000000000000000000000000000000000000000000000000000000000000000000000114000000000000000000000000000000000000000000000000000000001170000000000000000000000000000000000000000000000000000000000000000000010900000000000000000000000000000000000000000000000000007300000000000000005100000000000000000000005600012500350000000000000000000000000000000000186089006700068000000000000000000000000000000000000021000000000000000000000000000000000000048000065000750
SP224Bacteria;Fusobacteria;Fusobacteria;Fusobacteria_[O];Fusobacteria_[F];Fusobacteria_[G-1];sp._Oral_Taxon_A71000000000133000000410000000000000000000000000010846000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000920000000000000000000000000000000002980000000000000760000000000000000000000000000000000000000000000000000000000000000000000000000000000000011900000000000000000000000000000000000000000000080000000000000000000000000000000000000000000000000000000000470000000000000000000000000000000000000000000000000000000000000000000000000000000001010000530000000000000000000000000000000000000000000000000000000000000000000000000000000000006300000
SP225Bacteria;Absconditabacteria_(SR1);Absconditabacteria_(SR1)_[C-1];Absconditabacteria_(SR1)_[O-1];Absconditabacteria_(SR1)_[F-1];Absconditabacteria_(SR1)_[G-1];bacterium HMT3450000000000052031000000000000031007300000007700000000000000000000000000000019000000000000000028000000000000000000000000000000000004700000000000120000000003000000000023000000023020790000000000900000000000000000000000000000000005000000000000000000000000000000000011900136000000000000000000000000001840000000006800004700031000000000000000000910000000000000000000000000042011000000770000000115000000000000000000000000029600000000000005000091000000000560000000126000000460000000001040000000000360000100000000000370190050000005300000000560000000000000000140000540000000000000920000014000000290000000000000000000000000000000000000000000000000077000006000000000000000500000000004101000000000000000000000000000000000000000000260000000006400001230000000026
SP227Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;maltophilum000000000006700000000400000000000310000087000190000000000000009400000000210000001700000000002200000450000000010880000000005600000000097006659000000000620320000000042000000000000000000075790010000000000280005500000000500000000000000000000151000002200010000000000670000000000000000173000000000000000064000000000000000000000000680000005700000000000000066000000001700000000000000000000000000000000008412600000000000000000000000770000000000000000000000000003800000000000000000000165000003100000000000000000000000000000000000230001200230410001700000000034009900000072003700460000910007200603400000400000640000016045000740000000000000000000012000000350000000000010607000000400000000000000000000046004700000000000010700000000270480000000210003200000000000029000000008201072
SP228Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Kingella;denitrificans0000000000000000000000260000000000100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164000000000000000000005600000000000000000000000000000000000043009000000000000000000000000000000000000000000000000000000000000000000000035500000000000000042000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008700000000000000000000000000000000000000000000000000000000000000000000003100000000000000000000000000000000000000000000000000000000000006000000075000000000000000000000000000000000000000000000000000000000000000000000000
SP229Bacteria;Firmicutes;Mollicutes;Mollicutes_[O-1];Mollicutes_[F-1];Mollicutes_[G-1];bacterium HMT50400000610002400000000000000000000000000000000000000000000003800000000000000000000000000000000000000000007700000000000000000000000000000000000000000105000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005500000000000000000000000000000000000000000000000001820000000000000000000000000071000000000000000000000000000000000000000000000000000000000026800000000000000000000000000000000000000000000000000271000000000000950000000000000000000000012400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SP23Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT126000006700000000000000000000000000004200000000000000000000000084000000000000000000000000000000000000045013000000000000000000000000000000000043000000000000000000000000000000000000000000000000000000000730000000000000000000000000000000000011001800000000000000000000000000000000000000000000000000000000000000000000000000000000000165000000000000000000000000000000000000000035097000000000000000000000000000000000000000000000000000000000000000003400000000000000000000000000000000000000000000000000000000000000000000041003700000000000000000000000000000000000000000000000000000000000000000000000000032000000000000000000005202800000000000000000000000000000000000000000000000240000000000000000000000000000000000000
SP230Bacteria;Firmicutes;Clostridia;Clostridiales;Peptococcaceae;Peptococcus;sp. HMT16700000000003195800000000000019000000000001800000003400000000000000000000000000000000000000000000000940000000000000000012800000000000193392900010900000000140000000000000000000000008353000000000000000000054000000000000000000000000000099000006400000000000009200000690173000000052000000880000000000000000000000000000000000000530000008400000000001390000200000000000102000000000000010500000067000000000074000058026100000000000000000000000000000000000001230000000000000001400000000000000000000000000003360000000000000000000970000025000350000130002160000000690000024004100000000200360013800000000000000000077000000000000000000000000000000000000000000000000041000000640000000000820000000000000000000000073000000000000000000000003600000000000001100430003100000000
SP231Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT9140000000000000000000000000000000000000000000000000000030000000061000000058000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008500000150000000000000000000000000000000000000000000000000001860000000000000000000160002100000000660000000000000000010800000000000000000000000000000000000000000000000000022900000003070000000001160000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004200000048000000750000000109000000000000000000000000000000000000000000000000000000031000000000000054000000000000000000000000000000000000000000000000000000000000000000000000000000000000138
SP232Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT2680000000000000000000041700000030000000000000000000000000000000000000000000000000000000000000000000000000000000004400000000510000000000000011000000340000000000000000000000000000000004300000000000000000000000000000000000000000000000002500000000000160510000700000000000000000000000000000003400000000000005606000000000000000000000000000000000000130000000450000000730000011100000014000720020473000000000000000000000000000000000000000008000000000000016000026000600000000000000000121000000000000370000000000000000000320270000000080027000000000000003600320000000000007500314702400000000009058000000000000000000000000008000000000000000011000003002400000000031018000011032000000000000000000000000000380000000000086080000000000000000000000180410
SP233Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;pleuritidis000001400722287008438690000000099000000013463000000000011280126042001418300025200013000281907900018187000000000000806400028101270000086000000000381140095710439749900165340000001980000005200928587000970000063000170055000015000077390000000120000000079000000000063031301430000000000000372000011400008015937105000005400000002941110070465900340930000024601640390000316140000000151205000021900000000003313117018200000036806680202000001730001794410000059960590367112103145500000279006726100187017500289001960000000006240011621801831334630563110252000054916800000940000000001731439718800111222131000115263062000010040099000179014910400000002656660000000182000000073225327096669000081012450041550028303000430002794863552000950660000005000009998000940076000000100031813500098000000031500670000001260000008300000001540000000000098483053990000000102000800009186000870010400000071001492410138000000960025100740630000010600158024758000000046080868043009900137980322900007008800001565173003600000
SP234Bacteria;Firmicutes;Clostridia;Eubacteriales;Peptostreptococcaceae;Filifactor;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
SP235Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;pallens00000000000000000000039000000007027000000010200000000000000000000000000000000000000000000029000000000000000142000000000000000000000930000000000000000280000000000000180000000000000000000000510000000025000000000400000000000000000380000000000000000001520410000000000000000000257000000000000000000000000000000000000000000000000000016600000000001330000075000000000000000000000000000000000000000000000000000000022703951275007300000292044001401460000000000012603530000000000000000000000000000000000000000000000000000000007000032000000000000003984000034003900450000000410000000000000000000000215485000000000000000000000000000700000000000000001060000000000960002800025000000000000000000017000000001300000000000000000000000000115000000001500000104005503700700000074
SP236Bacteria;Firmicutes;Clostridia;Clostridiales;Peptococcaceae;Peptococcus;sp. HMT16800000000000000000000000000000000020500084000000000000000000000000000000000000000000000000000000000000000000000024000000000000000000000000470940007000000000000000105000000000000000000000008000000000000000000000000000000000002000000000000000000000000000000120000000000000000000000000000000000000000000000103000000000000000000000000000000001240000000000000000000000000052000000091000000000000000000000000000000000075000000000000000008500000000000000000000369000000000000000000000000000000017240000310000000000000000000000000008802300000000370060000000520000025000000440000000000000000000000000000000000000000000000000000003200000000115300000000000000000000000000000000000000000000000000000000000000000000000000829100000000165
SP237Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;sp. HMT044000000000000000000000000002500000000000930000000000071000002728000000000000000000000000000000000610000000000000000057061000000000057420000000000000000082000002905300000000000000000000000000004958000000000000000000000000000000042000000000023000000000000000000000000000000146000000000000180000000000000000000000000000000000000000000000539500000000000133000000000000000000000000000000000000000000000000000000001790000310000000000004470016700001400000000000000860000000000000000000000000012401340000000000003400805700001315300814400000000000000000000003800139000674400000000000000000000000000000000000000000000000000000000000000000000000037000107000000400000000000001436000000000000000000000000000000000000000000000000000000000000000380000107000720
SP238Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT278000000000000000000000052000000000000000000000000000000000000002000005000000000000000000000000000000000000000000000000000000000000000000021410000044000000000000026000000000000000000003342000000000000000000000000000000000000000000000000065000000000000078000000000000000000000000001090000000000000000000000000000000000000000000000002310000186000000000000000000000000001230000141000420000000000000000000000008801820000016300000760000010700000000000000000000000000000000000000000000000000000000000015150000000000000000015000000000022000062000000000000001010000064000000000005649000000000000000000000000000000000000000000000000007908500000000000518300000000000000000024000000000000000000000000000000000000000000000000002000000320440000037
SP239Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT1490420000000000000000000000000000000000000450000000000000000000000004800000000000000000000000000000008400007000000000000000000000000000000000000000099027000000000000000000000000033720000000000000000000000000000000000000000000025000000000000000000000000000001500000000000000000000000007900000000000380000000000000000000000000000000000000000000000042000000000000000000000000000000008700000000000000004200000007800000000580000000000000000000000000000003300004200000000000000000000000000000000000000000000561100000006500000000000001120000000000000360002101060003000000036000000000000000000000000000000000000000000000000000000000000800000000000003000053000000000000000000000000000000000000000610000000000000000000000000000000
SP24Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Corynebacteriaceae;Corynebacterium;matruchotii00036010393067155601310150601312717326924002672811869093026730482731451500497042776916620407800238046714214900094000413262116012611584745131422800731525091090352622565322473105001408260477000003200000590502640042139560231501051868491150003177678023317519467449528916517604800020216000018602167271980005030209108001916124100386001340134578856341170365652243010702334059304751110688033311955152445010520560176581354677212102520347191235900084127800000343009024702183320018502900000184001253200001560101253001130000000175352000128705440001472582479141282009335500000007600268607017305721019701490000319012840001861750000000231000532003955230001741520254940126003710000002212520000056002820273575013300713270047209010150655130000000000155002373530192062213118500037902030135300300114016429981940279000029900001927660000125203612814015500002018000003075261148245140033802520910056600000163044471171000264216860071272160001432220180010070706320210345040010105811471226117340116029252115184048501631146182836823000215007400642981020010115519513842583069101539873543041627311188257160201766800344392619447319700305167866389402555745509200415010332110705031633301530366855261817560165195481010410500244102965732791013797439021991303710029123765037014210964584415240000981353226821134048302702491195590080803623560989820059320307604506370147344127050340246017258005766301953208200044120772412143511492000
SP240Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;flavescens|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
SP241Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Schaalia;sp. HMT1800000000000001180000000074000000000000000000000000000002900034000000006700000000000000000000000000000000000242100000000000000000006300089000000380000000520000000000039000000000000000000000000000000000000000000000000000000270000000000000000000000200217000000000000000000000000000000000000000000000000000000000000000000000165000000000000000000740000000000000011000000571000000000000000000000000000000000000121000000000000000000000001670000000000007800000000000000000000000690249000000000000000000000000000000000000000000014014500000000000000000000000000000000000000000000000000000000065000000000000000000000900000006200000630000000000000000000000000000000000000000112000000000000000000000000000000076003900300000000113000000000480
SP242Bacteria;Proteobacteria;Gammaproteobacteria;Cardiobacteriales;Cardiobacteriaceae;Cardiobacterium;hominis0000000006000000000850006797670000084210000001160000000003400000000000000000000008900000000000086000000004400000000000001900057000000280046004400750000005800000003700000000420000000000000008500000000008200000000095000000001201120159000000000000537600043008600000000000032700000000005301291370184000408000006800092113000001501261221610000000002451200000000012800000000000000000011200401190000000000000000000017600000000019900000000000221000000000000000000000016157137000031000000000000000048000000000000001350500000034600000001170000000660222000002684000000040000420840000650835900000000000000119000068000008400610000010500005777056000004200170360000000022469100000005210309100000000000000000030000012410058000613405800000073092152074005126000620002060096239800008693000560001470000037062000006800028000045000350000000117000000000056001200
SP245Bacteria;Proteobacteria;Betaproteobacteria;Burkholderiales;Burkholderiaceae;Lautropia;mirabilis000870000000000004200000757005613003200000500000003130000521690000452250023000350000039017350000018000000000000000000040023000380000142000000500002420062002023570000570000001530000008500000000625850195000006411700005853002001290019208031811302230000840121519250703380200010504090000001300000000000008700007400048510674229200000149097600001470000860028589014700002130904210012800000219000191001270000645001231172246005900000018600000000530034400000000007200000000000000000000000000290132650000001080000000000017700056601520000017000000053300000021911300000000003000069400186000001172000768000000000000000007402510000000016874000190000000680939200000019100002280006610126348044217900002434385602580000366093085000000000000145080000784160004330440821300149382008900008716500000073000060000011800213007429870037108033323838501800107000492134400405002480000019045023100046471300000991020600011110039000000800000012004400781200000001039667004710052007100032800432803051030
SP246Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sobrinus0000000000000000000000000000000022400000000000000000000000001250000000000000000014600000000000000163000000116000017200000000000000000000000000000000000000000000000000000000000000000000000001500000480000000000000000008100000000000000000159800000000000000000000000000000000000003560000000000000000000000003580000049300000000000000000413000000068900000000000000000000000000000000145000000100000798000000000000000000000000000000000000000000001830000000000000000000000000000000000000000000000000000580000000088000000006500000000000000000000000000000000000000000000000000000000380000000000000000000000000000000001080000000000000000000000000000000000000000000000000000000000000037000000000026400000034700000000000000000000000000000000000
SP248Bacteria;Spirochaetes;Spirochaetes;Spirochaetales;Spirochaetaceae;Treponema;sp._ovinefootrot00000580000011000000000000000260000000000015000000000000000061000000000360000000000000000000000000000000000340000000820000000000000000000000000160000144000000000000000051000000069000000000000003500000000000000000000000000000000000000000000000000000000000000041000000000000000000000000018900000000000000000000000000013200000000000000013200000006700000000000000250000000000000000000000000000000000000000000008900000008600000001190105000000048000000011300000000000000330000000000000078000000000000000044460000000000001500000000000000019000006200000000000826600001500000000000000000000000000000000000000000000000000000000000000000000109032000000004100000000000030000000000000000000230000000000000000000000000000000000000000600000000000138
SP249Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;oris57153002950000200006800000653002290013000000283000227111506005101713790000640020600001400200112004780940332320001030000000370172133000000000462150000071000750006460197008718822129052700165002280485800000001068000015200661000001640000010980002330143827000221490000944111000000015000295000000035820622474500420893300371000000022200002936181023701680011900089001520000000000308100000000070000001640000470000194000001572000082370000008800000002380186326380010440079200027908304070000000000460000000830222000000000000000280000004400000011424029506100000000025500000000000000000522698079100002483800221002710000000000015000005000000004400020709400000002442430290101003670920115000000000000000107909001831138720001810856110172650015703680002651730000010500004420407922320058021301780316200000000084000071025002401613012400025400023100018190000016515047017573006860000040957001062635821032221131000310916300001930000341000240000339406400000043800240000147000000002521190000000244002414630267185000021400004010090151456800
SP250Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium HMT132070000000760470000000000340000000000000000000000021000000000000000000014300000005204103400000000000110000110000338000000000000000000019300000000000360045000001700000281310600000000000000001300000000000000000000000000000000000050000000031000000142000000000001860000000052830007100001019000000003410000000350556000000000000000000000052700000000930000000131000000000000000000001009381000000000000000013000199000600000000000000000000291860000000000000000000000000072000151000000000077000000039300027300306000000000000036000000000000550038000000000000000000690001800000000082240007700000000000000000000006500004800040068002100000000490004500000000000004246000000000000002500015010306200000000000008700000900000000049000000000000160000000000000180000000003800000000000007553700000000
SP251Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT513000000000000051000000001110000000000330000000000000000000000012400000000900000000000000000000000000000000000000000353000000000000000000640000043116148000000000000000000059000000000000000000000000000000000001460000000000000000000000000005200000000000000000000000000000000000000000000077141000000001379000000000000001210000392000000000000000000000000001442500000000000000000000000000000006400000000000000000000000000000000000000033600015500317000000000040200000002810000021000000000066000000000000000000000000000000000000000000000000000000032000000008700000000000000000000000450000000000000000000000000000000000000000000000000000000000003580000000000141000000940000000000000000000000000000000000000000077000000000000000000000000550071000000045
SP252Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;dianae0000011200167000000091000000000000003101090000350000000000000000000000000051750000032000000000000000000260000051000000000000000000000000060000000000001300025312902900006300000028000000000000027000410000000000000000000000000000000000000000000000000000000000181000000000000000000000000000000000000000000022910300000000000000000000009000000000000000000000000000005101740000033700034500000000000000000308000000000740000000000000000005900000000006000000000103001090000000505000000048100000000000000000000000000000000038003200040075000463500000000000000000000000000000005700000430000100000000740000000000000000000000000000000000000000000000000000000003157000015001300000380000006200000011600240000000000000000000000000000005000000001210000000000000273200009900130000077
SP253Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT48100000000000058000000000000000000002400000000000000000004200000001100003000001600000000000000000220000000000036000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000910000000000000000000000000000000000004000003600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000340002400000000000000000000000000000000000000000006600000000000000000000000029000000000000000000000000000000000000140000000000040025000000000160000000000000000000000000000000001600000000000000000000000000002700055000004600000000360024000000000000000310000000000000000000003300000003000000000000000610400160000000000
SP254Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-3];bacterium HMT5030000000000061000000000000000000001929000000000000000002900000140000000000032000000000000000000000000000000000000000001400000000006100007900000000000131013007500000000000000000470000000000000000000000000000000028000000000000000790000000000000000000000000001100000000273000080000000008700000015300000000000000000007201050000000000000000000089000000000000610000000000000000000059000000000000000000000000000000000000000053750000000002301620078000000000000004700000001920000000000000000000000002500000000000000064000000000000000000000000000770000080086000000000000000000000000000000000000000000046000000000000000000000000000000000760004700000001877190000000000000000000000000000000000905700000000000000000000000000000000078000000001130860210
SP255Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT33500000830000000000700000000000000000000000000000000000000000000000006200000000000000000000000000000000000000000008400000000000000000000047000000000000000000011000000000780000000000000000151000000000000000000000000000000000000000132000000063001710000000000000000000000001700540000000570001240000000830000001710000000000000000000000000000003500000000000000000000000000000000000000000067000000000000000000000015300000115000000000000018400000136000000092000000000002100000000000000002190000000000000000000000000000000000000000000000000000000000000000000000000000280000000000000000000000000000000000000600000000140000000000000000000000000000000000000047000000070000000000000690000000000000000420000000000000000000000000000000000000
SP256Bacteria;Firmicutes;Bacilli;Lactobacillales;Aerococcaceae;Abiotrophia;defectiva000345000000000000000000600000040001702100000000000002400000560001630000000095000000000000000078000456100000087106000007800000940000000000118003130310000000000000000000000000002201630000000000000000000208550000000000077000100039000000000000000000000000000000000000004920000000017000001290000000000000001620154000000070900000000000245000007200000000000000021001690000000000001680000000000000000000040600000000000000000000000000000052800000000000170000000000000000000000000000000000000000000000000000015900000000000000000000097000000000117000000000004200795306012500000000000067000000000000000000000115000000150000000131000000000000000000000000990000000140003800000000338000000000025000000000000000035002196000000012818001706100000000000000000015100000000000103000000007800000000000
SP259Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. 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
SP26Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;johnsonii00000000000000000000001580006400058600270000012200000000000000460000000035500000000003710000000387000000000000000000000000000000000000000000000001200000000000000000000001500000000000000000520000008827700000000140056000000000000000000970000000000000000000000740000000000000000000000000000000000000005200000000000000491070000000000000000000000000000001470000000000430000000000030000000000000000000000000000000000000000000049911200000000000000000000000000000000000000000000037000235000530000000000000000000000000000000000000304000000000000022400000000001670000000067000000100000002170000004800000000002800000000000000000390000000000000054000128425234006386200000000000217000000000000000000100000002650000072000000000000000000029100000055000000000776736000109133400000000017928
SP260Bacteria;Actinobacteria;Actinomycetia;Propionibacteriales;Propionibacteriaceae;Arachnia;propionica086026006407900031000000000156000974300000000025011000000000000001520001080001480001501160000206000008900000082044000000001492000057047000000006452000870296003402230000750009701760000180000000032600004000000007300000027006301420001020001170000001000129000000000000000000000002790000000000051000182112189000000001160160000097000125013845000049013901390011808000022600000000150740000204173000126000000000000000015001380000000251260000000000000001620000580000000044200125003100000000000000001360000000170007400001320000000000005680000000000004139000008601920000029100000000000126000108015400000102000000025112200099700000000000000084000000480190001550000612519500000016400000024990001200775310000120088006900000348000000000059000031000000021000005000111014688600076000000177160200113000000029209954012010002270099001110007000000001470000000000000096059000000000000000644600000116460103006300000
SP262Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._Oral_Taxon_1801251071723801140000000122001400123002110010208160380001760163430000000000088019729193000000324001272551005011000118410350831300000000000039701160138000000000243002099900000941494024530900300133780012490000001540000068001700000164012901300000080000015100239000205331000018815300016200010600195000002351263761024301501370000000001120000000000000000015306980033160000000000000000023300003310000001880000001340000000010917900000000000000021400057600023612400000000057300203000000279004230000000000000013190005240000000000000000000004880031900000007281376002390980000000078000000001070000000014500172000000010900002650000031200953000001921130000000248069101000370000000000000000114001130003101075951922695828400017000109002140930267586261460266084570100197000095000135000761610000011690006280538303203170070467000000000000000187008245000194000000000001430043149426600015400000001020274040541825611939700049000880007713801500123342000002600038066000620000075007610723900477120000000820002925013829812100
SP263Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT91900000000000000000000000000000000004700000000000000000000000082000004900000000000000000000000000000000000000000000000000000000000000000009200000000000000000000000000000000002149000000000000000000000064000000000000000000000000000006000000000000000000100000000000000000000000000000000000000000000000000000000000000000000000000002330000000000000000000000006500000000000000000000000000003580000000000000000044000000000000000000050000000000000000012200000000000000000000000000000000000000000000000000000000000000000000000042000000000000002000004000041004729000000000000000000000000000000000000000000000000000000000000800000000420000000000040000000000000000000000000000000000000033000000000000430000000006000000000000000
SP264Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-5];bacterium HMT511000003000030005700000026310000000000000000021000000000000000000000000005200000000000000000078000069890000000000000000000000000000000000000123000006600016125000000000000000000000001701310003100000000000560000000000000000000000000000019202800000000000000000630000001772120000004122196000373041000000000037000016605400164000000000008705824877000001640630000000162001540000000000000000000000000000000186000000176000600001990000089000000000000000000000012300066000010900262470000000000000000000001150004400000103000000000000000000000000000000970000580000000000000380000420000210009706403900000044086000107000048000147000078000037000000000000000000000000000000048000000000000002100018087000519706300000000000000000000000000360010200000086125000000000000000179008100000000000000000617963330000000000000
SP265Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Mogibacterium;neglectum0000000000000000023000000620310000000160000750000038000000000000014300840000000000007806500014200000000000000000000002800000000003901110000000000000007500400000000001740000000000015000032000077910000000680000025011000000113000000000000770074000000025560000000000000003740000000000000740000115000000103000620000000000063000000000000000000011381006000000000000000012300000000000000000000000000000000000155000020800022006301411460162024100000000002040000000000000000000000000000000039610000000000000000000000013900000019306200000000405600008157000046000820005800614200000112013400000000003810901300000000000044004400000930250000043000007002400000000000320005100028000000000008200053004000011200000770044000000260007500015090000000003006000000000004400000000006900000350001069003000012000000000000000000
SP266Bacteria;Firmicutes;Clostridia;Clostridiales;Peptoniphilaceae;Parvimonas;sp. HMT11000000044000000000000000081000000000000002000000000000000000000000000000000000033000000000000000000000000000000000150130040000000000000000000060031020000460000000000000000000000000000000009900060000000000940000000303000000000540000000000000000000000000000000000067128000005200000006000000000000000004000000000000005515700000000000000000000000097000000179000007130000000000000000000000000000000000000278000000000000002430000000013200000000000001000000006300000000000000016601970001900000000001590000000700000000000000000000000000000000000760000018060005010000006200000000000000000001487017000000000000800000000000000000000000000000000000000006001700164000250000000000000000000000500000000000002600160000000000000000000000000000000000013001770051000430
SP267Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Mitsuokella;sp._Oral_Taxon_G680000000000000000000111062000000000000000000000000000000000000104000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007600009100000000000000000026000000000000000000000000000000000000000000000000000000000470000000000000000009100000000000000133000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024600000000000000000000000000000000000000000000000000000000000000000000000000000008500013100000000046000000000000000000007400000000000000000000000000000000000000000000000000000000000000000950000000000000000008200000000000000000000000000000000000000000000000000000000000000000000000
SP268Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;endodontalis000730000034000000000260000001907502801014600000000000000000004400057000134000000000106000001020000960401130000005600000000000124000009400001630151000000027103000000000000000000004100000200000000890810000000001960150102000032000013200000000650000630000760000000000610110830000000000006032430000000000000000000181330001380006528300368930011803480003340000000450000000680000000001320001791200000127158108056040000007700000000910192011100000950255000024800075003851890001090106072007901520000000166019600000071000000129002381070000000000000000046000049000319022800011760228010800209650000277000000369000012101671000000077000580079600000001580000001271217000000000000000000251000000471120000440121031075001577800008505800890084188000009301605800000000097000000001561326600805900003704346000046800006900000001431360036406100018762620019517411700390000000000000656701235100001739200211000000328300000000000420000
SP269Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT338000000000000000370000000000000000240000000000004500000000002400008000300000000000000000000610000000000000000000000000000034000043007300005300000000000000000000000002100000000000000470000000000000000000000000660000000003900000000000080000000000000000000000000000001450000001750000000000003300000000062000000000000000000000000000000000000000002700018000004400048000000140000000000000000043000000012113700000000000000083990000000000000000000000000000000000000000390014600000000000000000360000000000000000720000000000000000051100025000005400470000007700000000000000000001900027008100000000000000000000000000000560270000002100000000000380000045000200000000000000000000000000000000000005203300001010000000000022000000000008905200002300730000004900000000
SP27Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;tannerae06012400182024116711804342880011858000012003200768161238008687112018155001130880115000000000001130000000365099000001431000153080001420000107080008700000800152096500181285408401040000000911020571060000000501352224105000411165876013700004106856000105000098046531610021983060077000573701050000000000000000424098092105660150000000520000880001172630000036105358671000001721913080012714125600932812006100002330356172196244610339017741314144900760633650195007938504160133064923611001220045753218020416925000020801680018913911500000682114606220067800809155000521681482280026902260000420010556000003010265020818407900030511446935300004672910243285006640000021002503090147077342640044400536737006726101150710371866197036855185932130366000026128295039800000236360720000283000651230750020261617350156187000120001330006121910700013701601500060010750114001040011611303489017801615009700078493299376103954058096158105526600000062003205200127000910098370020703200000790000000003300000210100820012802073311208614553500350013155015500560850001600120055200006201130021360001220980104000009253311080000007821315400121002900002470260101132139147151580142010707287
SP270Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Megasphaera;sp. HMT123000006800000000000000000000000000000010500000026000000000000000000000000000000000094000000000000000000000000000000000000000000000000000000000000000004900000000000000000000000055000000000000000000000420000027000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004100000052000000000000000000000000000000000000000000002300000000000000000000000000006500000000000000000000000000000150000000000000000000000000000000000000000000000000000000000005400000000000000000000000000000000000000115000000000000000000000000000000000000000000000002800000000000000000600000000000000000009600000000280000000000000000000000000000000000000000000000000000190005400000
SP271Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT49800000119750000139000000019687000000000000000000000000000000000000037200000001280000000000000000000314031695000000022300013900000000008700000000000000000000000000019500000000001530087000000000000001037000000277003000000000231001410000000006400000000000000000000000000000000000000000000000000027010730027300000000000000004480000000000066014500000000002550000000000000170015900003620000000000000047000003870000000000000059000000000000000000000000000000000000000039900000000267950000000000000000319000000026802070111000000151000000000000000000000000000000000000000000000000016700000000000370092181900000000000000190000039624000000000121017400000006700000000000000000000000000000000035000000520049000000800000004600000027600000000000142000000000000000000460003900000000000000170000000084001020120116
SP272Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT414000000004800050200000868000000004002280000000002020000014300490000000000000000000000000000000000000056201060034001040000492001610000000000000000000045100000102007733603020000000000000000808800000038000000126000000000000076005600000000000000018100000000000000000000000000000224600000000000000000000000780000000038200000000000000000004640000000000000000000000000000000000000000000000000000000001750000000233000000028490000000000000000000000000000000000000002390000000004100214000000015900000000000104700000000000000000000000000460000790000480000000000000000000000009400000000095005600000183000008201460000193000000000000000004100000000000000000000000000000000000003600668000000000000000000660433000000000010740000000000000000000000000000000031500000000000000000000000000000500056564
SP275Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT47200000000000000000000000000000000000000000000000000000000000000000000000270000000000440000000000002870000000000000000000000000000000000008600000000000000000000158000000000000000000000000000000000000000000000000000000000000000000000000000016200000000000000000000140910130000000000000000002240000000000000000000000000000000000000000000000000459000011700000000000001810000000000000000000000000000000000000000197000000000820000000000000000000000000000000000000000000000000000000008600000000000000008100000000010700000000000000000000001880000000000000000000000013200000000000000000000000000000000000000000000000000000000000840000000000000000000000000000000000510000000000006500000000000000000000000000000000000000003900000000
SP276Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium HMT14500000680000000000000000000000000000000000000000000000000000000230000000255000000000000000000000000000460000000000000000000000000000000000000000000000000000025000000000000000000000000000000000000000000043000000000000000114000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001420000009800000000000000000000000000000000000000000000000000000000000000000000000000459000000001300000000000000000000000000000000000000000000000007000000000000000000000000004400000000000000000000000000000000000000000000000000000000000000000000000000119000000000000000000000000000000000090000000000001700000000000000000000000000000000000001920000000000000000000000000000000000270000000000000
SP277Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Schaalia;cardiffensis000000000000000000000000000000000000000000073000000000000000000000000000000000000000000330000000000000000000000000000000000000000000000000000000000000000000170000000000000000000000000000000000000000000000000000000000000000000000000000000000610000000000000000000000000000000143000000000000000000000000000000000000000000000029200000000000000000000000000096000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071000000000000490000002600000000000000000005000000000000000000000000000000000000000000000000006200000000000000000000000000000010460007106100000000000000000000000000000000000000000000000000000610000000009800057000000000000004707600000000
SP278Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Shuttleworthia;satelles55105000380000028490000033001890041000000031000006300002500000000000118000790000000000000230004600050000041000000000000000000000000000000000000000000175015301630000050000000000000002600012500003505600390000000378406000000169000000000000082079007600000000000540000000000000000000000000000000022300000000000000000000372000008400000000000000000012200000000000000000000000000000601220044100000000000000000000000003753980000000000000000032804330284000990000640000000970000130000000000000000680200004540000820000003770000000062000000000000001200059067000000000421400000460030000004800000013600000000009000000003601330000216054000000000000000200000360000000540580012276000000000000007600000000113000000009400000000010601859067001200000330780000000490006100000000000000000000001960000000000000000000003508900000
SP279Bacteria;Firmicutes;Erysipelotrichi;Erysipelotrichales;Erysipelotrichaceae;Solobacterium;moorei30303400260017000313100260372100005900880058450204000000000095000000000063000510680002700001700000190720040030007600002900476004456062002900078000009100010900000000052800160850000000000000000000010800160000000000000000004312500006000000000000000056000000000000000004300000000000000000163113000041004902480000000005202081310268000000000099000000000115948000000980000000000000000000014802207300002750621410890002590260270000001810000001120088950000000051000343700821132700002360001570000000041004732400000000003103000054000014800131000001890000091860032252000012400000007200000000000005900000001000000000027052551577013001130084418400014000534803400221460005300025627101271119000610084203801600000000000000000094005900000010000580006019000000350000314900036500530496013061055730000059001945220000780000000009000056061050000005704690016000767202900000000138000054033003492420000103
SP28Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Dialister;invisus2701880007701680661671281581727010922076092000196012600000030937707628387013200175001760228404107601033860036002230615100012321001200002631450010000110023707400139000002910563160001510001851200431552010000136000003100247580114022387000741090000194012100117102000290480330012149133083265296113580420460551011185700000841409400001401470204074085106010600000006200023500075020442006608821809600691385002570153088256000058770300000155025924474394407132455016219918910326664054601530094388212552080026500000397411130000061712600019002520237007862812100106388067849700218038608721894901510096000169005570004290017302243625000321716332125936921115600341741340109101780000296341013717807706670126009822192021200028936002171403150256000074345000045503055880069606081160188132208022524228900990036201982961140184222047042200002133709746131812200234033500000019001021510551617568221013944000080003241400031601291522761072201260123822875602290185870930321941311431150161011685306000800036211100153000000014000121126245079211002760261355193400000345000233017149000152160380964615504603093332219800007406501021370102379141230020123840431200023914640600530030007969890378987227000000022524470000000142831921151352493000000750095020921066979001140005399
SP281Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT4750000000000000000000000001430000000000000000000000000000000000000000000000000000000000000000000000000036000000000000000000000001900000000001730000000002500000000000000000400000000000380510000000000001700000000000000000000000000000000000000000222700000000087000000000000236000000000000000012600000000000000000000005700000000000000000000000000000000000000000000000780000000000000000000000000000000000000000000000092000005600000000000000000000000004500000000126000000000000000000000000000000000000000000000220000000000000000000002180000000000000000000000000000002200000000001000000000000000000000000220000000000000000000000000000000000000000000000000075000000000000000000000000000000000000000000000000000000000000000000
SP283Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Colibacter;massiliensis000000000000122000870000640000053001100000006400000000000000001700000000000000030000000000000000099001210000000000001120000000000000000000000000000041000660000000001201050000000000000068000260000000000000000000000000000033000000000000000000000000115000000000000000000005360028469000000000000000000000000001070000001620000000000370000000000000000000170000000000010600000000193870000000000260008300000019109400000000000000000550000000000000000080590000001430001380000000000293034300001390016700000000000014300000000000000002510000000000000000000000000650000000000005505500099000000000000000000039000006500000000000047000000080000000000000000000000000000000000001193400008700000000087056000000037000000000010100000000000000000000000000000000000000000000145000920000000
SP286Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;dentalis000004961581090478141002670000016142032701320003670000153000021549435901590001240248012400000000469000000405000187000321100083000000000180058500023402030027443700695703024300000001350000092902590053604201660000148165928608301526231770045400000001330653022302510004320737500023210311370850005941972751780002640274597000013900019201620279021029300000000041000006211906000034101440000000000015200007951910000000000000000081146000004340000000000000426000000014600000025430700001885226000003270000000000000416001194172000000000000000000000000002250478000000000137000000000000007520000000000307000003280059600000000000000000050800031100000000000432000000000000000000590049600000017502700000125008825700743390099049700147990089806601232106921626115730618600003161885062400290000155435521740108260520024400261107077012024303667080002370003470012977002590000004790002240268004860144000000002481630843163547001351234690032300000162080269610069501711203590058101412150005127900034000013000000000530141499000000629330700000000000074600004312040261613891670357390
SP287Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Anaeroglobus;geminatus4014710000000000101000006301501090000000000000364212320039069460000000000000000000086000000080000000000000800150000000000622020043060000121000000000017400000000145001610780000000000000002701290014400063006600067000000000000280007900000006300310000059011963000000000580000000001521610000103000005100011133029200000000130000000002640110000000001022390000000010700000001950000000003450261000000053900000000000000930010100096000000053008700013000001460000208465343815000218012026100000000000265022200113000008358000000000004100024000028100002830021902762980901930155099000166000014300104000000000000034004500860051010600000000980000558311117603000000000000000014600000000000043007600001430114000000074035000023851000000147000134002431000092000000000000000000000000363500145015000110270251400600069133000071038000065000007600000000580002100000000792211200000008365114710440000110073000000000090000097
SP288Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Johnsonella;ignava000000000000000000000000000000000580000000000087000000038000760009300000000000000000000000000000000015700000000000000000000001130000000000000000000000000000000000000000000000000000000000000000000000022000000000000000000000000000000000000000000000000000000000000000000000000000000316000000000000000000000000163000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010100000000000000000000000000000000000000000000000054450000000000000000001320000000000000000000000000000000000
SP29Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT317000002100185014619777980000221106097000001380000046800000000107058000000002000004000000000415000000002677000000090014602581600000007646005491060000000027036200072036502800790000411030000691244800920870000000001661490016400008300249020710200194000880009701320010700000017300000000004700000000000000000011200510000124032518754603610822000006000000002770000152008060014304582780016774801760460072003544683210000000000000865032400000038403400000000185024800000293001980365444179000000000001776632490028605770346027200033100220005977001810033100000029049500000013209516000012370100625067603775630001750076200037903630071513104810011400747040900057741000000241233000291015630526000001260000000000570000924302963848201560000073940005901280189098000007680278770011011600600014967000810000003401043335834000313031000001811680005516600005401820000000000000000000007200213000000000000001390011415000001700011107900001026503127300000000030300208000000212131000000000000000882840698800000146008649000000006802561020000750019809099
SP292Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Eubacterium_[XI][G-7];yurii000000000000043000000000000000000023900000000000680000310000000000000000000000000037000000000000000000040000000000000015400000000015200000000000000000000000000000000000000000000000000000000000127000000000000000000000000000000000000000000000000222000000000040000000000077000000000000000000000000000000001270000000124000000000000000000000000003101210000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000480000000690113000283000000000000000000000000001900000000340230000000000000000450000000000210000000000000000000000100000510045000000012000000132000000000000000000000000000000000000000000000000138000000000006408700000000000160000000000000000000000000000000000000000000000002800099000006100000
SP293Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii59000151151005300036400000008724919700000000000000000000000000035300000328095600009804230000100160840001930193000000000000018800002321170000006700000002410025860017100000332024689116102900000000000011702320523000000000393436031300000014114033300000010800000000000000009912837136613300013700000000017300048400000353000000025500000000014800000295118000230000000000000021302250000000049400000000000003841250000000000009000000000010400000000000003600000000000000000002090000005320000000000000284000000224000000000002230001120770000010600003480000000000000000000005510000003000000000162000000000003632150697100003431340013900088058036300000000840000346002330225014840018501101840292128550000000380001580000005100000002640001400000000000434162103838203030820013300000089966140002100270002531020100012500002897024807291695020000000400001380000000000022100169000023700160000116156000000000300225000078270000161000000017254020572304012620801230500252000
SP294Bacteria;Synergistetes;Synergistia;Synergistales;Synergistaceae;Fretibacterium;sp. HMT3600000000012100971492812500000000800000000004101490930000000590001130004900080000000096000830009700000000000041000000000089035716600000142500390052000630000029500001520000000810008600009500081031000000000000012711600000000000000083000000000000014300000000000000014400000000073000000001621490000002541270000000000001380000000290000000000017500000000000000009702540147790000000086000000000000000570000000001710000000000001760820590000000000308000001460231460000000000000000000000760430000002517700029200009900092000000000000000002890000002150000000000000000000000001560000560000000008500600000000000000006011700023000000000077000030000159000000017000000120006300000000970086035000000000000000230000000000000000852116500350347767000000320046350000000000600090000000000027567400000000000001480000005301590000000075034000100000000107000
SP296Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcus;stomatis0000000010600610037041000000011000000000715800000000000000043009100000005900000000000680000000000390000000000001490690066000000000000006900011526142000000000630750005000000000500000650000001190088630000000001300000000029008400000000000004900000000000001380000188000000006620700000021615627700900000186000000990000001103950001360131410000011572000000025202150122210155000000000001750000000000002590001412482280000001090000000000329000000001640000012623403760033000013800437000000000000186001790112852181742700008100080114039000010116501710000012802110020500000023001830350016900000120000990000180000000600174092376000024109007298000360059010600000000062141000260000006707900001299000019300752000240012000007500000014800670000518300000018700003400000000000000000000019801120092753107500009000000052006400000440067011800000000015406600015500000073016200700113000438200004900000007301070111390107000000041236
SP297Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;sp. HMT203000000000000001031090000000000000085000000000002606700000000000000000012000000000000000000000000000000000000000000000900001798200000017400000000000000000000082000000000000000000000125000031000000000176000000000000000000000000000002450000000000000000000000000000000000000000000000000000000000019315800000000000000000001930000000000000000000000000000000002020000000000006300000000000000000000000370131018600300000001710000000000000000000000000000000000000000000046000000000000000000000000000000112000000000140000860000000000820000000000000000000001350001100000000000000000130000000003100010939000000000900000000000000000016000000000000000000000000006500000000000000000000000000005100000000000004700000000000000000000000000000000000000110005400000
SP3Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;sp. HMT473000000000000011500420000000000000020601090000000000000000001610000000000001130000000000000000000000000000000000000000000440048011500000001711943000000011401518500000000000000000018100000003902600000000000000000000000000275000000000000000000000000000000410000000004598000040700033900000000012700000000000000000000910089180000000000000307000000000000000000000178000000000302840000000000000046000000000000000000000000000104000050700000000000000000002071330000000000530000000000000000038600000000000000000000000000000000000011000000000008700000000000000000000001326100069000000000141000000000004109800000000700000000000360110000000640000000000000000000000020318100000005313400360002202507000000000000000000000030400020450250300000000000000160000000000000000002920000178000153005700000000
SP300Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT26300000000000470000000000000000000000000000000000000000022007857000000000000000000000000000000000000000000000000000000000000000000000000000000000000150000000000000000001500000000000000000000000000000000000000000000000000000000000000000000000000004538000000000000000000000097000000000000000000000000000000000000000000000000089780063000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000056000000000000000680000087000000000000000000000000910000000000000000000000000000000000000002600000430000000300000000000000000000000000000006200000000000000000000000000000000000000007400000000000045
SP301Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT9570022200000260000820000000000457600015000000003800000032040006600250002700000000000000000001300001710000000270000000000000009100000000000021000350000000000080000000016410000000003400000000236700014320292800560590165000000000083000024000920000000000000760000000025000000055201050900000003400000269000048068000007400000601070549500000000000000000000003700005600000000000009300000000000000000000008700000000000003000000000000000000001600001360003800000000000015000023290000000450000000095000001940093000000100000001140000000000196000000008207700550000000044000000068000000000000139000000100081001410000470004800000076000000000000000050000750000000000000000000000000000290000066048000010120000000570000033000000610003900000000000026000000000000280000000000000000000000170003406200000106900007000035160
SP302Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT31500000000000040000000015000260000000007400000000003900000000000400000000660000000290000000000000000080000000118000000000000000000011000027000000000004300000000000000000000000000014053000005000000900000000000240000190000000000000000000000000027000000000000000054000003700000000000000000000000033002300000000000000001040000000000000000000000000000000000049004000000000000000000000000000000000048000007300000052000000000000000000036000000340000001700000000000000044000000000000000000000000200000000046030000000000280000530000000000000000000180036000000029000220000420000081000000002700000000000000011700000000000000000000000000000000052000008000080003000000000000000000000500000004300030000250000000028000000000000015270000000290510000015000000071
SP303Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp. HMT064000000000000000810000000005600000000000000000000284000278000003190003373074000090125000012755045082000371015000000000000870000019100950670109000074001760000000001157600000000000002860620244000000029000000000000062000000000021960000000000000000000000000002430000000000000008706000004020000022100000000001111000000000016100000000060000000004300000389000000073000000000000980003310020000000730062000012551699550041123208020000011302030000000000000000000000002690000000735357000000001056800000692000041002500001900000000680000000000000420185490000000089200000000021000000009201138867201460046300000000270019200018000000011866030450014200000340000479000000001430000000000013656000000000000003750000000000004322328501000077000910323000047181003430000149000000259000107600000000000000000446544219100000730000005250000000005100817905850192003250002010682000001530032200001283000000000000000000
SP304Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT34800084000004100010100011371420008700000044000000000000000000000038000690001800000000000000000000000078000000000000000000000000520000000000000000000006977000000000000000000014000000000000000000000980075000000000350000000000000000000000000000000000000000009600011700000047000000000000000000000520000000119000000000037000000000116000000000022700000000000292000000000000000000001440000000001520000402000000000360000000000000000000000000000470000000019800000000110000000000000001790000660000000000000000010000000000000000000000000000009600000000000000000003600000000000500270000000000000000152430102000001500000004200000000000000000000000000000000005000002902900008700000000000000000390031700000000000000001270000000000000056000000000000000000000530000000780720000
SP305Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-6];bacterium HMT870000000000000000000000000011000000000000000000000000000000000001800000000000000000000000000000000000170000000000000000000000000000000000047000000710000000000000290000000000000000310000000001400000056000077000000000000000000000000000000000000099000000000230000000000000760000000000000000000000000000000000000000000009600000000000000000000000000000000007600000900000010800000000000000000000000000000000000000000175000000009800000000000000000000000000018600000000000108000000000000000000003500000000000000000000089000000000000000000006000000001250000001010000000620000000000000000000000000012000000000000000000000000000006400049000000003800000000000010000000000000400000000000000000000000000000000000000000000000000015000000046
SP306Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT4420000000000000000000000000000000000000000000000000000000000000000000000000000005600000000000000000000710000000790000000000000001500000000000033600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000170000000000000000000000000000000000000000000000000000000000000000111000000000000000000000000000000000000000000000000007500046000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000087000330000000000000000000000000000000000000002620000035000000000000000000000000000000000000000000000000000000000000000000000000730000110000000000
SP308Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT41200000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012000000000000000000000000046028000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000093000000000000000000000000000000000005400000000000000000000000000000000000014100000000000000000000000000000000000000000000000000000000000006802020000000000000000000000000000000000000000510540000000000000000000000000000000760000000000462900000000000000000041000000000000250000000000000000000000000000000000000000000000000000000000000000000000000000040000000290000000000000000300004700000000000000000000000000000000000000000000000000002800000000000
SP31Bacteria;Firmicutes;Clostridia;Clostridiales;Peptoniphilaceae;Parvimonas;micra15212520786016124967451739727375096261080008101360311716671490698129539838113110216150020884620103603760105254741611700003980017736150114079500150012819971164953011917311399220066600270850014958188540332403783524700001243614104413133006900758138059021510095000032812815300047016297091762281653084150080910105101561190128017124182016249831742652829488686957939436200028120816132114241421882000036287400036202391280231741533218310000015001330000137000432217542540005510537000102051164200641178037219023318016692262085273918009527910250375354131620006499706663641101060107413940024600839902970268025677941418682322011614443098270344602310580169001091711459423974129701818435390417715070123159901683475450001479203590880046000102213000001121923311101841020104967607004785763002134363190118283001415603792362130051620405111249211480020464600850124976943999211404250035168000015272515106303943708446313008302129236628750212263045101052340954510475442000215103804924618900675178049887018176154000402683601811626221001681556301442350571852804670053675614519032611408119569503125018010483891728120622531114470701618251938214690130896179486768016904821934041290530131033005103647710691264040912399009780066001525180109010060752291590056010905235213112210164861051325518101765323710002681732365565924502764802122798225481328315378137622916000449000103057258847002260640965205315240719680190188169566215400209125328000001586650223193209110407240056671260176142160
SP310Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;massiliensis0001140064000000000000000004960224000000000000980000000000000000000000000000390001040000000008206700000000000006600000000175000000000000871460121000965501290009900000091000149000000130308000000078202000000000000101770681720000000000000470000000000000051000000000000420000000000005310000001200000000000001690000100300000000000000000000006850051220000000014100237000000000000000000000000000000000000000450000000000000000571668000000000000209000000000000000000000000000000000000000000054000000000000000002260184000000000000000004930000092000000021558580000162000000055000000000000047738109000880000000000000820000001690007411112100390550000000000000000000010913808200000000069000005400000013602287990270011301120004560000870000690000009861815100131000000000236000000000000000000000000000005300000000000534028400000000000018100
SP311Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;denticola00000000521120000000000000000000001270650001629000005300460000000000000000000001990000109560000000000000474200000000136000000000002900000000006600000000000590000700000000000000000000000000108000000150580004235056000000000000010500000000000000025600000570000000000750013900000016917404102404600326000024499000001300000001111588131900000000000340000016129197018300000460000000103000002551230000540114000213000512200000051000471931440000001320000000023000001930056000000008400000082000004332917500008900112148132001490270089000000000000000130000001531130000000000000072146000271000000000013100003600000133000048074000100000000000010507207100007100000047120000000031580024060005209203600720068000000005600028000000000000000001500000000000109000174001703907234000000150037545430040000000000031000000000000880000000000000000000652002190000000000021063381320000000190
SP312Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Schaalia;meyeri145200000007400066000000000000075000750000000000000252000000000000000000000000000000000000000000650000000000000000000000000024103800000000001338600000000000000000002050000000000000000000000000000000059000000000000000000000000000009200000103000670000000010100000000410000950019569000000000000000000085000000000000000000000000000000000000000000000000000000000000000000000000001920072000000000000000000000000000000000000001810000006900000000000000000000000000000000000000940000000007700000008600000001220000000006000000000000000008103300009327210500007700007100000000000008900000000014700016000012600001530000000000000000000000000119000000000056083000000000011100000000000011491000000000001450000000000000000000000000004000000000000000000001110000012703600000000
SP313Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT13700000000000000000000000000000000000000000000000000000000000003300000000000000000000700000000000000000000000000000000000000000000000000000330000230000000000000000000000000000000000000069000000000002000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005500000000010300000000067000057001850002700000740000000000000000016400350007200009800000000000000000000000000000000480000092000000000000000000000000000200000000004900000000000004000000000000000000000000000000000000000000000000000000000000000000001500000000000000000000000000000000000000000370000000000000000000000000120000000000000000000073000000000000000000000500000000000000
SP314Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Corynebacteriaceae;Corynebacterium;sp._Oral_Taxon_A160000000000000000000000840006500000000000000000000000000700000000000000000000000000000000000000000000000000000000002200000000024001160580610250000000000000011500000000071000000380000000001180000023000000000000082000000000000000000000000000046000000002530124006500000000000000000067000000000000000000000003400000000000000000000000000000000000000000000000000000000000000000000018000000000000010900000740000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000760000000000000000000000005857000000003400000000000000740000000000000000070000000000000004500174590000006500000000000180000000000000000000000000043000000000000000000000000000000000000002000000019000001000
SP316Archaea;Euryarchaeota;Methanobacteria;Methanobacteriales;Methanobacteriaceae;Methanobrevibacter;oralis000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000095000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001220000000000000000000000000
SP317Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Mitsuokella;sp. HMT5210000000000000000000410000006200000000700034000000000000000000011000000000000000000000000000000000011700075000000000000000000000000000000000000000000000000000000000000000005100000000000060050000000950000000000000003200000000000000000000000000000000008400000000000000002403950000000000000000000005400000000000000000000000000000000000000950000000000000000000000000000000010000000041700000000000000000000001300000000000000000000000000000000000000005300000000000000000000012000000000000000000000000000017000000000000000007700590230000000000000000034185000000000000000000000000000220000000000000000000000000000000000000000000000000000014100000000006400000000000000000000000015000000000000000000000000045000000000013400000000000000068
SP318Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Micrococcaceae;Rothia;mucilaginosa000163000000000056000000000000001940378063580000000000011860000113184000041007100000000000000000070000105006800000422070227540012400000719000002390002318000000005400125000004100000111130000000000000014500000000000000000000000067000009945001350038800000013900000820155114188000015000012200578210000219780000000000001800025200029400000000000000000000000000000000000000004150000000004320000165375002278600001940000000140005900740000164000000001180000000000000000000038900000136000192131000000000001020000000000000000000000000000000000000000000528000000000000168134000000024600608005100011970450000001914913601310002260000003574217008702051590003734300104000450000000000002210000000000000000000000710080000006500450011400313000670137025500352247001140001580061052000000000000000000000000000000000001050000080028042324900480850016011100307939694000127018300015200000039501692600009600000000000000
SP319Bacteria;Firmicutes;Clostridia;Clostridiales;Ruminococcaceae;Ruminococcaceae_[G-1];bacterium HMT0750000020000000000000000074047000000002200003100000000000000810006500000000000000000000000000037880000000112000000720000000000000000000000000000000125000000000000000000002300000000000000000000012100126000000000001300000000000000000000000000000000000000000010300000000000000000008591000000000000000000000097000000000000000000000146000000000000000130000053000000000006000000192016700000002030000065000033800000000000000000000001190000025400000159000000000000013200000000000000249000000054062000000000000000000000000000000000000000003100009800000000000000220000000130009507746003700146000000330000072000000000084000000000000560000000000000000000011800090000666300000490004516006000100000000000000058000860000000000000000000000940080000006900000000404300004500004504500068
SP32Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT45800053000000000450001490000126000000014700138000000001500960490000000220000012306300280000138073000000000000000000000000000910000070001120000001240000000000171001630000000670000000000000430000000138004700000000001430000003600250173000053000166137000000000000000000000000000000000001280000000000000780000002110000000000000177001680000035500000004170034900001610000008510000000000022500107190000000000000000000000000000000499000027800246000000000067043800000000000077208420460000000000000000000000000020700000000000000000000000011431847800280000311000000000000000000000000006756038000001360001700000167674400001530000000000105067000000298000000000880033000000390018014000430001040031000000000000000000000000331043082000012100006500066860600000000540000000052540030172170000004600137000062000000000000000074000000000000015000000001200000064
SP320Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;granulosa00000000011000060007700000010500000015009300001060000000000000048000102000000000000000000056000000006700000000000000820000000001260000004900030000000000000000000004200000006401300000000000004800000000420060000007900100000000000000000000000000000001000000000000000000000000000000000950001170000004900396423000000043831897000000000078003300002780001410168000000000000810022000000000000000000000000000000168022401150026600045000000000155033500008200000000312000000000000132016092021401580022300000000003690001143270734075001960000293016900000000003290000000000000000000000000900000000130000000000000870000000001800019600000000000011700000000250000063640000007600000000019200000000000004000002506209700013820224615000000470000031003205815800000013619000157000000289000000012250000001800000014623700000000360021700036113000012502900000014103080000
SP321Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT2580000000000000000000000000000000220000000000000001500000000000000000001000000000000000000000000000000000240000000000000000000000000000000000000054000000000000000000000000000000000000000000000000000000000000000000000001720000000000000000000000000000000000000000000000000000000000000000000000000000000000260000000012500000000000000000000000000000000000259000007800000000050800000000000000000000000000000003200000000033081000000000000000000000009700000000000000000000000000000000000003300001680000060000000000000000000079000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000200000000021000000000000000000000180001600000000000000000000000000000000002400000140000000059
SP324Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Mogibacterium;timidum01022600000010706168000000000000000000719600660141700000163000420000000868400000000110220011400010000270000000070000059000000032768000002300920000000001500057000084000000076000000002800089160000009000000424029101000000490000000072310000000010800041000110113000000000830000000000180000000000044000206200230000000023500014617000014450000380000574200000000000000156000100467136116102440003080204000148000162000181780170000001441520002283960035417300000000002769900005400000000003709916902230351015801890000016310400000000001120250060000000219155254001341720001200008754000093003761360172014403002790087000033000000001950270950048708100009300007500000000038450000071000000004988460000000000560900014367100175090110024000001700130006703140000000014100541940210000000000002303700000000000013300000000000303300000000000005800350000790093000000000000311000000001040060330000012769021800000002500101000143706500390152000
SP325Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;enoeca0000000000000000000000006200000000000002900002800021000000000000000000000000045000710000000000020000000000000000000000000000000000000000000000000360000000000000000000000000000370000000000000000000000000000000000000000000000000000000000000000000000000000000000080000000001243005200013000000400000000000000001000001800019000000000000000000000000041000000190001400000000000000036000000009000000000000000000000000000008000000000000000000000000000013000000000033100001400000000000000005302604900000000000000000270000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039000000000000000000530000000100000000000000000000000000000000000000000000000000000000180000000000000000
SP328Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT136000000000000000000000000000000000000000000000000000000000262300000790000000000000000000000039000250000000053000000000000000000000002700010800000000000330000000000000000050000190000061460000000000000019000000000000000000000000000000000026000000000000000000000000460000000000055000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000140016035000000000000000000000000000000000000000000002600000051000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000030000000130000000000000029000000046000000000560000000000000050000000000041530000000000000000104500000000000000000470000000000000000000000000000000044000000000000390000036
SP329Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT1330000000000000000000000000000000000000000000000000000000000700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004400000000000000000000000000000000095000000000000000000000000000000000000000000000000000000000000000000000000000000000001190000000000930000000000000000000000000010900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046000000000430000000000001200000000000000000000000000000000002600000000000000000000000000000000000490000000000000031000000000000000000000000000000000000000049000680000000000000000000000006200000000000000000000000000000000000000000000000000000000000075000
SP33Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sputigena000830000000360420000720002800000073000068000000078000000000000006400011600002200000000000000000011000000000000000000000000000000000001560011400000001020000000000002300000008300050000002900000000410170073162000000509200000011600001970000000300000110000000000000000246016702650020400000000634700309510019301280172259920003640001370000047000132000061217320244000000000000000000000000001140000000000000000000000240000000000000000203000000000000000000000001770000000196034001930740000058127000065000000000420028900370042720500106000631163200000000000871520000000000000211004090000000000004000000000650178000185000061001640085002221410870003700042240105000650600720380000000036115017158000019001600000000000002700000000000124000000001380000910000051317615400250000009207500672670730004413858100020103300000198000004900200000000000000056000040000196004702566000057
SP330Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT14600000000000000000000000000000000000000000000000000000180002800000000000000000005400000000000000000000000000000930000000000000000000000000320000000000000000000000000000000550000000000000000000000000000000000000000000000000000000018401900000000000000483722000000000025000000000000000002700000000000000000000970000000000000000000000000000000000000000000000000000000000000000000000083009000000000000000000000000000000000000000000000000000000000010800000000000000000000000000000000000000000000000000000007200000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051000000000000000049000000000000000000000000000000130000000000000000000000000000000000001000000000014000001200000000022
SP332Bacteria;Firmicutes;Bacilli;Bacillales;Gemellaceae;Gemella;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
SP333Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT2840000000000000000000000000000006500000000000000000000000000000000000000000000001530000007000000000000000000000004400061000000000000000000000000000000000000000000000000000000000000000012700000000000000000000000000000000000000000000000000000000000000000000350000000000000000005200000000000000000000000033000000000000000000000000000000000000000000000000350550000000000000000000000230000000000000000000000000000390000000000000000000000000000000000000000000000000000000000000000000000000000000000000220000000000000000000000000000000000000000000000000000157000000000000000000000000000000000000000000000000000000000000000000000000000000000000314400000000000000000000000000290000000000000000000000000000000000000
SP336Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT29200000000053000000000039260000000000000074011750000077000000000006206900000000000000000053000000000000145000000093000017100000000000000000000000000500990000000000000000000000000000000000001140002500000000000000000000000000000000000000000000000000000000000000000560000000000000000000000000000000000000000000000510000000000000000000000000000000000000000000000940000000000000000104000000000001480000660000000860000000006213000000004800000000000000000000000000000209000000000000000000000010900000000005504300000000000000000038000000000004613106400360000000000000000000000000000032000000019000000000000000000062000000000000310000000000013000007700000000000000000000000004400002500000000000000000000000000000000095036000000000008200000000000000
SP338Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;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
SP34Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;leadbetteri000000000007001310000000037108136057000428507500001150001390000000004333000116000271000000000014500000000000000125000000000000062000006600000000320450011601521420189000004001804100007200000540000002766620500000471020930002500179243368510700016900001070007200025000029304500000000000000000062000000000007411042801590000007700000001800405002392071800001980073225292000001983820114269000000028501648200362000027300000871060000001480000000000000511001090003000000114000000000002760000639008300058009700021606000001880000072017901497800003025012900021700880454580000000155532409500130000020800380018000190011002290842251790000000000000040138000024700800080145000520010912800005700000102160000105049084007300036001719122800000009310900048067017713528900157000470003353041360000167801196816600000000000000000780001074322816400000035600008201872000027700006412700014701082171091911036010802195323247095075033023900000600770003805700820000016110400571060624811200055222007400440199067058570
SP341Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Oribacterium;sinus000000000480660000019000000000000000000001120000000000430000000000000000000000000000000000000000000054000000325000000000000000000000000000000000000001130000013900000000000000000000000000000000460002907700019000003500000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000120000015000000000000000000000000000000000000000147000000000001830000000000000000000000000001640014232600000002060000000000092000000000000000000000000000000000000000000000000000127000310000000000000000000000147700000011000000000000000000000000000000000000000000000240000000000000000000000270000000000680000002000099000250000530000003200000000016900000000000001780000000000000000000000000000000000000250000560790000022300440600
SP342Bacteria;Actinobacteria;Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Parascardovia;denticolens0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007600000000000000000000000000000000000000000000000000000000000000000490000000000000000000000000000000000000000000000000000000000000000000000000000001180000000000012800000000000000000000000000000000000000000000000000000000000974000000000000760000000000000000000000000000000000002080000000000000000000000000000000000000000000000000000000000000000000000000000000000000000480000000000000000000006000000000000000000000000000000000035000000270830000000000000000000000000000000066000000000000000000108000000000000000000000000490000000000000000000000000000000000000000000000
SP343Bacteria;Firmicutes;Mollicutes;Mycoplasmatales;Mycoplasmataceae;Mycoplasma;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
SP344Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT93700000000000000000000000079000000000000000000000000000000007900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000076000000000000000000000000001200000000000000000000000000000000000000000000000000045000720000000000000000000076000000000000000000000000000000000550000000000000000000000000083000000000000000000000000000000000000260007200000000000000000000000000000000000000000000000000001330000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000140000003400000000000000000000000000000000000000000000000000000000000000000003700000000000000002100000000000001600000000020000000000000000000000000000000000000000000000000000000
SP345Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Johnsonella;sp. HMT16600000760000000000000000000000000000000000000000000000038000540000000670000000000000000000000000000000000000000000000200000000000000000000048000000000000000000002900000000040000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027200000000000000000000000000000000000000000000000000000002070000000000000000000000000000000000000000000000016700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000310000520000000000000000000000000000260000000000000000001600000000000000000000000000000000000000240000000000000000000000000000000000000000000003400000000000000000000000000000000000027015000000000000001450000000084000
SP347Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;sp. HMT4960000000000000000000012600000000000000000000000000000000000057000000000000000000000000000000000000000000190000000000000000000000000000000000174000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007800000000000000000000000000000000990000000000000000000000000000000000000000011400000000000000000000000000000000000000000000000000000000084001120000000000000000000008302400000000068
SP349Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT9020000000000000000000119000000000000000000000270003900000000000000000000000000000000000000008000000000000000005900000580000000000000000000000000000000000000000000000000001100000035000000000000000000000000000000000000000000000000005300000000000000000000086000000000000000000000000000000008300000000000000000000000009500000000000104000000000000000000000000000018800000001560000000005200000790000000000000085000000000000000000000000000000000008700000000000000000000000000006200000000000000000000000000031000005300000000000480000000000000000000000000000000055000000000000000000000000000000000000000000860000000000070000000000000000000000083000000000000000000000000000000000000000000000000052000000000001050000000000000000
SP35Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Bacteroidales_[F-2];Bacteroidales_[G-2];sp._Oral_Taxon_27400000000014002100000000729800005549890048056088048300000016900370000036190067000000150000229000147001010500030080090073071000500053074330000012302854006001900020356001019300031000007400052010100006500036095000000000000129000019000150269605400004461010000000033000212002000028000000003930000000001320420000001632050000001096970131000000000050206111400114000000560021153015900000000000380000021100852691010000000065000056000013204519000105632420000033390000000152001161073470271092001547900127002704205900851112201180082000145136001340009202600270129000620205360388446000000001040000000001200847713403900006202370000000210000000000109009100000772060654492141800226000000002104800017000000000000216292903918000068071010577037007100475300000820038311834305000002970000094014700032405800201015200497091600000536035200000079000000690023958430550000035050007914110144063076000073000002800000006200017921303001600046058480115086960003607441000000530331012106038056300430081017809573
SP351Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT30400000000040000000000000000000000146000000000004000000000014800000000000000047000000000000000000000000000000000000000004600000000000000000000000000000000000200000000000000700000000000000000000000000000550000000000000000000000000000000000000000195000000011300000000000003260000000000017000000000000000000000000000080000000000000000000114470000000129002790000000000000000000000000000002400002980000216159000000000000000000000000000000000000600001690000000000000000085000000002770000000000010500026700000000000000000000000000004900000000000000480000000000000800000000000000000000000000000000064000001140000000000000000000000000000000000000103000000000000000000000000000000000000000052013000191000000000000000000000044000000000000000000000008358
SP359Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;canifelinum00000000003800000000000000000003800000000000450000000000000000000000003800000000220000000000000000000000032190000000000000031000000000000000000000630000000000000000000000000000000000000600000730000000000000370000027004400000000000000000000000000000175000003806200000000000000000000000000000000000132000000000000000000000000000000000000000000043002100000066000790000000000028068000004600000000000000000000000000000012100000033000000056000000000000000005700000000000000000000000000000000000039000270000000000016000000000090000029000000000000000000000000000000000012000001900000000000000002800000000028025000000000000000000000000000000010000000000000000021000000000280000000000005000000000937000000000000002200000000000000000000000
SP36Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;loescheii00000000000000000000001000002250000097000001330000000000000000000000146000000012800000001550000008300000000000000000000000000040000000001440317000001210000000430050000000000000000000000000000000375000000126151840000000000000000000009700000000000000233000000000000035021900011200199014700000097009154120000000000000000000065000000000003300000087003250000002130000000000000001090000000000001460205000000000000000835001710174126000001310018400000000000000000000000000076990005340000000000000000000000000970012501760000000000208000000020400000001201100975500000000434500000000000000000193000002720000000322000000494107269000000000000001710011600041013705700000000000097000000000070000000000000000355900012200106277000000000000000009800000013800000000000000008762000000005200000136000000000000000071000008400000002890103000000
SP361Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT448502716434703317905266835035717980001074014080001293100057400001901470001269313411905699230000447579445703328005750207012760083777502565600782590028922252410000206918306070562300025900001821000262369300212125430034436041651702040710016020207703609462220371131000010105511950013660000124401591167010243652260102572270750004760000362015998200312153902310000134000001980132907200029318120001600002404231660017102050300209002868081600226431704740341092346402280290000926000000729000000036300172917852217619000000021150062756118200029535314000000007131648000000000147732410084924906260096028809930067902245000207103961010780339307160019850112003410395502117299800000000000000047020000152705470001015109502254399737740000000185000769000000000022712430455182165700000808000002490942165801135016740011200532057180000017600002278030100000001870001803009425180000000627704659001982870240000760113200013049010714801260590002323320001077000000831052491050000820117312326400105000041301264751213013364550766000000000003424740049997254000029011538226560000151982861001519055430017224200907852484000101210105314740015740000148000599318701626516840000001264057900000698000000830000034671171001550945194245601649013503431586010650089464950260005110062021630083504300000001690149403192100000090100033000
SP362Bacteria;Actinobacteria;Actinomycetia;Bifidobacteriales;Bifidobacteriaceae;Bifidobacterium;longum0000000000000000000450000000000000000000000000000000000000000000000000000000000000000000000000000000000000000190000000000000000000000000000014200000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007300000000000000000000000000139000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003700009000044000000000000000000000000000000000000000000000000000000000000000000000000000000000000500000000000000000000000000000000000000000000132000000000000000000000000000
SP363Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-3];bacterium HMT280000002300030000000000006000000000460002300000000000000000000000000000190004700000000000000000000230000004500480000000000150000000000612400000000090000000000000016000000000000014004600000000000000000000000000000045000000000000000000000000000000000002000000000000000000123000000000000000000003000000000000000000000000000016400000330000000003100320036000003700000000000000713200000003700000000000001801400000000000000000000000191000000009100001220000000000000000000000000000000000000000000000000000000000000000000000000000000000640000000001600000000000000520000071000000000000000000000000000000122000000000000000000000000000000000000073061000000000000000000000000000000000000000000000000000003800000000000003600000000000000000000000064
SP364Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-6];[Eubacterium]_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
SP367Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT257000008900000650000000000000000013001220000077000000820000094000000000000000000000000000000000000000110000000001310000000000000002600001300000000000000000080650075006702100000015700001116200000000000000000000000008200000000000000000000000000001200000000000980000000000000001200000008814000820000000002111630010300000000000000000024004700000346000186000000000000000000000000284000000000000000000000000000000000000000062000000000000009200001022360200000030001240000000000000000000001260000135000370000200000000000000770000000000000961090012000000430000000180087000000000208800000000000000022590000164130024000000016001800000000025000000000490000000000000000000000000000015300080015500007200550000000000000000000040000010700003900025000000000000000000006500000270000000065000590240000006684
SP368Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT898000000000000000000000076000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007500000000000000000000000000000000000000000000020800000000000000000000004800000000000000000000000000000000000000000000000000239000000115000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008200000000000000000000000000000000040000000000048000000000000000000000000000000004300000000021400005600000000000000000000000000320000000000000000000000000000000000000000000000000000000000000000
SP369Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;elongata0000000000000000000000130230000000000800000000000000000000870000000000000000000000000000000000000000000000000000048000000000000111910311680000000027970000000000000000001910133000000580000000013222515178000340000000000000000000076000000000000000001870000000000000504070733540000000000000000331000000000907000000000445000290000000170028100002400000000000000000000000000000000000000000000000000000000000000000000000000000000000001500000231000000000013000000000000001980000071615200002302100000830000000000000000071000000000000004000005300005700000000000000000060000000000184000076116000000006800000504450081055000001460082048121000000011047110000000000000001800000020501020820200420000002800007201010018749000023001280030500000001880071001380000000000000000230000000000000003170000085000000005000220
SP370Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;micans0000000000002800000000000000000000000000000000000000005800000006300000000000000000000001030000210000000000000000000000000000930002700000000000684800000000000000000000000000004200000000000540000000000000000000000000000000000002400000000000000000118000000010676000000000000002330000002600730001360000000000000000000880000000000000000000000000011000000000000000000000000013500000000000001500000000000000000000002400000000000000000000000000000011200000000000000000000000000000000000000000000000000000000008000000000000000000000000000470556600000000006200000000000000000005900000000004900000000000000000000130000000000000000000047021016000000000000000000000000000000000000002900000000000000000000900000000000000001210440000200001000000
SP371Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT13400000000001300000000057138000000000000280000000000500000000001090180003500038000000006200013700000000078000000000000000000005000000000265840000006900000000000112000000000000001430000000000350000000000510000000000065001100000000005500000000000000000000000000000000000000137000019700000000000274000000000106004000099000000000000629303770000000000000044014000000225000000970000000000000000006300000000000000000282016418100014200030300000000019027300000000006400093000058000000077000000000057017100120048006000020300000000000001110000000003100000054000000000000000002800003027000093006900003400003400000000000000000000000000000000760000600000000210000000000000061001800000000000000000000000000000610000048007200000340230140000000005400041000020000000350000003754000490000000000000000038000000
SP372Plantae;Angiosperms;Eudicots;Malpighiales;Euphorbiaceae;Manihot;esculenta_Oral_Taxon_C60000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002100000000000000000000000000000000000000000000000000000000000000000000001400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000060000000000600072000000000000000000000000869000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SP374Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;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
SP378Bacteria;Bacteroidetes;Bacteroides;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp._Oral_Taxon_B94000000000000000000000000000000000000002700000000000000000000009000000000000240000000000430000000000000000000000010900000000000000000000000000000000000000000000000000016000000000000000000000000000000000000000000000000000000000000000000000000000000000001060078000000000000000000001570000000000000000000000000002820138000000000000000000000470000000000000000000000000000000000950000000029900000000011300000015800000000000000000152000000000000000000022000000000000000000000000000000000000000005766000000000000000000000000000000000000000000000000000000000000000000000000000690000000080000000000000000000000000000000000000000064000006000000000120000000000000000000000000002600000000000000000000670000000000420000000000000000
SP379Bacteria;Tenericutes;Mollicutes;Mycoplasmatales;Mycoplasmataceae;Mycoplasma;salivarium00000000000000000000000093000000000310490000000530000000000000000000000000000000000000000000090000000000000000000000000000075000000000000000120000000064000000000000000000000000000000000000000000000000000000000000000000000000000000000000073000000400000000000000000000000000000010400016300000000000000000000000003600000000002900000000000590000014600000000000000000000000220000000005200000000000000000000016300000000000000000000000000000000000000014200000124004700000000000000000000000000180000467100000000000210000000004300000000000002100027000510000000000000000000036000000000420000000490000000000000000000000000000000000000000240000000000053110000000000000000000000320000000162600000000000510000000450016000130000000000000004400000
SP38Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnoanaerobaculum;umeaense0000004900000000000000000000000000000004200000000000000000010300000000000000000000000000000000000000000000000000000026000000001000000000000000000000000000000006112700000000000000170000031000017000000000000000000000000000000000000084000000000000000065000005200000000000000000000000111050000000035700087000000000010511000000000000000000000006006300033000000007000000000000000000002240600000000000000048000000000000880078000000000000000000000000004300000000000000000000080000000000000000136008000000000000010000000000000000000000000000007500000420000000000390000000000000030000023000000000000350000000000000000400000000000000000000000000000000000001500000013000000000000000000000000000000000000000021007800000071000000000001419000000000000310
SP380Bacteria;Gracilibacteria_(GN02);Gracilibacteria_(GN02)_[C-1];Gracilibacteria_(GN02)_[O-1];Gracilibacteria_(GN02)_[F-1];Gracilibacteria_(GN02)_[G-1];bacterium HMT8720000000000060000000000089000000860000000320000000000000000002600099000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000250000000000000720000000000000000000000000000000000000000057000000000000000000000000000000000000000000000000000000000000013800000000000000000000000000000000000000000000000000000000000000000063000000000000000000000000000078000000000000000000000000002300000000000000000000000000002800000000000000038000000000000003800000000000000000003000000158000004100000000230000000000007000000000000000000000000000000000000000000000162074000000112000000000030000000000000062000030000000000000000000000000000000000000400000000000000011200000000000
SP383Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Olsenella;profusa000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014270000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001180000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SP385Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Haemophilus;parahaemolyticus00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007400000000000000000000000000000000000000000000000000000000000000000000000000116000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001470000000000000000000000000000000000000004000000000000000000000000000000000000000000000002102000000000000000000000000000000000000000000000019000000000000000000000000000000000000000000000000000000000000000000000000387000000000000000000000
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SP399Bacteria;Chloroflexi;Anaerolineae;Anaerolineales;Anaerolineaceae;Anaerolineae_[G-1];bacterium HMT43900000000000000000000000000000004700000000000000000000000001900000000000000000000000000000000000000026007100000000000000000000060000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000095000000000000000000000000000000000000000000001400000000000000000000000000000000000000300000000000000000000000000000000000000000000000000000000000000000001060000000000000260000000000000000000000000014000000000000000000000000000000001000000000000000000000000000000040000000000000000000000013000000000008000000000000000000000261210000000000000000000000000000023180000000000011000000000000000000000000000000000000058000000000000000000043000000000000480000000008058000
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SP403Bacteria;Firmicutes;Clostridia;Clostridiales;Clostridiales_[F-1];Clostridiales_[F-1][G-1];bacterium HMT093000005300000489500050000110700000003800000000000000000000000000000000000000000000000000000000000000000000000000000007100000000000000000000000000000070000000000000000000007700000000000000000000000000000000000000000000004800000000000000000000000000000000000013500008800000000000000075000000000000000000035000064000011300000000000063025029000010670016900000000000001070000000000000000000001130096001080000000000000000000000000000007718722900000000000000013000340000000001156600020900000000000008406500000000008803900290000000000004500000000000072046000000000000000000000640000000000052000000000000001500086000000000000000000002531000000000008200054000034000293500000000490000000000035000000000000038030000000000000000000000000000000000000080080580002953
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SP417Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Atopobiaceae;Olsenella;uli109000026100000015800000007141690000000000003400000000000000000000388000290000000000000211170000980000000000000000000053600000000800000000000163000000000000000175000000000000000590000440000000552070000000000000000134006000000000000002040640000000000000000000023700000000000000000000000000000000000000000000000228000000000000770000003210000000000000000000000000000000000000029213000000000000000000000000089001940019500000000000000004460000000000003220000009900000000000000000003170000000000010900830000000000000000000008800000000000000000000009500013500000000000000007500006900000000000057000115000000000000000007800001000000000450212000000000000000000000000000116000001080063000000000000000000000000032000000000000000000000000840000000000178277013200000000870000009000017200000
SP418Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-4];bacterium HMT3690000000000089005700000000000000000000000000000000000000000320000000059000000290000000000000000000000000005200000016000000000000007800000000004400000000004000040000000000000000079000000000000370000000000000000640000000000000000000000000371020000000000000001851850000000010700000000000000000000060000000000000000000881670000000000000000000001004317400000065000000000000000000000025000000000000000000000000000000000000000000782300000000011701150013000000000000000730000000000000000000000000000234000870000000000000004250000000000000000006900000005200007800002900000005100004700056000800000007000000000000006800122200000000020000018016000000110000034000690006400052000000000000000000000080000000000000000127000000000000000000000000000000000355930069200048088000
SP419Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT2620000000000970000000000000000007000000000000000000000000006968000000000000000000000000000000000000000000000000300000000000000000000000000000000098012003900000000000000001210000000031970000000000000000000000000000000000000001050650000000000000000000000002300000010400760000235000000009400047000007000000000000000000000000065000000000000001860000000000000000000000000000000000001220000000000000000000000000000000000000120036000073008212400000000000000000000000000000000000000000000000000000000000000000006500000000000000000000000000015000000005600000000000043000000000000000000000000580000000000000000000000000036000000000000000077000000000170000000000000000000000000000000000000000000000000003900000000000000000000000370006600000
SP42Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;rava039000000200001270000000075000043000046436500010761004000011000000560440000000000042000104000700000540000006546001400002400020145300000007700000000000156490320000071000000500008006800910000155002609806405100600008500430180151000007400058005200001610000000390019240000000000000079000079000000001600000000020800090001280000180000000710670001101300176116000000000054370000000000000018001260240000092000095680000000001600158162000000000620008600000000000000920000801310181000710000000013000000280990016017100151000000001290000007711300000000002040000001300000000010000000000000000011212300007716043012201600000000270007400691658000780000002542000000530971020001290008000072880720830000000650960000000138020730000000091720000000003100006100010000000000072000022126000000960000026009100000040680015500240000000000000015900000000650520015000000510000000000210290001020000000096108
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SP422Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Peptidiphaga;sp. HMT183000623018503070000178000023901590000006951160000660340360016301200000000000000386000003111506401740026120025101616544200047400000060401681000000773026500000156000000093602570000384000174302000043305300000002600000613015700000217462000000000037600002082000014170004286863590000000000000000300000000000180000004943137000000000000000000000000000073000000000000000001973361132520003180000094773000038200000002450000000000014300271300000053400013931003008321360036800890000000000000000000238900000000306000000000000013090000000001017007448028530012003861010000000522000006280000000104720000000000002810003565102900012510000000000000003580005830000042600000004539200000314162000000001900004890483700004040040000275000005020001508000000000306000032600005110003440540002210000000050526429001070483000013543000360004960000000000126200036000175222004422800000000245059041200155563820088400054310089036900012823333007685200000421000000000000000140000000000084000000146900008900000
SP423Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-2];bacterium HMT09100000000000370000000000000000000000000000000000011000000000000000000000000000000000000000000000000000000000000000000000006000000000000000000002500000000000000000000000013000000000230000000000000000000000000000000000000000000000290000000000000000003800000009900000000000000000000000000000000000000000000000000680000000000000000000000000000044000000000006400000000000000000000000000000000000000000000000000000000000006152000000000000000000000000016900000000000000005200000000000000000000000000000010023000000000000000000880000000000000014000000000090000000000000430000000000000000000000140000000000000000000000000330000000120000000002300000000000000000000000000000000000310000000000000000000000000000380000000000
SP425Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT95100000180000025022000000000000000000011000000000000000000000001900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029000000000000000000000000000323600000008600053000000000550004100000000000000000000000000000084000000000000000540000000000000000000000000000000000000000004200000000000000000000000001700000300000000000013000000033000000000000000000000001530004600000000000000000000000000000003500000000000027000000000000445000002000000038002700240000012000000000000000000000000000000000000000000000000000000000000028000460004832005000000000005000000000000000000000000000000000000000000000002400041000000000000000000037000071
SP428Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT3010000069000000000000000000000000000000000000000000000002400020000000059390000000000000000000109059000000008100000000000000000000000001500000000000000047000000000000005900000000000000000450000000000000000000000000000000000000000000000000000000000000000000000000000000000000000140000000620000000000000000000000000000000000000000000000000002200000000000000000000000000000000000000011800000000000000680290000000000000000790000280000023123063000002000000000000000000000021000000000000000000000000000000000000000000000000008000000055000000880000004900000000000000021026038000042000000000000000000000000900000000000000000000000000002700000000001500000000000000024000000000270100002100000000000000000027000000000000004400002100400000041
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SP431Bacteria;Proteobacteria;Betaproteobacteria;Neisseriales;Neisseriaceae;Neisseria;sp._Oral_Taxon_1400000000000000000000000000000000000000000000000000000000000000000130000000000000000000000000000067000000000000000000000000067000000000000000000000045000000000000000000000000000000000000000000000000000000000000000000000114000000000000000000000000000000000475000000000000000000000005500000000000000000109000000000000000000000000000000000000000000000000000131000000000000000000000000000000000000000000000000000000000375000000000000000000000000000000002060000000000000000000000000000000000001100000000000000000000000000000000006700000000000000000000000000520000000000000000000000000000000000000000000000004600029000000692000000000000000000000000729600000000000000000000000000000000000000000000000000000000008500000
SP436Bacteria;Spirochaetes;Spirochaetes;Spirochaetales;Spirochaetaceae;Treponema;sp._Oral_Taxon_G530000000000000000000000000000000000000030000000000000000000000000001030000000000000000000000054000000000068000000000000000000000107000000000000000001400000000000000000000041000000000000000018000000000000000000000000000000000000000000000000000000000000000000001280000000000000000000000000000000000000000000000001050000000000000000000000004900020200000000000030700000000000000000490000000003800000000000000000000000000000000000000000000000000000000000000000003400000000000000000000000000194220000000005400000000000000000005600000000038000013000000000000000000000000000000000000000000000000000000000000000000000000000000003800000021000000000000000000000000000000039000440000000000000000000010000000000000060000000690000220035
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SP449Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-2];bacterium HMT350000001100000000000001600000000000520100000690000000000000000000000000007900000000000600000000890103000000000000000000000000000000000000000000000000000000000000000006100000000009400000000000004800000650000000000000180000000000000000000000480000038000000000000000094000000000000000000000008200000294000000000000000000126000078000005300000000000000000000000000000086000328000000000000000980000163000000000000000000000000002620000000000000023400001920000000000000000000007132400029800940000000000000000000005000000006300000000000005801700000000000000042001543000000000000000013500069000170000000000002200000000046000000000000000000000000000000242800072610005100000000049005600000000240000000000000000000000000000163000000000980087000000000000000000006105190
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SP473Bacteria;Firmicutes;Erysipelotrichia;Erysipelotrichales;Erysipelotrichaceae;Erysipelotrichaceae_[G-1];bacterium HMT90400000000000000000000000000000000000000000000000000000000000000000000000009900000000000000000000000000000000000000000000022000000000000000580000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129000000230000000000000000000000000000000131000000000000000000000000008700004800000000000000000000356000000000000000006100000000000000000000024100000000000000000000000000000180000000003900000000000000120000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000064000703800000000000000000000000000000000000000000000000000000670000000000000540000000000000000000000000
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SP48Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT336200000520002500000000000000008500007606000085000000000000000000000780000000004000000001600000000280280000810280660000000000000000153000000000000000000000002300000320980003800000000780000000000002600000532800001220000000000000000000000046000002400000000000000000000000000001230006400230000000000184000000000524329200001980000000015908700065000000191153000000197500000000000118000000000000000000000510000000000000000000088076000000000000026000000000000153000000001490240000110113000000011600000014800000100001970000115015100000000000000000000000054640000000000000000000000000000000000000007100096000000290000004200000000000000018600000021009000002700000000000211000000002700000000000090000735500000001370000000000039000000360450520000021563007600000000000380000000000000000000038025000000081020000
SP49Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;wadei07100017956600102000241750000153850011600281394770159051135060200138065000000202015300000000531000064521730000150000016313213472100069000960217000001030862180003091710170490770000222180081530000990010000141256023307239100006135625300060452760000007308500001460207000006215200000810324100235011825605600041870002983500093326010839990000000000000019300000126010208079200248019419318520007270086401690800000000701000002870310033927800017300386012200563000645747000499011004300000940437023725660001657000001778001840499009222010000000002300843802875140110617260038401470183000122800005563981265011696201029006780034000000140083111182391610192554042811601370207374000047800002069007680240362022600445300654012704700303006380012290495001660775431245246478027500000005360000914900002590431451854900043000147285051223199000870120980831191421299824386210107523218131000163108032831800394185133720241910001220075745132000218001905530290002471334306600003700165346160114406770653910000044002390881102310001102880003609470420000360490195226315820030101870545460401110024500209161497881851260143042151058014341500023502510000000000001810008858810040721001440000124002910248165262670000367013667700412233
SP498Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;sp. HMT949000000000000000000000003600000000000000000000000000000000000000000000000000000028000000000000000000000000000000000000000000000000000000000000000000000000185000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008900000000000000000000000000000000000000000000000000000000000000002110000000000000000000000000000000004800000000000000500000000000000000000000000000000006800000000000000006500000000000000000000000000000000000000000000000000000000000000000007300000000000000001600000000000000000000000000000006500000000000000000000003600000001120000042
SP5Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;parasanguinis_II2412619820119001718010300000000011340001705000007000002060003955000003870273380187009605660240000069700183371069400002865490085901830257500027101300521112001852990000102043538010080022106500004874060222000013050000880000720000222364024616970900019137304800103194001381567179213804100000000440000000000011390032186084116000001751930052000008510591106100553032200896000031312502825603552638635300000000001300307301825420000000000015042890000017850016500000000790000632003550031403530000237727004399000004440020606730206002335000099107224003218890403000000001199001192358000189800274118400005300000006223440861082007000016603632364000006540000027614001810000525147500113801707098013603230002231067435544028313540000070089100802000000000563011158723000070512403486291510072621385004900002054004980000174006145500156790004408434440007320014700468000355380007190054119620127620000003906930000000052500032458930000001210154102008246602108480097200047118005172201581398012800001723690000000027200720000014401891710000000019200000340133400040821700017870591002676601220011811720000203000000540820098000126575200024000000003180000
SP50Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-3];bacterium HMT3510150000000190900000100119000000011412900135000000058000000000000920001900000850000000000090008500000000008600000000000000000000000000000540000000000004801700000012400000000000000570230000000000000000000101000000000000000048000000000001100000000000153000000000000000000390007800129000000000006700000540246000000019700011400000201010000000119000000000010500000000891410560000000000000000000000000081000000014700000053000000000119000000001300116076335000000008800204000000000066000000000000000012300000125000170000630000000000001300000000000000130062000000000000008700000000880065000126600920000000000004300077008700000215200000060000000000000000000290051001301325000076000000000000000010760086000006700000059001500010000113008300098000000000000000000000000000000000000000000000005600079001100900016000
SP504Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Atopobium;rimae0000000000028000000000000500000000004200002300011000008000008700012000013170000000000008004300000000000000000000000000180000016000011000000000250346490000000000002200000000000000190000000032000000900000000000000000006302500004500000000000030000160000000000000000035000069000103000000000000000000001210000000000000000000121000000001390000104003700012800054400000000009700000000000000000000000750007800000002900006700000008301100000000055000000036000038000750000000067006065001000071000057000140000000011310800000000017000020080000490000048170048000170150000062000000420440000420003200000000008002809027000000000000000000008004103000620109004416000000067000220022000000003500000300025080000000044030000000430004501900000024400004900003400000000000000000100800000000000000280000001800000
SP509Bacteria;Absconditabacteria_(SR1);Absconditabacteria_(SR1)_[C-1];Absconditabacteria_(SR1)_[O-1];Absconditabacteria_(SR1)_[F-1];Absconditabacteria_(SR1)_[G-1];bacterium HMT8740000000000000000000000004300000000700000000000000000000000000000000000000000000000000000000000000000000000000000000000000001020000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001570000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002330000000000000000000000000000000000000000000000000000000000000000000000000000005000000000000000000000000000000008200000000000000000000064000000000000000000000000001190000000000000000000027000000000007600000000000000000000000000000000000000000000000000000048000000000000049000000000000000000000000000000000780000000000000000000000000005100000000
SP51Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum0318312730104035559016111614774732139247841351089107899124387013610932102639053868682079422312029721438433727701970261476014100002460082853082002181770490181753744241468763201480260250045123230508813519510101003520630216217257001077719785985502279500023225063015620752160001576847822500185805153517825021496243001317322801691019038522844719300210767902106232513138624515151002689631746222221502397581560580218210076000038501430205061793610157280001810062007750000019332960032720136823802030289014611361796500702902421138286394704003160247877801449221282157032737703315170642198284364260004107217712104094204143101590521192002550685002900189148607128105688000188847406361507051500003394611005151080000051228605793871202041413050011591413550108548431731585681456464001303642575631831637705460429911923905847003531981683514641900005310280214002520016304245832162730024704491716129501547813016413401701333721186317105321761557129005060100049535111054665504640330515043818220010422064114041524505702450052900488343150200155522001359950218463053725711975723400104910263222840021002738754933014302540449037605621417599518342375272161175377651411208274120307361146627902102381573020122156322925837060840153004231484123583104493215845105103493850181413614500001423415122152335712939123100168696334657114753400194912103635600062144371027401390106243280396438307022610152971503862152437119448332005226828123141972020002801620407613121722581357876021816510400115115355272224000167033233019211301052450232409457150790116085570003273176260362580079000692259101232166210943158281025226712435333546130
SP512Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT3760000000000042000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211000000000000000000000000000000000000000000142000001180187000160000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108023700000000000000000136000000000008900000000000000000000000000000000000000000000000000000000000000500000000000000000000000000000000000000000000000000000002600000000000000000000000000000000000000000000000000000030000000000000000000000000000000000000000000000000000000000000000000000000000000
SP515Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT277000000000000000000000000000000000000000000000000000000000350000000000000000000000000000000000000000000000000000000000000000000000000000000000380000000000000000000000000000000000018000000000000082000000000000000000000000000000000002900000000000007200000000000000000000000000000000000000000000000000000690000000000000000000000000049000000000000000000000000000000000000000000000000000000000000166000000000156000850000000000000000000000000000000000000011000440000000000000000000000004000000000000000000000000000000000000000000000000000000000000000070001000000000000000000000000000000000000000000000000000000000000000006700000000000000000000000000000000000000000000000000360000000000000000000000000000000000
SP52Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;mitis050050088027901741409956134330300372000018719134433790199231726129350000019629100001280733147349390028651159094563002201679410546708427123160002282013408042350355385092032757300003462308303010165900231678200001110012300109300000111002023702790434621000056100052731740376000105786800002176269004244080033576001655040422596000147928009270287250155120169877204703290196433001540270044629901014300026631131400220775066000540179000373300151556301240100901050018830050023907123846700784800000353073600107061231910592321007230033213548261131115991018212584370227151381929702962860821432405309060815070013090164583121635371611621251821374000122225053722013920796600005539478644640207046563700347393329500145233276031300983089349700479477009765643741204380116544053601334139505212558610846312503230069027310702110004474725100810374000232171900364682740101925001564724701604231161501105815877771560213418107303740378062990001831583085082164402200012615470113921050018414100022749115000004786188252192430705820214700001164630851694901522670161012700710035200721225520873798801470001489542030002300002288000366143254200004930815613982125703120197004260384480352002205843900012300512156790395608163000031835021961742023078500460053514184006211016903320156964652222572085022300001533506911262000093987621679013217032622840472000000001712627803051465896202370001027300042185224331001500
SP521Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Tannerella;sp. HMT916000000000000000000000000000000000000000000000000000004600012500000000000000000000000000000000000000000000000000000000000000000000000000000340000000000000000000000000000000000000000000000000000005400000000000000000000000000000000000000000000000000000000000000000000000000950000000000000000000000068000000003000000000000000000000000000000000000000000316000000000000000000000000000000000000000000000000008000000000000000000000000000000000000000000000000000000000000000000000006900000000000000000000000000000000000004000000000000000000000000000000000000000000520000000000000000000000000000000000000000000530000000000000000000000000000000000000000600000000000000000000000000000000000000000000000000000044
SP525Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT820000007700000000000000000000000000870000000000370000000000000000000000000000000560000000000000000000000000000000000000000000000000000000000000000000000000000000000000700000000026000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051000000000000000000000000000000000098094000000000000000000000400000000000000000000000000000000000000000000000106000000000000000000000000000000000000000000000081000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191500000000000000000000000000000000000000000000000000000000000000000036000000000000000000000000000000000000000000000000000000000000000000000000040000000000000000000000000
SP53Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;constellatus08800064006653011107000000013900000000003000000000004682008600000000000000000113000000000125007900000000000000000000000000010456000000003800000810000000000079000017000000000011950000000240010340104016000000000000000000044000000000000000000000000000000000005214509100051000000000000287000000019300448149000718000000000226000266000098600000000540000076000001140000017400000000000000000320024000877011457000000000000002573000000000001000002593605331370780000000000000000000000241330123000000511760000000000000000000000000000000000000000274000046003702537400000020008930000000000003604504175000560742400000002803680691070830446642088000001800713560272025011600370000000000002900000000000011108004000013005700000750000000000000213901050005108901650057001300000001670000004900062000000000000006200000040007201020000254191015466000000000000461995809900077000720
SP532Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-4];bacterium HMT103000000000000000000002800000000000000000000000000000000000000000000000000000240000000000000000000000000000000000000000000064000000000000000000000000000000000000000000000000000050000000140052000000000000000000540000000000000000000000000000000000000000000000000091660000000000000000000000000000000000000000000000000000000000000000000000000000000000000078000000000000000000000000000000000000000000000000000000000000000000000000000000000000000280000000044000000000000000000000000720000000000000000000000000000004800031000000000000000000000003100000004501600000000000000000000760150000000000000000000000021000000000510000008600000000043000430000000000000000000003705000000000000000000000002000000000071000000000000000
SP54Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT238000007500230000000000000000000000022000000000000000000127000061000000000015000000000000000001400000000000000780000000011900000000000015200000000000000000000450000000000000000052000000000000000000000000000000000000000000000000000000071000580000000000000000049000001100000000000000000890002930000063000000000000000016300000002275400210000000000317000000000312200300000000000007701070000000410000000000044000181000000000000620000000030000000000001390000000000000000000000000000000000000000000000000244000000000000546567000000005300000000001470000000000270000000000007400000000000000000000000000000000051000000000000000000000000000000000000000000080032000008100000000000000000000000000067000000000000000000000082000000000000220000000003000004815000150000
SP544Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Stomatobaculum;sp. HMT9100000000000000000000000000000000000000004500000000000000000000000000000000032000000000000000000000000000000000000000000000000000000000930000000000000000000000000000000000000000000000000000000000000000000000000000000000000700000000000000000000000000000000000000000000000000000000000000000247000000000000000000000000000000000000000000000000000000000000000000000000321000000057000000000000000000000000000000000000000000000000000000000000000000001600000000000000000000000000000000000000000000000000000000000000000000000510000000000000000000025000000000000000000000000000000095000000000300000000000000000000000590000000000000000000000000000000000000000000000000000000000003200000000000000000000000000000
SP55Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;maculosa000005000000803100000073063000047360014001800043118000000800000006400042600000010035000000000022900000001710881400000005900037008400010000026000101590003500000000066056140514849000700050000007601400000440000019647101120009301080000000001200011072330000000000000000000004100000000002510062000325900013308983000044100000452260090041191330631429098229301316011000200163280000000990252300025047000014050000110443201140001055000290800000001430000800144021000035185000220780159044510242810000053000127862501210100126062006810807820754001531240027001936000057011300000112063008200320002441001836040023077740000012203600005800000270018005432000000000000380000000000000004000011400641001960002600681002900033510000870057000027370000000000000042000170000000037000036029000000000000008304055150014260165003500000512618029770000031667018700000000281190810900640000000601600036000346748000000000010396570701000000010405652
SP56Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;sp._str._C30000632732431085938510317816015606552593710000117086383087149094138013750018001249089514225672986408830189921084345014982401236090240502628174198018202820148151600144431335100246277175081303107385702107011150024011555672305876769362029956425773717401039748112505100952271645098301192120472241390810248991032990000044117160027321908571715936149200469061911110226318010704481934017635274375930510100057849104182231851470850026678180362021097554107500013700363833463427500002470075763540056891008136602310583019500171298440037718191102310957215780001295141809679011595562860759108083597914000677225134981958103019912274128215333766263318308401814062219369237147668759801083011462654241686101700391901032146185418855834804441017391211128988434700407258900000125914571171034743455030126800328047916321844103222189106100111733624620016814273231045167136000702011413422062514170500968535599486765021831070500287011302762125131006450058733800167152024984871010082432209904214733512131920161803286650820801661642349223110912151370017567603355187284932230027732819258314380100007754941613393002970104600166606017116179058478053740300708526008401722830053619941460676016317745391872236534785005305920844325322114000102492543572793853259282030415361459641483034521714032985547403070601413589280017735104271225010300060160595528701247634316149610708989347189189142010521722023255632497501102725414622010814263846775790038170465073643204043013226002980024556207102026319718353475206683403230711945100340152312506974130831177398450010860310294816881768067102904414710033794001231543421974907730202531769462037221416261431463190003158800481520481029043310
SP563Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis_subsp._dentisani_clade_05800000000000000004300000000000000000000000000000000000000000000000001000000000000005700000000000000000000000000004100000000000013400000016401100000900000000000005600000000000000000090000000000000001290000047000000000000000004704001200049000000000000000030530000000000000340000300000000000072000661100000320000000000000000000000000000000067099000400510000000000000000000000000013000850000057000000063000000000082094000120003710720000000000008800000050025000000000002070019000000000000000000000041600000000000000000000001600220000000000000000061000000000000000000000000010050010100000000000000000003800000000000000000060000000000000000004710000000003200000000024000000157000000000000000000000003300000000000000000437500000000000000000000000000050000
SP57Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;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
SP58Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;oralis0281454525717356025336231006868503838300000265030153369188305157195952350743461051034947400001181012500959177624054686015211000330847018500029130905504723110683994200429482039200122019208225501540480071003385015239042854933001810379231400120949021401360262387234011661982901730814004547958102481011521050143819902505401261324480062724097107018605168681802302670714010557810462018890000748000850638000276007312229316017424003390000610017700019176003258003891317246171891265963039427601780002551003385640104700561618372581892050010387291462638043914372701034014041570682165039629117183409034475224294632743260267171172021159426147400284318071105401150291588008485792308970002185880260003412939440482144259357002144256620008712880319003780004027261700002290081036607495416117007137591358693165389097248603956483263880297113960133020112037742079217496016801071384836380445392705222038954505022162081120705029920073024633224310754064158128430670111022247674000038066214711000794002693763240000057618921835026390000122291001841490194352490238613722820227055922722126014300112401451340017897510037228718501609125317113306410571482528011064156017165174661081020274836900051900038107172001970107332170242190109314132501963609182504570103980005340670051951130382152251200040265100471601998853557161103192330105721886225909122013102590209788319814254136915604481357911702640000734643001030945313540532507759309637372592290095101600141161650026801183093453712232326511425920991164808651295250011839
SP583Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;sp._Oral_Taxon_E830000000000000000024000000000000000000000007600000000000000000000000000000260000002100000000000000000032000310000000000180000000000000002400000000000000000000000000000000002900000000000000000000000000000000000000000000000000000000000000000000000000000000000000012100000013200000000032000000000000000000000000000000000000000000000000000000000009200000000000000000000000043000000000000570000000000000000016200000000000000005700119000000001080000000000000000000000000000000000000000000000000000000006200000000000000000000000000000000000570030000000005100000000000000000000000000000000000000000000000000000000000000000000000000000034000000000000000000000005300000000000000000000004300005200000000000000000000150000000000
SP59Bacteria;Firmicutes;Clostridia;Eubacteriales;Eubacteriales Family XIII. Incertae Sedis;Mogibacterium;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
SP6Bacteria;Firmicutes;Negativicutes;Veillonellales;Veillonellaceae;Veillonellaceae_[G-1];bacterium 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
SP60Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;denticola1717171047263710010912469000029011617611300000921230000329842510393221314157088011622300186035717113101321311247400224001000787500008652440218685601214500227000014206104323200001422809900250183032400065000000050158010600000003405304530241000015200552560169014800130000072015104360010724800000283254700247090086027310600830108116000000311011614707212965802196003161020000001460037323194600108023052000027012900011100950322082300384615535008958841006200850290156064173498586003431500155283080002261150162393092667006800001490850355221090056100037917148304520000194110725031340520429790004971560712340188001342941580000000691510022401710425000392134024301305202381645821001921000000142441061757019339106230011967137900000071100002350530054000453000025907054203440033900480665203127311217190094117804541250232376047621400018101474605000392074982180000215315923100000862035649628002281592662230000026705024813903413100306097770145003752210012808135003941502400105003120922173010600640015400012003100063000560011001304900807404581810000003843817837016460032900060670006720710149103590062559116000071018828300116032901072092342252452641249901370600000022407500007491152011200000002816000580690108457015600570000011301073700005119801240172000024
SP61Bacteria;Firmicutes;Bacilli;Bacillales;Staphylococcaceae;Gemella;sanguinis000000000000000000000000000000000000000000000087000000000170000000000666500000000000000800000000000900000000000000000000000000000043000000000000000085000000003100000000000000000000000000000002200410000000000000000009700000000000001630000063000000001220000000000000000000049000000000000000000000000000000000000000000000000000000000000000000984100000096000000000000000000000000000017000000000000017000000000000000000000000000033700000000000000000145000000015000000000000000000000000000000006300000028000000070000000107000088001540000000000250000000000000000000650000000000000000000000000005200000000000000350067100000000210000001260000000000000000000029000000000065000000000004000000045000069000000000000000000002300000060000000000000
SP62Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT17501093200000027201000000016029002090001640000009801570000019315806203051122511160000000008418165621110017360168001571200000023400000000004161560000001615157492530003115124500294115330394500001510034463158035013004700021513900000001330019201520171156001450000112127283037000016001736903819002880788120273000055081000000307174000926000017500000005741824800131000022018703700441192162001360813000067000018589040124725922025500843460800250011902440083926800011031800152503530007826000102860005451412101880990005600000000095510047057133003001630005102736300084001280000720000080298000000082075320000000150000100228233221117014334393000001322043255007101120000000057071050609513701490000000032000000018400106202014200002754830222172000032015580001212000048450021060002890000142010072020010151684439012973203627890136916300360721602916826660047000960870301003246061970003113500302005110000131440005033029424200016200018000490000052033651232443210595846444950175640001226702800146901741082877082000530292100058108000008938013063212013741422900390210787000150307000035700232430000018200219124143361291606160000590013390100100
SP63Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Treponemataceae;Treponema;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
SP64Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;gordonii0156019700470012165000320012616100005847058023400162196005319066190055018600067080017010614040800653105090274243004905173170428580003151870213097016508300002531416818021922900830136114961703733981864261950290414220023339002020157119028358911601770032500060311000661400260019402480003062875650130879064000052114592000078000150056301321061120402000178020000042400188191104160478493170000006400015001001408290000415040211302730000206436400000005670832074900002661036180098302514533901810077415200207118010080089200015106999813620021400000042200334000116540015500168004991100000163021399000010832801160094800298107901687035503579600688000016570277109000012601480003220001612010129904400085840600000154125824300018000015240381770004201140326729000000047351001643074900000986290003220003740000020002744845290370126205000000007612562954890115402550256103037904022115715018311057278099024667810174110905797621854949966022650304807118505220870249104081087714411985084802800001411638400175366154000000021711322618914000000496909710617117089283200614014755117290167001452197396001064420538422430130965857113400109694510117119002740383500242077012200010230065950553901156220012940279274901143990000023289016800664238214138804060353008204321571129159066003150145293131100597243153000072893004170636851290137700
SP65Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT3140500000000003300000073250103002940000009862420000000000509609700073000000000123000000004800000005100030008401500000000000001440000000000000000000000000000000000000000000000000019800000000000250000004475000000000000000000000000000000000000000000000000000000000001684100000116002440013201430193011700268000028800004200006900000000013300000000070039419000000038580236063000000618528000000000000001240000920000171017801400160000000000000000209000093000007900000000035003530000000190000013421800000121016100000000000000000000019600000024700000149000000000000800000000470000000000000000000002400000000003700032000001310205001340000000000000000620000001620000006000000000000034000000000000000000000028400000440000783200002154000000002300000046000028030400078560000000000000000000001150000000000000000000006393016600480000000034
SP66Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;chosunense000000000000000000000000000001600000000000000000000004000000000000000121000000000000000000000000000000000000000000910000008900022000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000180000000000000000000000000000000000000000000000000510000000001142060000000000000585000000680000000000000000000000000000000000000000001700000000043000000000000000000000000000000000000000000000000410000000000320000000030700250000000000000000000410000000000000011100000000000006600000000000000000000000000000000000003200000000000160000000000000000000000004900000000000013000000000000000000000000000000000019000000000000000000000000000000000000295000000000000000000
SP67Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;concisus00022057320000054000010000140000569313502697280670300000002700670000000000000000001600853100000001930000000016180000033045006565001374704260052001088400031851091070008700008420000588702400001580162500000000950490580000215900001640000032001132101091400848491970001280690000006600310013000000000000370000000370000013615108282000000000970000029000400000850009500005304105013600016400005808712700000000001110120166000000000006200000780135000000000000560000000500000000000821010000000325105700000530000007009700122149000000000001490870002230000559400000148000000000000012300000000947918886055000000000000000002400054001806700059000000390780016009755035014733204400000044000134010100110062000270091000005300000000054015606056003200310006300002800000002000001080360074436904900160000061006853000830066009900000001409887856197895000118109006801090005400000000000838314000137200000073050063004704342000000010600400870
SP68Bacteria;Actinobacteria;Actinobacteria;Corynebacteriales;Corynebacteriaceae;Corynebacterium;durum000000000000028800065000029213741660042000000000680000000000000160750000000101000000000000000000001580000000000136000000000000018207730000000000036100174000145032000000000000000431000000551500722000000001690000000000008500721750075000000000000084000000001980000003230000000000000002890127002850004890000000000000237136000000000173000072901305560000087000000021100014100000000000928011300000000000000000000000000000000013000179000000283000000000000267000000000000000000000000000000000000950000000000000000000007200001100000020901230000000783000043000000001060105000000000000177000000102326500000001190000402250000059000591210000000007100000052700000053000000087000000111000000008904900000984400032100000260000006720703506308902500000014600005907752000195002180007200008901209200590091053173039000000117288066000000184024150000983000000000062440000043013100014607900
SP69Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT17000139000001510000000016100000004600000000173000600000055044072000000000001831240000017049000000061000001960000004002707800005000002060000200001190900227000090014700980015900000001200000000000000000000000000000141006500073700000014501300082000000000000003300000015500000000000000000961540107001830453240000000000000171000123000022200267001350000003616601310000002370000014100000000001122370009600000015400000000000000011800011500225000001354500000001210000023300000000510083000000245002053500000004251010163000000000000001900000000000000049081000027338236300000360275000006401965100000183000000008806500008454320000260000000019101850000129075003281800000031101310000490000000540043713200000025800001810003004200410970716000007870128000000440111450289121000000440052502000967390202600000000100129490073000007951501590016401930980016709800020073280000000111640382013400370000087250179001140000147001870003439102100460850000008005100
SP7Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;sp. HMT3800110000000000044000000000000000000000000000000000000000220000000000210000000000550000000096000000000109420460000000000000000000000000000005300000059270000000000000000000000000123000068006700000000000000000000000000000036000000000000680000000000062000196054000000011000000048000000000320000015183002800005800600000000000000000000000197075000000800002010000006400004900000000000000005200000001010190213000000003200000086000000000002192376200005300102010100000012800000000013600000003000096092021959000000000009406400000000000000000480024002800000046000000059000000003649000021006400000068000056000000000850410950036000000000002800000000000000049000000001180000000000000000000050650380000005209131000830103006207402031000000390071000000000000000000000000001800000000000420000000005205700000088000
SP70Bacteria;Spirochaetes;Spirochaetia;Spirochaetales;Spirochaetaceae;Treponema;sp. HMT237110000500017414500670027005503400000000004600001100000000312011300000000000820000000110027009001230000000000004500000000500053000000400103000041000681600187770000000000071000023344000720000000000091000009800000095004200000000536900000000000073000280000000000027029000460005015100000000000000017019600000214929215400011500047000001469700152760000158006101670000000000431970104000001800007103620000000000082000000014401376600025200000190030130276019078078108000111000104000240030802480003070000022115900000000000751390000012500029024900000016700000072012900000002930000000000120000750000000001500133000210000350000002700000340006839002000000000000170713000007000603700161170001450500910004800008600000000008600590091000002300000000000002500001908602100000048000000098430671110000003300000000000000000000009101030000356600800520000000000000290000730005400000000001505003013418001054000054
SP71Bacteria;Firmicutes;Clostridia;Eubacteriales;Peptostreptococcaceae;Peptoanaerobacter;[Eubacterium] yurii000000000000000000000000370000019000000791800000000000000000000000000000000120000000000000000000000000005000000000000000000000022000085000000000000000000000000000620000000000000000000000000000000000000004600000000000000000000000000000000000010200000000000000014000000000000059000000000022413301180000000000000000000144000000000000000000000000000440000000000000000000056000000000032000000000000000000000000000000000000000870000000000000000044000000000005703690000000000000000000000000000000000000083000001200000000000000000000000046000000950061000000000023000700000000000070032000000000000000096000000000000000000000000015219000000000000000000490000066000000000000000000000000000006600000000000481870000000000000000000046000000000000000
SP72Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XIII];Parvimonas;sp._Oral_Taxon_11015115000001300000007900016000000001190000149000001200024000000000000000000000000800000000000000000000000000005550000000000000270320070000000011100390440000021009100000000000000003700000000211000000000009000430003950000000000000000039060000001030000000178370000000000000152028628151000128000000027600000083091001200000000013800750100000000000000000000390012600457200000010900000000000000000007322200002100000000000000063300000169000000000000510000000000007541400000060000000000000000000007200000040000000082000000000037004400000003920000001236059000000530170009401100000015500000000086139002120005800000002700000019102120000099720000000005800000850000061300000049000000000005302912578000017400000053020000000000000000000186000000000022003600000011700019000880119000004100190000000940012164000000000000044730044000007100000000
SP73Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT5252882110002397101591350563880000000086002390000002479401412060128000850000014301750115025301861372370760259000048005030118031139817600000000000021758013800000186035523400000002031290883854070024203183761210190000043700000019529500021400001000016425000000000000266001162160010994440023700000000000000000204000001558212202390000000022735900000191000031600000000000000000029806110000000015200204030144200000000000000000000000000000002878400000000000000000000005110000000000000001380000000000000000000000000004730013200000000000000000000002090014200006000016700412000088000090000061004710000702000000000000000000000000132000000000002200002222490024933000000007002160000470000021900000043000000003190310000016708545620081002260123123124750001610025300000106010200088046381380000000011100006100000000000222000011006700000000068000000001750170000060000000004020000000038001430000000000004401030000002164300000000104000901011490950000126000
SP74Bacteria;Spirochaetes;Spirochaetes;Spirochaetales;Spirochaetaceae;Treponema;vincentii0000000000000000000000000000000000000000000000000000000004600000000000000000000000000000000000014000000000000000000000000000056000000000000000000000002700025000000000520000000150000000000000002900000000000000000000000000000000000000000000028100000000770000000000000000000000000000000000000000000000000010000000440000000000000000000005000000000000000000098000000000000000127000000000000000000000000000000380000000021020700001590000000000000069003300000000000000000000000000000000000000000000000000000000000000000000000000615400370000000014000000000000000000000000000000006000004500083000000000000000000000000000000015000810000000000000045000000000000000000000000000000000000000004600000000250000000000002400530283300000000
SP75Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Stomatobaculum;sp. HMT097000000000000000000006500000000088000000000000000000013000000000000000000000000000001130005200000000000000000000070000000000760000000000000000000000000009700000000000000000000000000000000000000000000000000000000000000420000000000000000000000000000011200000000000000000000000000000000000000000000010000000000000000000000006895000000000000000000000000009408900000000000000185000002520000000029406000000000000000022711400000000000000000000000000000000000000000073000000000000000000000000000000000005200000000000000000080000000070000000000000000000000000000000000000000033000045000000000000000000000000000000000000000000770000000000005200000000000000000022003500000000000030000048000000000000000000000000000000000000000000000000
SP76Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._Oral_Taxon_8480000003540000000000000000000730000000000006230000002830000001480000001970083010200016600118000285000290000000000006500000850000000001360000000135000000000045000000000000003450000000010500000000000001090000000000101007600630858118009100005000033552043100000000000035000000001170000000000000000000000000000007900000000031100000236000000000001817000001982680000000000000000000003220000886000000001360023300000000000000013900000000000101657000000760000000000000000389000000000000000000021200000000000000000000000000014390000000000049900000000008600540035500000000000012004376000018000006000000002504500000000000000002000000010300000109000000000000017400023931000010700248003300014124000000020860000000000000034000052008100000000000560005890011300116000001250000000006890000000069001127000000000000000398000000070000000000000150000
SP77Bacteria;Firmicutes;Bacilli;Lactobacillales;Lactobacillaceae;Lactobacillus;ultunensis00000000000000000000000000000000000061000000000000000000000000000000000000000000000000000075000000000000000000000000000000000000000000000000000000000000000000000000000000086000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013000000000000000000000000000000000000000000000000000000000000000000015200000000000000000000000000000000000000000000000000000000007300000000000000000000000000000000000000000000000000000000000003800000000000000000000000000000000000000000000000000000000001820000000000000000000001900000000000000000021000000000000000000000000000000000000000000000000000000000000000000000000000000005500000000000000000000000000000000000
SP79Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;melaninogenica0000077003100000000000000000047010610970186100520000001040000046000000000142000068000000000001090012510400900310000053338907800000000043060018346000039212000000024000000420127380003626307100000005905514000000045000000000000012700011200070000000000670146970000093009904323200001100000930000000000000028219500004500000000103000000190880030003790000000000129488000741310002111801160000024000001044700371000133123900000157000008702037550440000008300000216740000000000000000000000005101780000000025600093009694024500160002190183000000016100000082167012000014600017300000000001870178000000016201190018808900190072000011210100000967800003800000000910072000000045900001700090011600132000009400000010201760000000000000000015330286000980020500470011115803122000690000000112000000000000006300000141011400006006736362361000000000141017259000000949280005400000560000000069000011500000000006100065003800083000360300001049
SP8Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;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
SP80Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp. HMT3920000000015570000000000000066001170000000000000000000000000730000000000000000000000000000000000000000000000071000000000000000000000350000000000137000000000000000094004800000000000000000332600000000000000161000000000000000000000000000005100000000000000000000003620000000006400107000000000500075000001000000000000000002032000029200000000000000000040000000000000000000000000000000000021200007300000000000000000000000000000005100008900000000290010000000010700000010900000000000001050000000000000067000000000000000000000012300004100560000000000000000000000135000000850000165000039490000000001640039000000000090000000000000000000000000000000001200000003202730000008500080000000137000000000000071000000000000000000000000000000000000000000000000000012700860250000085
SP82Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_ss_polymorphum000160000934200026200012525300019328129009076029108755656200019100000920000000023900097490012900001870010702091590064010800006800150000000200000000011500000133071017200001341033400284044002060542000115160116172146005466000001180000224281451250000001543230112130018001180010624311584602740006300470001960000840709715700000000940000118000010400000001500003740123105403016300002920000000001017245013643800000000325000010202561361153623860022200000025325600830000218000006198001252150000000134000366021804142400000000026500006212811700000000065900002710037000211000022700000000000000001843217600000132010500145283000003680122002430000000000001850643060204000001760000002012660000006200000000204000041411311015413000796012400001930192000400600000000011817016900017831028600230001664426301246400008020329268019302846200210493220426800601435001960179077000691170176025300000014400360000000000002146800179001161771550242033004565001963360540016610128002260068660126187239032000127109003926000000000172057000231610124084204000081000820000000054590291307003050201014006629837
SP83Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-3];bacterium HMT3650000000000006800000000000000000000000000000000000000000026000000000000000000000510000000000010000000036014374000000060940000000000009500000000000000008500001350000000000000000000000000000000004141000000000000000000000032000000003020280000000079120000000000000000208000000016400000000000000000000000000000000003700000000001140010800000000047000000000000930000000000000000000001800015000000000007800000127013000000000000000002340000000000000001930181000000000000000001210000000000090000041000000000053000000000002330000000017300000000025661700130000000000620000000000880000000003600320000000000022000000002250000000000000082200000120000000000000000000001100030070000000000000000000000000000000000000000000730000000000000000008200042000000000000000000015100000
SP84Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_ss_animalis231331003752100579216146342181010102060223550023900479175032700004171241772550177390271000124102273024860173019602490198532227547900442028832600021300090940123030100000178542350030116739101300226191506500068002540146029591028064217754020036664112617039000245025910519700026217722100309177264352460194027900177260127001550227038000488433103853030617972561190061000151185048055002530000019101432042012742080160034707814370002426143915612517900185617000000242014602211323000254226128400018752501794601340158235034800676003250542017907350104302040155123137026376201000094704067371310552000511025013492960002770942128200119055000713157014393540201761399836547021504340152503392113622807700000000067503510699104029005510530004072802637531940131863001713284090053125400001611235014731202017581131189328300035123916224400129804044600196055331800060412703820000303302019925801533890211805483470130806501117010400000694848000000002212205432082460144680301066884459938203500004293907721215301950137515021102711912533620931019803017382262113187822976119439876080190196052102250497042723196140640400484006465064400005292991280017514305260198002201189615337336720622630883142006640212572267241709038819564800146188175406250001914330860264029844306238842040558038300000042045915917440403332573428503364815100050000378469200699296428105102581143093671960009111710404450427519021828508418112721439179695455347206001221346301392732091132382963781503590166051303980
SP85Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;Coriobacteriaceae;Cryptobacterium;curtum000098000000000140000001370000000000000000015900000000011400004319500000000000000600000000000300000000000000000145000000000196000055000000000000000006700000000000000000000000000201000000000079810000000000000064000000000000000000161700000001200590000000000000000000000000000000024600000000000000000000000000000000020200000000000340000000000000000000000000000000000000000000280000000159000000012500000002300003400000000000000000000000000000000000000000000000000000000043400000000000000000000000000000000043000005000000000000000000001030000004000000010300000000000000000009104202600000000000000000000063000000000000000000135000000000078000000000000000000000000000000000000000000000003400000000000000000000000000430000000005900000000000460000000
SP86Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];bacterium HMT3490000027600119250874400000036564200000133000000680009700000119940004300000239014417115600001239399007700029097095109000000015800260106000000000000000042000000000721540009900000000012165400000970000000147002100030100020100201001391570000000000160098000000000007400000113000080000190000410000600000029201140005001767300000002970193000182014803600539000000000000000000260000470003560001390000003870520000000000128032031500302000903430000015826800000000000088139920015300019701271140000008408401350127417000000617364000002390000000000006930490825000432471019500000164007529200085000003390375103990257018500180030302650000015700000000240074005500937702750900000106780002400012175002250000012900000000344623204677494000000077001120000970780193000172290065006000068004000580890047119021001286000003100000004915201113617701070000299000013625003330331315000165000000004420022244000006500094006300000008448500010100000000740560012300001824182253475167000000000820010314536347089580001240
SP87Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;infantis0000000000000000000000000000000001100005700000000000002600000000000000000000000000000433580000007000162149000001370015100000000000000000000018018000000000000000630000000000000000000089000000144000110000000700000000000000000000077641020000210000000419000000400000000210800000000000000000000000000000000000107640000048012000000000000033000000000000029303400000000000000000005400000000000000000021000000000730000000000000000000620000000000000000000000000000080630000000460000000000000000000250001300000000100000450045000000142000000077000000144000007600560019000000000000000000000000000000740000000000000000000000031002400000038000136000610000000000009200006900000000000000000001100000000002700000001900000250009000000001040000000003600000070280000000000000000200
SP88Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Veillonella;parvula49762113762608439412299201233483130239599910376895032871106153081106566314621736345142384512290498192310112116811184963750127158416344845654239844719704551385924027668615231882794988466724024511024108933046045920122285367489292185126977035876781647517430507348545341699754301158619561018661488516942883727062861795258495945900560439111512211410487349902306025256581081381705036513013300292589068516414321215356503001096617067725669899770013502941102510550406110032512543848258956739127442003891412240215153138132888137105347177521092020124200112111357257742122810631865810127929960231411108308832390165132305364666501015279210423607532661099689788119419759643404572117825914292660028003044571046105819404020404686129808778033417307788611626681657119815597371521646375583126883321559020020165407196447762421722586313757180914678613342071194448568120010529910279894691017383931130237497418917846664966220102387030414762241683438702495477350291004177517964543989941979946136432231412774396113413912160257162040036584362916267082482127238240614171250137716184917351834340632183078013031034607882774101522048911490793161069342237472378518001121494115412741287105558014982261051841889159187559015321362145285501944537490533454386683615611031195454167929301666496307236956148689214451567104290343310123762101152860238019426513027952521016485309971063102701491621040628116614472152881394107887759120023252589019663893837430635955546784554231860334206188494615723711891224564970131214022989322254942621580111215201130505237681963816281039653753743024464136092055051651120329525413623696736284146328749450952339878673540805625114194366174610919092117719864811027552051429893241231084082056645216085954671414248182404469715437356357953371160697662100291928731138513120595670404621813231306108162544306132411713184661191473887204260457956888541419541173581928117254413722852321077386943865033577757922616841256186159326517696108931060357715050057949724460122944271526143049928840661237735101577810214202642197853596754850110383269350691547111362700293711103362
SP89Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Leptotrichiaceae;Leptotrichia;sp._Oral_Taxon_B570000000013000104000098000000000000000000000360000127000000000000011800000001290000000000000000000000000000000840000000000000000000000000000000000012801060001230000000000000048000000260000000000000000079000000000000000000000000000000000000000000000000165000000000004020000000000000000000008400376000000000000000000000000000000000385000000000000190000000030800000000000000000048300000000000000000000000000000000000000000600000002210236000850000000000001430800000005570000000000000000147000000000000000000000000000000000000000000000000000000000000000126000000000000000000000000000000000000000000510000000000000000000000000000000000000000000000000000000000069560000000000000000000000089000000000000000000000000690000000000000000000169000000067129
SP9Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oulorum00000870692900000002601779448300010910800073000437903317227000000000920000000020100091044220000000000696000000000610000062160022300001480000000000058520019467052000000000035000000006182000044000177800390000560017427000001471180000015500000090083006211400742190320001090551050730000000000640940000000000018502202390657900000172024970008500830021200020901180131000340000000000000023517600000001200000000085143001242640000014609231095008113361000000800000000001410000000000042700048000000008700000044000007502222861801550090065275002030000110230000000016580002690900068121235000117000000049110890066001760144761530671620650720031700000120064000000570000074000000290644500008398470150000019670000000060000405200058880067000580114001000002300001305313900004303703400062061000000000230008500000000000000400000074109163660000550134127005200340061507836000970000009216908904500104073000001000052000330002107200510770000000044240000030098000
SP90Bacteria;Proteobacteria;Epsilonproteobacteria;Campylobacterales;Campylobacteraceae;Campylobacter;rectus0000000000010000000000000000000000000000000000240000000000000000000052000000000000000000000000000000000000000000000000000002504000000000000000003000000000000000000000000007300000000000000002700000000000000000000000000000000000000000000000000000013410000000000000000000000000000000000000000000000000000000000300247000000000000000072000000000000000000000000000000000000000284200000000000000000000000000000000000006600000000000000000000008500000000000000000000000000000000000000000000000000000000000000000000000000000000490000000000000000000000000350000000000420000000000000000000000000000000000000000000006800060000000000000000000000000000000000000000000000000000000000000000000000000000000000000034000000000
SP91Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Schaalia;georgiae000000000010716000000000000000000000000000000000000000000000000000000000000000000000000000000000001340000000000000560000910000075000000010454000043000000000000000000000000006173000000009700000001508300009600000000000000012200000000000000000000000000000000133000000086000000000000000000000000108000000000000000027000000005000000000000000000000000000005000000000000000600000000001140000000000000000000252000000026900000042522430000000000000000000000000000270000000000007700017400000000007900550000000000000000760000000000000000000000000001670000003700000000000000003400051000000000000008500000000000000008900005700125000009700000000000000000000003000000000000000009400072000000000000000011346000000000000000000004904400000000000000000000000000000000
SP92Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Megasphaera;micronuciformis000000000000000036000113000000000003707700180005000000000000000000000000000000000000000000000032000084000000002120000138800000000000003000159000143000870000660054000012600000000000000005000000010200000003000008609300000000031000180023002900000009100000950000160000000000086357000000001500000000540000000000002500019200173001770000840006800000006300000000000000000017000690000000000000000000000000000000000000000140000000139054000000000016701430022100330054100116000001750000000000810000000000032700000018608000003260245000000001530182001370000000000000000000000000000105010300000015200002815161014700000003521000053000000000000000000000630000000000000000400092170220000000000330000000000000670750000098880320000008000000000000110000010809500000002680630490000410000000000000000010700000000052000000000000155000000
SP93Bacteria;Firmicutes;Clostridia;Eubacteriales;Eubacteriaceae;Pseudoramibacter;alactolyticus00000230000000000000012800000000006300057000000000000000000000000000000000640006000000000000000000000000690210000000000000000000000000000000000000000011000008402800000000000000000000000000000000000000000700000000000000000000000000000000000000000000001070000000000106000000000000000000000061000000000000003200000000000000098000110000000000000006200000099000000000003890000000000000328000003000053962500000000000000000000033600000144002850000463014400800000000000000000000001450000000000000000000000000000000000000330000000000026000000000000000000000000000000000000570000000000046000000710019000000004400000000850000000000000000000000002900000170000001000015000000000012000000000000000000000000000000000000000000004909900000000000000000000065000
SP94Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;intermedius1457057290109571140198000109126000000587216264116000125071000420050001520013000040101960027410034959780061900149570096000017196630056003538400097894679000128156306900000778700330002145624174967001248000000347580062000105000033244144000000000213001190000006800650183002711670000650004221221300110000000963932013440047231121030961222001812183853269307117879600403590000631400533395000059000110006220070129700790149037500235043598576112890000268000000008618813079500015000115460132164007348202851840000001150003497112004050000207600854440898121828900259124322415801120000328000000956006613016800338000000088002100488066200093964200046000113550246003031202000003000000247062066100000088100184046000002521510005560318098001040000013490000213016264883921909191760034510123147018321519230062219704318049032046002101505000081495783330109002561140640186000334010983011200770575160284727608179032191000720253010606004114830600911571954607700158159702446103536313091159409591550191889021867000124001307200009016043264450000054032240000205119000001634900042086007500001141261792570197202981099530190023280001780162270552001710048000201002807540031022250000743550140000013700
SP95Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT897000000002690001493700000000003520017100702080131960001410000028500005500000171000570000001340000000200000295000000000127000001043001260342000000000000108000000000000001790000800280650142881070000000034206372460029800026200236002693290007414600120290017602020013100000000251180000001444300000000000010500000000000000025504580000000015702950000000000000000000000014600021325700000000000000001760052400019900000000002550000000000000000198000000000000063400035000044200387002099040000000033911720000000000000000994000000000768028500000000000035600029969000000000000014775640035400002060052100000004510000002740000003500003329300000260000860000115000000108002900000000000123211007400000000000001146960022100060001000001500000000000000000300263840000037000000000000006800002260001262170760029200019614468067000001951320015395009400090006200660000000011447000000000001301063400780000040159000000000000143000197183206840003140154111
SP96Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;sp._Oral_Taxon_137000000000000000000000000000380000000000000000000000000000000000000000000390000000000000000000000000000000000000000000000000008300000000000000009400000001310000000000000000000000007600000000000000000000000000000000000000000000000000000000097000000000000000000015100000011242000000007300000630000000000000000000000000150000000000000000000000000000000000000099000000006300000000000000000000000000000000000000000000000000000000153000000001230000000000000000000006700108000000000000000000000000000000000000000000000000000000000031002800000037002300000000200000120007600010000000000000000000000000000000000000000000006500000000320032130000063000000000000000000000000000000000000000000000000000054000000000000000000000000024037000000
SP97Bacteria;Firmicutes;Clostridia;Clostridiales;Lachnospiraceae_[XIV];Lachnospiraceae_[G-3];bacterium HMT100000000005200001870000560000510000006300000006500000000000000640001280006200003800000000002000000000310000000800000000000000000000000092008901220000000000024000000000000004758022650000000000000000000104047000000000001350430000000820001800000000001900000000000028000189104135022305700010214000000000000029395000000008343700000000240111000000000000041000002620000000000000000001390000000030600000000000000044011801180000025203600183000000000000000000002290000000147000000017201700000000000000000014600000009008600002110000233840000001174500000072000000000000028067631200000380000000920000830000000009611000580301450000000518100540000012807800030019000085000094120010055000000000000000000000000000000000000000004965000000000085540000052000000000046520360007300003869000000000000000081890720000006600000051000650570786226079000000091
SP98Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;ochracea000000000000078000206200000000000000000003647063000575900000000000715401670000001260001227800000000000050000000000048000000000000067000000066620000000129480000000000660085000000017420000000000000186422000149000000190006836000150000000004000080000016000000000000000000480000000009800000112278144001600000000110000020100005508400055003580028700006578100001970002490761140000000000000000011512400223304002110000000000000065128000450390001501720000000481300000016394380005200000165000000136010846590000000000000000000106029000000000067008873000029407800000690095000000143000000052870000059010873007400000351500036000000000000000000081000628200000006900000000004100002557000000000250000002723000000420048000000000000000000000000000003859000016300032000000690004425003562134000000000000049029340000064047000000620330000000000000000005000002600094000000
SP99Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XI];Peptostreptococcaceae_[XI][G-9];[Eubacterium]_brachy991610270842319387015201150691470000006439218002485862149279119262210021500000357223198051027150159000492490012401677230780470133135610803092053601805045130270160007412100015907006800003100910210000011707200258232018100008142400008521809129514303113010800006701100008308300130677600941003561292142115200134142002542480000010700192060010323103000181000000270018000000211000109132060000303024700237431200245529000002700001410025046300049717911215752571570013115200019900001330430000890000120387010722642000142610066401630103000369709411132441800306008800106032526411370398849831802500063820012700000022769136133045077000550001773930284089101672051041690000821787000000004063757236000198011700002682780485917517001720001902356308480025800273000360134267027300000748332701900002830753034600368018415102560015011516091002521610281200082057119273000003090121012026571442924887150487948283146130094611118461534110103423620807320546401565770440272022008835740038825027015214501500090022190111000017208206151255000020001308200156801420661952500101530134121208830411665209346012147001284766892202257154057001145920150000000633801112401183830640044001438113143011610160002111050401513400000621626145110815225910124542398045000
SPN107Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Leptotrichiaceae;Leptotrichia;wadei_nov_97.395%00000000000000000000000000000000000330000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000920000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000710000000000000074000000000000000000000000000000000000000000000000029400000000000000000000000000000000000000000000000000176000000000000000000000869100000000002100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000140031000000000000000000000000000000000000000000000000000000000000000000000000090000000042000
SPN109Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._Oral_Taxon_171_nov_97.974%821660014400000000000000524000009900000000035814008800032000000001670000193000005610530001030109000000000911630000000000000030800000000000143000940610010109200000501000000000056025002910000154000000000193066651000101000007297600000000000000000000009222608300000001950000000000008601818300119000000000640000000000000003900000000000000000000000000000000000001810000780000000000000000000000000000000000000000075000000000000000000000000000000000660000000000000000000000000000620000000000000001400278000000000000000000000000000000000003740000000142000000000006160001048000179080700000533011032009904100000908000020000000800992380000620000020300000000000000000000016230141000227000343000000053809114201320016400072700000000000000012600002760117000000000000000000000000000041500124000000000000026400000000214002170007236000018400000414000188000
SPN129Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;viscosus_nov_95.849%000000890000000000000000008100000050568013102903280168000110959400000000001732901490000003900001230000102000000000630004223000074900048011300000000670000001160000280009405760000003070033046000000000000000000000300000000000020000058020648000000108015606905070000000000001131161008677446000000012000000000810000000000156000000000000000650000000000001880120085300000135000063300015100000000840000000000000638000000469077002570000295000000000000008050000000020100000000000000000000000000960000000030500075000000000000000000000000000020308310000000000050540000000000473130118515000099000000184007203360049173000000020400590000169160000004374600000077506100095050027000000450000000059000000000020000018500000000139136000759000001425000000750140020000031002600000001420280010600008010000000093000008501120000013801110012000000003705300098000004300000000100610000086280006500
SPN13Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp. HMT175 nov_97.633%00000442112250019000001272390000000000000000036000015300000000000114063000007100007200134000000174749900012000000000015020800254082059500016120701900050300001330004600000006500000000010000000000152000000001230119487903900000000000000011912203633800005000123000000000040630810000005500080011302547300000001220000000000000000000677600657000000003391300535070075000000309000013602051500000000000000021800000510000074300000000000000092004630006691550000195000890000284001300397740460178000189000000000001360000000000000810013100000000000000000000000009217300000099000000000000486530097000151000670000000941127000001403400007026001080027000070004200000000000000000710004400000610035169000000121063000000001510000001130107025000000102480154000014600572074013600007314300000000000000005600560000004800000001720000000000410000001915900000003300167312054002700002821131830780000010100000000000000096066003200
SPN131Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;veroralis_nov_97.538%0000000000000000004500000000000000000000000000000000000000000000000000000000000000670000000000000000000000000000000000000000000000000000000000000000000000000000000000000054000000000000000000000000000790000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010800000000000040000000000000000000000000000000000000000000000000000000000000000000000000096000000000000000000000007800000000000000000000037000002200000000000000000000000000000000001200000000000000000000000000000000000000000000000000000000000000880000000000000000000000000000000000000000000000000000000000061000000000000000000000000114000000000000000000000000000000000000000003600000
SPN14Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;loescheii_nov_96.768%00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018200000000000000000000000000000000000000000000094000000000000000000000000000000000000000000000000000002190000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209000000000000000000000000000000000000000000000000000000000011100000000000000540000000000000000000000000000000000000030000000000000000000000013000000000000000000000000000000000000000000001020000000000000000095000000000000000000000000000000000000000000000000000000000000000094000000002840
SPN143Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-3];bacterium HMT365 nov_97.244%00000000000000000000000000000000000000000000000000000250000000000023000000000000000000000000000000000000000000067000000000000000000000000000000000000000000000000000000971000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002270000000000000000284000000000000000000000000000000000000000000000004300000000000000000000000000000100000000000000000000000000000000000000000000000000000000000006400000000000000000000000000000000000000000000000000000000000070000000000000000000000000000000000000000000000000000000000000000000000057000110000000000000600000000000
SPN154Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;dentalis_nov_97.688%00000000000000000000000000000000000000000000164000000000000000000000000000000000000000000000000000000000000000000000002340000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002170000000000000000000000000000000000000000000000000000000000000000000000240000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103000005200000000000000000000000140000000000000000000000000000000000000000000000000000000000890000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SPN162Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Marseilla;massiliensis_nov_78.189%0000000000094000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013000000000024000000000000000000000000000000000570000000000000000000000000000000000000000000000000000000000000000000279000000000000000000000000000000000000000000018900000003560000000000000000001930000000000000000000000000000000000000000000000000000000000000000000000000000046000000000000000000000000000000101000000000000000000000000000000000000000000010500000000000000000000000000000000000000000000000000000000000000107000056000000000000000000000000000000000001060000000000115000000000000000000000000034100000000000000000000000840001110000000000000000000000000000000051000001400000000000
SPN165Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-5];bacterium HMT505 nov_95.992%000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029000024000000000000000000000000000000012000000000000000000000000000000000000000000000000000000000000000180000000000000000004590000000000000000000000000014800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011520000007100000000000000000000000000000000000000000000000000000000000000000000000000000790000000000
SPN177Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;catoniae_nov_97.719%00000000000000000000000000000000000000000000000000000120000000240000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000091000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002370000670000000000000000000000000004900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001590000000000000000000000000000000000000000080000000000000004200000000000000000000000003100000000000000000000000000000000000000000000000000000000000000000000000000000113000000370000000005200000000000000000000000000000000000200000000000000000000000000000000
SPN189Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;mutans_nov_96.858%000000000000000000000000000000000000000000000000000000000000000000000000000000000020000000000000000000000000000000000000000000000000000000000000000015500000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000060800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000096000000000000000000000000000000000000000000000000000000000000000000000000000000000000001060000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SPN2Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;aphrophilus_nov_97.348%00000000000000000000000000000000000000000000000000000000056000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000992000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000130000000000000000000000000000000000000000000000000000000000000000000000000000000000000005650000000000000000000000024000000000000000000000000000000000000000000000000000000000000000000000000
SPN200Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;weissii_nov_94.220%00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001900000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SPN212Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT300 nov_97.239%0000000000000000000032000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003000000000000000480000000000033000000008000000000000000000000000000000370000000000000000000000000000000000000000000000000017000000000760590000000000000000000000000000000000000000000000000058000000000000000000000000000000000000000970000048000000000000360000000000000000000000000000000000000000000000000000000000030000000000000000000000000000000000410000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001200000000000000000000000000000004200000000000000000400000000000000000000000000000000000000000000000000
SPN218Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT300 nov_97.638%00000000000000000031004800006800000037000047000000006800000008700000000000000000570000000000000000034000000000000000000000000000000000000000000031000000000000000000000000000000053000000000000000004100000000000000000000000000000000000000000010600000004400000000000000000000000005400000000007100000000470000000850000000019800073000000000000000000000001260138000000000000000009000650000117000000000000000000000000014500000000000000000000000000000000000000000000001800001040130000001930000000000000000000000000000000000000000000010300240000000000000000000000003600000000051000000028000000380000000530000480000000000000000000092000630000000000000000000000000000003725000000040000000530000000000000000000090000000000000000400000000000000000000
SPN223Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;noxia_nov_96.324%00000000000000000002600000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000210000000000005500000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015300000000000250078000000000000000091000000000000000000000014200000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048000000000001030000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005800000000000000000000000000000007400000000002200000000000000000000000000000000000000000000000000000000000000000000000000000000000
SPN246Bacteria;Actinobacteria;Actinobacteria;Actinomycetales;Actinomycetaceae;Actinomyces;sp._str._ChDCB197_nov_96.023%000000220000000000000000000511000000000000151000000660000000001010088014100000000370000000290730000000000036000003410600000000000000780011400747910000000000630260000000000000000840000000005400130000000000000011779130000313720000000054000001470021000002800033000163010500000002630000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000470000000000000000000000000000000000000000000000000000000000000000000000000000000078030000000000000059022100015200000001390000000845300900012615000000000000000600830000000450040000023841000000047011000109031000003401010002700000024667000000001470000000064000000000005100183000000000000000010000000044027000010320000000061000000008400000000890000000251600000
SPN26Bacteria;Firmicutes;Negativicutes;Selenomonadales;Selenomonadaceae;Selenomonas;sp. HMT136 nov_97.917%000003000000000000000000000000027000000000000000000250000016001010000029000000000000000000000000000000000000000000000000000000000000000000003600000000000055000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000820000000000064162000680000000000000000061000000000000000000000000000000000000000001510000000000000000000000000000001230000000001300000000000000600000000000000000000000000011300000000000000000000000000000000000000000000000000000000012000000000000000000000000000000000000000000000000000000002400000000000000000000000000000000000000000000000000000002700000000023007200000000000000000000000000000000000000000000000000000000000000000000
SPN282Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_95.046%0000000000000011000000000000000000097000000000000000000000000000000000000000000000000000000970000000000000000000087000019500000000000000000730000006900000000000059000000000000000000000001130000000000000000000000000000000000000000000000000000000000000000002700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010100000000000000000005000000000370000000000000000000000000000000000000000000890000000000000000000000000018900000000000000000014100000000000000000000000000000000112000000000000000000000000000000000000000000
SPN353Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_97.037%0000014500000000000000000018000520013600350081000000011600390194000000002475000000000073000025000119000000000272170000480000000000000000056000006700022600002030000119010100710024200000000031076008900000000000000004300002090014000930000000000000000000000000000000000000000000003800000000000000001160000000293000000000000000000000000000000000000000000001910000000000000000000000000000000000000020100000000000000000000000016800000000008400000000000000000000000110000000000000000000000000014400000000000000000000000000000000000001140105000088000000000000001190000000000000054000000000000000064000069000000126046001250000159000000000000000132000000005900000000000241000011100000015200118000811241120670141000000000005300960000005500000000560007000000000000000000001900000000000000000140000025010800100
SPN38Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;infelix_nov_97.248%0000025000005000000000000000000000480000000000000000000030000000000000000000000000000000900000000000000000000000000000000009000000000000000058000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001210000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008600000000000000000000000000002390000000000037000001060002410000780000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000320000000000000000000000000000000000000000000000000000000000000000000000000000004200000370000000000000000000000000000370000000000000000000000000024000000000000380000000000000058000000000
SPN399Bacteria;Bacteroidetes;Flavobacteria;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;gingivalis_nov_97.665%000000000000000004100002300000000000000000000000000000000000000000000000000000000000530000000000000000000000000000000000000000000000000000000000000000000037000270000000000000000025000000000000000122000000027000000000000000000000000000000000000000000000000280000000000000000000079052000014300076000021000001611050000000000000000000000000000000000000000000000022200000000000000000000000000000000000000000000000000000000000000000000000000000000013800019000000000000000000009400000000000000000000000000000000000000000000000550000000000000000000000000000001490000000000000000000000000000000000000000000000000000000000000000211060000000000000000001050003900043000000000012300000000000000000000035000000000000000114000000000000000
SPN43Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oris_nov_95.833%000000000000000000000069057500000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005000000000000000000000000000460000000000047000000000000000000000000000000000000000000000000000000000000000000000720000000000000000000000000000000000000011400000000000000000000000000000000000000000000000000007390000000000000000000000000000005800000000000000000000000000000000000000000000850000000000000000000000000001850000000000000000000000000000000000000000000000000000000000000000000000000009700000000000000000158000012025100000000000000000000000000000000000000000000000000000000000000000430000000000000000050700000000000000000000000000000000000000000000000000000000000000000013000
SPN464Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;veroralis_nov_97.348%00000000087000042004806704000200000000000000000000000000065000000000055000000009000000000000000000000010300411600000000000000000017100000000000008000000000000000000000000007900000056000000000008000000000000000000000000000000000000001700000000000101830000000055000151001680190002530490000001650000000510173000001761110002700010300000000010800000000002763800000000002030000000009700000000000000117000104001820001368900000000000000000150000113000000005140000830008600003000000036000000000000145000028500000000000000000000000000000000000410000000001016000000000000000000002800000058054000260034000000000000007200000000000000000000000000000000000088000000000050000000004200000057000000000000000011100047000045000400000000000000000000000000000000110000059000000001180002000013000000
SPN49Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;oulorum_nov_90.019%0000000000000000000000000000000000000000000000000000000000000000000000000000000003400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000091000000000000000000000000000000000000000000000000000000000000000000000016200000000000000000000000000000000000000000000000000000000000000000000000000000000000083700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001700000079000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SPN517Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Porphyromonadaceae;Porphyromonas;sp. HMT284 nov_97.633%0000000000000000000000000000000000000000000000000000028000250000000000000000000000000000000000000000000000000000000000000001900000000000022000000000000000000027000000000000000000000000000000000114000000000028000000000000000000000000006200000000000006900000017700000000000000000000000000000000000000000000000000770000920000000000000000000000000000000000000000000011200001190000000000000000000010300000000000000085000000000000000000012800000000000000000000000000022300000001180000000000000000000000000000000000014000000000000000000001060000000590000003000000000000010000000000000000000000000000000000000000000000000260000001030000000026000000620000000000000000000000049000000000000000000075000000000000000000023000000000000051
SPN522Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_96.679%000000000000014700000000023400000000000000259000000000000000000007400000142000000000490000000000008500000000000000000810000000000000000000000000007700000960000000000000115000000000235000000000005000000096000000000000000001000000000000000000000000000000000000000000000000000000000000001510000000000000000000000000000000000000000011700000000000000002530000000000000000000000000000000000000000000000000000000001670042100010800000000186244000000000002020000000000000000000000000000000000000000000000000000000000003900000001210000000000000000008634011500000000000013201660000025560011800000000000000000008600000000013300000001790000000000000000000000000000000006000000024900186000000066000000000000000000000000000000004700000010800000000000011100000000000000
SPN534Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Marseilla;massiliensis_nov_77.473%00000000000000000000000000000000000001880000000000000000000000000003100000000011600000000000000000000000540000000018000310460000000000000000000201410003400000000770000000000000000278000065000000030000000000000000000000000000000000000000000001700000038400000000000000000000000000000000000350000000000000000700000000000000075000000000004800000000000000000000000000000000000000000000000000000000000000000000000000000000000000023700000000000000000000000000000000306000000000000000165000000000000000183000590000000000000000151013100000001600039007700000028000001100000000030800039000000000000000000000057000013900000000000000001400410000000000000400020900054000000000001420000000000217008100000000000000000000000000000000000000000000059000008500000385000
SPN547Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;nucleatum_ss_animalis_nov_97.416%73790000000000000000000000000000000000002700000000006800000000000000000000000000000007000000085000000000000000000000460702100000000000000000000000000000000000000000000000004400000000000300000000500000008000000000000000000055000000000000000000000000000000000000000074015005500000000000194010400000000000840000001800000000000310000000140000000000000000000000000000000012700000032000124000360000000000000610000000000000000041044000800000000000000000000000000005400000000000000076000000000000000000000003000001750000000250000044000000000670000000032000000000360000000000000086919002016085000397000061000000000000000000000500000000000000000000000000000000000000000000000000000000000029000000000000000000000000570000000000000007400000000000000000
SPN565Bacteria;Actinobacteria;Actinomycetia;Actinomycetales;Actinomycetaceae;Actinomyces;israelii_nov_96.324%0000000000000000000000000002430000000000000000000000000000000000047003100000000000000000000121000000000000000000000000000000000000000000000000000000000000000000071000000000000000000000000000000000000000000000000000000000000000000000270000000000000000000000000000000156000000000000000000000000000000000000000000000000000000000000000000207000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021600000000000000000360000000004300050000000000000000850000000000000000000000000000000000000000001160000000000000000000000000000000000000000000000000000000000000000000000000000000000001300000000000000000001090000012
SPN577Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-5];bacterium HMT511 nov_96.593%000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000640000000000000000000000000000000000000000038000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000400000000000000000000000000000000000000000000000000000000000000000000000000027200000000000000000108900000007000000000000000063000000000000000000001120000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000570047
SPN590Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;sp. HMT305 nov_93.898%0000000000000015000023000000000000000000000000000000000000000000000000000000000000016000000720000000000000000000000000000000000000000000000000410000000000000005201300000026000001800000000000010000000000000000000170000000000000000000000430000000000000000000000000000000000000000000001070000000000000000000000000000000001820000000000000000000000000000000000000004300000000000000000000044000000000000000000000000000005700000000000000000000001190000000000000000000000113000000000000002400000000000000000000001600000000000000000004300000000000150000008201800000000003200000000000000000000000000000000000000380000000000000000000005300930000000700380003000000000000000290000000000000000005800000000000000000000000000000011000000
SPN61Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Alloprevotella;rava_nov_97.244%00000000000000000000049000000000000800000000000000000000000000000000000000000003600000000000000000000000000000000000000000000000000000003400000000000000000000000000000000000000000006500000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000560000000133000000000000000000000000000000000000000000000000000000000000000003000000000000000000000000000000001100000000000000000000000000000000000000000000015700000000000000000000000000000000000000075000000000000000000000000000000000000000000000000000000000032000000000000000000000045000000000000000000000000005900000000000000000000000000000000005000000000000000000000000000000000001230000300000000003500000000000000
SPN73Bacteria;Firmicutes;Clostridia;Clostridiales;Veillonellaceae;Selenomonas;sp._Oral_Taxon_G55_nov_97.701%0000000000032000000000270000000000004300000000000000000000000000000000000000000000000000000000000000000000000054000000002500000000000000000000000000000000004600000000000000000000000000000000000000000000000000000000000000000000000013000570000000000036000000000000000000000000000000000007100000000000000000000000000000000000000000000000000005600000000000000000007700000000000000000000000000720000000000910000000000000000000590000000000000000000000033000790000000000000000000000000000000000000000000000000084000000000393500000000000000000000000360000000000000000093000000000000000000000000000000000000000000000000280000000000000000000000000000009000000000000000000000000000000000000000000000006900000000000000
SPN84Bacteria;Proteobacteria;Gammaproteobacteria;Pasteurellales;Pasteurellaceae;Aggregatibacter;segnis_nov_96.402%0000000000000000011700000000000000000000000000000000000000065000000000000000000000000000011400000000000000000000000000000000000000000000000000000000000000003800000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011100000000000000000000000000000000000000000000000000000000000000000000015100000000000000000000000000000000000000000000000000000000000000000008000000000000000000000000000000000000094590000000000000000000000000000000000000000000000000000000000000040000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000066000000000000000000000000000000000000000000000000000
SPN96Bacteria;Bacteroidetes;Bacteroidetes_[C-1];Bacteroidetes_[O-1];Bacteroidetes_[F-1];Bacteroidetes_[G-5];bacterium HMT511 nov_96.593%0000040000000000000000000000000000000000000000000000000000000000000000520000000000000000000000000002300000000000000000000000000000000000570000000000410000000000000000000000000000000000000000000000000000000000000000000000000000000220000000000000001460000000140000000000000000000000000000000000000000066000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149000000000000000000000000000000000000000001050000000000000000000000000000000000000000000000003800000000000000000000000700000000000000000000260000000000000000000000212000000000000000000000000000000000002800000000000000000000000000000000000000000000000000000000000000000000000890000000000000000000000000
SPP1Bacteria;Fusobacteria;Fusobacteriia;Fusobacteriales;Fusobacteriaceae;Fusobacterium;multispecies_spp1_20000000360100010300125000003300000000000219066041692071040015301375740058000000074000004200010200013300001650000000000000008000000000244960000000014804400201210013707300000000000000330000000097000021405100000000022402304210000000000000000239000000019200007430000000000000002300000000089062000000000000002207414000005530044800004490003300001470000003752471000070900000000009900669661280000681013400012100000000001250000001002000459468006710700000000003492590000167029900000022506670021700520000334000000221000006150000000001260000092000093000039600000000011500350000012200028631300000000000000051100022391000000000198162194000000007550001660013609003002010000670000000005200183916700001230000170474000418057000002210013600059200450000000035400202040000000000000000119000000000000134175002110000000000000000000000000007300339001050000000000009820000000076000024800001500173001690000007812441000059705800111000181107
SPP10Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp10_2000000000000000000000000190000000000000000000000000009844000000000000000000000000000000000000000000000042600000000000000000000000000000000097000000000000000000000000290000000000000000000000000000000000000000000001000000000000000000000000000000000000000000790000000000380000000000000000000078380000000000000000000000000081700000000000000000000098000000000000000000000043000000000002800000000005400000000000000000000000000000000000000000000000000000003969000000000030000003800103000000000000000210000000000000000000008300000000000000000000000000043000000000000810000000000280000000000000000000001683000000000000053000000000000000000000000000000000000052200000000000000000000000000410000008900000000030001550000000000000004700
SPP17Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp17_2006300000000000000000000000000000000000000000001097000013001770111000000000000000000000143000028100000000000450000000000000156000008900000000000000000000000000000000000000640008900000000000000000000000000010000000000000000000000344000000000000000000244100000000035000000000000000002430000000000000000000000000000000000000007200000000270000000214000000000000000000000002440000000000000000000000000000000000064851200000000000000000000000000000000020700000027900000000000000000000000000000000000000000000000000000000000726100000008000000000060000000000000000052000000000000000000000000000047000000000006700000000000000000000000000000000000000006800000000000000000000000000460000000000000000000000000000000006400000000000000000000000000000
SPP25Bacteria;Firmicutes;multiclass;multiorder;Veillonellaceae;Mitsuokella;multispecies_spp25_20000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000056000000000000000000000000000000000000000000000001090000000000000000003270000000000000000000000000000000000000000000000000000000000001260000000000000000000000000000000000000001470000000000000000000000000000000000000000000000000000024700000000000000000000000000000000000000000000000000000000000000580000000000000000600000000000000000000033000000000000000000000000000000000000000000000000000000000000000000000000000000046066000000000000000000000000000000000005300000000000000000021000000000000000000000000000000000
SPP26Bacteria;Actinobacteria;Coriobacteriia;Coriobacteriales;multifamily;multigenus;multispecies_spp26_23595110012001486000000000057084000001360000870034020213400159000059000000108032133000038001450000001520000000000532000004200021401490000190031003117101940003042300013118013001020124111023800660002810170000029101290261200000610000002006301044304240001150001020234820000037184001670000000085000204015422800000002852812058000000113850461510001970016963002900003380000006100036500884000004702330316002919200235000000119005543510019610937652000000003137500148000200001590000023600202170011300004104801660024073054019517500000000000270000630000003500000270465002710586877000000031600011900002500009579000100000018000730000036480320013800000022058000000370344000000013300002400049200890041000961040111000022066096148600032218036500014807570227013400014300153070520000000044400430686282066189000570000000000008221450087000100056352004844004622981072126710002620140402001490001200093000003508101000079000015101231130016700011200066360000161940001160006175117000372524700000610004066033101000006100923126012091500000000001410000038
SPP3Bacteria;Firmicutes;Bacilli;Lactobacillales;Carnobacteriaceae;Granulicatella;multispecies_spp3_23700820000000000790891230000000330007905300000006210700001700620720000000006400033006832008274000000000251320000000000018400000131001610014600000000054000000005122000044000261010041000000000001057000000001350040013106400079220600000000000000000500000000000000080000320000590770009700000001522736310000000000046429500184710173002660029018314715004410900009001460000019901841710014601891310000000510000041501690022900174002320000136001770001400000003030332202051021200000003310000014729713806100000175157000000010728153600420000108010283356000276000015100000002030000217001950007100000002712221420076000083000000000000024802740007400417202134400001301530000000000600940000050173702861690129078017700043055222505300018077111154000614462000310059930021300030001580014309802080095001220000830450707100000000000001102011611620428163134500054031906803100780800000000000048971059519011100013516000001821148903100115000010814819217300024872000005206500000007501201137041282000000000450000410620
SPP30Bacteria;Firmicutes;Bacilli;Lactobacillales;Streptococcaceae;Streptococcus;multispecies_spp30_20000000000000000000009900000000000000000000000000000000000000000000000000000000000000000000000025600260000000000000000000000000000000000005900000000000000010700000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364000000000000000000000000000000000000000000000000260000000000000000000000000000000000000000000000003100000000000000000000000000000000000000088000009400000000000000000000000000000000000000000000000000000000000000014200000000000000000000071000000900000000000000000066000000000040000000360000000000000000000000000000000000000000003700000000000000000057000000000000000000000000000000000000000000000000000000000000000004500430000000000000000000042000
SPP44Bacteria;Firmicutes;Clostridia;Clostridiales;Peptostreptococcaceae_[XIII];Peptoniphilus;multispecies_spp44_2000000000000220000000000000000000000000000000000000000004400000000000000000000000000000000000000000005400000000157590000000000001100000000000000000000000000000000000000000044000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000072000000367000000000000000000000011600000000000000000000000000000000008100000000865300000000000000000000000000000000000000000000000000000000147000000025000000000000000000000000000000000000000000000000011000000000000000000000000000000000000000001360000000560000000004100000000000058000000000000000000000000000000000000002400000000000000000000000001600000000000000000000000000000000000003700000000000000000000000000
SPP46Bacteria;Firmicutes;Clostridia;multiorder;Lachnospiraceae_[XIV];Lachnoanaerobaculum;multispecies_spp46_2000000000000000000000013800000000007100000000000000000000000000000000000000000000000099000000000000000000000000000000000006400000000000000000000000000000000001200000000000000000000000000000000000000000000000000000000000000000000000000000059000000000000000000000000000000000000000000000012100000000000000000000000000000000000000000003300000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051000000000000000000000000000000000000000000000000000000000000000000000000000640000000000000000000000000000000000000000000000000000000000000000000000000000000000000
SPP5Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;multispecies_spp5_20000000000009204600007100000000000000000000000000000000046004800001170000000000007300000000000000000000000066000000007700000000000000000000000000000450000000000000000000000001080000000000000000000000000000000000000000106000000000000000000010300000000001000000000000000000000000000000000000197000000000000198000000000000000000002480000000000000000000000000000000000000001370000000000177000000001320900000000000000067002190000000000000000001420000000000000000091000000023200000000000021800000000000000000000003100000000000000000000000001400000000000000000000410000004004300059000000250000000000000000000000007003119000000000078000000000000000034085003000000000003909100010700620000000000028000000000000000000390000000000000000000000000000000000000
SPP57Bacteria;Bacteroidetes;Flavobacteriia;Flavobacteriales;Flavobacteriaceae;Capnocytophaga;multispecies_spp57_200000000000000000000000000015000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005500000320000000000000000000000000000000080000000000000000350000000000720000000000980000033500000000000000000000000000000000000000000000012000184000000000005500000000002180000000000000300000000000000000000000000000000000000000000000000000000000000000000000000000004800000003500000000000000000000340000000000007500000000000000000058000000000000000000000000000000000001100000000690000000000000000000000000000000000004846000000000000000000000000000000000000025000000000000000000410000
SPP59Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;multispecies_spp59_200810000000140000000000000000000000000000000480623700000000000000000000000051000380980000000096000008200002300000000000007200400004600000780000152000000000385046000048000000000000000000000000000620000000084000000000000012400000000000000505000000000000280000000000000352730000690113002500003700003800000000000000000000000000000000000510055000000000000000000000000000000000000003900000007200000000000046005300000012300001480000019900006400000000025691000000000000000004800000000000000000100000082000000000000000056000000008600000054000000000000098000001950000000014000045000000017000011200000000014100000005720000008600000047004800000000000055000000000000010200690000018000450002220013000000000000041000000016550000000000027000000000001350000000310490000000009458000000000000000
SPP6Bacteria;Firmicutes;Clostridia;multiorder;multifamily;Lachnoanaerobaculum;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
SPP60Bacteria;Fusobacteria;Fusobacteria;Fusobacteriales;Fusobacteriaceae;Fusobacterium;multispecies_spp60_22154000334175039403015521800056068002580070118626700000271743650122302991710149002223310002900036102260851212800400114027836523000010050280011400245004540053010001037102130170770506221001070014004113318112056631211001104511352101720067002421470409024660236163005000043321036902630048282000000030637202819414321736401680471950431030013025998171000913641000006800864050102380021600028700014200290005020001390347019707926720581912800083603670007230020800039900000000049446005054221780352659273803180280000000033407870000036329004421920181025998807000000006492420328579058943300001090240000148291828530000000116024200167062000000498003375800187000006080122400608038800002651800010790991327066200348009658800040100002880274397000013700006400104600086606094392360402546983570549015301863060033923412160002131284000003340165010622100119055323859348000730303230320014515855234161118025119810125003933025823316903713961372730469636712714200000913760511101012571372006856301063005504300184061201720035317006009114069005600229001918113041491019104501890392104005386102256000068010604360299010158174012662168203700026809633160675690458027308176275728700125010420104404320041749113600347018402110035000078506529000183803080234850187420000426128386047135507130455312012502850071
SPP62Bacteria;Bacteroidetes;Bacteroidia;Bacteroidales;Prevotellaceae;Prevotella;multispecies_spp62_2000000001140000000000000000000055000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001410000000000000000000000000000000000000000000000000000000000000000000000000000060000000000000000000000000158000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009500000000000000000000023200000000000085000000000000000000000000000000000000000000000000000033000000000000000000490000000000000000000000000000000000000000000000000000000000000000000000000000000
SPPN3Bacteria;Saccharibacteria_(TM7);Saccharibacteria_(TM7)_[C-1];Saccharibacteria_(TM7)_[O-1];Saccharibacteria_(TM7)_[F-1];Saccharibacteria_(TM7)_[G-1];multispecies_sppn3_2_nov_94.839%00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000073000000000000000000000000000000000107000000000000000000000000000000221000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004700000000151000063117000000000000000000000000000000000000054000000000000000000000000000000000000000000000015000000000000000000000000000000000000000032000000000000000000001470000000000000000570047000000000000041000000000000000000000000000000000000
 
 
Download OTU Tables at Different Taxonomy Levels
PhylumCount*: Relative**: CLR***:
ClassCount*: Relative**: CLR***:
OrderCount*: Relative**: CLR***:
FamilyCount*: Relative**: CLR***:
GenusCount*: Relative**: CLR***:
SpeciesCount*: Relative**: CLR***:
* Read count
** Relative abundance (count/total sample count)
*** Centered log ratio transformed abundance
;
 
The species listed in the table has full taxonomy and a dynamically assigned species ID specific to this report. When some reads match with the reference sequences of more than one species equally (i.e., same percent identiy and alignmnet coverage), they can't be assigned to a particular species. Instead, they are assigned to multiple species with the species notaton "s__multispecies_spp2_2". In this notation, spp2 is the dynamic ID assigned to these reads that hit multiple sequences and the "_2" at the end of the notation means there are two species in the spp2.

You can look up which species are included in the multi-species assignment, in this table below:
 
 
 
 
Another type of notation is "s__multispecies_sppn2_2", in which the "n" in the sppn2 means it's a potential novel species because all the reads in this species have < 98% idenity to any of the reference sequences. They were grouped together based on de novo OTU clustering at 98% identity cutoff. And then a representative sequence was chosed to BLASTN search against the reference database to find the closest match (but will still be < 98%). This representative sequence also matched equally to more than one species, hence the "spp" was given in the label.
 
 

Taxonomy Bar Plots for All Samples

 
 

Taxonomy Bar Plots for Individual Comparison Groups

 
 
Comparison No.Comparison NameFamiliesGeneraSpecies
Comparison 1OSS 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 2OSS 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 3Smoker 12 Weeks P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 4Smoker 24 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 5Smoker 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 6Smoker 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 7Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 8Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 9Baseline A P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 10Baseline A P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 11OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 12Baseline A P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 13Baseline A P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 14DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
 
 

VIII. Analysis - Alpha Diversity

 

In ecology, alpha diversity (α-diversity) is the mean species diversity in sites or habitats at a local scale. The term was introduced by R. H. Whittaker[1][2] together with the terms beta diversity (β-diversity) and gamma diversity (γ-diversity). Whittaker's idea was that the total species diversity in a landscape (gamma diversity) is determined by two different things, the mean species diversity in sites or habitats at a more local scale (alpha diversity) and the differentiation among those habitats (beta diversity).


References:
Whittaker, R. H. (1960) Vegetation of the Siskiyou Mountains, Oregon and California. Ecological Monographs, 30, 279–338. doi:10.2307/1943563
Whittaker, R. H. (1972). Evolution and Measurement of Species Diversity. Taxon, 21, 213-251. doi:10.2307/1218190

 

Alpha Diversity Analysis by Rarefaction

Diversity measures are affected by the sampling depth. Rarefaction is a technique to assess species richness from the results of sampling. Rarefaction allows the calculation of species richness for a given number of individual samples, based on the construction of so-called rarefaction curves. This curve is a plot of the number of species as a function of the number of samples. Rarefaction curves generally grow rapidly at first, as the most common species are found, but the curves plateau as only the rarest species remain to be sampled.


References:
Willis AD. Rarefaction, Alpha Diversity, and Statistics. Front Microbiol. 2019 Oct 23;10:2407. doi: 10.3389/fmicb.2019.02407. PMID: 31708888; PMCID: PMC6819366.

 
 
 

Boxplot of Alpha-diversity Indices

The two main factors taken into account when measuring diversity are richness and evenness. Richness is a measure of the number of different kinds of organisms present in a particular area. Evenness compares the similarity of the population size of each of the species present. There are many different ways to measure the richness and evenness. These measurements are called "estimators" or "indices". Below is a diversity of 3 commonly used indices showing the values for all the samples (dots) and in groups (boxes).

 
Alpha Diversity Box Plots for All Groups
 
 
 
 
 
 
 
Alpha Diversity Box Plots for Individual Comparisons
 
Comparison 1OSS 12 Weeks P2 vs DUS 12 Weeks P2View in PDFView in SVG
Comparison 2OSS 24 Weeks P2 vs DUS 24 Weeks P2View in PDFView in SVG
Comparison 3Smoker 12 Weeks P2 vs OSS 12 Weeks P2View in PDFView in SVG
Comparison 4Smoker 24 Weeks P2 vs OSS 24 Weeks P2View in PDFView in SVG
Comparison 5Smoker 12 Weeks P2 vs DUS 12 Weeks P2View in PDFView in SVG
Comparison 6Smoker 24 Weeks P2 vs DUS 24 Weeks P2View in PDFView in SVG
Comparison 7Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2View in PDFView in SVG
Comparison 8Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2View in PDFView in SVG
Comparison 9Baseline A P2 vs OSS 12 Weeks P2View in PDFView in SVG
Comparison 10Baseline A P2 vs OSS 24 Weeks P2View in PDFView in SVG
Comparison 11OSS 12 Weeks P2 vs OSS 24 Weeks P2View in PDFView in SVG
Comparison 12Baseline A P2 vs DUS 12 Weeks P2View in PDFView in SVG
Comparison 13Baseline A P2 vs DUS 24 Weeks P2View in PDFView in SVG
Comparison 14DUS 12 Weeks P2 vs DUS 24 Weeks P2View in PDFView in SVG
 
 
 

Group Significance of Alpha-diversity Indices

To test whether the alpha diversity among different comparison groups are different statisticall, we use the Kruskal Wallis H test provided the "alpha-group-significance" fucntion in the QIIME 2 diversity package. Kruskal Wallis H test is the non parametric alternative to the One Way ANOVA. Non parametric means that the test doesn’t assume your data comes from a particular distribution. The H test is used when the assumptions for ANOVA aren’t met (like the assumption of normality). It is sometimes called the one-way ANOVA on ranks, as the ranks of the data values are used in the test rather than the actual data points. The test determines whether the medians of two or more groups are different.

Below are the Kruskal Wallis H test results for each comparison based on three different alpha diversity measures: 1) Observed species (features), 2) Shannon index, and 3) Simpson index.

 
 
Comparison 1.OSS 12 Weeks P2 vs DUS 12 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 2.OSS 24 Weeks P2 vs DUS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 3.Smoker 12 Weeks P2 vs OSS 12 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 4.Smoker 24 Weeks P2 vs OSS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 5.Smoker 12 Weeks P2 vs DUS 12 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 6.Smoker 24 Weeks P2 vs DUS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 7.Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 8.Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 9.Baseline A P2 vs OSS 12 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 10.Baseline A P2 vs OSS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 11.OSS 12 Weeks P2 vs OSS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 12.Baseline A P2 vs DUS 12 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 13.Baseline A P2 vs DUS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
Comparison 14.DUS 12 Weeks P2 vs DUS 24 Weeks P2Observed FeaturesShannon IndexSimpson Index
 
 

IX. Analysis - Beta Diversity

 

NMDS and PCoA Plots

Beta diversity compares the similarity (or dissimilarity) of microbial profiles between different groups of samples. There are many different similarity/dissimilarity metrics. In general, they can be quantitative (using sequence abundance, e.g., Bray-Curtis or weighted UniFrac) or binary (considering only presence-absence of sequences, e.g., binary Jaccard or unweighted UniFrac). They can be even based on phylogeny (e.g., UniFrac metrics) or not (non-UniFrac metrics, such as Bray-Curtis, etc.).

For microbiome studies, species profiles of samples can be compared with the Bray-Curtis dissimilarity, which is based on the count data type. The pair-wise Bray-Curtis dissimilarity matrix of all samples can then be subject to either multi-dimensional scaling (MDS, also known as PCoA) or non-metric MDS (NMDS).

MDS/PCoA is a scaling or ordination method that starts with a matrix of similarities or dissimilarities between a set of samples and aims to produce a low-dimensional graphical plot of the data in such a way that distances between points in the plot are close to original dissimilarities.

NMDS is similar to MDS, however it does not use the dissimilarities data, instead it converts them into the ranks and use these ranks in the calculation.

In our beta diversity analysis, Bray-Curtis dissimilarity matrix was first calculated and then plotted by the PCoA and NMDS separately. Below are beta diveristy results for all groups together:

 
 
NMDS and PCoA Plots for All Groups
 
 
 
 
 

The above PCoA and NMDS plots are based on count data. The count data can also be transformed into centered log ratio (CLR) for each species. The CLR data is no longer count data and cannot be used in Bray-Curtis dissimilarity calculation. Instead CLR can be compared with Euclidean distances. When CLR data are compared by Euclidean distance, the distance is also called Aitchison distance.

Below are the NMDS and PCoA plots of the Aitchison distances of the samples:

 
 
 
 
 
 
 
NMDS and PCoA Plots for Individual Comparisons
 
 
Comparison No.Comparison NameNMDAPCoA
Bray-CurtisCLR EuclideanBray-CurtisCLR Euclidean
Comparison 1OSS 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 2OSS 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 3Smoker 12 Weeks P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 4Smoker 24 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 5Smoker 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 6Smoker 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 7Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 8Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 9Baseline A P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 10Baseline A P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 11OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 12Baseline A P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 13Baseline A P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
Comparison 14DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVGPDFSVG
 
 
 
 
 

Interactive 3D PCoA Plots - Bray-Curtis Dissimilarity

 
 
 

Interactive 3D PCoA Plots - Euclidean Distance

 
 
 

Interactive 3D PCoA Plots - Correlation Coefficients

 
 
 

Group Significance of Beta-diversity Indices

To test whether the between-group dissimilarities are significantly greater than the within-group dissimilarities, the "beta-group-significance" function provided in the QIIME 2 "diversity" package was used with PERMANOVA (permutational multivariate analysis of variance) chosen s the group significan testing method.

Three beta diversity matrics were used: 1) Bray–Curtis dissimilarity 2) Correlation coefficient matrix , and 3) Aitchison distance (Euclidean distance between clr-transformed compositions).

 
 
Comparison 1.OSS 12 Weeks P2 vs DUS 12 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 2.OSS 24 Weeks P2 vs DUS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 3.Smoker 12 Weeks P2 vs OSS 12 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 4.Smoker 24 Weeks P2 vs OSS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 5.Smoker 12 Weeks P2 vs DUS 12 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 6.Smoker 24 Weeks P2 vs DUS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 7.Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 8.Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 9.Baseline A P2 vs OSS 12 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 10.Baseline A P2 vs OSS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 11.OSS 12 Weeks P2 vs OSS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 12.Baseline A P2 vs DUS 12 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 13.Baseline A P2 vs DUS 24 Weeks P2Bray–CurtisCorrelationAitchison
Comparison 14.DUS 12 Weeks P2 vs DUS 24 Weeks P2Bray–CurtisCorrelationAitchison
 
 
 

X. Analysis - Differential Abundance

16S rRNA next generation sequencing (NGS) generates a fixed number of reads that reflect the proportion of different species in a sample, i.e., the relative abundance of species, instead of the absolute abundance. In Mathematics, measurements involving probabilities, proportions, percentages, and ppm can all be thought of as compositional data. This makes the microbiome read count data “compositional” (Gloor et al, 2017). In general, compositional data represent parts of a whole which only carry relative information (http://www.compositionaldata.com/).

The problem of microbiome data being compositional arises when comparing two groups of samples for identifying “differentially abundant” species. A species with the same absolute abundance between two conditions, its relative abundances in the two conditions (e.g., percent abundance) can become different if the relative abundance of other species change greatly. This problem can lead to incorrect conclusion in terms of differential abundance for microbial species in the samples.

When studying differential abundance (DA), the current better approach is to transform the read count data into log ratio data. The ratios are calculated between read counts of all species in a sample to a “reference” count (e.g., mean read count of the sample). The log ratio data allow the detection of DA species without being affected by percentage bias mentioned above

In this report, a compositional DA analysis tool “ANCOM” (analysis of composition of microbiomes) was used. ANCOM transforms the count data into log-ratios and thus is more suitable for comparing the composition of microbiomes in two or more populations. "ANCOM" generates a table of features with W-statistics and whether the null hypothesis is rejected. The “W” is the W-statistic, or number of features that a single feature is tested to be significantly different against. Hence the higher the "W" the more statistical sifgnificane that a feature/species is differentially abundant.


References:

Gloor GB, Macklaim JM, Pawlowsky-Glahn V, Egozcue JJ. Microbiome Datasets Are Compositional: And This Is Not Optional. Front Microbiol. 2017 Nov 15;8:2224. doi: 10.3389/fmicb.2017.02224. PMID: 29187837; PMCID: PMC5695134.

Mandal S, Van Treuren W, White RA, Eggesbø M, Knight R, Peddada SD. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb Ecol Health Dis. 2015 May 29;26:27663. doi: 10.3402/mehd.v26.27663. PMID: 26028277; PMCID: PMC4450248.

Lin H, Peddada SD. Analysis of compositions of microbiomes with bias correction. Nat Commun. 2020 Jul 14;11(1):3514. doi: 10.1038/s41467-020-17041-7. PMID: 32665548; PMCID: PMC7360769.

 
 

ANCOM Differential Abundance Analysis

 
ANCOM Results for Individual Comparisons
Comparison No.Comparison Name
Comparison 1.OSS 12 Weeks P2 vs DUS 12 Weeks P2
Comparison 2.OSS 24 Weeks P2 vs DUS 24 Weeks P2
Comparison 3.Smoker 12 Weeks P2 vs OSS 12 Weeks P2
Comparison 4.Smoker 24 Weeks P2 vs OSS 24 Weeks P2
Comparison 5.Smoker 12 Weeks P2 vs DUS 12 Weeks P2
Comparison 6.Smoker 24 Weeks P2 vs DUS 24 Weeks P2
Comparison 7.Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2
Comparison 8.Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2
Comparison 9.Baseline A P2 vs OSS 12 Weeks P2
Comparison 10.Baseline A P2 vs OSS 24 Weeks P2
Comparison 11.OSS 12 Weeks P2 vs OSS 24 Weeks P2
Comparison 12.Baseline A P2 vs DUS 12 Weeks P2
Comparison 13.Baseline A P2 vs DUS 24 Weeks P2
Comparison 14.DUS 12 Weeks P2 vs DUS 24 Weeks P2
 
 

ANCOM-BC Differential Abundance Analysis

 

Starting with version V1.2, we also include the results of ANCOM-BC (Analysis of Compositions of Microbiomes with Bias Correction) (Lin and Peddada 2020). ANCOM-BC is an updated version of "ANCOM" that: (a) provides statistically valid test with appropriate p-values, (b) provides confidence intervals for differential abundance of each taxon, (c) controls the False Discovery Rate (FDR), (d) maintains adequate power, and (e) is computationally simple to implement. The bias correction (BC) addresses a challenging problem of the bias introduced by differences in the sampling fractions across samples. This bias has been a major hurdle in performing DA analysis of microbiome data. ANCOM-BC estimates the unknown sampling fractions and corrects the bias induced by their differences among samples. The absolute abundance data are modeled using a linear regression framework.

References:

Lin H, Peddada SD. Analysis of compositions of microbiomes with bias correction. Nat Commun. 2020 Jul 14;11(1):3514. doi: 10.1038/s41467-020-17041-7. PMID: 32665548; PMCID: PMC7360769.

 
 
ANCOM-BC Results for Individual Comparisons
 
Comparison No.Comparison Name
Comparison 1.OSS 12 Weeks P2 vs DUS 12 Weeks P2
Comparison 2.OSS 24 Weeks P2 vs DUS 24 Weeks P2
Comparison 3.Smoker 12 Weeks P2 vs OSS 12 Weeks P2
Comparison 4.Smoker 24 Weeks P2 vs OSS 24 Weeks P2
Comparison 5.Smoker 12 Weeks P2 vs DUS 12 Weeks P2
Comparison 6.Smoker 24 Weeks P2 vs DUS 24 Weeks P2
Comparison 7.Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2
Comparison 8.Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2
Comparison 9.Baseline A P2 vs OSS 12 Weeks P2
Comparison 10.Baseline A P2 vs OSS 24 Weeks P2
Comparison 11.OSS 12 Weeks P2 vs OSS 24 Weeks P2
Comparison 12.Baseline A P2 vs DUS 12 Weeks P2
Comparison 13.Baseline A P2 vs DUS 24 Weeks P2
Comparison 14.DUS 12 Weeks P2 vs DUS 24 Weeks P2
 
 
 

LEfSe - Linear Discriminant Analysis Effect Size

LEfSe (Linear Discriminant Analysis Effect Size) is an alternative method to find "organisms, genes, or pathways that consistently explain the differences between two or more microbial communities" (Segata et al., 2011). Specifically, LEfSe uses rank-based Kruskal-Wallis (KW) sum-rank test to detect features with significant differential (relative) abundance with respect to the class of interest. Since it is rank-based, instead of proportional based, the differential species identified among the comparison groups is less biased (than percent abundance based).

Reference:

Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C. Metagenomic biomarker discovery and explanation. Genome Biol. 2011 Jun 24;12(6):R60. doi: 10.1186/gb-2011-12-6-r60. PMID: 21702898; PMCID: PMC3218848.

 
OSS 12 Weeks P2 vs DUS 12 Weeks P2
 
 
 
 
 
 
 
LEfSe Results for All Comparisons
 
Comparison No.Comparison Name
Comparison 1.OSS 12 Weeks P2 vs DUS 12 Weeks P2
Comparison 2.OSS 24 Weeks P2 vs DUS 24 Weeks P2
Comparison 3.Smoker 12 Weeks P2 vs OSS 12 Weeks P2
Comparison 4.Smoker 24 Weeks P2 vs OSS 24 Weeks P2
Comparison 5.Smoker 12 Weeks P2 vs DUS 12 Weeks P2
Comparison 6.Smoker 24 Weeks P2 vs DUS 24 Weeks P2
Comparison 7.Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2
Comparison 8.Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2
Comparison 9.Baseline A P2 vs OSS 12 Weeks P2
Comparison 10.Baseline A P2 vs OSS 24 Weeks P2
Comparison 11.OSS 12 Weeks P2 vs OSS 24 Weeks P2
Comparison 12.Baseline A P2 vs DUS 12 Weeks P2
Comparison 13.Baseline A P2 vs DUS 24 Weeks P2
Comparison 14.DUS 12 Weeks P2 vs DUS 24 Weeks P2
 
 

XI. Analysis - Heatmap Profile

 

Species vs Sample Abundance Heatmap for All Samples

 
 
 

Heatmaps for Individual Comparisons

 
A) Two-way clustering - clustered on both columns (Samples) and rows (organism)
Comparison No.Comparison NameFamily LevelGenus LevelSpecies Level
Comparison 1OSS 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 2OSS 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 3Smoker 12 Weeks P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 4Smoker 24 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 5Smoker 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 6Smoker 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 7Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 8Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 9Baseline A P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 10Baseline A P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 11OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 12Baseline A P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 13Baseline A P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 14DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
 
 
B) One-way clustering - clustered on rows (organism) only
Comparison No.Comparison NameFamily LevelGenus LevelSpecies Level
Comparison 1OSS 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 2OSS 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 3Smoker 12 Weeks P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 4Smoker 24 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 5Smoker 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 6Smoker 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 7Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 8Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 9Baseline A P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 10Baseline A P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 11OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 12Baseline A P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 13Baseline A P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 14DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
 
 
C) No clustering
Comparison No.Comparison NameFamily LevelGenus LevelSpecies Level
Comparison 1OSS 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 2OSS 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 3Smoker 12 Weeks P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 4Smoker 24 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 5Smoker 12 Weeks P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 6Smoker 24 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 7Baseline A P2 vs OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 8Baseline A P2 vs DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 9Baseline A P2 vs OSS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 10Baseline A P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 11OSS 12 Weeks P2 vs OSS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 12Baseline A P2 vs DUS 12 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 13Baseline A P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
Comparison 14DUS 12 Weeks P2 vs DUS 24 Weeks P2PDFSVGPDFSVGPDFSVG
 
 

XII. Analysis - Network Association

To analyze the co-occurrence or co-exclusion between microbial species among different samples, network correlation analysis tools are usually used for this purpose. However, microbiome count data are compositional. If count data are normalized to the total number of counts in the sample, the data become not independent and traditional statistical metrics (e.g., correlation) for the detection of specie-species relationships can lead to spurious results. In addition, sequencing-based studies typically measure hundreds of OTUs (species) on few samples; thus, inference of OTU-OTU association networks is severely under-powered. Here we use SPIEC-EASI (SParse InversE Covariance Estimation for Ecological Association Inference), a statistical method for the inference of microbial ecological networks from amplicon sequencing datasets that addresses both of these issues (Kurtz et al., 2015). SPIEC-EASI combines data transformations developed for compositional data analysis with a graphical model inference framework that assumes the underlying ecological association network is sparse. SPIEC-EASI provides two algorithms for network inferencing – 1) Meinshausen-Bühlmann's neighborhood selection (MB method) and inverse covariance selection (GLASSO method, i.e., graphical least absolute shrinkage and selection operator). This is fundamentally distinct from SparCC, which essentially estimate pairwise correlations. In addition to these two methods, we provide the results of a third method - SparCC (Sparse Correlations for Compositional Data)(Friedman & Alm 2012), which is also a method for inferring correlations from compositional data. SparCC estimates the linear Pearson correlations between the log-transformed components.


References:

Kurtz ZD, Müller CL, Miraldi ER, Littman DR, Blaser MJ, Bonneau RA. Sparse and compositionally robust inference of microbial ecological networks. PLoS Comput Biol. 2015 May 7;11(5):e1004226. doi: 10.1371/journal.pcbi.1004226. PMID: 25950956; PMCID: PMC4423992.

Friedman J, Alm EJ. Inferring correlation networks from genomic survey data. PLoS Comput Biol. 2012;8(9):e1002687. doi: 10.1371/journal.pcbi.1002687. Epub 2012 Sep 20. PMID: 23028285; PMCID: PMC3447976.

 

SPIEC-EASI Network Inference by Neighborhood Selection (MB Method)

 
 

 

Association Network Inference by SparCC

 
 

 
 
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